ID   A0A087XP82_POEFO        Unreviewed;       247 AA.
AC   A0A087XP82;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   06-JUL-2016, entry version 9.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000007585};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000007585, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000007585, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000007585}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000007585}.
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DR   EMBL; AYCK01016989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007575755.1; XM_007575693.2.
DR   Ensembl; ENSPFOT00000007597; ENSPFOP00000007585; ENSPFOG00000007628.
DR   GeneID; 103154418; -.
DR   GeneTree; ENSGT00510000048687; -.
DR   OMA; GWYISTA; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   247 AA;  27793 MW;  0070AAD1FF794E26 CRC64;
     MESKKNCSIS QMWANKMPKG VDLEISHQPP SMRCVANLII AMERLKSGMA ESILSPGFSD
     ESLLSIMLES VVEERFISER TSAQPGQFTR REEHHCSVTD GQKRSLVLVK NNMELLAVML
     QGGRGSLKVY LNMATYIHLT PDTGLGQPVV LGIRDTDFYL SCHKDGDKPT LHLEVVEDKM
     SLSEISAESD LRRFLFYKRD TGLNVSTLMS ANFPNWYIST ATDNSRPVAM CQESASRYRT
     FSIQRQS
//
ID   A0A087YDX3_POEFO        Unreviewed;       218 AA.
AC   A0A087YDX3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   11-MAY-2016, entry version 8.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000016226};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000016226, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000016226, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000016226}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000016226}.
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DR   EMBL; AYCK01019873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000016248; ENSPFOP00000016226; ENSPFOG00000016167.
DR   GeneTree; ENSGT00520000060257; -.
DR   OMA; MATCEDS; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   218 AA;  25525 MW;  C56E91ED2CB9625B CRC64;
     METYCGLSFM FLFCRHPLMA TCEDSHLKFI QTINNSFYFE ETSSAPCETE LCSDAFRRRE
     PPISMWIQSK DQKFLVLKTS GKFEFEDRTV HDRGQPDCQF EIQIYQDSLS NKYQSVMLYV
     CADGEKMMIS CKDYKEVCPE PMDPKVLKMI KAAEHKALFR WKCISTGKYK FESTMYPGFF
     LAFEHVEDMP CLHKLILRHG SMDEVDESGI FYVNKCSP
//
ID   A0A087YFV0_POEFO        Unreviewed;       352 AA.
AC   A0A087YFV0;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   06-JUL-2016, entry version 9.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000016903};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000016903, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000016903, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000016903}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000016903}.
CC   -----------------------------------------------------------------------
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CC   -----------------------------------------------------------------------
DR   EMBL; AYCK01008182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007560209.1; XM_007560147.2.
DR   Ensembl; ENSPFOT00000016925; ENSPFOP00000016903; ENSPFOG00000016840.
DR   GeneID; 103143562; -.
DR   GeneTree; ENSGT00390000016316; -.
DR   OMA; ITIYYYK; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR001478; PDZ.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   352 AA;  40249 MW;  9D9065DD730DE7F9 CRC64;
     MDMDDSTVKG SVLIRHQLHE GKHLYEVEEV VKYKSKTGKK MFIRRGDKLM EINGVDLQDL
     EPEELANMIS EGNPLLSVQK REKESEQEEQ LPLDEDTLQP YDKESTVLSF SWELKREEDT
     EEGEKNEPTD IEGNVCEDMC KENGESRDLL VIHMTNTSIA VVGSRGCEEF EGTGCTVDDI
     VLVADSSVVT CVSRGDVNFR QEKLADVLIK HVPTHRYLRT ICSEKTVYSS PNPEKITIYY
     YKSNAMDKTF RGIAVVLNLT GSNCFLKCCK EGDRVLLQVE TCEKQRLRQI SKNDDCTFSF
     VFYMLADRTK QRKFESALHR GWFIHIANTD LVEMAETDGE MGDSSFLFII QK
//
ID   A0A087YLM6_POEFO        Unreviewed;       267 AA.
AC   A0A087YLM6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   06-JUL-2016, entry version 8.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPFOP00000018929};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000018929, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000018929, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000018929}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000018929}.
CC   -----------------------------------------------------------------------
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CC   -----------------------------------------------------------------------
DR   EMBL; AYCK01014439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016537210.1; XM_016681724.1.
DR   Ensembl; ENSPFOT00000018951; ENSPFOP00000018929; ENSPFOG00000018826.
DR   GeneID; 103151753; -.
DR   GeneTree; ENSGT00510000048687; -.
DR   OMA; ESVKFRG; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   267 AA;  29914 MW;  8BA51304B9C1CBEA CRC64;
     MSDFDLIDAL DCSPEIRHPP SRTEQDVERE VKLSEDLNLM VTCNTITMKS VANLVLAVNK
     LSKSLSLCSR DLSDEELCGA IMDCVVEETI FQEGWSNSSG TRKSVFQRCR SVHKFTVSDE
     YQKDFILKTG EMKLQAITLQ GGNGDRKVNF EMCHYRPPSS SSICSLTVLL SVSENLHISC
     SMENGKVSLK LEQYSHESLT EINQEDGLDR FLFIKNIPPG GSLVSFESVK FRGWFISTSS
     SSVDYSVEMC QAATASRVTY FVFQKCN
//
ID   A0A091CSB5_FUKDA        Unreviewed;       294 AA.
AC   A0A091CSB5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 9.
DE   SubName: Full=Interleukin-18 {ECO:0000313|EMBL:KFO20743.1};
GN   ORFNames=H920_17906 {ECO:0000313|EMBL:KFO20743.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO20743.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO20743.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO20743.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KN124601; KFO20743.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   294 AA;  33696 MW;  2A875992CC2B4BA7 CRC64;
     MVRNFVLKYD QKASNRDSGE KRRFYGTKPL HFLQVCASCT SEREKTAKQP RDLFSQAVSI
     LVCPRRWLQE QLPPFVISIA SGTGNRPHTF QIASSCRKTI CTGMMMAVSV SEKDCINFVE
     MKFIDNILYF IQNLESDYFG KLVPKLSIIR NLKNQVLIVN CEKQPVFEDM PDSDIAGNAP
     RTTFNKYTYT DSCGRGMAVV ISVMCNGKHT LSCEDKTISF KEINPPDNIN DTKSDIIFFQ
     RCVPGHDDKM QFESSLYEGY FLACQKEKDF YKLILKKKDE FGDTSIMFTV QNKD
//
ID   A0A091D3Q7_FUKDA        Unreviewed;       158 AA.
AC   A0A091D3Q7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 9.
DE   SubName: Full=Interleukin-1 family member 10 {ECO:0000313|EMBL:KFO26699.1};
GN   ORFNames=H920_11897 {ECO:0000313|EMBL:KFO26699.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26699.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO26699.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO26699.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KN123107; KFO26699.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   158 AA;  17693 MW;  D6ED207425DB0E7D CRC64;
     MRKIDNCAVK AKTTRSRIRD ADQKILYIRD DQLLVGDPDA DSCNAEKICI LPNRGLDRTK
     VPIFLGIQGG SRCLGCVETR EGPSLKLEDV NIEDLYKGGE QATRFTFFQS SLGSAFRLEA
     AACPGWFLCG PDEPQQPIRL SKESEPSART QFYFEQSR
//
ID   A0A091D3R2_FUKDA        Unreviewed;       266 AA.
AC   A0A091D3R2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 10.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:KFO26704.1};
GN   ORFNames=H920_11902 {ECO:0000313|EMBL:KFO26704.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26704.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO26704.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO26704.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KN123107; KFO26704.1; -; Genomic_DNA.
DR   RefSeq; XP_010637795.1; XM_010639493.1.
DR   GeneID; 104873032; -.
DR   CTD; 3553; -.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    101       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   266 AA;  31000 MW;  F5BFC1FF743BAD1C CRC64;
     MAAVPEFSDE VTAYHSDENE MFFEIDGPKQ QYCFQDLDLC SLDEGIELQI SHQHFNKSFR
     QVVSLIVAVK KLRKELVPCP WTFQDNDLKT FFPFIFEEEP IIYDTWDDKY ECDAPVLTRN
     CRLHDAQHKH FVLSDPCELK ALHLNGDNLN RQVVFSMSFV QGERRDDKIP VALGLKGKNL
     YLSCVMKDDK PVLQLESVDP KQYPKKKMEK RFIFNKIESK STVEFESAQF PNWYISTSQT
     EHMPVFLGNN HGGQDITDFH LEFVSS
//
ID   A0A091D6P4_FUKDA        Unreviewed;       152 AA.
AC   A0A091D6P4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 10.
DE   SubName: Full=Interleukin-36 alpha {ECO:0000313|EMBL:KFO26702.1};
GN   ORFNames=H920_11900 {ECO:0000313|EMBL:KFO26702.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26702.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO26702.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO26702.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KN123107; KFO26702.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  17206 MW;  532D8753D5ABB096 CRC64;
     MKIPFERHIQ DLDQRVWVLL GQTLTMVPRK GNVVPVTVDL YPCKYLETLE KGRGNPMYLG
     LKELQCSLFC TKIGEETTLQ LNKKNVKELY DGPQPEKPFL FYHNEVGSTS TFESAAFPGW
     FIATGSKGES PVFMTQEVGK THVTEFVLTT LS
//
ID   A0A091D8D3_FUKDA        Unreviewed;       162 AA.
AC   A0A091D8D3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 10.
DE   SubName: Full=Interleukin-1 receptor antagonist protein {ECO:0000313|EMBL:KFO26698.1};
GN   ORFNames=H920_11896 {ECO:0000313|EMBL:KFO26698.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26698.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO26698.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO26698.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
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DR   EMBL; KN123107; KFO26698.1; -; Genomic_DNA.
DR   RefSeq; XP_010637790.1; XM_010639488.1.
DR   GeneID; 104873028; -.
DR   CTD; 3557; -.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Receptor {ECO:0000313|EMBL:KFO26698.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   162 AA;  18591 MW;  07001B2164A39532 CRC64;
     MAAARLEAAC RPFGRRPYKM QSFRIWDINQ KTFYLRNNQL VAGYLQVPNT KLEEKIDMVP
     IDPHTVFLGI HKGKLCLSCV KSGDDISLQL ETVNITELSK NKEQNKRFTF IRSNSGPITS
     FQSAACPGWF LCTVVEADQP VRFTNNLEDS DMVTKFYFQE DQ
//
ID   A0A091D8D8_FUKDA        Unreviewed;       183 AA.
AC   A0A091D8D8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 9.
DE   SubName: Full=Interleukin-37 {ECO:0000313|EMBL:KFO26703.1};
GN   ORFNames=H920_11901 {ECO:0000313|EMBL:KFO26703.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26703.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO26703.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO26703.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KN123107; KFO26703.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   183 AA;  20323 MW;  AC22092065ED4F87 CRC64;
     MEIDSKDWEK DEYQCCSEGS KVKVKDPQKF SIRDGDQNVV VLDCGNLLAV PKKSYILSET
     FFALPSHLKS ATAGKGDPIL LAVSKGELCL CCDKDKGKSH PSLLLKKKKL MKLADEKEAV
     RKPFIFYNAK VGSLHTLESA AHRGWFICTS CNSGEPIGVT DKVGQKKHIE FLFEKVCKPE
     MSP
//
ID   A0A091D910_FUKDA        Unreviewed;       176 AA.
AC   A0A091D910;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 9.
DE   SubName: Full=Interleukin-36 receptor antagonist protein {ECO:0000313|EMBL:KFO26700.1};
GN   ORFNames=H920_11898 {ECO:0000313|EMBL:KFO26700.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26700.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO26700.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO26700.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KN123107; KFO26700.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Receptor {ECO:0000313|EMBL:KFO26700.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   176 AA;  19604 MW;  6D871B94D75578FE CRC64;
     MTRQYGSAAM VAEYWAPTHN PVSLLAEKME RLVGIEKVKP QTPEVNGDCE LIPLEGHKPG
     EEISVVPNRW LDARLSPVIL GVQGGSQCLS CGTGEEPTLK LEPVNIMELY LGTQESKRFT
     FYRQDLGLTS SFESAAYPGW FLCTAPEADQ PVRLSQISEN SPWDTSITDF YFQQCD
//
ID   A0A091D913_FUKDA        Unreviewed;       270 AA.
AC   A0A091D913;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 10.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|EMBL:KFO26705.1};
GN   ORFNames=H920_11903 {ECO:0000313|EMBL:KFO26705.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26705.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO26705.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO26705.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KN123107; KFO26705.1; -; Genomic_DNA.
DR   RefSeq; XP_010637796.1; XM_010639494.1.
DR   GeneID; 104873033; -.
DR   CTD; 3552; -.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    111       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   270 AA;  30616 MW;  654FD358A6821C8C CRC64;
     MAEVPNLFED LKSCYSENEE YASAIDRFSL NQKSFYDTSY GPLDENCMNK SVSLSTLQTS
     EVSELSFKEN LVVVSTSAHR KVLKKRRLSL NQTITNEDLE AIINGPEEEI IKPRSAPHIF
     QSNVKYKYMR ILRKEFVLND SIHQSVTLDA TGQYLKAVAL TDLSHEVKFD MGGYISATDD
     NTNPVTLRIS KTRLFVSAQE EDQPVLLKEM PETPKIITGN ELNLLFLWEN ERGHNFFRSA
     ANSELLIATK EDSLVHMARG SSSMTDFQIS
//
ID   A0A091DVA7_FUKDA        Unreviewed;       150 AA.
AC   A0A091DVA7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 9.
DE   SubName: Full=Interleukin-36 beta {ECO:0000313|EMBL:KFO26701.1};
DE   Flags: Fragment;
GN   ORFNames=H920_11899 {ECO:0000313|EMBL:KFO26701.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26701.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO26701.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO26701.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
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DR   EMBL; KN123107; KFO26701.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFO26701.1}.
SQ   SEQUENCE   150 AA;  16882 MW;  CE40F90C309B5A3E CRC64;
     EIPRYYHIHD SEQMVWLLSG NVLVAAPSSN NIEPITLAII ACRDTKLFDE GKGNLVYLGI
     KDKNLSLFCT ETEGKPTLQL KEINIMDLYR ETISQQPFLF FHSVEGSISS FQPFSYPGWF
     IATSSVPSQP VFLTEGRGST NTNFYLAPKI
//
ID   A0A093BLL4_CHAPE        Unreviewed;       163 AA.
AC   A0A093BLL4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 8.
DE   SubName: Full=Interleukin-18 {ECO:0000313|EMBL:KFU89418.1};
DE   Flags: Fragment;
GN   ORFNames=M959_13929 {ECO:0000313|EMBL:KFU89418.1};
OS   Chaetura pelagica (Chimney swift).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Apodiformes; Apodidae; Chaetura.
OX   NCBI_TaxID=8897 {ECO:0000313|EMBL:KFU89418.1, ECO:0000313|Proteomes:UP000031515};
RN   [1] {ECO:0000313|EMBL:KFU89418.1, ECO:0000313|Proteomes:UP000031515}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M959 {ECO:0000313|EMBL:KFU89418.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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DR   EMBL; KN126419; KFU89418.1; -; Genomic_DNA.
DR   Proteomes; UP000031515; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031515};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031515};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFU89418.1}.
FT   NON_TER     163    163       {ECO:0000313|EMBL:KFU89418.1}.
SQ   SEQUENCE   163 AA;  18703 MW;  2C66CDE6E2C8DD27 CRC64;
     ELECDAFRRE KILQRVLRNV NSQLLVVRPD LNVAAFEDVT DQEMKSGNGM HFSIHCYKTT
     TPSAGLPVAF SVLVEDKSYY MCCEEERGRI TVRFKEGKVP AEFPGESNII FFKTTFTPES
     SRAFKFEYSL KQGMFLAFQQ EDGLRKLILK KVSRGEVDET VKI
//
ID   A0A096MQL1_PAPAN        Unreviewed;       193 AA.
AC   A0A096MQL1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000002044};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSPANP00000002044};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000002044, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000002044}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000002044}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ01092150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003910750.1; XM_003910701.2.
DR   RefSeq; XP_009185537.1; XM_009187273.1.
DR   Ensembl; ENSPANT00000002428; ENSPANP00000002044; ENSPANG00000012221.
DR   GeneID; 101011371; -.
DR   CTD; 3606; -.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; PVFEDMP; -.
DR   Proteomes; UP000028761; Chromosome 14.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22380 MW;  55AB4727A121F853 CRC64;
     MAAEPAEDNC INFVAMKFID STLYFIAEDD ENLESDYFRK LESKLSIIRN LNDQVLFIDQ
     GNRPLFEDMT DSDCRDNAPR TIFIINMYKD SQPRGMAVAI SVKCEKISTL SCENRIVSFK
     EMNPPDNIKD AKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLY KLILKKKDEL
     GDRSIMFTVQ NED
//
ID   A0A096NEW1_PAPAN        Unreviewed;       268 AA.
AC   A0A096NEW1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 12.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000011447};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSPANP00000011447};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011447, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000011447}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000011447}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ01196753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003909194.1; XM_003909145.2.
DR   Ensembl; ENSPANT00000025021; ENSPANP00000011447; ENSPANG00000000795.
DR   GeneID; 101023446; -.
DR   CTD; 3553; -.
DR   GeneTree; ENSGT00510000048687; -.
DR   OMA; SNDKIPV; -.
DR   Proteomes; UP000028761; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30386 MW;  4B46BE56BFA67D71 CRC64;
     MAEVPELASE MMAYYSGNED DLFFEVDGPK QMKCSFQDLD LCPLDGGIQL QISHEHYNRG
     FRQAVSVVVA MEKLRKMLVP CPQTFQDNDL STLIPFIFEE EPVFLDTCNN DACVHDAPVR
     SLHCTLRDAQ LKSLVMSGPY ELKALHLQGQ DLEQQVVFSM SFVQGEESND KVPVALGLKA
     KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST
     SQAENMPVFL GGTRGGQDIT DFTMQFAS
//
ID   A0A096NEW2_PAPAN        Unreviewed;       200 AA.
AC   A0A096NEW2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 10.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000011448};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSPANP00000011448};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011448, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000011448}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000011448}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ01196750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000013268; ENSPANP00000011448; ENSPANG00000007702.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; RKHTEFS; -.
DR   Proteomes; UP000028761; Chromosome 13.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   200 AA;  21909 MW;  E83DB4B266A6887D CRC64;
     MLTSLCLTAD LAGSPLEPGP SLPSMNFVHT SPKVKNLNPK KFSIHDQDHK VLVVDSGNLI
     AVPDKNYIRP EIFFALASSL SSASAEKGSP ILLGVSKGEF CLSCDKDKGQ SHPSLQLKKK
     KLMKLAALKE SARRPFIFYR AQVGSRNMLE SAAHPGWFIC TSCNCNEPVG VTDKFENRKH
     IEFSFQPVCK AEMSPSEVSD
//
ID   A0A096NEW3_PAPAN        Unreviewed;       168 AA.
AC   A0A096NEW3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000011449};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSPANP00000011449};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011449, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000011449}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000011449}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ01196747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003909198.1; XM_003909149.2.
DR   Ensembl; ENSPANT00000011673; ENSPANP00000011449; ENSPANG00000006060.
DR   GeneID; 101024628; -.
DR   CTD; 56300; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; VITCKYP; -.
DR   Proteomes; UP000028761; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   168 AA;  18601 MW;  652AA58876BE5BAA CRC64;
     MRGTPGNPAG GGRVVYQSMR TPITGTINDL NQQVWTLQGQ ILVAVPRSDS VTPVTVAVIT
     CKYPEALDQS RGDPIYLGIR NPEMCFCCEE VGGQPTLQLK EQKIMDLYGQ PEPVKPFLFY
     RVKTGRTSTL ESVAFPNWFI ASSTRDQPII LTSELGKSYN TAFELNIK
//
ID   A0A096NEW4_PAPAN        Unreviewed;       184 AA.
AC   A0A096NEW4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 9.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000011450};
DE   Flags: Fragment;
GN   Name=IL36A {ECO:0000313|Ensembl:ENSPANP00000011450};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011450, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000011450}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000011450}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ01196747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000024005; ENSPANP00000011450; ENSPANG00000019900.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; PGWFIAV; -.
DR   Proteomes; UP000028761; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSPANP00000011450}.
SQ   SEQUENCE   184 AA;  20598 MW;  88F3242C066ECF12 CRC64;
     KRPIPPQSTV HLLGAPTLRI LKQHHHNAKM SKSEMPQPVS IQDINHRVWV LQDQILIAVP
     RKDRVSPVTI SLISCRHVET LEKDRGNPIY LGLNGLNLCL MCAKAGDQPT LQLKEKDIMD
     LYNQPEPVKS FLFYHSQSGR NSTFESVAFP GWFIAVSSEG GCPLILTQEL GKANTTDFGL
     TMLF
//
ID   A0A096NEW5_PAPAN        Unreviewed;       180 AA.
AC   A0A096NEW5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 9.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000011451};
DE   Flags: Fragment;
GN   Name=IL36B {ECO:0000313|Ensembl:ENSPANP00000011451};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011451, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000011451}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000011451}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ01196744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000023753; ENSPANP00000011451; ENSPANG00000009535.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; FQSVSYP; -.
DR   Proteomes; UP000028761; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSPANP00000011451}.
SQ   SEQUENCE   180 AA;  20523 MW;  BEE07FE363CF966E CRC64;
     KLAWKYLHLT SPKTIGWKDP YHLLSYQWQA APKSYAIRDS RQMVWVLSGN SLIAAPLSNS
     VKPVTLHLIT CRDTEFSDKK KGNLVYLGIK GKDLCLFCAE IQANLLCSLR EKNIMDLYME
     KKAQKPFLFF HNKEGSSSVF QSVSYPGWFI ATSSTSGQPI FLTRERGITN NTNFYLDSVE
//
ID   A0A096NEW6_PAPAN        Unreviewed;       155 AA.
AC   A0A096NEW6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000011452};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSPANP00000011452};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011452, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000011452}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000011452}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ01196744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003909200.1; XM_003909151.2.
DR   RefSeq; XP_009183231.1; XM_009184967.1.
DR   RefSeq; XP_009183232.1; XM_009184968.1.
DR   Ensembl; ENSPANT00000010145; ENSPANP00000011452; ENSPANG00000007246.
DR   GeneID; 101025682; -.
DR   CTD; 26525; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; MKDSALK; -.
DR   Proteomes; UP000028761; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  16908 MW;  E13F2B870D866696 CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
     VQGGSQCLSC GAGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAHPGWF
     LCTVPEADQP VRLTQLPDNA GWNAPITDFY FQQCD
//
ID   A0A096NEW8_PAPAN        Unreviewed;       152 AA.
AC   A0A096NEW8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 10.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000011454};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSPANP00000011454};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011454, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000011454}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000011454}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ01196744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003909201.2; XM_003909152.2.
DR   RefSeq; XP_009183230.1; XM_009184966.1.
DR   Ensembl; ENSPANT00000024312; ENSPANP00000011454; ENSPANG00000010208.
DR   GeneID; 101026034; -.
DR   CTD; 84639; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; AAWPGWF; -.
DR   Proteomes; UP000028761; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16789 MW;  1364CDEADEC82FC8 CRC64;
     MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICILPNRGL DRTKVPIFLG
     IQGGSCCLAC VETGEGPSVQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAARPGW
     FLCGPAEPQQ PVQLTKESEP SARTEFYFEQ SR
//
ID   A0A096NPG5_PAPAN        Unreviewed;       271 AA.
AC   A0A096NPG5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-MAY-2016, entry version 12.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000014895};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSPANP00000014895};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000014895, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000014895}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000014895}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ01196754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003909193.1; XM_003909144.2.
DR   RefSeq; XP_009183224.1; XM_009184960.1.
DR   RefSeq; XP_009183225.1; XM_009184961.1.
DR   Ensembl; ENSPANT00000013269; ENSPANP00000014895; ENSPANG00000009536.
DR   GeneID; 101023088; -.
DR   CTD; 3552; -.
DR   GeneTree; ENSGT00390000013353; -.
DR   OMA; NQKSFYD; -.
DR   Proteomes; UP000028761; Chromosome 13.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   271 AA;  30682 MW;  0304331C74668161 CRC64;
     MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYDVSY GPLHEGCMDQ SVSLSISEIS
     KTSKLSFKQS MVVVSTNGKV LKKRRLSLSQ SIADDHLEAI ANDSEEEIIK PRSAPFSFLS
     NMTYHFIRII KHEFILNDTL NQTIIRANDQ YLTAAAIHNL DEAVKFDMGA YTSSKDDTKV
     PVILRISKTQ LYVSAQDEDQ PVLLKEMPEI PKTITGSETN FLFFWETHGT KNYFISVAHP
     NLFIATKHDN WVCLAKGLPS ITDFQILENQ A
//
ID   A0A0A0MPZ0_FELCA        Unreviewed;       267 AA.
AC   A0A0A0MPZ0;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|Ensembl:ENSFCAP00000005482};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSFCAP00000005482};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000005482, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000005482, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005482,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of SAA cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000005482}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005482};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000005482}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005482};
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000005482}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AANG02054283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000005482; -.
DR   Ensembl; ENSFCAT00000005904; ENSFCAP00000005482; ENSFCAG00000005899.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   OMA; SNDKIPV; -.
DR   Proteomes; UP000011712; Chromosome A3.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   267 AA;  30362 MW;  92AB82CA4B5DB05A CRC64;
     MAAVPELTSE MMAYYSDEND LFFEADGPEK MKGSLQNLSH SFLGDEGIQL QISHQPDNKS
     LRHAVSVIVA MEKLKKISFP CSQPLQDEDL KSLFCCIFEE EPIICDTWDD GFVCDAAIQS
     QDYTFRDISQ KSLVLSGSYE LRALHLNGQN MNQQVVFRMS FVHGEENSKK IPVVLCIKKN
     NLYLSCVMKD GKPTLQLEML DPKVYPKKKM EKRFVFNKTE IKGNVEFESS QFPNWYISTS
     QAEEMPVFLG NTKGGQDITD FIMESAS
//
ID   A0A0A0MPZ7_FELCA        Unreviewed;       270 AA.
AC   A0A0A0MPZ7;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|Ensembl:ENSFCAP00000007503};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSFCAP00000007503};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000007503, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000007503, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007503,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of SAA cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000007503}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007503};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000007503}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007503};
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000007503}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AANG02054278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006930331.1; XM_006930269.2.
DR   RefSeq; XP_006930332.1; XM_006930270.2.
DR   STRING; 9685.ENSFCAP00000007503; -.
DR   Ensembl; ENSFCAT00000008097; ENSFCAP00000007503; ENSFCAG00000008095.
DR   GeneID; 493944; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   OMA; NQKSFYD; -.
DR   Proteomes; UP000011712; Chromosome A3.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    108       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   270 AA;  30798 MW;  1A43E1798B42EF36 CRC64;
     MAKVPDLFED LKNCYSENEE YSSEIDHLTL NQKSFYDASY DPLHEDCTDK FMSPSTSETS
     KTPQLTLKKS VVMVAANGKI LKKRRLSLNQ FLTADDLEAI ANEVEEEIMK PRSVAPNFYS
     SEKYNYQKII KSQFILNDNL SQSVIRKAGG KYLAAAALQN LDDAVKFDMG AYTSKEDSKL
     PVTLRISKTR LFVSAQNEDE PVLLKEMPET PKTIRDETNL LFFWERHGSK NYFKSVAHPK
     LFIATQEEKL VHMARGLPSV TDFQILETQS
//
ID   A0A0D9RVW2_CHLSB        Unreviewed;       177 AA.
AC   A0A0D9RVW2;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   11-MAY-2016, entry version 9.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000012751};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSCSAP00000012751};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012751, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000012751, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000012751}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000012751}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AQIB01144227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_008006617.1; XM_008008426.1.
DR   ProteinModelPortal; A0A0D9RVW2; -.
DR   Ensembl; ENSCSAT00000014790; ENSCSAP00000012751; ENSCSAG00000016706.
DR   GeneID; 103241288; -.
DR   CTD; 3557; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; IHGGKLC; -.
DR   Proteomes; UP000029965; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    177       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002345752.
SQ   SEQUENCE   177 AA;  19892 MW;  FB7938A968EF360F CRC64;
     MEICRGLGSH LICLLLFLFH SETVGRPSGR KPSKMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGPNVNLEEK IDVVPIEPHA LFLGIHGGKM CLSCVKSGDE TRLQLEAVNI TDLSKNRKQD
     KRFAFVRSDS GPTTSFESAA CPGWFLCTAM EADQPVSLTN MPDKGVMVTK FYFQEDE
//
ID   A0A0D9RVY4_CHLSB        Unreviewed;       152 AA.
AC   A0A0D9RVY4;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   11-MAY-2016, entry version 6.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000012773};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSCSAP00000012773};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012773, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000012773, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000012773}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000012773}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AQIB01144226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_008006616.1; XM_008008425.1.
DR   Ensembl; ENSCSAT00000014812; ENSCSAP00000012773; ENSCSAG00000016718.
DR   GeneID; 103241287; -.
DR   CTD; 84639; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; AAWPGWF; -.
DR   Proteomes; UP000029965; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16856 MW;  03692208C326C1B8 CRC64;
     MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICILPNRGL DRTKVPIFLG
     IQGGSRCLAC VETGEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAARPGW
     FLCGPAEPQQ PVQLTKESEP SARTEFYFEQ SR
//
ID   A0A0D9RVZ1_CHLSB        Unreviewed;       155 AA.
AC   A0A0D9RVZ1;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   11-MAY-2016, entry version 6.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000012780};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSCSAP00000012780};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012780, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000012780, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000012780}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000012780}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AQIB01144226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_008006613.1; XM_008008422.1.
DR   RefSeq; XP_008006614.1; XM_008008423.1.
DR   Ensembl; ENSCSAT00000014819; ENSCSAP00000012780; ENSCSAG00000016723.
DR   GeneID; 103241285; -.
DR   CTD; 26525; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; MKDSALK; -.
DR   Proteomes; UP000029965; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  16961 MW;  4ADB724A1157AB91 CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
     VQGGNQCLSC GAGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF
     LCTVPEADQP VRLTQLPDNA GWNAPITDFY FQQCD
//
ID   A0A0D9RVZ5_CHLSB        Unreviewed;       160 AA.
AC   A0A0D9RVZ5;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   11-MAY-2016, entry version 7.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000012784};
DE   Flags: Fragment;
GN   Name=IL36B {ECO:0000313|Ensembl:ENSCSAP00000012784};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012784, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000012784, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000012784}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000012784}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   EMBL; AQIB01144226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCSAT00000014823; ENSCSAP00000012784; ENSCSAG00000016731.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; FQSVSYP; -.
DR   Proteomes; UP000029965; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSCSAP00000012784}.
SQ   SEQUENCE   160 AA;  18036 MW;  37055FD683016731 CRC64;
     SKKEEELWQA APKSYAIRDS QQMVWVLSGN SLIAAPLSNS VKPVTLHLIT CRDTEFSDKK
     KGNLVYLGIK GKDLCLFCAE IQGKPTLQLK EKNIMDLYME KKAQKPFLFF HNKEGSSSVF
     QSVSYPGWFI ATSSTSGQPI FLTQERGITN NTNFYLDSVE
//
ID   A0A0D9RW05_CHLSB        Unreviewed;       160 AA.
AC   A0A0D9RW05;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   11-MAY-2016, entry version 7.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000012794};
DE   Flags: Fragment;
GN   Name=IL36A {ECO:0000313|Ensembl:ENSCSAP00000012794};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012794, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000012794, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000012794}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000012794}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AQIB01144225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCSAT00000014833; ENSCSAP00000012794; ENSCSAG00000016738.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; PGWFIAV; -.
DR   Proteomes; UP000029965; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSCSAP00000012794}.
SQ   SEQUENCE   160 AA;  17746 MW;  0FDF150AA47A71B3 CRC64;
     LTFSTVSKSE MPLPGSIQDI NHRVWVLQDQ ILIAVPRKDS VSPVTIALIS CRHVETLEKD
     RGNPIYLGLN GLNLCLMCAK DGDQPTLQLK EKDIMDLYNQ PEPVKSFLFY HSQSGRNSTF
     ESVAFPGWFI AVSSEGGCPL ILTQELGKAN TTDFGLTMLF
//
ID   A0A0D9RW12_CHLSB        Unreviewed;       170 AA.
AC   A0A0D9RW12;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   11-MAY-2016, entry version 6.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000012801};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSCSAP00000012801};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012801, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000012801, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000012801}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000012801}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AQIB01144225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCSAT00000014840; ENSCSAP00000012801; ENSCSAG00000016747.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; VITCKYP; -.
DR   Proteomes; UP000029965; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   170 AA;  18893 MW;  744E174E1C2000C2 CRC64;
     MRGTPGNPAG RGRVVYQSKS VRTPITGTIN DLNQQVWTLQ GQILVAVPRS DSVTPVTVAV
     ITCKYPEALD QSRGDPIYLG IRNPDMCLCC EKVGGQPTLQ LKEQKIMDLY DQPEPVKPFL
     FYRVKTGRTS TLESVAFPNW FIASSTRDQP IILTSELGKS YNTAFELNIK
//
ID   A0A0D9RW19_CHLSB        Unreviewed;       219 AA.
AC   A0A0D9RW19;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   11-MAY-2016, entry version 6.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000012808};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSCSAP00000012808};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012808, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000012808, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000012808}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000012808}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AQIB01144224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCSAT00000014847; ENSCSAP00000012808; ENSCSAG00000016752.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; RKHTEFS; -.
DR   Proteomes; UP000029965; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   219 AA;  24156 MW;  844EF25D655692C7 CRC64;
     MSFVGENSGV KMGSEDWEKD EPQCYSEKDP AGSPLEPGPS FPSMNFAHTS PKVKNLNPKK
     FSIHDRDHKV LVVDSGNLIA VPDKNYIRPE IFFALASSLS SASAEKGSPI LLGVSKGEFC
     LSCDKDKGQS HPSLQLKKKK LMKLAALKES ARRPFIFYRA QVGSRNTLES AAHPGWFICT
     SCNCNEPVAV TDKFENRKHI EFSFQPVCKA EMSPSEVSD
//
ID   A0A0D9RW29_CHLSB        Unreviewed;       224 AA.
AC   A0A0D9RW29;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   11-MAY-2016, entry version 7.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000012818};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSCSAP00000012818};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012818, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000012818, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000012818}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000012818}.
CC   -----------------------------------------------------------------------
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AQIB01144219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCSAT00000014857; ENSCSAP00000012818; ENSCSAG00000016761.
DR   GeneTree; ENSGT00390000013353; -.
DR   OMA; NQKSFYD; -.
DR   Proteomes; UP000029965; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1     62       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   224 AA;  25349 MW;  5E752E1EFC5827D7 CRC64;
     MDQSVSLSIY EISKTSKLTF KQSMVVVSTN GKVLKKRRLS LSQSITDNNL EAIANNSEEE
     IIKPRSAPFS FLSNVKYNFI RIIKHEFILN DALNQTIIRA NDQYLTAATI HNLDEAVKFD
     MGAYASSKDD TKVPVILRIS KTQLYLSAQD EDQPVLLKEM PEIPKTITGS ETNFLFFWET
     HGTKNYFVSV AHPNLFIATK HDNWVCLAKG LPSITDFQIV ENQA
//
ID   A0A0D9S2Y6_CHLSB        Unreviewed;       193 AA.
AC   A0A0D9S2Y6;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   11-MAY-2016, entry version 7.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAP00000015225};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSCSAP00000015225};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000015225, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000015225, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000015225}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000015225}.
CC   -----------------------------------------------------------------------
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AQIB01092341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01092342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01092343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01092344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01092345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_008019055.1; XM_008020864.1.
DR   RefSeq; XP_008019056.1; XM_008020865.1.
DR   RefSeq; XP_008019057.1; XM_008020866.1.
DR   RefSeq; XP_008019058.1; XM_008020867.1.
DR   ProteinModelPortal; A0A0D9S2Y6; -.
DR   Ensembl; ENSCSAT00000000837; ENSCSAP00000015225; ENSCSAG00000002819.
DR   GeneID; 103248464; -.
DR   CTD; 3606; -.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; PVFEDMP; -.
DR   Proteomes; UP000029965; Chromosome 1.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22325 MW;  B2BD29C033BB0B5E CRC64;
     MAAEPAEDNC INFVAMKFID STLYFIAEDD ENLESDYFGK LESKLSIIRN LNDQVLFIDQ
     GNRPLFEDMT DSDCRDNAPR TIFIINMYKD SQPRGMAVAI SVKCEKISTL SCENRIISFK
     EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLY KLILKKKDEL
     GDRSIMFTVQ NED
//
ID   A0A0G2K003_RAT          Unreviewed;       268 AA.
AC   A0A0G2K003;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   08-JUN-2016, entry version 8.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|Ensembl:ENSRNOP00000071252};
GN   Name=Il1a {ECO:0000313|Ensembl:ENSRNOP00000071252,
GN   ECO:0000313|RGD:2890};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000071252, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000071252, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071252,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000071252}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071252};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000071252}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AABR07053712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07053713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07072926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSRNOT00000080818; ENSRNOP00000071252; ENSRNOG00000004575.
DR   RGD; 2890; Il1a.
DR   GeneTree; ENSGT00390000013353; -.
DR   Reactome; R-RNO-446652; Interleukin-1 signaling.
DR   Proteomes; UP000002494; Chromosome 3.
DR   ExpressionAtlas; A0A0G2K003; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    108       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30698 MW;  9373B9BDEC0BCEDE CRC64;
     MAKVPDLFED LKNCYSENEE YSLDHLSLNQ KSFYDASYGS LHENCTDKFV SLRTSETSKM
     STFTFKESRV VVSATSNKGK ILKKRRLSFN QPFTEDDLEA IAHDLEETIQ PRSAPHSFQN
     NLRYKLIRIV KQEFIMNDSL NQNIYVDMDR IHLKAASLND LQLEVKFDMY AYSSGGDDSK
     YPVTLKVSNT QLFVSAQGED KPVLLKEIPE TPKLITGSET DLIFFWEKIN SKNYFTSAAF
     PELLIATKEQ SQVHLARGLP SMIDFQIS
//
ID   A0T125_CANLF            Unreviewed;       207 AA.
AC   A0T125;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   11-MAY-2016, entry version 46.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|Ensembl:ENSCAFP00000042694};
DE   SubName: Full=Interleukin-1 alpha isoform {ECO:0000313|EMBL:ABK59324.1};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSCAFP00000042694};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|EMBL:ABK59324.1};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000042694, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000042694,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|EMBL:ABK59324.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Soller J.T., Murua Escobar H., Janssen M., Fork M., Bullerdiek J.,
RA   Nolte I.;
RT   "Cytokine Genes Single Nucleotide Polymorphism (SNP) Screening
RT   Analyses in Canine Malignant Histiocytosis.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSCAFP00000042694}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000042694};
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAEX03010912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EF068230; ABK59324.1; -; mRNA.
DR   RefSeq; XP_005630123.1; XM_005630066.2.
DR   UniGene; Cfa.3645; -.
DR   Ensembl; ENSCAFT00000042801; ENSCAFP00000042694; ENSCAFG00000007245.
DR   GeneID; 403782; -.
DR   CTD; 3552; -.
DR   GeneTree; ENSGT00390000013353; -.
DR   HOVERGEN; HBG002432; -.
DR   Reactome; R-CFA-446652; Interleukin-1 signaling.
DR   Proteomes; UP000002254; Chromosome 17.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    102       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   207 AA;  23865 MW;  C60413345EDA9D26 CRC64;
     MAKVPDLFED LKNCYSENEE YSSEIDHLSL NQKSFYDMSC DPLHEDCMSL STSEISKTSQ
     LTFKENVVVV AANGKILKKR RLSLSQFITD DDLEDIANDT EEVKFDMGAY TSEDSKLPVT
     LRISKTRLFV SAQNEDEPVL LKEMPETPKT IRDETNLLFF WERHGSKHYF KSVAQPKLFI
     ATQERKLVHM ARGQPSITDF RLLETQP
//
ID   A3DTN5_MELGA            Unreviewed;       267 AA.
AC   A3DTN5;
DT   20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   20-MAR-2007, sequence version 1.
DT   06-JUL-2016, entry version 61.
DE   SubName: Full=IL-1 beta {ECO:0000313|EMBL:ABD49202.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMGAP00000003322};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSMGAP00000003322};
OS   Meleagris gallopavo (Common turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1] {ECO:0000313|EMBL:ABD49202.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17275099; DOI=10.1016/j.vetimm.2006.12.010;
RA   Wu Y.F., Liu H.J., Chiou S.H., Lee L.H.;
RT   "Sequence and phylogenetic analysis of interleukin (IL)-1beta-encoding
RT   genes of five avian species and structural and functional homology
RT   among these IL-1beta proteins.";
RL   Vet. Immunol. Immunopathol. 116:37-46(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000003322, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMGAP00000003322}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DQ393271; ABD49202.1; -; mRNA.
DR   RefSeq; NP_001290147.1; NM_001303218.1.
DR   UniGene; Mga.4316; -.
DR   Ensembl; ENSMGAT00000004022; ENSMGAP00000003322; ENSMGAG00000003598.
DR   GeneID; 100034741; -.
DR   KEGG; mgp:100034741; -.
DR   CTD; 3557; -.
DR   GeneTree; ENSGT00510000048687; -.
DR   HOVERGEN; HBG007328; -.
DR   KO; K04519; -.
DR   Proteomes; UP000001645; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0006953; P:acute-phase response; IDA:AgBase.
DR   GO; GO:0032602; P:chemokine production; IMP:AgBase.
DR   GO; GO:0043400; P:cortisol secretion; ISS:AgBase.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN       34     92       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   267 AA;  29538 MW;  6337D7A2B5C9D8D8 CRC64;
     MAFVPDLDVL ESSSLSEETF YGPSCLCLQK KPRLDSEHTA VGVQVTVRKG RGARSFRQAA
     VLVVAMTKLL RRPTRRDFAD SDLSALLEEV FEPVTFQRLE SSYAGAPAFR YTRSQSFDIF
     DINQKCFVLE SPTQLVALHL QGPSSSQKVR LNIALYRPRG PRGSAGAGQT PVALGIKGYK
     LYMSCVLSGA EPTLQLEEAD VTRDIDSAEL TRFVFYRLDS PAEGTTRFES AAFPGWFICT
     SLQPRQPVGI TNRPDQVNIA TYKLSGR
//
ID   B1AB80_HORSE            Unreviewed;       268 AA.
AC   B1AB80;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   11-MAY-2016, entry version 45.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:ABZ91976.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000000048};
DE   Flags: Fragment;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1] {ECO:0000313|EMBL:ABZ91976.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Tompkins D., Hudgens T., Horohov D., Wagner B., Baldwin C.;
RT   "U.S. Veterinary Immune Reagent Network: Expressed Equine Gene
RT   Sequences.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000000048, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000048,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [3] {ECO:0000313|Ensembl:ENSECAP00000000048}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000048};
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
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DR   EMBL; EU438767; ABZ91976.1; -; mRNA.
DR   UniGene; Eca.13475; -.
DR   STRING; 9796.ENSECAP00000000048; -.
DR   Ensembl; ENSECAT00000000066; ENSECAP00000000048; ENSECAG00000000051.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Cytokine {ECO:0000256|RuleBase:RU003753};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
FT   NON_TER     268    268       {ECO:0000313|EMBL:ABZ91976.1}.
SQ   SEQUENCE   268 AA;  30340 MW;  5788E36576D1DDF9 CRC64;
     MAAVPDTSDM MTYCSGNEND LFFEEDGPKQ MKGSFQDLDL SSMGDGGIQL QFSHQLYNKT
     FKHVVSIIVA MEKLKKIPVP CSQAFQDDDL RSLFSVIFEE EPIICDNWDD DYVCDAAVHS
     VNCRLRDIYH KSLVLSGACE LQAVHLNGEN TNQQVVFCMS FVQGEEETDK IPVALGLKEK
     NLYLSCGMKD GKPTLQLETV DPNTYPKRKM EKRFVFNKME IKGNVEFESA MYPNWYISTS
     QAEKKPVFLG NTRGGRDITD FIMEITSA
//
ID   B6E127_CHLSB            Unreviewed;       269 AA.
AC   B6E127; A0A0D9RW24;
DT   25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 3.
DT   11-MAY-2016, entry version 35.
DE   SubName: Full=Interleukin-1beta {ECO:0000313|EMBL:ACI28917.1};
GN   Name=IL-1beta {ECO:0000313|EMBL:ACI28917.1};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|EMBL:ACI28917.1, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; FJ194490; ACI28917.1; -; mRNA.
DR   Ensembl; ENSCSAT00000014852; ENSCSAP00000012813; ENSCSAG00000016756.
DR   HOVERGEN; HBG007328; -.
DR   Proteomes; UP000029965; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   269 AA;  30501 MW;  ABC545D06AF59D69 CRC64;
     MAEVPELTSE MMAYYSGNED DLFFEVDGPK QMKCSFQDLD LCPLDGGIQL QISHEHYNKG
     FRQAVSVVVA MEKLRKMLVP CPQTFQDNDL STLIPFIFEE EPIFLDTSNN DACVHDAPVR
     SLHCTLRDAQ LKSLVMSGPY ELKALHLQGQ DLEQQVVFSM SFVQGEESND KVPVALGLKA
     KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST
     SQAENMPVFL GGTRGGQDIT DFTMQFVSS
//
ID   C9JTH1_HUMAN            Unreviewed;       117 AA.
AC   C9JTH1;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-JUN-2016, entry version 47.
DE   SubName: Full=Interleukin-36 receptor antagonist protein {ECO:0000313|Ensembl:ENSP00000409262};
DE   Flags: Fragment;
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSP00000409262};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409262, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000409262, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000409262}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000409262}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AC016724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; C9JTH1; -.
DR   STRING; 9606.ENSP00000259212; -.
DR   PaxDb; C9JTH1; -.
DR   PRIDE; C9JTH1; -.
DR   Ensembl; ENST00000437409; ENSP00000409262; ENSG00000136695.
DR   UCSC; uc061nbp.1; human.
DR   HGNC; HGNC:15561; IL36RN.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOGENOM; HOG000231506; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; C9JTH1; -.
DR   ExpressionAtlas; C9JTH1; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C9JTH1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER     117    117       {ECO:0000313|Ensembl:ENSP00000409262}.
SQ   SEQUENCE   117 AA;  12623 MW;  0BF67F8440C8F433 CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
     VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYP
//
ID   D4A1A6_RAT              Unreviewed;       156 AA.
AC   D4A1A6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   06-JUL-2016, entry version 56.
DE   SubName: Full=Interleukin 1 family, member 5 (Delta) (Predicted), isoform CRA_a {ECO:0000313|EMBL:EDL93666.1};
DE   SubName: Full=Protein Il36rn {ECO:0000313|Ensembl:ENSRNOP00000007593};
GN   Name=Il36rn {ECO:0000313|Ensembl:ENSRNOP00000007593,
GN   ECO:0000313|RGD:1311212};
GN   Synonyms=Il1f5_predicted {ECO:0000313|EMBL:EDL93666.1};
GN   ORFNames=rCG_45585 {ECO:0000313|EMBL:EDL93666.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000007593, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000007593, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007593,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|EMBL:EDL93666.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL93666.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [3] {ECO:0000313|EMBL:EDL93666.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL93666.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA   Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA   Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSRNOP00000007593}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007593};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [5] {ECO:0000313|Ensembl:ENSRNOP00000072715}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072715};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AABR07051213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH474001; EDL93666.1; -; Genomic_DNA.
DR   EMBL; CH474001; EDL93667.1; -; Genomic_DNA.
DR   EMBL; CH474001; EDL93668.1; -; Genomic_DNA.
DR   RefSeq; NP_001101284.1; NM_001107814.1.
DR   RefSeq; XP_008759808.1; XM_008761586.1.
DR   RefSeq; XP_008759809.1; XM_008761587.1.
DR   UniGene; Rn.63170; -.
DR   Ensembl; ENSRNOT00000007593; ENSRNOP00000007593; ENSRNOG00000005751.
DR   Ensembl; ENSRNOT00000091805; ENSRNOP00000072715; ENSRNOG00000005751.
DR   GeneID; 311783; -.
DR   KEGG; rno:311783; -.
DR   UCSC; RGD:1311212; rat.
DR   CTD; 26525; -.
DR   RGD; 1311212; Il36rn.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   KO; K05483; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   156 AA;  17138 MW;  BB15C7091DF5E7B0 CRC64;
     MMVLSGALCF RMKDSALKVL YLHNNQLLAG GLHAGKVIKG EEISVVPNRA LDASLSPVIL
     GVQGGSQCLS CGTEKEPILK LEPVNIMELY LGTKESKSFT FYRRDLGLTS SFESAAYPGW
     FLCTSPEADQ PVRLTQISED PAWDAPITDF YFQQCD
//
ID   D4A1I2_RAT              Unreviewed;       160 AA.
AC   D4A1I2;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   06-JUL-2016, entry version 54.
DE   SubName: Full=Interleukin 1 family, member 6 (Predicted) {ECO:0000313|EMBL:EDL93670.1};
DE   SubName: Full=Protein Il36a {ECO:0000313|Ensembl:ENSRNOP00000007540};
GN   Name=Il36a {ECO:0000313|Ensembl:ENSRNOP00000007540,
GN   ECO:0000313|RGD:1306869};
GN   Synonyms=Il1f6_predicted {ECO:0000313|EMBL:EDL93670.1};
GN   ORFNames=rCG_45360 {ECO:0000313|EMBL:EDL93670.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000007540, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000007540, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007540,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|EMBL:EDL93670.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL93670.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [3] {ECO:0000313|EMBL:EDL93670.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL93670.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA   Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA   Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSRNOP00000007540}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007540};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AABR07051212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH474001; EDL93670.1; -; Genomic_DNA.
DR   RefSeq; NP_001100024.1; NM_001106554.1.
DR   RefSeq; XP_008759803.1; XM_008761581.1.
DR   UniGene; Rn.218666; -.
DR   Ensembl; ENSRNOT00000007540; ENSRNOP00000007540; ENSRNOG00000005722.
DR   GeneID; 296541; -.
DR   KEGG; rno:296541; -.
DR   UCSC; RGD:1306869; rat.
DR   CTD; 27179; -.
DR   RGD; 1306869; Il36a.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   KO; K05484; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-RNO-449147; Signaling by Interleukins.
DR   Proteomes; UP000002494; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   160 AA;  18109 MW;  A2EB04C785E1B4E9 CRC64;
     MNKDKELSAA TPWFRHIQDL SSRVWVLQDN ILTAVPRKEQ TVPVTITLLP CQYLDTLEKN
     KGDPMYLGVK KPQSCLSCTK NGEQPVLQLR EGNILDMYHQ KERVKASLFY HKKSGTTSTF
     ESAAFPGWFI AVCSKGSCPL VLTQELGKTF ITDFEMTVVH
//
ID   D4A6F3_RAT              Unreviewed;       179 AA.
AC   D4A6F3;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 2.
DT   06-JUL-2016, entry version 52.
DE   SubName: Full=Protein Il36b {ECO:0000313|Ensembl:ENSRNOP00000059138};
GN   Name=Il36b {ECO:0000313|Ensembl:ENSRNOP00000059138,
GN   ECO:0000313|RGD:1307847};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000059138, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000059138, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000059138,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000059138}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000059138};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000059138}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AABR07051213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006233676.1; XM_006233614.1.
DR   RefSeq; XP_006233677.1; XM_006233615.1.
DR   RefSeq; XP_006233678.1; XM_006233616.2.
DR   RefSeq; XP_006233679.1; XM_006233617.2.
DR   UniGene; Rn.137499; -.
DR   PaxDb; D4A6F3; -.
DR   PeptideAtlas; D4A6F3; -.
DR   Ensembl; ENSRNOT00000067207; ENSRNOP00000059138; ENSRNOG00000043323.
DR   GeneID; 362076; -.
DR   UCSC; RGD:1307847; rat.
DR   CTD; 27177; -.
DR   RGD; 1307847; Il36b.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-RNO-449147; Signaling by Interleukins.
DR   Proteomes; UP000002494; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   179 AA;  19966 MW;  BED5F0D39AE77C1B CRC64;
     MMAFPPQSHV CFTPPKSSDF DNINKGVQAF PSTYRVHDSQ HKAWVLAGNS LTAVPASNSV
     KSVILSLIAC RDMEFQDEKK GNLVFLGIKG RSLCLFCAEI EGKPTLQLKD VDIMDLYNEK
     KAQKAFLFYH GIEGSTSVFQ SVLYPGWFIA TSSTARQTII LTQERGEANN TNFYLESEN
//
ID   D4A9I5_RAT              Unreviewed;       152 AA.
AC   D4A9I5;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   06-JUL-2016, entry version 50.
DE   SubName: Full=Interleukin 1 family, member 10 (Predicted) {ECO:0000313|EMBL:EDL93665.1};
DE   SubName: Full=Protein Il1f10 {ECO:0000313|Ensembl:ENSRNOP00000007675};
GN   Name=Il1f10 {ECO:0000313|Ensembl:ENSRNOP00000007675,
GN   ECO:0000313|RGD:1305635};
GN   Synonyms=Il1f10_predicted {ECO:0000313|EMBL:EDL93665.1};
GN   ORFNames=rCG_45898 {ECO:0000313|EMBL:EDL93665.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000007675, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000007675, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007675,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|EMBL:EDL93665.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL93665.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [3] {ECO:0000313|EMBL:EDL93665.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL93665.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA   Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA   Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSRNOP00000007675}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007675};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AABR07051213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH474001; EDL93665.1; -; Genomic_DNA.
DR   RefSeq; NP_001102041.1; NM_001108571.1.
DR   UniGene; Rn.84164; -.
DR   STRING; 10116.ENSRNOP00000007675; -.
DR   Ensembl; ENSRNOT00000007675; ENSRNOP00000007675; ENSRNOG00000005800.
DR   GeneID; 362077; -.
DR   KEGG; rno:362077; -.
DR   UCSC; RGD:1305635; rat.
DR   CTD; 84639; -.
DR   RGD; 1305635; Il1f10.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  17081 MW;  7E69E146FF3FDE83 CRC64;
     MCSLPMARYY IIKDAYQKAL YTRNGQLLVG DPDSENCEPE KVCVLPNRGL DRSKVPIFLG
     IQGGSCCLAC VKTREGPLLQ LEDVNIEDLY KGGEQTTRFT FFQRSLGSAF RLEAAACPGW
     FLCGPAEPQQ PVQLIQESEP STRTEFYFEQ SR
//
ID   D6RR58_CAVPO            Unreviewed;       193 AA.
AC   D6RR58;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   11-MAY-2016, entry version 34.
DE   SubName: Full=IL-18 {ECO:0000313|EMBL:BAC76898.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000002879};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSCPOP00000002879};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [1] {ECO:0000313|EMBL:BAC76898.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hartley {ECO:0000313|EMBL:BAC76898.1};
RA   Shiratori I., Seya T.;
RT   "Cloning of cDNA for Guinea pig IL-18.";
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000002879, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002879,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSCPOP00000002879}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002879};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02024895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB025722; BAC76898.1; -; mRNA.
DR   RefSeq; NP_001244167.1; NM_001257238.1.
DR   RefSeq; XP_005004943.1; XM_005004886.2.
DR   STRING; 10141.ENSCPOP00000002879; -.
DR   Ensembl; ENSCPOT00000003222; ENSCPOP00000002879; ENSCPOG00000003179.
DR   GeneID; 100734451; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22376 MW;  86CADE9A5C7A6599 CRC64;
     MAVSDSENDC INFVKMKFID SILYFIPEND DNLESDYFGR IEHHLSIIRN LKNQVLFIDR
     KKQPVFEDMP DSDCADNEPY TTFNIHVYKD SNARGVPVAI SVTCNGNHTL SCEDKTISFK
     EINPPDNIND TKSDIIFFQR SVPGHDDKMQ FESSLYKGYF LACQKERNIY KLILKNKDEY
     GDKSVMFTVQ NND
//
ID   E1BD32_BOVIN            Unreviewed;       152 AA.
AC   E1BD32;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   08-JUN-2016, entry version 38.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000023975};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSBTAP00000023975};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000023975, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000023975, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023975,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000023975}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023975};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000023975}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02031091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001180014.1; NM_001193085.1.
DR   UniGene; Bt.106467; -.
DR   STRING; 9913.ENSBTAP00000023975; -.
DR   PaxDb; E1BD32; -.
DR   Ensembl; ENSBTAT00000023975; ENSBTAP00000023975; ENSBTAG00000018012.
DR   GeneID; 615702; -.
DR   KEGG; bta:615702; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; E1BD32; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  17055 MW;  7FCB8408626D6A82 CRC64;
     MCSLPMAKYY IIKDAEQKAL YMRDGQFLVG DPNADNCHAE TICILPNRGL ERTKFPIFLG
     VQGGSRCLAC VETGEGPSLQ LEDVNIEDLY KGGEEATRFT FFQRSSGPAF RLEAAAWPGW
     FLSGSSEPQQ PLRLTKESEP SARTEFYFEQ SR
//
ID   E1BLE5_BOVIN            Unreviewed;       205 AA.
AC   E1BLE5;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   08-JUN-2016, entry version 40.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000029311};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSBTAP00000029311};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000029311, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000029311, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029311,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000029311}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029311};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000029311}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02031089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001254156.5; XM_001254155.6.
DR   RefSeq; XP_002691443.4; XM_002691397.5.
DR   UniGene; Bt.75805; -.
DR   STRING; 9913.ENSBTAP00000029311; -.
DR   PaxDb; E1BLE5; -.
DR   Ensembl; ENSBTAT00000029311; ENSBTAP00000029311; ENSBTAG00000013675.
DR   GeneID; 786493; -.
DR   KEGG; bta:786493; -.
DR   CTD; 27178; -.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; E1BLE5; -.
DR   KO; K05485; -.
DR   OMA; RKHTEFS; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-BTA-449147; Signaling by Interleukins.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   205 AA;  22867 MW;  0A30EC3767C4C148 CRC64;
     MSVLEENPGM KMDCEDWERD EPQCSSEDSV RDALEPGPSL TSMSAAHAGP RVKANGPEKF
     TIHDGDQKVL VLDSKTLRAV PDKTYILPEI FFVLASRVKS AYENKGSPIF LAVSKGQLCL
     CCDTNKGHKP SLQLKKKKLS KLAAQKKGKY LPFIFYRNKV GSRNTLESAA HPGWFVCTFP
     NPGKPVGMTK SHGRRKHTEF SFRRI
//
ID   E1BPL0_BOVIN            Unreviewed;       159 AA.
AC   E1BPL0;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   08-JUN-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000002694};
GN   Name=IL36A {ECO:0000313|Ensembl:ENSBTAP00000002694};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000002694, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000002694, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002694,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000002694}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002694};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000002694}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02031090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; E1BPL0; -.
DR   Ensembl; ENSBTAT00000002694; ENSBTAP00000002694; ENSBTAG00000002087.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   OrthoDB; EOG7034JW; -.
DR   Reactome; R-BTA-449147; Signaling by Interleukins.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   159 AA;  17932 MW;  F3F22FE9D1673870 CRC64;
     MEKVLSRIHP ILVNIQDINH LVWVLQGQTL TAVPRKDQMD PVTVTLVSCK YTETLEKGRG
     NPVYLGLKEP ELCLFCTKVK GQPTLQLQER NIMDLYHQTE PVKPFLFYHD QNGRASSFES
     VAFPGWFIGS CSCGGCPVII TQELGKIYTT DFGFTVLQP
//
ID   E2R865_CANLF            Unreviewed;       149 AA.
AC   E2R865;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   08-JUN-2016, entry version 37.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000010781};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSCAFP00000010781};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000010781, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000010781, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000010781,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000010781}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000010781};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000010781}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAEX03010913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; E2R865; -.
DR   Ensembl; ENSCAFT00000011635; ENSCAFP00000010781; ENSCAFG00000007271.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; E2R865; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-CFA-449147; Signaling by Interleukins.
DR   Proteomes; UP000002254; Chromosome 17.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   149 AA;  17132 MW;  F3C95848D5775C4F CRC64;
     PRIFGVYDSL QMVWVLKENS LIATPFSRNV KPVHLDLTTC TDKEFHDAGK GNPVYLGIKG
     HHLCLFCAEI QGQPSLQLKE KKIMDMYREK KAQKPFLFFH SREGSTSVFQ SVSYPDWFIG
     TSKMVGHPVI LTKERGKNHN TNFYLEPED
//
ID   E2R8Z2_CANLF            Unreviewed;       214 AA.
AC   E2R8Z2;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   08-JUN-2016, entry version 36.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000010776};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSCAFP00000010776};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000010776, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000010776, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000010776,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000010776}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000010776};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000010776}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAEX03010913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005630505.1; XM_005630448.2.
DR   STRING; 9615.ENSCAFP00000010776; -.
DR   PaxDb; E2R8Z2; -.
DR   Ensembl; ENSCAFT00000011629; ENSCAFP00000010776; ENSCAFG00000007263.
DR   GeneID; 100686057; -.
DR   KEGG; cfa:100686057; -.
DR   CTD; 27178; -.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; E2R8Z2; -.
DR   KO; K05485; -.
DR   OMA; RKHTEFS; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-CFA-449147; Signaling by Interleukins.
DR   Proteomes; UP000002254; Chromosome 17.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   214 AA;  23846 MW;  CAD8BE4B77310E18 CRC64;
     MSFLEDSGVK MESEDWERDE PHGCSEDLAR SPLEPGPSLT SISSAHSCPK VKVSYPEKFS
     IHDRDHKVLV LDCDTLRAVP FKTYIRPEMF FVLASSLSSA SKEKGSPILL AVCKGELCLC
     CEKDRRQSQP SLQLKKKKLT NLAAQKESAR QPFIFYRTKV GSQNRLESAA HPGWFICTSR
     NSGEPVGVTN VLGKRKHTEF SFHRAETSPS EVSG
//
ID   E7F2E6_DANRE            Unreviewed;       356 AA.
AC   E7F2E6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-JUN-2016, entry version 37.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDARP00000105999};
GN   Name=il1fma {ECO:0000313|Ensembl:ENSDARP00000105999,
GN   ECO:0000313|ZFIN:ZDB-GENE-140106-231};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000105999, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000105999}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000105999};
RG   Ensembl;
RL   Submitted (APR-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000105999, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000105999,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000105999}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CU652893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; E7F2E6; -.
DR   Ensembl; ENSDART00000127049; ENSDARP00000105999; ENSDARG00000089383.
DR   ZFIN; ZDB-GENE-140106-231; il1fma.
DR   eggNOG; ENOG410JGPV; Eukaryota.
DR   eggNOG; ENOG410YT8P; LUCA.
DR   GeneTree; ENSGT00390000016316; -.
DR   InParanoid; E7F2E6; -.
DR   OMA; ITIYYYK; -.
DR   OrthoDB; EOG7M6D88; -.
DR   Proteomes; UP000000437; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   356 AA;  39567 MW;  4A092B69921369E1 CRC64;
     MAAEGSPVCG GVKLFHTECA GKHLYEVKGF LNHNKGMFTS TGDKLLMINN TNVEDLTPTS
     LADLLTEGSA LLTIHHPSKN KSNEECESEE LRVDSKERTV MSFSLLMVRD VELEADVIPE
     SDSECEDEIE DKLFSDKNLL IVSMEDASFN MVVARGCDPD NPCNDCGKTN CQLNEVVVLP
     TNAKISSCSA KVLHFKKEKK NLFLKSLFNE KYVTPDNRQI CLSSTMSAPI TIYSYRVNSV
     DNPGVPVVLN FTGTQNFFSC TTKQGADTKI LTVVSYSKSE LQKICAGDTE KWSLVFYKSC
     GPDCFQRFES ALHRGWFICT KNIANNDANV YMGKGVERDK PLNTFFVIIE SEKAIC
//
ID   F1LQB1_RAT              Unreviewed;       267 AA.
AC   F1LQB1;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 3.
DT   08-JUN-2016, entry version 41.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|Ensembl:ENSRNOP00000006113};
GN   Name=Il1a {ECO:0000313|Ensembl:ENSRNOP00000006113,
GN   ECO:0000313|RGD:2890};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000006113, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000006113, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000006113,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000006113}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000006113};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000006113}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AABR07053712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07053713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07072926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10116.ENSRNOP00000006113; -.
DR   PaxDb; F1LQB1; -.
DR   Ensembl; ENSRNOT00000006113; ENSRNOP00000006113; ENSRNOG00000004575.
DR   RGD; 2890; Il1a.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   OrthoDB; EOG76473H; -.
DR   Reactome; R-RNO-446652; Interleukin-1 signaling.
DR   Proteomes; UP000002494; Chromosome 3.
DR   ExpressionAtlas; F1LQB1; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    107       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   267 AA;  30631 MW;  45010767C65CF9A6 CRC64;
     MAKVPDLFED LKNCYRETES SFYHLSLNQK SFYDASYGSL HENCTDKFVS LRTSETSKMS
     TFTFKESRVV VSATSNKGKI LKKRRLSFNQ PFTEDDLEAI AHDLEETIQP RSAPHSFQNN
     LRYKLIRIVK QEFIMNDSLN QNIYVDMDRI HLKAASLNDL QLEVKFDMYA YSSGGDDSKY
     PVTLKVSNTQ LFVSAQGEDK PVLLKEIPET PKLITGSETD LIFFWEKINS KNYFTSAAFP
     ELLIATKEQS QVHLARGLPS MIDFQIS
//
ID   F1MAF9_RAT              Unreviewed;       209 AA.
AC   F1MAF9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 3.
DT   08-JUN-2016, entry version 37.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|Ensembl:ENSRNOP00000006126};
GN   Name=Il1a {ECO:0000313|Ensembl:ENSRNOP00000006126,
GN   ECO:0000313|RGD:2890};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000006126, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000006126, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000006126,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000006126}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000006126};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000006126}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AABR07053712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07053713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07072926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSRNOT00000006126; ENSRNOP00000006126; ENSRNOG00000004575.
DR   RGD; 2890; Il1a.
DR   GeneTree; ENSGT00390000013353; -.
DR   Reactome; R-RNO-446652; Interleukin-1 signaling.
DR   Proteomes; UP000002494; Chromosome 3.
DR   ExpressionAtlas; F1MAF9; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    104       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   209 AA;  23765 MW;  92C1AE3C4F8EF720 CRC64;
     MAKVPDLFED LKNCYRETES SFYHLSLNQK SFYDASYGSL HENCTDKFVS LRTSETSKMS
     TFTFKESRVV VSATSNKGKI LKKRRLSFNQ PFTEDDLEAI AHDLEVKFDM YAYSSGGDDS
     KYPVTLKVSN TQLFVSAQGE DKPVLLKEIP ETPKLITGSE TDLIFFWEKI NSKNYFTSAA
     FPELLIATKE QSQVHLARGL PSMIDFQIS
//
ID   F1MPZ4_BOVIN            Unreviewed;       181 AA.
AC   F1MPZ4;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   08-JUN-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000032984};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000032984, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000032984, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000032984,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000032984}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000032984};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000032984}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02031089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9913.ENSBTAP00000032984; -.
DR   PaxDb; F1MPZ4; -.
DR   Ensembl; ENSBTAT00000033059; ENSBTAP00000032984; ENSBTAG00000039476.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F1MPZ4; -.
DR   OMA; LPFTFLK; -.
DR   OrthoDB; EOG7G4QHM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   181 AA;  20703 MW;  CC410955B3A002FC CRC64;
     PIPPLIIMNF PHTRPRVKSV TFKKCNIRDR NQQVLVLEGG VLKAVPDKDV TARDFIIITI
     RVVKPMNEEK NHIFLAVSKG ELCLYCDKVK RPKHPSLQLK KKHIKELSSL EAKDCLPFTF
     LKEQVDSYFT LESAANPGYF IYTSNKPGQP IGMTKELGQE KNIHFQFQEA KMELNPSPLS
     Q
//
ID   F1MWT5_BOVIN            Unreviewed;       155 AA.
AC   F1MWT5;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   08-JUN-2016, entry version 37.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000023970};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSBTAP00000023970};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000023970, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000023970, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023970,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000023970}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023970};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000023970}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02031091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; F1MWT5; -.
DR   Ensembl; ENSBTAT00000023970; ENSBTAP00000023970; ENSBTAG00000039839.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F1MWT5; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  17130 MW;  FEE419B95BB41B81 CRC64;
     MVLSGALCFR MKDAALKVLY LHDNQLLAGG LQAGKVIKGE EISVVPNRSL DAKLSPVILG
     VHSGSQCLSC GTGQEPTLKL EPVNIMELYH SAEKSKKFTF YRRDTGLTSS FESAAYPGWF
     LCTVPEADQP LQITQLPKDT SWDNPIIDFY FQQCD
//
ID   F1MYY4_BOVIN            Unreviewed;       174 AA.
AC   F1MYY4;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   08-JUN-2016, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000042793};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSBTAP00000042793};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000042793, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000042793, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000042793,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000042793}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000042793};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000042793}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02031090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002691394.1; XM_002691348.3.
DR   RefSeq; XP_002700826.1; XM_002700780.3.
DR   RefSeq; XP_010808391.1; XM_010810089.1.
DR   RefSeq; XP_010808392.1; XM_010810090.2.
DR   RefSeq; XP_010821861.1; XM_010823559.1.
DR   RefSeq; XP_010821862.1; XM_010823560.2.
DR   PaxDb; F1MYY4; -.
DR   Ensembl; ENSBTAT00000045402; ENSBTAP00000042793; ENSBTAG00000002085.
DR   GeneID; 615762; -.
DR   KEGG; bta:615762; -.
DR   CTD; 56300; -.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F1MYY4; -.
DR   KO; K05487; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-BTA-449147; Signaling by Interleukins.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   174 AA;  19492 MW;  4D61B2077E260E0A CRC64;
     MACFLGHDGG IHTSAMDCPR YVVVSDLSQQ VWFLQGQILV VVPRSNNVRP VTVTIIPCKY
     PECLEKDKGI PIYLGIKQPE MCLCCEDVGG KPELQLKNQK IMDLYNQAEP VKPFLFYRQS
     TGSTSTFESV AFPGWFIASS ERNQPIFLTS ELGNIYNTAF QLDSKEFSPS NNSL
//
ID   F1N2N4_BOVIN            Unreviewed;       183 AA.
AC   F1N2N4;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   08-JUN-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000002696};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSBTAP00000002696};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000002696, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000002696, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002696,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000002696}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002696};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000002696}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02031090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; F1N2N4; -.
DR   Ensembl; ENSBTAT00000002696; ENSBTAP00000002696; ENSBTAG00000002088.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F1N2N4; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-BTA-449147; Signaling by Interleukins.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   183 AA;  20813 MW;  EF6EA6F4E5A93544 CRC64;
     VQGWNPYKAS QELPPYTVLA EEPGHRIFHS LREYPSYLHI RDSRQMVWVV KGNSLIAVPS
     SNNIKPVILS LIACRDMEFN KEGNGTPHYL GIKDKNLCLY CTEIQGYPTL QLKEENIMNL
     YNKPKGEKCF LFYRNDEGST VVFQSVSYPG WFIATSSEAG HPVTLTKERG TVQSTNYYLE
     GGL
//
ID   F1PT49_CANLF            Unreviewed;       155 AA.
AC   F1PT49;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   08-JUN-2016, entry version 38.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000010784};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSCAFP00000010784};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000010784, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000010784, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000010784,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000010784}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000010784};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000010784}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAEX03010913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005630510.1; XM_005630453.1.
DR   ProteinModelPortal; F1PT49; -.
DR   PaxDb; F1PT49; -.
DR   Ensembl; ENSCAFT00000011639; ENSCAFP00000010784; ENSCAFG00000007272.
DR   GeneID; 611869; -.
DR   KEGG; cfa:611869; -.
DR   CTD; 26525; -.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F1PT49; -.
DR   KO; K05483; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002254; Chromosome 17.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  16981 MW;  E6101A0B05F15972 CRC64;
     MVLSGALCFR MKDAALKVLY LHDNQLLAGG LHAGKVIKGE EISVVPNRSL DAKLSPVILG
     VQGGSQCLSC GTGQEPTLKL EPVNIMELYL GAKESKSFTF YRRDTGLTSS FESAAYPGWF
     LCTVPEADQP LRLTQLSEDA SWDNPITDFY FQQCD
//
ID   F1SUB9_PIG              Unreviewed;       267 AA.
AC   F1SUB9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 2.
DT   08-JUN-2016, entry version 41.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000008635};
GN   Name=IL1B2 {ECO:0000313|Ensembl:ENSSSCP00000008635};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000008635, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000008635, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000008635};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000008635}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSSCP00000008635}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; FP015825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000008635; -.
DR   PaxDb; F1SUB9; -.
DR   Ensembl; ENSSSCT00000008860; ENSSSCP00000008635; ENSSSCG00000008087.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; F1SUB9; -.
DR   OMA; EVMANNG; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-SSC-446652; Interleukin-1 signaling.
DR   Reactome; R-SSC-448706; Interleukin-1 processing.
DR   Reactome; R-SSC-5660668; CLEC7A/inflammasome pathway.
DR   Proteomes; UP000008227; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    101       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   267 AA;  29865 MW;  4813E5783E4C1847 CRC64;
     MATVPEPAKE VMANNGDNNN DLLFEADGPK EMKCRTQNLD LSPLGDGSIQ LQISHQLCNE
     SSRPMVSVIV AKEKPMNPSS QVVCDDDPKS IFSSVFEEEP IVLEKHANGF LCDATPVQSV
     DCKLQDKDEK ALVLAGPHEL KALHLLTGDL KREVVFCMSF VQGDDSDDKI PVTLGIKGKN
     LYLSCVMKDD TPTLQLEDVD PKSYPKRDME KRFVFYKTEI KNRVEFESAL YPNWYISTSQ
     AEQKPVFLGN SKGRQDITDF TMEVLSP
//
ID   F6QEU5_HORSE            Unreviewed;       158 AA.
AC   F6QEU5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000015290};
GN   Name=IL36A {ECO:0000313|Ensembl:ENSECAP00000015290};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015290, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000015290, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015290,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000015290}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015290};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000015290}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   PaxDb; F6QEU5; -.
DR   Ensembl; ENSECAT00000018728; ENSECAP00000015290; ENSECAG00000017738.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6QEU5; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   158 AA;  17599 MW;  D4B65FA6E55C082F CRC64;
     FYTGLSVAVP IVGNIQDNNH LVWFLQGQTL LSVPGKHDKV PATVAIVPCK CLETLEKDRG
     NPIYLGVKEP EFCLFCTKVG DQPALELKKQ NIMELYNRPE PVKPFLFYHN QTGRTSTFES
     VAFPGWFIAA CATGDCPLIL TQELGKAYIT DFEFTTLA
//
ID   F6RH14_CALJA            Unreviewed;       268 AA.
AC   F6RH14;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 37.
DE   SubName: Full=Interleukin-1 beta proprotein {ECO:0000313|EMBL:JAB35514.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000030094};
GN   Name=IL1B {ECO:0000313|EMBL:JAB35514.1,
GN   ECO:0000313|Ensembl:ENSCJAP00000030094};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000030094, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000030094, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000030094}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:JAB35514.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAB35514.1};
RX   PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen
RT   mRNA sequences.";
RL   Gigascience 3:14-14(2014).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01139926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GAMQ01006337; JAB35514.1; -; mRNA.
DR   RefSeq; XP_008978532.1; XM_008980284.1.
DR   STRING; 9483.ENSCJAP00000030094; -.
DR   Ensembl; ENSCJAT00000031803; ENSCJAP00000030094; ENSCJAG00000016340.
DR   GeneID; 100406769; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008225; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30816 MW;  322834CDBB640A8D CRC64;
     MAEVPELTSE MMTYYSGNED DLFFEVDGPK QMKCSFQDLD LCPVDGGIQL RLSRQHYSKG
     FRQVVSVVVA MEKLRRMPVY CPQTFQDNDL STFFPFIFEE EPIIFDTWDN EAYVCDAPVR
     SLNCTLRDAQ QKCLVMSGPY ELKALHLQGQ DLEQQVVFSM SFVQGEESND KIPVALGLKE
     KNLYLSCVLK DKKPTLQLES VDPKNYPKKK MEKRFVFNKT EINNKLEFES AQFPNWYIST
     SQAENMPVFL GGTKGGQDIT DFTMQFVS
//
ID   F6SEZ4_MONDO            Unreviewed;       264 AA.
AC   F6SEZ4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017275};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSMODP00000017275};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017275, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000017275, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000017275}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000017275}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 13616.ENSMODP00000017275; -.
DR   Ensembl; ENSMODT00000017594; ENSMODP00000017275; ENSMODG00000013821.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; F6SEZ4; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        6     85       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   264 AA;  29846 MW;  5419DC057FDD6084 CRC64;
     MAETIMARVP DVLEALHSEN EGFISDIGQA SLGQDSFYPS FSSHHKERWS SPEFSKKAHQ
     LNFQEGMAAP VSQRKVKKKR RPFKNHYPSD NDSLPEKDKD VTKYAAASFA LQNKMDFRFI
     SYTFKQTLYD QMARGIIKTG KNLKAVPIQG STPEVIFDIG MYANLGPIPH YVIPVTLRIS
     NTNLYVAAGK EKEPVYLEEI PETPKWIDGS TSNILFYQLD PQNYCTFNSV ANPELYLATS
     PMEDQLMHMA EGLPSLIHFL VTDA
//
ID   F6SRL2_MACMU            Unreviewed;       133 AA.
AC   F6SRL2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000001327};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSMMUP00000001327};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000001327, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000001327, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001327,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000001327}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001327};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000001327}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSMMUT00000001410; ENSMMUP00000001327; ENSMMUG00000000989.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   ExpressionAtlas; F6SRL2; baseline.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   133 AA;  14749 MW;  98B18D8240EF06BF CRC64;
     MRGTPGNPAG GGRVVYQSIT VAVITCKYPE ALDQSRGDPI YLGIRNPEMC LCCEEVGGQP
     TLQLKEQKIM DLYGQPEPVK PFLFYRVKTG RTSTLESVAF PNWFIASSTR DQPIILTSEL
     GKSYNTAFEL NIK
//
ID   F6SRM1_MACMU            Unreviewed;       158 AA.
AC   F6SRM1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000001326};
GN   Name=IL36A {ECO:0000313|Ensembl:ENSMMUP00000001326};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000001326, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000001326, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001326,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000001326}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001326};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000001326}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSMMUT00000001409; ENSMMUP00000001326; ENSMMUG00000000988.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6SRM1; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   158 AA;  17531 MW;  7C514720F3E8C7E0 CRC64;
     FSTVSKSEMP QPVSIQDINH RVWVLQDQIL IAVPRKDGVS PVTISLISCR HVETLEKDRG
     NPIYLGLNGL NLCLMCAKAG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES
     VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF
//
ID   F6SRN0_MACMU            Unreviewed;       157 AA.
AC   F6SRN0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000001324};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSMMUP00000001324};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000001324, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000001324, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001324,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000001324}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001324};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000001324}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9544.ENSMMUP00000001323; -.
DR   Ensembl; ENSMMUT00000001407; ENSMMUP00000001324; ENSMMUG00000000986.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; FQSVSYP; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   157 AA;  17810 MW;  89322C901B9A004A CRC64;
     MNPQWQAAPK SYAIRDSRQM VWVLSGNSLI AAPLSNSVKP VTLHLITCRD TEFSDKKKGN
     LVYLGIRGKD LCFFCEEIQG KPTLQLKEKN IMDLYMEKKA QKPFLFFHNK EGSSSVFQSV
     SYPGWFIATS STSGQPIFLT QERGITNNTN FYLDSVE
//
ID   F6SSJ3_CALJA            Unreviewed;       216 AA.
AC   F6SSJ3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000045744};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSCJAP00000045744};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000045744, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000045744, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000045744}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000045744}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01027772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000056389; ENSCJAP00000045744; ENSCJAG00000017305.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000008225; Chromosome 19.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   216 AA;  24306 MW;  54C54B67D11840E0 CRC64;
     MSFVEENSGV KMGSEDLERD EPQCLSEDPV GSPLEPDPSL PFMSFVHSSP KLKNLNLKFS
     IHDQDHKVLV LDSGNIIAVP DKSYICPEIF FMLPTSLSSA SAEKGSPIHL GVSKEEFVYC
     DKDKDQSCPS LQLKKKKLMK LADQKESARR PFIFHRTQVG SQNLLESMVH PRWFVCTSCN
     CNEPVGVTDK HEHKKHTEFL FHPVCKAEMS PSEVSD
//
ID   F6SXC0_MONDO            Unreviewed;       276 AA.
AC   F6SXC0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017267};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSMODP00000017267};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017267, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000017267, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000017267}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000017267}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 13616.ENSMODP00000017267; -.
DR   Ensembl; ENSMODT00000017586; ENSMODP00000017267; ENSMODG00000013815.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; F6SXC0; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    114       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   276 AA;  31744 MW;  CFD796D977F86E5D CRC64;
     MATVPEMACD VMDFYSFFGF VYRDNDDSQF YEADGPNQKK QGHLQYPDLC SKKCLLEEDG
     IQLKFTAQSQ RFYRSVVVVV AIEKMRHLVE LSSGLFQDND LMNIFTSIFQ EEPITIKNCD
     IYEADFRFAS SGDYTIQDLD QKCLALTNAS ELKALHLSGP NISQQVIFSM KCYLGEVGSQ
     KTHVVLCIKK NNLYLSCVKR DGKPILQLEQ VDSFPKEDID KRFVFNKTEI NNKVEFESEE
     YPNWYISTSQ LDAQEVFLGN MRGGQEITNF FLDDLS
//
ID   F6SY64_MONDO            Unreviewed;       152 AA.
AC   F6SY64;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017259};
DE   Flags: Fragment;
GN   Name=LOC100026042 {ECO:0000313|Ensembl:ENSMODP00000017259};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017259, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000017259, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000017259}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000017259}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSMODT00000017578; ENSMODP00000017259; ENSMODG00000013808.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6SY64; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSMODP00000017259}.
SQ   SEQUENCE   152 AA;  16748 MW;  98E8EBC1EEAF2264 CRC64;
     VSGEQPRQRI VHDMEQQVWV LQGKILIGTP LNENVIPEKI LTISCRDDAY VNKDKGNAIY
     MGVKSNGLAL SCVDSGGQAT LKLEKKNITD LYNLKKAEKP FVFYLKETGS TATFESAAYP
     DCFICSSLGG PITLTKGSGK EKNTHFHLED TH
//
ID   F6SYA2_MONDO            Unreviewed;       157 AA.
AC   F6SYA2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017254};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017254, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000017254, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000017254}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000017254}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSMODT00000017573; ENSMODP00000017254; ENSMODG00000013803.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6SYA2; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   157 AA;  17763 MW;  582160D275D87618 CRC64;
     QFSLESIIHP SPRKIRDVHQ HVFVLQERTL IAVPEDENVT PIILETVSIL DESLEKGKGN
     ALYLGIGEQN PHLCLCCVAD EGQPTLKLEE KDIMDLPRTE NAVKSYVFYH NQSSNNISTF
     ESAAFPGWFI CSSEEQRKPI NITNDVGKNN ISFFLDF
//
ID   F6TDE0_MONDO            Unreviewed;       163 AA.
AC   F6TDE0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017250};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017250, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000017250, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000017250}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000017250}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSMODT00000017569; ENSMODP00000017250; ENSMODG00000013799.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6TDE0; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   163 AA;  18386 MW;  BC0C396061F3AA1E CRC64;
     LFPRNRQTPQ NIDKEKVPIG EIHDVQQQVW ILKGETLIAA PHEKGVNPVS LKVLPCRDDS
     LPKDKGDPIY LGINETDFCL CCEVSGGQPQ LQLVKEDIMK LYNNPEAVKA FVFYQNRTGS
     TSTLESAAYP DWFISSSDKD QPIILTHNTK SQYNTAFYLD ITT
//
ID   F6TE21_MONDO            Unreviewed;       154 AA.
AC   F6TE21;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017247};
DE   Flags: Fragment;
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSMODP00000017247};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017247, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000017247, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000017247}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000017247}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSMODT00000017566; ENSMODP00000017247; ENSMODG00000013795.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6TE21; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSMODP00000017247}.
SQ   SEQUENCE   154 AA;  17469 MW;  BE3E74A3DB824CC7 CRC64;
     SPNLYRPLCF RMKDTAMKVL YVQNNQLLAG KVRAGKNIDG EKISVVPNRS LDSKLIPIIL
     GFEGGTQCLS VGITQQPILQ IEHRNIMDLY QSKEESRSFT FYRWDAGITS RLESAAYPGW
     FLCTILEEDQ PITLTNHPED SHSVIADFYL EQCA
//
ID   F6TE57_MONDO            Unreviewed;       152 AA.
AC   F6TE57;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   06-JUL-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017242};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSMODP00000017242};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017242, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000017242, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000017242}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000017242}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_001363517.1; XM_001363480.3.
DR   STRING; 13616.ENSMODP00000017242; -.
DR   Ensembl; ENSMODT00000017561; ENSMODP00000017242; ENSMODG00000013791.
DR   GeneID; 100013210; -.
DR   KEGG; mdo:100013210; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6TE57; -.
DR   KO; K05488; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  17268 MW;  2AC35B1558946B24 CRC64;
     MCSLPMARYF VIKDAEQKPL YLRNDQLLVG DPNSEFYGAE KVCVLPNRSL DRNKFPIIMG
     IQDGSRCLAC VESGEGPLLQ LQDVNIEELY KGGEEATRFT FFRSSSGSTF QLESAAWPGW
     FLEAPTEPQE PVKLTKESEP SPRTQFYFEQ SR
//
ID   F6TEW6_MONDO            Unreviewed;       174 AA.
AC   F6TEW6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   06-JUL-2016, entry version 37.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000017238};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSMODP00000017238};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017238, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000017238, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000017238}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000017238}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_001376878.1; XM_001376841.3.
DR   STRING; 13616.ENSMODP00000017238; -.
DR   Ensembl; ENSMODT00000017557; ENSMODP00000017238; ENSMODG00000013787.
DR   GeneID; 100026175; -.
DR   KEGG; mdo:100026175; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6TEW6; -.
DR   KO; K05481; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    174       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003343379.
SQ   SEQUENCE   174 AA;  19957 MW;  2132DBB7CEC7B50F CRC64;
     MDLSVCPRSY LITLFLFLFH SETESFPFVK MSSKRQAYRI WDIYQKTFYL RNNQLVAGYL
     QGSNTNLEEK IDLVSIEPDS VLLGIHDGRL GLACVKTGGT PKLQLEAVNI TDLDKNQQES
     KRFTFIKSEN DSICRFESAA CPGWFLCTQT ESDRPVGLSN TQANTITRFY FQRE
//
ID   F6U119_HORSE            Unreviewed;       218 AA.
AC   F6U119;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000013315};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSECAP00000013315};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013315, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000013315, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013315,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000013315}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013315};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000013315}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_001496063.2; XM_001496013.3.
DR   STRING; 9796.ENSECAP00000013315; -.
DR   PaxDb; F6U119; -.
DR   Ensembl; ENSECAT00000016486; ENSECAP00000013315; ENSECAG00000015732.
DR   GeneID; 100052470; -.
DR   KEGG; ecb:100052470; -.
DR   CTD; 27178; -.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6U119; -.
DR   KO; K05485; -.
DR   OMA; RKHTEFS; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   218 AA;  24099 MW;  E0E85B25DF16128D CRC64;
     MSFLEENSGV KTDSEDWERD ESQSCSEDPA RSPLGPGLSL TSMSSAHSSP KVTAKAPEKF
     SIYDQDHKVL VLDCGILRAV PDRPYILPET FFVLASHLSS ACEEKGSPIL LAVSKGELCL
     CCEKDKGQSK PSLQLKKKKL TDLATEKEQA RQPFIFYRAE VGSKNTLESV THPGWFICTS
     CNSGEPVGMT DILGKREHTE FSFRRVHKAE MSPIEATE
//
ID   F6U6H2_ORNAN            Unreviewed;       160 AA.
AC   F6U6H2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   08-JUN-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000016720};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSOANP00000016720};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000016720, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000016720}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016720};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000016720}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9258.ENSOANP00000016720; -.
DR   Ensembl; ENSOANT00000016723; ENSOANP00000016720; ENSOANG00000010552.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6U6H2; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002279; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   160 AA;  18218 MW;  9B77A2B8ABB0A96A CRC64;
     TDAFRLTKMQ SKRPVYRIWD VSQKTFYLRN NQLVAGYLQA SNMALEEKID VVPISPFNNT
     MFMGIQGGNR CLACVKTGDQ PVLQLEEINI ADLAKAGDQA KRFAFIKSHP GPTFRFESAA
     YPGWFLCTSQ EDQPVGLTRR TSPWDHAQDP ITTDFYFEKD
//
ID   F6U6R5_ORNAN            Unreviewed;       152 AA.
AC   F6U6R5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 31.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000016719};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSOANP00000016719};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000016719, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000016719}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016719};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000016719}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_001521239.2; XM_001521189.3.
DR   STRING; 9258.ENSOANP00000016719; -.
DR   Ensembl; ENSOANT00000016722; ENSOANP00000016719; ENSOANG00000010551.
DR   GeneID; 100092682; -.
DR   KEGG; oaa:100092682; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6U6R5; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002279; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16868 MW;  2388F303D4348454 CRC64;
     MCSLPLARYY IIKNAEQKAL YLRNDQLLAG DPGTENGSPE RVCVLPNRAL DPSKFPIIIG
     IQGGSRCLAC AETGEEPKLQ LEDVTIEDLY KGGERATRFT FYRSSCGDAF RLEAAARPGW
     FLCTPPEPWQ PLALSSEAGA STRTQFYFEL SR
//
ID   F6U6S3_ORNAN            Unreviewed;       155 AA.
AC   F6U6S3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000016718};
GN   Name=LOC100092676 {ECO:0000313|Ensembl:ENSOANP00000016718};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000016718, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000016718}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016718};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000016718}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSOANT00000016721; ENSOANP00000016718; ENSOANG00000010550.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000002279; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  17358 MW;  7181144C5684CF03 CRC64;
     SNPKYAESAP NGTLCDTANK YWMLVDKTVV AVPKSSNTNP DIFTLMPNRD PTAVEKGKPV
     YIGIQNKDLC LCCEDSGGQP VLQVKDKKIM DLYHNGDKSN CFRFYQNKSG SDTHSFESVA
     HPGWFICTSP HTEEPVSLTD KRGETHFTDF CFELK
//
ID   F6U6T1_ORNAN            Unreviewed;       167 AA.
AC   F6U6T1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000016717};
GN   Name=LOC100092676 {ECO:0000313|Ensembl:ENSOANP00000016717};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000016717, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000016717}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016717};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000016717}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSOANT00000016720; ENSOANP00000016717; ENSOANG00000010550.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6U6T1; -.
DR   OMA; YAESAPN; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002279; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   167 AA;  18709 MW;  ABCB1F1FFF81E750 CRC64;
     QVQKSPLDTD SQGHKQYAES APNGTLCDTA NKYWMLVDKT VVAVPKSSNT NPDIFTLMPN
     RDPTAVEKGK PVYIGIQNKD LCLCCEDSGG QPVLQVKDKK IMDLYHNGDK SNCFRFYQNK
     SGSDTHSFES VAHPGWFICT SPHTEEPVSL TDKRGETHFT DFCFELK
//
ID   F6U6U0_ORNAN            Unreviewed;       209 AA.
AC   F6U6U0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   08-JUN-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000016716};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSOANP00000016716};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000016716, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000016716}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016716};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000016716}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSOANT00000016719; ENSOANP00000016716; ENSOANG00000010549.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6U6U0; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002279; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   209 AA;  22453 MW;  E5841A1BD26A4DDB CRC64;
     MFASLPNRSP GLCHAVPPLL WHIQEPTGGG LQEDTPNPSR TGLKTELGKM VLASAMCFRL
     TDAVLKAVYV QNDQLLAGTP PGGYGAQEAS SFSPGAEVSM VPNRYVDGNL SPVILGVEAG
     QRCLSCGTAE EPVLKLEAVD IMDLYHHGDP SNRFTFLRRR SGATSRFESA MFPGWFLCSP
     PGEDQPLSLS RQPPDASLGF IDFSLQLCS
//
ID   F6U6U9_ORNAN            Unreviewed;       161 AA.
AC   F6U6U9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000016715};
GN   Name=LOC100092655 {ECO:0000313|Ensembl:ENSOANP00000016715};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000016715, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000016715}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016715};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000016715}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSOANT00000016718; ENSOANP00000016715; ENSOANG00000010548.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6U6U9; -.
DR   OMA; CCEESEG; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002279; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   161 AA;  18091 MW;  7BB00A0FBEE44159 CRC64;
     SFPRCLCGTV FLNNTESAPS GTLCDTANKY WMLVDKTVIA VPRSSDTNPD IFTLMPNRLM
     DKGNAVYIGI QNKDLCLCCE DSGGQPMLQV KDKKIMDLYN NGDESNRFRF YQNKSGSDTH
     SFESVAHPGW FICTSPHTEE PVGLTDIRGE THFTDFCFEL K
//
ID   F6U6W7_ORNAN            Unreviewed;       136 AA.
AC   F6U6W7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000016713};
GN   Name=LOC100092652 {ECO:0000313|Ensembl:ENSOANP00000016713};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000016713, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000016713}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016713};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000016713}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSOANT00000016716; ENSOANP00000016713; ENSOANG00000010547.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6U6W7; -.
DR   OMA; CEGSADQ; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002279; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   136 AA;  15204 MW;  62DA4B465F106A9F CRC64;
     DTADKYWMLV DKTITAVPKS PNTKLSSFKL MPNRQLSSGE KKSPVYIGIE DGNLCLCCEG
     SADQPTLQVE EKDIQDLYNN GDKTMRFSFY QNTSGSNTFN FESAAHPGWF ICTSPHPQEP
     VGLTNKLGET FITDFH
//
ID   F6UHT8_MONDO            Unreviewed;       211 AA.
AC   F6UHT8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   06-JUL-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000038361};
GN   Name=LOC103101367 {ECO:0000313|Ensembl:ENSMODP00000038361};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000038361, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000038361, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000038361}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000038361}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_016289344.1; XM_016433858.1.
DR   STRING; 13616.ENSMODP00000038361; -.
DR   Ensembl; ENSMODT00000039961; ENSMODP00000038361; ENSMODG00000025565.
DR   GeneID; 103101367; -.
DR   KEGG; mdo:103101367; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; F6UHT8; -.
DR   OMA; CASEIDY; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000002280; Chromosome 4.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   211 AA;  24460 MW;  BCAFFE85017BAF06 CRC64;
     MATASDYSEA LCASEIDYDL DLHSIEIVDL EFKDDTLYLI AGEKAKQEFS KLKETKCTIL
     RNKKNRVLVL VEEKGKEKAV FEEIPDKEIP KNAPRTQFII QYYKETVPTG FVVAISVKTE
     KKIYTMSCKD KKLHFKEGEA PQKIEDKEKD VLFYEENIKG QDKRRFKSVL YPEYYLASKP
     EKKNFKLILK KGCQDKEGSA DFIVQTCSKK D
//
ID   F6VT34_CALJA            Unreviewed;       272 AA.
AC   F6VT34;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 32.
DE   SubName: Full=Interleukin-1 alpha proprotein {ECO:0000313|EMBL:JAB04921.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000030146};
GN   Name=IL1A {ECO:0000313|EMBL:JAB04921.1,
GN   ECO:0000313|Ensembl:ENSCJAP00000030146};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000030146, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000030146, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000030146}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:JAB04921.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Bladder {ECO:0000313|EMBL:JAB04921.1};
RX   PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen
RT   mRNA sequences.";
RL   Gigascience 3:14-14(2014).
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01139929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GAMT01006940; JAB04921.1; -; mRNA.
DR   RefSeq; XP_002757550.1; XM_002757504.3.
DR   STRING; 9483.ENSCJAP00000030146; -.
DR   Ensembl; ENSCJAT00000031857; ENSCJAP00000030146; ENSCJAG00000016368.
DR   GeneID; 100406401; -.
DR   KEGG; cjc:100406401; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   KO; K04383; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008225; Chromosome 14.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   272 AA;  31048 MW;  39CCE2D68D1B9A04 CRC64;
     MAKVPDLFED LKNCYSENEE YSSSIDHLSL NQKSFYDVNY GSHHEECMDQ SVSLSISETS
     KTSKLTFKES VVIVSTNGKV LKKRRLTLNH SITDDDLEGI ANDIEEEIIK PRSAPFSFLS
     NAKYNFNKTR KHQFILNVAL NHQSVIQTND QHLMTTALQN LDEAVKFDMD AYISSKDDDK
     DYVTLRISKT RLYVSAQDEN QPALLKEMPE IPKTITADET NLLFFWETQG TKSYFRSVAH
     PDLLIATMQD SLVCLARGPP FITDFQILEN QA
//
ID   F6VUJ0_MACMU            Unreviewed;       193 AA.
AC   F6VUJ0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000019986};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSMMUP00000019986};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000019986, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000019986, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000019986,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000019986}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000019986};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000019986}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9544.ENSMMUP00000019986; -.
DR   Ensembl; ENSMMUT00000021372; ENSMMUP00000019986; ENSMMUG00000015248.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; F6VUJ0; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000006718; Chromosome 14.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22306 MW;  7D82A40255829DB8 CRC64;
     MAAEPAEDNC INFVAMKFID STLYFIGELL KNLESDYFGK LESKLSIIRN LNDQVLFIDQ
     GNRPLFEDMT DSDCRDNAPR TIFIINMYKD SQPRGMAVAI SVKCEKISTL SCENRIISFK
     EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLY KLILKKKDEL
     GDRSIMFTVQ NED
//
ID   F6VYZ4_CALJA            Unreviewed;       155 AA.
AC   F6VYZ4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000025597};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSCJAP00000025597};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000025597, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000025597, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000025597}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000025597}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01155184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002757557.1; XM_002757511.2.
DR   STRING; 9483.ENSCJAP00000025597; -.
DR   Ensembl; ENSCJAT00000027053; ENSCJAP00000025597; ENSCJAG00000036307.
DR   GeneID; 100413967; -.
DR   KEGG; cjc:100413967; -.
DR   CTD; 26525; -.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6VYZ4; -.
DR   KO; K05483; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008225; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  16981 MW;  006D66B14E05FAE7 CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
     VQGGSQCLSC GAGQEPTLTL EPVNIMELYT GAKESKSFTF YRRELGLTSS FESAAYPGWF
     LCTMPEADQP VRLTQLLENA GWDAPITDFY FQQCD
//
ID   F6WV71_MACMU            Unreviewed;        78 AA.
AC   F6WV71;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   06-JUL-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000007792};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSMMUP00000007792};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000007792, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000007792, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007792,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000007792}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007792};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000007792}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSMMUT00000008290; ENSMMUP00000007792; ENSMMUG00000005922.
DR   Ensembl; ENSMMUT00000008291; ENSMMUP00000007793; ENSMMUG00000005922.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   78 AA;  8827 MW;  6FD035C915D3BE10 CRC64;
     MKLAALKESA RRPFIFYRAQ VGSRNMLESA AHPGWFICTS CNCNEPVGVT DKFENRKHIE
     FSFQPVCKAE MSPSEVSD
//
ID   F6X1Q9_XENTR            Unreviewed;       288 AA.
AC   F6X1Q9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000002737};
DE   Flags: Fragment;
GN   Name=il1b {ECO:0000313|Ensembl:ENSXETP00000002737};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000002737, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000002737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000002737}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXETP00000002737}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAMC01014111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8364.ENSXETP00000002737; -.
DR   PaxDb; F6X1Q9; -.
DR   Ensembl; ENSXETT00000002737; ENSXETP00000002737; ENSXETG00000001276.
DR   Xenbase; XB-GENE-481756; il1b.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; F6X1Q9; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-XTR-446652; Interleukin-1 signaling.
DR   Reactome; R-XTR-448706; Interleukin-1 processing.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0042119; P:neutrophil activation; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:1901222; P:regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:Ensembl.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Cytokine {ECO:0000256|RuleBase:RU003753};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        3    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSXETP00000002737}.
SQ   SEQUENCE   288 AA;  32172 MW;  508321971AE0C232 CRC64;
     KKMALVPDLS SIPMESCSGD DEMFYSDSPP GMKDSMKDDS QWHSHPGHCS QYNLDIHLQI
     TQAKGSLQSF KKAVILVVAV EKLKRGKETF FGDADLLGLL DSIFVEEEIA FSRAKETHAS
     ATTYRYQRAT NCRIKDASNK CFVLQRFHGN AQLVALQLQG ANIQREEKVS MAFYATQPLQ
     GGSKRPVALG LVGKNLYLSC IAAENDQGSP QLYLEEISNI KDVKGEDLNR FIFMKSQNGL
     SESTTHSFES ATFPGWYIST SQKENELVQM VHQKNQAAIK DFNIFPTV
//
ID   F6X5M2_HORSE            Unreviewed;       152 AA.
AC   F6X5M2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000019306};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSECAP00000019306};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019306, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000019306, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019306,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000019306}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019306};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000019306}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_014586529.1; XM_014731043.1.
DR   RefSeq; XP_014586530.1; XM_014731044.1.
DR   STRING; 9796.ENSECAP00000019306; -.
DR   PaxDb; F6X5M2; -.
DR   Ensembl; ENSECAT00000023321; ENSECAP00000019306; ENSECAG00000021901.
DR   GeneID; 100052532; -.
DR   KEGG; ecb:100052532; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6X5M2; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16912 MW;  E9857F7FACC25D09 CRC64;
     MCSLPMARYY IIKDADQKSL YLKAGQLLVG DPDSDNCCAE KICILPNRGL DRTKVPIFLG
     IQGGSRCLAC VETGDGPSLQ LEDVNIEDLY KGGEEATRFT FFQRSMGSAF RLEAAAWPGW
     FLCGPAEPQQ PVRLTKESEP SPCTEFYFEQ SR
//
ID   F6YXJ4_HORSE            Unreviewed;       149 AA.
AC   F6YXJ4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000014561};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSECAP00000014561};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014561, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000014561, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014561,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000014561}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014561};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000014561}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   PaxDb; F6YXJ4; -.
DR   Ensembl; ENSECAT00000017887; ENSECAP00000014561; ENSECAG00000016985.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F6YXJ4; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   149 AA;  16504 MW;  755E1D9705192564 CRC64;
     KPQTGKVSDL SQQVWILQGQ TLVTVPRSDR VAAVTVTVVP CKYPESLEQG KGIPIYLGIQ
     DPEMCLSCED VEGQPTLQLK EQKILELYNQ AEPVKPFLFY HVKTGRTSTF ESVAFPGWFI
     ASSERGQPIF LTSDQGAVHN TAFNIDFSA
//
ID   F7AXQ5_CALJA            Unreviewed;       168 AA.
AC   F7AXQ5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000025657};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSCJAP00000025657};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000025657, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000025657, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000025657}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000025657}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01155188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000027116; ENSCJAP00000025657; ENSCJAG00000013959.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F7AXQ5; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008225; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   168 AA;  18529 MW;  7935DC2045E3A0D7 CRC64;
     MRGTPGHLGD EGKVIQQAGA VGTGHVNDLN QQVWTLQGQT LVSVPRSSSV TPVIVTVVTC
     KFPEALEQGK GDPIYLGIRN PEMCLYCEEV GEQPTLLLKE QKIMDLYDQP KPMKPFLFYC
     LKTGRTSTLE SVAFPGWFIA SSNRDQPIFL TSELGTSHNT AFELDIKD
//
ID   F7BCR4_CHICK            Unreviewed;       316 AA.
AC   F7BCR4;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   08-JUN-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGALP00000000737};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSGALP00000000737};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000000737, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000000737, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000000737,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000000737}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000000737};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PDB:4X38}
RP   X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) OF 155-316.
RA   Yin H.S., Cheng W.T.;
RT   "Gallus interleukin-1 beta mutant - E118A.";
RL   Submitted (NOV-2014) to the PDB data bank.
RN   [4] {ECO:0000213|PDB:4X3A}
RP   X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 155-316.
RA   Yin H.S., Cheng W.T.;
RT   "gallus interleukin-1 beta mutant - R140A.";
RL   Submitted (NOV-2014) to the PDB data bank.
RN   [5] {ECO:0000213|PDB:4X39}
RP   X-RAY CRYSTALLOGRAPHY (1.61 ANGSTROMS) OF 155-316.
RA   Yin H.S., Cheng W.T.;
RT   "Gallus interleukin-1 beta mutant - T117A.";
RL   Submitted (NOV-2014) to the PDB data bank.
RN   [6] {ECO:0000213|PDB:4X37}
RP   X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 155-316.
RA   Yin H.S., Cheng W.T., Cheng T.;
RT   "Gallus interleukin-1 mutant - E118K.";
RL   Submitted (NOV-2014) to the PDB data bank.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGALP00000000737}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   PDB; 4X37; X-ray; 1.63 A; A=155-316.
DR   PDB; 4X38; X-ray; 2.12 A; A=155-316.
DR   PDB; 4X39; X-ray; 1.61 A; A=155-316.
DR   PDB; 4X3A; X-ray; 1.75 A; A=155-316.
DR   PDBsum; 4X37; -.
DR   PDBsum; 4X38; -.
DR   PDBsum; 4X39; -.
DR   PDBsum; 4X3A; -.
DR   STRING; 9031.ENSGALP00000000737; -.
DR   PaxDb; F7BCR4; -.
DR   Ensembl; ENSGALT00000000738; ENSGALP00000000737; ENSGALG00000000534.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   HOVERGEN; HBG007328; -.
DR   OMA; HAMSIIV; -.
DR   Reactome; R-GGA-446652; Interleukin-1 signaling.
DR   Reactome; R-GGA-448706; Interleukin-1 processing.
DR   Proteomes; UP000000539; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IDA:AgBase.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; ISS:AgBase.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0043400; P:cortisol secretion; IDA:AgBase.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:4X37, ECO:0000213|PDB:4X38,
KW   ECO:0000213|PDB:4X39, ECO:0000213|PDB:4X3A};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN       83    141       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   316 AA;  34721 MW;  5469A7F59F564F01 CRC64;
     MEIPHGSRFL PALLENASLS SGAQSAPKAA GGAQHRGLPS PSAFTLGTEM AFVPDLDVLE
     SSSLSEETFY GPSCLCLQKK PRLDSEHTTV DVQVTVRKGR GARSFRRAAV LVVAMTKLLR
     RPRSRDFADS DLSALLEEVF EPVTFQRLES SYAGAPAFRY TRSQSFDIFD INQKCFVLES
     PTQLVALHLQ GPSSSQKVRL NIALYRPRGP RGSAGTGQMP VALGIKGYKL YMSCVMSGTE
     PTLQLEEADV MRDIDSVELT RFIFYRLDSP TEGTTRFESA AFPGWFICTS LQPRQPVGIT
     NQPDQVNIAT YKLSGR
//
ID   F7BF20_ORNAN            Unreviewed;       202 AA.
AC   F7BF20;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   08-JUN-2016, entry version 31.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000022580};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSOANP00000022580};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000022580, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000022580}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022580};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000022580}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_001514335.3; XM_001514285.4.
DR   STRING; 9258.ENSOANP00000022580; -.
DR   Ensembl; ENSOANT00000022584; ENSOANP00000022580; ENSOANG00000014328.
DR   GeneID; 100083773; -.
DR   KEGG; oaa:100083773; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; F7BF20; -.
DR   KO; K05482; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000002279; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   202 AA;  22957 MW;  2ED81E5F180924BF CRC64;
     MAAGCTSVLE PDMTLTLIAN LDGDTFYFRD EDEDGFESDA FMKHGNPKFQ VFQDSSTKVL
     VMKQDSCTPR FEAMSEQEIK DNAPQTKFII QFYKNTKPGC YPVTISVKSG DRTFHLSCQG
     NILHFEKGEV PQKIDEDQSD IIFFQKGIVG FKDRYQFQPS SCPGSYLACE KKQNDSYFTM
     ILKKVSGDEN DSTHMTLKPF PQ
//
ID   F7BXK7_CALJA            Unreviewed;       121 AA.
AC   F7BXK7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000025636};
DE   Flags: Fragment;
GN   Name=IL36B {ECO:0000313|Ensembl:ENSCJAP00000025636};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000025636, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000025636, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000025636}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000025636}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01155185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9483.ENSCJAP00000025636; -.
DR   Ensembl; ENSCJAT00000027094; ENSCJAP00000025636; ENSCJAG00000013951.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F7BXK7; -.
DR   OMA; KEINIMD; -.
DR   OrthoDB; EOG7034JW; -.
DR   Proteomes; UP000008225; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSCJAP00000025636}.
SQ   SEQUENCE   121 AA;  13817 MW;  E292892D9958D136 CRC64;
     VFSVTLDLIA CRDTEFGDEK KGNVVYPGIK GKEFCVFCAE IQGKLILQLN EKNIMDLYME
     NKAEKPFLFF HNKEGSTSLF QLVFYPGWFI APSSTSRQPT ILTQERGKTN NTNFCLYSVN
     L
//
ID   F7C2V6_HORSE            Unreviewed;       155 AA.
AC   F7C2V6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000017907};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSECAP00000017907};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017907, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000017907, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017907,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000017907}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017907};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000017907}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_001496214.1; XM_001496164.2.
DR   PaxDb; F7C2V6; -.
DR   Ensembl; ENSECAT00000021720; ENSECAP00000017907; ENSECAG00000020486.
DR   GeneID; 100065154; -.
DR   KEGG; ecb:100065154; -.
DR   CTD; 26525; -.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F7C2V6; -.
DR   KO; K05483; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  17106 MW;  282B68CA7A0CBF32 CRC64;
     MVLSGALCFR MKDAALKVLY LHDNQLLAGG LHTGKVMKGE EISVVPNRFL DAKLSPVILG
     VQGGSQCLSC GTEQEPTLKL EPVNIMELYL GAKEYKSFTF YRRDTGLTSS FESAAYPGWF
     LCTVPEADQP LRLTQLPDDA SGDDPITDFY FQQCD
//
ID   F7C3T8_HORSE            Unreviewed;       268 AA.
AC   F7C3T8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 30.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|Ensembl:ENSECAP00000021137};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSECAP00000021137};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021137, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000021137, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021137,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000021137}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021137};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000021137}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9796.ENSECAP00000021137; -.
DR   PaxDb; F7C3T8; -.
DR   Ensembl; ENSECAT00000025409; ENSECAP00000021137; ENSECAG00000023727.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30580 MW;  F6EC94128D0DE5CD CRC64;
     MAKVPDLFED LKNCYSENED YSSEIDHLSL TQKSFYDASY DPLPEDCMDT FMSLSTSETS
     KTSKLNFKES VVLVAANGKT LKKRRLSLNQ FITNDDLEAI ANDPEEGIIK PRSVHYNFQS
     NTKYNFMRIV NHQCTLNDAL NQSVIRDTSG QYLATAALFS LPVKFDMGAY TSEEDSQLPV
     TLRISKTRLF VSAQNEDEPV LLKEMPDTPK TIKDETNLLF FWERHGSKNY FKSVAHPKLF
     IATKQGKLVH MARGQPSITD FQILDNQF
//
ID   F7CCC7_CALJA            Unreviewed;       152 AA.
AC   F7CCC7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000025621};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSCJAP00000025621};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000025621, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000025621, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000025621}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000025621}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01155184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002757560.1; XM_002757514.2.
DR   STRING; 9483.ENSCJAP00000025621; -.
DR   Ensembl; ENSCJAT00000027077; ENSCJAP00000025621; ENSCJAG00000013941.
DR   Ensembl; ENSCJAT00000027090; ENSCJAP00000025632; ENSCJAG00000013941.
DR   GeneID; 100385278; -.
DR   KEGG; cjc:100385278; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008225; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16994 MW;  4022310897F19386 CRC64;
     MCSLPMARYY TIKYADQKVL YTRDSQLLVG DPVADNCCAE KICILPNRGL DRTKVPIFLG
     IQGGSRCLAC VETGEEPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAAWPGW
     FLCGPAESQQ PVQLTKESEP SARTEFYFEQ SR
//
ID   F7CCI7_HORSE            Unreviewed;       268 AA.
AC   F7CCI7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000000159};
GN   Name=LOC100052414 {ECO:0000313|Ensembl:ENSECAP00000000159};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000000159, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000000159, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000159,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000000159}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000159};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000000159}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_001495976.2; XM_001495926.4.
DR   UniGene; Eca.13475; -.
DR   STRING; 9796.ENSECAP00000000159; -.
DR   PaxDb; F7CCI7; -.
DR   Ensembl; ENSECAT00000000217; ENSECAP00000000159; ENSECAG00000000168.
DR   GeneID; 100052414; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; F7CCI7; -.
DR   OMA; HAMSIIV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30185 MW;  EF365135E69C8C92 CRC64;
     MAAVPDTSDM MTYCSGNEND LFFEEDGPKQ MKGSFQDLDL SSMGDGGIQL QISHHLYNKT
     FKHAMSIIVA VEKLKKIPVP CSQAFQDDDL RSLFSVIFEE EPIICDNWDE GYVCDAAMHS
     VNCRLRDIYH KSLVLSGACE LQAVHLNGEN TNQQVVFCMS FVQGEEETDK IPVALGLKGK
     NLYLSCGTKD GKPILQLETV DPNTYPKRKM EKRFVFNKME IKGNVEFESA MYPNWYISTS
     QAEKKPVFLG NTRGGRDITD FIMEITSA
//
ID   F7CCX0_CALJA            Unreviewed;       180 AA.
AC   F7CCX0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000025611};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSCJAP00000025611};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000025611, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000025611, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000025611}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000025611}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01155179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01155180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9483.ENSCJAP00000025611; -.
DR   Ensembl; ENSCJAT00000027067; ENSCJAP00000025611; ENSCJAG00000013930.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F7CCX0; -.
DR   OMA; FESAACR; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008225; Chromosome 14.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    180       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003350200.
SQ   SEQUENCE   180 AA;  20232 MW;  D126D38669B4B2EF CRC64;
     MEICRGLRSH LIPLLLFLFH SETVSHPCGK RPCKMQAFRF WGNRGDRKTP RVSSLLLPPL
     LLTPPSLCSS SEKIDVVHIE PHSLFLGIHG GKMCLSCVKT GDETRLQLEA VDITDLSKNK
     KQDERFTFIR SDSGPTTSFE SAACRGWFLC TAMDADQPVS LTNTPNKGIM VTKFYFQEDE
//
ID   F7CKM2_HORSE            Unreviewed;       151 AA.
AC   F7CKM2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000017550};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSECAP00000017550};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017550, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000017550, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017550,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000017550}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017550};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000017550}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   PaxDb; F7CKM2; -.
DR   Ensembl; ENSECAT00000021318; ENSECAP00000017550; ENSECAG00000020092.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F7CKM2; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   151 AA;  17118 MW;  7229979629D48376 CRC64;
     QIPDYFRVRD PLQMVWVVEG DSLMAVPFNN NVKPVTLDII SCTDEKLHDE AKGNLVYLGI
     KGTNHSLFCA KIQGQPTLQI KEKNVMDLHH MNEGQKPFLF FRIIEGTTSA FQSFSCPGWF
     IATSSTARQP ITLTKERGGT ENTNFYLEPE H
//
ID   F7DJL0_MONDO            Unreviewed;       207 AA.
AC   F7DJL0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   06-JUL-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000034135};
GN   Name=LOC103102395 {ECO:0000313|Ensembl:ENSMODP00000034135};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000034135, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000034135, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000034135}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000034135}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_007494889.1; XM_007494827.2.
DR   STRING; 13616.ENSMODP00000034135; -.
DR   Ensembl; ENSMODT00000035721; ENSMODP00000034135; ENSMODG00000014381.
DR   GeneID; 103102395; -.
DR   KEGG; mdo:103102395; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; F7DJL0; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000002280; Chromosome 4.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   207 AA;  23779 MW;  2BF0318F52130F40 CRC64;
     MALERHCDRD DNAINLIAVE LREGTLYFKA EDDDDLESDV FTKCEDSKDS VLRNQKHQVL
     MMTSEDTAVF ETMTQVEIEG NAPQTKFVIQ TYKESTPRGY AVAIMVRNKN ETYILSCQGK
     ALKFQKGTFP PCIDSDVSDL IFYQKKVKGH EKMQFESSLY QKCFLACEKE SKSGHFKLVL
     KEVCQEEDGV TLFTVKNFLE KKDIKPL
//
ID   F7E955_MACMU            Unreviewed;       155 AA.
AC   F7E955;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 39.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000023946};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSMMUP00000023946};
GN   ORFNames=EGK_05695 {ECO:0000313|EMBL:EHH22434.1};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000023946, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000023946, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000023946,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|EMBL:EHH22434.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CR-5 {ECO:0000313|EMBL:EHH22434.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMMUP00000023946}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000023946};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CM001265; EHH22434.1; -; Genomic_DNA.
DR   RefSeq; XP_001093641.1; XM_001093641.3.
DR   STRING; 9544.ENSMMUP00000023946; -.
DR   Ensembl; ENSMMUT00000025593; ENSMMUP00000023946; ENSMMUG00000018205.
DR   GeneID; 705268; -.
DR   KEGG; mcc:705268; -.
DR   CTD; 26525; -.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   KO; K05483; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  16907 MW;  CF46CCCE2617C407 CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPSRWL DASLSPVILG
     VQGGSQCLSC GAGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF
     LCTVPEADQP VRLTQLPDNA GWNAPITDFY FQQCD
//
ID   F7E966_MACMU            Unreviewed;       151 AA.
AC   F7E966;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000023944};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSMMUP00000023944};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000023944, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000023944, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000023944,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000023944}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000023944};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000023944}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSMMUT00000025591; ENSMMUP00000023944; ENSMMUG00000018203.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   151 AA;  16528 MW;  CF873345A545C556 CRC64;
     MCSLPMARYY ISFLPEPLPA KSLQLGAPLS LASSLSSLLE KICILPNRGL DRTKVPIFLG
     IQGGSCCLAC VETGEGPSVQ LEDVNIEELY KGGEEATRFT FFQSSSSAFR LEAAARPGWF
     LCGPAEPQQP VQLTKESEPS ARTEFYFEQS R
//
ID   F7E972_MACMU            Unreviewed;       151 AA.
AC   F7E972;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000023943};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSMMUP00000023943};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000023943, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000023943, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000023943,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000023943}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000023943};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000023943}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9544.ENSMMUP00000036116; -.
DR   Ensembl; ENSMMUT00000025590; ENSMMUP00000023943; ENSMMUG00000018203.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   151 AA;  16762 MW;  FFCA5A0CB5182BC8 CRC64;
     MCSLPMARYY IIKYADQKAL YMRDGQLLVG DPVADNCCAE KICILPNRGL DRTKVPIFLG
     IQGGSCCLAC VETGEGPSVQ LEDVNIEELY KGGEEATRFT FFQSSSSAFR LEAAARPGWF
     LCGPAEPQQP VQLTKESEPS ARTEFYFEQS R
//
ID   F7FNC4_RAT              Unreviewed;       164 AA.
AC   F7FNC4;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   08-JUN-2016, entry version 9.
DE   SubName: Full=Protein Il36g {ECO:0000313|Ensembl:ENSRNOP00000007512};
DE   SubName: Full=Similar to IL-1F9 (Predicted) {ECO:0000313|EMBL:EDL93671.1};
GN   Name=Il36g {ECO:0000313|Ensembl:ENSRNOP00000007512,
GN   ECO:0000313|RGD:1563019};
GN   Synonyms=RGD1563019_predicted {ECO:0000313|EMBL:EDL93671.1};
GN   ORFNames=rCG_45436 {ECO:0000313|EMBL:EDL93671.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000007512, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000007512, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007512,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|EMBL:EDL93671.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL93671.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [3] {ECO:0000313|EMBL:EDL93671.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL93671.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA   Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA   Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSRNOP00000007512}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007512};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AABR07051207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH474001; EDL93671.1; -; Genomic_DNA.
DR   RefSeq; XP_008759827.1; XM_008761605.1.
DR   UniGene; Rn.152030; -.
DR   Ensembl; ENSRNOT00000007512; ENSRNOP00000007512; ENSRNOG00000005701.
DR   GeneID; 499744; -.
DR   CTD; 56300; -.
DR   RGD; 1563019; Il36g.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052100; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-RNO-449147; Signaling by Interleukins.
DR   Proteomes; UP000002494; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   164 AA;  18301 MW;  B241F339EF542D14 CRC64;
     MSSKYPHSPC TASGKETPDL GQVSDVDQQV WIFRDQALVT VPRSHTVTPV TVTVLPCKYP
     ESLEQGKGTP IYLGIQNPDK CLFCKEVNGH PTLLLKEEKI LNLYHHPEPM KPFLFYHTLT
     GATSTFESVV FPGSFIASSK IGKPIFLTSK KGEHYNIHFS LDII
//
ID   F7G8J2_MACMU            Unreviewed;       268 AA.
AC   F7G8J2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 35.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|Ensembl:ENSMMUP00000026007};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSMMUP00000026007};
GN   ORFNames=EGK_05690 {ECO:0000313|EMBL:EHH22429.1};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000026007, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000026007, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026007,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|EMBL:EHH22429.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CR-5 {ECO:0000313|EMBL:EHH22429.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMMUP00000026007}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026007};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CM001265; EHH22429.1; -; Genomic_DNA.
DR   STRING; 9544.ENSMMUP00000026007; -.
DR   Ensembl; ENSMMUT00000027799; ENSMMUP00000026007; ENSMMUG00000019778.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30452 MW;  6E7A266E3E2C05A1 CRC64;
     MAEVPELASE MMAYYSGNED DLFFDVDGPK QMKCSFQDLD LCPLDGGIQL QISHEHYNEG
     FRQAVSVVVA MEKLRKMLVP CPQIFQDNDL STLIPFIFEE EPVFLDTRNN DACVHDAPVR
     SLHCTLRDAQ LKSLVMSGPY ELKALHLQGQ DLEQQVVFSM SFVQGEESND KIPVALGLKA
     KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST
     SQAENMPVFL GGTRGGQDIT DFTMQFVS
//
ID   F7G8K0_MACMU            Unreviewed;       271 AA.
AC   F7G8K0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 32.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|Ensembl:ENSMMUP00000026006};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSMMUP00000026006};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000026006, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000026006, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026006,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000026006}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026006};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000026006}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_014968618.1; XM_015113132.1.
DR   RefSeq; XP_014968619.1; XM_015113133.1.
DR   UniGene; Mmu.3361; -.
DR   STRING; 9544.ENSMMUP00000026006; -.
DR   Ensembl; ENSMMUT00000027798; ENSMMUP00000026006; ENSMMUG00000019777.
DR   GeneID; 700193; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   271 AA;  30702 MW;  0526AD7C40455290 CRC64;
     MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYDVSY GPLHEGCMDQ SVSLSISEIS
     KTSKLTFKQS MVVVSTNGKV LKKRRLSLSQ SITDNNLEAI ANDSEEEIIK PRSAPFSFLS
     NMTYHFIRII KHEFILNDTL NQTIIRANDQ YLTAAAIHNL DEAVKFDMGA YTSSKDDTKV
     PVILRISKTQ LYVSAQDEDQ PVLLKEMPEI PKTITGSETN FLFFWETHGT KNYFISVAHP
     NLFIATKHDN WVCLAKGLPS ITDFQILENQ A
//
ID   F7H3K5_MACMU            Unreviewed;       168 AA.
AC   F7H3K5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000036120};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSMMUP00000036120};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000036120, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000036120, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036120,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000036120}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036120};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000036120}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_001090647.1; XM_001090647.3.
DR   Ensembl; ENSMMUT00000043106; ENSMMUP00000036120; ENSMMUG00000000989.
DR   GeneID; 700822; -.
DR   KEGG; mcc:700822; -.
DR   CTD; 56300; -.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F7H3K5; -.
DR   KO; K05487; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   ExpressionAtlas; F7H3K5; baseline.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   168 AA;  18567 MW;  3F2AA8E87BD33BA7 CRC64;
     MRGTPGNPAG GGRVVYQSMR TPITGTINDL NQQVWTLQGQ ILVAVPRSDS VTPVTVAVIT
     CKYPEALDQS RGDPIYLGIR NPEMCLCCEE VGGQPTLQLK EQKIMDLYGQ PEPVKPFLFY
     RVKTGRTSTL ESVAFPNWFI ASSTRDQPII LTSELGKSYN TAFELNIK
//
ID   F7H3R1_MACMU            Unreviewed;       163 AA.
AC   F7H3R1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000036116};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSMMUP00000036116};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000036116, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000036116, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036116,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000036116}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036116};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000036116}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9544.ENSMMUP00000036116; -.
DR   Ensembl; ENSMMUT00000043102; ENSMMUP00000036116; ENSMMUG00000018203.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F7H3R1; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   163 AA;  17504 MW;  3C8A83F7820B8C68 CRC64;
     MCSLPMARYY IIKYADQKAL YMRDGQLLVG DPVADNCCAE KICILPNRGL DRTKVPIFLG
     IQGGSCCLAC VETGEGPSVQ LEDVNIEELY KGGEEATRFT FFQSSSAPPS GSRLLPGLAG
     SCVARQSPSS QYSSPRRVSP RPVLSSTLNR AGRETGGCVS AWC
//
ID   F7HP64_MACMU            Unreviewed;       178 AA.
AC   F7HP64;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-JUN-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000017085};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSMMUP00000017085};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000017085, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000017085, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000017085,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000017085}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000017085};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000017085}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9544.ENSMMUP00000017085; -.
DR   Ensembl; ENSMMUT00000018251; ENSMMUP00000017085; ENSMMUG00000013014.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F7HP64; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000006718; Chromosome 13.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   178 AA;  19742 MW;  7A0FAAEC7B4F7AE9 CRC64;
     LTADLYEEGG GGRGEGEDSA DKRTVGRPSG RKPSKMQAFR IWDVNQKTFY LRNNQLVAGY
     LQGPNVNLEE KIDVVPIEPH ALFLGIHGGK MCLSCVKSGD ETRLQLEAVN ITDLSKNRKQ
     DKRFAFVRSD SGPTTSFESA ACPGWFLCTA MEADQPVSLT NMPDKGVMVT KFYFQEDE
//
ID   F7I5B4_CALJA            Unreviewed;       219 AA.
AC   F7I5B4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000031896};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSCJAP00000031896};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000031896, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000031896, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000031896}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000031896}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01027772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9483.ENSCJAP00000031896; -.
DR   Ensembl; ENSCJAT00000033713; ENSCJAP00000031896; ENSCJAG00000017305.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; F7I5B4; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008225; Chromosome 19.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   219 AA;  24753 MW;  8FBA8039F4832E67 CRC64;
     MSFVEENSGV KMGSEDLERD EPQCLSEAQL EAPLEPDPSL PFMSFVHSTR PSKVEELKPE
     KFSIHDQDHK VLVLDSGNII AVPDKSYICP EIFFMLPTSL SSASAEKGSP IHLGVSKEEF
     CYCDKDKDQS CPSLQLKKKK LMKLADQKES ARRPFIFHRT QVGSQNLLES MVHPRWFVCT
     SCNCNEPVGV TDKHEHKKHT EFLFHPVCKA EMSPSEVSD
//
ID   F7I7M1_CALJA            Unreviewed;       216 AA.
AC   F7I7M1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000031888};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSCJAP00000031888};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000031888, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000031888, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000031888}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000031888}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01027772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000033705; ENSCJAP00000031888; ENSCJAG00000017305.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000008225; Chromosome 19.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   216 AA;  24183 MW;  B6BB4FB2B55FA2EA CRC64;
     MSFVEENSGV KMGSEDLERD EPQCLSEGAS GAPLEPDPSL PFMSFVHSSP KLKNLPEKFS
     IHDQDHKVLV LDSGNIIAVP DKSYICPDIF FMLPTSLSSA SAEKGSPIHL GVSKEEFCYC
     DKDKDQSCPS LQLKKKKLMK LADQKESARR PFIFHRTQVG SQNLLESMVH PRWFVCTSCN
     CNEPVGVTDK HEHKKHTEFL FHPVCKAEMS PSEVSD
//
ID   F7I7N0_CALJA            Unreviewed;       195 AA.
AC   F7I7N0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 21.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000031882};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSCJAP00000031882};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000031882, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000031882, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000031882}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000031882}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01027772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000033699; ENSCJAP00000031882; ENSCJAG00000017305.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000008225; Chromosome 19.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   195 AA;  22038 MW;  69AB20AD5DC93C82 CRC64;
     MSFVEENSGV KMGSEDLERD EPQCLSEGPK LKNLNLKFSI HDQDHKVLVL DSGNIIAVPD
     KSYICPEIFF MLPTSLSSAS AEKGSPIHLG VSKEEFVYCD KDKDQSCPSL QLKKKKLMKL
     ADQKESARRP FIFHRTQVGS QNLLESMVHP RWFVCTSCNC NEPVGVTDKH EHKKHTEFLF
     HPVCKAEMSP SEVSD
//
ID   F7I9Y3_CALJA            Unreviewed;       177 AA.
AC   F7I9Y3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000031878};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSCJAP00000031878};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000031878, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000031878, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000031878}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000031878}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01027772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000033695; ENSCJAP00000031878; ENSCJAG00000017305.
DR   GeneTree; ENSGT00530000062899; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   Proteomes; UP000008225; Chromosome 19.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   177 AA;  19962 MW;  046781E7D63154B3 CRC64;
     MSFVEENSGV KMGSEDLERD EPQCLSEDPV GSPLEPDPSL PFMSFVHSKI FFMLPTSLSS
     ASAEKGSPIH LGVSKEEFVY CDKDKDQSCP SLQLKKKKLM KLADQKESAR RPFIFHRTQV
     GSQNLLESMV HPRWFVCTSC NCNEPVGVTD KHEHKKHTEF LFHPVCKAEM SPSEVSD
//
ID   F7ICA8_CALJA            Unreviewed;       156 AA.
AC   F7ICA8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000031855};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSCJAP00000031855};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000031855, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000031855, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000031855}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000031855}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01027772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9483.ENSCJAP00000031896; -.
DR   Ensembl; ENSCJAT00000033672; ENSCJAP00000031855; ENSCJAG00000017305.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000008225; Chromosome 19.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   156 AA;  17725 MW;  D57E61E1F1159F5D CRC64;
     MSFVEENSGV KMGSEDLERD EPQCLSEEIF FMLPTSLSSA SAEKGSPIHL GVSKEEFVYC
     DKDKDQSCPS LQLKKKKLMK LADQKESARR PFIFHRTQVG SQNLLESMVH PRWFVCTSCN
     CNEPVGVTDK HEHKKHTEFL FHPVCKAEMS PSEVSD
//
ID   F7ICB1_CALJA            Unreviewed;       188 AA.
AC   F7ICB1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000031852};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSCJAP00000031852};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000031852, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000031852, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000031852}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000031852}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACFV01027772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9483.ENSCJAP00000031896; -.
DR   Ensembl; ENSCJAT00000033669; ENSCJAP00000031852; ENSCJAG00000017305.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; RKHTEFS; -.
DR   Proteomes; UP000008225; Chromosome 19.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   188 AA;  21452 MW;  1DF73840FACE49C2 CRC64;
     MSGCDRIQTE IKIRFKKHLR GPKLKNLNLK FSIHDQDHKV LVLDSGNIIA VPDKSYICPE
     IFFMLPTSLS SASAEKGSPI HLGVSKEEFV YCDKDKDQSC PSLQLKKKKL MKLADQKESA
     RRPFIFHRTQ VGSQNLLESM VHPRWFVCTS CNCNEPVGVT DKHEHKKHTE FLFHPVCKAE
     MSPSEVSD
//
ID   F7IHM7_CALJA            Unreviewed;       193 AA.
AC   F7IHM7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   11-MAY-2016, entry version 32.
DE   SubName: Full=Interleukin-18 isoform 1 proprotein {ECO:0000313|EMBL:JAB05421.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000022914};
GN   Name=IL18 {ECO:0000313|EMBL:JAB05421.1,
GN   ECO:0000313|Ensembl:ENSCJAP00000022914};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000022914, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000022914, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000022914}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:JAB05421.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Bladder {ECO:0000313|EMBL:JAB05421.1}, and
RC   Cerebellum {ECO:0000313|EMBL:JAB46841.1};
RX   PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen
RT   mRNA sequences.";
RL   Gigascience 3:14-14(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; ACFV01120582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GAMT01006440; JAB05421.1; -; mRNA.
DR   EMBL; GAMP01005914; JAB46841.1; -; mRNA.
DR   RefSeq; XP_002754458.1; XM_002754412.3.
DR   RefSeq; XP_009005051.1; XM_009006803.1.
DR   RefSeq; XP_009005052.1; XM_009006804.1.
DR   STRING; 9483.ENSCJAP00000022914; -.
DR   Ensembl; ENSCJAT00000024244; ENSCJAP00000022914; ENSCJAG00000012499.
DR   GeneID; 100396804; -.
DR   KEGG; cjc:100396804; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000008225; Chromosome 11.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  21997 MW;  3998F7D589718475 CRC64;
     MAAEPVEDNC INFVEMKFTG DALYFRAEDD ENLETDHFAK LKSKLAIIRN VDDQVLFLGQ
     GNHPLFEDMT DSDCEANASR TIFIIYMYKD SEPRGLAVTI SVKCGKISTL SCENKIISFK
     EISPPDNITD TKSDIIFFQR SVPGHDDKMQ FESSSYEGYF LACKKEEDLF KLILKRKDEL
     GDKSLLFTVQ SKD
//
ID   G1LBK5_AILME            Unreviewed;       192 AA.
AC   G1LBK5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 30.
DE   SubName: Full=Interleukin 18 {ECO:0000313|EMBL:AEA11028.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000004279};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSAMEP00000004279};
GN   Synonyms=IL-18 {ECO:0000313|EMBL:AGV22105.1};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000004279, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000004279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|EMBL:AEA11028.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Yan Y., Zhang Y.Z., Tan X.M.;
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSAMEP00000004279}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:AGV22105.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:AGV22105.1};
RX   PubMed=25501180; DOI=10.4238/2014.November19.1;
RA   Yan Y., Wang Q., Niu L.L., Deng J.B., Yu J.Q., Zhang J X Wang Y.Z.,
RA   Yin M.M., Tan X.M.;
RT   "Molecular cloning, characterization, and ioactivity analysis of
RT   interleukin 18 in giant panda (Ailuropoda melanoleuca).";
RL   Genet. Mol. Res. 13:9687-9700(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
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CC   -----------------------------------------------------------------------
DR   EMBL; ACTA01192010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; HQ874655; AEA11028.1; -; mRNA.
DR   EMBL; KF512471; AGV22105.1; -; Genomic_DNA.
DR   RefSeq; NP_001291772.1; NM_001304843.1.
DR   RefSeq; XP_002921155.1; XM_002921109.2.
DR   RefSeq; XP_011225620.1; XM_011227318.1.
DR   STRING; 9646.ENSAMEP00000004279; -.
DR   Ensembl; ENSAMET00000004450; ENSAMEP00000004279; ENSAMEG00000004043.
DR   GeneID; 100484109; -.
DR   KEGG; aml:100484109; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   192 AA;  21950 MW;  F10B87DC23732B87 CRC64;
     MAANTEDNCI NFVEMKLIDN TLYFIAENDD SLESDYFGKL EPKLSIIRNL NDQVLFVNQG
     NQPVFEDMPD SDCTDNAPHT VFIIYMYKDS LTRGLAVTIS VKCKKMSTLS CKNKTISFKE
     MCPPNSINDE GNDIIFFQRS VPGHDDKIQF ESSLYQGYFL ACQKEKDLFK LILKKKDESG
     DKSIMFTVQN KS
//
ID   G1LW10_AILME            Unreviewed;       176 AA.
AC   G1LW10;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   08-JUN-2016, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000011261};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSAMEP00000011261};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011261, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000011261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000011261}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000011261}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACTA01100604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002926374.1; XM_002926328.2.
DR   STRING; 9646.ENSAMEP00000011261; -.
DR   Ensembl; ENSAMET00000011740; ENSAMEP00000011261; ENSAMEG00000010701.
DR   GeneID; 100480371; -.
DR   KEGG; aml:100480371; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1LW10; -.
DR   KO; K05481; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    176       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003415301.
SQ   SEQUENCE   176 AA;  20161 MW;  B9BAE1902DC0C679 CRC64;
     MEACRCPLSY LISFLLFLFH SETACHPLRK RPCRMQVFRI WDINQKTFYL RNNQLVAGYL
     QGSNTKLEEK LDVVPIEPHA VFLGIHGGKL CLSCVKSGDE TRLQLEAVNI TDLSRNKDQD
     KRFTFILSDS GPTTSFESAA CPGWFLCTAL EADRPVSLTN TPKEDWMVTK FYFQKD
//
ID   G1LW13_AILME            Unreviewed;       151 AA.
AC   G1LW13;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000011264};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSAMEP00000011264};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011264, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000011264}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000011264}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000011264}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACTA01100604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9646.ENSAMEP00000011264; -.
DR   Ensembl; ENSAMET00000011743; ENSAMEP00000011264; ENSAMEG00000010720.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1LW13; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   151 AA;  16800 MW;  ECC6B9805A802363 CRC64;
     MCSLPMARYY TIKDADQKAL YSRGDRLLVG DPNVDNGCAE KICILPNRGL DRTKVPIFLG
     IQGGSRCLAC VETGEGPTLQ LEDVNIEDLY KGGEEATRFT FFQRSLGSAF RLEAAAWPGW
     FLCGPAEPQQ PVQLVKESEP LARTEFYFEQ S
//
ID   G1LW16_AILME            Unreviewed;       156 AA.
AC   G1LW16;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000011267};
DE   Flags: Fragment;
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSAMEP00000011267};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011267, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000011267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000011267}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000011267}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACTA01108604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMET00000011746; ENSAMEP00000011267; ENSAMEG00000010722.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1LW16; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSAMEP00000011267}.
SQ   SEQUENCE   156 AA;  17119 MW;  B9CFCE0562DBA85D CRC64;
     KMVLSGALCF RMKDAALKVL YLQDNQLLAG GLHAGKVIKG EEISVVPNRS LDAKLSPVIL
     GVQGGSQCLS CGTGQEPTLK LEPVNIMELY LSANESKSFT FYRRDTGLTS SFESAAYPGW
     FLCTVLEADQ PLRLTQLSED GSWDNPITDF YFQQCD
//
ID   G1LW19_AILME            Unreviewed;       154 AA.
AC   G1LW19;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000011270};
DE   Flags: Fragment;
GN   Name=IL36B {ECO:0000313|Ensembl:ENSAMEP00000011270};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011270, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000011270}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000011270}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000011270}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACTA01108604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMET00000011749; ENSAMEP00000011270; ENSAMEG00000010725.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1LW19; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSAMEP00000011270}.
SQ   SEQUENCE   154 AA;  17434 MW;  CFF1F4F91320CF50 CRC64;
     SAVDFPRIFG VYDSQQMVWI LKENSLIATP FSRNVIPVSL DLITCTDKAF HDAGKGNPVY
     LGIKGNHLCL FCAEIQGQPT LQLKEKKIMD MSNEKKAQKP FLFFHSREGS TSTFQSVSYP
     DWFIATSKMA GQPVILTKER GKNYTTNFYL EPED
//
ID   G1LW25_AILME            Unreviewed;       153 AA.
AC   G1LW25;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000011276};
DE   Flags: Fragment;
GN   Name=IL36G {ECO:0000313|Ensembl:ENSAMEP00000011276};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011276, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000011276}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000011276}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000011276}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACTA01108604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMET00000011756; ENSAMEP00000011276; ENSAMEG00000010727.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1LW25; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSAMEP00000011276}.
SQ   SEQUENCE   153 AA;  16875 MW;  89B0F02B8D71D5D1 CRC64;
     TAVNKPHTGE VSDLNQQVWV LQGQTIVTVP RSNNVTPVTV TVVPCKYPEL LGQGRGVPIY
     LGIENPEMCL SCEDIEGQPT LQLKEEEILD LYNEVEPVEP FLFYHSKNGS TSTFESVAFP
     GWFVAASDRG HPIFLTSHLG GTYNVNFILN INA
//
ID   G1LW44_AILME            Unreviewed;       269 AA.
AC   G1LW44;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 36.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000011295};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSAMEP00000011295};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011295, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000011295}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000011295}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000011295}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACTA01140604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002926376.1; XM_002926330.2.
DR   STRING; 9646.ENSAMEP00000011295; -.
DR   Ensembl; ENSAMET00000011776; ENSAMEP00000011295; ENSAMEG00000010733.
DR   GeneID; 100480874; -.
DR   KEGG; aml:100480874; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; G1LW44; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    104       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   269 AA;  30802 MW;  F379BA99F0279252 CRC64;
     MARVPEPTSE MSYYCSDSEN DLSFEADGPS KMKCCFQDLN SSFLEDEGIQ LHISHQLQNK
     SLRHFVSVVV ALEKLKKISL PSSQLFQDDD LKNVFSCIFE EEPIICEAYD DDALVCDAPL
     QSLDCKFWDV NQKSLVLYNS YELRALHLNG SSVNQQAVFR MSFVQGDESS NKIPVALCIK
     EKNLYLSCVM KDGKPTLQLE MLDPRVYPKK KMEKRFVFNK TQIKKRLEFE SAQFPNWYIS
     TSQAEEMPVF LGNTKGGQDI TDFTMELTS
//
ID   G1LW58_AILME            Unreviewed;       265 AA.
AC   G1LW58;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 31.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000011309};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSAMEP00000011309};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011309, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000011309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000011309}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000011309}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACTA01188595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011232040.1; XM_011233738.1.
DR   STRING; 9646.ENSAMEP00000011309; -.
DR   Ensembl; ENSAMET00000011791; ENSAMEP00000011309; ENSAMEG00000010754.
DR   GeneID; 100481122; -.
DR   KEGG; aml:100481122; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; G1LW58; -.
DR   KO; K04383; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    104       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   265 AA;  30293 MW;  F7C9152C9B4BE9B8 CRC64;
     MAKVPDLFED LKNCCSENEE YSSEIDHLSL NQKSFYDVSY DPLHEDCMSL STSETSKTSQ
     LTFKENVVVV ATNGKILKKR RLSLNQFITD DDLEAITNDA EEEIMKPRSA AYNFSGNEKY
     NYMRIIKSQF ILNDNLNQSI IQQPGGNYLM AAALQNLDDA AKFDMGAYTS EDSKLPVTLR
     ISKTRLFVSA QNEDEPVLLK EMPETPKTIR DETNLLFFWE RHGTKNYFTS VAQPKLFIAT
     QEQKLVHMAR GQPSITDFQI LETQP
//
ID   G1MZF3_MELGA            Unreviewed;       205 AA.
AC   G1MZF3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   11-MAY-2016, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMGAP00000004415};
DE   Flags: Fragment;
GN   Name=IL18 {ECO:0000313|Ensembl:ENSMGAP00000004415};
OS   Meleagris gallopavo (Common turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000004415, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000004415, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000004415}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000004415}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9103.ENSMGAP00000004415; -.
DR   Ensembl; ENSMGAT00000005132; ENSMGAP00000004415; ENSMGAG00000004590.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; G1MZF3; -.
DR   OMA; AFKFEYS; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000001645; Chromosome 26.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0035710; P:CD4-positive, alpha-beta T cell activation; ISS:AgBase.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:1902715; P:positive regulation of interferon-gamma secretion; ISS:AgBase.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0050671; P:positive regulation of lymphocyte proliferation; ISS:AgBase.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSMGAP00000004415}.
SQ   SEQUENCE   205 AA;  23684 MW;  F48C5BAD6C265BD1 CRC64;
     SHSSHPSVKM SCEEIAVCAV RLRENLCLYF EELECDAFCK EKTIKRLFRN VNSQLLVVRP
     DLNMAAFEDV TDQEVKSGSG MYFDIHCYKT TAPSAGMPVA FSVQVEDKSY YMCCEKEHGK
     MVVRFREGEV PKDIPGESNM IFFKKTFTSC SSKAFKFEYS LEQGMFLAFE EEDSLRKLIL
     KKLPREDEVD ETTKFVTSRN ERHNL
//
ID   G1NSN5_MYOLU            Unreviewed;       269 AA.
AC   G1NSN5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000000151};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSMLUP00000000151};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000151, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000000151}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The genome sequence of Myotis lucifugus (Bat).";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMLUP00000000151}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000000151}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02046449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006103068.1; XM_006103006.2.
DR   RefSeq; XP_014300941.1; XM_014445455.1.
DR   STRING; 59463.ENSMLUP00000000151; -.
DR   Ensembl; ENSMLUT00000000165; ENSMLUP00000000151; ENSMLUG00000000166.
DR   GeneID; 102426867; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; G1NSN5; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    108       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   269 AA;  30843 MW;  AD94C3E08FD8FDB8 CRC64;
     MAQVPDLFED LKSCYSENEE YSSEIDQLSL NQKSFYDASY DPFPKNCMGQ FLSLSTSETS
     KTSQLTYKES VVVVAANGKI LKKRRLSFNQ FITDDDLETI ANDPEEEILQ PTSVPYSFQG
     NVKYPFMRVI KRHFILNDNL HQSIIRDTSG RFLMAATLNN MDQAVRFDMG AYKSDDLKRP
     VTLRISDTRL FLSAQNEGEP VLLKELPETP KIITDETNLL FFWESQGSKD YFESVAHPKL
     FIATKQEYQV HMASGHPSII DLQILENYA
//
ID   G1PEV6_MYOLU            Unreviewed;       268 AA.
AC   G1PEV6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 35.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000009061};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSMLUP00000009061};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000009061, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000009061}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The genome sequence of Myotis lucifugus (Bat).";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMLUP00000009061}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000009061}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02046450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006103069.1; XM_006103007.2.
DR   STRING; 59463.ENSMLUP00000009061; -.
DR   Ensembl; ENSMLUT00000009938; ENSMLUP00000009061; ENSMLUG00000009941.
DR   GeneID; 102427189; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; G1PEV6; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    104       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30552 MW;  0BAD7F946B61D621 CRC64;
     MAAVPELANE VMAYYSDDEN GLFFEADGPQ QTKCSFQDLD LSPLGDGSIQ LKVSQQLYNS
     SFRRAVSVVI AVEKLRKVHM VCPQDFQDDD LRSLFFFIFK EESIDCMWDG SYECDASLQS
     LHCRLRDINQ KSLVLSGPHE LQALHLNGED VNQQVVFCMS FVPGDENIDK IPVALGIKEK
     NLYLSCVVKD KKPTLQLETF DPHGQSKKKI DRRFIFHKKE IRDKVEFESA MYPNWYISTS
     QADQTPVFLG STKGGQDITD FTMEILTH
//
ID   G1PJB1_MYOLU            Unreviewed;       148 AA.
AC   G1PJB1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000010833};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010833, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000010833, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000010833}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000010833}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02046459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMLUT00000011890; ENSMLUP00000010833; ENSMLUG00000011895.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1PJB1; -.
DR   OMA; KEINIMD; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   148 AA;  16528 MW;  692A416F98D33578 CRC64;
     SPRTFSIRDP QQMVCVLEGE SLIAVPSDNN VKPATIFSVP CTDPDISNEK GSPIYLGVKE
     DLCLFCAEIE GRPTLQLKKE SIMKLYEEKK AQKSFLFLRG IEGSTSTFQS VACLGWYIAT
     SLQARQPVTL TNDRGKTYNT NFYFSSLQ
//
ID   G1PJB7_MYOLU            Unreviewed;       152 AA.
AC   G1PJB7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000010839};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSMLUP00000010839};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010839, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000010839}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The genome sequence of Myotis lucifugus (Bat).";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMLUP00000010839}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000010839}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02046459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000010839; -.
DR   Ensembl; ENSMLUT00000011896; ENSMLUP00000010839; ENSMLUG00000011898.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1PJB7; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  17011 MW;  94262097751817F0 CRC64;
     MCSLPMARYY IIKDADQQAL YIRGDQLLVG DPDADNCCAE KICILPNRGL DRTQLPIFLG
     IQGGRRCLAC VEAGEGPALK LEDVSIEDLY KGGEQATRFT FFQRSLGSAF RLEAAAWPGW
     FLCGPAEPQQ PVRLAEETEP SIRTEFYFEQ SR
//
ID   G1PJC5_MYOLU            Unreviewed;       176 AA.
AC   G1PJC5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   08-JUN-2016, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000010847};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSMLUP00000010847};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010847, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000010847}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The genome sequence of Myotis lucifugus (Bat).";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMLUP00000010847}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000010847}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02046461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006103072.1; XM_006103010.2.
DR   STRING; 59463.ENSMLUP00000010847; -.
DR   Ensembl; ENSMLUT00000011905; ENSMLUP00000010847; ENSMLUG00000011906.
DR   GeneID; 102428427; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1PJC5; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    176       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003418293.
SQ   SEQUENCE   176 AA;  19877 MW;  64593AA38CD6528D CRC64;
     MAICRCPLSH LISLLLFLFP SETACRPSGR RPNKMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGPNTKLEEK IDVVPVEPHT VLLGIHGGKL CLACVKAGNE IRLQLEEVNI TDLSKTTEQN
     KRFTFIRSDS GPTTTFESAA CPGWYLCTAL EADQPVSLTN EPREAVRVTK FYFQQD
//
ID   G1Q004_MYOLU            Unreviewed;       156 AA.
AC   G1Q004;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000017036};
DE   Flags: Fragment;
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSMLUP00000017036};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000017036, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000017036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The genome sequence of Myotis lucifugus (Bat).";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMLUP00000017036}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000017036}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02046459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMLUT00000027256; ENSMLUP00000017036; ENSMLUG00000025221.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1Q004; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSMLUP00000017036}.
SQ   SEQUENCE   156 AA;  17236 MW;  0B24835F451328FC CRC64;
     RMVLSGALCF RMKDAALKVL YLQDNQLLAG GVHGGKAVKG EEISVVPNRF LDDSLSPVIL
     GVQGGSQCLS CGTGQEPTLK LEPVDIMELY RSPKDSRGFT FYRRDTGLTS RFESAAFPGW
     FLCTVPEADQ PLRLSQLPGD ASWDHPIMDF YFQQCD
//
ID   G1Q0V0_MYOLU            Unreviewed;       215 AA.
AC   G1Q0V0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000017333};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSMLUP00000017333};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000017333, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000017333}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The genome sequence of Myotis lucifugus (Bat).";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMLUP00000017333}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000017333}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02046453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02046454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000017333; -.
DR   Ensembl; ENSMLUT00000027944; ENSMLUP00000017333; ENSMLUG00000024209.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1Q0V0; -.
DR   OMA; RKHTEFS; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   215 AA;  22868 MW;  58F04D5796C71649 CRC64;
     MSFQEESAGV QVDAADGGGA GAQGSAEDPA QGALEPGLSP PSLSLAAADP KVKNPEPQKF
     SFHDRDHKVL VLNGGTLIAV HKKPNTSPET FYVLASRLSS AGDKGNPVFL AVSGGKLCLY
     CEMDKKKGQP TLQLKKKKLS HLRASDTTDS KGFTFYRKEG AGNTLESAAH QGWFISTCHA
     NEHVRMTDKP GGEELIDFTF VPVSKAHMSP SEVSE
//
ID   G1Q6X4_MYOLU            Unreviewed;        84 AA.
AC   G1Q6X4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000019457};
DE   Flags: Fragment;
GN   Name=IL18 {ECO:0000313|Ensembl:ENSMLUP00000019457};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000019457, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000019457}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The genome sequence of Myotis lucifugus (Bat).";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMLUP00000019457}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000019457}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02026596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000019457; -.
DR   Ensembl; ENSMLUT00000030242; ENSMLUP00000019457; ENSMLUG00000027380.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; ECEENAS; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSMLUP00000019457}.
SQ   SEQUENCE   84 AA;  9682 MW;  F32588EDDD762244 CRC64;
     LESDYFGRIE PRLSIIRNVN NQVLFVYQGS HAVFEDMTDS ECEENASQTK IIIYTYKDSY
     PRGMAVTLSV KCPEMFTLSC MNKN
//
ID   G1Q8I1_MYOLU            Unreviewed;       160 AA.
AC   G1Q8I1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000020014};
DE   Flags: Fragment;
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000020014, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000020014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Genome Sequencing Platform;
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Myotis lucifugus (Bat).";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMLUP00000020014}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000020014}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02046459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMLUT00000022341; ENSMLUP00000020014; ENSMLUG00000024015.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1Q8I1; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSMLUP00000020014}.
SQ   SEQUENCE   160 AA;  17764 MW;  4B3A893918E9625E CRC64;
     VLCAFPPRHL VGMGRPGTFS IRDRQQMVWV LEGESLIAVP SSKRVKPATV FSVPCTDPDI
     SNEKGSPIYL GVKEDLCLFC AEIEGRPTLQ LKKESIMKLY QEKKAQKSFL FLRGIEGSTS
     SFQSVACLGW FIATSSQVGQ PVTLTNDRGK TYNTNFYFSS
//
ID   G1QCK6_MYOLU            Unreviewed;       165 AA.
AC   G1QCK6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000021439};
DE   Flags: Fragment;
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021439, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000021439}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Genome Sequencing Platform;
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Myotis lucifugus (Bat).";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMLUP00000021439}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000021439}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02062728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMLUT00000028510; ENSMLUP00000021439; ENSMLUG00000027712.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1QCK6; -.
DR   OMA; YAESAPN; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSMLUP00000021439}.
SQ   SEQUENCE   165 AA;  18285 MW;  7615E9C785E714A7 CRC64;
     VTSRVLCAFS PCHLVGIGSP MTFSIRDPQQ MVWVLEGESL IAVPSDNNVK PATVFSVPCT
     DPDISNEKGS PIYLGVKEDL CLFCAEIEGR PTLQLKKESI MKLYEEKKAQ KSFLFLRGIE
     GSTSTFQSVA CLGWYIATSL QARQPVTLTN DRGKTYNTNF YFSSL
//
ID   G1QMS9_NOMLE            Unreviewed;       271 AA.
AC   G1QMS9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000002245};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSNLEP00000002245};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002245};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000002245}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000002245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000002245}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ADFV01102533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01102534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000002245; -.
DR   Ensembl; ENSNLET00000002367; ENSNLEP00000002245; ENSNLEG00000001878.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; G1QMS9; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   Proteomes; UP000001073; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   271 AA;  30837 MW;  E2443EC65BA72B8F CRC64;
     MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ SVSLSISETS
     KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI TNDSEEEIIK PRSAPFSFLS
     NVKYNFMRII KHEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI
     TKGLFFHKSI VKFYSYSQDK YILKREMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP
     NLFIATKQDY WVCLAGGPPS ITDFQILEDQ A
//
ID   G1QMW1_NOMLE            Unreviewed;       294 AA.
AC   G1QMW1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 2.
DT   11-MAY-2016, entry version 36.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000002277};
DE   Flags: Fragment;
GN   Name=IL1B {ECO:0000313|Ensembl:ENSNLEP00000002277};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002277};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000002277}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000002277}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ADFV01102534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000002277; -.
DR   Ensembl; ENSNLET00000002401; ENSNLEP00000002277; ENSNLEG00000001886.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; G1QMW1; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001073; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Cytokine {ECO:0000256|RuleBase:RU003753};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN       26    128       IL1_propep. {ECO:0000259|Pfam:PF02394}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSNLEP00000002277}.
SQ   SEQUENCE   294 AA;  33639 MW;  08F55478BA5A8D70 CRC64;
     RGTRHNRLLW DSLQPIFIAQ VSEAAMAEVP ELASEMMAYY SGNEDDLFFE VDGPKQMKCP
     FQDLDLCPLD GGIQLRISHQ HYSKGFRQAV SVVVAMEKLR KMLVPCPQTF QDNDLSTLFP
     FIFEEEPIFF DTWDDEAYVH DAPVRSLNCT LRDAQQKSLV MSGPYELKAL HLQGQDMEQQ
     VVFSMSFVQG EESNDKIPVA LGLKEKNLYL SCVLKDDKPT LQLESVDPKN YPKKKMEKRF
     VFNKIEINNK LEFESAQFPN WYISTSQAEN MPVFLGGTKG GQDITDFTMQ FVSS
//
ID   G1QN29_NOMLE            Unreviewed;       218 AA.
AC   G1QN29;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000002345};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSNLEP00000002345};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002345};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000002345}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000002345}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000002345}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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DR   EMBL; ADFV01102540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003277735.1; XM_003277687.3.
DR   STRING; 61853.ENSNLEP00000002345; -.
DR   Ensembl; ENSNLET00000002474; ENSNLEP00000002345; ENSNLEG00000001913.
DR   GeneID; 100587687; -.
DR   KEGG; nle:100587687; -.
DR   CTD; 27178; -.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1QN29; -.
DR   KO; K05485; -.
DR   OMA; RKHTEFS; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001073; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   218 AA;  24007 MW;  AEFDDE47FEECE5BE CRC64;
     MSFVGENSGV KMGSEDWEKD EPQCCLEDPA GSPLEPGPSL PATNFVHTSP KVKNLNPKKF
     SIHDQDHKVL VLDSGNLIAV PDKNYIRPEI FFALASSLSS ASAEKGSPIL LGVSKGEFCL
     YCDKDKGQSH PSLQLKKKKL MKLAGQKESA RRPFIFYRAQ VGSRNMLESA AHPGWFVCTS
     CNCNEPVGVT DKFENRKHIE FSFQPVCKAE MSPSEVSD
//
ID   G1QN31_NOMLE            Unreviewed;       169 AA.
AC   G1QN31;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000002347};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSNLEP00000002347};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002347};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000002347}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000002347}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000002347}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   EMBL; ADFV01102543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01102544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003277739.1; XM_003277691.2.
DR   Ensembl; ENSNLET00000002475; ENSNLEP00000002347; ENSNLEG00000001973.
DR   GeneID; 100588672; -.
DR   KEGG; nle:100588672; -.
DR   CTD; 56300; -.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1QN31; -.
DR   KO; K05487; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001073; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   169 AA;  18722 MW;  927824E050FB6935 CRC64;
     MRGTPGDPAG GGRAVYQSMY KPITGTINDL NQQVWTLQGQ ILVAVPRSDS VTPVTVTVIT
     CKYPEALEQG RGDPIYLGIQ NPEMCLHCEK VGGQPTLQLK EQKIMDLYGQ PEPVKPFLFY
     RVKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND
//
ID   G1QN77_NOMLE            Unreviewed;       155 AA.
AC   G1QN77;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000002393};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSNLEP00000002393};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002393};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000002393}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000002393}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000002393}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ADFV01102545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003277740.1; XM_003277692.2.
DR   RefSeq; XP_003277741.1; XM_003277693.1.
DR   Ensembl; ENSNLET00000002522; ENSNLEP00000002393; ENSNLEG00000001974.
DR   GeneID; 100589009; -.
DR   KEGG; nle:100589009; -.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1QN77; -.
DR   KO; K05483; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001073; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  16978 MW;  F42AB5F70D8677C9 CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
     VQGGSQCLSC GAGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF
     LCTVPEADQP VRLTQLPENA SWNAPITDFY FQQCD
//
ID   G1QN82_NOMLE            Unreviewed;       109 AA.
AC   G1QN82;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000002398};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSNLEP00000002398};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002398};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000002398}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000002398}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000002398}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ADFV01102545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000002527; ENSNLEP00000002398; ENSNLEG00000002012.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1QN82; -.
DR   OMA; SACTELY; -.
DR   OrthoDB; EOG747PKM; -.
DR   Proteomes; UP000001073; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   109 AA;  11888 MW;  28B8615C245DC68B CRC64;
     MCSLPTARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICILPNRGL DRTKVPIFLG
     IQGGSRCLAC VETGEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSA
//
ID   G1QNA8_NOMLE            Unreviewed;       163 AA.
AC   G1QNA8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 2.
DT   11-MAY-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000002424};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSNLEP00000002424};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002424, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000002424}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000002424}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000002424}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ADFV01102547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01102548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000002424; -.
DR   Ensembl; ENSNLET00000002553; ENSNLEP00000002424; ENSNLEG00000002015.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1QNA8; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001073; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   163 AA;  18421 MW;  BDCC4861692A8E0A CRC64;
     MHCSCGWETV CRPFGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV
     PIKPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFT FIRSDSGPTT
     SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVVVTKFYFQ EDE
//
ID   G1R6S4_NOMLE            Unreviewed;       193 AA.
AC   G1R6S4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 2.
DT   11-MAY-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000008896};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSNLEP00000008896};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000008896, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000008896}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000008896}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000008896}.
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DR   EMBL; ADFV01056565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003253197.1; XM_003253149.3.
DR   STRING; 61853.ENSNLEP00000008896; -.
DR   Ensembl; ENSNLET00000009316; ENSNLEP00000008896; ENSNLEG00000007295.
DR   GeneID; 100585066; -.
DR   KEGG; nle:100585066; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; G1R6S4; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000001073; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22363 MW;  93D83138897F00BA CRC64;
     MAAEPVEDNC VNFVAMKFID NTLYFIAEDD ENLESDYFHK MESKLSIIRN LNDQVLFIDQ
     GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SKPRGMAVTI SVKCEKISTL SCENKIISFK
     EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKKDEL
     GDRAIMFTVQ NEA
//
ID   G1SNI9_RABIT            Unreviewed;       297 AA.
AC   G1SNI9;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   11-MAY-2016, entry version 19.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000004555};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSOCUP00000004555};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004555, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000004555, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000004555}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004555};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000004555}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAGW02009348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9986.ENSOCUP00000004555; -.
DR   Ensembl; ENSOCUT00000005254; ENSOCUP00000004555; ENSOCUG00000005255.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   HOVERGEN; HBG000388; -.
DR   Proteomes; UP000001811; Chromosome 1.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    297       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003421586.
SQ   SEQUENCE   297 AA;  33741 MW;  BA07D80E87980E72 CRC64;
     MAQYLQFILI GCFNVTTLTC SCKDRHSKLM LSYSMCKKTL KIISLHKTKV ATVPHKLQRL
     LGPEAYCVPG LATLAAADRR DRGEERNLKA SRTLPVAGND LAGIEMAAEP EEACINFVGM
     KFIDNTLYFI TENDENLESD YFGKLEPKIS IIRNLNDQVL FMDQGQQPVF EDMPDSDCIE
     NAPQTIFIIY MYKDSNTRGM AVSLSVKCKK IFTLSCENKI ISFKELTPPN DINDTKSDII
     FFQKHLAGQK DKMQFESSLY DGYFLACGKE KDLFKLVLKR KDDKNDKSVI FSVQNKN
//
ID   G1SNP0_RABIT            Unreviewed;       152 AA.
AC   G1SNP0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-MAY-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000004612};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSOCUP00000004612};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004612, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000004612, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000004612}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004612};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000004612}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAGW02007339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002709657.1; XM_002709611.2.
DR   STRING; 9986.ENSOCUP00000004612; -.
DR   Ensembl; ENSOCUT00000005317; ENSOCUP00000004612; ENSOCUG00000005319.
DR   GeneID; 100341760; -.
DR   KEGG; ocu:100341760; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1SNP0; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001811; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16943 MW;  58C395576AE3BB89 CRC64;
     MCSLPMARYY IIKDTDQKVL YIRDGQLLVG DPDVDKCSAE KICILPNRDL DRAKVPILLG
     TQGGSRCLAC VETEAGPSLQ LEDVNIEDLY KGGEEATRFT FFQSSLGSAF RLEAAAWPGW
     FVSGPAEPEQ PVQLTKESEP TARTEFYFEQ SR
//
ID   G1SRG0_RABIT            Unreviewed;       162 AA.
AC   G1SRG0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000005756};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSOCUP00000005756};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005756, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000005756, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000005756}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005756};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000005756}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAGW02007345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002709614.2; XM_002709568.2.
DR   Ensembl; ENSOCUT00000006659; ENSOCUP00000005756; ENSOCUG00000006660.
DR   GeneID; 100355269; -.
DR   KEGG; ocu:100355269; -.
DR   CTD; 56300; -.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1SRG0; -.
DR   KO; K05487; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001811; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   162 AA;  17935 MW;  89B636F95E6232C5 CRC64;
     MSGAGQQIHG AMSEPYVGKL SDLDQQVWIL QGQTLVTVPR SSNAAAVTIT VMPCKYPEAL
     EQGKGVPIYL GIQNPKMCLF CEDTGGQPTL QLKEQEILDL YNHTEPVKPF LFYHMQTGRT
     STFESVAFPG WFIASFKKGQ PIFLTSNQGK LYNTAFNLDL KA
//
ID   G1T0E8_RABIT            Unreviewed;       155 AA.
AC   G1T0E8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   11-MAY-2016, entry version 31.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000009459};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSOCUP00000009459};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009459, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000009459, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000009459}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009459};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000009459}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAGW02007341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002709656.1; XM_002709610.2.
DR   STRING; 9986.ENSOCUP00000009459; -.
DR   Ensembl; ENSOCUT00000010997; ENSOCUP00000009459; ENSOCUG00000010998.
DR   GeneID; 100340988; -.
DR   KEGG; ocu:100340988; -.
DR   CTD; 26525; -.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1T0E8; -.
DR   KO; K05483; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001811; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  17165 MW;  8AA4BAAEF0AFF41E CRC64;
     MVLSGALCFR MKDSALKVLY LHNDQLLAGG LHAGKVIKGE EISVVPNRSL DARLSPVILG
     VQGGSRCLSC GMEQEPTLKL EPVNIMELYR DAQESKSFTF YRRDMGLTSS FESAAYPGWF
     LCTVPEADQP VRLAQIPDNA GWDAPITDFY FQQCD
//
ID   G1T8I3_RABIT            Unreviewed;       160 AA.
AC   G1T8I3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   06-JUL-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000012884};
GN   Name=IL36A {ECO:0000313|Ensembl:ENSOCUP00000012884};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000012884, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000012884, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000012884}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000012884};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000012884}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAGW02007344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9986.ENSOCUP00000012884; -.
DR   Ensembl; ENSOCUT00000014993; ENSOCUP00000012884; ENSOCUG00000014998.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1T8I3; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001811; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   160 AA;  18026 MW;  7AC0298E44BB73AB CRC64;
     LTFSVALSTP APVLRHIQDL NHQVWVVQDQ TLTAVPRKHS MVPATVSLIP CQYPETLETE
     KGIPMYLGLD KPDVCLFCTK TREQPMLQLE DKNIMTLYHH PEPVKPFLFY HSKSGRTSTF
     ESVAFPGWFI AVCSEGGCPL FLTQDLGKAY TTDFELTPVN
//
ID   G1TVC0_RABIT            Unreviewed;       187 AA.
AC   G1TVC0;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   08-JUN-2016, entry version 21.
DE   SubName: Full=Interleukin-1 receptor antagonist protein {ECO:0000313|Ensembl:ENSOCUP00000021003};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSOCUP00000021003};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000021003, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000021003, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000021003}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000021003};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000021003}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAGW02007339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9986.ENSOCUP00000003600; -.
DR   Ensembl; ENSOCUT00000021692; ENSOCUP00000021003; ENSOCUG00000004161.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000001811; Chromosome 2.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   187 AA;  20851 MW;  E852EA8789FF626A CRC64;
     MLPLNAAAQS AARGRKSSGL HTTHKTLPMA SETACRPSGK RPCRMQAFRI WDVNQKTFYL
     RNNQLVAGYL QGPNAKLEER IDVVPLEPQL LFLGIQRGKL CLSCVKSGDK MKLHLEAVNI
     TDLGKNKEQD KRFTFIRSNS GPTTTFESAS CPGWFLCTAL EADQPVSLTN TPDDSIVVTK
     FYFQEDQ
//
ID   G1TXR4_RABIT            Unreviewed;       259 AA.
AC   G1TXR4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   08-JUN-2016, entry version 35.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|Ensembl:ENSOCUP00000021869};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSOCUP00000021869};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000021869, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000021869, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000021869}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000021869};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000021869}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAGW02007347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02007348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9986.ENSOCUP00000021869; -.
DR   Ensembl; ENSOCUT00000025102; ENSOCUP00000021869; ENSOCUG00000023958.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; G1TXR4; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001811; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN       26     96       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   259 AA;  29455 MW;  89AD58001C14EF4E CRC64;
     ISEVPSTSLL LPDYLHAPTD CLVSPQSCFQ DLDLCCPDEG IQLRISCQPY NKSFRQVLSV
     VVALEKLRQK AVPCPQAFQD DGLRTFFSLI FEEEPVSAHW DDYSLSVMQV RSLHCLQDAQ
     QKSLVLSGTY ELKALHLNAE NLNQQVVFSM SFVQGEESND KIPVALGLRG KNLYLSCVMK
     DDKPTLQLES VDPNRYPKKK MEKRFVFNKI EIKDKLEFES AQFPNWYIST SQTEYMPVFL
     GNNSGGQDLI DFSMEFVSS
//
ID   G1U1C7_RABIT            Unreviewed;       255 AA.
AC   G1U1C7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000023161};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSOCUP00000023161};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000023161, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000023161, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000023161}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000023161};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000023161}.
CC   -----------------------------------------------------------------------
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DR   EMBL; AAGW02007345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9986.ENSOCUP00000023161; -.
DR   Ensembl; ENSOCUT00000028233; ENSOCUP00000023161; ENSOCUG00000024654.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G1U1C7; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001811; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   255 AA;  28635 MW;  852756E55759968F CRC64;
     MRTSSRLLRL RKTEDRVPHI HDRATDHRDS RLRSFPRSHH LLIISLMSKM SLLEKNSGVK
     MDSEDGEKAE PQDCSGDPAG SPQEPGPSFP SVDSVQSKSL VKFQEPEKFN IRDGDQKVLV
     LDCEILKAIP HKAYILPETF FVLASYYHSA PPEKGSPILL AVSKGELCLC CVKAQGKIFP
     SLQLKKKKLE DLVTEKEQAQ RPFVFYKADV GSRSTLESAA HTGWFLCTSC SSGEPVRLTK
     TVGRKKQVEF HFIKL
//
ID   G3H2H9_CRIGR            Unreviewed;       196 AA.
AC   G3H2H9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Interleukin-18 {ECO:0000313|EMBL:EGW03821.1};
DE   SubName: Full=Interleukin-18-like protein {ECO:0000313|EMBL:ERE76163.1};
GN   ORFNames=H671_4g12049 {ECO:0000313|EMBL:ERE76163.1},
GN   I79_004392 {ECO:0000313|EMBL:EGW03821.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03821.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
RN   [2] {ECO:0000313|EMBL:EGW03821.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000030759}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17A/GY {ECO:0000313|Proteomes:UP000030759};
RX   PubMed=23929341; DOI=10.1038/nbt.2645;
RA   Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B.,
RA   Kofler R., Romand S., Hesse F., Budach W.E., Galosy S., Muller D.,
RA   Noll T., Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A.,
RA   Goesmann A., Helk B., Mott J.E., Puhler A., Borth N.;
RT   "Chinese hamster genome sequenced from sorted chromosomes.";
RL   Nat. Biotechnol. 31:694-695(2013).
RN   [4] {ECO:0000313|EMBL:ERE76163.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=17A/GY {ECO:0000313|EMBL:ERE76163.1};
RA   Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B.,
RA   Kofler R., Romand S., Hesse F., Budach W.E., Galosy S., Muller D.,
RA   Noll T., Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A.,
RA   Goesmann A., Helk B., Mott J.E., Puehler A., Borth N.;
RT   "Chinese hamster genome sequenced from sorted chromosomes.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; JH000115; EGW03821.1; -; Genomic_DNA.
DR   EMBL; KE674738; ERE76163.1; -; Genomic_DNA.
DR   RefSeq; XP_007619097.1; XM_007620907.1.
DR   RefSeq; XP_007619098.1; XM_007620908.1.
DR   RefSeq; XP_007619099.1; XM_007620909.1.
DR   RefSeq; XP_007619100.1; XM_007620910.1.
DR   RefSeq; XP_007619101.1; XM_007620911.1.
DR   RefSeq; XP_007619102.1; XM_007620912.1.
DR   RefSeq; XP_007627573.1; XM_007629383.1.
DR   RefSeq; XP_007627579.1; XM_007629389.1.
DR   RefSeq; XP_007627588.1; XM_007629398.1.
DR   RefSeq; XP_007627595.1; XM_007629405.1.
DR   RefSeq; XP_007627602.1; XM_007629412.1.
DR   GeneID; 100750469; -.
DR   KEGG; cge:100750469; -.
DR   CTD; 3606; -.
DR   KO; K05482; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   Proteomes; UP000030759; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   196 AA;  22581 MW;  3D3BE6467E39C3C6 CRC64;
     MMAAVQEEGS CINFREMAFI DNTLYFTPED DDGDLESDHF GRLDRVSTVV RNMNDQVLFV
     DRRKSPVFED MTDADIWANK PHTRLIIYMY KDSDAGGMAV TLSVEDQKMF TLSCKNKVIS
     FQEMDPPEYI DDTKSDIIFF ERGVPGHNKM QFESSLYKGH FLACEKEDDV FRLILKEKDE
     NGDKSVMFTV ATLPHS
//
ID   G3I1B0_CRIGR            Unreviewed;       237 AA.
AC   G3I1B0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:EGV93329.1};
GN   ORFNames=I79_017162 {ECO:0000313|EMBL:EGV93329.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV93329.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
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DR   EMBL; JH001060; EGV93329.1; -; Genomic_DNA.
DR   InParanoid; G3I1B0; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1     72       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   237 AA;  27230 MW;  732C651D92713A7F CRC64;
     MKCCFQSLDL SYPDESIQLQ ITKQHHNKSF RQVVSVIVAV EKLWNIPVAG PWTLQDEDLR
     TFFSFIFEEE PIFSDSWDDE LIVADVPIRQ LHCRLRDEQQ KCLVLSDPCE LKALHLNGQN
     INQQVVFSMS FVQGETSSNK TPVALGIKGK NLYLSCVMKG DMPTLQLESV DPKQYPKKKM
     EKRFVFNKIE VKSRVEFESA QFPNWYISTS QAEHKPVFLG NNSGQDLVDF TMESVSS
//
ID   G3IHF8_CRIGR            Unreviewed;       157 AA.
AC   G3IHF8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Interleukin-1 receptor antagonist protein {ECO:0000313|EMBL:EGW11852.1};
GN   ORFNames=I79_023248 {ECO:0000313|EMBL:EGW11852.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW11852.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JH002772; EGW11852.1; -; Genomic_DNA.
DR   InParanoid; G3IHF8; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Receptor {ECO:0000313|EMBL:EGW11852.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   157 AA;  17306 MW;  84F988387E682FE6 CRC64;
     MQAFSLKAQH RSKGTNAPSY AEDLICPGPC PELLGCSKLP KESISSLTEK IDMVTTDLHS
     VFLGIHGGKL CLSCVKSGDG IKLQLEEMNI TDLSKNKEQD KRFTFIRSEK GPTTSFESAA
     CPGWFLCTAV EADRPVSLTN KPEEPLTVTK FYFQEDQ
//
ID   G3IHF9_CRIGR            Unreviewed;       152 AA.
AC   G3IHF9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Interleukin-1 family member 10 {ECO:0000313|EMBL:EGW11853.1};
GN   ORFNames=I79_023249 {ECO:0000313|EMBL:EGW11853.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW11853.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
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DR   EMBL; JH002772; EGW11853.1; -; Genomic_DNA.
DR   RefSeq; XP_003514153.1; XM_003514105.1.
DR   RefSeq; XP_007637153.1; XM_007638963.1.
DR   GeneID; 100752197; -.
DR   KEGG; cge:100752197; -.
DR   CTD; 84639; -.
DR   InParanoid; G3IHF9; -.
DR   KO; K05488; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16934 MW;  AC439DFFEF7E0840 CRC64;
     MCSLPMARYY IIKDAHQKVL YTRNGQLLVG DPDADNCSAE KICILPNRGL DRSKVPIFLG
     IQGGSCCLAC VETREGPSLK LEDVSIEDLY KGGEQTTRFT FFQRSLGSAF RLEAAACPGW
     FLCGPVEPQQ PVQLTKESEP STLTEFYFEQ SR
//
ID   G3IHG0_CRIGR            Unreviewed;       145 AA.
AC   G3IHG0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Interleukin-1 family member 5 {ECO:0000313|EMBL:EGW11854.1};
GN   ORFNames=I79_023250 {ECO:0000313|EMBL:EGW11854.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW11854.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JH002772; EGW11854.1; -; Genomic_DNA.
DR   InParanoid; G3IHG0; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   145 AA;  15912 MW;  5C08A57AAFC97D21 CRC64;
     MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRTL DASLSPVILG VQGGSQCLSC
     GTEKEPVLKL EPVNIMELYL GTKESKSFTF YRRDMGLTSS FESAAYPGWF LGTVPEADQP
     VRLTQIPEDA AWDAPITDFY FQQCD
//
ID   G3IKA6_CRIGR            Unreviewed;       143 AA.
AC   G3IKA6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 18.
DE   SubName: Full=Interleukin-1 family member 9 {ECO:0000313|EMBL:EGW10135.1};
GN   ORFNames=I79_024305 {ECO:0000313|EMBL:EGW10135.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW10135.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JH003546; EGW10135.1; -; Genomic_DNA.
DR   InParanoid; G3IKA6; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   143 AA;  16182 MW;  F1C2979436363DE5 CRC64;
     MLLCYTRTIR AVCLLGSERN CCLPIIIVTI AVLPCKYPES LEQDKGIPIY MGIQNPDKCM
     LCEEVDGQPT LQLKEENILD LYNHPEPKRP FLFYHTQTGR TSTFESVAFP GSFIASSKNG
     QPIFLTSEQG KYYNINFNLQ IGP
//
ID   G3IN67_CRIGR            Unreviewed;       138 AA.
AC   G3IN67;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Interleukin-1 family member 8 {ECO:0000313|EMBL:EGW13888.1};
GN   ORFNames=I79_025379 {ECO:0000313|EMBL:EGW13888.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13888.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JH005520; EGW13888.1; -; Genomic_DNA.
DR   InParanoid; G3IN67; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   138 AA;  15286 MW;  52416A44DB593A6B CRC64;
     MVWVLTGNSL TAVPARNNVK PVSLSLIACR DTEFQDTEKG NLVILGIESQ SLCLFCAENG
     GTPTLQLKNV DIMEMYSDNK VQKAFLFYHS KEGSTSAFQS VSYPGWFIAT SSTARQAIIL
     TQQRGEAHNT NFYLEPED
//
ID   G3MX81_BOVIN            Unreviewed;       161 AA.
AC   G3MX81;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000054141};
GN   Name=IL36A {ECO:0000313|Ensembl:ENSBTAP00000054141};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000054141, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000054141, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054141,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000054141}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054141};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000054141}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02031090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; G3MX81; -.
DR   Ensembl; ENSBTAT00000065203; ENSBTAP00000054141; ENSBTAG00000002087.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3MX81; -.
DR   OMA; PGWFIAV; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-BTA-449147; Signaling by Interleukins.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   161 AA;  18188 MW;  AEE98E9EB595C00D CRC64;
     MEGQKKLERI HPILVNIQDI NHLVWVLQGQ TLTAVPRKDQ MDPVTVTLVS CKYTETLEKG
     RGNPVYLGLK EPELCLFCTK VKGQPTLQLQ ERNIMDLYHQ TEPVKPFLFY HDQNGRASSF
     ESVAFPGWFI GSCSCGGCPV IITQELGKIY TTDFGFTVLQ P
//
ID   G3MYY5_BOVIN            Unreviewed;       138 AA.
AC   G3MYY5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   08-JUN-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000054774};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSBTAP00000054774};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000054774, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000054774, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054774,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000054774}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054774};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000054774}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02031090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; G3MYY5; -.
DR   Ensembl; ENSBTAT00000065155; ENSBTAP00000054774; ENSBTAG00000002088.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   Reactome; R-BTA-449147; Signaling by Interleukins.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   138 AA;  15464 MW;  78AD2C07B6BC4CB0 CRC64;
     MVWVVKGNSL IAVPSSNNIK PVILSLIACR DMEFNKEGNG TPHYLGIKDK NLCLYCTEIQ
     GYPTLQLKEE NIMNLYNKPK GEKCFLFYRN DEGSTVVFQS VSYPGWFIAT SSEAGHPVTL
     TKERGTVQST NYYLEGGL
//
ID   G3PNV4_GASAC            Unreviewed;       262 AA.
AC   G3PNV4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Interleukin-1beta {ECO:0000313|EMBL:CCV66729.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000019287};
GN   Name=il1b {ECO:0000313|EMBL:CCV66729.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000019287, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000019287}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000019287}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:CCV66729.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Kead kidney {ECO:0000313|EMBL:CCV66729.1};
RA   Angosto D., Montero J., Lopez-Munoz A., Sarropoulou E., Bird S.,
RA   Garcia-Alcazar A., Meseguer J., Sepulcre M.P., Mulero V.;
RT   "Identification and functional characterization of a new IL-1 family
RT   member, IL-1Fm2, in most evolutionarily advanced fish.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; HF936681; CCV66729.1; -; mRNA.
DR   STRING; 69293.ENSGACP00000019287; -.
DR   Ensembl; ENSGACT00000019325; ENSGACP00000019287; ENSGACG00000014611.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007635};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:CCV66729.1}.
FT   NON_TER     262    262       {ECO:0000313|EMBL:CCV66729.1}.
SQ   SEQUENCE   262 AA;  29135 MW;  FEB5F325BAA7FC94 CRC64;
     MESVRESNGS GAWSPKMPQG MDFEISRHPL TMKQVVNLII AMERFKGDGS ELLMSSEFRD
     EDMLNIMLDG LVEEEIVTLC SSPPHLQISW TGEQQCSITD QEKRSLIRVP NSMQLHAVML
     QGGSEAKKVL MTMSAYLHPA PSVPGQTVAL GIRGTNLYLC CRKDGAEPTL HLEAVEDRST
     LSGADTSIGV NSDLVRFLFY RQDTGVNNTT LMSVAYQNWY ISTDNRQDNK PLAMCLKTSP
     RSQVFSIREE VERSSAPRVD SA
//
ID   G3PQP7_GASAC            Unreviewed;       177 AA.
AC   G3PQP7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 21.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGACP00000019932};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000019932, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000019932}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000019932}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGACP00000019932}.
CC   -----------------------------------------------------------------------
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CC   -----------------------------------------------------------------------
DR   Ensembl; ENSGACT00000019970; ENSGACP00000019932; ENSGACG00000015112.
DR   eggNOG; ENOG410JGPV; Eukaryota.
DR   eggNOG; ENOG410YT8P; LUCA.
DR   GeneTree; ENSGT00390000016316; -.
DR   InParanoid; G3PQP7; -.
DR   OMA; ASHYYLS; -.
DR   OrthoDB; EOG7M6D88; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007635};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   177 AA;  19955 MW;  99BEE58D17AC9769 CRC64;
     MVSQSSQVVL VSRGGGSFSH IKSLDTPIEH LATHQYLRGL CSENTIYASP NPGFPCTEEM
     TIYFYKSTSF SSFRGQPVVL NFSKSNCFLR CCKEGERVFL QVETCEKQKL KKISKNDEGA
     LSFVFYMKTD GTKERTFESA LHADWFIKID TTFANSVGMA NLDGRKGDES FFFVIQT
//
ID   G3QLV0_GORGO            Unreviewed;       271 AA.
AC   G3QLV0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 35.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000003468};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSGGOP00000003468};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000003468, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000003468, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000003468}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000003468}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   RefSeq; XP_004031670.1; XM_004031622.1.
DR   Ensembl; ENSGGOT00000003545; ENSGGOP00000003468; ENSGGOG00000003528.
DR   GeneID; 101129849; -.
DR   KEGG; ggo:101129849; -.
DR   CTD; 3552; -.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; G3QLV0; -.
DR   KO; K04383; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001519; Chromosome 2a.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   271 AA;  30572 MW;  1A6418C9E6155EA3 CRC64;
     MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVTY GPLHEGCMDQ SVSLSISETS
     KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI ANDSEEEIIK PRSAPFSFLS
     NVKYNFMRII KNEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI
     TVILRISKTQ LYVTAQDEDQ PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP
     NLFIATKQDY WVCLAGGPPS ITDFQILENQ A
//
ID   G3QPI4_GORGO            Unreviewed;       180 AA.
AC   G3QPI4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   08-JUN-2016, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000004479};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSGGOP00000004479};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000004479, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000004479, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000004479}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000004479}.
CC   -----------------------------------------------------------------------
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CC   -----------------------------------------------------------------------
DR   RefSeq; XP_004031690.1; XM_004031642.1.
DR   Ensembl; ENSGGOT00000004594; ENSGGOP00000004479; ENSGGOG00000004570.
DR   GeneID; 101135959; -.
DR   CTD; 3557; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3QPI4; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001519; Chromosome 2a.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   180 AA;  19886 MW;  ECB4FA19AD36E2D9 CRC64;
     MALADLYEEG GGGGGEGEDS ADSKETVCRP SGRKSSKMQA FRIWDVNQKT FYLRNNQLVA
     GYLQGPNVNL EEKIDVVPIE PHALFLGIHG GKMCLSCVKS GDETRLQLEA VNITDLSENR
     KQDKRFTFIR SDSGPTTSFE SAACPGWFLC TAMEADQPVS LTNMPDEGVM VTKFYFQEDE
//
ID   G3QU53_GORGO            Unreviewed;       269 AA.
AC   G3QU53;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000006245};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSGGOP00000006245};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006245, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000006245, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000006245}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000006245}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_004031671.1; XM_004031623.1.
DR   Ensembl; ENSGGOT00000006414; ENSGGOP00000006245; ENSGGOG00000006387.
DR   GeneID; 101130571; -.
DR   KEGG; ggo:101130571; -.
DR   CTD; 3553; -.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; G3QU53; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001519; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   269 AA;  30792 MW;  BA1DAED145ED4692 CRC64;
     MAEVPELTSE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISHQHYSKG
     FRQAVSVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR
     SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE
     KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST
     SQAENMPVFL GGTTGGQDIT DFTMQFVSS
//
ID   G3R1W6_GORGO            Unreviewed;       152 AA.
AC   G3R1W6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000009199};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSGGOP00000009199};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000009199, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000009199, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000009199}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000009199}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_004031687.1; XM_004031639.1.
DR   Ensembl; ENSGGOT00000009453; ENSGGOP00000009199; ENSGGOG00000009415.
DR   GeneID; 101135602; -.
DR   KEGG; ggo:101135602; -.
DR   CTD; 84639; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3R1W6; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001519; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16957 MW;  E4FA975E2326C338 CRC64;
     MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICILPNRGL DRTKVPIFLG
     IQGGSRCLAC VETEEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAARPGW
     FLCGPAEPQQ PVQLTKESEP SARTKFYFEQ SW
//
ID   G3R1W9_GORGO            Unreviewed;       156 AA.
AC   G3R1W9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000009202};
DE   Flags: Fragment;
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSGGOP00000009202};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000009202, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000009202, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000009202}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000009202}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSGGOT00000009456; ENSGGOP00000009202; ENSGGOG00000009418.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3R1W9; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001519; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSGGOP00000009202}.
SQ   SEQUENCE   156 AA;  17063 MW;  3F6FD68B8A648271 CRC64;
     KMVLSGALCF RMKDSALKVL YLHNNQLLAG GLHAGKVIKG EEISVVPNRW LDASLSPVIL
     GVQGGSQCLS CGAGQEPTLT LEPVNIMELY LGAKESKSFT FYRRDMGLTS SFESAAYPGW
     FLCTVPEADQ PVRLTQLPEN GGWNAPITDF YFQQCD
//
ID   G3RIH2_GORGO            Unreviewed;       193 AA.
AC   G3RIH2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000015475};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSGGOP00000015475};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000015475, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000015475, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000015475}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000015475}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSGGOT00000015920; ENSGGOP00000015475; ENSGGOG00000015869.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; G3RIH2; -.
DR   Proteomes; UP000001519; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22267 MW;  B09B8CA39F324C3A CRC64;
     MAAEPVEDNC INFVAMKFID NTLYFIGKAN ENLESDYFGK LESKLSVIRN LNDQVLFIDQ
     GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK
     EMDPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL
     GDRSIMFTVQ NED
//
ID   G3RIS6_GORGO            Unreviewed;       169 AA.
AC   G3RIS6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000015588};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSGGOP00000015588};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000015588, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000015588, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000015588}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000015588}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_004031682.1; XM_004031634.1.
DR   Ensembl; ENSGGOT00000016036; ENSGGOP00000015588; ENSGGOG00000015985.
DR   GeneID; 101133601; -.
DR   KEGG; ggo:101133601; -.
DR   CTD; 56300; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3RIS6; -.
DR   KO; K05487; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001519; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   169 AA;  18763 MW;  0E0466CABA0EAE47 CRC64;
     MRGTPGDADG GGRAIYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT
     CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY
     RVKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND
//
ID   G3RIS9_GORGO            Unreviewed;       160 AA.
AC   G3RIS9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000015591};
DE   Flags: Fragment;
GN   Name=IL36A {ECO:0000313|Ensembl:ENSGGOP00000015591};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000015591, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000015591, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000015591}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000015591}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSGGOT00000016039; ENSGGOP00000015591; ENSGGOG00000015991.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3RIS9; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001519; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSGGOP00000015591}.
SQ   SEQUENCE   160 AA;  17900 MW;  FC1C12A461D5F817 CRC64;
     TTMEKALKID TPQWGSIQDI NHRVWVLQDQ TLIAVPRKDR MSPVTIALIS CRHVETLETD
     RGNPIYLGLN GLNLCLMCAK VGDQPTLQLK EKDIMDLYNQ PEPVKSFLFY HSQSGRNSTF
     ESVAFPGWFI AVSSEGGCPL ILTQELGKAN TTDFGLTILF
//
ID   G3RVP4_GORGO            Unreviewed;       218 AA.
AC   G3RVP4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 31.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000019874};
GN   Name=101132267 {ECO:0000313|Ensembl:ENSGGOP00000019874};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000019874, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000019874, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000019874}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000019874}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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DR   RefSeq; XP_004031672.1; XM_004031624.1.
DR   RefSeq; XP_004031677.1; XM_004031629.1.
DR   Ensembl; ENSGGOT00000023990; ENSGGOP00000019874; ENSGGOG00000027015.
DR   Ensembl; ENSGGOT00000031337; ENSGGOP00000022923; ENSGGOG00000027212.
DR   GeneID; 101130935; -.
DR   GeneID; 101132267; -.
DR   KEGG; ggo:101130935; -.
DR   KEGG; ggo:101132267; -.
DR   CTD; 27178; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   KO; K05485; -.
DR   OMA; RKHTEFS; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001519; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   218 AA;  24166 MW;  66E58C310C9CECB5 CRC64;
     MSFVGENSGV KMGSEDWEKD EPQCCLEDPA GSPLEPGPSL PTMNFVHTSP KVKNLNPKKF
     SIHDQDHKVL VLDSGNLIAV PDKNYIRPEI FFALASSLSS ASAEKGSPIL LGVSKGEFCL
     YCDKDKGQSH PSLQLKKEKL MKLAAQKESA RRPFIFYRAQ VGSRNMLESA AHPGWFICTS
     CNCNEPVGVT DKFENRKHIE FSFQPVCKAE MSPREVSD
//
ID   G3S1V6_GORGO            Unreviewed;       157 AA.
AC   G3S1V6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000022052};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSGGOP00000022052};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000022052, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000022052, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000022052}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000022052}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_004031684.1; XM_004031636.1.
DR   Ensembl; ENSGGOT00000027597; ENSGGOP00000022052; ENSGGOG00000015995.
DR   GeneID; 101134640; -.
DR   KEGG; ggo:101134640; -.
DR   CTD; 27177; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   KO; K05486; -.
DR   OMA; FQSVSYP; -.
DR   Proteomes; UP000001519; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   157 AA;  17673 MW;  F2179BB9520CAE4E CRC64;
     MNPQREAAPK SYAIRDSQQM VWVLSGNSLI AAPLSRSVKP VTLHLIACRD TEFSDKEKAN
     MVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSV
     SYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVK
//
ID   G3SF34_GORGO            Unreviewed;       193 AA.
AC   G3SF34;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000026718};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSGGOP00000026718};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000026718, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000026718, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000026718}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000026718}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_004052172.1; XM_004052124.1.
DR   RefSeq; XP_004052173.1; XM_004052125.1.
DR   Ensembl; ENSGGOT00000034768; ENSGGOP00000026718; ENSGGOG00000015869.
DR   GeneID; 101138403; -.
DR   KEGG; ggo:101138403; -.
DR   CTD; 3606; -.
DR   GeneTree; ENSGT00390000001053; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000001519; Chromosome 11.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22327 MW;  B034C860037883BB CRC64;
     MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN LNDQVLFIDQ
     GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK
     EMDPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL
     GDRSIMFTVQ NED
//
ID   G3SN89_LOXAF            Unreviewed;       268 AA.
AC   G3SN89;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000001051};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSLAFP00000001051};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001051};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000001051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001051};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000001051}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001051};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000001051}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_003417445.1; XM_003417397.1.
DR   STRING; 9785.ENSLAFP00000001051; -.
DR   Ensembl; ENSLAFT00000001246; ENSLAFP00000001051; ENSLAFG00000001246.
DR   GeneID; 100675032; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; G3SN89; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30297 MW;  6979482C8AD4E63B CRC64;
     MAKVPDLFED LKDCYSENEE YSSNNDTLSL IQKSFYDANY GPLQEVCMDK FMSLSTSETS
     KIAKPAFKES VAVVSATGKI LKKRRLSLNQ PITDEDLEAI ANDPEEEIIE SKSAFSTFQN
     KVKYGFTKTI KSQCILNDIL AQSLIRDPTG PYLKAAALNN LDNAVKFDIG AYKPADGFNI
     PVTLRISKTR LFVSAQDEGE PLLLKEMPET PKVIIDETNL LFLWENHGIM HYFRSMAHPE
     LFIATKNEER VHLARGQPST IDFKIWDN
//
ID   G3STJ8_LOXAF            Unreviewed;       262 AA.
AC   G3STJ8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 36.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000003388};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSLAFP00000003388};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000003388};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000003388}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003388};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000003388}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003388};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000003388}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_003417444.1; XM_003417396.2.
DR   STRING; 9785.ENSLAFP00000003388; -.
DR   Ensembl; ENSLAFT00000004058; ENSLAFP00000003388; ENSLAFG00000004059.
DR   GeneID; 100674746; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; G3STJ8; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    100       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   262 AA;  29990 MW;  97643320853BB93E CRC64;
     MAAVPELFGD VRNYYSDNED DLFFEPDGPK QMKCCFQDLD LCSPGDGGIR LQISQQHYNK
     SFKQVVSVIV AVEKLKTILV PCSQSFLTNL FSFIFEEEPI NYDDAYECDA AVLSLNCRLR
     DIDQKCLVLS GPYELQALHL NEQDIDRQVV FSMTFVQGEI SQEKTPVALG LKGKNVYLSC
     MMNDGKPTLQ LETVDPKLYP KRRMEKRFVF NKLQVKDKLE FESAEYPNWY ISTSQVEEMP
     VFLGNTRGGQ DITDFTMEEI SS
//
ID   G3TDR9_LOXAF            Unreviewed;       156 AA.
AC   G3TDR9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000012345};
DE   Flags: Fragment;
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSLAFP00000012345};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012345};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000012345}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012345};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000012345}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012345};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000012345}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9785.ENSLAFP00000012345; -.
DR   Ensembl; ENSLAFT00000014746; ENSLAFP00000012345; ENSLAFG00000014745.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3TDR9; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSLAFP00000012345}.
SQ   SEQUENCE   156 AA;  17268 MW;  DE7CE94775A0CB33 CRC64;
     EMVLSGVLCF RMKDAALKVL YLHENQLLAG GLHAGKVIKG EEISVVPNRS LDTRLSPVIL
     GIQGGSRCLS CGTGQEPTLK LEPVNIMELY LSAQESKSFT FYRRDTGLTS SFESAAYPGW
     FLCTVPEADQ PLRLTKLPEY AGWDAPITDF YFQQCD
//
ID   G3TP50_LOXAF            Unreviewed;       152 AA.
AC   G3TP50;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000017122};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSLAFP00000017122};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017122};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000017122}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017122};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000017122}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017122};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000017122}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9785.ENSLAFP00000017122; -.
DR   Ensembl; ENSLAFT00000021884; ENSLAFP00000017122; ENSLAFG00000023032.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3TP50; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16847 MW;  9E5A884E5175DADA CRC64;
     MCSLPMARYY IIKDVDQKVL YVRDGQVLVG DSDAENCCAE KICILPNRAL DRTKVPILLG
     IHGGSRCLAC VETEEGPSLQ LEAVNIEDLY KGGEGATRFT FFQSSLGSAF RLEAAAWPGW
     FLCGPAESRQ PVRLAKESDS SARTEFYFEQ SR
//
ID   G3TQR6_LOXAF            Unreviewed;       148 AA.
AC   G3TQR6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000017917};
DE   Flags: Fragment;
GN   Name=IL36G {ECO:0000313|Ensembl:ENSLAFP00000017917};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017917};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000017917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017917};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000017917}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017917};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000017917}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   Ensembl; ENSLAFT00000022158; ENSLAFP00000017917; ENSLAFG00000022694.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3TQR6; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSLAFP00000017917}.
SQ   SEQUENCE   148 AA;  16454 MW;  DA63E66ED857977D CRC64;
     PQNGTILDLN HQVWVLQSQT LVAVPRSDSV VPVTVTLIPC KYPESFEQDK GTPIYMGIKN
     PEMCLSCEDV GGQPTLKLKV EKILDLYDQA APVKPFLFYH DKKGRTSTFE SVAFPGWFIA
     SSEIGQPIFL TSELGKAYNT EFDLSIKA
//
ID   G3TQV3_LOXAF            Unreviewed;       191 AA.
AC   G3TQV3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 21.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000017961};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSLAFP00000017961};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017961};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000017961}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017961};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000017961}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017961};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000017961}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9785.ENSLAFP00000022754; -.
DR   Ensembl; ENSLAFT00000036409; ENSLAFP00000017961; ENSLAFG00000028093.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   191 AA;  21898 MW;  D5A13E7782F1D9FF CRC64;
     MAAELVEDSC INFVEMKFIG NTLYFIRSLE SDHFGKLEPT KFAIIRNLNN QVLFIDQKNK
     PVFEDMPDSD CNDNAAQTVF IITMYKDSQP RRLAVTVSVK CSKRILTLSC ENKTANFKEM
     SPPEDINDTQ SDIIFFMKGV EGHDEKTQFE SSSYPGYFLA SERDADLYKL ILKEKNQIGD
     NSVMFTIDLQ E
//
ID   G3TRR2_LOXAF            Unreviewed;       175 AA.
AC   G3TRR2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000018270};
GN   Name=LOC100666284 {ECO:0000313|Ensembl:ENSLAFP00000018270};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000018270, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000018270}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018270};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000018270}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018270};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000018270}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_003417541.1; XM_003417493.2.
DR   STRING; 9785.ENSLAFP00000018270; -.
DR   Ensembl; ENSLAFT00000030095; ENSLAFP00000018270; ENSLAFG00000026075.
DR   GeneID; 100666284; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3TRR2; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    175       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003455829.
SQ   SEQUENCE   175 AA;  19805 MW;  B8A86A56A8C0A315 CRC64;
     MEIFRCPLSH LISLILLLFY SEAACGPTKR RLYKMQTFRI WDVNQKVFYL SNNQLVAGYL
     QAANAKLEEK IYVVLTESPG GMFLGIHEGK LWLACVKSGE KNTLQLEEVN ITDVGRNKEE
     AKRFAFTRSQ NGSITSFESA AYPGWFLCTE SEGDGPVSLT NEPGDTTRFY FHADQ
//
ID   G3U4J6_LOXAF            Unreviewed;       195 AA.
AC   G3U4J6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000022754};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSLAFP00000022754};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000022754};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000022754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022754};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000022754}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022754};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000022754}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9785.ENSLAFP00000022754; -.
DR   Ensembl; ENSLAFT00000026165; ENSLAFP00000022754; ENSLAFG00000028093.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; G3U4J6; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   195 AA;  22254 MW;  05A24880F510344F CRC64;
     MAAELVEDSC INFVEMKFIG NTLYFIPEND GSLESDHFGK LEPTKFAIIR NLNNQVLFID
     QKNKPVFEDM PDSDCNDNAA QTVFIITMYK DSQPRRLAVT VSVKCSKRIL TLSCENKTAN
     FKEMSPPEDI NDTQSDIIFF MKGVEGHDEK TQFESSSYPG YFLASERDAD LYKLILKEKN
     QIGDNSVMFT IDLQE
//
ID   G3U869_LOXAF            Unreviewed;       175 AA.
AC   G3U869;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000024027};
DE   Flags: Fragment;
GN   Name=LOC100675222 {ECO:0000313|Ensembl:ENSLAFP00000024027};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024027, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000024027}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024027};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000024027}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024027};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000024027}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9785.ENSLAFP00000024027; -.
DR   Ensembl; ENSLAFT00000031420; ENSLAFP00000024027; ENSLAFG00000028746.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3U869; -.
DR   OMA; KITQFYF; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    175       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003456433.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSLAFP00000024027}.
SQ   SEQUENCE   175 AA;  19698 MW;  18D69D60E716EF63 CRC64;
     FCRVPLSHLI SLILLFHSEA TGSPLQEKPY KMQTFRIWDV NQKVFYLSNN QLVAGYLQAA
     NAKLEEKIYV VLTESPGGMF LGIHEGKLWL ACVKSGEKNT LQLEEVNITD VGRNKEEAKR
     FAFIRSQNGS ITSFESAAYP GWFLCTESEG DGPVNLTNKP GDTTKITQFY FHADQ
//
ID   G3UL62_LOXAF            Unreviewed;       160 AA.
AC   G3UL62;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLAFP00000028571};
DE   Flags: Fragment;
GN   Name=IL36A {ECO:0000313|Ensembl:ENSLAFP00000028571};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028571};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000028571}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028571};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000028571}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028571};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000028571}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSLAFT00000027734; ENSLAFP00000028571; ENSLAFG00000032446.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3UL62; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSLAFP00000028571}.
SQ   SEQUENCE   160 AA;  18272 MW;  0DDC5FBB01388881 CRC64;
     RQKLKILSKA EPLLGNIQDI SHQVWFFQDQ TLTAVPRKNC MVPVTVTLIS CKCPETLEKD
     KGNPIYLGLK EPELCLFCEK VKDQPTLQLK EQNIMDLYYE NEPVKPFLFY HSQSGRTSTF
     ESVAFPGWFI AVCSQGGCPV IVTQDVGKTY ITDFVWSVLY
//
ID   G3W2K5_SARHA            Unreviewed;       261 AA.
AC   G3W2K5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000009660};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSSHAP00000009660};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009660, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000009660}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000009660}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000009660}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01035082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01035083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01035084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012395930.1; XM_012540476.1.
DR   STRING; 9305.ENSSHAP00000009660; -.
DR   Ensembl; ENSSHAT00000009745; ENSSHAP00000009660; ENSSHAG00000008360.
DR   GeneID; 105749132; -.
DR   KEGG; shr:105749132; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; G3W2K5; -.
DR   KO; K04383; -.
DR   OrthoDB; EOG76473H; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1     87       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   261 AA;  29483 MW;  DF7665103E69E4CB CRC64;
     MARVPDIYED LHLQYSDNEE FISDTHHVSS SQDSFYTNSS PYQEESCTKL EISEKIHQLN
     SQDCVDAPVV KKKKEKKKQI SESHPITSNY VFNVGSNLDK HKDVNRLMAA SKREYTFNSY
     LTNQTISDQD NRSILQIENH LRAVPIQAIT PDGVFDIGRY VTLQPAPNYG MAVTIRIANT
     QLFVAAKGEN EPVELQELPK TPTTLDSTSQ FLFYWKTEGN YSTFASLAYP GLFLATDVKD
     DELVFLAKGL PALTAFLVVD Q
//
ID   G3W4G1_SARHA            Unreviewed;       273 AA.
AC   G3W4G1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000010316};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSSHAP00000010316};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000010316, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000010316}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000010316}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000010316}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01035087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003758660.1; XM_003758612.2.
DR   STRING; 9305.ENSSHAP00000010316; -.
DR   Ensembl; ENSSHAT00000010406; ENSSHAP00000010316; ENSSHAG00000008907.
DR   GeneID; 100922350; -.
DR   KEGG; shr:100922350; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; G3W4G1; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    105       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   273 AA;  31828 MW;  300C523160BBC6F1 CRC64;
     MAMVPEITCE EMDFYRDNEH QFYESDGPNQ KKGNLQCLDL CPKESLLVED DIQLKFTAQP
     HQFYRTVVVV VAIEKMKHLN KICSQFFQDN DLMNIFTTIF QEEPIVIENC DMYESDFPFP
     FAFSRDYTIQ DINQKCLTLS NASELQALHL NGQNISQQVI FSMKYFLGEI GSQKTHVVLC
     IKKNNFYLSC VKRNGKPILQ LEQVANFPSN NPDRRFIFNK TEINHKTEFE SVEYPNWFIS
     TSQMDEQPVF LGNIRGGEDI TNFILEDLSE MNS
//
ID   G3W911_SARHA            Unreviewed;       177 AA.
AC   G3W911;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000011916};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000011916};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000011916}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000011916}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000011916}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01035099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSHAT00000012014; ENSSHAP00000011916; ENSSHAG00000010224.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3W911; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   177 AA;  19702 MW;  A7D756D666D8BBAA CRC64;
     MREGKQETPD YHQESQSVEY PSLGKIRDIH QQVWILQNGT LIATPHGENV NPVTLEVLPC
     RDESLPKDKG EPIYVGIKAS GCCLHCKMSG EQPILILVEK NLKDLYTTPE AVKPFLFYRN
     QTGITSTLES AAFPGWFICT SSNKNQPVTL THNLGGQCNT AFYLNIETPV LKTPIST
//
ID   G3W9W2_SARHA            Unreviewed;       160 AA.
AC   G3W9W2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000012217};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012217};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000012217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000012217}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000012217}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01035101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSHAT00000012316; ENSSHAP00000012217; ENSSHAG00000010472.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3W9W2; -.
DR   OMA; CCEESEG; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   160 AA;  18174 MW;  D6D0419AAEB5D6DB CRC64;
     MDSEKSKQLS RDIVSIIHLK DTNQQVLILQ DNILIASPHS DYVTPVTFAS LPCRDIENLA
     IDKGSPIYLG IDGKELCLCC EESEGEPTLK LKEKNVWKLY QSKDAEKPFV FYQDQNGSMS
     SLESAAYPGW FICTSSERNR PLRMTQQKEP NCNTSFYLSQ
//
ID   G3WA84_SARHA            Unreviewed;       154 AA.
AC   G3WA84;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000012339};
DE   Flags: Fragment;
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSSHAP00000012339};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012339, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000012339}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000012339}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000012339}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01035102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSHAT00000012439; ENSSHAP00000012339; ENSSHAG00000010571.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3WA84; -.
DR   OMA; FKLESAM; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSSHAP00000012339}.
SQ   SEQUENCE   154 AA;  18075 MW;  46B4F3763405953B CRC64;
     SPNLNKLLCF RMKDTARKSI YVQNDQLFAL SRHHDRLMKN DEISMVPSWN LDAKQFPIIL
     GIKRGYLCLS VGIDQQPFLQ IEEKNIMDLY HSKEESKNFT FYMRNPGVIF KLESAMYPGW
     FICSSLEDNK PITLTNHPEE VESVITDLYF QPCY
//
ID   G3WAG9_SARHA            Unreviewed;       152 AA.
AC   G3WAG9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000012424};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSSHAP00000012424};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012424, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000012424}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000012424}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000012424}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01035103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012395929.1; XM_012540475.1.
DR   STRING; 9305.ENSSHAP00000012424; -.
DR   Ensembl; ENSSHAT00000012526; ENSSHAP00000012424; ENSSHAG00000010640.
DR   GeneID; 100919996; -.
DR   KEGG; shr:100919996; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3WAG9; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  17204 MW;  5B9FC4780920C0DD CRC64;
     MCSLPMARYF VIKDAEQKPL CLKNDQFLVG DASSELCGAE RVCVLPNRFL DRNKFPIIMG
     IQNGTRCLAC VESGEGPLLQ LEDVNIEDLY KGGEETTRFT FFRSSSGPTF RLEAAAWPGW
     FLGAPTEPQE PVRLIKEDEP SPRTEFYFEQ SR
//
ID   G3WC28_SARHA            Unreviewed;       175 AA.
AC   G3WC28;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   08-JUN-2016, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000012983};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSSHAP00000012983};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012983, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000012983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000012983}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000012983}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01035104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003758665.1; XM_003758617.2.
DR   STRING; 9305.ENSSHAP00000012983; -.
DR   Ensembl; ENSSHAT00000013089; ENSSHAP00000012983; ENSSHAG00000011108.
DR   GeneID; 100923652; -.
DR   KEGG; shr:100923652; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; G3WC28; -.
DR   KO; K05481; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    175       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003458577.
SQ   SEQUENCE   175 AA;  19996 MW;  BEE17E7116DBB49A CRC64;
     MNLGVCLGAS LIAFLLFSFH SETASLPFKE MGSRKQTYRI WDVYQKIFYM RNKELVAGYL
     QGQNTNLEEK IDMISIEPHS VLLGIRDGTL CLACVKTGNT AHLRLEEVDI TDLDKDRNRS
     KRFTFIKTEN GSTSSFESAA CPGWFLCTQM EADRPVGLSN TQEENVITRF YFQRE
//
ID   G3WE02_SARHA            Unreviewed;       212 AA.
AC   G3WE02;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000013657};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000013657, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000013657}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000013657}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000013657}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01114794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSHAT00000013769; ENSSHAP00000013657; ENSSHAG00000011671.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; G3WE02; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   212 AA;  25273 MW;  48C8A2E1090260A1 CRC64;
     MAAAKDCQEV ACSPEENCKL NPNFIDNMEP EFREDECCLN CEAILKYSVP MCINLKNSNE
     KISFFNQEEE VVIFEEMMNN EKRENAPWTQ FMLQRYYCSG PRSLVAFSVK TENENYILSC
     KNHQELHFKY GDFPYEIEDK DEDILFWQSK VIGYEKVEFE SFLYPEHYLA WEKIQDKFEM
     LVLKEKLDGV EMSTIFTCIL CEKNENYEKC EK
//
ID   G3WEP2_SARHA            Unreviewed;       212 AA.
AC   G3WEP2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   08-JUN-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000013897};
GN   Name=LOC100919934 {ECO:0000313|Ensembl:ENSSHAP00000013897};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000013897};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000013897}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000013897}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000013897}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01114796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01114797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01114798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000013897; -.
DR   Ensembl; ENSSHAT00000014014; ENSSHAP00000013897; ENSSHAG00000011887.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; G3WEP2; -.
DR   OMA; CASEIDY; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   212 AA;  24278 MW;  4F5D611BEF0B22B8 CRC64;
     MATSANLPAA ACTTEMDFDQ DLNSINIVDL DFRNDTLYLM VEEQVKQEFS KLEKHCAILR
     NIKGRVLIIV KGEKMAVFEE MSDAEIKANA PRTQFIIQYY KETTPKGLAV ALSVKTEKKI
     YTLSCKNKKL HFKEGAAPDK IDGKEQDILF YQEKISGHDK KMQFKSVLYP EYYLACKQEK
     KGVFKLILKK GCQDTEGSTK FIVMYNCEKT DL
//
ID   G3WEP3_SARHA            Unreviewed;       204 AA.
AC   G3WEP3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000013898};
DE   Flags: Fragment;
GN   Name=LOC100919934 {ECO:0000313|Ensembl:ENSSHAP00000013898};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000013898};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000013898}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000013898}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000013898}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01114796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01114797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01114798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSHAT00000014015; ENSSHAP00000013898; ENSSHAG00000011887.
DR   GeneTree; ENSGT00390000001053; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSSHAP00000013898}.
SQ   SEQUENCE   204 AA;  23345 MW;  7CDE7FFD9F52F068 CRC64;
     KADAAQECCP GIPSSLSKRQ WFINTCHLVC DQEQSLVKQE FSKLEKHCAI LRNIKGRVLI
     IVKGEKMAVF EEMSDAEIKA NAPRTQFIIQ YYKETTPKGL AVALSVKTEK KIYTLSCKNK
     KLHFKEGAAP DKIDGKEQDI LFYQEKISGH DKKMQFKSVL YPEYYLACKQ EKKGVFKLIL
     KKGCQDTEGS TKFIVMYNCE KTDL
//
ID   G3WGN8_SARHA            Unreviewed;       201 AA.
AC   G3WGN8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-MAY-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000014593};
GN   Name=LOC100920716 {ECO:0000313|Ensembl:ENSSHAP00000014593};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000014593};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000014593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000014593}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000014593}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01114808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012400476.1; XM_012545022.1.
DR   STRING; 9305.ENSSHAP00000014593; -.
DR   Ensembl; ENSSHAT00000014715; ENSSHAP00000014593; ENSSHAG00000012457.
DR   GeneID; 100920716; -.
DR   KEGG; shr:100920716; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; G3WGN8; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   201 AA;  23069 MW;  19277B5C5ED11B8D CRC64;
     MAGEMYCDMD DNVFNLVDIE FRDGSLYFKA EDDDYLESDD FHKLEEPKHA ILRNVDNRVV
     MKKSGMDIAV LESMTDHEIQ ANASQTTFII QAYKETVPTA LAVAILVKNK NQIYSLSCQN
     KEVQFKEGAV PNYIAAARSD YIFYQKKVIG HNKMQFESSL YRGYFLACKK ERGYFKLVLK
     EGCEGVDELK MFSVHFCSVS I
//
ID   G5AQ60_HETGA            Unreviewed;       152 AA.
AC   G5AQ60;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   11-MAY-2016, entry version 16.
DE   SubName: Full=Interleukin-1 family member 6 {ECO:0000313|EMBL:EHA99170.1};
GN   ORFNames=GW7_14941 {ECO:0000313|EMBL:EHA99170.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA99170.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHA99170.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; JH166415; EHA99170.1; -; Genomic_DNA.
DR   InParanoid; G5AQ60; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  17360 MW;  FFC27B68E6E17F83 CRC64;
     MRIPFQRHIQ DFDQRVWVLQ GQTLTMVPRK ANVVPVTVDL YPCKHLETLE KGRGDPMYLG
     LKEPQFSLFC TKAGEQTVLQ LNKKKIKDLY DEPQPEKPFL FYHKEVGSTS TFESAAFSGW
     FIATGSNGEC PIFMTQEVGK THVTEFVLTT LS
//
ID   G5AQ61_HETGA            Unreviewed;       162 AA.
AC   G5AQ61;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   11-MAY-2016, entry version 17.
DE   SubName: Full=Interleukin-1 family member 9 {ECO:0000313|EMBL:EHA99171.1};
GN   ORFNames=GW7_14942 {ECO:0000313|EMBL:EHA99171.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA99171.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHA99171.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   EMBL; JH166415; EHA99171.1; -; Genomic_DNA.
DR   RefSeq; XP_004844796.1; XM_004844739.1.
DR   GeneID; 101725374; -.
DR   KEGG; hgl:101725374; -.
DR   CTD; 56300; -.
DR   InParanoid; G5AQ61; -.
DR   KO; K05487; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   162 AA;  18045 MW;  D88449956230914D CRC64;
     MANHVTPPTL ARDSSQLGKI PDLDQQAWIL QGQSLVTVPR SNSVVSVTVT VIPCKYTESL
     EQDKGTPIYL GIQNPDMCLC CENVEGQPTL VLKEKKILDL YNQPQPVKPF LFYRSHTGST
     STFESVAFPG WFIASSKKDD PIFLTSDQGK SYNINFNLYI EA
//
ID   G5B005_HETGA            Unreviewed;       270 AA.
AC   G5B005;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   11-MAY-2016, entry version 17.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|EMBL:EHB02616.1};
DE   Flags: Fragment;
GN   ORFNames=GW7_08922 {ECO:0000313|EMBL:EHB02616.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB02616.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB02616.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JH167710; EHB02616.1; -; Genomic_DNA.
DR   InParanoid; G5B005; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Cytokine {ECO:0000256|RuleBase:RU003753};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    111       IL1_propep. {ECO:0000259|Pfam:PF02394}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EHB02616.1}.
SQ   SEQUENCE   270 AA;  30551 MW;  2E74DA080CA477D7 CRC64;
     MAEIPNLFED LKSCYSENEE YASAIDHLSL NQKSFYDTSY GPLDKNCMNT SMSLRTLETS
     EASELTFKKN LVVVSTSAHG TVLKKRWLSL NQTITNEDLD AIANDPEEEI IKPQSAPHTL
     QSNVRYKYMR ILRKEFVLSD SIHQSITLDA TGQYLRAVAL TDLSQEAVKF DMGGYISATD
     DNTNPVTLRI SKTRLFVSAQ EEDQPMLLKE MPETPKIITG NELNLLFFWE NERGHNFFRS
     AANSELLIAT KEDSLVHMAR GSSSMTDFQI
//
ID   G5B006_HETGA            Unreviewed;       301 AA.
AC   G5B006;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:EHB02617.1};
GN   ORFNames=GW7_08923 {ECO:0000313|EMBL:EHB02617.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB02617.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB02617.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   EMBL; JH167710; EHB02617.1; -; Genomic_DNA.
DR   InParanoid; G5B006; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM      7     30       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       35    136       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   301 AA;  34640 MW;  3121133E2ABD0A4A CRC64;
     MPYRVPWVYV AIYITVTLAL SNLSAAISIV SEAAMAAVPE FSNEVTAYHS DENEMFFEVD
     GPKQMKHCFQ DLDLCSLDEG IELQISHQHF KKSFQQVVSL IVAVEKLRKE LVPCPWTFQD
     NDLRTFFPFI FEEEPIICDT WDDKYECDAP VLTRNCRLQD TQHKHLVLSD PCELKALHLN
     GENLNRQVVF SMSFVQGERR DDKIPVALGL KGKNLYLSCV MKDDKPVLQL ESVDPKQYPK
     KKMEKRFVFN KIDGKSTVEF ESAQYPNWYI STSQAEHMPV FLGNNHGGQD ITDFSMEFMS
     S
//
ID   G5B414_HETGA            Unreviewed;       162 AA.
AC   G5B414;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Interleukin-1 receptor antagonist protein {ECO:0000313|EMBL:EHB04025.1};
GN   ORFNames=GW7_01396 {ECO:0000313|EMBL:EHB04025.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04025.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB04025.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JH168381; EHB04025.1; -; Genomic_DNA.
DR   RefSeq; XP_004844593.1; XM_004844536.1.
DR   GeneID; 101706342; -.
DR   CTD; 3557; -.
DR   InParanoid; G5B414; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Receptor {ECO:0000313|EMBL:EHB04025.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   162 AA;  18548 MW;  7C7760E7E629A1E1 CRC64;
     MAAARLEAAC RPFGRRPYKM QSFRIWDINQ KTFYLRNNQL VAGYLQVPNT KLEEKIDMVP
     IDLHAVFLGI HKGKLCLSCV KSGDDISLQL EAVNITELSK NKEQNKRFTF IRSDSGPITS
     FQSAACPGWF LCTVVEADQP VRFTNNLEDS DMVTKFYFQE DQ
//
ID   G5B415_HETGA            Unreviewed;       164 AA.
AC   G5B415;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   11-MAY-2016, entry version 15.
DE   SubName: Full=Interleukin-1 family member 10 {ECO:0000313|EMBL:EHB04026.1};
GN   ORFNames=GW7_01397 {ECO:0000313|EMBL:EHB04026.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04026.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB04026.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JH168381; EHB04026.1; -; Genomic_DNA.
DR   InParanoid; G5B415; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   164 AA;  18440 MW;  144193DBB3BB7FA6 CRC64;
     MCSLPMARYY IIRDADQKVV YIRDNRLLVG DPDVDNCNAE KICILPNRGL DRTKVPIFLG
     IQGGNRCLAC VETREGPSLQ LEDVNIEDLY KGGEQATRFT FFQSSLGSAF RLEAAACPGW
     FLCGPDDPQQ PVRLSKQSES SAHTQFYFEQ SRDTLARILV IESE
//
ID   G5B416_HETGA            Unreviewed;       155 AA.
AC   G5B416;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Interleukin-1 family member 5 {ECO:0000313|EMBL:EHB04027.1};
GN   ORFNames=GW7_01398 {ECO:0000313|EMBL:EHB04027.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04027.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB04027.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; JH168381; EHB04027.1; -; Genomic_DNA.
DR   RefSeq; XP_004844590.1; XM_004844533.1.
DR   GeneID; 101705618; -.
DR   KEGG; hgl:101705618; -.
DR   CTD; 26525; -.
DR   InParanoid; G5B416; -.
DR   KO; K05483; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  17234 MW;  26A78C052379619E CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LYAGKVIKGE EISVVPNRWL DARLSPVILG
     VQGGSQCLSC GTGEEPTLKL EPVNIMELYL GTQESKRFTF YRQDLGLTSS FESATHPGWF
     LCTAPEADQP VRLSQIPKDS PWDTPIMDFY FQQCD
//
ID   G5BKU9_HETGA            Unreviewed;       137 AA.
AC   G5BKU9;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   11-MAY-2016, entry version 17.
DE   SubName: Full=Interleukin-1 family member 7 {ECO:0000313|EMBL:EHB09910.1};
GN   ORFNames=GW7_05225 {ECO:0000313|EMBL:EHB09910.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09910.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB09910.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; JH170786; EHB09910.1; -; Genomic_DNA.
DR   InParanoid; G5BKU9; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   137 AA;  15077 MW;  6B63F7DE2818D88E CRC64;
     MMSEATETFF ALPSHLKSTT VGKGDPILLA VSKGEFCLCC DKDKGKSQPS LHLKKKKLVK
     LADEKEAARK PFIFYNSKVG SLHTLESAAH LSFFCCTSCS SXXXXXXXEP IGVTDKVGKK
     KHIKSLFEKV CKPEMSQ
//
ID   G5CAZ3_HETGA            Unreviewed;       189 AA.
AC   G5CAZ3;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   11-MAY-2016, entry version 16.
DE   SubName: Full=Interleukin-18 {ECO:0000313|EMBL:EHB18704.1};
GN   ORFNames=GW7_04288 {ECO:0000313|EMBL:EHB18704.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB18704.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB18704.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; JH174262; EHB18704.1; -; Genomic_DNA.
DR   InParanoid; G5CAZ3; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   189 AA;  21843 MW;  D5D4D23934445598 CRC64;
     MAVSVSENDC INFVEMKFID NILYFIQNLE SDYFGKLVPK LSVIRNLKNQ VLIVDREKKP
     VFEDMPDADI ADNAPQTTFN KYTYTDSRGR GMAIVISVMC NGNHTLSCED KTISFKEINP
     PDNIIDTKSD IIFFQRRVPG HDDKMQFESS LYEGYFLACQ KEKDFYKLIL KKKDESGDKS
     IMFTVQNKD
//
ID   G7PMZ6_MACFA            Unreviewed;       271 AA.
AC   G7PMZ6;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   06-JUL-2016, entry version 23.
DE   SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:EHH55841.1};
GN   ORFNames=EGM_05124 {ECO:0000313|EMBL:EHH55841.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH55841.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH55841.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; CM001288; EHH55841.1; -; Genomic_DNA.
DR   UniGene; Mfa.6644; -.
DR   Proteomes; UP000009130; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   271 AA;  30702 MW;  0526AD7C40455290 CRC64;
     MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYDVSY GPLHEGCMDQ SVSLSISEIS
     KTSKLTFKQS MVVVSTNGKV LKKRRLSLSQ SITDNNLEAI ANDSEEEIIK PRSAPFSFLS
     NMTYHFIRII KHEFILNDTL NQTIIRANDQ YLTAAAIHNL DEAVKFDMGA YTSSKDDTKV
     PVILRISKTQ LYVSAQDEDQ PVLLKEMPEI PKTITGSETN FLFFWETHGT KNYFISVAHP
     NLFIATKHDN WVCLAKGLPS ITDFQILENQ A
//
ID   G7PMZ7_MACFA            Unreviewed;       268 AA.
AC   G7PMZ7;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   11-MAY-2016, entry version 18.
DE   SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:EHH55842.1};
GN   ORFNames=EGM_05125 {ECO:0000313|EMBL:EHH55842.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH55842.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH55842.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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CC   -----------------------------------------------------------------------
DR   EMBL; CM001288; EHH55842.1; -; Genomic_DNA.
DR   Proteomes; UP000009130; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30496 MW;  6E7D211C190C25F4 CRC64;
     MAEVPELASE MMAYYSGNED DLFFDVDGPK QMKCSFQDLD LCPLDGGIQL QISHEHYNEG
     FRQAVSVVVA MEKLRKMLVP CPQIFQDNDL STLIPFIFEE EPVFLDTRNN DAFVHDAPVR
     SLHCTLRDAQ LKSLVMSGPY ELKALHLQGQ DLEQQVVFSM SFVQGEESND KIPVALGLKA
     KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST
     SQAENMPVFL GGTRGGQDIT DFTMQFVS
//
ID   G7PMZ8_MACFA            Unreviewed;       218 AA.
AC   G7PMZ8;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   11-MAY-2016, entry version 13.
DE   SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:EHH55843.1};
GN   ORFNames=EGM_05126 {ECO:0000313|EMBL:EHH55843.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH55843.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH55843.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CM001288; EHH55843.1; -; Genomic_DNA.
DR   Proteomes; UP000009130; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   218 AA;  23979 MW;  8A7D6D752EAC5E98 CRC64;
     MSFVGENSGV KTGSEDWEKD EPQCYSENPA GSPLEPGPSL PSMNFVHTSP KVKNLNPKKF
     SIHDQDHKVL VVDSGNLIAV PDKNYIRPEI FFALASSLSS ASAEKGSPIL LGVSKGEFCL
     SCDKDKGQSH PSLQLKKKKL MKLAALKESA RRPFIFYRAQ VGSRNMLESA AHPGWFICTS
     CNCNEPVGVT DKFENRKHIE FSFQPVCKAE MSPSEVSD
//
ID   G7PMZ9_MACFA            Unreviewed;       168 AA.
AC   G7PMZ9;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   11-MAY-2016, entry version 13.
DE   SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:EHH55844.1};
GN   ORFNames=EGM_05127 {ECO:0000313|EMBL:EHH55844.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH55844.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH55844.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CM001288; EHH55844.1; -; Genomic_DNA.
DR   Proteomes; UP000009130; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   168 AA;  18626 MW;  65200841727938A9 CRC64;
     MRGTPGNPAG GGRVVYQSMR TPITGTINDL NQQVWTLQGQ ILVAVPRSDS VTPVTVAVIT
     CKYPEALDQS RGDPIYLGIR DPEMCLCCEE VGGQPTLQLK EQKIMDLYDQ PEPVKPFLFY
     RVKTGRTSTL ESVAFPNWFI ASSTRDQPII LTSELGKSYN TAFELNIK
//
ID   G7PN00_MACFA            Unreviewed;       158 AA.
AC   G7PN00;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   11-MAY-2016, entry version 15.
DE   SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:EHH55845.1};
DE   Flags: Fragment;
GN   ORFNames=EGM_05128 {ECO:0000313|EMBL:EHH55845.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH55845.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH55845.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CM001288; EHH55845.1; -; Genomic_DNA.
DR   Proteomes; UP000009130; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EHH55845.1}.
FT   NON_TER     158    158       {ECO:0000313|EMBL:EHH55845.1}.
SQ   SEQUENCE   158 AA;  17630 MW;  75215220F3E8D2E0 CRC64;
     FSTVSKSEMP QPVSIQDINH RVWVLQDQIL IAVPRKDRVS PVTISLISCR HVETLEKDRG
     NPIYLGLNGL NLCLMCAKAG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES
     VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF
//
ID   G7PN02_MACFA            Unreviewed;       155 AA.
AC   G7PN02;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   06-JUL-2016, entry version 22.
DE   SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:EHH55847.1};
GN   ORFNames=EGM_05130 {ECO:0000313|EMBL:EHH55847.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH55847.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH55847.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   EMBL; CM001288; EHH55847.1; -; Genomic_DNA.
DR   RefSeq; XP_005575359.1; XM_005575302.2.
DR   RefSeq; XP_015288886.1; XM_015433400.1.
DR   GeneID; 102124609; -.
DR   CTD; 26525; -.
DR   Proteomes; UP000009130; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  16934 MW;  F42B6E870D86668D CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
     VQGGSQCLSC GAGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF
     LCTVPEADQP VRLTQLPDNA GWNAPITDFY FQQCD
//
ID   G7PN03_MACFA            Unreviewed;       151 AA.
AC   G7PN03;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   11-MAY-2016, entry version 15.
DE   SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:EHH55848.1};
DE   Flags: Fragment;
GN   ORFNames=EGM_05131 {ECO:0000313|EMBL:EHH55848.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH55848.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH55848.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CM001288; EHH55848.1; -; Genomic_DNA.
DR   Proteomes; UP000009130; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER     151    151       {ECO:0000313|EMBL:EHH55848.1}.
SQ   SEQUENCE   151 AA;  16667 MW;  69C34BA3382FC85B CRC64;
     MCSLPMARYY IIKYADQKAL YMRDGQLLVG DPVADNCCAE KICILPNRGL DRTKVPIFLG
     IQGGSCCLAC VETGEGPSVQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAARTGW
     FLCGPAEPQQ PVQLTKESEP SARTEFYFEQ S
//
ID   G7PNT7_MACFA            Unreviewed;       193 AA.
AC   G7PNT7;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   11-MAY-2016, entry version 13.
DE   SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:EHH56756.1};
GN   ORFNames=EGM_06226 {ECO:0000313|EMBL:EHH56756.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH56756.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH56756.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CM001289; EHH56756.1; -; Genomic_DNA.
DR   Proteomes; UP000009130; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22265 MW;  B2126D03AFF1C4DF CRC64;
     MAAEPAEDNC INFVAMKFID STLYFIGKAN ENLESDYFGK LESKLSIIRN LNDQVLFIDQ
     GNRPLFEDMT DSDCRDNAPR TIFIINMYKD SQPRGMAVAI SVKCEKISTL SCENRIISFK
     EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLY KLILKKKDEL
     GDRSIMFTVQ NED
//
ID   G8JKV1_BOVIN            Unreviewed;       192 AA.
AC   G8JKV1;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   11-MAY-2016, entry version 23.
DE   SubName: Full=Interleukin-18 {ECO:0000313|Ensembl:ENSBTAP00000000344};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSBTAP00000000344};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000000344, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000000344, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000344,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000000344}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000344};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000000344}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02040288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02040289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02040290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9913.ENSBTAP00000055793; -.
DR   PaxDb; G8JKV1; -.
DR   Ensembl; ENSBTAT00000000344; ENSBTAP00000000344; ENSBTAG00000000277.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   ExpressionAtlas; G8JKV1; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   192 AA;  22259 MW;  800499DB78726713 CRC64;
     MAAEQVEDYC ISFVEMKFIN NTLYFVVQNE DLESDHFGKL EPKLSIIRNL NDQVLFINQG
     NQPVFEDMPD SDCSDNAPQT IFIIYMYKDS LTRGLAVTIS VQCKKMSTLS CENKIVSFKE
     MNPPDNIDNE ESDIIFFQRS VPGHDDKIQF ESSLYKGYFL ACKKENDLFK LILKKQDDNR
     DKSVMFTVQN QN
//
ID   H0VC55_CAVPO            Unreviewed;       152 AA.
AC   H0VC55;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000007505};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSCPOP00000007505};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007505};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000007505}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007505};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000007505}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007505};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000007505}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003465102.1; XM_003465054.1.
DR   STRING; 10141.ENSCPOP00000007505; -.
DR   Ensembl; ENSCPOT00000008423; ENSCPOP00000007505; ENSCPOG00000008348.
DR   GeneID; 100722140; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0VC55; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  17263 MW;  D5247BF1E5C34F61 CRC64;
     MCSLPMARYY IIRDLDQKVL YLRDDRLLVG DPDADNCNAE KICILPNRCL DRTKIPIFLG
     IQGGSRCLAC VETQEGPSLQ LEDVNIEDLY KGGEQVTRFT FFQSSLGSAF RLESAAYPGW
     FLCGPDEPQQ PVRLSKESEP SAHTQFYFEQ SR
//
ID   H0VCK4_CAVPO            Unreviewed;       157 AA.
AC   H0VCK4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000007668};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSCPOP00000007668};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007668};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000007668}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007668};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000007668}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007668};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000007668}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000007668; -.
DR   Ensembl; ENSCPOT00000008606; ENSCPOP00000007668; ENSCPOG00000008529.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0VCK4; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   157 AA;  17417 MW;  92561E6205E695D1 CRC64;
     KMVLSGALCF RMKDSALKVL YLHDNQLLAG GMHAGKVIKV GEEISVVPNR WLDARLCPVI
     LGVQGGSRCL SCGTGNEPTL KLEPVNIMEL YLGTQESKHF TFYRQELGLT SSFESAAYPG
     WFLCTAQEAD QPVKLSQIPK DSPWDAPITD FYFQQCD
//
ID   H0VCX7_CAVPO            Unreviewed;       176 AA.
AC   H0VCX7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   08-JUN-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000007810};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSCPOP00000007810};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007810};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000007810}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007810};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000007810}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007810};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000007810}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005001609.1; XM_005001552.2.
DR   STRING; 10141.ENSCPOP00000007810; -.
DR   Ensembl; ENSCPOT00000008778; ENSCPOP00000007810; ENSCPOG00000008700.
DR   GeneID; 100721865; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0VCX7; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    176       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003541806.
SQ   SEQUENCE   176 AA;  20289 MW;  9A9C9C21537C65EA CRC64;
     MEICKASYSL LFSLLFLFHS EAACRSLGRR PCKMQSFRIW DINQKTFYLR NNQLFAGHLQ
     MPNTKLEVKL DMVPVNAHNV FLGIHNGKLC LSCVKSGDDI RLQLEAVNIT DLSKNKEQNK
     RFTFIRLDNG STMSFQSAAC PGWFLCTVEE ADQPVRLTNN LQDSHTVTQF YFREDQ
//
ID   H0VNC3_CAVPO            Unreviewed;       154 AA.
AC   H0VNC3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 31.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000011942};
GN   Name=LOC100734697 {ECO:0000313|Ensembl:ENSCPOP00000011942};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000011942};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000011942}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000011942};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000011942}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000011942};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000011942}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000011942; -.
DR   Ensembl; ENSCPOT00000013394; ENSCPOP00000011942; ENSCPOG00000013266.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0VNC3; -.
DR   OMA; YAESAPN; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   154 AA;  17476 MW;  632F3FE4889C0E02 CRC64;
     LTARELPIYF NIRDSQQMVW VLSGNVLIAA PSSNDIKPVT LALVPCRQTE LSNKAEGNLV
     YLGIKDKNLS LFVETEEKPT LQLKEIKIMD LYWEDTLQKP FLFFHCKEGS TSAFQSVAYP
     GWFIATSSVP YQPVFLTQER GLTNDTNFYL DSTS
//
ID   H0VTR0_CAVPO            Unreviewed;       160 AA.
AC   H0VTR0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000014069};
GN   Name=IL36A {ECO:0000313|Ensembl:ENSCPOP00000014069};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000014069};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000014069}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014069};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000014069}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014069};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000014069}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000015754; ENSCPOP00000014069; ENSCPOG00000015601.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0VTR0; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   160 AA;  18289 MW;  8F8ED6CA30FF2E20 CRC64;
     LTFSTELSMA MPFHRHIQDL DHRVWVLQGH TLTMVPKRRN VVPVTVDLYP CQHLETLEKD
     RGNPMYLGLK ELQSSLFCTK VGEQPELQLN KRTIDNLYHH PQPEKPFLFY HNQAGNTSTF
     ESAAFPGWFI GTGSTGESPV FMTQEVGKTH VTEFVLTTMS
//
ID   H0VUT3_CAVPO            Unreviewed;       160 AA.
AC   H0VUT3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000014458};
GN   Name=Il36g {ECO:0000313|Ensembl:ENSCPOP00000014458};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000014458};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000014458}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014458};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000014458}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014458};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000014458}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000025686; ENSCPOP00000014458; ENSCPOG00000025104.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0VUT3; -.
DR   OMA; TITILTC; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   160 AA;  17952 MW;  CFB58207E6561C2E CRC64;
     IFVSIPVSSR DVPLLGKVSD LDQQVWILQG QSLVSVPRSN NVASVTITIL TCKYPESLEK
     GKGTPIYLEI QNPDMCLCCE KIEGQPTLLL KEQRILDLYN QPEPVKPFLF YHSHTGTTST
     FESVAFPDWF IASSKKDNPI FLTADLGKSY NTNFNLHMEA
//
ID   H0VWH2_CAVPO            Unreviewed;       150 AA.
AC   H0VWH2;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000015050};
GN   Name=LOC100712719 {ECO:0000313|Ensembl:ENSCPOP00000015050};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000015050};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000015050}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015050};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000015050}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015050};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000015050}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000015050; -.
DR   Ensembl; ENSCPOT00000025480; ENSCPOP00000015050; ENSCPOG00000026906.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0VWH2; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   150 AA;  17209 MW;  C19E92BD7148FCB4 CRC64;
     TPNHYDIRDT QQMVWILNGN VLVAVPSRNN VDPVTLSIIA CRDTQYCDKE KGNLIYLGIK
     DKNLSLYCTE IEGKPTLQLK EINIMNLYWE KTAQKPFLFF HSREGSTSAF QSVTYPGWFI
     ATSSVPNQPV FIIQERGLTN NTNFYLDPKN
//
ID   H0W0A7_CAVPO            Unreviewed;       163 AA.
AC   H0W0A7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000016392};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000016392};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000016392}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000016392};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000016392}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000016392};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000016392}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000016392; -.
DR   Ensembl; ENSCPOT00000023113; ENSCPOP00000016392; ENSCPOG00000023405.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0W0A7; -.
DR   OMA; GKEKNTH; -.
DR   OrthoDB; EOG7G4QHM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   163 AA;  18129 MW;  47C04F51DB67B2D6 CRC64;
     QLKSITSQKY CIRDTNQQVL VLQGSILVAA PDKLPKTGET FYVLVSTHTK IAEGNPIFLA
     VSKGELCLCC EKQKRSQHPI ACFKKTNIKE LNALGKKESL SFTFLKQEAG SYFTLESAAN
     RGYFIFTYNT PSQPVGVTKE IGKEKNTHFS FEAANVDLKE VKS
//
ID   H0W0J5_CAVPO            Unreviewed;       272 AA.
AC   H0W0J5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 30.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|Ensembl:ENSCPOP00000016482};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSCPOP00000016482};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000016482};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000016482}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000016482};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000016482}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000016482};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000016482}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003465104.1; XM_003465056.2.
DR   STRING; 10141.ENSCPOP00000016482; -.
DR   Ensembl; ENSCPOT00000027229; ENSCPOP00000016482; ENSCPOG00000026158.
DR   GeneID; 100135555; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; H0W0J5; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    114       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   272 AA;  31027 MW;  AE695E36424D1A85 CRC64;
     MAQCPNMLED LKSCYSENEE YASAIDHLSL NQKSFYDTNY DPLHENRVDK PVSPNPYENS
     EESNFTLEDS SDSSAVVLTS AHGEVLKKRR LSLNQTMSNE DLEAIANDSE EEIIEPWSVP
     YSFQSNLKFK YQRSIKKGAV ITDAMHQSLI RESNGQHLKA MHVVDRKHEV KFDIDGYVST
     ATRIRPVTLK ISKTQLYVCA QEEGQPVLLK EMPETPRVIT GNDVNLVFFW EIQRNHNFFR
     SAANTDLFIA TKMTGPVHMA KTLPSMLDFQ IS
//
ID   H0W1R8_CAVPO            Unreviewed;       203 AA.
AC   H0W1R8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|Ensembl:ENSCPOP00000016908};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSCPOP00000016908};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000016908};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000016908}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000016908};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000016908}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000016908};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000016908}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000016482; -.
DR   Ensembl; ENSCPOT00000025309; ENSCPOP00000016908; ENSCPOG00000026158.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    106       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   203 AA;  23128 MW;  EF26F4BF3B41D75F CRC64;
     EDLKSCYSEN EEYASAIDHL SLNQKSFYDT NYDPLHENRV DKPVSPNPYE NSEESNFTLE
     DSSDSSAVVL TSAHGEVLKK RRLSLNQTMS NEDLEAIAND SEEEIIEPWS VPYSFQSNLK
     FKYQRSIKKG AVITDAMHQS LIRESNGQHL KAMHVVDRKH EVKFDIDGYV STATRIRPVT
     LKISKTQLYV CAQEEGQPVL LKV
//
ID   H0W9Q2_CAVPO            Unreviewed;       150 AA.
AC   H0W9Q2;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 31.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000019712};
GN   Name=LOC100734419 {ECO:0000313|Ensembl:ENSCPOP00000019712};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000019712};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000019712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000019712};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000019712}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000019712};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000019712}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000019712; -.
DR   Ensembl; ENSCPOT00000020729; ENSCPOP00000019712; ENSCPOG00000023230.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0W9Q2; -.
DR   OMA; KEINIMD; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   150 AA;  17218 MW;  35F0C0A6FA653C73 CRC64;
     TPNHYDIRDT QQMVWILSGN TLVAVPSSNN VEPVTLAIIA CRDMEYRDEE KGNLVYLGIK
     DKNLSLYFTE TEGRPTLQLK EINIMDLYWE KTSQKPFLFF HSREGSTSAF QSVAYPGWFI
     ATSSVPNQPI FLTQERGLNN STNFYLDPKN
//
ID   H0WAP4_CAVPO            Unreviewed;       160 AA.
AC   H0WAP4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000020057};
GN   Name=LOC100735813 {ECO:0000313|Ensembl:ENSCPOP00000020057};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000020057};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000020057}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020057};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000020057}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020057};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000020057}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000025162; ENSCPOP00000020057; ENSCPOG00000024935.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0WAP4; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   160 AA;  17867 MW;  6D4E7F38FA246E45 CRC64;
     IFVSIQVSSR DAPLLGKVSD LDQQVWILQG QSLVSVPRSN DVASVTITVL TCKYPESLEK
     GKGTPIYLGI QNPDMCLCCE DIEGQPTLLL KEQRILDLYN QPEPVKPFLF YHSRTGTTST
     FESVAFPDWF IASSTKDNPI FLTADLGKSY NTNFNLRMEA
//
ID   H0WC40_CAVPO            Unreviewed;       196 AA.
AC   H0WC40;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000020559};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000020559};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000020559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020559};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000020559}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020559};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000020559}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02046993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000020559; -.
DR   Ensembl; ENSCPOT00000019929; ENSCPOP00000020559; ENSCPOG00000026714.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0WC40; -.
DR   OMA; LPFTFLK; -.
DR   OrthoDB; EOG7G4QHM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   196 AA;  21281 MW;  EE46E3956E536A0C CRC64;
     CCVSFPSSAR SPLLSNPSLA SVVSSKSGSQ LKSITSQKYC IRDTNQQVLV LQGSILVAAP
     DKLPKTGETF YVLASTHTKI AEGNPNFLAV SKEELCLCCE RVEEPNSPSL ELKKTNIKEL
     NALGKKESLP FTFLKQEAGS YFTLESAANR GYFIFTSNTP SQPVGVTKVM GKEKNIHFSF
     EAANVGLEVT EPQIKN
//
ID   H0WRY2_OTOGA            Unreviewed;       266 AA.
AC   H0WRY2;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000004813};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSOGAP00000004813};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004813, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000004813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000004813}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000004813}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03151658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03151659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000004813; -.
DR   Ensembl; ENSOGAT00000005383; ENSOGAP00000004813; ENSOGAG00000005382.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; H0WRY2; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    102       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   266 AA;  30275 MW;  F833B30669D4C2EA CRC64;
     MARVPDLFED YYSENEEHSS AFDQLCLNQK SFYDASHSSH NKDCVDQFMC LSACETSKGS
     GCTVQESVVL VTAKGKVLKK RRFNLDQSIT DDDLEAIPHD KKEVLAQPRS VPMNFTRNVK
     YRYMRILKSQ FILNDNLNQS IIRSSRQYLT TAALQNMDHA VKFDMGAYKS SAEDVTRPVI
     LRISKTQLYV STQDEDQPVL LKELPQIPRT IMGDDTNLLF FWETVGSRHY FTSVAHPTLY
     LATKQDNPVH LATGPPSSTD FLMLDA
//
ID   H0WRY4_OTOGA            Unreviewed;       268 AA.
AC   H0WRY4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000004815};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSOGAP00000004815};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004815, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000004815}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000004815}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000004815}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03151654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012666485.1; XM_012811031.1.
DR   STRING; 30611.ENSOGAP00000004815; -.
DR   Ensembl; ENSOGAT00000005385; ENSOGAP00000004815; ENSOGAG00000005383.
DR   GeneID; 100944877; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; H0WRY4; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30714 MW;  026F4F2EE75463E6 CRC64;
     MAAVPELTSE MMDYYSGNED DLFFEAEGSK QMKCSFQDLD LCPTDGGIQL HVSHQHYNKD
     FRQVVSLIVA MEKLRNKPVL CPKAFQDGDL STFFPFIFEE EPIFFDTCDD DWVCDGRVRS
     LNCTLRDAHQ KCLVMSGAYQ LKALHLQGQD LNHQVVFSMS FVQGDENSDK IPVALGLKEK
     NLYLSCVMKD EKPILQLESV DPKSYPKRKM EKRFVFNKIE TNNKVEFESA QFPNWYISTS
     QAQNMPVFLG KTKGGEDIVD FTMQFLSS
//
ID   H0WRY8_OTOGA            Unreviewed;       161 AA.
AC   H0WRY8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000004819};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSOGAP00000004819};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004819, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000004819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000004819}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000004819}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03151650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000004819; -.
DR   Ensembl; ENSOGAT00000005389; ENSOGAP00000004819; ENSOGAG00000005387.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0WRY8; -.
DR   OMA; RKHTEFS; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   161 AA;  18426 MW;  4D559BE8BE589C3E CRC64;
     PQQFSIEDQD HKVLILHCEN LMAVPNKNGV HAEIFFVLAS HLSSASEEKG GPILLAVSKG
     ERCLYCKKNK RQRKPTLVLK KKKLTKLATQ SEKARQPFIF YKARVGSRYT LESAAYPGWF
     VCTSYNAHEL VDMTEFGKRK YMEFDFIRIS ELPISPNEVS D
//
ID   H0X0H8_OTOGA            Unreviewed;       150 AA.
AC   H0X0H8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000008418};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSOGAP00000008418};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008418, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000008418}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000008418}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000008418}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03151638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03151639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000008418; -.
DR   Ensembl; ENSOGAT00000009403; ENSOGAP00000008418; ENSOGAG00000009401.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0X0H8; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   150 AA;  17110 MW;  C35DE6DF2EC36AAF CRC64;
     EKPTCYSIRD TLQMVWVLNG KSLITSPSTN NVKPVTLGIV TCRDTEFHNE EKGNMVYLEI
     KSKNLCLFCE EIQGKPTLQL KEKKIMELLE EKAQKPFLFF HNKEGSTSVF ESVAYPGWFI
     ATPPTAGQLV TLTQERDITT NTNFYLDLLN
//
ID   H0X0I0_OTOGA            Unreviewed;       155 AA.
AC   H0X0I0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000008420};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSOGAP00000008420};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008420, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000008420}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000008420}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000008420}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03151635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003799294.1; XM_003799246.2.
DR   STRING; 30611.ENSOGAP00000008420; -.
DR   Ensembl; ENSOGAT00000009407; ENSOGAP00000008420; ENSOGAG00000009404.
DR   GeneID; 100944244; -.
DR   CTD; 26525; -.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0X0I0; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  17017 MW;  64AD8133565A0092 CRC64;
     MVLSGALCFR MKDSALKVLY LNNNQLLAGG LHAGKVIKGE EINVVPNRWL DASLSPVILG
     VQGGSQCLSC GTGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDRGFTSS FESAAYPGWF
     LCTVPEADQP VSLIQLPENP NGDTFIVDFY FQQCD
//
ID   H0X0I1_OTOGA            Unreviewed;       152 AA.
AC   H0X0I1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000008422};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSOGAP00000008422};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008422, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000008422}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000008422}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000008422}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03151634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003799293.1; XM_003799245.1.
DR   STRING; 30611.ENSOGAP00000008422; -.
DR   Ensembl; ENSOGAT00000009410; ENSOGAP00000008422; ENSOGAG00000009409.
DR   GeneID; 100943921; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0X0I1; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16759 MW;  CCAD9362379F7ED8 CRC64;
     MCSLPMARYY IIKDADQKAL YMRDGQLFVG DPTADSCCAE KVCILPNRGL DRAKVPILLG
     VQGGSCCLAC VETGEGPSLK LEDVNIEDLY KGGEETTRFT FFQSSSGSAF RLEAAAWPGW
     FLCGPAEPQQ PVQLIKESEP SARTKFYFEQ SR
//
ID   H0X0I4_OTOGA            Unreviewed;       176 AA.
AC   H0X0I4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   08-JUN-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000008425};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSOGAP00000008425};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008425, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000008425}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000008425}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000008425}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03151628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003799340.1; XM_003799292.2.
DR   STRING; 30611.ENSOGAP00000008425; -.
DR   Ensembl; ENSOGAT00000009413; ENSOGAP00000008425; ENSOGAG00000009411.
DR   GeneID; 100960008; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0X0I4; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    176       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003544966.
SQ   SEQUENCE   176 AA;  20099 MW;  84F7F059AF77531A CRC64;
     MDISRGLCGH LISLLLFLFH SETACRPYGK RRCKMQAFRI WDINQKTFYL RNNQLVAGYL
     QGANTKLEEK LDVVSIKPHT MFLGIQRGKL CLSCVRVGEK TRLQLEAVNI TELSESRQQD
     KRFTFIRSDS GPTTTFESAA CPGWFLCTAL EADQPVTFTN TPEESAMVTK FYFQPD
//
ID   H0XG29_OTOGA            Unreviewed;       153 AA.
AC   H0XG29;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000015006};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSOGAP00000015006};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015006, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000015006}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000015006}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000015006}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03151645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOGAT00000016767; ENSOGAP00000015006; ENSOGAG00000016763.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0XG29; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   153 AA;  17025 MW;  FB48DAD158C1A37F CRC64;
     QKVATPVLGN ISDLSQQVWV LQGETLVVVP WSDGVVPVTV TVITCKYPEA LEQGKGDPIY
     LGIRNPEMCL FCEDAGGQPT LKLKEQKIME LYYQAEPVKP FLFYRVKTGR TSTFESVAFP
     GWFIASSKGK QPLFLTSDQG QSFNTAFDLK INE
//
ID   H0XG32_OTOGA            Unreviewed;       158 AA.
AC   H0XG32;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000015009};
GN   Name=IL36A {ECO:0000313|Ensembl:ENSOGAP00000015009};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015009, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000015009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000015009}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000015009}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03151641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOGAT00000016770; ENSOGAP00000015009; ENSOGAG00000016767.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H0XG32; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   158 AA;  18002 MW;  7DBC09E40204B721 CRC64;
     KSQKLVATYP QKGNIQDINH RVWVLQGQTL IAVPRKQHTV SVTVTFIACQ HQETLEKDRG
     NPIYLGLKEP ELCLFCTKVE EQPTLQLKEQ KIMDLYKEPQ PVKPFLFYHN QSGRNSTFES
     VVFPGWFIAV SSEGGFPVIL TQELGRANIA DFELTIQS
//
ID   H0XMK7_OTOGA            Unreviewed;       193 AA.
AC   H0XMK7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000017348};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSOGAP00000017348};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000017348, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000017348}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000017348}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000017348}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03115842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000017348; -.
DR   Ensembl; ENSOGAT00000032023; ENSOGAP00000017348; ENSOGAG00000029905.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; H0XMK7; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  21859 MW;  BCBC2D7C0CD14CA2 CRC64;
     MAADTVDNNC IDFVAMKFID NTLYFITEND ENLESDYFGK LEPKLSIIRN LNDQVLFIDQ
     GNKPVFEDMT DADCEANASQ TKLIINLYKD SFARGMAVTI SVNCKKIATL SCENKIISFK
     DISPPDSIKE PESDIIFFQT SVPGHDTKMQ FESSLYKGYF LACIKESDLF KLILKKNDEP
     GDKSILFTVQ NKD
//
ID   H0YPV3_TAEGU            Unreviewed;       194 AA.
AC   H0YPV3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   08-JUN-2016, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000000303};
DE   Flags: Fragment;
GN   Name=IL18 {ECO:0000313|Ensembl:ENSTGUP00000000303};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000000303, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000000303, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000000303}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTGUP00000000303}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABQF01045733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59729.ENSTGUP00000000303; -.
DR   Ensembl; ENSTGUT00000000308; ENSTGUP00000000303; ENSTGUG00000000297.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; H0YPV3; -.
DR   OMA; AFKFEYS; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Reactome; R-TGU-448706; Interleukin-1 processing.
DR   Reactome; R-TGU-449147; Signaling by Interleukins.
DR   Proteomes; UP000007754; Chromosome 24.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSTGUP00000000303}.
SQ   SEQUENCE   194 AA;  22282 MW;  4F00BAACF266AF88 CRC64;
     SRVKMSAEEI LVRAVELGKN FCLYFDDDDE LECDALCKER TLHRVLRNVN SQLLVVRPDL
     NVAAFEDVTD QEMQSGKGMH FSIHCYKTTT PLAGLPVAFS VQVEDKSYYM CCERECGEMI
     VRFKEGEVPK EIPGESNIIF FKKTFTSCSS KAFKFEYSME KGMFLAFEEE GCLRKLILKK
     LSKDEVDETM KMSL
//
ID   H0YYU7_TAEGU            Unreviewed;       269 AA.
AC   H0YYU7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   11-MAY-2016, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000003479};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSTGUP00000003479};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000003479, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000003479, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000003479}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTGUP00000003479}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABQF01056413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002195600.1; XM_002195564.3.
DR   STRING; 59729.ENSTGUP00000003479; -.
DR   Ensembl; ENSTGUT00000003515; ENSTGUP00000003479; ENSTGUG00000003368.
DR   GeneID; 100227014; -.
DR   KEGG; tgu:100227014; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; H0YYU7; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-TGU-446652; Interleukin-1 signaling.
DR   Reactome; R-TGU-448706; Interleukin-1 processing.
DR   Proteomes; UP000007754; Chromosome 22.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1     94       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   269 AA;  29793 MW;  082DC962C315DAC8 CRC64;
     MAFVPDLDTL ESSSLNEETF YGPNCLCPQK KPRLDLEGTS PGVGIQVTVT KGPLSRTFRQ
     AAVLVVAVTK LLKQPSRKDF ADSDLGSFLD DIFEPVSFRC IRGSYTRAPV FRYTRSQSFD
     ILDIDHKCFV LESPTQLVAL HLQGPSAGQK VKLNIALYRP RPSQGSPGSG RMPVALGIKG
     YQLYMSCVMS GTKPVLQLEE ADIRRDIESV ELTRFIFYRL DSPSEGTTRF ESAAFPGWFV
     CTSLQPRQPV GITNTPDQVN IATYELSGR
//
ID   H2L3F1_ORYLA            Unreviewed;       255 AA.
AC   H2L3F1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000000269};
GN   Name=LOC101169209 {ECO:0000313|Ensembl:ENSORLP00000000269};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000269, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000000269, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000269,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000000269}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000269};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000000269}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BAAF04115594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000000269; -.
DR   Ensembl; ENSORLT00000000269; ENSORLP00000000269; ENSORLG00000000217.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; H2L3F1; -.
DR   OMA; GWYISTA; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001038; Chromosome 9.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0042119; P:neutrophil activation; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:1901222; P:regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:Ensembl.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   255 AA;  28971 MW;  D39038800407AF0F CRC64;
     FAGRSFFSLN TTESEMACHK SDTYRMKMSH GLHLEISHHP HSMRSVVNLI IAIDRLKAGR
     MEEVMGTDFR DEHLLSVMLE SILEERHVAE RSSAPSQFSR TGEYQCSVTD KQKRSLVLVK
     NSMKLLAVML QGGSDSRKVQ LNMSTYLHRD RTPEARPVAL GIKDTKLYLS CHQEGDKPTL
     FLEEVEDNST LSTIGQESEN VRFLFYKQDT GGNLSTLASA RFPGWYISTA AIDSEPVEMC
     QESDSRFRTF HIRQS
//
ID   H2M2N2_ORYLA            Unreviewed;       192 AA.
AC   H2M2N2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000012678};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000012678, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000012678, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012678,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000012678}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012678};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000012678}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BAAF04027523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000012678; -.
DR   Ensembl; ENSORLT00000012679; ENSORLP00000012678; ENSORLG00000010112.
DR   eggNOG; ENOG410KGER; Eukaryota.
DR   eggNOG; ENOG4110SCG; LUCA.
DR   GeneTree; ENSGT00520000060257; -.
DR   InParanoid; H2M2N2; -.
DR   OMA; MATCEDS; -.
DR   OrthoDB; EOG7DZ8N6; -.
DR   Proteomes; UP000001038; Chromosome 13.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   192 AA;  22329 MW;  1CA9F0F7B651F6EA CRC64;
     IYPNGRFPCT IQHSGELDFP CSYFEGCEGD GFRISKCYQS NCWIQSKEQK FLILHNTGTL
     DVQDLNAEQR QHFLECRFNI QYYQNTSRDA TKKRPVILYA FKNGQTVAVC CHDEHTICSQ
     PMDLPNNICE TKHKALFYRT KVSTNLYMFE SSVYTSRFLA FEPLDNNPCI HKLVLRNKSE
     DEVDEPCQVI VS
//
ID   H2NFA9_PONAB            Unreviewed;       193 AA.
AC   H2NFA9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000004441};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSPPYP00000004441};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000004441, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000004441, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000004441}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000004441}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01320568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01320569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002822515.1; XM_002822469.2.
DR   STRING; 9601.ENSPPYP00000004441; -.
DR   Ensembl; ENSPPYT00000004616; ENSPPYP00000004441; ENSPPYG00000003877.
DR   GeneID; 100433564; -.
DR   KEGG; pon:100433564; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; H2NFA9; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22346 MW;  75028EE085099A38 CRC64;
     MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKFSIIRN LNDQVLFIDQ
     GNQPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK
     EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL
     GDRSIMFTVQ NED
//
ID   H2P5G1_PONAB            Unreviewed;       273 AA.
AC   H2P5G1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000013572};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSPPYP00000013572};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013572, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000013572, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000013572}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000013572}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01179053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01179054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01179055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002811834.1; XM_002811788.1.
DR   STRING; 9601.ENSPPYP00000013572; -.
DR   Ensembl; ENSPPYT00000014127; ENSPPYP00000013572; ENSPPYG00000012173.
DR   GeneID; 100454009; -.
DR   KEGG; pon:100454009; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; H2P5G1; -.
DR   KO; K04383; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001595; Chromosome 2a.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    111       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   273 AA;  30630 MW;  BB4F5CAAAE80C828 CRC64;
     MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFLSXXX XSYGPLHEGC MDQSVSLSIS
     ETSKHPGLLH ESMVVVATNG KVLKKRRLSL SQSITDDDLQ AIANGSEEEI IKPRSAPFSF
     LSNVKYNFMR IIKHEFILND ALNQSIIRAN DQYLTVAALH NLDEAVKFDM GAYKSSKDDA
     KITVILRISK TQLYVSAQDE DQPVLLKEMP EIPKTITGSE TNLLFFWETH GTKNYFTSVA
     HPNLFIATKQ DYWVCLAGGP PSITDFQILE NQA
//
ID   H2P5G2_PONAB            Unreviewed;       268 AA.
AC   H2P5G2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000013573};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSPPYP00000013573};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013573, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000013573, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000013573}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000013573}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01179059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002811835.1; XM_002811789.3.
DR   STRING; 9601.ENSPPYP00000013573; -.
DR   Ensembl; ENSPPYT00000014128; ENSPPYP00000013573; ENSPPYG00000012174.
DR   GeneID; 100454379; -.
DR   KEGG; pon:100454379; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; H2P5G2; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001595; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30625 MW;  9126A3E9C27B7F63 CRC64;
     MAEVPELASE MMAYYSGNED DLFFEVDGPK QMKCSFQDLD LCPLDGGIQL RISHQHYSKG
     FKQAVSVVVA MDKLRKMLVP CPQNFQDNDL STFFPFIFEE EPIFDTWDNE AYVHDAPVRS
     LNCTLRDAQQ KSLVMSGPYE LKALHLQGQD MEQQVVFSMS FVQGEESNDK IPVALGLKEK
     NLYLSCVLKD DKPTLQLESV DPKNYPKKKM EKRFVFNKIE INNKLEFESA QFPNWYISTS
     QAENMPVFLG GTKGGQDITD FTMQFVSS
//
ID   H2P5G3_PONAB            Unreviewed;       217 AA.
AC   H2P5G3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000013574};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSPPYP00000013574};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013574, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000013574, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000013574}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000013574}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01140491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000013574; -.
DR   Ensembl; ENSPPYT00000014129; ENSPPYP00000013574; ENSPPYG00000012175.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2P5G3; -.
DR   OMA; RKHTEFS; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001595; Chromosome 2a.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   217 AA;  23892 MW;  ED348255830FFC47 CRC64;
     MSFVGENSGV KMGSEDWEKD EPQCCLEDLA GSPLEPGPSL PAMNFVHTSP KVKNLNPKKF
     SIHDQDHKVL VLDSGNLIAV PDKNYICPEI FFALASSLSS ASVEKGSPIL LGVSEGFCLY
     CDKDKGQSHP SLQLKKKKLM KLAAEKESAR RPFIFYRAQV GSRNMLESAA HPGWFICTSC
     NCNEPVGVTD KRENRKHVEF SFQPVCKAEV SPSEVSD
//
ID   H2P5G4_PONAB            Unreviewed;       151 AA.
AC   H2P5G4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000013575};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSPPYP00000013575};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013575, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000013575, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000013575}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000013575}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01140485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01140486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPPYT00000014130; ENSPPYP00000013575; ENSPPYG00000012176.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2P5G4; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001595; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   151 AA;  16651 MW;  253B90160297B055 CRC64;
     MRGTPGDSAG GGKAVYQSMY KPITGTINDL NQQVWTLQGQ ILVAVPRSDS VIPVTVTVIT
     CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGGQPTLQLK EQKIMDLYGQ PEPVKPFLFY
     RVTGRTSTLE SVAFPDWFIV SSTHQPIILT S
//
ID   H2P5G5_PONAB            Unreviewed;       155 AA.
AC   H2P5G5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   06-JUL-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000013576};
GN   Name=IL36A {ECO:0000313|Ensembl:ENSPPYP00000013576};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013576, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000013576, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000013576}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000013576}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01006754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01006755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01140482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPPYT00000014131; ENSPPYP00000013576; ENSPPYG00000012177.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2P5G5; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001595; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  17267 MW;  C227BF72ECBD53A5 CRC64;
     ALKIDTPQRG SIQDINHRVW VLQDQTLIAV PRKDRMSPVT IALISCRHVE TLEKDRGNPI
     YLGLNGLNLC LTCAKVGDQP TLQLTEKDIM DLYNQPEPVK SFLFYHSQSG RNSTFESVAF
     PGWFIAVSSE GGCPLILTQE LGKANTTDFG LTMLF
//
ID   H2P5G6_PONAB            Unreviewed;       157 AA.
AC   H2P5G6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000013577};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSPPYP00000013577};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013577, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000013577, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000013577}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000013577}.
CC   -----------------------------------------------------------------------
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DR   EMBL; ABGA01235290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01235291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_009235361.1; XM_009237086.1.
DR   Ensembl; ENSPPYT00000014132; ENSPPYP00000013577; ENSPPYG00000012178.
DR   GeneID; 100457281; -.
DR   KEGG; pon:100457281; -.
DR   CTD; 27177; -.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2P5G6; -.
DR   KO; K05486; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001595; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   157 AA;  17673 MW;  72DF87D4A231FB9E CRC64;
     MNLQQEAAPK SYAIRDSRQM VWVLSGNSLI AAPLSHSVKP VTLHLIPCRD TEFSDKEKGN
     MVYLGIKGKD LCLFCAEIQG KPTLQLKEKN VMDLYMEKKA QKPFLFFHSK EASTSVFQSV
     SYPGWFIATS STSGQPIFLT QERGITNNTN FYLDSVK
//
ID   H2P5G7_PONAB            Unreviewed;       155 AA.
AC   H2P5G7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000013578};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSPPYP00000013578};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013578, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000013578, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000013578}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000013578}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01235297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002811839.1; XM_002811793.1.
DR   RefSeq; XP_003775918.1; XM_003775870.2.
DR   RefSeq; XP_009235362.1; XM_009237087.1.
DR   Ensembl; ENSPPYT00000014133; ENSPPYP00000013578; ENSPPYG00000012179.
DR   GeneID; 100457649; -.
DR   KEGG; pon:100457649; -.
DR   CTD; 26525; -.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2P5G7; -.
DR   KO; K05483; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001595; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  16962 MW;  F42AB5F6CB5D0AFD CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
     VQGGSQCLSC GAGQEPTLTL EPVNIMELYL GAKESKSFTF YRREMGLTSS FESAAYPGWF
     LCTVPEADQP VRLTQLPENA GWNAPITDFY FQQCD
//
ID   H2P5G8_PONAB            Unreviewed;       152 AA.
AC   H2P5G8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 21.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000013579};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSPPYP00000013579};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013579, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000013579, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000013579}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000013579}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01235297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002811842.1; XM_002811796.1.
DR   STRING; 9601.ENSPPYP00000013579; -.
DR   Ensembl; ENSPPYT00000014134; ENSPPYP00000013579; ENSPPYG00000012180.
DR   GeneID; 100458246; -.
DR   KEGG; pon:100458246; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2P5G8; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001595; Chromosome 2a.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  17036 MW;  5FD245CDC8431D85 CRC64;
     MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICILPNRGL YRTKVPIFLG
     LQGGSRCLAC VETEEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAAWPGW
     FLCGPAEPQQ PVQLTKESEP SARTEFYFEQ SW
//
ID   H2P5G9_PONAB            Unreviewed;       159 AA.
AC   H2P5G9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000013580};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSPPYP00000013580};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013580, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000013580, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000013580}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000013580}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01216364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01235300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01235301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000013580; -.
DR   Ensembl; ENSPPYT00000014135; ENSPPYP00000013580; ENSPPYG00000012181.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2P5G9; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001595; Chromosome 2a.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   159 AA;  17871 MW;  9A2EC8746470E3F8 CRC64;
     MALETVCRPS GRKSSKMQAF RIWDVNQKTF YLRNNQLVAG YLQGPNVNLE EKIDVVPIKP
     HALFLGIHGG KMCLSCVKSG DETRLQLEAV NITDLSENRK QDKRFTFIRS DSGPTTSFES
     AACPGWFLCT AMEADQPVSL TNMPDEGVVV TKFYFQEDE
//
ID   H2Q4S4_PANTR            Unreviewed;       193 AA.
AC   H2Q4S4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000007359};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSPTRP00000007359};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000007359, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000007359, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000007359}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000007359}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACZ03080544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001146844.1; XM_001146844.4.
DR   RefSeq; XP_003952084.1; XM_003952035.2.
DR   ProteinModelPortal; H2Q4S4; -.
DR   SMR; H2Q4S4; 37-193.
DR   STRING; 9598.ENSPTRP00000007359; -.
DR   PaxDb; H2Q4S4; -.
DR   PRIDE; H2Q4S4; -.
DR   Ensembl; ENSPTRT00000007973; ENSPTRP00000007359; ENSPTRG00000004284.
DR   GeneID; 739011; -.
DR   KEGG; ptr:739011; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; H2Q4S4; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000002277; Chromosome 11.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22326 MW;  323C62C203788D55 CRC64;
     MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN LNDQVLFIDQ
     GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK
     EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL
     GDRSIMFTVQ NED
//
ID   H2QIK5_PANTR            Unreviewed;       271 AA.
AC   H2QIK5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   06-JUL-2016, entry version 40.
DE   SubName: Full=Interleukin 1, alpha {ECO:0000313|EMBL:JAA03019.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000021189};
GN   Name=IL1A {ECO:0000313|EMBL:JAA03019.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000021189};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000021189, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000021189, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000021189}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:JAA03019.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03019.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from
RT   NextGen mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; AACZ03015786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01008319; JAA03019.1; -; mRNA.
DR   RefSeq; XP_525866.1; XM_525866.2.
DR   STRING; 9598.ENSPTRP00000021189; -.
DR   Ensembl; ENSPTRT00000022969; ENSPTRP00000021189; ENSPTRG00000012371.
DR   GeneID; 470485; -.
DR   KEGG; ptr:470485; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   KO; K04383; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002277; Chromosome 2A.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   271 AA;  30607 MW;  CBCCC49569D9ED40 CRC64;
     MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ SVSLSISETS
     KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI ANDSEEEIIK PRSAPFSFLS
     NVKYNFMRII KYEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI
     TVILRISKTQ LYVTAQDEDQ PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP
     NLFIATKQDY WVCLAGGPPS ITDFQILENQ A
//
ID   H2QIK6_PANTR            Unreviewed;       269 AA.
AC   H2QIK6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-JUN-2016, entry version 33.
DE   SubName: Full=Interleukin 1, beta {ECO:0000313|EMBL:JAA01071.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000021191};
GN   Name=IL1B {ECO:0000313|EMBL:JAA01071.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000021191};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000021191, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000021191, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000021191}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:JAA01071.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA01071.1},
RC   Skeletal muscle {ECO:0000313|EMBL:JAA37246.1}, and
RC   Smooth vascular {ECO:0000313|EMBL:JAA11977.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from
RT   NextGen mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACZ03015783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01010267; JAA01071.1; -; mRNA.
DR   EMBL; GABF01010168; JAA11977.1; -; mRNA.
DR   EMBL; GABE01007493; JAA37246.1; -; mRNA.
DR   RefSeq; XP_001147075.1; XM_001147075.4.
DR   UniGene; Ptr.6623; -.
DR   STRING; 9598.ENSPTRP00000021191; -.
DR   Ensembl; ENSPTRT00000022971; ENSPTRP00000021191; ENSPTRG00000012372.
DR   GeneID; 450200; -.
DR   KEGG; ptr:450200; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002277; Chromosome 2A.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   269 AA;  30790 MW;  06A1E270D4082DE9 CRC64;
     MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG
     FRQAVSVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWEN EAYVHDAPVR
     SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE
     KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST
     SQAENMPVFL GGTKGGQDIT DFTMQFVSS
//
ID   H2QIK7_PANTR            Unreviewed;       169 AA.
AC   H2QIK7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000021193};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSPTRP00000021193};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000021193, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000021193, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000021193}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000021193}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACZ03015776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03015777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001147221.1; XM_001147221.3.
DR   PaxDb; H2QIK7; -.
DR   Ensembl; ENSPTRT00000022973; ENSPTRP00000021193; ENSPTRG00000012374.
DR   GeneID; 738914; -.
DR   KEGG; ptr:738914; -.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2QIK7; -.
DR   KO; K05487; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002277; Chromosome 2A.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   169 AA;  18769 MW;  EB10269ABA0EAE5A CRC64;
     MRGTPGDADG GGRAIYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT
     CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY
     RAKTGRTSTF ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND
//
ID   H2QIK8_PANTR            Unreviewed;       158 AA.
AC   H2QIK8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-JUN-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000021194};
GN   Name=IL36A {ECO:0000313|Ensembl:ENSPTRP00000021194};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000021194, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000021194, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000021194}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000021194}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACZ03015776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_525867.2; XM_525867.4.
DR   ProteinModelPortal; H2QIK8; -.
DR   PaxDb; H2QIK8; -.
DR   Ensembl; ENSPTRT00000022974; ENSPTRP00000021194; ENSPTRG00000012375.
DR   GeneID; 470486; -.
DR   KEGG; ptr:470486; -.
DR   CTD; 27179; -.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2QIK8; -.
DR   KO; K05484; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002277; Chromosome 2A.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   158 AA;  17712 MW;  45AAFA1EA7DD7280 CRC64;
     MEKALKIDTP QRGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG
     NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES
     VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF
//
ID   H2QIK9_PANTR            Unreviewed;       155 AA.
AC   H2QIK9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-JUN-2016, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000021196};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSPTRP00000021196};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000021196, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000021196, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000021196}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000021196}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACZ03015776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; H2QIK9; -.
DR   Ensembl; ENSPTRT00000022976; ENSPTRP00000021196; ENSPTRG00000012376.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2QIK9; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002277; Chromosome 2A.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  16964 MW;  2E0AB5E60D86668A CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
     VQGGSQCLSC GAGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESATYPGWF
     LCTVPEADQP VRLTQLPENG GWNAPITDFY FQQCD
//
ID   H2QIL0_PANTR            Unreviewed;       152 AA.
AC   H2QIL0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-JUN-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000021198};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSPTRP00000021198};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000021198, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000021198, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000021198}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000021198}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACZ03015774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03015775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_525868.3; XM_525868.3.
DR   STRING; 9598.ENSPTRP00000021198; -.
DR   PaxDb; H2QIL0; -.
DR   Ensembl; ENSPTRT00000022978; ENSPTRP00000021198; ENSPTRG00000012377.
DR   GeneID; 470487; -.
DR   KEGG; ptr:470487; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2QIL0; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002277; Chromosome 2A.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16943 MW;  E5203C2FF98DB338 CRC64;
     MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICILPNRGL DRTKVPIFLG
     IQGGSRCLAC VDTEEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAARPGW
     FLCGPAEPQQ PVQLTKESEP SARTKFYFEQ SW
//
ID   H2QIL1_PANTR            Unreviewed;       180 AA.
AC   H2QIL1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-JUN-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000021201};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSPTRP00000021201};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000021201, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000021201, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000021201}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000021201}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACZ03015771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000021201; -.
DR   PaxDb; H2QIL1; -.
DR   Ensembl; ENSPTRT00000022981; ENSPTRP00000021201; ENSPTRG00000012378.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H2QIL1; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002277; Chromosome 2A.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   180 AA;  19913 MW;  EF69CCBEA3C6F237 CRC64;
     MALADLYEEG GGGGGEGEDN ADSKETVCRP SGRKSSKMQA FRIWDVNQKT FYLRNNQLVA
     GYLQGPNVNL EEKIDVVPIE PHALFLGIHG GKMCLSCVKS GDETRLQLEA VNITDLSENR
     KQDKRFTFIR SDSGPTTSFE SAACPGWFLC TAMEADQPVS LTNMPDEGVM VTKFYFQEDE
//
ID   H2U3M4_TAKRU            Unreviewed;       185 AA.
AC   H2U3M4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000031535};
GN   Name=il-18 {ECO:0000313|Ensembl:ENSTRUP00000031535};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000031535, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000031535}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSTRUP00000031535};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000031535}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000031535}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 31033.ENSTRUP00000031535; -.
DR   Ensembl; ENSTRUT00000031658; ENSTRUP00000031535; ENSTRUG00000012448.
DR   eggNOG; ENOG410KGER; Eukaryota.
DR   eggNOG; ENOG4110SCG; LUCA.
DR   GeneTree; ENSGT00520000060257; -.
DR   InParanoid; H2U3M4; -.
DR   OMA; MATCEDS; -.
DR   OrthoDB; EOG7DZ8N6; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000005226; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   185 AA;  21641 MW;  CEF6A5B071A7FEFA CRC64;
     MAANNSNFVT FLHATETAFY FEELDKDGFL YKSDFQKWIK SKDNKFLILN ESAEFQCQNL
     SIQEQEYYPE NKPHVCVYKN SDKMGKMGVI LYTCKDQKKV VLCCSDKLEI HPVEMDISHD
     IAEKAHKALF YLERITEGCY LLESSLYPSM FLAFEPDSNN QTLNKVILRH KEYDEVDETC
     HVIMS
//
ID   H2UVE2_TAKRU            Unreviewed;       263 AA.
AC   H2UVE2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000040919};
GN   Name=il1b {ECO:0000313|Ensembl:ENSTRUP00000040919};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000040919, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000040919}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000040919}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000040919}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 31033.ENSTRUP00000040919; -.
DR   Ensembl; ENSTRUT00000041061; ENSTRUP00000040919; ENSTRUG00000016002.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; H2UVE2; -.
DR   OMA; GWYISTA; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005226; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0042119; P:neutrophil activation; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:1901222; P:regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:Ensembl.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        8     76       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   263 AA;  29829 MW;  0D9BA1AD9466E842 CRC64;
     MESQMKSNES KMLQSQMPEG LELEITHHPL TMKSVVNLVI AMERLKGNRS ESLLSTEFRD
     ENLLSMMMDT IVEEQIVFER YSAPPVQKYM RMSMQEYSVS DSEKRSLIRV PDSMELNAVM
     LQGGSECRKV NLNLSTYVHL ESSINAQTVA LGIRGTNFFL SCHKDGEEPT LHLEAVEDKE
     QLSSISSDSE LVRFLFNKHI TGINLCTLVS VPYSDWYIST AVEENKPVEM CLESAQRNTI
     FTLLALKKTP TCEGEIVWCL NGE
//
ID   H2UVE3_TAKRU            Unreviewed;       257 AA.
AC   H2UVE3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   11-MAY-2016, entry version 21.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000040920};
GN   Name=il1b {ECO:0000313|Ensembl:ENSTRUP00000040920};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000040920, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000040920}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000040920}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000040920}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 31033.ENSTRUP00000040919; -.
DR   Ensembl; ENSTRUT00000041062; ENSTRUP00000040920; ENSTRUG00000016002.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   Proteomes; UP000005226; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        8     76       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   257 AA;  29158 MW;  B3557E34F4359F6B CRC64;
     MESQMKSNES KMLQSQMPEG LELEITHHPL TMKSVVNLVI AMERLKGNRS ESLLSTEFRD
     ENLLSMMMDT IVEEQIVFER YSAPPVQKYM RMSMQEYSVS DSEKRSLIRV PDSMELNAVM
     LQGGSECRKV NLNLSTYVHL ESSINAQTVA LGIRGTNFFL SCHKDGEEPT LHLEAVEDKE
     QLSSISSDSE LVRFLFNKHI TGINLCTLVS VPYSDWYIST AVEENKPVEM CLESAQRNTI
     FTLLALKKTP TCEEGPF
//
ID   H2V377_TAKRU            Unreviewed;       171 AA.
AC   H2V377;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-JUN-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000043658};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043658, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000043658}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000043658}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000043658}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSTRUT00000043804; ENSTRUP00000043658; ENSTRUG00000017041.
DR   eggNOG; ENOG410JGPV; Eukaryota.
DR   eggNOG; ENOG410YT8P; LUCA.
DR   GeneTree; ENSGT00390000016316; -.
DR   InParanoid; H2V377; -.
DR   OMA; ASHYYLS; -.
DR   OrthoDB; EOG7M6D88; -.
DR   Proteomes; UP000005226; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   171 AA;  19597 MW;  D95DE8B68D5798BC CRC64;
     LVAQSSKVML VARGSESFKQ ENSSNVMIEH VASHYYLSSL CSQKAISTSP DPERITIYRY
     KANEEEGEFS GMPVVLNFTE SNCFLRCCKK DDSVFLQVEA CDKGRLRQIS KSDKSTLSFV
     FYMKADRSNQ RTFESALHRG WFIQVVQTDV VEMSHLEAET DEYSFLFVIK K
//
ID   H3B449_LATCH            Unreviewed;       325 AA.
AC   H3B449;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   11-MAY-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000016670};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016670, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000016670}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000016670}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLACP00000016670}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AFYH01088322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01088323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01088324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLACT00000016785; ENSLACP00000016670; ENSLACG00000014685.
DR   eggNOG; ENOG410JGPV; Eukaryota.
DR   eggNOG; ENOG410YT8P; LUCA.
DR   GeneTree; ENSGT00390000016316; -.
DR   InParanoid; H3B449; -.
DR   OMA; ITIYYYK; -.
DR   OrthoDB; EOG7M6D88; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   325 AA;  36977 MW;  93A8A1BE98B80379 CRC64;
     KGDKILQVNE VSVENIQPEV LANLLCQTAF LTIHRPAKNP IVYTHHHKLM YQPYDKEHGL
     LEFSFTMVRK DNDSETWEMP GSSKSGNLVP LVPDTKMKDG LKECEEESML VVKLTQPSFS
     IVKGRGAQRS PGTTCMTCQK KDCDLHNVAV MSSTSLQTLT TKSGGNNFDN TVNYVPNSFI
     HHYYVLTLYL LMLTGRPLRS LPYSSLGATS SYMTIYHYKS CPVENTFSGM PVVLNFTNTN
     CYLACVEENG NVILKIEDCS AESLRNISES SPFWHFVFYM KTSKDRNCRF ESAKFKQWYI
     DSKYKPEVEM TRNSDDGSFY FLVSP
//
ID   H3BVV5_TETNG            Unreviewed;       257 AA.
AC   H3BVV5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000000117};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000000117, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000000117}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000000117}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000000117}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 99883.ENSTNIP00000000117; -.
DR   Ensembl; ENSTNIT00000003761; ENSTNIP00000000117; ENSTNIG00000001101.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; H3BVV5; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0042119; P:neutrophil activation; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:1901222; P:regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:Ensembl.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   257 AA;  29027 MW;  C03B8919BB8BC2E6 CRC64;
     MESQMSNNGK MLKSKMPEGL DLEISHHPLT MKSVVNLIIA LDRMKSISSS ESLLSTEFRD
     ENLLNIMLET VVEEKIVLEC YSAPPPQDKY SRRSEISCSV TDSEKRSLVR VPNSMELQAV
     MLQGGSECRK VNLTMSTYLE LQSNREAQTV TLAIRNTNFY LSCHKDGDEP TLHLEAVEDK
     EQLKSISSDS DMVRFLFYKH DSGVNLCTLV SVPYSDWYIS TAVEDNKPVE MCLESAQRYT
     SFTIQPLKGN PSCEGEM
//
ID   H3BZ69_TETNG            Unreviewed;       185 AA.
AC   H3BZ69;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   11-MAY-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000001285};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000001285, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000001285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000001285}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000001285}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSTNIT00000001978; ENSTNIP00000001285; ENSTNIG00000000265.
DR   eggNOG; ENOG410KGER; Eukaryota.
DR   eggNOG; ENOG4110SCG; LUCA.
DR   GeneTree; ENSGT00520000060257; -.
DR   InParanoid; H3BZ69; -.
DR   OMA; MATCEDS; -.
DR   OrthoDB; EOG7DZ8N6; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   185 AA;  21402 MW;  9C7298062C8166F6 CRC64;
     MAAGGHTLVG FFHADETVFY FNDLQDDSFH LWFVSPKWIK SKRNKFLILD DSEEFRAQDL
     SVDERECHPE RKFNVKYYKN SDSVGRTGVS LYVLKGDRKL TVCCNNRLEV HPGEMDVSEN
     VAGKAHQALF YLLEVASSCY LLESSLYPSM FLAFEPDEHD HTLSKLALRR KELEEVDESC
     YITML
//
ID   H3CVU5_TETNG            Unreviewed;       175 AA.
AC   H3CVU5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000012379};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000012379, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000012379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000012379}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000012379}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSTNIT00000012570; ENSTNIP00000012379; ENSTNIG00000009506.
DR   eggNOG; ENOG410JGPV; Eukaryota.
DR   eggNOG; ENOG410YT8P; LUCA.
DR   GeneTree; ENSGT00390000016316; -.
DR   InParanoid; H3CVU5; -.
DR   OMA; ASHYYLS; -.
DR   OrthoDB; EOG7M6D88; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   175 AA;  20249 MW;  AD17AC427D3A4FF9 CRC64;
     LVAQSSKVTL VSRGSESFKQ EKSSNVMIQH VASHYYLSLV SEKIISASPN LSQHPERITI
     YSYKTNEVEQ GQYRGMPVVL NFTDSDCFLR CCQEDQRVFL QAEGCDKRRL RQISKSDESA
     LSFVFYMKAD LSKQRTFESA LHPGWFIRVE ESDQVGMAHL EREEEEYSFL FVIQK
//
ID   H9G558_ANOCA            Unreviewed;       147 AA.
AC   H9G558;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   08-JUN-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000001388};
GN   Name=LOC103279675 {ECO:0000313|Ensembl:ENSACAP00000001388};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Iguanidae; Polychrotinae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000001388, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000001388}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000001388};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L.,
RA   Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A.,
RA   Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K.,
RA   Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A.,
RA   Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y.,
RA   Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D.,
RA   de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z.,
RA   Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A.,
RA   Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S.,
RA   Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with
RT   birds and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000001388}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000001388}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSACAT00000001421; ENSACAP00000001388; ENSACAG00000001497.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H9G558; -.
DR   OMA; NANIFPI; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   147 AA;  16224 MW;  BE47B8C2DD0D969E CRC64;
     FRIWDLSQKY FFLENKTLVA VPKGSNSPGK ELLGVVPNRG IKDTNANIFP IIMGPQDGKR
     VLSCAGSGGQ PQIKIEEEDI MNLYGKNEPL KNFTFLNHTG DGQQTCSFES AAFPGWFLST
     STEPNKPISL SQKGGAEITT FYFEKSK
//
ID   H9G561_ANOCA            Unreviewed;       155 AA.
AC   H9G561;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   08-JUN-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000001395};
GN   Name=LOC103279672 {ECO:0000313|Ensembl:ENSACAP00000001395};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Iguanidae; Polychrotinae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000001395, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000001395}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000001395};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L.,
RA   Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A.,
RA   Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K.,
RA   Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A.,
RA   Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y.,
RA   Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D.,
RA   de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z.,
RA   Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A.,
RA   Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S.,
RA   Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with
RT   birds and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000001395}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000001395}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSACAT00000001428; ENSACAP00000001395; ENSACAG00000001501.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H9G561; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  17566 MW;  120FA32D706E0727 CRC64;
     FCSVNAALYK IWDVSQKFLI LMNNILVATS RDSMTPEELL AVLPNHSLDP TLQPIFLGLN
     DKTRTLSCME SGDGEPLLNL VERNILDLYS SHEESKSFTF YSRSNNQQQT CCFESAAFPG
     WFMSTSTEIN KPVRLSREGG PDITNFFCER KDPLE
//
ID   H9G562_ANOCA            Unreviewed;       184 AA.
AC   H9G562;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   08-JUN-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000001396};
GN   Name=LOC100551550 {ECO:0000313|Ensembl:ENSACAP00000001396};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Iguanidae; Polychrotinae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000001396, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000001396}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L.,
RA   Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A.,
RA   Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K.,
RA   Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A.,
RA   Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y.,
RA   Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D.,
RA   de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z.,
RA   Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A.,
RA   Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S.,
RA   Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with
RT   birds and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000001396}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000001396}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_003224250.1; XM_003224202.2.
DR   Ensembl; ENSACAT00000001429; ENSACAP00000001396; ENSACAG00000001507.
DR   GeneID; 100551550; -.
DR   KEGG; acs:100551550; -.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; H9G562; -.
DR   KO; K05481; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   184 AA;  21216 MW;  35B71E8D304183E7 CRC64;
     MSWDQEVAAL FSDKSRESDP GDYELQTAKL RTPWLFRIWD ISQKFLFLMG NMLLAKFQNA
     NMPDHLISVL PNTALDPKKK PIFMGLSDKN HSFCCVKSGE GQPQLQIVER SILQLYQEKK
     ELKPFTFYSK ADGGPETCSF ESAEFPNWFI STSSEPNRPI GLSPKESAEN TLFFFERKDS
     YFMM
//
ID   H9GM92_ANOCA            Unreviewed;       170 AA.
AC   H9GM92;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000015126};
DE   Flags: Fragment;
GN   Name=IL18 {ECO:0000313|Ensembl:ENSACAP00000015126};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Iguanidae; Polychrotinae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000015126, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000015126}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L.,
RA   Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A.,
RA   Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K.,
RA   Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A.,
RA   Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y.,
RA   Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D.,
RA   de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z.,
RA   Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A.,
RA   Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S.,
RA   Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with
RT   birds and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000015126}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000015126}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 28377.ENSACAP00000015126; -.
DR   Ensembl; ENSACAT00000015432; ENSACAP00000015126; ENSACAG00000015396.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; H9GM92; -.
DR   OMA; AFKFEYS; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   Proteomes; UP000001646; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSACAP00000015126}.
SQ   SEQUENCE   170 AA;  19967 MW;  E63C26DB5032418F CRC64;
     LEDLECDSWK NSGKCERTQI LRNRDNYVLL AQPDDHEDYR AVFQFMTDQE MQNASGIKFN
     IHSYEDSRPR GLSVAFTIEW NRKTYYMCVA KRNSQMKVEF KEGDVPKRIP GQTSNVIFYK
     MSFSEGGSQF YRFETALERG HYLAFERDGN NTTRLIIKKA TDEVDQTTEI
//
ID   H9H271_MELGA            Unreviewed;       294 AA.
AC   H9H271;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   11-MAY-2016, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMGAP00000017537};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSMGAP00000017537};
OS   Meleagris gallopavo (Common turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000017537, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000017537, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000017537}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000017537}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9103.ENSMGAP00000017537; -.
DR   Ensembl; ENSMGAT00000020127; ENSMGAP00000017537; ENSMGAG00000003598.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; H9H271; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001645; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IDA:AgBase.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0032602; P:chemokine production; IMP:AgBase.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN       56    119       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   294 AA;  31951 MW;  1FF398C2FCEF2081 CRC64;
     MAFVPDLDVL ESSSLSEETF YGPSCLCLQK VGMGGLGGTV ARCHGSAGCS AAALSLQKPR
     LDSEHTAVGV QVTVRKGRGA RSFRQAAVLV VAMTKLLRRP TRRDFADSDL SALLEEVFEP
     VTFQRLESSY AGAPAFRYTR SQSFDIFDIN QKCFVLESPT QLVALHLQGP SSSQKVRLNI
     ALYRPRGPRG SAGAGQTPVA LGIKGYKLYM SCVLSGAEPT LQLEEADVTR DIDSAELTRF
     VFYRLDSPAE GTTRFESAAF PGWFICTSLQ PRQPVGITNR PDQVNIATYK LSGR
//
ID   I36RA_HUMAN             Reviewed;         155 AA.
AC   Q9UBH0; A8K2I4; Q56AT9; Q7RTZ6;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   06-JUL-2016, entry version 139.
DE   RecName: Full=Interleukin-36 receptor antagonist protein;
DE            Short=IL-36Ra {ECO:0000303|PubMed:21965679};
DE   AltName: Full=FIL1 delta;
DE   AltName: Full=IL-1-related protein 3;
DE            Short=IL-1RP3;
DE   AltName: Full=Interleukin-1 HY1;
DE            Short=IL-1HY1;
DE   AltName: Full=Interleukin-1 delta;
DE            Short=IL-1 delta;
DE   AltName: Full=Interleukin-1 family member 5;
DE            Short=IL-1F5;
DE   AltName: Full=Interleukin-1 receptor antagonist homolog 1;
DE            Short=IL-1ra homolog 1;
DE   AltName: Full=Interleukin-1-like protein 1;
DE            Short=IL-1L1;
GN   Name=IL36RN; Synonyms=FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3;
GN   ORFNames=UNQ1896/PRO4342;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=10625660; DOI=10.1074/jbc.275.2.1169;
RA   Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E.,
RA   Sims J.E.;
RT   "Four new members expand the IL-1 superfamily.";
RL   J. Biol. Chem. 275:1169-1175(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal skin;
RX   PubMed=10512743; DOI=10.1006/bbrc.1999.1440;
RA   Mulero J.J., Pace A.M., Nelken S.T., Loeb D.B., Correa T.R.,
RA   Drmanac R., Ford J.E.;
RT   "IL1HY1: a novel interleukin-1 receptor antagonist gene.";
RL   Biochem. Biophys. Res. Commun. 263:702-706(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=11093146;
RX   DOI=10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S;
RA   Barton J.L., Herbst R., Bosisio D., Higgins L., Nicklin M.J.H.;
RT   "A tissue specific IL-1 receptor antagonist homolog from the IL-1
RT   cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.";
RL   Eur. J. Immunol. 30:3299-3308(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=11466363; DOI=10.4049/jimmunol.167.3.1440;
RA   Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S.,
RA   Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F.,
RA   Kastelein R.A.;
RT   "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function
RT   as an antagonist and agonist of NF-kappa B activation through the
RT   orphan IL-1 receptor-related protein 2.";
RL   J. Immunol. 167:1440-1446(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10860666; DOI=10.1006/geno.2000.6184;
RA   Busfield S.J., Comrack C.A., Yu G., Chickering T.W., Smutko J.S.,
RA   Zhou H., Leiby K.R., Holmgren L.M., Gearing D.P., Pan Y.;
RT   "Identification and gene organization of three novel members of the
RT   IL-1 family on human chromosome 2.";
RL   Genomics 66:213-216(2000).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-47.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [11]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [12]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [13]
RP   FUNCTION, AND CLEAVAGE OF INITIATOR METHIONINE.
RX   PubMed=21965679; DOI=10.1074/jbc.M111.267922;
RA   Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M.,
RA   Gabel C.A., Sims J.E.;
RT   "Interleukin-36 (IL-36) ligands require processing for full agonist
RT   (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra)
RT   activity.";
RL   J. Biol. Chem. 286:42594-42602(2011).
RN   [14]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=23147407; DOI=10.1002/eji.201242711;
RA   Gresnigt M.S., Roesler B., Jacobs C.W., Becker K.L., Joosten L.A.,
RA   van der Meer J.W., Netea M.G., Dinarello C.A., van de Veerdonk F.L.;
RT   "The IL-36 receptor pathway regulates Aspergillus fumigatus-induced
RT   Th1 and Th17 responses.";
RL   Eur. J. Immunol. 43:416-426(2013).
RN   [15]
RP   VARIANTS PSORS14 TRP-48 AND LEU-113.
RX   PubMed=21839423; DOI=10.1016/j.ajhg.2011.07.022;
RA   Onoufriadis A., Simpson M.A., Pink A.E., Di Meglio P., Smith C.H.,
RA   Pullabhatla V., Knight J., Spain S.L., Nestle F.O., Burden A.D.,
RA   Capon F., Trembath R.C., Barker J.N.;
RT   "Mutations in IL36RN/IL1F5 are associated with the severe episodic
RT   inflammatory skin disease known as generalized pustular psoriasis.";
RL   Am. J. Hum. Genet. 89:432-437(2011).
RN   [16]
RP   VARIANT PSORS14 PRO-27, AND CHARACTERIZATION OF VARIANT PSORS14
RP   PRO-27.
RX   PubMed=21848462; DOI=10.1056/NEJMoa1013068;
RA   Marrakchi S., Guigue P., Renshaw B.R., Puel A., Pei X.Y., Fraitag S.,
RA   Zribi J., Bal E., Cluzeau C., Chrabieh M., Towne J.E., Douangpanya J.,
RA   Pons C., Mansour S., Serre V., Makni H., Mahfoudh N., Fakhfakh F.,
RA   Bodemer C., Feingold J., Hadj-Rabia S., Favre M., Genin E.,
RA   Sahbatou M., Munnich A., Casanova J.L., Sims J.E., Turki H.,
RA   Bachelez H., Smahi A.;
RT   "Interleukin-36-receptor antagonist deficiency and generalized
RT   pustular psoriasis.";
RL   N. Engl. J. Med. 365:620-628(2011).
RN   [17]
RP   VARIANT PSORS14 ARG-123, AND CHARACTERIZATION OF VARIANT PSORS14
RP   ARG-123.
RX   PubMed=22903787; DOI=10.1002/humu.22203;
RA   Farooq M., Nakai H., Fujimoto A., Fujikawa H., Matsuyama A.,
RA   Kariya N., Aizawa A., Fujiwara H., Ito M., Shimomura Y.;
RT   "Mutation analysis of the IL36RN gene in 14 Japanese patients with
RT   generalized pustular psoriasis.";
RL   Hum. Mutat. 34:176-183(2013).
CC   -!- FUNCTION: Inhibits the activity of interleukin-36 (IL36A,IL36B and
CC       IL36G) by binding to receptor IL1RL2 and preventing its
CC       association with the coreceptor IL1RAP for signaling. Part of the
CC       IL-36 signaling system that is thought to be present in epithelial
CC       barriers and to take part in local inflammatory response; similar
CC       to the IL-1 system with which it shares the coreceptor. Proposed
CC       to play a role in skin inflammation. May be involved in the innate
CC       immune response to fungal pathogens, such as Aspergillus
CC       fumigatus. May activate an anti-inflammatory signaling pathway by
CC       recruiting SIGIRR. {ECO:0000269|PubMed:11466363,
CC       ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.
CC   -!- INTERACTION:
CC       Q04864:REL; NbExp=3; IntAct=EBI-465156, EBI-307352;
CC       Q9BWW4:SSBP3; NbExp=3; IntAct=EBI-465156, EBI-2902395;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in skin keratinocytes
CC       but not in fibroblasts, endothelial cells or melanocytes. Detected
CC       also in the spleen, brain leukocyte and macrophage cell types.
CC       Increased in lesional psoriasis skin.
CC       {ECO:0000269|PubMed:11466363}.
CC   -!- INDUCTION: By phorbol ester (PMA) and bacterial
CC       lipopolysaccharides (LPS) treatment in macrophage cell line. By
CC       Aspergillus fumigatus conidia in peripheral blood mnonocytes.
CC       {ECO:0000269|PubMed:23147407}.
CC   -!- DISEASE: Psoriasis 14, pustular (PSORS14) [MIM:614204]: A life-
CC       threatening disease defined by repeated flares of sudden onset
CC       consisting of diffuse erythematous skin eruption characterized by
CC       rapid coverage with pustules, high-grade fever, asthenia, marked
CC       leukocytosis, and elevated serum levels of C-reactive protein.
CC       {ECO:0000269|PubMed:21839423, ECO:0000269|PubMed:21848462,
CC       ECO:0000269|PubMed:22903787}. Note=The disease is caused by
CC       mutations affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="https://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1f5/";
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DR   EMBL; AF201830; AAF25210.1; -; mRNA.
DR   EMBL; AF186094; AAF02757.1; -; mRNA.
DR   EMBL; AJ242737; CAB59822.1; -; mRNA.
DR   EMBL; AJ242738; CAB59823.1; -; mRNA.
DR   EMBL; AJ271338; CAB67704.1; -; Genomic_DNA.
DR   EMBL; AF216693; AAF76981.1; -; Genomic_DNA.
DR   EMBL; AF230377; AAF91274.1; -; mRNA.
DR   EMBL; BN000002; CAD29877.1; -; Genomic_DNA.
DR   EMBL; AY359117; AAQ89475.1; -; mRNA.
DR   EMBL; AK290249; BAF82938.1; -; mRNA.
DR   EMBL; AY972853; AAX59031.1; -; Genomic_DNA.
DR   EMBL; AC016724; AAY14990.1; -; Genomic_DNA.
DR   EMBL; CH471217; EAW73617.1; -; Genomic_DNA.
DR   EMBL; BC024747; AAH24747.1; -; mRNA.
DR   CCDS; CCDS2111.1; -.
DR   PIR; JC7104; JC7104.
DR   RefSeq; NP_036407.1; NM_012275.2.
DR   RefSeq; NP_775262.1; NM_173170.1.
DR   UniGene; Hs.516301; -.
DR   PDB; 4P0J; X-ray; 2.30 A; A/B=2-135, A/B=147-155.
DR   PDB; 4P0K; X-ray; 1.70 A; A=2-49, A=55-135, A=147-155.
DR   PDB; 4P0L; X-ray; 1.55 A; A=2-49, A=55-135, A=147-155.
DR   PDBsum; 4P0J; -.
DR   PDBsum; 4P0K; -.
DR   PDBsum; 4P0L; -.
DR   ProteinModelPortal; Q9UBH0; -.
DR   SMR; Q9UBH0; 4-154.
DR   BioGrid; 117728; 15.
DR   IntAct; Q9UBH0; 7.
DR   MINT; MINT-1194342; -.
DR   STRING; 9606.ENSP00000259212; -.
DR   iPTMnet; Q9UBH0; -.
DR   BioMuta; IL36RN; -.
DR   DMDM; 25008600; -.
DR   PaxDb; Q9UBH0; -.
DR   PeptideAtlas; Q9UBH0; -.
DR   PRIDE; Q9UBH0; -.
DR   DNASU; 26525; -.
DR   Ensembl; ENST00000346807; ENSP00000259212; ENSG00000136695.
DR   Ensembl; ENST00000393200; ENSP00000376896; ENSG00000136695.
DR   GeneID; 26525; -.
DR   KEGG; hsa:26525; -.
DR   UCSC; uc002tis.4; human.
DR   CTD; 26525; -.
DR   GeneCards; IL36RN; -.
DR   HGNC; HGNC:15561; IL36RN.
DR   HPA; HPA034542; -.
DR   MalaCards; IL36RN; -.
DR   MIM; 605507; gene.
DR   MIM; 614204; phenotype.
DR   neXtProt; NX_Q9UBH0; -.
DR   Orphanet; 163931; Acrodermatitis continua suppurativa of Hallopeau.
DR   Orphanet; 404546; DITRA.
DR   Orphanet; 247353; Generalized pustular psoriasis.
DR   Orphanet; 163927; Pustulosis palmaris et plantaris.
DR   PharmGKB; PA38388; -.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; Q9UBH0; -.
DR   KO; K05483; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   PhylomeDB; Q9UBH0; -.
DR   TreeFam; TF300203; -.
DR   GeneWiki; IL1F5; -.
DR   GenomeRNAi; 26525; -.
DR   PRO; PR:Q9UBH0; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; Q9UBH0; -.
DR   CleanEx; HS_IL1F5; -.
DR   ExpressionAtlas; Q9UBH0; baseline and differential.
DR   Genevisible; Q9UBH0; HS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005152; F:interleukin-1 receptor antagonist activity; TAS:ProtInc.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IMP:UniProtKB.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IMP:UniProtKB.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IMP:UniProtKB.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytokine; Disease mutation;
KW   Disulfide bond; Immunity; Innate immunity; Polymorphism;
KW   Reference proteome; Secreted.
FT   INIT_MET      1      1       Removed. {ECO:0000269|PubMed:21965679}.
FT   CHAIN         2    155       Interleukin-36 receptor antagonist
FT                                protein.
FT                                /FTId=PRO_0000153642.
FT   DISULFID      8    154       {ECO:0000250}.
FT   VARIANT      27     27       L -> P (in PSORS14; expression of the
FT                                protein is severely impaired compared to
FT                                wild-type; the mutant protein is
FT                                substantially less able to inhibit IL1RL2
FT                                signaling than wild-type;
FT                                dbSNP:rs387906914).
FT                                {ECO:0000269|PubMed:21848462}.
FT                                /FTId=VAR_066646.
FT   VARIANT      47     47       N -> S (in dbSNP:rs28938777).
FT                                {ECO:0000269|Ref.9}.
FT                                /FTId=VAR_023239.
FT   VARIANT      48     48       R -> W (in PSORS14; dbSNP:rs151325121).
FT                                {ECO:0000269|PubMed:21839423}.
FT                                /FTId=VAR_066647.
FT   VARIANT     113    113       S -> L (in PSORS14; dbSNP:rs144478519).
FT                                {ECO:0000269|PubMed:21839423}.
FT                                /FTId=VAR_066648.
FT   VARIANT     123    123       T -> R (in PSORS14; shows impaired
FT                                expression of the mutant protein which
FT                                fails to antagonize the IL-36 signaling
FT                                pathway; dbSNP:rs397514629).
FT                                {ECO:0000269|PubMed:22903787}.
FT                                /FTId=VAR_068972.
FT   STRAND        9     13       {ECO:0000244|PDB:4P0L}.
FT   STRAND       18     22       {ECO:0000244|PDB:4P0L}.
FT   STRAND       25     29       {ECO:0000244|PDB:4P0L}.
FT   STRAND       42     46       {ECO:0000244|PDB:4P0L}.
FT   HELIX        52     54       {ECO:0000244|PDB:4P0J}.
FT   STRAND       55     61       {ECO:0000244|PDB:4P0L}.
FT   TURN         62     65       {ECO:0000244|PDB:4P0L}.
FT   STRAND       66     69       {ECO:0000244|PDB:4P0L}.
FT   STRAND       72     75       {ECO:0000244|PDB:4P0L}.
FT   STRAND       79     82       {ECO:0000244|PDB:4P0L}.
FT   HELIX        85     89       {ECO:0000244|PDB:4P0L}.
FT   HELIX        96     98       {ECO:0000244|PDB:4P0L}.
FT   STRAND       99    104       {ECO:0000244|PDB:4P0L}.
FT   STRAND      109    116       {ECO:0000244|PDB:4P0L}.
FT   STRAND      120    123       {ECO:0000244|PDB:4P0L}.
FT   STRAND      132    135       {ECO:0000244|PDB:4P0L}.
FT   STRAND      149    153       {ECO:0000244|PDB:4P0L}.
SQ   SEQUENCE   155 AA;  16962 MW;  B96DB5EFA2612E25 CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
     VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF
     LCTVPEADQP VRLTQLPENG GWNAPITDFY FQQCD
//
ID   I36RA_MOUSE             Reviewed;         156 AA.
AC   Q9QYY1; Q9JIG2;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2002, sequence version 2.
DT   06-JUL-2016, entry version 122.
DE   RecName: Full=Interleukin-36 receptor antagonist protein;
DE            Short=IL-36Ra {ECO:0000303|PubMed:21965679};
DE   AltName: Full=Interleukin-1 HY1;
DE            Short=IL-1HY1;
DE   AltName: Full=Interleukin-1 delta;
DE            Short=IL-1 delta;
DE   AltName: Full=Interleukin-1 family member 5;
DE            Short=IL-1F5;
DE   AltName: Full=Interleukin-1 homolog 3;
DE            Short=IL-1H3;
DE   AltName: Full=Interleukin-1-like protein 1;
DE            Short=IL-1L1;
GN   Name=IL36RN; Synonyms=Fil1d, Il1f5, Il1h3, Il1hy1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11093146;
RX   DOI=10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S;
RA   Barton J.L., Herbst R., Bosisio D., Higgins L., Nicklin M.J.H.;
RT   "A tissue specific IL-1 receptor antagonist homolog from the IL-1
RT   cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.";
RL   Eur. J. Immunol. 30:3299-3308(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10744718; DOI=10.1074/jbc.275.14.10308;
RA   Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N.,
RA   Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L.,
RA   Young P.R.;
RT   "Identification and initial characterization of four novel members of
RT   the interleukin-1 family.";
RL   J. Biol. Chem. 275:10308-10314(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11466363; DOI=10.4049/jimmunol.167.3.1440;
RA   Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S.,
RA   Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F.,
RA   Kastelein R.A.;
RT   "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function
RT   as an antagonist and agonist of NF-kappa B activation through the
RT   orphan IL-1 receptor-related protein 2.";
RL   J. Immunol. 167:1440-1446(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Stomach, and Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [5]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=17908936; DOI=10.1084/jem.20070157;
RA   Blumberg H., Dinh H., Trueblood E.S., Pretorius J., Kugler D.,
RA   Weng N., Kanaly S.T., Towne J.E., Willis C.R., Kuechle M.K.,
RA   Sims J.E., Peschon J.J.;
RT   "Opposing activities of two novel members of the IL-1 ligand family
RT   regulate skin inflammation.";
RL   J. Exp. Med. 204:2603-2614(2007).
RN   [6]
RP   FUNCTION.
RX   PubMed=18284608; DOI=10.1111/j.1471-4159.2008.05304.x;
RA   Costelloe C., Watson M., Murphy A., McQuillan K., Loscher C.,
RA   Armstrong M.E., Garlanda C., Mantovani A., O'Neill L.A., Mills K.H.,
RA   Lynch M.A.;
RT   "IL-1F5 mediates anti-inflammatory activity in the brain through
RT   induction of IL-4 following interaction with SIGIRR/TIR8.";
RL   J. Neurochem. 105:1960-1969(2008).
RN   [7]
RP   FUNCTION.
RX   PubMed=21860022; DOI=10.1182/blood-2011-05-356873;
RA   Vigne S., Palmer G., Lamacchia C., Martin P., Talabot-Ayer D.,
RA   Rodriguez E., Ronchi F., Sallusto F., Dinh H., Sims J.E., Gabay C.;
RT   "IL-36R ligands are potent regulators of dendritic and T cells.";
RL   Blood 118:5813-5823(2011).
RN   [8]
RP   FUNCTION, AND CLEAVAGE OF INITIATOR METHIONINE.
RX   PubMed=21965679; DOI=10.1074/jbc.M111.267922;
RA   Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M.,
RA   Gabel C.A., Sims J.E.;
RT   "Interleukin-36 (IL-36) ligands require processing for full agonist
RT   (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra)
RT   activity.";
RL   J. Biol. Chem. 286:42594-42602(2011).
RN   [9]
RP   X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 3-156, AND DISULFIDE BOND.
RX   PubMed=12974628; DOI=10.1021/bi0341197;
RA   Dunn E.F., Gay N.J., Bristow A.F., Gearing D.P., O'Neill L.A.J.,
RA   Pei X.Y.;
RT   "High-resolution structure of murine interleukin 1 homologue IL-1F5
RT   reveals unique loop conformations for receptor binding specificity.";
RL   Biochemistry 42:10938-10944(2003).
CC   -!- FUNCTION: Inhibits the activity of interleukin-36 (IL36A,IL36B and
CC       IL36G) by binding to receptor IL1RL2/IL-36R and preventing its
CC       association with the coreceptor IL1RAP for signaling. Part of the
CC       IL-36 signaling system that is thought to be present in epithelial
CC       barriers and to take part in local inflammatory response; similar
CC       to the IL-1 system with which it shares the coreceptor. Proposed
CC       to play a role in skin inflammation. May be involved in the innate
CC       immune response to fungal pathogens. May activate an anti-
CC       inflammatory signaling pathway by recruiting SIGIRR.
CC       {ECO:0000269|PubMed:17908936, ECO:0000269|PubMed:18284608,
CC       ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly abundant in embryonic tissue and
CC       tissues containing epithelial cells.
CC   -!- PTM: Removal of N-terminal methionine is necessary for full
CC       antagonistic activity. {ECO:0000269|PubMed:21965679}.
CC   -!- DISRUPTION PHENOTYPE: In combination with transgenic IL36A
CC       exacerbates skin abnormalities (acanthosis, hyperkeratosis,
CC       presence of a mixed inflammatory cell infiltrate and increased
CC       cytokine and chemokine expression). {ECO:0000269|PubMed:17908936}.
CC   -!- MISCELLANEOUS: Bioactive (processed) recombinant IL36RN inhibits
CC       effects of IL-36 when used in 100- 1000-fold molar excess.
CC       {ECO:0000269|PubMed:21860022}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB59831.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AJ250429; CAB59831.1; ALT_INIT; mRNA.
DR   EMBL; AF200495; AAF69251.1; -; mRNA.
DR   EMBL; AF230378; AAF91275.1; -; mRNA.
DR   EMBL; AK008977; BAB26002.1; -; mRNA.
DR   EMBL; AK009741; BAB26471.1; -; mRNA.
DR   CCDS; CCDS50519.1; -.
DR   RefSeq; NP_001139559.1; NM_001146087.1.
DR   RefSeq; NP_001139560.1; NM_001146088.1.
DR   RefSeq; NP_062324.2; NM_019451.2.
DR   UniGene; Mm.29261; -.
DR   PDB; 1MD6; X-ray; 1.60 A; A=3-156.
DR   PDBsum; 1MD6; -.
DR   ProteinModelPortal; Q9QYY1; -.
DR   SMR; Q9QYY1; 3-156.
DR   STRING; 10090.ENSMUSP00000028360; -.
DR   MaxQB; Q9QYY1; -.
DR   PaxDb; Q9QYY1; -.
DR   PRIDE; Q9QYY1; -.
DR   Ensembl; ENSMUST00000028360; ENSMUSP00000028360; ENSMUSG00000026983.
DR   Ensembl; ENSMUST00000114490; ENSMUSP00000110134; ENSMUSG00000026983.
DR   Ensembl; ENSMUST00000168941; ENSMUSP00000126028; ENSMUSG00000026983.
DR   GeneID; 54450; -.
DR   KEGG; mmu:54450; -.
DR   UCSC; uc008ios.2; mouse.
DR   CTD; 54450; -.
DR   MGI; MGI:1859325; Il1f5.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; Q9QYY1; -.
DR   KO; K05483; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   PhylomeDB; Q9QYY1; -.
DR   TreeFam; TF300203; -.
DR   EvolutionaryTrace; Q9QYY1; -.
DR   PRO; PR:Q9QYY1; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; Q9QYY1; -.
DR   CleanEx; MM_IL1F5; -.
DR   ExpressionAtlas; Q9QYY1; baseline and differential.
DR   Genevisible; Q9QYY1; MM.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; ISO:MGI.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; ISO:MGI.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; ISO:MGI.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; ISO:MGI.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IGI:MGI.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytokine; Disulfide bond; Immunity;
KW   Innate immunity; Reference proteome; Secreted.
FT   INIT_MET      1      1       Removed. {ECO:0000269|PubMed:21965679}.
FT   CHAIN         2    156       Interleukin-36 receptor antagonist
FT                                protein.
FT                                /FTId=PRO_0000153643.
FT   DISULFID      9    155       {ECO:0000269|PubMed:12974628}.
FT   CONFLICT      2      2       Missing (in Ref. 3; AAF69251).
FT                                {ECO:0000305}.
FT   STRAND        8     14       {ECO:0000244|PDB:1MD6}.
FT   STRAND       19     23       {ECO:0000244|PDB:1MD6}.
FT   STRAND       26     29       {ECO:0000244|PDB:1MD6}.
FT   HELIX        32     35       {ECO:0000244|PDB:1MD6}.
FT   STRAND       43     47       {ECO:0000244|PDB:1MD6}.
FT   HELIX        53     55       {ECO:0000244|PDB:1MD6}.
FT   STRAND       57     62       {ECO:0000244|PDB:1MD6}.
FT   TURN         63     66       {ECO:0000244|PDB:1MD6}.
FT   STRAND       67     70       {ECO:0000244|PDB:1MD6}.
FT   STRAND       73     76       {ECO:0000244|PDB:1MD6}.
FT   STRAND       80     83       {ECO:0000244|PDB:1MD6}.
FT   HELIX        86     91       {ECO:0000244|PDB:1MD6}.
FT   STRAND       92     94       {ECO:0000244|PDB:1MD6}.
FT   HELIX        97     99       {ECO:0000244|PDB:1MD6}.
FT   STRAND      100    105       {ECO:0000244|PDB:1MD6}.
FT   STRAND      110    117       {ECO:0000244|PDB:1MD6}.
FT   STRAND      121    124       {ECO:0000244|PDB:1MD6}.
FT   STRAND      126    131       {ECO:0000244|PDB:1MD6}.
FT   STRAND      133    135       {ECO:0000244|PDB:1MD6}.
FT   STRAND      150    154       {ECO:0000244|PDB:1MD6}.
SQ   SEQUENCE   156 AA;  17136 MW;  A4D1EE2F93CF77A7 CRC64;
     MMVLSGALCF RMKDSALKVL YLHNNQLLAG GLHAEKVIKG EEISVVPNRA LDASLSPVIL
     GVQGGSQCLS CGTEKGPILK LEPVNIMELY LGAKESKSFT FYRRDMGLTS SFESAAYPGW
     FLCTSPEADQ PVRLTQIPED PAWDAPITDF YFQQCD
//
ID   I3J5Z9_ORENI            Unreviewed;       350 AA.
AC   I3J5Z9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 21.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000004289};
GN   Name=LOC100699119 {ECO:0000313|Ensembl:ENSONIP00000004289};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004289, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000004289}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000004289}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AERX01013970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003445852.1; XM_003445804.3.
DR   Ensembl; ENSONIT00000004290; ENSONIP00000004289; ENSONIG00000003405.
DR   GeneID; 100699119; -.
DR   eggNOG; ENOG410JGPV; Eukaryota.
DR   eggNOG; ENOG410YT8P; LUCA.
DR   GeneTree; ENSGT00390000016316; -.
DR   InParanoid; I3J5Z9; -.
DR   OMA; ITIYYYK; -.
DR   OrthoDB; EOG7M6D88; -.
DR   Proteomes; UP000005207; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR001478; PDZ.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   350 AA;  39122 MW;  EBB1380FE80C8594 CRC64;
     MDTKESLVKG GVLIAHKINE GKHQYVVENV VKYKNDNGGK LYVRKGDKLL QINGMDLNDL
     TPEELANVIA EGSPMLTVCK PASEEDHTEE TSLTEDTLHP VSKESTVLSF SWEMTREDDP
     EGIEVEPQEE EKETGNIEED LCQAKTEENE IFVVEMTKTS ISLVRGRGCD ATGCTLNDII
     MVAESSTVTL VPRGGGTFRQ EKLSNVLIEN LATHQYLRGI CSERIVYASP NPERITIYYY
     KSSGLIRGSS GLPVVLNLTD SNCFLMCCKQ ADRVLLKVET CEKQRLKQIS KSDESTLSFV
     FYMKGDSARR RSFESALYRG WFINVCNTDT VGVATPDGRV DQSFLFIIQK
//
ID   I3JNP5_ORENI            Unreviewed;       114 AA.
AC   I3JNP5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=IL-1-beta {ECO:0000313|EMBL:AIA57771.1};
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:AHM10343.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000010489};
GN   Name=IL-1beta {ECO:0000313|EMBL:AHM10343.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010489, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000010489}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:AHM10343.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:AHM10343.1};
RA   Ma L.;
RT   "Molecular cloning, expression and functional analysis of interleukin-
RT   1beta (IL-1beta) in Oreochromis niloticus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
RN   [4] {ECO:0000313|EMBL:AIA57771.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Gill {ECO:0000313|EMBL:AIA57771.1};
RA   Ma L.;
RT   "Molecular structure, tissue distribution and functional
RT   characterization of interleukin-1-beta in Oreochromis niloticus.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
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DR   EMBL; AERX01077211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF747686; AHM10343.1; -; mRNA.
DR   EMBL; KJ574402; AIA57771.1; -; mRNA.
DR   STRING; 8128.ENSONIP00000010489; -.
DR   Ensembl; ENSONIT00000010498; ENSONIP00000010489; ENSONIG00000008343.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   OMA; ISVESDM; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   Proteomes; UP000005207; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:AHM10343.1}.
SQ   SEQUENCE   114 AA;  13005 MW;  2DA96936A7E52B8F CRC64;
     MSTYAHPTPI AETRPVALGI KGTNLYLSCH KDDDKPTLHL EEVTDKNSLS RISAESDMVR
     FLFYKRDTGV SISTLMSVRY PNWYISTAQD DDQVVEVCQE TAPRYRSFNI QLQS
//
ID   I3JZ37_ORENI            Unreviewed;       255 AA.
AC   I3JZ37;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000014132};
GN   Name=LOC100693282 {ECO:0000313|Ensembl:ENSONIP00000014132};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014132, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000014132}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000014132}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AERX01030049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005457944.1; XM_005457887.1.
DR   STRING; 8128.ENSONIP00000014132; -.
DR   Ensembl; ENSONIT00000014142; ENSONIP00000014132; ENSONIG00000011230.
DR   GeneID; 100693282; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; I3JZ37; -.
DR   OMA; ESVKFRG; -.
DR   OrthoDB; EOG72G19J; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005207; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   255 AA;  29114 MW;  05C4BEE1D38158CB CRC64;
     MCDIDLSQAL DCSPEEAIKS TCFDMKEVES EIFRLNEGLE LMVSHNRRTM QSVALLVLGV
     NRMKKPLTQS DRKLSDDDVM NIIDSVVKET VWPPTKGTKR RDFLRANSEK ALTLCDNSQK
     DLVLSGELQL QAITLQGGNC HRKVNFKMSR YIPSVPPGDS PGLIVVLSIN NNLYMSCRME
     ADKVVLFLEQ YHDDILTDRD MERFLFYRKT TGISLTTFES VKFRGWYIST SQQENQPVEL
     CKVDAASRLT NFRVN
//
ID   I3JZ38_ORENI            Unreviewed;       241 AA.
AC   I3JZ38;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 19.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000014133};
GN   Name=LOC100693282 {ECO:0000313|Ensembl:ENSONIP00000014133};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014133, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000014133}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000014133}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AERX01030049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSONIT00000014143; ENSONIP00000014133; ENSONIG00000011230.
DR   GeneTree; ENSGT00510000048687; -.
DR   Proteomes; UP000005207; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   241 AA;  27487 MW;  1EAE2A03030D751F CRC64;
     MEGGPKSSMS QMKVSRLNEG LELMVSHNRR TMQSVALLVL GVNRMKKPLT QSDRKLSDDD
     VMNIIDSVVK ETVWPPTKGT KRRDFLRANS EKALTLCDNS QKDLVLSGEL QLQAITLQGG
     NCHRKVNFKM SRYIPSVPPG DSPGLIVVLS INNNLYMSCR MEADKVVLFL EQYHDDILTD
     RDMERFLFYR KTTGISLTTF ESVKFRGWYI STSQQENQPV ELCKVDAASR LTNFRVYSRH
     S
//
ID   I3KDY4_ORENI            Unreviewed;       178 AA.
AC   I3KDY4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 18.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000019329};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000019329, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000019329}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000019329}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AERX01038042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01038043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01038044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01038045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01038046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSONIT00000019346; ENSONIP00000019329; ENSONIG00000015364.
DR   InParanoid; I3KDY4; -.
DR   OrthoDB; EOG7DZ8N6; -.
DR   Proteomes; UP000005207; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   178 AA;  20583 MW;  628BF3D1BDBE7753 CRC64;
     MESNSCINVE FLDTAEDSFY FGVVQQDLKE DDFTQPKDHH WSIESTNGFG YLILNQEDTF
     VLQTCCEKKL CIRTYRSSFV NEKLPVMIYT QKNDQTMVAC CKEHKIQAVP MTLPTDITGT
     NHDALFYQTR LRGSNRFKFV FSVDPDKVLG VVNENNLYKL TLLPKVDDVD TRVEFVVK
//
ID   I3LZ39_ICTTR            Unreviewed;       148 AA.
AC   I3LZ39;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000001542};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSSTOP00000001542};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001542, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000001542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000001542}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000001542}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01106916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSTOT00000001723; ENSSTOP00000001542; ENSSTOG00000001727.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; I3LZ39; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   148 AA;  16853 MW;  6674FE7F68C5BB72 CRC64;
     PQTWEVSDRD QQVWILQGET LVMVPRSSNV TPATVTILPC KYPESLEQGR GVPIYLGTQD
     PDLCLFCEEV DRWPVLWLKE QNILDLYNQV EPVRPFLFYH SRDGNTSTFE SVAFPGWLIA
     SSQVGQPIFL TSDLGTTNNT NFYLNLKA
//
ID   I3LZ42_ICTTR            Unreviewed;       160 AA.
AC   I3LZ42;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000001545};
GN   Name=IL36A {ECO:0000313|Ensembl:ENSSTOP00000001545};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001545, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000001545}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000001545}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000001545}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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DR   EMBL; AGTP01106917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01106918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000001545; -.
DR   Ensembl; ENSSTOT00000001728; ENSSTOP00000001545; ENSSTOG00000001732.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; I3LZ42; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   160 AA;  18529 MW;  B6F1753D38F88A87 CRC64;
     LTFSSALASE VPSRRYVQDL NHRAWVLQDQ TLMIVPRKER MVPITVTLMP CRHLETLEKD
     RGKPMYLGLL EPNCCLFCKK DGEQPVLQLE ERSIIDLHAF REPVKPFLFY HSETGRTSTF
     ESVAFPGWFI AVCSKGDCPL FMTQELGKTY ITDFELIRQN
//
ID   I3M045_ICTTR            Unreviewed;       268 AA.
AC   I3M045;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000002041};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSSTOP00000002041};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000002041, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000002041}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000002041}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000002041}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01106904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005340300.1; XM_005340243.1.
DR   STRING; 43179.ENSSTOP00000002041; -.
DR   Ensembl; ENSSTOT00000002284; ENSSTOP00000002041; ENSSTOG00000002285.
DR   GeneID; 101959879; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; I3M045; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30518 MW;  39DBC2458E9DC60E CRC64;
     MAKVPDLFED LKDCYSEDED YNSTMDHLSL HQKSFYTTSY HSLGETCVDK LMSRSTSETS
     KTSKLTFKES LVLVSANGKT LKKRRLSFHQ PISDDDLEAI AYDLEEEPIK PRSASRLLQS
     NVSYTYKRII QKEFSLNDPL HQSIIQDPTS QYLKATSLTD QDQEVKFDMG AYISTTEDSK
     FPVTLRISKT HLFVSAQEED EPVLLKEMPE TPKIITGSDT NLIFFWESHS DMNYFTSAAH
     PELLIATKVD SAVHMARGLP SMTEFQIS
//
ID   I3M051_ICTTR            Unreviewed;       272 AA.
AC   I3M051;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000002047};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSSTOP00000002047};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000002047, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000002047}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000002047}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000002047}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01106906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01106907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000002047; -.
DR   Ensembl; ENSSTOT00000002290; ENSSTOP00000002047; ENSSTOG00000002292.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; I3M051; -.
DR   OMA; YPKKRME; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1     86       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   272 AA;  30992 MW;  B8A0485EBF6A3B24 CRC64;
     MAAVPELASE MMAYHSSDEN DLFFEVDGPK HMKRGWPWEL THACPFFLPG MELSVGRKPE
     KKDLCRKIQN SLSEPRSTEK VMIVMVPKIL IPRWLCLDDL CLLIPEPIFC DPWDDDGYEY
     DAAVPVLNCR LRDVQQKSLV LSDPCELKAL HLNGPNLRQQ VVFSMSFVLG EGNDSKTPVA
     LGIKGKNLYL TCVMKGDKPT LQLESVDPKS YPKKRMEPRF VFNKIEVKDK VEFESAQFPN
     WYISTSQAEH LPVFLGNNSG QDITDFTMEF VS
//
ID   I3MC07_ICTTR            Unreviewed;       212 AA.
AC   I3MC07;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 21.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000007749};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSSTOP00000007749};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000007749, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000007749}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000007749}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000007749}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01106912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01106913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000007749; -.
DR   Ensembl; ENSSTOT00000008644; ENSSTOP00000007749; ENSSTOG00000008646.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; I3MC07; -.
DR   OMA; RKHTEFS; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   212 AA;  23706 MW;  A61C134288BF2E55 CRC64;
     MSFLEDNTGE NMDFEDWEEE EAQCCSEDPA GSPMETGQSQ ASVSSVHTSP RVKAKEPQKF
     SIFDRDHKVL VLDSGTLKAI PHKSYILPET FFVLASHLAK PSEEKGSPIL LAVSKGEFCL
     CCDKNKGKRK PSLQLKKKKL MSLAAQKETS RRAYVFYKSK VGSRYTLESA AHPGWFICTS
     RNSGDPVTVT DKTGRRKHTE FSFENPSKTE MS
//
ID   I3MMX8_ICTTR            Unreviewed;       121 AA.
AC   I3MMX8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000012938};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSSTOP00000012938};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012938, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000012938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000012938}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000012938}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01106923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSTOT00000014443; ENSSTOP00000012938; ENSSTOG00000014442.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; I3MMX8; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   121 AA;  13392 MW;  CBA61FC1D15B4E9C CRC64;
     GEEISVVPNR SLDASLSPVI LGVQGGSQCL SCGTEKEPTL KLEPVNIMEL YCSAKESKSF
     TFYWRDMGLT SSFESAAYPG WFLCTAPEAD QPVRLTQIPE DAAWDTPWDA PITDFYFQPC
     D
//
ID   I3MMX9_ICTTR            Unreviewed;       152 AA.
AC   I3MMX9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000012940};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSSTOP00000012940};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012940, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000012940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000012940}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000012940}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01106925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005340301.1; XM_005340244.1.
DR   STRING; 43179.ENSSTOP00000012940; -.
DR   Ensembl; ENSSTOT00000014445; ENSSTOP00000012940; ENSSTOG00000014447.
DR   GeneID; 101960155; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; I3MMX9; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16860 MW;  A42D13146E10556D CRC64;
     MCSLPMAKYY IIKDADQKAL YTRDGQLLVG DPDTADCSAE KICVLPNRDL DRAKVPILLG
     LQGGSRCLAC VQTEEGPSLQ LEDVNIEDLY KGGERATRFT FFQSSLGSAF RLEAAACPGW
     FLCGPEEPQQ PVRLAKESEP SARTEFYFEQ SR
//
ID   I3MMY3_ICTTR            Unreviewed;       177 AA.
AC   I3MMY3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000012946};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSSTOP00000012946};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012946, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000012946}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000012946}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000012946}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01106929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005340302.1; XM_005340245.2.
DR   STRING; 43179.ENSSTOP00000012946; -.
DR   Ensembl; ENSSTOT00000014451; ENSSTOP00000012946; ENSSTOG00000014450.
DR   GeneID; 101960446; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; I3MMY3; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    177       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003677000.
SQ   SEQUENCE   177 AA;  20049 MW;  D8E2DFCE1D37F088 CRC64;
     MEMCRGPCSH LISLLLFLLH SEAACRPLGR RPCRMQAFRI WDINQKTFYL RNNQLVAGYL
     QGPNIKLEEK IDMVPIDPHA MFLGIRGGKL CLSCVKSGDD MRLQLEAVNI TNLSGTKEQD
     KRFSFIRSDN GPTTSFESAA CPGWFICTAL EADQPVSLTN RPEDTLVVTK FYFQEDQ
//
ID   I3MN57_ICTTR            Unreviewed;       167 AA.
AC   I3MN57;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000013041};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSSTOP00000013041};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013041, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000013041}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000013041}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000013041}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01106920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSTOT00000014556; ENSSTOP00000013041; ENSSTOG00000014564.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; I3MN57; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   167 AA;  18529 MW;  9BE20E7D0871B935 CRC64;
     FSFSLFSEHS ACLENPQDMP VFYTIRDSQQ MVWVLSGDVL IAAPSSNNVQ PVTLTLIACR
     DTALHDEEKG NLVFLGIKGK DLSFCCAEAE GQPTLQLKEV SIMELYRENK ARTPFLFFHS
     LEGSTSAFQS ASHPGWFIAT SSTAKQPVTL TQERGLANTN FYLGREN
//
ID   I3MSL6_ICTTR            Unreviewed;       193 AA.
AC   I3MSL6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000015111};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSSTOP00000015111};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000015111, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000015111}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000015111}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000015111}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01076244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005334277.1; XM_005334220.2.
DR   STRING; 43179.ENSSTOP00000015111; -.
DR   Ensembl; ENSSTOT00000024258; ENSSTOP00000015111; ENSSTOG00000022148.
DR   GeneID; 101961568; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; I3MSL6; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22670 MW;  6C9E1E96D526BEA9 CRC64;
     MAAAPTENNY INFVEMTFID DTLYFKAEDD DNLESDYFGK IELRLSILRN LNDQVLFVDR
     REQPVFEDMT DCDILGNEPR TTFEIYIYKD SQPRGLAVAI SVKCEKYYTL SCENKNISFK
     EIHPPDNINE TKSDIIFFQR AVPGHDDKRQ FESSLYEGYF LACKKEKDLY KLTLKKQDDS
     RDKSIMFTVI NKN
//
ID   I3MVA2_ICTTR            Unreviewed;       171 AA.
AC   I3MVA2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000016047};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000016047, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000016047}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000016047}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000016047}.
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DR   EMBL; AGTP01106913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000016047; -.
DR   Ensembl; ENSSTOT00000027726; ENSSTOP00000016047; ENSSTOG00000027018.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; I3MVA2; -.
DR   OMA; LPFTFLK; -.
DR   OrthoDB; EOG7G4QHM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   171 AA;  18846 MW;  C71BF3336F8C5B11 CRC64;
     RIKSVTCSKF LIRDPNQQVL VLEGGVLKAV PDRHTRTGEI FYIATSKETS SISSGSTTEA
     NHIFLAVCKG KLCLCCDKVK EPKCPLLELK NKNISELNSL DEEYSLPFTF IQEMVGSYFT
     LESAANPGCF ICTSKTPMQP VGMTKEPGKE NNTQFKFQIA NADLNSTHSA D
//
ID   IL18_BOVIN              Reviewed;         193 AA.
AC   Q9TU73; A9QWR6; Q3SZF6;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   08-JUN-2016, entry version 99.
DE   RecName: Full=Interleukin-18;
DE            Short=IL-18;
DE   AltName: Full=Interferon gamma-inducing factor;
DE            Short=IFN-gamma-inducing factor;
DE   AltName: Full=Interleukin-1 gamma;
DE            Short=IL-1 gamma;
DE   Flags: Precursor;
GN   Name=IL18; Synonyms=IGIF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10547157; DOI=10.1089/107999099313118;
RA   Shoda L.K., Zarlenga D.S., Hirano A., Brown W.C.;
RT   "Cloning of a cDNA encoding bovine interleukin-18 and analysis of IL-
RT   18 expression in macrophages and its IFN-gamma-inducing activity.";
RL   J. Interferon Cytokine Res. 19:1169-1177(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Belted Galloway; TISSUE=Peripheral blood;
RG   U.S. Veterinary Immune Reagent Network;
RA   Hudgens T., Tompkins D., Baldwin C.L.;
RT   "U.S. veterinary immune reagent network: expressed bovine gene
RT   sequences.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Augments natural killer cell activity in spleen cells
CC       and stimulates interferon gamma production in T-helper type I
CC       cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
CC       yield the active form. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; AF124789; AAF08686.1; -; mRNA.
DR   EMBL; EU276078; ABX72076.1; -; mRNA.
DR   EMBL; BC102879; AAI02880.1; -; mRNA.
DR   RefSeq; NP_776516.1; NM_174091.2.
DR   UniGene; Bt.234; -.
DR   ProteinModelPortal; Q9TU73; -.
DR   SMR; Q9TU73; 37-193.
DR   STRING; 9913.ENSBTAP00000055793; -.
DR   PaxDb; Q9TU73; -.
DR   PRIDE; Q9TU73; -.
DR   Ensembl; ENSBTAT00000065052; ENSBTAP00000055793; ENSBTAG00000000277.
DR   GeneID; 281249; -.
DR   KEGG; bta:281249; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   HOGENOM; HOG000048723; -.
DR   HOVERGEN; HBG000388; -.
DR   InParanoid; Q9TU73; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Reactome; R-BTA-448706; Interleukin-1 processing.
DR   Reactome; R-BTA-449147; Signaling by Interleukins.
DR   Proteomes; UP000009136; Chromosome 15.
DR   ExpressionAtlas; Q9TU73; baseline and differential.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Reference proteome; Secreted.
FT   PROPEP        1     36       {ECO:0000250}.
FT                                /FTId=PRO_0000015337.
FT   CHAIN        37    193       Interleukin-18.
FT                                /FTId=PRO_0000015338.
SQ   SEQUENCE   193 AA;  22347 MW;  65720F199DEA49C4 CRC64;
     MAAEQVEDYC ISFVEMKFIN NTLYFVAEND EDLESDHFGK LEPKLSIIRN LNDQVLFINQ
     GNQPVFEDMP DSDCSDNAPQ TIFIIYMYKD SLTRGLAVTI SVQCKKMSTL SCENKIVSFK
     EMNPPDNIDN EESDIIFFQR SVPGHDDKIQ FESSLYKGYF LACKKENDLF KLILKKQDDN
     RDKSVMFTVQ NQN
//
ID   IL18_CANLF              Reviewed;         193 AA.
AC   Q9XSR0;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   08-JUN-2016, entry version 83.
DE   RecName: Full=Interleukin-18;
DE            Short=IL-18;
DE   AltName: Full=Interferon gamma-inducing factor;
DE            Short=IFN-gamma-inducing factor;
DE   AltName: Full=Interleukin-1 gamma;
DE            Short=IL-1 gamma;
DE   Flags: Precursor;
GN   Name=IL18; Synonyms=IGIF;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10380699; DOI=10.1007/s002510050532;
RA   Argyle D.J., McGillivery C., Nicolson L., Onions D.E.;
RT   "Cloning, sequencing, and characterization of dog interleukin-18.";
RL   Immunogenetics 49:541-543(1999).
CC   -!- FUNCTION: Augments natural killer cell activity in spleen cells
CC       and stimulates interferon gamma production in T-helper type I
CC       cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
CC       yield the active form. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; Y11133; CAA72015.1; -; mRNA.
DR   RefSeq; NP_001003169.1; NM_001003169.1.
DR   UniGene; Cfa.40; -.
DR   ProteinModelPortal; Q9XSR0; -.
DR   SMR; Q9XSR0; 37-192.
DR   STRING; 9615.ENSCAFP00000038185; -.
DR   PaxDb; Q9XSR0; -.
DR   GeneID; 403796; -.
DR   KEGG; cfa:403796; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   HOGENOM; HOG000048723; -.
DR   HOVERGEN; HBG000388; -.
DR   InParanoid; Q9XSR0; -.
DR   KO; K05482; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005576; C:extracellular region; TAS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; TAS:UniProtKB.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEP:UniProtKB.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Reference proteome; Secreted.
FT   PROPEP        1     36       {ECO:0000250}.
FT                                /FTId=PRO_0000015339.
FT   CHAIN        37    193       Interleukin-18.
FT                                /FTId=PRO_0000015340.
SQ   SEQUENCE   193 AA;  22037 MW;  0D973E586F461F25 CRC64;
     MAANLIEDNC INLVKMKFVN NTLYFKAESD EGLESDYFGK LEPKLSIIRN LNDQVLFVNE
     GNQPVFEDMP DSDCTDNAPH TIFIIYMYKD SLTRGLAVTI SVKYKTMSTL SCKNKTISFQ
     KMSPPDSIND EGNDIIFFQR SVPGHDDKIQ FESSLYKGHF LACKKENDLF KLILKDKDEN
     GDKSIMFTVQ NKS
//
ID   IL18_CHICK              Reviewed;         196 AA.
AC   Q8QFQ8;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   17-FEB-2016, entry version 69.
DE   RecName: Full=Interleukin-18;
DE            Short=IL-18;
DE   Flags: Precursor;
GN   Name=IL18;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Rothwell L., Buerstedde J.-M., Kaiser P.;
RT   "Cloning and characterisation of chicken interleukin-18.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Augments natural killer cell activity in spleen cells
CC       and stimulates interferon gamma production in T-helper type I
CC       cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
CC       yield the active form. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; AJ276025; CAC81652.1; -; mRNA.
DR   UniGene; Gga.17593; -.
DR   ProteinModelPortal; Q8QFQ8; -.
DR   STRING; 9031.ENSGALP00000012772; -.
DR   PaxDb; Q8QFQ8; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   HOVERGEN; HBG102119; -.
DR   InParanoid; Q8QFQ8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0035710; P:CD4-positive, alpha-beta T cell activation; IDA:AgBase.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:1902715; P:positive regulation of interferon-gamma secretion; IDA:AgBase.
DR   GO; GO:0050671; P:positive regulation of lymphocyte proliferation; IDA:AgBase.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Reference proteome; Secreted.
FT   PROPEP        1     29       {ECO:0000255}.
FT                                /FTId=PRO_0000015351.
FT   CHAIN        30    196       Interleukin-18.
FT                                /FTId=PRO_0000015352.
SQ   SEQUENCE   196 AA;  22787 MW;  4947DECECCB92414 CRC64;
     MSCEEIAVCA VRLRENLCLY FEELECDAFC KDKTIKRFFR NVNSQLLVVR PDLNVAAFED
     VTDQEVKSGS GMYFDIHCYK TTAPSARMPV AFSVQVEDKS YYMCCEKEHG KMVVRFREGE
     VPKDIPGESN IIFFKKTFTS CSSKAFKFEY SLEQGMFLAF EEEDSLRKLI LKKLPREDEV
     DETTKFVTSH NERHNL
//
ID   IL18_FELCA              Reviewed;         192 AA.
AC   Q95M33; Q865B8;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   17-FEB-2016, entry version 53.
DE   RecName: Full=Interleukin-18;
DE            Short=IL-18;
DE   AltName: Full=Interferon gamma-inducing factor;
DE            Short=IFN-gamma-inducing factor;
DE   AltName: Full=Interleukin-1 gamma;
DE            Short=IL-1 gamma;
DE   Flags: Precursor;
GN   Name=IL18; Synonyms=IGIF;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Alveolar macrophage;
RA   Hanlon L., McGillivray C.P., Argyle D.J.A., Nicolson L., Onions D.E.;
RT   "Nucleotide sequence of feline IGIF cDNA.";
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kuwahara C., Kawakami K., Kishi M., Mochizuki M.;
RT   "Feline interleukin-18.";
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lymphocyte;
RA   Qiao J., Xia X., Yang S.;
RT   "Cloning and sequence analysis of feline IL-18 gene.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Augments natural killer cell activity in spleen cells
CC       and stimulates interferon gamma production in T-helper type I
CC       cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
CC       yield the active form. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; Y13923; CAC42918.1; -; mRNA.
DR   EMBL; AB056857; BAC65243.1; -; mRNA.
DR   EMBL; DQ100372; AAY96319.1; -; mRNA.
DR   RefSeq; NP_001009213.2; NM_001009213.2.
DR   ProteinModelPortal; Q95M33; -.
DR   SMR; Q95M33; 36-192.
DR   STRING; 9685.ENSFCAP00000017529; -.
DR   GeneID; 493688; -.
DR   KEGG; fca:493688; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   HOVERGEN; HBG000388; -.
DR   InParanoid; Q95M33; -.
DR   KO; K05482; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Reference proteome; Secreted.
FT   PROPEP        1     35       {ECO:0000250}.
FT                                /FTId=PRO_0000252354.
FT   CHAIN        36    192       Interleukin-18.
FT                                /FTId=PRO_0000252355.
FT   CONFLICT      4      4       I -> E (in Ref. 2; BAC65243).
FT                                {ECO:0000305}.
FT   CONFLICT      7      7       D -> E (in Ref. 2; BAC65243).
FT                                {ECO:0000305}.
FT   CONFLICT    192    192       N -> S (in Ref. 2; BAC65243).
FT                                {ECO:0000305}.
SQ   SEQUENCE   192 AA;  22068 MW;  5878C3DAC7A43358 CRC64;
     MAAIPVDDCI NFVGMKFIDN TLYFVADSDE NLETDYFGKL EHKLSILRNL NDQVLFINQG
     DQPVFEDMPD SDCTDNAPRT EFIIYMYKDS LTRGLAVTIS VNYKTMSTLS CENKIISFKE
     MSPPESINDE GNDIIFFQRS VPGHDDKIQF ESSLYKGYFL ACEKEKDLFK LILKKKDENG
     DKSIMFTVQN KN
//
ID   IL18_HORSE              Reviewed;         193 AA.
AC   Q9XSQ7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   06-JUL-2016, entry version 87.
DE   RecName: Full=Interleukin-18;
DE            Short=IL-18;
DE   AltName: Full=Interferon gamma-inducing factor;
DE            Short=IFN-gamma-inducing factor;
DE   AltName: Full=Interleukin-1 gamma;
DE            Short=IL-1 gamma;
DE   Flags: Precursor;
GN   Name=IL18; Synonyms=IGIF;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10541814; DOI=10.1007/s002510050693;
RA   Nicolson L., Penha-Goncalves M.N., Keanie J.L., Logan N.A.,
RA   Argyle D.J., Onions D.E.;
RT   "Cloning and sequencing of horse interleukin-12 and interleukin-18
RT   cDNAs.";
RL   Immunogenetics 50:94-97(1999).
CC   -!- FUNCTION: Augments natural killer cell activity in spleen cells
CC       and stimulates interferon gamma production in T-helper type I
CC       cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
CC       yield the active form. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; Y11131; CAA72013.1; -; mRNA.
DR   RefSeq; NP_001075981.1; NM_001082512.1.
DR   RefSeq; XP_005611483.1; XM_005611426.2.
DR   RefSeq; XP_005611484.1; XM_005611427.2.
DR   UniGene; Eca.3121; -.
DR   ProteinModelPortal; Q9XSQ7; -.
DR   SMR; Q9XSQ7; 37-193.
DR   STRING; 9796.ENSECAP00000013028; -.
DR   PaxDb; Q9XSQ7; -.
DR   PeptideAtlas; Q9XSQ7; -.
DR   Ensembl; ENSECAT00000016149; ENSECAP00000013028; ENSECAG00000015261.
DR   GeneID; 100034216; -.
DR   KEGG; ecb:100034216; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   HOGENOM; HOG000048723; -.
DR   HOVERGEN; HBG000388; -.
DR   InParanoid; Q9XSQ7; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000002281; Chromosome 7.
DR   ExpressionAtlas; Q9XSQ7; baseline.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Reference proteome; Secreted.
FT   PROPEP        1     36       {ECO:0000250}.
FT                                /FTId=PRO_0000015341.
FT   CHAIN        37    193       Interleukin-18.
FT                                /FTId=PRO_0000015342.
SQ   SEQUENCE   193 AA;  22058 MW;  4D81535E9004ECAF CRC64;
     MAAGPVEDNC ISLVEMKFID NTLYFVAEND ENLESDYFGR LEPKLSIIRN LNDQVLFINQ
     GNQPVFEDMP DSDCTDNAPQ TVFIIYMYKD SLTRGLAVTI SVKCEKTSTL SCKNKIISFK
     EMSPPENIND EGNDIIFFQR SVPGHDDKIQ FESSLYKGYF LACEKENDLF KLILKEKDEN
     GDKSVMFTVQ NQN
//
ID   IL18_HUMAN              Reviewed;         193 AA.
AC   Q14116; O75599; Q6FGY3; Q6WWJ7;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   06-JUL-2016, entry version 156.
DE   RecName: Full=Interleukin-18;
DE            Short=IL-18;
DE   AltName: Full=Iboctadekin;
DE   AltName: Full=Interferon gamma-inducing factor;
DE            Short=IFN-gamma-inducing factor;
DE   AltName: Full=Interleukin-1 gamma;
DE            Short=IL-1 gamma;
DE   Flags: Precursor;
GN   Name=IL18; Synonyms=IGIF, IL1F4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Liver;
RX   PubMed=8666798;
RA   Ushio S., Namba M., Okura T., Hattori K., Nukada Y., Akita K.,
RA   Tanabe F., Konishi K., Micallef M., Fujii M., Torigoe K., Tanimoto T.,
RA   Fukuda S., Ikeda M., Okamura H., Kurimoto M.;
RT   "Cloning of the cDNA for human IFN-gamma-inducing factor, expression
RT   in Escherichia coli, and studies on the biologic activities of the
RT   protein.";
RL   J. Immunol. 156:4274-4279(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEOLYTIC PROCESSING, AND
RP   ALTERNATIVE SPLICING.
RX   PubMed=15326478; DOI=10.1038/sj.onc.1208036;
RA   Gaggero A., De Ambrosis A., Mezzanzanica D., Piazza T., Rubartelli A.,
RA   Figini M., Canevari S., Ferrini S.;
RT   "A novel isoform of pro-interleukin-18 expressed in ovarian tumors is
RT   resistant to caspase-1 and -4 processing.";
RL   Oncogene 23:7552-7560(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Yong D., Guixin D., Lihua H., Haitao W.;
RT   "Cloning and sequencing of the cDNA for precursor hIL-18.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Liu J., Peng X., Yuan J., Qiang B.;
RT   "Cloning of human interleukin 18 cDNA.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA   Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA   FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA   Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA   Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA   Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Urinary bladder;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 2-193 (ISOFORM 1).
RC   TISSUE=Peripheral blood;
RA   Conti B., Kim S.J., Tinti C., Chun H.S., Joh T.H.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: Augments natural killer cell activity in spleen cells
CC       and stimulates interferon gamma production in T-helper type I
CC       cells.
CC   -!- INTERACTION:
CC       Q13478:IL18R1; NbExp=2; IntAct=EBI-3910835, EBI-9817499;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q14116-1; Sequence=Displayed;
CC       Name=2; Synonyms=Delta3pro-IL-18;
CC         IsoId=Q14116-2; Sequence=VSP_044934;
CC         Note=Expressed in ovarian carcinoma but undetectable in normal
CC         ovarian epithelial cells. Resistant to proteolytic activation by
CC         caspase-1 and -4.;
CC   -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
CC       yield the active form. {ECO:0000269|PubMed:15326478}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="https://en.wikipedia.org/wiki/Interleukin_1";
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DR   EMBL; D49950; BAA08706.1; -; mRNA.
DR   EMBL; AY266351; AAP92112.1; -; mRNA.
DR   EMBL; AF077611; AAC27787.1; -; mRNA.
DR   EMBL; AY044641; AAK95950.1; -; mRNA.
DR   EMBL; CR541973; CAG46771.1; -; mRNA.
DR   EMBL; CR542001; CAG46798.1; -; mRNA.
DR   EMBL; AP002007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471065; EAW67184.1; -; Genomic_DNA.
DR   EMBL; BC007007; AAH07007.1; -; mRNA.
DR   EMBL; BC007461; AAH07461.1; -; mRNA.
DR   EMBL; U90434; AAB50010.1; -; mRNA.
DR   CCDS; CCDS44731.1; -. [Q14116-1]
DR   CCDS; CCDS58180.1; -. [Q14116-2]
DR   RefSeq; NP_001230140.1; NM_001243211.1. [Q14116-2]
DR   RefSeq; NP_001553.1; NM_001562.3. [Q14116-1]
DR   RefSeq; XP_011541107.1; XM_011542805.1. [Q14116-2]
DR   RefSeq; XP_011541108.1; XM_011542806.1. [Q14116-1]
DR   UniGene; Hs.83077; -.
DR   PDB; 1J0S; NMR; -; A=37-193.
DR   PDB; 2VXT; X-ray; 1.49 A; I=37-193.
DR   PDB; 3F62; X-ray; 2.00 A; B=37-193.
DR   PDB; 3WO2; X-ray; 2.33 A; A/B/C/D=37-193.
DR   PDB; 3WO3; X-ray; 3.10 A; A/C/E/G/I/K=37-193.
DR   PDB; 3WO4; X-ray; 3.10 A; A=37-193.
DR   PDB; 4EEE; X-ray; 2.71 A; B/D=37-193.
DR   PDB; 4EKX; X-ray; 1.75 A; B/D=37-193.
DR   PDB; 4HJJ; X-ray; 2.10 A; A=37-192.
DR   PDB; 4R6U; X-ray; 2.80 A; B/D=37-193.
DR   PDB; 4XFS; X-ray; 1.91 A; A/B=37-193.
DR   PDB; 4XFT; X-ray; 2.00 A; A/B=37-193.
DR   PDB; 4XFU; X-ray; 2.85 A; A/B=37-193.
DR   PDBsum; 1J0S; -.
DR   PDBsum; 2VXT; -.
DR   PDBsum; 3F62; -.
DR   PDBsum; 3WO2; -.
DR   PDBsum; 3WO3; -.
DR   PDBsum; 3WO4; -.
DR   PDBsum; 4EEE; -.
DR   PDBsum; 4EKX; -.
DR   PDBsum; 4HJJ; -.
DR   PDBsum; 4R6U; -.
DR   PDBsum; 4XFS; -.
DR   PDBsum; 4XFT; -.
DR   PDBsum; 4XFU; -.
DR   ProteinModelPortal; Q14116; -.
DR   SMR; Q14116; 37-193.
DR   BioGrid; 109819; 11.
DR   DIP; DIP-3785N; -.
DR   IntAct; Q14116; 3.
DR   STRING; 9606.ENSP00000280357; -.
DR   iPTMnet; Q14116; -.
DR   PhosphoSite; Q14116; -.
DR   BioMuta; IL18; -.
DR   DMDM; 3219817; -.
DR   OGP; Q14116; -.
DR   EPD; Q14116; -.
DR   MaxQB; Q14116; -.
DR   PaxDb; Q14116; -.
DR   PeptideAtlas; Q14116; -.
DR   PRIDE; Q14116; -.
DR   DNASU; 3606; -.
DR   Ensembl; ENST00000280357; ENSP00000280357; ENSG00000150782. [Q14116-1]
DR   Ensembl; ENST00000524595; ENSP00000434561; ENSG00000150782. [Q14116-2]
DR   Ensembl; ENST00000528832; ENSP00000434161; ENSG00000150782. [Q14116-1]
DR   GeneID; 3606; -.
DR   KEGG; hsa:3606; -.
DR   UCSC; uc001pnb.2; human. [Q14116-1]
DR   CTD; 3606; -.
DR   GeneCards; IL18; -.
DR   HGNC; HGNC:5986; IL18.
DR   HPA; CAB007772; -.
DR   HPA; CAB027385; -.
DR   HPA; HPA003980; -.
DR   MIM; 600953; gene.
DR   neXtProt; NX_Q14116; -.
DR   PharmGKB; PA29802; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   HOGENOM; HOG000048723; -.
DR   HOVERGEN; HBG000388; -.
DR   InParanoid; Q14116; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   PhylomeDB; Q14116; -.
DR   TreeFam; TF336297; -.
DR   Reactome; R-HSA-448706; Interleukin-1 processing.
DR   Reactome; R-HSA-449147; Signaling by Interleukins.
DR   SIGNOR; Q14116; -.
DR   EvolutionaryTrace; Q14116; -.
DR   GeneWiki; Interleukin_18; -.
DR   GenomeRNAi; 3606; -.
DR   PMAP-CutDB; Q14116; -.
DR   PRO; PR:Q14116; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; Q14116; -.
DR   CleanEx; HS_IL18; -.
DR   ExpressionAtlas; Q14116; baseline and differential.
DR   Genevisible; Q14116; HS.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; TAS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; TAS:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; IDA:UniProtKB.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IDA:UniProtKB.
DR   GO; GO:0042033; P:chemokine biosynthetic process; TAS:UniProtKB.
DR   GO; GO:0042253; P:granulocyte macrophage colony-stimulating factor biosynthetic process; TAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; TAS:ProtInc.
DR   GO; GO:0006954; P:inflammatory response; IDA:UniProtKB.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; TAS:UniProtKB.
DR   GO; GO:0042231; P:interleukin-13 biosynthetic process; TAS:UniProtKB.
DR   GO; GO:0042094; P:interleukin-2 biosynthetic process; TAS:UniProtKB.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IDA:UniProtKB.
DR   GO; GO:0000165; P:MAPK cascade; IMP:UniProtKB.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IDA:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IDA:BHF-UCL.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IC:BHF-UCL.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:BHF-UCL.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IDA:BHF-UCL.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IDA:BHF-UCL.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IDA:BHF-UCL.
DR   GO; GO:0034105; P:positive regulation of tissue remodeling; IC:BHF-UCL.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IDA:CACAO.
DR   GO; GO:0030155; P:regulation of cell adhesion; IDA:UniProtKB.
DR   GO; GO:0030431; P:sleep; ISS:UniProtKB.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IDA:UniProtKB.
DR   GO; GO:0042092; P:type 2 immune response; TAS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Complete proteome; Cytokine;
KW   Reference proteome; Secreted.
FT   PROPEP        1     36       {ECO:0000250}.
FT                                /FTId=PRO_0000015343.
FT   CHAIN        37    193       Interleukin-18.
FT                                /FTId=PRO_0000015344.
FT   VAR_SEQ      27     30       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15326478}.
FT                                /FTId=VSP_044934.
FT   CONFLICT     66     66       F -> L (in Ref. 3; AAC27787).
FT                                {ECO:0000305}.
FT   CONFLICT     86     86       S -> R (in Ref. 3; AAC27787).
FT                                {ECO:0000305}.
FT   CONFLICT    191    191       N -> S (in Ref. 3; AAC27787).
FT                                {ECO:0000305}.
FT   STRAND       42     49       {ECO:0000244|PDB:2VXT}.
FT   STRAND       55     58       {ECO:0000244|PDB:2VXT}.
FT   STRAND       64     67       {ECO:0000244|PDB:2VXT}.
FT   HELIX        71     76       {ECO:0000244|PDB:2VXT}.
FT   TURN         77     81       {ECO:0000244|PDB:2VXT}.
FT   STRAND       83     91       {ECO:0000244|PDB:2VXT}.
FT   TURN         92     94       {ECO:0000244|PDB:2VXT}.
FT   STRAND       95    111       {ECO:0000244|PDB:2VXT}.
FT   HELIX       113    115       {ECO:0000244|PDB:2VXT}.
FT   STRAND      118    121       {ECO:0000244|PDB:2VXT}.
FT   STRAND      126    131       {ECO:0000244|PDB:2VXT}.
FT   STRAND      137    142       {ECO:0000244|PDB:2VXT}.
FT   STRAND      145    156       {ECO:0000244|PDB:2VXT}.
FT   STRAND      159    166       {ECO:0000244|PDB:2VXT}.
FT   STRAND      169    176       {ECO:0000244|PDB:2VXT}.
FT   TURN        178    180       {ECO:0000244|PDB:4HJJ}.
FT   HELIX       183    185       {ECO:0000244|PDB:2VXT}.
FT   STRAND      187    191       {ECO:0000244|PDB:2VXT}.
SQ   SEQUENCE   193 AA;  22326 MW;  323C62C203788D55 CRC64;
     MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN LNDQVLFIDQ
     GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK
     EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL
     GDRSIMFTVQ NED
//
ID   IL18_MOUSE              Reviewed;         192 AA.
AC   P70380;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   06-JUL-2016, entry version 129.
DE   RecName: Full=Interleukin-18;
DE            Short=IL-18;
DE   AltName: Full=Interferon gamma-inducing factor;
DE            Short=IFN-gamma-inducing factor;
DE   AltName: Full=Interleukin-1 gamma;
DE            Short=IL-1 gamma;
DE   Flags: Precursor;
GN   Name=Il18; Synonyms=Igif;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   PubMed=7477296; DOI=10.1038/378088a0;
RA   Okamura H., Tsutui H., Komatsu T., Yutsudo M., Hakura A., Tanimoto T.,
RA   Torigoe K., Okura T., Nukada Y., Hattori K., Akita K., Namba M.,
RA   Tanabe F., Konishi K., Fukuda S., Kurimoto M.;
RT   "Cloning of a new cytokine that induces IFN-gamma production by T
RT   cells.";
RL   Nature 378:88-91(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-191.
RC   STRAIN=NOD; TISSUE=Pancreas;
RX   PubMed=9022080; DOI=10.1172/JCI119181;
RA   Rothe H., Jenkins N.A., Copeland N.G., Kolb H.;
RT   "Active stage of autoimmune diabetes is associated with the expression
RT   of a novel cytokine, IGIF, which is located near Idd2.";
RL   J. Clin. Invest. 99:469-474(1997).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Augments natural killer cell activity in spleen cells
CC       and stimulates interferon gamma production in T-helper type I
CC       cells.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
CC       yield the active form. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; D49949; BAA08705.1; -; mRNA.
DR   EMBL; BC024384; AAH24384.1; -; mRNA.
DR   EMBL; U66244; AAB49753.1; -; mRNA.
DR   CCDS; CCDS40622.1; -.
DR   PIR; S60226; S60226.
DR   RefSeq; NP_032386.1; NM_008360.1.
DR   RefSeq; XP_006510089.1; XM_006510026.1.
DR   RefSeq; XP_006510090.1; XM_006510027.2.
DR   RefSeq; XP_006510091.1; XM_006510028.2.
DR   UniGene; Mm.1410; -.
DR   ProteinModelPortal; P70380; -.
DR   SMR; P70380; 37-188.
DR   DIP; DIP-950N; -.
DR   STRING; 10090.ENSMUSP00000137193; -.
DR   PhosphoSite; P70380; -.
DR   PaxDb; P70380; -.
DR   PRIDE; P70380; -.
DR   Ensembl; ENSMUST00000180021; ENSMUSP00000137193; ENSMUSG00000039217.
DR   GeneID; 16173; -.
DR   KEGG; mmu:16173; -.
DR   UCSC; uc009pju.1; mouse.
DR   CTD; 3606; -.
DR   MGI; MGI:107936; Il18.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   HOGENOM; HOG000048723; -.
DR   HOVERGEN; HBG000388; -.
DR   InParanoid; P70380; -.
DR   KO; K05482; -.
DR   PhylomeDB; P70380; -.
DR   Reactome; R-MMU-448706; Interleukin-1 processing.
DR   Reactome; R-MMU-449147; Signaling by Interleukins.
DR   PRO; PR:P70380; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   Bgee; P70380; -.
DR   CleanEx; MM_IL18; -.
DR   ExpressionAtlas; P70380; baseline and differential.
DR   Genevisible; P70380; MM.
DR   GO; GO:0070062; C:extracellular exosome; ISO:MGI.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR   GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; ISO:MGI.
DR   GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; TAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; TAS:MGI.
DR   GO; GO:0006954; P:inflammatory response; IGI:MGI.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IMP:UniProtKB.
DR   GO; GO:0042231; P:interleukin-13 biosynthetic process; TAS:UniProtKB.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISO:MGI.
DR   GO; GO:0000165; P:MAPK cascade; ISO:MGI.
DR   GO; GO:0030101; P:natural killer cell activation; IDA:MGI.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IMP:MGI.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; ISO:MGI.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:MGI.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; ISO:MGI.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; ISO:MGI.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IDA:MGI.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; ISO:MGI.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISO:MGI.
DR   GO; GO:0030155; P:regulation of cell adhesion; ISS:UniProtKB.
DR   GO; GO:0030431; P:sleep; ISS:UniProtKB.
DR   GO; GO:0042088; P:T-helper 1 type immune response; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytokine; Direct protein sequencing;
KW   Reference proteome; Secreted.
FT   PROPEP        1     35
FT                                /FTId=PRO_0000015345.
FT   CHAIN        36    192       Interleukin-18.
FT                                /FTId=PRO_0000015346.
FT   CONFLICT    183    185       MFT -> IS (in Ref. 3; AAB49753).
FT                                {ECO:0000305}.
SQ   SEQUENCE   192 AA;  22135 MW;  8FED938473874D63 CRC64;
     MAAMSEDSCV NFKEMMFIDN TLYFIPEENG DLESDNFGRL HCTTAVIRNI NDQVLFVDKR
     QPVFEDMTDI DQSASEPQTR LIIYMYKDSE VRGLAVTLSV KDSKMSTLSC KNKIISFEEM
     DPPENIDDIQ SDLIFFQKRV PGHNKMEFES SLYEGHFLAC QKEDDAFKLI LKKKDENGDK
     SVMFTLTNLH QS
//
ID   IL18_PIG                Reviewed;         192 AA.
AC   O19073; Q1HDI4;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   08-JUN-2016, entry version 93.
DE   RecName: Full=Interleukin-18;
DE            Short=IL-18;
DE   AltName: Full=Interferon gamma-inducing factor;
DE            Short=IFN-gamma-inducing factor;
DE   AltName: Full=Interleukin-1 gamma;
DE            Short=IL-1 gamma;
DE   Flags: Precursor;
GN   Name=IL18; Synonyms=IGIF;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Foss D.L., Murtaugh M.P.;
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Penha-Goncalves M.N., Logan N.A., Nicolson L., Onions D.E.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Muneta Y., Mori Y.;
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Intestine;
RX   PubMed=10803849; DOI=10.1007/s002510050630;
RA   Fournout S., Dozois C.M., Yerle M., Pinton P., Fairbrother J.M.,
RA   Oswald E., Oswald I.P.;
RT   "Cloning, chromosomal location, and tissue expression of the gene for
RT   pig interleukin-18.";
RL   Immunogenetics 51:358-365(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zheng L., Cui B., Chen H., Fang Z., Chen R.;
RT   "Cloning and sequencing of the pig interleukin-18.";
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Augments natural killer cell activity in spleen cells
CC       and stimulates interferon gamma production in T-helper type I
CC       cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
CC       yield the active form. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; U68701; AAC18415.1; -; mRNA.
DR   EMBL; Y11132; CAA72014.1; -; mRNA.
DR   EMBL; AB010003; BAA24135.1; -; mRNA.
DR   EMBL; AF191088; AAF71200.1; -; mRNA.
DR   EMBL; DQ499825; ABF55514.1; -; mRNA.
DR   RefSeq; NP_999162.1; NM_213997.1.
DR   RefSeq; XP_005667383.1; XM_005667326.2.
DR   UniGene; Ssc.20; -.
DR   ProteinModelPortal; O19073; -.
DR   SMR; O19073; 36-192.
DR   STRING; 9823.ENSSSCP00000015962; -.
DR   PaxDb; O19073; -.
DR   Ensembl; ENSSSCT00000016403; ENSSSCP00000015962; ENSSSCG00000015037.
DR   GeneID; 397057; -.
DR   KEGG; ssc:397057; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   HOGENOM; HOG000048723; -.
DR   HOVERGEN; HBG000388; -.
DR   InParanoid; O19073; -.
DR   KO; K05482; -.
DR   OMA; PVFEDMP; -.
DR   TreeFam; TF336297; -.
DR   Reactome; R-SSC-448706; Interleukin-1 processing.
DR   Reactome; R-SSC-449147; Signaling by Interleukins.
DR   Proteomes; UP000008227; Chromosome 9.
DR   ExpressionAtlas; O19073; differential.
DR   Genevisible; O19073; SS.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005125; F:cytokine activity; IMP:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IDA:UniProtKB.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Reference proteome; Secreted.
FT   PROPEP        1     35       {ECO:0000250}.
FT                                /FTId=PRO_0000015347.
FT   CHAIN        36    192       Interleukin-18.
FT                                /FTId=PRO_0000015348.
FT   CONFLICT    184    184       I -> V (in Ref. 5; ABF55514).
FT                                {ECO:0000305}.
SQ   SEQUENCE   192 AA;  22026 MW;  881EA654E221A17A CRC64;
     MAAEPEDNCI SFVEMKFINN TLYFVAENDE DLESDYFGKL EPKLSIIRNL NDQVLFINQG
     HQAVFEDMPD SDCSDNAPQT VFIIYMYKDS LTRGLAVTIS VQCKKMSTLS CKNKTLSFKE
     MSPPDNIDDE GNDIIFFQRS VPGHDDKIQF ESSLYKGYFL ACKKENDLFK LILKEKDECG
     DKSIMFTVQN KN
//
ID   IL18_RAT                Reviewed;         194 AA.
AC   P97636; O88749; P97637; Q541E6;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   06-JUL-2016, entry version 122.
DE   RecName: Full=Interleukin-18;
DE            Short=IL-18;
DE   AltName: Full=Interferon gamma-inducing factor;
DE            Short=IFN-gamma-inducing factor;
DE   AltName: Full=Interleukin-1 gamma;
DE            Short=IL-1 gamma;
DE   Flags: Precursor;
GN   Name=Il18; Synonyms=Igif;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
RC   STRAIN=Sprague-Dawley; TISSUE=Adrenal gland;
RX   PubMed=8999896; DOI=10.1074/jbc.272.4.2035;
RA   Conti B., Jahng J.W., Tinti C., Son J.H., Joh T.H.;
RT   "Induction of interferon-gamma inducing factor in the adrenal
RT   cortex.";
RL   J. Biol. Chem. 272:2035-2037(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=9702748; DOI=10.1038/sj.mp.4000389;
RA   Culhane A.C., Hall M.D., Rothwell N.J., Luheshi G.N.;
RT   "Cloning of rat brain interleukin-18 cDNA.";
RL   Mol. Psychiatry 3:362-366(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
RC   STRAIN=New England Deaconess Hospital; TISSUE=Adrenal gland;
RA   Kim S.-J., Kim C.-S., Song K.-Y., Kim J.-S., Jung K.-S.;
RT   "Cloning of the cDNA for interleukin-18 in PC12 and expression in
RT   Escherichia coli.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
RC   STRAIN=Fischer 344;
RX   PubMed=12787406; DOI=10.1046/j.1523-1755.2003.00077.x;
RA   Garcia G.E., Xia Y., Ku G., Johnson R.J., Wilson C.B., Feng L.;
RT   "IL-18 translational inhibition restricts IFN-gamma expression in
RT   crescentic glomerulonephritis.";
RL   Kidney Int. 64:160-169(2003).
CC   -!- FUNCTION: Augments natural killer cell activity in spleen cells
CC       and stimulates interferon gamma production in T-helper type I
CC       cells.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Beta;
CC         IsoId=P97636-1; Sequence=Displayed;
CC       Name=Alpha;
CC         IsoId=P97636-2; Sequence=VSP_002659;
CC   -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
CC       yield the active form. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; U77776; AAC53009.1; -; mRNA.
DR   EMBL; U77777; AAC53010.1; -; mRNA.
DR   EMBL; AJ222813; CAA11001.1; -; mRNA.
DR   EMBL; AY258448; AAP14669.1; -; mRNA.
DR   EMBL; AY077842; AAL77211.1; -; mRNA.
DR   RefSeq; NP_062038.1; NM_019165.1. [P97636-1]
DR   UniGene; Rn.11118; -.
DR   ProteinModelPortal; P97636; -.
DR   SMR; P97636; 37-190.
DR   STRING; 10116.ENSRNOP00000013093; -.
DR   PaxDb; P97636; -.
DR   GeneID; 29197; -.
DR   KEGG; rno:29197; -.
DR   UCSC; RGD:2889; rat. [P97636-1]
DR   CTD; 3606; -.
DR   RGD; 2889; Il18.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   HOGENOM; HOG000048723; -.
DR   HOVERGEN; HBG000388; -.
DR   InParanoid; P97636; -.
DR   KO; K05482; -.
DR   PhylomeDB; P97636; -.
DR   TreeFam; TF336297; -.
DR   PRO; PR:P97636; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR   GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR   GO; GO:0071320; P:cellular response to cAMP; IEP:RGD.
DR   GO; GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IEP:RGD.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:RGD.
DR   GO; GO:0071374; P:cellular response to parathyroid hormone stimulus; IEP:RGD.
DR   GO; GO:0071375; P:cellular response to peptide hormone stimulus; IMP:RGD.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IDA:RGD.
DR   GO; GO:0048546; P:digestive tract morphogenesis; IEP:RGD.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0007611; P:learning or memory; TAS:RGD.
DR   GO; GO:0030324; P:lung development; IEP:RGD.
DR   GO; GO:0033030; P:negative regulation of neutrophil apoptotic process; IMP:RGD.
DR   GO; GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:RGD.
DR   GO; GO:0001649; P:osteoblast differentiation; IEP:RGD.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
DR   GO; GO:2000504; P:positive regulation of blood vessel remodeling; IDA:RGD.
DR   GO; GO:0032722; P:positive regulation of chemokine production; IMP:RGD.
DR   GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:RGD.
DR   GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEP:RGD.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IDA:RGD.
DR   GO; GO:2000256; P:positive regulation of male germ cell proliferation; IDA:RGD.
DR   GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
DR   GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
DR   GO; GO:0032930; P:positive regulation of superoxide anion generation; IMP:RGD.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IMP:RGD.
DR   GO; GO:0043117; P:positive regulation of vascular permeability; IMP:RGD.
DR   GO; GO:0030155; P:regulation of cell adhesion; ISS:UniProtKB.
DR   GO; GO:0045188; P:regulation of circadian sleep/wake cycle, non-REM sleep; TAS:UniProtKB.
DR   GO; GO:0009409; P:response to cold; IEP:RGD.
DR   GO; GO:0055093; P:response to hyperoxia; IEP:RGD.
DR   GO; GO:0001666; P:response to hypoxia; IMP:RGD.
DR   GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
DR   GO; GO:0009314; P:response to radiation; IEP:RGD.
DR   GO; GO:0030431; P:sleep; IDA:UniProtKB.
DR   GO; GO:0042088; P:T-helper 1 type immune response; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Cytokine; Reference proteome;
KW   Secreted.
FT   PROPEP        1     36       {ECO:0000250}.
FT                                /FTId=PRO_0000015349.
FT   CHAIN        37    194       Interleukin-18.
FT                                /FTId=PRO_0000015350.
FT   VAR_SEQ     121    139       Missing (in isoform Alpha).
FT                                {ECO:0000303|PubMed:8999896}.
FT                                /FTId=VSP_002659.
FT   CONFLICT      4      5       MS -> IP (in Ref. 2; CAA11001 and 4;
FT                                AAL77211). {ECO:0000305}.
FT   CONFLICT     48     48       I -> M (in Ref. 2; CAA11001 and 4;
FT                                AAL77211). {ECO:0000305}.
SQ   SEQUENCE   194 AA;  22303 MW;  E2089AD6F1798450 CRC64;
     MAAMSEEGSC VNFKEMMFID NTLYLIPEDN GDLESDHFGR LHCTTAVIRS INDQVLFVDK
     RNPPVFEDMP DIDRTANESQ TRLIIYMYKD SEVRGLAVTL SVKDGRMSTL SCKNKIISFE
     EMNPPENIDD IKSDLIFFQK RVPGHNKMEF ESSLYEGHFL ACQKEDDAFK LVLKRKDENG
     DKSVMFTLTN LHQS
//
ID   IL1A_BOVIN              Reviewed;         268 AA.
AC   P08831;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   08-JUN-2016, entry version 121.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   Flags: Precursor;
GN   Name=IL1A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3262865; DOI=10.1093/nar/16.18.9053;
RA   Leong S.R., Flaggs G.M., Lawman M., Gray P.W.;
RT   "The nucleotide sequence for the cDNA of bovine interleukin-1 alpha.";
RL   Nucleic Acids Res. 16:9053-9053(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3261832; DOI=10.1016/0161-5890(88)90162-9;
RA   Maliszewski C.R., Baker P.E., Schoenborn M.A., Davis B.S., Cosman D.,
RA   Gillis S., Cerretti D.P.;
RT   "Cloning, sequence and expression of bovine interleukin 1 alpha and
RT   interleukin 1 beta complementary DNAs.";
RL   Mol. Immunol. 25:429-437(1988).
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; M36182; AAA30590.1; -; mRNA.
DR   EMBL; X12497; CAA31017.1; -; mRNA.
DR   EMBL; M37210; AAA30583.1; -; mRNA.
DR   PIR; JL0009; ICBO1A.
DR   RefSeq; NP_776517.1; NM_174092.1.
DR   UniGene; Bt.191; -.
DR   ProteinModelPortal; P08831; -.
DR   STRING; 9913.ENSBTAP00000013665; -.
DR   PaxDb; P08831; -.
DR   Ensembl; ENSBTAT00000013665; ENSBTAP00000013665; ENSBTAG00000010349.
DR   GeneID; 281250; -.
DR   KEGG; bta:281250; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; P08831; -.
DR   KO; K04383; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-BTA-446652; Interleukin-1 signaling.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    112
FT                                /FTId=PRO_0000015251.
FT   CHAIN       113    268       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015252.
FT   MOD_RES      87     87       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   CARBOHYD    102    102       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    141    141       N-linked (GlcNAc...). {ECO:0000255}.
SQ   SEQUENCE   268 AA;  30833 MW;  FCA914210DF864AE CRC64;
     MAKVPDLFED LKNCYSENED YSSEIDHLSL NQKSFYDASY EPLREDQMNK FMSLDTSETS
     KTSKLSFKEN VVMVAASGKI LKKRRLSLNQ FITDDDLEAI ANNTEEEIIK PRSAHYSFQS
     NVKYNFMRVI HQECILNDAL NQSIIRDMSG PYLTATTLNN LEEAVKFDMV AYVSEEDSQL
     PVTLRISKTQ LFVSAQNEDE PVLLKEMPET PKIIKDETNL LFFWEKHGSM DYFKSVAHPK
     LFIATKQEKL VHMASGPPSI TDFQILEK
//
ID   IL1A_CANLF              Reviewed;         265 AA.
AC   O46612; Q006K7;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   08-JUN-2016, entry version 107.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   Flags: Precursor;
GN   Name=IL1A;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10452947; DOI=10.1016/S0378-1119(99)00274-7;
RA   Straubinger A.F., Viveiros M.M., Straubinger R.K.;
RT   "Identification of two transcripts of canine, feline, and porcine
RT   interleukin-1 alpha.";
RL   Gene 236:273-280(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Soller J.T., Murua Escobar H., Janssen M., Fork M., Bullerdiek J.,
RA   Nolte I.;
RT   "Cytokine gene single nucleotide polymorphism (SNP) screening analyses
RT   in canine malignant histiocytosis.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; AF047011; AAC03066.1; -; mRNA.
DR   EMBL; DQ923806; ABJ51907.1; -; mRNA.
DR   RefSeq; NP_001003157.2; NM_001003157.2.
DR   UniGene; Cfa.3645; -.
DR   ProteinModelPortal; O46612; -.
DR   STRING; 9615.ENSCAFP00000038305; -.
DR   PaxDb; O46612; -.
DR   GeneID; 403782; -.
DR   KEGG; cfa:403782; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; O46612; -.
DR   KO; K04383; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    108       {ECO:0000250}.
FT                                /FTId=PRO_0000015253.
FT   CHAIN       109    265       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015254.
FT   MOD_RES      83     83       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   CARBOHYD     98     98       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    137    137       N-linked (GlcNAc...). {ECO:0000255}.
FT   CONFLICT     95     95       G -> D (in Ref. 2; ABJ51907).
FT                                {ECO:0000305}.
SQ   SEQUENCE   265 AA;  30522 MW;  CC1D316CA37173A8 CRC64;
     MAKVPDLFED LKNCYSENEE YSSEIDHLSL NQKSFYDMSC DPLHEDCMSL STSEISKTSQ
     LTFKENVVVV AANGKILKKR RLSLSQFITD DDLEGIANDT EEVIMKPRSV AYNFHNNEKY
     NYIRIIKSQF ILNDNLNQSI VRQTGGNYLM TAALQNLDDA VKFDMGAYTS EDSKLPVTLR
     ISKTRLFVSA QNEDEPVLLK EMPETPKTIR DETNLLFFWE RHGSKHYFKS VAQPKLFIAT
     QERKLVHMAR GQPSITDFRL LETQP
//
ID   IL1A_CAVPO              Reviewed;         204 AA.
AC   Q60480;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   11-NOV-2015, entry version 84.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   Flags: Precursor; Fragment;
GN   Name=IL1A;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hartley; TISSUE=Lung;
RA   Yuan H.T., Kelly F.J., Bingle C.D.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
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CC   -----------------------------------------------------------------------
DR   EMBL; U46778; AAA87591.1; -; mRNA.
DR   ProteinModelPortal; Q60480; -.
DR   STRING; 10141.ENSCPOP00000016482; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; Q60480; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP       <1    110       {ECO:0000250}.
FT                                /FTId=PRO_0000015257.
FT   CHAIN       111   >204       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015258.
FT   MOD_RES      85     85       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   CARBOHYD     57     57       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD     87     87       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    100    100       N-linked (GlcNAc...). {ECO:0000255}.
FT   NON_TER       1      1
FT   NON_TER     204    204
SQ   SEQUENCE   204 AA;  23333 MW;  6AA25A71D90B7E9C CRC64;
     FEDLKNCYSE NEEYASAIDH LSLNQKSFYD TNYDPLHENR VDEPVSPNPY ENSEESNFTL
     EDSSDSSAVV LTSAHGEVLK KRRLSLNQTM SNEDLEAIAN DSEEEIIEPW SVPYSFQSNL
     KFKYQRSIKK GAVITDAMHQ SLIRESNGQH LKAMHVVDRK HEVKFDIDGY VSTATRIRPV
     TLKISKTQLY VCAQEEGQPV LLKE
//
ID   IL1A_FELCA              Reviewed;         270 AA.
AC   O46613;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   08-JUN-2016, entry version 97.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   Flags: Precursor;
GN   Name=IL1A;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10452947; DOI=10.1016/S0378-1119(99)00274-7;
RA   Straubinger A.F., Viveiros M.M., Straubinger R.K.;
RT   "Identification of two transcripts of canine, feline, and porcine
RT   interleukin-1 alpha.";
RL   Gene 236:273-280(1999).
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF047012; AAC03067.1; -; mRNA.
DR   RefSeq; NP_001009351.1; NM_001009351.1.
DR   ProteinModelPortal; O46613; -.
DR   STRING; 9685.ENSFCAP00000007503; -.
DR   GeneID; 493944; -.
DR   KEGG; fca:493944; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; O46613; -.
DR   KO; K04383; -.
DR   OrthoDB; EOG76473H; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    112       {ECO:0000250}.
FT                                /FTId=PRO_0000015261.
FT   CHAIN       113    270       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015262.
FT   MOD_RES      87     87       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   CARBOHYD    139    139       N-linked (GlcNAc...). {ECO:0000255}.
SQ   SEQUENCE   270 AA;  30798 MW;  1A43E1798B523556 CRC64;
     MAKVPDLFED LKNCYSENEE YSSEIDHLTL NQKSFYDASY DPLHEDCTDK FMSPSTSETS
     KTPQLTLKKS VVMVAANGKI LKKRRLSLNQ FLTADDLEAI ANEVEEEIMK PRSVAPNFYS
     SEKYNYQKII KSQFILNDNL SQSVIRKAGG KYLAAAALQN LDDAVKFDMG AYTSKEDSKL
     PVTLRISKTR LFVSAQNEDE PVLLKEMPET PKTIRDETNL LFFWERHGSK NYFKSVAHPK
     LFIATQEEQL VHMARGLPSV TDFQILETQS
//
ID   IL1A_HORSE              Reviewed;         270 AA.
AC   Q28385; O77743;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   08-JUN-2016, entry version 104.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   Flags: Precursor;
GN   Name=IL1A;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8578682; DOI=10.1016/0165-2427(95)05441-8;
RA   Kato H., Ohashi T., Nakamura N., Nishimura Y., Watari T., Goitsuka R.,
RA   Tsujimoto H., Hasegawa A.;
RT   "Molecular cloning of equine interleukin-1 alpha and -beta cDNAs.";
RL   Vet. Immunol. Immunopathol. 48:221-231(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9622738;
RA   Howard R.D., McIlwraith C.W., Trotter G.W., Nyborg J.K.;
RT   "Cloning of equine interleukin-1 alpha and equine interleukin-1 beta
RT   and determination of their full-length cDNA sequences.";
RL   Am. J. Vet. Res. 59:704-711(1998).
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; D42146; BAA07717.1; -; mRNA.
DR   EMBL; U92480; AAC39255.1; -; mRNA.
DR   RefSeq; NP_001075969.2; NM_001082500.2.
DR   UniGene; Eca.13125; -.
DR   ProteinModelPortal; Q28385; -.
DR   STRING; 9796.ENSECAP00000021137; -.
DR   PaxDb; Q28385; -.
DR   GeneID; 100064969; -.
DR   KEGG; ecb:100064969; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; Q28385; -.
DR   KO; K04383; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    112       {ECO:0000250}.
FT                                /FTId=PRO_0000015263.
FT   CHAIN       113    270       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015264.
FT   MOD_RES      87     87       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   CARBOHYD    141    141       N-linked (GlcNAc...). {ECO:0000255}.
FT   CONFLICT    110    110       R -> K (in Ref. 2; AAC39255).
FT                                {ECO:0000305}.
FT   CONFLICT    150    150       G -> V (in Ref. 2; AAC39255).
FT                                {ECO:0000305}.
SQ   SEQUENCE   270 AA;  30807 MW;  381859713754DB90 CRC64;
     MAKVPDLFED LKNCYSENED YSSEIDHLSL TQKSFYDASY DPLPEDCMDT FMSLSTSETS
     KTSKLNFKES VVLVAANGKT LKKRRLSLNQ FITNDDLEAI ANDPEEGIIR PRSVHYNFQS
     NTKYNFMRIV NHQCTLNDAL NQSVIRDTSG QYLATAALNN LDDAVKFDMG AYTSEEDSQL
     PVTLRISKTR LFVSAQNEDE PVLLKEMPDT PKTIKDETNL LFFWERHGSK NYFKSVAHPK
     LFIATKQGKL VHMARGQPSI TDFQILDNQF
//
ID   IL1A_HUMAN              Reviewed;         271 AA.
AC   P01583; Q53QF9; Q7RU02;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   06-JUL-2016, entry version 184.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   AltName: Full=Hematopoietin-1;
DE   Flags: Precursor;
GN   Name=IL1A; Synonyms=IL1F1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2989698; DOI=10.1038/315641a0;
RA   March C.J., Mosley B., Larsen A., Cerretti D.P., Braedt G., Price V.,
RA   Gillis S., Henney C.S., Kronheim S.R., Grabstein K., Conlon P.J.,
RA   Hopp T.P., Cosman D.;
RT   "Cloning, sequence and expression of two distinct human interleukin-1
RT   complementary DNAs.";
RL   Nature 315:641-647(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3486405; DOI=10.1093/nar/14.8.3167;
RA   Furutani Y., Notake M., Fukui T., Ohue M., Nomura H., Yamada M.,
RA   Nakamura S.;
RT   "Complete nucleotide sequence of the gene for human interleukin 1
RT   alpha.";
RL   Nucleic Acids Res. 14:3167-3179(1986).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-114.
RX   PubMed=2994016; DOI=10.1093/nar/13.16.5869;
RA   Furutani Y., Notake M., Yamayoshi M., Yamagishi J., Nomura H.,
RA   Ohue M., Furuta R., Fukui T., Yamada M., Nakamura S.;
RT   "Cloning and characterization of the cDNAs for human and rabbit
RT   interleukin-1 precursor.";
RL   Nucleic Acids Res. 13:5869-5882(1985).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-114.
RX   PubMed=2635664;
RA   Kotenko S.V., Bulenkov M.T., Veiko V.P., Epishin S.M., Lomakin I.B.,
RA   Emel'Yanov A.V., Kozlov A.P., Konusova V.G., Kotov A.Y.,
RA   Kurbatova T.V., Reshetnikov V.L., Simbirtsev A.S., Ketlinskii S.A.,
RA   Vinetskii Y.P.;
RT   "Cloning of the cDNA coding for human prointerleukin-1 alpha and
RT   prointerleukin-1 beta.";
RL   Dokl. Akad. Nauk SSSR 309:1005-1008(1989).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3485152;
RA   Gubler U., Chua A.O., Stern A.S., Hellmann C.P., Vitek M.P.,
RA   Dechiara T.M., Benjamin W.R., Collier K.J., Dukovich M.,
RA   Familletti P.C., Fiedler-Nagy C., Jenson J., Kaffka K., Kilian P.L.,
RA   Stremlo D., Wittreich B.H., Woehle D., Mizel S.B., Lomedico P.T.;
RT   "Recombinant human interleukin 1 alpha: purification and biological
RT   characterization.";
RL   J. Immunol. 136:2492-2497(1986).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3493774;
RA   Nishida T., Nishino N., Takano M., Kawai K., Bando K., Masui Y.,
RA   Nakai S., Hirai Y.;
RT   "cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell
RT   line.";
RL   Biochem. Biophys. Res. Commun. 143:345-352(1987).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLN-85; SER-114 AND
RP   ASN-138.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN   [11]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [12]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [13]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [14]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [15]
RP   PROTEIN SEQUENCE OF 113-132.
RX   PubMed=3281727;
RA   Zsebo K.M., Wypych J., Yuschenkoff V.N., Lu H., Hunt P., Dukes P.P.,
RA   Langley K.E.;
RT   "Effects of hematopoietin-1 and interleukin 1 activities on early
RT   hematopoietic cells of the bone marrow.";
RL   Blood 71:962-968(1988).
RN   [16]
RP   MYRISTOYLATION AT LYS-82 AND LYS-83.
RX   PubMed=8346241; DOI=10.1073/pnas.90.15.7245;
RA   Stevenson F.T., Bursten S.L., Fanton C., Locksley R.M., Lovett D.H.;
RT   "The 31-kDa precursor of interleukin 1 alpha is myristoylated on
RT   specific lysines within the 16-kDa N-terminal propiece.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:7245-7249(1993).
RN   [17]
RP   X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
RX   PubMed=2346741; DOI=10.1021/bi00463a009;
RA   Graves B.J., Hatada M.H., Hendrickson W.A., Miller J.K., Madison V.S.,
RA   Satow Y.;
RT   "Structure of interleukin 1 alpha at 2.7-A resolution.";
RL   Biochemistry 29:2679-2684(1990).
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells.
CC   -!- SUBUNIT: Monomer.
CC   -!- INTERACTION:
CC       P29466:CASP1; NbExp=3; IntAct=EBI-1749782, EBI-516667;
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="https://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1a/";
CC   -!- WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and
CC       polymorphism database;
CC       URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1A";
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CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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DR   EMBL; X02531; CAA26371.1; -; mRNA.
DR   EMBL; X03833; CAA27448.1; -; Genomic_DNA.
DR   EMBL; X02851; CAA26604.1; -; mRNA.
DR   EMBL; X56086; CAA39566.1; -; mRNA.
DR   EMBL; M28983; AAA59134.1; -; mRNA.
DR   EMBL; M15329; AAA59133.1; -; mRNA.
DR   EMBL; BN000002; CAD29871.1; -; Genomic_DNA.
DR   EMBL; BT007014; AAP35660.1; -; mRNA.
DR   EMBL; CR457414; CAG33695.1; -; mRNA.
DR   EMBL; AF536338; AAM96189.1; -; Genomic_DNA.
DR   EMBL; AK314850; BAG37367.1; -; mRNA.
DR   EMBL; AC112235; AAX93054.1; -; Genomic_DNA.
DR   EMBL; CH471217; EAW73604.1; -; Genomic_DNA.
DR   EMBL; BC013142; AAH13142.1; -; mRNA.
DR   CCDS; CCDS2101.1; -.
DR   PIR; A23385; ICHU1A.
DR   RefSeq; NP_000566.3; NM_000575.4.
DR   UniGene; Hs.1722; -.
DR   PDB; 1ITA; Model; -; A=121-271.
DR   PDB; 2ILA; X-ray; 2.30 A; A=117-271.
DR   PDB; 2KKI; NMR; -; A=121-271.
DR   PDB; 2L5X; NMR; -; A/D=121-271.
DR   PDBsum; 1ITA; -.
DR   PDBsum; 2ILA; -.
DR   PDBsum; 2KKI; -.
DR   PDBsum; 2L5X; -.
DR   ProteinModelPortal; P01583; -.
DR   SMR; P01583; 121-271.
DR   BioGrid; 109768; 13.
DR   DIP; DIP-40550N; -.
DR   IntAct; P01583; 4.
DR   MINT; MINT-1534764; -.
DR   STRING; 9606.ENSP00000263339; -.
DR   DrugBank; DB06372; Rilonacept.
DR   iPTMnet; P01583; -.
DR   PhosphoSite; P01583; -.
DR   BioMuta; IL1A; -.
DR   DMDM; 124297; -.
DR   EPD; P01583; -.
DR   PaxDb; P01583; -.
DR   PeptideAtlas; P01583; -.
DR   PRIDE; P01583; -.
DR   DNASU; 3552; -.
DR   Ensembl; ENST00000263339; ENSP00000263339; ENSG00000115008.
DR   GeneID; 3552; -.
DR   KEGG; hsa:3552; -.
DR   UCSC; uc002tig.4; human.
DR   CTD; 3552; -.
DR   GeneCards; IL1A; -.
DR   HGNC; HGNC:5991; IL1A.
DR   HPA; HPA048546; -.
DR   MIM; 147760; gene.
DR   neXtProt; NX_P01583; -.
DR   PharmGKB; PA29807; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; P01583; -.
DR   KO; K04383; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   PhylomeDB; P01583; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-HSA-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR   Reactome; R-HSA-446652; Interleukin-1 signaling.
DR   Reactome; R-HSA-448706; Interleukin-1 processing.
DR   SignaLink; P01583; -.
DR   SIGNOR; P01583; -.
DR   ChiTaRS; IL1A; human.
DR   EvolutionaryTrace; P01583; -.
DR   GeneWiki; IL1A; -.
DR   GenomeRNAi; 3552; -.
DR   PMAP-CutDB; P01583; -.
DR   PRO; PR:P01583; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; P01583; -.
DR   CleanEx; HS_IL1A; -.
DR   Genevisible; P01583; HS.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; IDA:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IMP:BHF-UCL.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
DR   GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
DR   GO; GO:0034605; P:cellular response to heat; IDA:UniProtKB.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; TAS:ProtInc.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; TAS:BHF-UCL.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISS:BHF-UCL.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IDA:BHF-UCL.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IMP:BHF-UCL.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IMP:BHF-UCL.
DR   GO; GO:0050714; P:positive regulation of protein secretion; IMP:AgBase.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; ISS:BHF-UCL.
DR   GO; GO:0046688; P:response to copper ion; IDA:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytokine; Direct protein sequencing;
KW   Glycoprotein; Inflammatory response; Lipoprotein; Mitogen; Myristate;
KW   Phosphoprotein; Polymorphism; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    112       {ECO:0000269|PubMed:3281727}.
FT                                /FTId=PRO_0000015265.
FT   CHAIN       113    271       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015266.
FT   MOD_RES      87     87       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   LIPID        82     82       N6-myristoyl lysine.
FT                                {ECO:0000269|PubMed:8346241}.
FT   LIPID        83     83       N6-myristoyl lysine.
FT                                {ECO:0000269|PubMed:8346241}.
FT   CARBOHYD    102    102       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    141    141       N-linked (GlcNAc...). {ECO:0000255}.
FT   VARIANT      85     85       R -> Q (in dbSNP:rs3783531).
FT                                {ECO:0000269|Ref.10}.
FT                                /FTId=VAR_014304.
FT   VARIANT     114    114       A -> S (in dbSNP:rs17561).
FT                                {ECO:0000269|PubMed:2635664,
FT                                ECO:0000269|PubMed:2994016,
FT                                ECO:0000269|Ref.10}.
FT                                /FTId=VAR_014305.
FT   VARIANT     125    125       N -> D (in dbSNP:rs17562).
FT                                /FTId=VAR_014600.
FT   VARIANT     138    138       D -> N (in dbSNP:rs3783581).
FT                                {ECO:0000269|Ref.10}.
FT                                /FTId=VAR_014306.
FT   VARIANT     176    176       D -> H (in dbSNP:rs1801715).
FT                                /FTId=VAR_014601.
FT   STRAND      124    137       {ECO:0000244|PDB:2KKI}.
FT   STRAND      143    150       {ECO:0000244|PDB:2KKI}.
FT   STRAND      152    155       {ECO:0000244|PDB:2KKI}.
FT   STRAND      158    160       {ECO:0000244|PDB:2KKI}.
FT   STRAND      165    172       {ECO:0000244|PDB:2KKI}.
FT   STRAND      176    178       {ECO:0000244|PDB:2KKI}.
FT   STRAND      181    189       {ECO:0000244|PDB:2KKI}.
FT   STRAND      192    194       {ECO:0000244|PDB:2KKI}.
FT   STRAND      198    200       {ECO:0000244|PDB:2KKI}.
FT   STRAND      203    205       {ECO:0000244|PDB:2KKI}.
FT   STRAND      212    214       {ECO:0000244|PDB:2KKI}.
FT   HELIX       216    221       {ECO:0000244|PDB:2KKI}.
FT   STRAND      223    228       {ECO:0000244|PDB:2KKI}.
FT   STRAND      231    235       {ECO:0000244|PDB:2KKI}.
FT   STRAND      242    244       {ECO:0000244|PDB:2KKI}.
FT   STRAND      248    251       {ECO:0000244|PDB:2KKI}.
FT   STRAND      259    261       {ECO:0000244|PDB:2KKI}.
FT   STRAND      264    267       {ECO:0000244|PDB:2KKI}.
SQ   SEQUENCE   271 AA;  30607 MW;  CBCCC49569D9ED40 CRC64;
     MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ SVSLSISETS
     KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI ANDSEEEIIK PRSAPFSFLS
     NVKYNFMRII KYEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI
     TVILRISKTQ LYVTAQDEDQ PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP
     NLFIATKQDY WVCLAGGPPS ITDFQILENQ A
//
ID   IL1A_MACMU              Reviewed;         271 AA.
AC   P48089;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   08-JUN-2016, entry version 94.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   AltName: Full=Hematopoietin-1;
DE   Flags: Precursor;
GN   Name=IL1A;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   PubMed=7561102;
RA   Villinger F.J., Brar S.S., Mayne A.E., Chikkala N., Ansari A.A.;
RT   "Comparative sequence analysis of cytokine genes from human and
RT   nonhuman primates.";
RL   J. Immunol. 155:3946-3954(1995).
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
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DR   EMBL; U19844; AAA86708.1; -; mRNA.
DR   RefSeq; NP_001036222.1; NM_001042757.1.
DR   UniGene; Mmu.3361; -.
DR   ProteinModelPortal; P48089; -.
DR   STRING; 9544.ENSMMUP00000026006; -.
DR   GeneID; 700193; -.
DR   KEGG; mcc:700193; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; P48089; -.
DR   KO; K04383; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    112       {ECO:0000250}.
FT                                /FTId=PRO_0000015271.
FT   CHAIN       113    271       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015272.
FT   MOD_RES      87     87       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   CARBOHYD    102    102       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    121    121       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    137    137       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    141    141       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    211    211       N-linked (GlcNAc...). {ECO:0000255}.
SQ   SEQUENCE   271 AA;  30693 MW;  1DB6BC7C5E5B438E CRC64;
     MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYDVSY GPLHEGCMDQ SVSLSISEIS
     KTSKLTFKQS MVVVSTNGKV LKKRRLSLSQ SITDNNLEAI ANDSEEEIIK PRSAPFSFLS
     NMTYHFIRII KHEFILNDTL NQTIIRANDQ HLTAAAIHNL DEAVKFDMGA YTSSKDDTKV
     PVILRISKTQ LYVSAQDEDQ PVLLKEMPEI NKTITGSETN FLFFWETHGT KNYFISVAHP
     NLFIATKHDN WVCLAKGLPS ITDFQILENQ A
//
ID   IL1A_MOUSE              Reviewed;         270 AA.
AC   P01582;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   06-JUL-2016, entry version 146.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   Flags: Precursor;
GN   Name=Il1a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6209582; DOI=10.1038/312458a0;
RA   Lomedico P.T., Gubler U., Hellmann C.P., Dukovich M., Giri J.G.,
RA   Pan Y.-C.E., Collier K., Semionow R., Chua A.O., Mizel S.B.;
RT   "Cloning and expression of murine interleukin-1 cDNA in Escherichia
RT   coli.";
RL   Nature 312:458-462(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BALB/cJ;
RA   Kastelic T., Wanner A., Mackenzie A., Cheneval D.;
RT   "Complete nucleotide sequence of the murine interleukin-1 alpha
RT   gene.";
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION AT SER-90.
RX   PubMed=3126184;
RA   Beuscher H.U., Nickells M.W., Colten H.R.;
RT   "The precursor of interleukin-1 alpha is phosphorylated at residue
RT   serine 90.";
RL   J. Biol. Chem. 263:4023-4028(1988).
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; X01450; CAA25682.1; -; mRNA.
DR   EMBL; AF010237; AAC28999.1; -; Genomic_DNA.
DR   EMBL; BC003727; AAH03727.1; -; mRNA.
DR   CCDS; CCDS16725.1; -.
DR   PIR; A01846; ICMS1.
DR   RefSeq; NP_034684.2; NM_010554.4.
DR   RefSeq; XP_006498856.1; XM_006498793.2.
DR   UniGene; Mm.15534; -.
DR   ProteinModelPortal; P01582; -.
DR   SMR; P01582; 123-269.
DR   BioGrid; 200623; 1.
DR   STRING; 10090.ENSMUSP00000028882; -.
DR   iPTMnet; P01582; -.
DR   PhosphoSite; P01582; -.
DR   PaxDb; P01582; -.
DR   PRIDE; P01582; -.
DR   Ensembl; ENSMUST00000028882; ENSMUSP00000028882; ENSMUSG00000027399.
DR   GeneID; 16175; -.
DR   KEGG; mmu:16175; -.
DR   UCSC; uc008mhr.1; mouse.
DR   CTD; 3552; -.
DR   MGI; MGI:96542; Il1a.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; P01582; -.
DR   KO; K04383; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   PhylomeDB; P01582; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-MMU-446652; Interleukin-1 signaling.
DR   PRO; PR:P01582; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; P01582; -.
DR   CleanEx; MM_IL1A; -.
DR   ExpressionAtlas; P01582; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IPI:MGI.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IMP:MGI.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:MGI.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IGI:MGI.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IMP:MGI.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IDA:MGI.
DR   GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IDA:MGI.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; ISO:MGI.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; ISO:MGI.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IDA:MGI.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IDA:MGI.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; ISO:MGI.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IDA:MGI.
DR   GO; GO:2000391; P:positive regulation of neutrophil extravasation; IDA:MGI.
DR   GO; GO:0050714; P:positive regulation of protein secretion; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IMP:BHF-UCL.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    114
FT                                /FTId=PRO_0000015273.
FT   CHAIN       115    270       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015274.
FT   MOD_RES      90     90       Phosphoserine.
FT                                {ECO:0000269|PubMed:3126184}.
FT   CARBOHYD     64     64       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    139    139       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    143    143       N-linked (GlcNAc...). {ECO:0000255}.
SQ   SEQUENCE   270 AA;  31023 MW;  7F60AC4F330D5B11 CRC64;
     MAKVPDLFED LKNCYSENED YSSAIDHLSL NQKSFYDASY GSLHETCTDQ FVSLRTSETS
     KMSNFTFKES RVTVSATSSN GKILKKRRLS FSETFTEDDL QSITHDLEET IQPRSAPYTY
     QSDLRYKLMK LVRQKFVMND SLNQTIYQDV DKHYLSTTWL NDLQQEVKFD MYAYSSGGDD
     SKYPVTLKIS DSQLFVSAQG EDQPVLLKEL PETPKLITGS ETDLIFFWKS INSKNYFTSA
     AYPELFIATK EQSRVHLARG LPSMTDFQIS
//
ID   IL1A_PIG                Reviewed;         270 AA.
AC   P18430;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   08-JUN-2016, entry version 112.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   Flags: Precursor;
GN   Name=IL1A;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RX   PubMed=2377484; DOI=10.1093/nar/18.14.4282;
RA   Maliszewski C.R., Renshaw B.R., Schoenborn M.A., Urban J.F. Jr.,
RA   Baker P.E.;
RT   "Porcine IL-1 alpha cDNA nucleotide sequence.";
RL   Nucleic Acids Res. 18:4282-4282(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huether M.J., Scamurra R.W., Murtaugh M.P., Molitor T.W.;
RT   "Cloning and sequencing of a cDNA encoding porcine interleukin-1
RT   alpha.";
RL   Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; X52731; CAA36945.1; -; mRNA.
DR   EMBL; M86730; AAA73198.1; -; mRNA.
DR   PIR; I46620; I46620.
DR   PIR; S10532; S10532.
DR   RefSeq; NP_999194.1; NM_214029.1.
DR   RefSeq; XP_005655255.1; XM_005655198.2.
DR   RefSeq; XP_013843310.1; XM_013987856.1.
DR   UniGene; Ssc.113; -.
DR   ProteinModelPortal; P18430; -.
DR   STRING; 9823.ENSSSCP00000008638; -.
DR   PaxDb; P18430; -.
DR   Ensembl; ENSSSCT00000008863; ENSSSCP00000008638; ENSSSCG00000008090.
DR   GeneID; 397094; -.
DR   KEGG; ssc:397094; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; P18430; -.
DR   KO; K04383; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-SSC-446652; Interleukin-1 signaling.
DR   Proteomes; UP000008227; Chromosome 3.
DR   Genevisible; P18430; SS.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    112
FT                                /FTId=PRO_0000015275.
FT   CHAIN       113    270       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015276.
FT   MOD_RES      87     87       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   CARBOHYD    102    102       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    141    141       N-linked (GlcNAc...). {ECO:0000255}.
FT   CONFLICT     89     89       N -> I (in Ref. 2; AAA73198).
FT                                {ECO:0000305}.
FT   CONFLICT    242    242       F -> L (in Ref. 2; AAA73198).
FT                                {ECO:0000305}.
FT   CONFLICT    255    255       P -> R (in Ref. 2; AAA73198).
FT                                {ECO:0000305}.
SQ   SEQUENCE   270 AA;  30789 MW;  5677BF2B0EF63839 CRC64;
     MAKVPDLFED LKNCYSENEE YSSDIDHLSL NQKSFYDASY EPLPGDGMDK FMPLSTSKTS
     KTSRLNFKDS VVMAAANGKI LKKRRLSLNQ FITDDDLEAI ANDTEEEIIK PRSATYSFQS
     NMKYNFMRVI NHQCILNDAR NQSIIRDPSG QYLMAAVLNN LDEAVKFDMA AYTSNDDSQL
     PVTLRISETR LFVSAQNEDE PVLLKELPET PKTIKDETSL LFFWEKHGNM DYFKSAAHPK
     LFIATRQEKL VHMAPGLPSV TDFQILENQS
//
ID   IL1A_RABIT              Reviewed;         267 AA.
AC   P04822;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   11-NOV-2015, entry version 103.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   Flags: Precursor;
GN   Name=IL1A;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2994016; DOI=10.1093/nar/13.16.5869;
RA   Furutani Y., Notake M., Yamayoshi M., Yamagishi J., Nomura H.,
RA   Ohue M., Furuta R., Fukui T., Yamada M., Nakamura S.;
RT   "Cloning and characterization of the cDNAs for human and rabbit
RT   interleukin-1 precursor.";
RL   Nucleic Acids Res. 13:5869-5882(1985).
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; X02852; CAA26605.1; -; mRNA.
DR   PIR; B24073; B24073.
DR   RefSeq; NP_001095154.1; NM_001101684.1.
DR   UniGene; Ocu.2080; -.
DR   ProteinModelPortal; P04822; -.
DR   STRING; 9986.ENSOCUP00000007573; -.
DR   Ensembl; ENSOCUT00000008771; ENSOCUP00000007573; ENSOCUG00000008771.
DR   GeneID; 100009250; -.
DR   KEGG; ocu:100009250; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; P04822; -.
DR   KO; K04383; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001811; Chromosome 2.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    112
FT                                /FTId=PRO_0000015277.
FT   CHAIN       113    267       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015278.
FT   MOD_RES      87     87       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   CARBOHYD     64     64       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    100    100       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    141    141       N-linked (GlcNAc...). {ECO:0000255}.
SQ   SEQUENCE   267 AA;  30375 MW;  6D20533FD1FA4822 CRC64;
     MAKVPDLFED LKNCFSENEE YSSAIDHLSL NQKSFYDASY EPLHEDCMNK VVSLSTSETS
     VSPNLTFQEN VVAVTASGKI LKKRRLSLNQ PITDVDLETN VSDPEEGIIK PRSVPYTFQR
     NMRYKYLRII KQEFTLNDAL NQSLVRDTSD QYLRAAPLQN LGDAVKFDMG VYMTSEDSIL
     PVTLRISQTP LFVSAQNEDE PVLLKEMPET PRIITDSESD ILFFWETQGN KNYFKSAANP
     QLFIATKPEH LVHMARGLPS MTDFQIS
//
ID   IL1A_RAT                Reviewed;         270 AA.
AC   P16598; Q546R9;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   06-JUL-2016, entry version 122.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   Flags: Precursor;
GN   Name=Il1a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2471704;
RA   Nishida T., Nishino N., Takano M., Sekiguchi Y., Kawai K., Mizuno K.,
RA   Nakai S., Masui Y., Hirai Y.;
RT   "Molecular cloning and expression of rat interleukin-1 alpha cDNA.";
RL   J. Biochem. 105:351-357(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Testis;
RA   Sultana T., Svechnikov K., Weber G., Soeder O.;
RT   "Production of recombinant rat testis interleukin-1 alpha precursor
RT   form and discovery of a novel splice version lacking the calpain
RT   cleavage site.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; D00403; BAA00306.1; -; mRNA.
DR   EMBL; AJ245642; CAC03995.1; -; mRNA.
DR   PIR; JX0064; JX0064.
DR   RefSeq; NP_058715.1; NM_017019.1.
DR   UniGene; Rn.12300; -.
DR   ProteinModelPortal; P16598; -.
DR   STRING; 10116.ENSRNOP00000006113; -.
DR   BindingDB; P16598; -.
DR   PaxDb; P16598; -.
DR   PRIDE; P16598; -.
DR   GeneID; 24493; -.
DR   KEGG; rno:24493; -.
DR   UCSC; RGD:2890; rat.
DR   CTD; 3552; -.
DR   RGD; 2890; Il1a.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   HOGENOM; HOG000113034; -.
DR   HOVERGEN; HBG002432; -.
DR   InParanoid; P16598; -.
DR   KO; K04383; -.
DR   PhylomeDB; P16598; -.
DR   PRO; PR:P16598; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0009986; C:cell surface; IDA:RGD.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IMP:RGD.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0002526; P:acute inflammatory response; IEP:RGD.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0007507; P:heart development; IEP:RGD.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0031424; P:keratinization; IDA:RGD.
DR   GO; GO:1904445; P:negative regulation of establishment of Sertoli cell barrier; IDA:RGD.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:RGD.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:RGD.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IMP:RGD.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IDA:RGD.
DR   GO; GO:1902624; P:positive regulation of neutrophil migration; IMP:RGD.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IDA:RGD.
DR   GO; GO:0010893; P:positive regulation of steroid biosynthetic process; IDA:RGD.
DR   GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IDA:RGD.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IDA:RGD.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IDA:RGD.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   GO; GO:0010332; P:response to gamma radiation; IEP:RGD.
DR   GO; GO:0009408; P:response to heat; IEP:RGD.
DR   GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR   GO; GO:0033591; P:response to L-ascorbic acid; IEP:RGD.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR   GO; GO:0010033; P:response to organic substance; IEP:RGD.
DR   GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
DR   GO; GO:0010193; P:response to ozone; IEP:RGD.
DR   GO; GO:0007283; P:spermatogenesis; IEP:RGD.
DR   GO; GO:0042060; P:wound healing; IEP:RGD.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    114
FT                                /FTId=PRO_0000015279.
FT   CHAIN       115    270       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015280.
FT   MOD_RES      90     90       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   CARBOHYD     46     46       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    139    139       N-linked (GlcNAc...). {ECO:0000255}.
SQ   SEQUENCE   270 AA;  30856 MW;  E3EB22F576F291DE CRC64;
     MAKVPDLFED LKNCYSENEE YSSAIDHLSL NQKSFYDASY GSLHENCTDK FVSLRTSETS
     KMSTFTFKES RVVVSATSNK GKILKKRRLS FNQPFTEDDL EAIAHDLEET IQPRSAPHSF
     QNNLRYKLIR IVKQEFIMND SLNQNIYVDM DRIHLKAASL NDLQLEVKFD MYAYSSGGDD
     SKYPVTLKVS NTQLFVSAQG EDKPVLLKEI PETPKLITGS ETDLIFFWEK INSKNYFTSA
     AFPELLIATK EQSQVHLARG LPSMIDFQIS
//
ID   IL1A_SHEEP              Reviewed;         268 AA.
AC   Q28579;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   11-NOV-2015, entry version 85.
DE   RecName: Full=Interleukin-1 alpha;
DE            Short=IL-1 alpha;
DE   Flags: Precursor;
GN   Name=IL1A;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1292627; DOI=10.1016/1043-4666(92)90002-9;
RA   Fiskerstrand C.E., Roy D.J., Green I., Sargan D.R.;
RT   "Cloning, expression and characterization of ovine interleukins 1
RT   alpha and beta.";
RL   Cytokine 4:418-428(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1769692;
RA   Andrews A.E., Barcham G.J., Brandon M.R., Nash A.D.;
RT   "Molecular cloning and characterization of ovine IL-1 alpha and IL-1
RT   beta.";
RL   Immunology 74:453-460(1991).
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific
CC       hydrophobic segment in the precursor sequence suggests that IL-1
CC       is released by damaged cells or is secreted by a mechanism
CC       differing from that used for other secretory proteins.
CC   -!- DOMAIN: The similarity among the IL-1 precursors suggests that the
CC       amino ends of these proteins serve some as yet undefined function.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
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DR   EMBL; X60167; CAA42732.1; -; mRNA.
DR   PIR; A61246; A61246.
DR   RefSeq; NP_001009808.1; NM_001009808.1.
DR   UniGene; Oar.433; -.
DR   ProteinModelPortal; Q28579; -.
DR   GeneID; 443404; -.
DR   KEGG; oas:443404; -.
DR   CTD; 3552; -.
DR   HOVERGEN; HBG002432; -.
DR   KO; K04383; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0046688; P:response to copper ion; ISS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Inflammatory response;
KW   Mitogen; Phosphoprotein; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    112       {ECO:0000250}.
FT                                /FTId=PRO_0000015281.
FT   CHAIN       113    268       Interleukin-1 alpha.
FT                                /FTId=PRO_0000015282.
FT   MOD_RES      87     87       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P01582}.
FT   CARBOHYD    102    102       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    141    141       N-linked (GlcNAc...). {ECO:0000255}.
FT   CONFLICT     74     74       V -> M (in Ref. 2). {ECO:0000305}.
FT   CONFLICT    153    153       M -> L (in Ref. 2). {ECO:0000305}.
FT   CONFLICT    204    204       H -> L (in Ref. 2). {ECO:0000305}.
FT   CONFLICT    264    264       L -> Q (in Ref. 2). {ECO:0000305}.
SQ   SEQUENCE   268 AA;  30925 MW;  A4E2FC6489957FC5 CRC64;
     MAKVPDLFED LKNCYSENED YSSEIDHLSL NQKSFYDASY EPLREDHMNK FMSLDTSETS
     KTSRLSFKEN VVMVTANGKI LKKRRLSLNQ FITDDDLEAI ANDTEEEIIK PRSAHYSFQS
     NVKYNFMRVI HQECILNDAL NQSIIRDMSG PYMTAATLNN LEEAVKFDMV AYVSEEDSQL
     PVTLRISKTQ LFVSAQNEDE PVLHKEMPET PKIIKDETNL LFFWEKHGSM DYFKSVAHPK
     LFIATKQEKL VHMASGPPSI TDFLILEK
//
ID   IL1B_BOVIN              Reviewed;         266 AA.
AC   P09428; A9QWQ5;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   08-JUN-2016, entry version 118.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=IL1B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3262866; DOI=10.1093/nar/16.18.9054;
RA   Leong S.R., Flaggs G.M., Lawman M., Gray P.W.;
RT   "The nucleotide sequence for the cDNA of bovine interleukin-1 beta.";
RL   Nucleic Acids Res. 16:9054-9054(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3261832; DOI=10.1016/0161-5890(88)90162-9;
RA   Maliszewski C.R., Baker P.E., Schoenborn M.A., Davis B.S., Cosman D.,
RA   Gillis S., Cerretti D.P.;
RT   "Cloning, sequence and expression of bovine interleukin 1 alpha and
RT   interleukin 1 beta complementary DNAs.";
RL   Mol. Immunol. 25:429-437(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Belted Galloway; TISSUE=Peripheral blood;
RG   U.S. Veterinary Immune Reagent Network;
RA   Hudgens T., Tompkins D., Baldwin C.L.;
RT   "U.S. veterinary immune reagent network: expressed bovine gene
RT   sequences.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
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DR   EMBL; M35589; AAA30585.1; -; mRNA.
DR   EMBL; X12498; CAA31018.1; -; mRNA.
DR   EMBL; M37211; AAA30584.1; -; mRNA.
DR   EMBL; EU276067; ABX72065.1; -; mRNA.
DR   PIR; JL0010; ICBO1B.
DR   RefSeq; NP_776518.1; NM_174093.1.
DR   UniGene; Bt.4856; -.
DR   ProteinModelPortal; P09428; -.
DR   SMR; P09428; 114-265.
DR   STRING; 9913.ENSBTAP00000001745; -.
DR   PaxDb; P09428; -.
DR   PRIDE; P09428; -.
DR   GeneID; 281251; -.
DR   KEGG; bta:281251; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; P09428; -.
DR   KO; K04519; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; NAS:AgBase.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle;
KW   Inflammatory response; Lysosome; Mitogen; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    113
FT                                /FTId=PRO_0000015283.
FT   CHAIN       114    266       Interleukin-1 beta.
FT                                /FTId=PRO_0000015284.
FT   CONFLICT     27     27       D -> G (in Ref. 3; ABX72065).
FT                                {ECO:0000305}.
FT   CONFLICT    252    252       G -> A (in Ref. 1; AAA30585/CAA31018).
FT                                {ECO:0000305}.
SQ   SEQUENCE   266 AA;  30760 MW;  9D1EF8F575070218 CRC64;
     MATVPEPINE MMAYYSDENE LLFEADDPKQ MKSCIQHLDL GSMGDGNIQL QISHQFYNKS
     FRQVVSVIVA MEKLRNSAYA HVFHDDDLRS ILSFIFEEEP VIFETSSDEF LCDAPVQSIK
     CKLQDREQKS LVLASPCVLK ALHLLSQEMN REVVFCMSFV QGEERDNKIP VALGIKDKNL
     YLSCVKKGDT PTLQLEEVDP KVYPKRNMEK RFVFYKTEIK NTVEFESVLY PNWYISTSQI
     EERPVFLGHF RGGQDITDFR METLSP
//
ID   IL1B_CANLF              Reviewed;         266 AA.
AC   Q28292; Q006K6;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   08-JUN-2016, entry version 103.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=IL1B;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Soller J.T., Murua Escobar H., Janssen M., Fork M., Bullerdiek J.,
RA   Nolte I.;
RT   "Cytokine gene single nucleotide polymorphism (SNP) screening analyses
RT   in canine malignant histiocytosis.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 28-153.
RC   STRAIN=Beagle; TISSUE=Blood;
RA   Gilmore W.H., Carter S.D., Bennett M., Barnes A., Kelly D.F.;
RT   "Expression of canine TNF, IL-1 and IL-6 mRNAs in peripheral blood
RT   monocytes and cell lines.";
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DQ923807; ABJ51908.1; -; mRNA.
DR   EMBL; Z70047; CAA93909.1; -; mRNA.
DR   UniGene; Cfa.33592; -.
DR   ProteinModelPortal; Q28292; -.
DR   SMR; Q28292; 115-266.
DR   STRING; 9615.ENSCAFP00000010762; -.
DR   PaxDb; Q28292; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; Q28292; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle;
KW   Inflammatory response; Lysosome; Mitogen; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    114       {ECO:0000250}.
FT                                /FTId=PRO_0000015285.
FT   CHAIN       115    266       Interleukin-1 beta.
FT                                /FTId=PRO_0000015286.
FT   CONFLICT     31     32       ND -> GSN (in Ref. 2; CAA93909).
FT                                {ECO:0000305}.
FT   CONFLICT    153    153       Q -> A (in Ref. 2; CAA93909).
FT                                {ECO:0000305}.
SQ   SEQUENCE   266 AA;  30259 MW;  3F7FE73949D1E3D9 CRC64;
     MAAVPELTSE MMAYSSNNEN DLFFEADGPG NDVKCCCQDL NHSSLVDEGI QLQVSHQLCN
     KSLRHFVSVI VALEKLKKPC PQVLQEDDLK SIFCYIFEEE PIICKTDADN FMSDAAMQSV
     DCKLQDISHK YLVLSNSYEL RALHLNGENV NKQVVFHMSF VHGDESNNKI PVVLGIKQKN
     LYLSCVMKDG KPTLQLEKVD PKVYPKRKME KRFVFNKIEI KNTVEFESSQ YPNWYISTSQ
     VEGMPVFLGN TRGGQDITDF TMEFSS
//
ID   IL1B_CAVPO              Reviewed;         266 AA.
AC   Q9WVG1;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   11-MAY-2016, entry version 101.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=IL1B;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=2; TISSUE=Spleen;
RX   PubMed=10394101; DOI=10.1159/000024184;
RA   Yoshimura T., Takeya M., Ogata H., Yamashiro S., Modi W.S.,
RA   Gillitzer R.;
RT   "Molecular cloning of the guinea pig GRO gene and its rapid expression
RT   in the tissues of lipopolysaccharide-injected guinea pigs.";
RL   Int. Arch. Allergy Immunol. 119:101-111(1999).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF119622; AAD38502.1; -; mRNA.
DR   RefSeq; NP_001166439.1; NM_001172968.1.
DR   RefSeq; XP_013002735.1; XM_013147281.1.
DR   ProteinModelPortal; Q9WVG1; -.
DR   SMR; Q9WVG1; 124-265.
DR   STRING; 10141.ENSCPOP00000001784; -.
DR   Ensembl; ENSCPOT00000001999; ENSCPOP00000001784; ENSCPOG00000001975.
DR   GeneID; 100135556; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; Q9WVG1; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle;
KW   Inflammatory response; Lysosome; Mitogen; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    114       {ECO:0000250}.
FT                                /FTId=PRO_0000015289.
FT   CHAIN       115    266       Interleukin-1 beta.
FT                                /FTId=PRO_0000015290.
SQ   SEQUENCE   266 AA;  30531 MW;  46558BA16B4C529A CRC64;
     MAAVPELSSE VTAYHSDENE LFFEVDGPNK MQYCFQDRDL CSLDEGIKLQ ISHQHFNKSF
     RQTVSLIVAV EKLRKKLAPC TWAFQDDDLR PLLPFIFEEE PIVCDTWDEE YESDTPVPSR
     NCTLHDIQHK RLVLSDPCEL KALHLNGDNL NRQVVFSMSF VQGERSDNKM PVALGLKGKN
     LYLSCVMKDG KPVLQLESVD GKQYPKKKME KRFVFNKITS KSTVEFESAQ FPNWYISTSQ
     AEHKPVFLGN NNGQDIIDFK LELVSS
//
ID   IL1B_FELCA              Reviewed;         267 AA.
AC   P41687;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   08-JUN-2016, entry version 94.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=IL1B;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RA   Daniel S.L., Brenner C.A., Legendre A.M., Soloman A., Rouse B.T.;
RT   "Feline cytokines TNF alpha and IL-1 beta: PCR cloning and sequencing
RT   of cDNA.";
RL   Anim. Biotechnol. 3:117-121(1992).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; M92060; AAA30814.1; -; mRNA.
DR   RefSeq; NP_001070882.1; NM_001077414.1.
DR   ProteinModelPortal; P41687; -.
DR   SMR; P41687; 116-267.
DR   STRING; 9685.ENSFCAP00000005482; -.
DR   GeneID; 768274; -.
DR   KEGG; fca:768274; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; P41687; -.
DR   KO; K04519; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle;
KW   Inflammatory response; Lysosome; Mitogen; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    115       {ECO:0000250}.
FT                                /FTId=PRO_0000015297.
FT   CHAIN       116    267       Interleukin-1 beta.
FT                                /FTId=PRO_0000015298.
SQ   SEQUENCE   267 AA;  30362 MW;  781F9971E32F6AE1 CRC64;
     MAPVPELTSE MMAYYSDEND LFFEADGPEK MKGSLQNLSH SFLGDEGIQL QISHQPDNKS
     LRHAVSVIVA MEKLKKISFA CSQPLQDEDL KSLFCCIFEE EPIICDTWDD GFVCDAAIQS
     QDYTFRDISQ KSLVLSGSYE LRALHLNGQN MNQQVVFRMS FVHGEENSKK IPVVLCIKKN
     NLYLSCVMKD GKPTLQLEML DPKVYPKKKM EKRFVFNKTE IKGNVEFESS QFPNWYISTS
     QAEEMPVFLG NTKGGQDITD FIMESAS
//
ID   IL1B_HORSE              Reviewed;         268 AA.
AC   Q28386; O18995; O77744;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   08-JUN-2016, entry version 100.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=IL1B;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
RX   PubMed=8578682; DOI=10.1016/0165-2427(95)05441-8;
RA   Kato H., Ohashi T., Nakamura N., Nishimura Y., Watari T., Goitsuka R.,
RA   Tsujimoto H., Hasegawa A.;
RT   "Molecular cloning of equine interleukin-1 alpha and -beta cDNAs.";
RL   Vet. Immunol. Immunopathol. 48:221-231(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
RX   PubMed=9622738;
RA   Howard R.D., McIlwraith C.W., Trotter G.W., Nyborg J.K.;
RT   "Cloning of equine interleukin-1 alpha and equine interleukin-1 beta
RT   and determination of their full-length cDNA sequences.";
RL   Am. J. Vet. Res. 59:704-711(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RX   PubMed=8921838; DOI=10.1016/0378-1119(96)00262-4;
RA   Kato H., Youn H.Y., Ohashi T., Watari T., Goitsuka R., Tsujimoto H.,
RA   Hasegawa A.;
RT   "Identification of an alternatively spliced transcript of equine
RT   interleukin-1 beta.";
RL   Gene 177:11-16(1996).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=Q28386-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=Q28386-2; Sequence=VSP_002648;
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; D42147; BAA07718.1; -; mRNA.
DR   EMBL; U92481; AAC39256.1; -; mRNA.
DR   EMBL; D42165; BAA22528.1; -; mRNA.
DR   PIR; JC5646; JC5646.
DR   RefSeq; NP_001075995.1; NM_001082526.1.
DR   RefSeq; NP_001304190.1; NM_001317261.1. [Q28386-1]
DR   UniGene; Eca.13475; -.
DR   ProteinModelPortal; Q28386; -.
DR   SMR; Q28386; 116-268.
DR   STRING; 9796.ENSECAP00000000159; -.
DR   PaxDb; Q28386; -.
DR   GeneID; 100034237; -.
DR   GeneID; 100052414; -.
DR   KEGG; ecb:100034237; -.
DR   KEGG; ecb:100052414; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; Q28386; -.
DR   KO; K04519; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Cytokine; Cytoplasm;
KW   Cytoplasmic vesicle; Inflammatory response; Lysosome; Mitogen;
KW   Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    115       {ECO:0000250}.
FT                                /FTId=PRO_0000015299.
FT   CHAIN       116    268       Interleukin-1 beta.
FT                                /FTId=PRO_0000015300.
FT   VAR_SEQ     101    154       Missing (in isoform Short).
FT                                {ECO:0000303|PubMed:8921838}.
FT                                /FTId=VSP_002648.
FT   CONFLICT     45     45       D -> N (in Ref. 2; AAC39256).
FT                                {ECO:0000305}.
FT   CONFLICT     55     55       H -> Q (in Ref. 2; AAC39256).
FT                                {ECO:0000305}.
FT   CONFLICT     64     65       AM -> VV (in Ref. 2; AAC39256).
FT                                {ECO:0000305}.
FT   CONFLICT     71     71       V -> M (in Ref. 2; AAC39256).
FT                                {ECO:0000305}.
FT   CONFLICT    110    111       EG -> DD (in Ref. 2; AAC39256).
FT                                {ECO:0000305}.
FT   CONFLICT    118    118       M -> V (in Ref. 2; AAC39256).
FT                                {ECO:0000305}.
FT   CONFLICT    245    245       S -> K (in Ref. 2; AAC39256).
FT                                {ECO:0000305}.
SQ   SEQUENCE   268 AA;  30268 MW;  336F27792A1542EA CRC64;
     MAAVPDTSDM MTYCSGNEND LFFEEDGPKQ MKGSFQDLDL SSMGDGGIQL QFSHHLYNKT
     FKHAMSIIVA VEKLKKIPVP CSQAFQDDDL RSLFSVIFEE EPIICDNWDE GYVCDAAMHS
     VNCRLRDIYH KSLVLSGACE LQAVHLNGEN TNQQVVFCMS FVQGEEETDK IPVALGLKEK
     NLYLSCGMKD GKPTLQLETV DPNTYPKRKM EKRFVFNKME IKGNVEFESA MYPNWYISTS
     QAEKSPVFLG NTRGGRDITD FIMEITSA
//
ID   IL1B_HUMAN              Reviewed;         269 AA.
AC   P01584; Q53X59; Q53XX2; Q7M4S7; Q7RU01; Q96HE5; Q9UCT6;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 2.
DT   06-JUL-2016, entry version 202.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   AltName: Full=Catabolin;
DE   Flags: Precursor;
GN   Name=IL1B; Synonyms=IL1F2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6083565; DOI=10.1073/pnas.81.24.7907;
RA   Auron P.E., Webb A.C., Rosenwasser L.J., Mucci S.F., Rich A.,
RA   Wolff S.M., Dinarello C.A.;
RT   "Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:7907-7911(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2989698; DOI=10.1038/315641a0;
RA   March C.J., Mosley B., Larsen A., Cerretti D.P., Braedt G., Price V.,
RA   Gillis S., Henney C.S., Kronheim S.R., Grabstein K., Conlon P.J.,
RA   Hopp T.P., Cosman D.;
RT   "Cloning, sequence and expression of two distinct human interleukin-1
RT   complementary DNAs.";
RL   Nature 315:641-647(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Leukocyte;
RX   PubMed=3490654; DOI=10.1093/nar/14.20.7897;
RA   Clark B.D., Collins K.L., Gandy M.S., Webb A.C., Auron P.E.;
RT   "Genomic sequence for human prointerleukin 1 beta: possible evolution
RT   from a reverse transcribed prointerleukin 1 alpha gene.";
RL   Nucleic Acids Res. 14:7897-7914(1986).
RN   [4]
RP   ERRATUM.
RA   Clark B.D., Collins K.L., Gandy M.S., Webb A.C., Auron P.E.;
RL   Nucleic Acids Res. 15:868-868(1987).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Histiocytic lymphoma;
RX   PubMed=3493774;
RA   Nishida T., Nishino N., Takano M., Kawai K., Bando K., Masui Y.,
RA   Nakai S., Hirai Y.;
RT   "cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell
RT   line.";
RL   Biochem. Biophys. Res. Commun. 143:345-352(1987).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2954882; DOI=10.1016/0378-1119(87)90398-2;
RA   Bensi G., Raugei G., Palla E., Carinci V., Buonamassa D.T., Melli M.;
RT   "Human interleukin-1 beta gene.";
RL   Gene 52:95-101(1987).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Monocyte;
RX   PubMed=2635664;
RA   Kotenko S.V., Bulenkov M.T., Veiko V.P., Epishin S.M., Lomakin I.B.,
RA   Emel'Yanov A.V., Kozlov A.P., Konusova V.G., Kotov A.Y.,
RA   Kurbatova T.V., Reshetnikov V.L., Simbirtsev A.S., Ketlinskii S.A.,
RA   Vinetskii Y.P.;
RT   "Cloning of the cDNA coding for human prointerleukin-1 alpha and
RT   prointerleukin-1 beta.";
RL   Dokl. Akad. Nauk SSSR 309:1005-1008(1989).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [11]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   SeattleSNPs variation discovery resource;
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [12]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [13]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [14]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [15]
RP   PROTEIN SEQUENCE OF 114-135.
RC   TISSUE=Skin;
RX   PubMed=1919436; DOI=10.1084/jem.174.4.821;
RA   Mizutani H., Schechter N., Lazarus G., Black R.A., Kupper T.S.;
RT   "Rapid and specific conversion of precursor interleukin 1 beta (IL-1
RT   beta) to an active IL-1 species by human mast cell chymase.";
RL   J. Exp. Med. 174:821-825(1991).
RN   [16]
RP   PROTEIN SEQUENCE OF 117-155, VARIANT ASN-141, FUNCTION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=3920526; DOI=10.1038/314266a0;
RA   Van Damme J., De Ley M., Opdenakker G., Billiau A., De Somer P.,
RA   Van Beeumen J.;
RT   "Homogeneous interferon-inducing 22K factor is related to endogenous
RT   pyrogen and interleukin-1.";
RL   Nature 314:266-268(1985).
RN   [17]
RP   PROTEIN SEQUENCE OF 117-128.
RX   PubMed=3281727;
RA   Zsebo K.M., Wypych J., Yuschenkoff V.N., Lu H., Hunt P., Dukes P.P.,
RA   Langley K.E.;
RT   "Effects of hematopoietin-1 and interleukin 1 activities on early
RT   hematopoietic cells of the bone marrow.";
RL   Blood 71:962-968(1988).
RN   [18]
RP   RECEPTOR-BINDING.
RX   PubMed=1837236; DOI=10.1016/0167-4838(91)90437-5;
RA   Nanduri V.B., Hulmes J.D., Pan Y.C., Kilian P.L., Stern A.S.;
RT   "The role of arginine residues in interleukin 1 receptor binding.";
RL   Biochim. Biophys. Acta 1118:25-35(1991).
RN   [19]
RP   SUBCELLULAR LOCATION.
RX   PubMed=11728343; DOI=10.1016/S1074-7613(01)00229-1;
RA   MacKenzie A., Wilson H.L., Kiss-Toth E., Dower S.K., North R.A.,
RA   Surprenant A.;
RT   "Rapid secretion of interleukin-1beta by microvesicle shedding.";
RL   Immunity 15:825-835(2001).
RN   [20]
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION BY LPS, AND
RP   PROCESSING BY THE INFLAMMASOME.
RX   PubMed=15192144; DOI=10.1073/pnas.0308558101;
RA   Andrei C., Margiocco P., Poggi A., Lotti L.V., Torrisi M.R.,
RA   Rubartelli A.;
RT   "Phospholipases C and A2 control lysosome-mediated IL-1 beta
RT   secretion: Implications for inflammatory processes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9745-9750(2004).
RN   [21]
RP   INTERACTION WITH MEFV.
RX   PubMed=17431422; DOI=10.1038/sj.cdd.4402142;
RA   Papin S., Cuenin S., Agostini L., Martinon F., Werner S., Beer H.D.,
RA   Grutter C., Grutter M., Tschopp J.;
RT   "The SPRY domain of Pyrin, mutated in familial Mediterranean fever
RT   patients, interacts with inflammasome components and inhibits proIL-
RT   1beta processing.";
RL   Cell Death Differ. 14:1457-1466(2007).
RN   [22]
RP   REVIEW ON SECRETION, AND SUBCELLULAR LOCATION.
RX   PubMed=24201029; DOI=10.1016/j.smim.2013.10.007;
RA   Piccioli P., Rubartelli A.;
RT   "The secretion of IL-1beta and options for release.";
RL   Semin. Immunol. 25:425-429(2013).
RN   [23]
RP   MUTAGENESIS OF ASP-27 AND ASP-116.
RX   PubMed=24952504; DOI=10.1038/ni.2919;
RA   Baroja-Mazo A., Martin-Sanchez F., Gomez A.I., Martinez C.M.,
RA   Amores-Iniesta J., Compan V., Barbera-Cremades M., Yaguee J.,
RA   Ruiz-Ortiz E., Anton J., Bujan S., Couillin I., Brough D.,
RA   Arostegui J.I., Pelegrin P.;
RT   "The NLRP3 inflammasome is released as a particulate danger signal
RT   that amplifies the inflammatory response.";
RL   Nat. Immunol. 15:738-748(2014).
RN   [24]
RP   X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
RX   PubMed=3259176;
RA   Priestle J.P., Schar H.-P., Grutter M.G.;
RT   "Crystal structure of the cytokine interleukin-1 beta.";
RL   EMBO J. 7:339-343(1988).
RN   [25]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RX   PubMed=2585509; DOI=10.1016/0022-2836(89)90606-2;
RA   Finzel B.C., Clancy L.L., Holland D.R., Muchmore S.W.,
RA   Watenpaugh K.D., Einspahr H.M.;
RT   "Crystal structure of recombinant human interleukin-1 beta at 2.0-A
RT   resolution.";
RL   J. Mol. Biol. 209:779-791(1989).
RN   [26]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RX   PubMed=2602367; DOI=10.1073/pnas.86.24.9667;
RA   Priestle J.P., Schar H.-P., Gruetter M.G.;
RT   "Crystallographic refinement of interleukin 1 beta at 2.0-A
RT   resolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:9667-9671(1989).
RN   [27]
RP   STRUCTURE BY NMR.
RX   PubMed=2372550; DOI=10.1021/bi00471a023;
RA   Driscoll P.C., Gronenborn A.M., Wingfield P.T., Clore G.M.;
RT   "Determination of the secondary structure and molecular topology of
RT   interleukin-1 beta by use of two- and three-dimensional heteronuclear
RT   15N-1H NMR spectroscopy.";
RL   Biochemistry 29:4668-4682(1990).
RN   [28]
RP   STRUCTURE BY NMR.
RX   PubMed=2001363; DOI=10.1021/bi00223a005;
RA   Clore G.M., Wingfield P.T., Gronenborn A.M.;
RT   "High-resolution three-dimensional structure of interleukin 1 beta in
RT   solution by three- and four-dimensional nuclear magnetic resonance
RT   spectroscopy.";
RL   Biochemistry 30:2315-2323(1991).
RN   [29]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF COMPLEX WITH RECEPTOR.
RX   PubMed=9062193; DOI=10.1038/386190a0;
RA   Vigers G.P.A., Anderson L.J., Caffes P., Brandhuber B.J.;
RT   "Crystal structure of the type-I interleukin-1 receptor complexed with
RT   interleukin-1beta.";
RL   Nature 386:190-194(1997).
RN   [30]
RP   X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 117-269 IN COMPLEX WITH IL1R2
RP   AND IL1RAP.
RX   PubMed=20802483; DOI=10.1038/ni.1925;
RA   Wang D., Zhang S., Li L., Liu X., Mei K., Wang X.;
RT   "Structural insights into the assembly and activation of IL-1beta with
RT   its receptors.";
RL   Nat. Immunol. 11:905-911(2010).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. Promotes Th17
CC       differentiation of T-cells. {ECO:0000269|PubMed:3920526}.
CC   -!- SUBUNIT: Monomer. In its precursor form, weakly interacts with
CC       full-length MEFV; the mature cytokine does not interact at all
CC       (PubMed:17431422). {ECO:0000269|PubMed:17431422,
CC       ECO:0000269|PubMed:20802483}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000269|PubMed:15192144}. Lysosome
CC       {ECO:0000269|PubMed:15192144}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000269|PubMed:24201029}. Secreted
CC       {ECO:0000269|PubMed:11728343, ECO:0000269|PubMed:15192144}.
CC       Note=The precursor is cytosolic. In response to inflammasome-
CC       activating signals, such as ATP for NLRP3 inflammasome or
CC       bacterial flagellin for NLRC4 inflammasome, cleaved and secreted.
CC       IL1B lacks any known signal sequence and the pathway(s) of its
CC       secretion is(are) not yet fully understood (PubMed:24201029). On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B (PubMed:15192144). 2. Secretory autophagy: IL1B-
CC       containing autophagosomes may fuse with endosomes or
CC       multivesicular bodies (MVBs) and then merge with the plasma
CC       membrane releasing soluble IL1B or IL1B-containing exosomes
CC       (PubMed:24201029). However, autophagy impacts IL1B production at
CC       several levels and its role in secretion is still controversial.
CC       3. Secretion via exosomes: ATP-activation of P2RX7 leads to the
CC       formation of MVBs containing exosomes with entrapped IL1B, CASP1
CC       and other inflammasome components. These MVBs undergo exocytosis
CC       with the release of exosomes. The release of soluble IL1B occurs
CC       after the lysis of exosome membranes (By similarity). 4. Secretion
CC       by microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis (PubMed:11728343). 5. Release by translocation
CC       through permeabilized plasma membrane. This may occur in cells
CC       undergoing pyroptosis due to sustained activation of the
CC       inflammasome (By similarity). These mechanisms may not be not
CC       mutually exclusive. {ECO:0000250|UniProtKB:P10749,
CC       ECO:0000269|PubMed:11728343, ECO:0000269|PubMed:15192144,
CC       ECO:0000305|PubMed:24201029}.
CC   -!- TISSUE SPECIFICITY: Expressed in activated monocytes/macrophages
CC       (at protein level). {ECO:0000269|PubMed:15192144}.
CC   -!- INDUCTION: By LPS. {ECO:0000269|PubMed:15192144}.
CC   -!- PTM: Activation of the IL1B precursor involves a CASP1-catalyzed
CC       proteolytic cleavage. Processing and secretion are temporarily
CC       associated. {ECO:0000269|PubMed:15192144}.
CC   -!- MISCELLANEOUS: The IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000269|PubMed:15192144}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/IL1BID40950ch2q13.html";
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="https://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1b/";
CC   -!- WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and
CC       polymorphism database;
CC       URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1B";
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DR   EMBL; K02770; AAA36106.1; -; mRNA.
DR   EMBL; M54933; AAA59136.1; ALT_SEQ; mRNA.
DR   EMBL; X02532; CAA26372.1; -; mRNA.
DR   EMBL; X04500; CAA28185.1; -; Genomic_DNA.
DR   EMBL; M15330; AAA59135.1; -; mRNA.
DR   EMBL; M15840; AAA74137.1; -; Genomic_DNA.
DR   EMBL; X56087; CAA39567.1; -; mRNA.
DR   EMBL; BN000002; CAD29872.1; -; Genomic_DNA.
DR   EMBL; BT007213; AAP35877.1; -; mRNA.
DR   EMBL; CR407679; CAG28607.1; -; mRNA.
DR   EMBL; AY137079; AAM88883.1; -; Genomic_DNA.
DR   EMBL; AC079753; AAX88888.1; -; Genomic_DNA.
DR   EMBL; CH471217; EAW73605.1; -; Genomic_DNA.
DR   EMBL; BC008678; AAH08678.1; -; mRNA.
DR   CCDS; CCDS2102.1; -.
DR   PIR; A21851; A21851.
DR   PIR; A25542; ICHU1B.
DR   RefSeq; NP_000567.1; NM_000576.2.
DR   UniGene; Hs.126256; -.
DR   PDB; 1HIB; X-ray; 2.40 A; A=117-269.
DR   PDB; 1I1B; X-ray; 2.00 A; A=117-269.
DR   PDB; 1IOB; X-ray; 2.00 A; A=117-269.
DR   PDB; 1ITB; X-ray; 2.50 A; A=117-269.
DR   PDB; 1L2H; X-ray; 1.54 A; A=117-269.
DR   PDB; 1S0L; X-ray; 2.34 A; A=117-269.
DR   PDB; 1T4Q; X-ray; 2.10 A; A=117-269.
DR   PDB; 1TOO; X-ray; 2.10 A; A=117-269.
DR   PDB; 1TP0; X-ray; 2.20 A; A=117-269.
DR   PDB; 1TWE; X-ray; 2.10 A; A=117-269.
DR   PDB; 1TWM; X-ray; 2.26 A; A=117-269.
DR   PDB; 21BI; X-ray; 2.00 A; A=117-269.
DR   PDB; 2I1B; X-ray; 2.00 A; A=117-269.
DR   PDB; 2KH2; NMR; -; A=117-269.
DR   PDB; 2NVH; X-ray; 1.53 A; A=117-269.
DR   PDB; 31BI; X-ray; 2.00 A; A=117-269.
DR   PDB; 3LTQ; X-ray; 2.10 A; A=117-269.
DR   PDB; 3O4O; X-ray; 3.30 A; A=117-269.
DR   PDB; 3POK; X-ray; 1.70 A; A=117-269.
DR   PDB; 41BI; X-ray; 2.90 A; A=117-269.
DR   PDB; 4DEP; X-ray; 3.10 A; A/D=117-269.
DR   PDB; 4G6J; X-ray; 2.03 A; A=117-269.
DR   PDB; 4G6M; X-ray; 1.81 A; A=118-267.
DR   PDB; 4GAF; X-ray; 2.15 A; A=117-269.
DR   PDB; 4GAI; X-ray; 1.49 A; A/B=117-269.
DR   PDB; 4I1B; X-ray; 2.00 A; A=117-269.
DR   PDB; 5BVP; X-ray; 2.20 A; I=117-269.
DR   PDB; 5I1B; X-ray; 2.10 A; A=117-269.
DR   PDB; 6I1B; NMR; -; A=117-269.
DR   PDB; 7I1B; NMR; -; A=117-269.
DR   PDB; 9ILB; X-ray; 2.28 A; A=117-269.
DR   PDBsum; 1HIB; -.
DR   PDBsum; 1I1B; -.
DR   PDBsum; 1IOB; -.
DR   PDBsum; 1ITB; -.
DR   PDBsum; 1L2H; -.
DR   PDBsum; 1S0L; -.
DR   PDBsum; 1T4Q; -.
DR   PDBsum; 1TOO; -.
DR   PDBsum; 1TP0; -.
DR   PDBsum; 1TWE; -.
DR   PDBsum; 1TWM; -.
DR   PDBsum; 21BI; -.
DR   PDBsum; 2I1B; -.
DR   PDBsum; 2KH2; -.
DR   PDBsum; 2NVH; -.
DR   PDBsum; 31BI; -.
DR   PDBsum; 3LTQ; -.
DR   PDBsum; 3O4O; -.
DR   PDBsum; 3POK; -.
DR   PDBsum; 41BI; -.
DR   PDBsum; 4DEP; -.
DR   PDBsum; 4G6J; -.
DR   PDBsum; 4G6M; -.
DR   PDBsum; 4GAF; -.
DR   PDBsum; 4GAI; -.
DR   PDBsum; 4I1B; -.
DR   PDBsum; 5BVP; -.
DR   PDBsum; 5I1B; -.
DR   PDBsum; 6I1B; -.
DR   PDBsum; 7I1B; -.
DR   PDBsum; 9ILB; -.
DR   ProteinModelPortal; P01584; -.
DR   SMR; P01584; 117-268.
DR   BioGrid; 109769; 15.
DR   DIP; DIP-474N; -.
DR   IntAct; P01584; 6.
DR   MINT; MINT-189806; -.
DR   STRING; 9606.ENSP00000263341; -.
DR   BindingDB; P01584; -.
DR   ChEMBL; CHEMBL1909490; -.
DR   DrugBank; DB06168; Canakinumab.
DR   DrugBank; DB05260; Gallium nitrate.
DR   DrugBank; DB01017; Minocycline.
DR   DrugBank; DB06372; Rilonacept.
DR   GuidetoPHARMACOLOGY; 2623; -.
DR   iPTMnet; P01584; -.
DR   BioMuta; IL1B; -.
DR   DMDM; 62906858; -.
DR   EPD; P01584; -.
DR   MaxQB; P01584; -.
DR   PaxDb; P01584; -.
DR   PeptideAtlas; P01584; -.
DR   PRIDE; P01584; -.
DR   DNASU; 3553; -.
DR   Ensembl; ENST00000263341; ENSP00000263341; ENSG00000125538.
DR   GeneID; 3553; -.
DR   KEGG; hsa:3553; -.
DR   UCSC; uc002tii.2; human.
DR   CTD; 3553; -.
DR   GeneCards; IL1B; -.
DR   HGNC; HGNC:5992; IL1B.
DR   MalaCards; IL1B; -.
DR   MIM; 147720; gene.
DR   neXtProt; NX_P01584; -.
DR   PharmGKB; PA29808; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; P01584; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   PhylomeDB; P01584; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-HSA-446652; Interleukin-1 signaling.
DR   Reactome; R-HSA-448706; Interleukin-1 processing.
DR   Reactome; R-HSA-5660668; CLEC7A/inflammasome pathway.
DR   SignaLink; P01584; -.
DR   SIGNOR; P01584; -.
DR   ChiTaRS; IL1B; human.
DR   EvolutionaryTrace; P01584; -.
DR   GeneWiki; IL1B; -.
DR   GenomeRNAi; 3553; -.
DR   PMAP-CutDB; P01584; -.
DR   PRO; PR:P01584; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; P01584; -.
DR   CleanEx; HS_IL1B; -.
DR   ExpressionAtlas; P01584; baseline and differential.
DR   Genevisible; P01584; HS.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IDA:BHF-UCL.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; NAS:UniProtKB.
DR   GO; GO:0019904; F:protein domain specific binding; IPI:UniProtKB.
DR   GO; GO:0000187; P:activation of MAPK activity; IDA:BHF-UCL.
DR   GO; GO:0007568; P:aging; IEA:Ensembl.
DR   GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0071236; P:cellular response to antibiotic; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IDA:MGI.
DR   GO; GO:0071398; P:cellular response to fatty acid; IEA:Ensembl.
DR   GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.
DR   GO; GO:0071414; P:cellular response to methotrexate; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IDA:UniProtKB.
DR   GO; GO:0071310; P:cellular response to organic substance; IDA:MGI.
DR   GO; GO:0002439; P:chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:BHF-UCL.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0007566; P:embryo implantation; TAS:BHF-UCL.
DR   GO; GO:0008210; P:estrogen metabolic process; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0009100; P:glycoprotein metabolic process; IEA:Ensembl.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IDA:UniProtKB.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IDA:UniProtKB.
DR   GO; GO:0000165; P:MAPK cascade; IMP:UniProtKB.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IDA:UniProtKB.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; ISS:BHF-UCL.
DR   GO; GO:2000173; P:negative regulation of branching morphogenesis of a nerve; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IDA:BHF-UCL.
DR   GO; GO:0010829; P:negative regulation of glucose transport; ISS:BHF-UCL.
DR   GO; GO:0014050; P:negative regulation of glutamate secretion; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:BHF-UCL.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IDA:BHF-UCL.
DR   GO; GO:0045833; P:negative regulation of lipid metabolic process; ISS:BHF-UCL.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; ISS:BHF-UCL.
DR   GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IEA:Ensembl.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0030728; P:ovulation; IEA:Ensembl.
DR   GO; GO:0019742; P:pentacyclic triterpenoid metabolic process; IEA:Ensembl.
DR   GO; GO:0030638; P:polyketide metabolic process; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISS:BHF-UCL.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0048711; P:positive regulation of astrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IDA:BHF-UCL.
DR   GO; GO:0060355; P:positive regulation of cell adhesion molecule production; NAS:BHF-UCL.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; ISS:BHF-UCL.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IDA:BHF-UCL.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IDA:UniProtKB.
DR   GO; GO:0035066; P:positive regulation of histone acetylation; NAS:BHF-UCL.
DR   GO; GO:0033129; P:positive regulation of histone phosphorylation; NAS:BHF-UCL.
DR   GO; GO:0033092; P:positive regulation of immature T cell proliferation in thymus; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:BHF-UCL.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IMP:BHF-UCL.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; TAS:BHF-UCL.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IDA:UniProtKB.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0043507; P:positive regulation of JUN kinase activity; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; ISS:BHF-UCL.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IDA:BHF-UCL.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IMP:BHF-UCL.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IDA:UniProtKB.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IDA:BHF-UCL.
DR   GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IDA:BHF-UCL.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:BHF-UCL.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IDA:BHF-UCL.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IMP:AgBase.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; ISS:BHF-UCL.
DR   GO; GO:0046827; P:positive regulation of protein export from nucleus; NAS:BHF-UCL.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:BHF-UCL.
DR   GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
DR   GO; GO:0002711; P:positive regulation of T cell mediated immunity; IC:BHF-UCL.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:BHF-UCL.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IDA:BHF-UCL.
DR   GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IC:BHF-UCL.
DR   GO; GO:0043491; P:protein kinase B signaling; IMP:UniProtKB.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IDA:UniProtKB.
DR   GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IDA:BHF-UCL.
DR   GO; GO:0050796; P:regulation of insulin secretion; IDA:BHF-UCL.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IDA:UniProtKB.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0071548; P:response to dexamethasone; IEA:Ensembl.
DR   GO; GO:0036270; P:response to diuretic; IEA:Ensembl.
DR   GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR   GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR   GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR   GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0033591; P:response to L-ascorbic acid; IEA:Ensembl.
DR   GO; GO:0043278; P:response to morphine; IEA:Ensembl.
DR   GO; GO:0010193; P:response to ozone; IEA:Ensembl.
DR   GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR   GO; GO:0036273; P:response to statin; IEA:Ensembl.
DR   GO; GO:0035634; P:response to stilbenoid; IEA:Ensembl.
DR   GO; GO:0033280; P:response to vitamin D; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IDA:BHF-UCL.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   GO; GO:0014805; P:smooth muscle adaptation; NAS:BHF-UCL.
DR   GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR   GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytokine; Cytoplasm;
KW   Cytoplasmic vesicle; Direct protein sequencing; Inflammatory response;
KW   Lysosome; Mitogen; Polymorphism; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    116       Removed in mature form; by CASP1.
FT                                {ECO:0000269|PubMed:3281727,
FT                                ECO:0000269|PubMed:3920526}.
FT                                /FTId=PRO_0000015301.
FT   CHAIN       117    269       Interleukin-1 beta.
FT                                {ECO:0000269|PubMed:2001363}.
FT                                /FTId=PRO_0000015302.
FT   SITE        120    120       Involved in receptor binding.
FT   VARIANT     141    141       E -> N (requires 2 nucleotide
FT                                substitutions; dbSNP:rs144640380).
FT                                {ECO:0000269|PubMed:3920526}.
FT                                /FTId=VAR_073951.
FT   MUTAGEN      27     27       D->A: Loss of activation by CASP1; when
FT                                associated with A-116.
FT                                {ECO:0000269|PubMed:24952504}.
FT   MUTAGEN     116    116       D->A: Loss of activation by CASP1; when
FT                                associated with A-27.
FT                                {ECO:0000269|PubMed:24952504}.
FT   CONFLICT      6      6       E -> K (in Ref. 1; AAA36106/AAA59136 and
FT                                10; CAG28607). {ECO:0000305}.
FT   CONFLICT    124    124       C -> A (in Ref. 16; AA sequence).
FT                                {ECO:0000305}.
FT   CONFLICT    155    155       Q -> D (in Ref. 16; AA sequence).
FT                                {ECO:0000305}.
FT   STRAND      121    128       {ECO:0000244|PDB:4GAI}.
FT   STRAND      133    137       {ECO:0000244|PDB:4GAI}.
FT   STRAND      138    140       {ECO:0000244|PDB:21BI}.
FT   STRAND      141    145       {ECO:0000244|PDB:4GAI}.
FT   HELIX       149    154       {ECO:0000244|PDB:4GAI}.
FT   STRAND      158    162       {ECO:0000244|PDB:4GAI}.
FT   STRAND      172    178       {ECO:0000244|PDB:4GAI}.
FT   TURN        179    181       {ECO:0000244|PDB:4GAI}.
FT   STRAND      183    190       {ECO:0000244|PDB:4GAI}.
FT   STRAND      193    200       {ECO:0000244|PDB:4GAI}.
FT   TURN        203    205       {ECO:0000244|PDB:4GAI}.
FT   HELIX       213    215       {ECO:0000244|PDB:4GAI}.
FT   STRAND      217    222       {ECO:0000244|PDB:4GAI}.
FT   STRAND      225    233       {ECO:0000244|PDB:4GAI}.
FT   STRAND      237    240       {ECO:0000244|PDB:4GAI}.
FT   STRAND      242    247       {ECO:0000244|PDB:4G6M}.
FT   STRAND      249    252       {ECO:0000244|PDB:4GAI}.
FT   TURN        254    257       {ECO:0000244|PDB:4GAI}.
FT   STRAND      262    266       {ECO:0000244|PDB:4GAI}.
SQ   SEQUENCE   269 AA;  30748 MW;  9BF73C3673C6FD66 CRC64;
     MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG
     FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR
     SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE
     KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST
     SQAENMPVFL GGTKGGQDIT DFTMQFVSS
//
ID   IL1B_MACMU              Reviewed;         269 AA.
AC   P48090;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   08-JUN-2016, entry version 92.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=IL1B;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   PubMed=7561102;
RA   Villinger F.J., Brar S.S., Mayne A.E., Chikkala N., Ansari A.A.;
RT   "Comparative sequence analysis of cytokine genes from human and
RT   nonhuman primates.";
RL   J. Immunol. 155:3946-3954(1995).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; U19845; AAA86709.1; -; mRNA.
DR   RefSeq; NP_001036221.1; NM_001042756.1.
DR   UniGene; Mmu.648; -.
DR   ProteinModelPortal; P48090; -.
DR   SMR; P48090; 117-269.
DR   STRING; 9544.ENSMMUP00000026007; -.
DR   GeneID; 704701; -.
DR   KEGG; mcc:704701; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; P48090; -.
DR   KO; K04519; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle;
KW   Inflammatory response; Lysosome; Mitogen; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    116       {ECO:0000250}.
FT                                /FTId=PRO_0000015307.
FT   CHAIN       117    269       Interleukin-1 beta.
FT                                /FTId=PRO_0000015308.
SQ   SEQUENCE   269 AA;  30481 MW;  A7CD59EBAC120EC7 CRC64;
     MAEVPELASE MMAYYSGNED DLFFDVDGPK QMKCSFQDLD LCPLGGGIQL QISHEHYNEG
     FRQAVSVVVA MEKLRKMLVP CPQIFQDNDL STLIPFIFEE EPVFLDTRNN DACVHDAPVR
     SLHCTLRDAQ LKSLVMSGPY ELKALHLQGQ DLEQQVVFSM SFVQGEESND KIPVALGLKA
     KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST
     SQAENMPVFL GGTRGGQDIT DFTMQFVSS
//
ID   IL1B_MOUSE              Reviewed;         269 AA.
AC   P10749; Q2M4J6;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   06-JUL-2016, entry version 162.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=Il1b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3491144;
RA   Gray P.W., Glaister D., Chen E., Goeddel D.V., Pennica D.;
RT   "Two interleukin 1 genes in the mouse: cloning and expression of the
RT   cDNA for murine interleukin 1 beta.";
RL   J. Immunol. 137:3644-3648(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3492706; DOI=10.1093/nar/14.24.9955;
RA   Telford J.L., Macchia G., Massone A., Carinci V., Palla E., Melli M.;
RT   "The murine interleukin 1 beta gene: structure and evolution.";
RL   Nucleic Acids Res. 14:9955-9963(1986).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CAST/EiJ; TISSUE=Spleen;
RA   Farber C.R., Corva P.M., Medrano J.F.;
RT   "Characterization of quantitative trait loci influencing growth and
RT   adiposity using congenic mouse strains.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 118-139.
RX   PubMed=2967326;
RA   Huang J.J., Newton R.C., Rutledge S.J., Horuk R., Matthew J.B.,
RA   Covington M., Lin Y.;
RT   "Characterization of murine IL-1 beta. Isolation, expression, and
RT   purification.";
RL   J. Immunol. 140:3838-3843(1988).
RN   [7]
RP   TISSUE SPECIFICITY, INDUCTION BY LPS, AND MISCELLANEOUS.
RX   PubMed=16407890; DOI=10.1038/nature04515;
RA   Mariathasan S., Weiss D.S., Newton K., McBride J., O'Rourke K.,
RA   Roose-Girma M., Lee W.P., Weinrauch Y., Monack D.M., Dixit V.M.;
RT   "Cryopyrin activates the inflammasome in response to toxins and ATP.";
RL   Nature 440:228-232(2006).
RN   [8]
RP   SUBCELLULAR LOCATION, INDUCTION BY LPS, AND MISCELLANEOUS.
RX   PubMed=17284521; DOI=10.1242/jcs.03377;
RA   Brough D., Rothwell N.J.;
RT   "Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic
RT   and precedes cell death.";
RL   J. Cell Sci. 120:772-781(2007).
RN   [9]
RP   SUBCELLULAR LOCATION, INDUCTION BY LPS, AND MISCELLANEOUS.
RX   PubMed=17641058; DOI=10.4049/jimmunol.179.3.1913;
RA   Qu Y., Franchi L., Nunez G., Dubyak G.R.;
RT   "Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is
RT   dependent on inflammasome activation and correlated with exosome
RT   release in murine macrophages.";
RL   J. Immunol. 179:1913-1925(2007).
RN   [10]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RX   PubMed=1807351; DOI=10.1016/1047-8477(91)90021-N;
RA   van Oostrum J., Priestle J.P., Gruetter M.G., Schmitz A.;
RT   "The structure of murine interleukin-1 beta at 2.8-A resolution.";
RL   J. Struct. Biol. 107:189-195(1991).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000305}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000269|PubMed:17284521}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000269|PubMed:17641058}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000269|PubMed:17284521, ECO:0000269|PubMed:17641058}.
CC       Note=The precursor is cytosolic. In response to inflammasome-
CC       activating signals, such as ATP for NLRP3 inflammasome or
CC       bacterial flagellin for NLRC4 inflammasome, cleaved and secreted.
CC       IL1B lacks any known signal sequence and the pathway(s) of its
CC       secretion is(are) not yet fully understood. On the basis of
CC       experimental results, several unconventional secretion mechanisms
CC       have been proposed. 1. Secretion via secretory lysosomes: a
CC       fraction of CASP1 and IL1B precursor may be incorporated, by a yet
CC       undefined mechanism, into secretory lysosomes that undergo Ca(2+)-
CC       dependent exocytosis with release of mature IL1B (By similarity).
CC       2. Secretory autophagy: IL1B-containing autophagosomes may fuse
CC       with endosomes or multivesicular bodies (MVBs) and then merge with
CC       the plasma membrane releasing soluble IL1B or IL1B-containing
CC       exosomes (By similarity). However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes
CC       (PubMed:17641058). 4. Secretion by microvesicle shedding:
CC       activation of the ATP receptor P2RX7 may induce an immediate
CC       shedding of membrane-derived microvesicles containing IL1B and
CC       possibly inflammasome components. The cytokine is then released in
CC       the extracellular compartment after microvesicle lysis (By
CC       similarity). 5. Release by translocation through permeabilized
CC       plasma membrane. This may occur in cells undergoing pyroptosis due
CC       to sustained activation of the inflammasome (PubMed:17284521).
CC       These mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000269|PubMed:17284521,
CC       ECO:0000269|PubMed:17641058}.
CC   -!- TISSUE SPECIFICITY: Expressed in activated macrophages (at protein
CC       level). {ECO:0000269|PubMed:16407890, ECO:0000269|PubMed:17284521,
CC       ECO:0000269|PubMed:17641058}.
CC   -!- INDUCTION: By LPS. {ECO:0000269|PubMed:16407890,
CC       ECO:0000269|PubMed:17284521, ECO:0000269|PubMed:17641058}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000269|PubMed:17284521,
CC       ECO:0000269|PubMed:17641058}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; M15131; AAA39276.1; -; mRNA.
DR   EMBL; X04964; CAA28637.1; -; Genomic_DNA.
DR   EMBL; AY902319; AAX90604.1; -; Genomic_DNA.
DR   EMBL; CH466519; EDL28238.1; -; Genomic_DNA.
DR   EMBL; BC011437; AAH11437.1; -; mRNA.
DR   CCDS; CCDS16726.1; -.
DR   PIR; I55969; I55969.
DR   RefSeq; NP_032387.1; NM_008361.4.
DR   UniGene; Mm.222830; -.
DR   PDB; 2MIB; X-ray; 2.84 A; A=118-269.
DR   PDB; 8I1B; X-ray; 2.40 A; A=118-269.
DR   PDBsum; 2MIB; -.
DR   PDBsum; 8I1B; -.
DR   ProteinModelPortal; P10749; -.
DR   SMR; P10749; 122-267.
DR   BioGrid; 200624; 6.
DR   IntAct; P10749; 1.
DR   STRING; 10090.ENSMUSP00000028881; -.
DR   iPTMnet; P10749; -.
DR   PaxDb; P10749; -.
DR   PRIDE; P10749; -.
DR   TopDownProteomics; P10749; -.
DR   Ensembl; ENSMUST00000028881; ENSMUSP00000028881; ENSMUSG00000027398.
DR   GeneID; 16176; -.
DR   KEGG; mmu:16176; -.
DR   UCSC; uc008mht.1; mouse.
DR   CTD; 3553; -.
DR   MGI; MGI:96543; Il1b.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; P10749; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   PhylomeDB; P10749; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-MMU-446652; Interleukin-1 signaling.
DR   Reactome; R-MMU-448706; Interleukin-1 processing.
DR   Reactome; R-MMU-5660668; CLEC7A/inflammasome pathway.
DR   EvolutionaryTrace; P10749; -.
DR   PMAP-CutDB; P10749; -.
DR   PRO; PR:P10749; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; P10749; -.
DR   CleanEx; MM_IL1B; -.
DR   Genevisible; P10749; MM.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; ISO:MGI.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0030141; C:secretory granule; IDA:MGI.
DR   GO; GO:0031982; C:vesicle; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
DR   GO; GO:0000187; P:activation of MAPK activity; ISO:MGI.
DR   GO; GO:0007568; P:aging; IEA:Ensembl.
DR   GO; GO:0071236; P:cellular response to antibiotic; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; ISO:MGI.
DR   GO; GO:0071398; P:cellular response to fatty acid; IEA:Ensembl.
DR   GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071414; P:cellular response to methotrexate; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; ISO:MGI.
DR   GO; GO:0071310; P:cellular response to organic substance; ISO:MGI.
DR   GO; GO:0002439; P:chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:MGI.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IGI:MGI.
DR   GO; GO:0008210; P:estrogen metabolic process; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IMP:MGI.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0009100; P:glycoprotein metabolic process; IEA:Ensembl.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; ISO:MGI.
DR   GO; GO:0006954; P:inflammatory response; ISO:MGI.
DR   GO; GO:0032611; P:interleukin-1 beta production; IGI:MGI.
DR   GO; GO:0050900; P:leukocyte migration; IDA:MGI.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISO:MGI.
DR   GO; GO:0000165; P:MAPK cascade; ISO:MGI.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; ISO:MGI.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IDA:BHF-UCL.
DR   GO; GO:2000173; P:negative regulation of branching morphogenesis of a nerve; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; ISO:MGI.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISO:MGI.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IDA:BHF-UCL.
DR   GO; GO:0014050; P:negative regulation of glutamate secretion; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IDA:BHF-UCL.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; ISO:MGI.
DR   GO; GO:0045833; P:negative regulation of lipid metabolic process; IDA:BHF-UCL.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
DR   GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IEA:Ensembl.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IDA:MGI.
DR   GO; GO:0030728; P:ovulation; IEA:Ensembl.
DR   GO; GO:0019742; P:pentacyclic triterpenoid metabolic process; IEA:Ensembl.
DR   GO; GO:0030638; P:polyketide metabolic process; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0048711; P:positive regulation of astrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; ISO:MGI.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IDA:MGI.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IDA:BHF-UCL.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; ISO:MGI.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; ISO:MGI.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:MGI.
DR   GO; GO:0033092; P:positive regulation of immature T cell proliferation in thymus; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:MGI.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; ISO:MGI.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IDA:MGI.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IDA:MGI.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IDA:MGI.
DR   GO; GO:0043507; P:positive regulation of JUN kinase activity; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IDA:BHF-UCL.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; ISO:MGI.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; ISO:MGI.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; ISO:MGI.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; ISO:MGI.
DR   GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; ISO:MGI.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISO:MGI.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISO:MGI.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISO:MGI.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IDA:BHF-UCL.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
DR   GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISO:MGI.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IMP:BHF-UCL.
DR   GO; GO:0043491; P:protein kinase B signaling; ISO:MGI.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; ISO:MGI.
DR   GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; ISO:MGI.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISO:MGI.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IDA:UniProtKB.
DR   GO; GO:0033198; P:response to ATP; IDA:MGI.
DR   GO; GO:0009743; P:response to carbohydrate; IDA:MGI.
DR   GO; GO:0071548; P:response to dexamethasone; IEA:Ensembl.
DR   GO; GO:0036270; P:response to diuretic; IEA:Ensembl.
DR   GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR   GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR   GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR   GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0033591; P:response to L-ascorbic acid; IEA:Ensembl.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IDA:MGI.
DR   GO; GO:0043278; P:response to morphine; IEA:Ensembl.
DR   GO; GO:0010193; P:response to ozone; IEA:Ensembl.
DR   GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR   GO; GO:0036273; P:response to statin; IEA:Ensembl.
DR   GO; GO:0035634; P:response to stilbenoid; IEA:Ensembl.
DR   GO; GO:0033280; P:response to vitamin D; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; ISO:MGI.
DR   GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR   GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytokine; Cytoplasm;
KW   Cytoplasmic vesicle; Direct protein sequencing; Inflammatory response;
KW   Lysosome; Mitogen; Pyrogen; Reference proteome; Secreted.
FT   PROPEP        1    117       {ECO:0000269|PubMed:2967326}.
FT                                /FTId=PRO_0000015311.
FT   CHAIN       118    269       Interleukin-1 beta.
FT                                /FTId=PRO_0000015312.
FT   STRAND      123    129       {ECO:0000244|PDB:8I1B}.
FT   STRAND      134    138       {ECO:0000244|PDB:8I1B}.
FT   TURN        139    141       {ECO:0000244|PDB:8I1B}.
FT   STRAND      142    146       {ECO:0000244|PDB:8I1B}.
FT   HELIX       150    153       {ECO:0000244|PDB:8I1B}.
FT   STRAND      159    163       {ECO:0000244|PDB:8I1B}.
FT   STRAND      170    179       {ECO:0000244|PDB:8I1B}.
FT   STRAND      182    191       {ECO:0000244|PDB:8I1B}.
FT   STRAND      194    201       {ECO:0000244|PDB:8I1B}.
FT   TURN        204    206       {ECO:0000244|PDB:8I1B}.
FT   HELIX       214    216       {ECO:0000244|PDB:8I1B}.
FT   STRAND      217    223       {ECO:0000244|PDB:8I1B}.
FT   STRAND      226    234       {ECO:0000244|PDB:8I1B}.
FT   STRAND      238    241       {ECO:0000244|PDB:8I1B}.
FT   STRAND      243    248       {ECO:0000244|PDB:8I1B}.
FT   STRAND      250    252       {ECO:0000244|PDB:8I1B}.
FT   STRAND      256    259       {ECO:0000244|PDB:2MIB}.
FT   STRAND      262    266       {ECO:0000244|PDB:8I1B}.
SQ   SEQUENCE   269 AA;  30931 MW;  734FA17B02ED87EE CRC64;
     MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ ISQQHINKSF
     RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE PILCDSWDDD DNLLVCDVPI
     RQLHYRLRDE QQKSLVLSDP YELKALHLNG QNINQQVIFS MSFVQGEPSN DKIPVALGLK
     GKNLYLSCVM KDGTPTLQLE SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS
     TSQAEHKPVF LGNNSGQDII DFTMESVSS
//
ID   IL1B_MUSPF              Reviewed;         270 AA.
AC   A4UYK8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   17-FEB-2016, entry version 40.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=IL1B;
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Nakata M., Itou T., Sakai T.;
RT   "Mustela putorius furo interleukin-1 beta.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB301555; BAF56967.1; -; mRNA.
DR   RefSeq; NP_001297129.1; NM_001310200.1.
DR   ProteinModelPortal; A4UYK8; -.
DR   SMR; A4UYK8; 119-270.
DR   STRING; 9669.ENSMPUP00000010696; -.
DR   GeneID; 101688006; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; A4UYK8; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle;
KW   Inflammatory response; Lysosome; Mitogen; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    118       {ECO:0000250}.
FT                                /FTId=PRO_0000311173.
FT   CHAIN       119    270       Interleukin-1 beta.
FT                                /FTId=PRO_5000237424.
SQ   SEQUENCE   270 AA;  30982 MW;  682FB8EC4F76D35B CRC64;
     MARVPEPTSE VMSYGYSDNE NDLFFEADGP GKMKCCFQDL NNSYLEEEGI QLQISHQLHN
     KSLSHFVSVI VALEKLKKIS VPCSLPLQGD DLMNVFHCIF EEEPIILEKC DDNAFVHDAP
     PRSLDCKFQD INQKSLVLYN SYELRALHLN GTSVNQQAVF RMTFVQEDED ITKIPVALCI
     KEKNLYLSCV MKDGKPTLQL EMLDPKVYPK KRMEKRFVFN KTEIKKKVEF ESSQFPNWYI
     STSQAEAMPV FLGNNRGGHD ITDFTMELSS
//
ID   IL1B_PIG                Reviewed;         267 AA.
AC   P26889;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   08-JUN-2016, entry version 100.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=IL1B;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8325511; DOI=10.1016/0378-1119(93)90281-7;
RA   Huether M.J., Lin G., Smith D.M., Murtaugh M.P., Molitor T.W.;
RT   "Cloning, sequencing and regulation of an mRNA encoding porcine
RT   interleukin-1 beta.";
RL   Gene 129:285-289(1993).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; M86725; AAA02584.1; -; mRNA.
DR   PIR; JN0724; JN0724.
DR   RefSeq; NP_999220.1; NM_214055.1.
DR   UniGene; Ssc.28829; -.
DR   ProteinModelPortal; P26889; -.
DR   SMR; P26889; 115-266.
DR   STRING; 9823.ENSSSCP00000008636; -.
DR   PaxDb; P26889; -.
DR   Ensembl; ENSSSCT00000008861; ENSSSCP00000008636; ENSSSCG00000008088.
DR   GeneID; 397122; -.
DR   KEGG; ssc:397122; -.
DR   CTD; 397122; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; P26889; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-SSC-446652; Interleukin-1 signaling.
DR   Reactome; R-SSC-448706; Interleukin-1 processing.
DR   Reactome; R-SSC-5660668; CLEC7A/inflammasome pathway.
DR   Proteomes; UP000008227; Chromosome 3.
DR   Genevisible; P26889; SS.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:2000866; P:positive regulation of estradiol secretion; IDA:CACAO.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle;
KW   Inflammatory response; Lysosome; Mitogen; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    114       {ECO:0000250}.
FT                                /FTId=PRO_0000015313.
FT   CHAIN       115    267       Interleukin-1 beta.
FT                                /FTId=PRO_0000015314.
SQ   SEQUENCE   267 AA;  30404 MW;  7F6B92B784D5086F CRC64;
     MAIVPEPAKE VMANYGDNNN DLLFEADGPK EMKCCTQNLD LGSLRNGSIQ LQISHQLWNK
     SIRQMVSVIV AVEKPMKNPS SQAFCDDDQK SIFSFIFEEE PIILETCNDD FVCDANVQSM
     ECKLQDKDHK SLVLAGPHML KALHLLTGDL KREVVFCMSF VQGDDSNNKI PVTLGIKGKN
     LYLSCVMKDN TPTLQLEDID PKRYPKRDME KRFVFYKTEI KNRVEFESAL YPNWYISTSQ
     AEQKPVFLGN SKGRQDITDF TMEVLSP
//
ID   IL1B_RABIT              Reviewed;         268 AA.
AC   P14628;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   09-DEC-2015, entry version 91.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   AltName: Full=Lymphocyte proliferation-potentiating factor;
DE   Flags: Precursor;
GN   Name=IL1B;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2784458;
RA   Cannon J.G., Clark B.D., Wingfield P., Schmeissner U., Losberger C.,
RA   Dinarello C.A., Shaw A.R.;
RT   "Rabbit IL-1. Cloning, expression, biologic properties, and
RT   transcription during endotoxemia.";
RL   J. Immunol. 142:2299-2306(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2449207; DOI=10.1016/0006-291X(88)90761-9;
RA   Mori S., Goto F., Goto K., Ohkawara S., Maeda S., Shimada K.,
RA   Yoshinaga M.;
RT   "Cloning and sequence analysis of a cDNA for lymphocyte proliferation
RT   potentiating factor of rabbit polymorphonuclear leukocytes:
RT   identification rabbit interleukin 1 beta.";
RL   Biochem. Biophys. Res. Commun. 150:1237-1243(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2787507; DOI=10.1093/protein/2.7.545;
RA   Young P.R., Sylvester D.;
RT   "Cloning of rabbit interleukin-1 beta: differential evolution of IL-1
RT   alpha and IL-1 beta proteins.";
RL   Protein Eng. 2:545-551(1989).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; D21835; BAA04863.1; -; mRNA.
DR   EMBL; M26295; AAA31373.1; -; mRNA.
DR   PIR; A27714; A30584.
DR   RefSeq; NP_001075670.1; NM_001082201.1.
DR   UniGene; Ocu.1993; -.
DR   ProteinModelPortal; P14628; -.
DR   SMR; P14628; 118-268.
DR   STRING; 9986.ENSOCUP00000021869; -.
DR   GeneID; 100008990; -.
DR   KEGG; ocu:100008990; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; P14628; -.
DR   KO; K04519; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle;
KW   Inflammatory response; Lysosome; Mitogen; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    116
FT                                /FTId=PRO_0000015315.
FT   CHAIN       117    268       Interleukin-1 beta.
FT                                /FTId=PRO_0000015316.
SQ   SEQUENCE   268 AA;  30665 MW;  55BF44DD78D1B297 CRC64;
     MATVPELTSE MMAYHSGNEN DLFFEADGPN YMKSCFQDLD LCCPDEGIQL RISCQPYNKS
     FRQVLSVVVA LEKLRQKAVP CPQAFQDDGL RTFFSLIFEE EPVLCNTWDD YSLECDAVRS
     LHCRLQDAQQ KSLVLSGTYE LKALHLNAEN LNQQVVFSMS FVQGEESNDK IPVALGLRGK
     NLYLSCVMKD DKPTLQLESV DPNRYPKKKM EKRFVFNKIE IKDKLEFESA QFPNWYISTS
     QTEYMPVFLG NNSGGQDLID FSMEFVSS
//
ID   IL1B_RAT                Reviewed;         268 AA.
AC   Q63264;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   06-JUL-2016, entry version 112.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=Il1b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Macrophage;
RA   Feeser W., Freimark B.D.;
RL   Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; M98820; AAA41426.1; -; mRNA.
DR   UniGene; Rn.9869; -.
DR   ProteinModelPortal; Q63264; -.
DR   SMR; Q63264; 119-267.
DR   STRING; 10116.ENSRNOP00000006308; -.
DR   PaxDb; Q63264; -.
DR   PRIDE; Q63264; -.
DR   UCSC; RGD:2891; rat.
DR   RGD; 2891; Il1b.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   InParanoid; Q63264; -.
DR   PhylomeDB; Q63264; -.
DR   PRO; PR:Q63264; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IDA:RGD.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0002526; P:acute inflammatory response; IEP:RGD.
DR   GO; GO:0071236; P:cellular response to antibiotic; IEP:RGD.
DR   GO; GO:0071398; P:cellular response to fatty acid; IEP:RGD.
DR   GO; GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
DR   GO; GO:0071396; P:cellular response to lipid; IEP:RGD.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0002439; P:chronic inflammatory response to antigenic stimulus; IEP:RGD.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001660; P:fever generation; IEP:RGD.
DR   GO; GO:0007611; P:learning or memory; IEP:RGD.
DR   GO; GO:0007613; P:memory; IMP:RGD.
DR   GO; GO:2000173; P:negative regulation of branching morphogenesis of a nerve; IDA:RGD.
DR   GO; GO:0010629; P:negative regulation of gene expression; IDA:RGD.
DR   GO; GO:0014050; P:negative regulation of glutamate secretion; IMP:RGD.
DR   GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IDA:RGD.
DR   GO; GO:0050768; P:negative regulation of neurogenesis; IDA:RGD.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IDA:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:RGD.
DR   GO; GO:0030728; P:ovulation; IEP:RGD.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
DR   GO; GO:0048711; P:positive regulation of astrocyte differentiation; IDA:RGD.
DR   GO; GO:0010942; P:positive regulation of cell death; IDA:RGD.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:RGD.
DR   GO; GO:0045687; P:positive regulation of glial cell differentiation; IDA:RGD.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:RGD.
DR   GO; GO:0033092; P:positive regulation of immature T cell proliferation in thymus; IDA:RGD.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IDA:RGD.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IDA:RGD.
DR   GO; GO:0043507; P:positive regulation of JUN kinase activity; IMP:RGD.
DR   GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
DR   GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IMP:RGD.
DR   GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IDA:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.
DR   GO; GO:0071548; P:response to dexamethasone; IEP:RGD.
DR   GO; GO:0042493; P:response to drug; IEP:RGD.
DR   GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR   GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR   GO; GO:0010332; P:response to gamma radiation; IEP:RGD.
DR   GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
DR   GO; GO:0009408; P:response to heat; IEP:RGD.
DR   GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR   GO; GO:0035902; P:response to immobilization stress; IEP:RGD.
DR   GO; GO:0033591; P:response to L-ascorbic acid; IEP:RGD.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0043278; P:response to morphine; IEP:RGD.
DR   GO; GO:0007584; P:response to nutrient; IEP:RGD.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR   GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
DR   GO; GO:0010193; P:response to ozone; IEP:RGD.
DR   GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
DR   GO; GO:0035634; P:response to stilbenoid; IEP:RGD.
DR   GO; GO:0033280; P:response to vitamin D; IEP:RGD.
DR   GO; GO:0035176; P:social behavior; IMP:RGD.
DR   GO; GO:0042060; P:wound healing; IEP:RGD.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle;
KW   Inflammatory response; Lysosome; Mitogen; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    116       {ECO:0000250}.
FT                                /FTId=PRO_0000015317.
FT   CHAIN       117    268       Interleukin-1 beta.
FT                                /FTId=PRO_0000015318.
SQ   SEQUENCE   268 AA;  30644 MW;  109C19EBF69C242D CRC64;
     MATVPELNCE IAAFDSEEND LFFEADRPQK IKDCFQALDL GCPDESIQLQ ISQQHLDKSF
     RKAVSLIVAV EKLWQLPMSC PWSFQDEDPS TFFSFIFEEE PVLCDSWDDD DLLVCDVPIR
     QLHCRLRDEQ QKCLVLSDPC ELKALHLNGQ NISQQVVFSM SFVQGETSND KIPVALGLKG
     LNLYLSCVMK DGTPTLQLES VDPKQYPKKK MEKRFVFNKI EVKTKVEFES AQFPNWYIST
     SQAEHRPVFL GNSNGRDIVD FTMEPVSS
//
ID   IL1B_SHEEP              Reviewed;         266 AA.
AC   P21621;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 2.
DT   09-DEC-2015, entry version 89.
DE   RecName: Full=Interleukin-1 beta;
DE            Short=IL-1 beta;
DE   Flags: Precursor;
GN   Name=IL1B;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Alveolar macrophage;
RX   PubMed=2263490; DOI=10.1093/nar/18.23.7165;
RA   Fiskerstrand C., Sargan D.;
RT   "Nucleotide sequence of ovine interleukin-1 beta.";
RL   Nucleic Acids Res. 18:7165-7165(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1840515;
RA   Seow H.F., Rothel J.S., David M.J., Wood P.R.;
RT   "Nucleotide sequence of ovine macrophage interleukin-1 beta cDNA.";
RL   DNA Seq. 1:423-426(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1769692;
RA   Andrews A.E., Barcham G.J., Brandon M.R., Nash A.D.;
RT   "Molecular cloning and characterization of ovine IL-1 alpha and IL-1
RT   beta.";
RL   Immunology 74:453-460(1991).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with MEFV (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P10749}. Lysosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted, exosome
CC       {ECO:0000250|UniProtKB:P10749}. Cytoplasmic vesicle, autophagosome
CC       {ECO:0000250|UniProtKB:P01584}. Secreted
CC       {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic.
CC       In response to inflammasome-activating signals, such as ATP for
CC       NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome,
CC       cleaved and secreted. IL1B lacks any known signal sequence and the
CC       pathway(s) of its secretion is(are) not yet fully understood. On
CC       the basis of experimental results, several unconventional
CC       secretion mechanisms have been proposed. 1. Secretion via
CC       secretory lysosomes: a fraction of CASP1 and IL1B precursor may be
CC       incorporated, by a yet undefined mechanism, into secretory
CC       lysosomes that undergo Ca(2+)-dependent exocytosis with release of
CC       mature IL1B. 2. Secretory autophagy: IL1B-containing
CC       autophagosomes may fuse with endosomes or multivesicular bodies
CC       (MVBs) and then merge with the plasma membrane releasing soluble
CC       IL1B or IL1B-containing exosomes. However, autophagy impacts IL1B
CC       production at several levels and its role in secretion is still
CC       controversial. 3. Secretion via exosomes: ATP-activation of P2RX7
CC       leads to the formation of MVBs containing exosomes with entrapped
CC       IL1B, CASP1 and other inflammasome components. These MVBs undergo
CC       exocytosis with the release of exosomes. The release of soluble
CC       IL1B occurs after the lysis of exosome membranes. 4. Secretion by
CC       microvesicle shedding: activation of the ATP receptor P2RX7 may
CC       induce an immediate shedding of membrane-derived microvesicles
CC       containing IL1B and possibly inflammasome components. The cytokine
CC       is then released in the extracellular compartment after
CC       microvesicle lysis. 5. Release by translocation through
CC       permeabilized plasma membrane. This may occur in cells undergoing
CC       pyroptosis due to sustained activation of the inflammasome. These
CC       mechanisms may not be not mutually exclusive.
CC       {ECO:0000250|UniProtKB:P01584, ECO:0000250|UniProtKB:P10749}.
CC   -!- MISCELLANEOUS: IL1B production occurs in 2 steps, each being
CC       controlled by different stimuli. First, inflammatory signals, such
CC       as LPS, stimulate the synthesis and promote the accumulation of
CC       cytosolic stores of pro-IL1B (priming). Then additional signals
CC       are required for inflammasome assembly, leading to CASP1
CC       activation, pro-IL1B processing and eventually secretion of the
CC       active cytokine. IL1B processing and secretion are temporarily
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; X54796; CAA38566.1; -; mRNA.
DR   EMBL; X56972; CAA40293.1; -; mRNA.
DR   PIR; S23010; S23010.
DR   RefSeq; NP_001009465.2; NM_001009465.2.
DR   UniGene; Oar.434; -.
DR   ProteinModelPortal; P21621; -.
DR   SMR; P21621; 114-265.
DR   GeneID; 443539; -.
DR   KEGG; oas:443539; -.
DR   CTD; 3553; -.
DR   HOVERGEN; HBG007328; -.
DR   KO; K04519; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; TAS:AgBase.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0050691; P:regulation of defense response to virus by host; TAS:AgBase.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle;
KW   Inflammatory response; Lysosome; Mitogen; Pyrogen; Reference proteome;
KW   Secreted.
FT   PROPEP        1    113
FT                                /FTId=PRO_0000015319.
FT   CHAIN       114    266       Interleukin-1 beta.
FT                                /FTId=PRO_0000015320.
FT   CONFLICT     14     14       Y -> C (in Ref. 1; CAA38566).
FT                                {ECO:0000305}.
FT   CONFLICT     55     55       Q -> K (in Ref. 1; CAA38566).
FT                                {ECO:0000305}.
FT   CONFLICT     64     64       V -> A (in Ref. 1; CAA38566).
FT                                {ECO:0000305}.
FT   CONFLICT    145    145       P -> L (in Ref. 1 and 3). {ECO:0000305}.
SQ   SEQUENCE   266 AA;  30717 MW;  BDED07B58224AB78 CRC64;
     MATVPEPINE VMAYYSDENE LLFEVDGPKQ MKSCTQHLDL GSMGDGNIQL QISHQLYNKS
     FRQVVSVIVA MEKLRSRAYE HVFRDDDLRS ILSFIFEEEP VIFETSSDEL LCDAAVQSVK
     CKLQDREQKS LVLDSPCVLK ALHLPSQEMS REVVFCMSFV QGEERDNKIP VALGIRDKNL
     YLSCVKKGDT PTLQLEEVDP KVYPKRNMEK RFVFYKTEIK NTVEFESVLY PNWYISTSQI
     EEKPVFLGRF RGGQDITDFR METLSP
//
ID   IL1FA_HUMAN             Reviewed;         152 AA.
AC   Q8WWZ1; Q53SR9; Q56AT8; Q7RTZ5; Q969H5; Q9BYX1;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   08-JUN-2016, entry version 119.
DE   RecName: Full=Interleukin-1 family member 10;
DE            Short=IL-1F10;
DE   AltName: Full=Family of interleukin 1-theta;
DE            Short=FIL1 theta;
DE   AltName: Full=Interleukin-1 HY2;
DE            Short=IL-1HY2;
DE   AltName: Full=Interleukin-1 theta;
DE            Short=IL-1 theta;
DE   AltName: Full=Interleukin-38;
DE            Short=IL-38;
GN   Name=IL1F10; Synonyms=FIL1T, IL1HY2, IL38;
GN   ORFNames=FKSG75, UNQ6119/PRO20041;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Thymus;
RX   PubMed=11747621; DOI=10.1089/107999001753289505;
RA   Bensen J.T., Dawson P.A., Mychaleckyj J.C., Bowden D.W.;
RT   "Identification of a novel human cytokine gene in the interleukin gene
RT   cluster on chromosome 2q12-14.";
RL   J. Interferon Cytokine Res. 21:899-904(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA   Wang Y.-G., Li T., Gong L.;
RT   "Identification and characterization of FKSG75, a novel member of the
RT   interleukin-1 family.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND VARIANTS
RP   THR-44 AND ASP-51.
RC   TISSUE=Fetal skin;
RX   PubMed=11278614; DOI=10.1074/jbc.M010095200;
RA   Lin H., Ho A.S., Haley-Vicente D., Zhang J., Bernal-Fussell J.,
RA   Pace A.M., Hansen D., Schweighofer K., Mize N.K., Ford J.E.;
RT   "Cloning and characterization of IL1HY2, a novel interleukin-1 family
RT   member.";
RL   J. Biol. Chem. 276:20597-20602(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-44 AND ASP-51.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS THR-44 AND
RP   ASP-51.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   FUNCTION.
RX   PubMed=22315422; DOI=10.1073/pnas.1121534109;
RA   van de Veerdonk F.L., Stoeckman A.K., Wu G., Boeckermann A.N.,
RA   Azam T., Netea M.G., Joosten L.A., van der Meer J.W., Hao R.,
RA   Kalabokis V., Dinarello C.A.;
RT   "IL-38 binds to the IL-36 receptor and has biological effects on
RT   immune cells similar to IL-36 receptor antagonist.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:3001-3005(2012).
RN   [10]
RP   VARIANTS THR-44 AND ASP-51.
RX   PubMed=11991723; DOI=10.1006/geno.2002.6752;
RA   Taylor S.L., Renshaw B.R., Garka K.E., Smith D.E., Sims J.E.;
RT   "Genomic organization of the interleukin-1 locus.";
RL   Genomics 79:726-733(2002).
CC   -!- FUNCTION: Cytokine with immunomodulatory activity. Alone, does not
CC       induce cytokine production, but reduces IL22 and IL17A production
CC       by T-cells in response to heat-killed Candida albicans. Reduces
CC       IL36G-induced production of IL8 by peripheral blood mononuclear
CC       cells. Increases IL6 production by dendritic cells stimulated by
CC       bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
CC       {ECO:0000269|PubMed:22315422}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8WWZ1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8WWZ1-2; Sequence=VSP_002658;
CC         Note=No experimental confirmation available.;
CC   -!- TISSUE SPECIFICITY: Expressed in fetal skin, spleen and tonsil.
CC       Expressed mostly in the basal epithelia of skin and in
CC       proliferating B-cells of the tonsil.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="https://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1f10/";
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AY029413; AAK33010.1; -; mRNA.
DR   EMBL; AY026753; AAK01948.1; -; mRNA.
DR   EMBL; AF334755; AAK68048.1; -; mRNA.
DR   EMBL; AF334756; AAK68049.1; -; Genomic_DNA.
DR   EMBL; BN000002; CAD29878.1; -; Genomic_DNA.
DR   EMBL; AY358846; AAQ89205.1; -; mRNA.
DR   EMBL; AY972854; AAX59032.1; -; Genomic_DNA.
DR   EMBL; AC016724; AAY14991.1; -; Genomic_DNA.
DR   EMBL; BC103966; AAI03967.1; -; mRNA.
DR   EMBL; BC103967; AAI03968.1; -; mRNA.
DR   EMBL; BC103968; AAI03969.1; -; mRNA.
DR   CCDS; CCDS2112.1; -. [Q8WWZ1-1]
DR   RefSeq; NP_115945.4; NM_032556.5. [Q8WWZ1-1]
DR   RefSeq; NP_775184.1; NM_173161.2. [Q8WWZ1-1]
DR   UniGene; Hs.306974; -.
DR   ProteinModelPortal; Q8WWZ1; -.
DR   SMR; Q8WWZ1; 18-150.
DR   BioGrid; 124164; 1.
DR   STRING; 9606.ENSP00000341794; -.
DR   iPTMnet; Q8WWZ1; -.
DR   BioMuta; IL1F10; -.
DR   DMDM; 25008589; -.
DR   PaxDb; Q8WWZ1; -.
DR   PeptideAtlas; Q8WWZ1; -.
DR   PRIDE; Q8WWZ1; -.
DR   Ensembl; ENST00000341010; ENSP00000341794; ENSG00000136697. [Q8WWZ1-1]
DR   Ensembl; ENST00000393197; ENSP00000376893; ENSG00000136697. [Q8WWZ1-1]
DR   GeneID; 84639; -.
DR   KEGG; hsa:84639; -.
DR   UCSC; uc002tiu.4; human. [Q8WWZ1-1]
DR   CTD; 84639; -.
DR   GeneCards; IL1F10; -.
DR   HGNC; HGNC:15552; IL1F10.
DR   HPA; HPA059813; -.
DR   MIM; 615296; gene.
DR   neXtProt; NX_Q8WWZ1; -.
DR   PharmGKB; PA38387; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; Q8WWZ1; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   PhylomeDB; Q8WWZ1; -.
DR   TreeFam; TF300203; -.
DR   GeneWiki; IL1F10; -.
DR   GenomeRNAi; 84639; -.
DR   PRO; PR:Q8WWZ1; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; Q8WWZ1; -.
DR   CleanEx; HS_IL1F10; -.
DR   Genevisible; Q8WWZ1; HS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Cytokine; Polymorphism;
KW   Reference proteome; Secreted.
FT   CHAIN         1    152       Interleukin-1 family member 10.
FT                                /FTId=PRO_0000153650.
FT   VAR_SEQ       9     39       YYIIKYADQKALYTRDGQLLVGDPVADNCCA -> MSSSFL
FT                                PEPLPAKSLQHGVPLSLDSSLSSLL (in isoform 2).
FT                                {ECO:0000303|Ref.2}.
FT                                /FTId=VSP_002658.
FT   VARIANT      44     44       I -> T (in dbSNP:rs6761276).
FT                                {ECO:0000269|PubMed:11278614,
FT                                ECO:0000269|PubMed:11991723,
FT                                ECO:0000269|PubMed:15489334,
FT                                ECO:0000269|Ref.6}.
FT                                /FTId=VAR_014262.
FT   VARIANT      51     51       A -> D (in dbSNP:rs6743376).
FT                                {ECO:0000269|PubMed:11278614,
FT                                ECO:0000269|PubMed:11991723,
FT                                ECO:0000269|PubMed:15489334,
FT                                ECO:0000269|Ref.6}.
FT                                /FTId=VAR_014263.
SQ   SEQUENCE   152 AA;  16943 MW;  E0ABD2496551B34F CRC64;
     MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICILPNRGL ARTKVPIFLG
     IQGGSRCLAC VETEEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAAWPGW
     FLCGPAEPQQ PVQLTKESEP SARTKFYFEQ SW
//
ID   IL1FA_MOUSE             Reviewed;         152 AA.
AC   Q8R459;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   06-JUL-2016, entry version 104.
DE   RecName: Full=Interleukin-1 family member 10;
DE            Short=IL-1F10;
GN   Name=Il1f10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Swiss Webster / NIH;
RX   PubMed=11991723; DOI=10.1006/geno.2002.6752;
RA   Taylor S.L., Renshaw B.R., Garka K.E., Smith D.E., Sims J.E.;
RT   "Genomic organization of the interleukin-1 locus.";
RL   Genomics 79:726-733(2002).
CC   -!- FUNCTION: Cytokine with immunomodulatory activity. Alone, does not
CC       induce cytokine production, but reduces IL22 and IL17A production
CC       by T-cells in response to heat-killed Candida albicans. Reduces
CC       IL36G-induced production of IL8 by peripheral blood mononuclear
CC       cells. Increases IL6 production by dendritic cells stimulated by
CC       bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AY071844; AAL67155.1; -; mRNA.
DR   CCDS; CCDS15735.1; -.
DR   RefSeq; NP_694717.1; NM_153077.2.
DR   RefSeq; XP_006497893.1; XM_006497830.1.
DR   UniGene; Mm.218750; -.
DR   ProteinModelPortal; Q8R459; -.
DR   SMR; Q8R459; 12-149.
DR   STRING; 10090.ENSMUSP00000063004; -.
DR   PaxDb; Q8R459; -.
DR   PRIDE; Q8R459; -.
DR   Ensembl; ENSMUST00000058056; ENSMUSP00000063004; ENSMUSG00000046845.
DR   GeneID; 215274; -.
DR   KEGG; mmu:215274; -.
DR   UCSC; uc008iou.1; mouse.
DR   CTD; 84639; -.
DR   MGI; MGI:2652548; Il1f10.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; Q8R459; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   PhylomeDB; Q8R459; -.
DR   TreeFam; TF300203; -.
DR   PRO; PR:Q8R459; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; Q8R459; -.
DR   CleanEx; MM_IL1F10; -.
DR   ExpressionAtlas; Q8R459; differential.
DR   Genevisible; Q8R459; MM.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Reference proteome; Secreted.
FT   CHAIN         1    152       Interleukin-1 family member 10.
FT                                /FTId=PRO_0000153651.
SQ   SEQUENCE   152 AA;  17078 MW;  9AD03EB0C3C61D8A CRC64;
     MCSLPMARYY IIKDAHQKAL YTRNGQLLLG DPDSDNYSPE KVCILPNRGL DRSKVPIFLG
     MQGGSCCLAC VKTREGPLLQ LEDVNIEDLY KGGEQTTRFT FFQRSLGSAF RLEAAACPGW
     FLCGPAEPQQ PVQLTKESEP STHTEFYFEM SR
//
ID   IL1RA_BOVIN             Reviewed;         174 AA.
AC   O77482;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   06-JUL-2016, entry version 105.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9643454; DOI=10.1016/S0165-2427(98)00099-3;
RA   Kirisawa R., Fukuda T., Yamanaka H., Hagiwara K., Goto M., Obata Y.,
RA   Yoshino T., Iwai H.;
RT   "Enzymatic amplification and expression of bovine interleukin-1
RT   receptor antagonist cDNA.";
RL   Vet. Immunol. Immunopathol. 62:197-208(1998).
CC   -!- FUNCTION: Inhibits the activity of interleukin-1 by binding to
CC       receptor IL1R1 and preventing its association with the coreceptor
CC       IL1RAP for signaling. Has no interleukin-1 like activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB005148; BAA31854.1; -; mRNA.
DR   RefSeq; NP_776782.1; NM_174357.3.
DR   UniGene; Bt.4199; -.
DR   ProteinModelPortal; O77482; -.
DR   SMR; O77482; 25-174.
DR   STRING; 9913.ENSBTAP00000026209; -.
DR   PaxDb; O77482; -.
DR   PeptideAtlas; O77482; -.
DR   Ensembl; ENSBTAT00000026209; ENSBTAP00000026209; ENSBTAG00000019665.
DR   GeneID; 281860; -.
DR   KEGG; bta:281860; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; O77482; -.
DR   KO; K05481; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-BTA-446652; Interleukin-1 signaling.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     23       {ECO:0000250}.
FT   CHAIN        24    174       Interleukin-1 receptor antagonist
FT                                protein.
FT                                /FTId=PRO_0000015325.
FT   CARBOHYD    107    107       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     89    139       {ECO:0000250}.
SQ   SEQUENCE   174 AA;  19926 MW;  1E56E7F224FF851F CRC64;
     MDIYIHGYLI CLLLFLFRSE TACHPLGKRR CEMQAFRIWD VNQKIFYLRN NQLVAGYLQG
     PNTKLEEKID VVPIEPHTMF LGIHGGKLCL ACVKSGDEIK LKLEAVNITD LNQNREQDKR
     FAFIRFDNGP TTSFESAACP GWFLCTSLEA DQPVGLTNMP TEALKVTKFY FQQD
//
ID   IL1RA_CANLF             Reviewed;         176 AA.
AC   Q9BEH0; Q9GKK2;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   08-JUN-2016, entry version 98.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Shin I.-S., Youn H.-Y.;
RT   "Molecular cloning of canine interleukin-1 receptor antagonist (IL-
RT   1ra).";
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11182158; DOI=10.1016/S0165-2427(00)00261-0;
RA   Campbell S.E., Nasir L., Argyle D.J., Gault E.A., Duthie S.,
RA   Bennett D.;
RT   "Cloning of canine IL-1ra, TNFR and TIMP-2.";
RL   Vet. Immunol. Immunopathol. 78:207-214(2001).
CC   -!- FUNCTION: Inhibits the activity of interleukin-1 by binding to
CC       receptor IL1R1 and preventing its association with the coreceptor
CC       IL1RAP for signaling. Has no interleukin-1 like activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; AY026462; AAK01472.1; -; mRNA.
DR   EMBL; AF216526; AAG36777.1; -; mRNA.
DR   RefSeq; NP_001003096.1; NM_001003096.1.
DR   UniGene; Cfa.3496; -.
DR   ProteinModelPortal; Q9BEH0; -.
DR   SMR; Q9BEH0; 26-176.
DR   STRING; 9615.ENSCAFP00000010796; -.
DR   PaxDb; Q9BEH0; -.
DR   Ensembl; ENSCAFT00000011651; ENSCAFP00000010796; ENSCAFG00000007277.
DR   Ensembl; ENSCAFT00000043065; ENSCAFP00000036995; ENSCAFG00000007277.
DR   GeneID; 403660; -.
DR   KEGG; cfa:403660; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; Q9BEH0; -.
DR   KO; K05481; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-CFA-446652; Interleukin-1 signaling.
DR   Proteomes; UP000002254; Chromosome 17.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     25       {ECO:0000255}.
FT   CHAIN        26    176       Interleukin-1 receptor antagonist
FT                                protein.
FT                                /FTId=PRO_0000015326.
FT   CARBOHYD    109    109       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     91    141       {ECO:0000250}.
FT   CONFLICT    155    155       P -> L (in Ref. 2; AAG36777).
FT                                {ECO:0000305}.
SQ   SEQUENCE   176 AA;  19922 MW;  8486CA54A240212B CRC64;
     METCRCPLSY LISFLLFLSH SETACRPLGK RPCRMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGSNTKLEEK LDVVPVEPHA VFLGIHGGKL CLACVKSGDE TRLQLEAVNI TDLSKNKDQD
     KRFTFILSDS GPTTSFESAA CPGWFLCTAL EADRPVSLTN RPEEAMMVTK FYFQKE
//
ID   IL1RA_HORSE             Reviewed;         177 AA.
AC   O18999; O77745; Q9TSJ0;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   08-JUN-2016, entry version 101.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN; Synonyms=IL1RA;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9223227; DOI=10.1016/S0165-2427(96)05769-8;
RA   Kato H., Ohashi T., Matsushiro H., Watari T., Goitsuka R.,
RA   Tsujimoto H., Hasegawa A.;
RT   "Molecular cloning and functional expression of equine interleukin-1
RT   receptor antagonist.";
RL   Vet. Immunol. Immunopathol. 56:221-231(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9622739;
RA   Howard R.D., McIlwraith C.W., Trotter G.W., Nyborg J.K.;
RT   "Cloning of equine interleukin-1 receptor antagonist and determination
RT   of its full-length cDNA sequence.";
RL   Am. J. Vet. Res. 59:712-716(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-119.
RA   Dhar A.K., Thompson M.S., Paradis M.R., Alcivar-Warren A.;
RT   "Molecular characterization of equine interleukin 1 receptor
RT   antagonist (IL-1ra) gene.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits the activity of interleukin-1 by binding to
CC       receptor IL1R1 and preventing its association with the coreceptor
CC       IL1RAP for signaling. Has no interleukin-1 like activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; D83714; BAA22529.1; -; mRNA.
DR   EMBL; U92482; AAC39257.1; -; mRNA.
DR   EMBL; AF088186; AAD04132.1; -; mRNA.
DR   RefSeq; NP_001075994.1; NM_001082525.2.
DR   UniGene; Eca.13123; -.
DR   UniGene; Eca.18515; -.
DR   ProteinModelPortal; O18999; -.
DR   SMR; O18999; 27-177.
DR   STRING; 9796.ENSECAP00000004056; -.
DR   PaxDb; O18999; -.
DR   GeneID; 100034236; -.
DR   KEGG; ecb:100034236; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; O18999; -.
DR   KO; K05481; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     25       {ECO:0000250}.
FT   CHAIN        26    177       Interleukin-1 receptor antagonist
FT                                protein.
FT                                /FTId=PRO_0000015327.
FT   CARBOHYD    109    109       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     91    141       {ECO:0000250}.
FT   CONFLICT     19     19       F -> L (in Ref. 2; AAC39257).
FT                                {ECO:0000305}.
FT   CONFLICT     66     66       Missing (in Ref. 3; AAD04132).
FT                                {ECO:0000305}.
SQ   SEQUENCE   177 AA;  20460 MW;  1ABC377F1F1CF80B CRC64;
     MEIRRRSVRH LISLLLFLFY SETACHPLGK RPCKMQAFRI WDVNQKTFYM RNNQLVAGYL
     QESNTKLQEK IDVVPIEPDA LFLGLHGRKL CLACVKSGDE IRFQLEAVNI TDLSKNKEEN
     KRFTFIRSNS GPTTSFESAA CPGWFLCTAQ EADRPVSLTN KPKESFMVTK FYLQEDQ
//
ID   IL1RA_HUMAN             Reviewed;         177 AA.
AC   P18510; A8K4G1; Q14628; Q53SC2; Q7RTZ4; Q96GD6; Q9UPC0;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   06-JUL-2016, entry version 188.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=ICIL-1RA;
DE   AltName: Full=IL1 inhibitor;
DE   AltName: INN=Anakinra;
DE   Flags: Precursor;
GN   Name=IL1RN; Synonyms=IL1F3, IL1RA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=2139180; DOI=10.1038/344633a0;
RA   Carter D.B., Deibel M.R. Jr., Dunn C.J., Tomich C.S.C., Laborde A.L.,
RA   Slightom J.L., Berger A.E., Bienkowski M.J., Sun F.F., McEwan R.N.,
RA   Harris P.K.W., Yem A.W., Waszak G.A., Chosay J.G., Sieu L.C.,
RA   Hardee M.M., Zurcher-Neely H.A., Reardon I.M., Heinrikson R.L.,
RA   Truesdell S.E., Shelly J.A., Eessalu T.E., Taylor B.M., Tracey D.E.;
RT   "Purification, cloning, expression and biological characterization of
RT   an interleukin-1 receptor antagonist protein.";
RL   Nature 344:633-638(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=2137201; DOI=10.1038/343341a0;
RA   Eisenberg S.P., Evans R.J., Arend W.P., Verderber E., Brewer M.T.,
RA   Hannum C.H., Thompson R.C.;
RT   "Primary structure and functional expression from complementary DNA of
RT   a human interleukin-1 receptor antagonist.";
RL   Nature 343:341-346(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX   PubMed=1828896; DOI=10.1073/pnas.88.12.5232;
RA   Eisenberg S.P., Brewer M.T., Verderber E., Heimdal P.,
RA   Brandhuber B.J., Thompson R.C.;
RT   "Interleukin 1 receptor antagonist is a member of the interleukin 1
RT   gene family: evolution of a cytokine control mechanism.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:5232-5236(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX   PubMed=1385987; DOI=10.1016/1043-4666(92)90041-O;
RA   Lennard A., Gorman P., Carrier M., Griffiths S., Scotney H., Sheer D.,
RA   Solari R.;
RT   "Cloning and chromosome mapping of the human interleukin-1 receptor
RT   antagonist gene.";
RL   Cytokine 4:83-89(1992).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3).
RX   PubMed=8992991;
RA   Jenkins J.K., Drong R.F., Shuck M.E., Bienkowski M.J., Slightom J.L.,
RA   Arend W.P., Smith M.F. Jr.;
RT   "Intracellular IL-1 receptor antagonist promoter: cell type-specific
RT   and inducible regulatory regions.";
RL   J. Immunol. 158:748-755(1997).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=1827201; DOI=10.1073/pnas.88.9.3681;
RA   Haskill S., Martin G., van Le L., Morris J., Peace A., Bigler C.F.,
RA   Jaffe G.J., Hammerberg C., Sporn S.A., Fong S., Arend W.P., Ralph P.;
RT   "cDNA cloning of an intracellular form of the human interleukin 1
RT   receptor antagonist associated with epithelium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:3681-3685(1991).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RX   PubMed=7629520; DOI=10.1084/jem.182.2.623;
RA   Muzio M., Polentarutti N., Sironi M., Poli G., De Gioia L.,
RA   Introna M., Mantovani A., Colotta F.;
RT   "Cloning and characterization of a new isoform of the interleukin 1
RT   receptor antagonist.";
RL   J. Exp. Med. 182:623-628(1995).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   SeattleSNPs variation discovery resource;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC   TISSUE=Esophagus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [11]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [12]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [13]
RP   PROTEIN SEQUENCE OF 26-45, AND GLYCOSYLATION AT ASN-109.
RX   PubMed=2137200; DOI=10.1038/343336a0;
RA   Hannum C.H., Wilcox C.J., Arend W.P., Joslin F.G., Dripps D.J.,
RA   Heimdal P.L., Armes L.G., Sommer A., Eisenberg S.P., Thompson R.C.;
RT   "Interleukin-1 receptor antagonist activity of a human interleukin-1
RT   inhibitor.";
RL   Nature 343:336-340(1990).
RN   [14]
RP   PROTEIN SEQUENCE OF 26-52.
RX   PubMed=2143761;
RA   Bienkowski M.J., Eessalu T.E., Berger A.E., Truesdell S.E.,
RA   Shelly J.A., Laborde A.L., Zurcher-Neely H.A., Reardon I.M.,
RA   Heinrikson R.L., Chosay J.G., Tracey D.E.;
RT   "Purification and characterization of interleukin 1 receptor level
RT   antagonist proteins from THP-1 cells.";
RL   J. Biol. Chem. 265:14505-14511(1990).
RN   [15]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 35-177 (ISOFORM 4).
RX   PubMed=9514884; DOI=10.1006/bbrc.1998.8217;
RA   Weissbach L., Tran K., Colquhoun S.A., Champliaud M.-F., Towle C.A.;
RT   "Detection of an interleukin-1 intracellular receptor antagonist mRNA
RT   variant.";
RL   Biochem. Biophys. Res. Commun. 244:91-95(1998).
RN   [16]
RP   RECEPTOR-BINDING.
RX   PubMed=7989776;
RA   Giri J.G., Wells J., Dower S.K., McCall C.E., Guzman R.N., Slack J.,
RA   Bird T.A., Shanebeck K., Grabstein K.H., Sims J.E., Alderson M.R.;
RT   "Elevated levels of shed type II IL-1 receptor in sepsis. Potential
RT   role for type II receptor in regulation of IL-1 responses.";
RL   J. Immunol. 153:5802-5809(1994).
RN   [17]
RP   FUNCTION.
RX   PubMed=7775431; DOI=10.1074/jbc.270.23.13757;
RA   Greenfeder S.A., Nunes P., Kwee L., Labow M., Chizzonite R.A., Ju G.;
RT   "Molecular cloning and characterization of a second subunit of the
RT   interleukin 1 receptor complex.";
RL   J. Biol. Chem. 270:13757-13765(1995).
RN   [18]
RP   IDENTIFICATION (ISOFORM 2).
RX   PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [19]
RP   INVOLVEMENT IN MVCD4.
RX   PubMed=8786086; DOI=10.1007/BF02185776;
RA   Blakemore A.I.F., Cox A., Gonzalez A.-M., Maskil J.K., Hughes M.E.,
RA   Wilson R.M., Ward J.D., Duff G.W.;
RT   "Interleukin-1 receptor antagonist allele (IL1RN*2) associated with
RT   nephropathy in diabetes mellitus.";
RL   Hum. Genet. 97:369-374(1996).
RN   [20]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-109.
RC   TISSUE=Plasma;
RX   PubMed=16335952; DOI=10.1021/pr0502065;
RA   Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,
RA   Moore R.J., Smith R.D.;
RT   "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT   hydrazide chemistry, and mass spectrometry.";
RL   J. Proteome Res. 4:2070-2080(2005).
RN   [21]
RP   INVOLVEMENT IN DIRA.
RX   PubMed=19494218; DOI=10.1056/NEJMoa0807865;
RA   Aksentijevich I., Masters S.L., Ferguson P.J., Dancey P., Frenkel J.,
RA   van Royen-Kerkhoff A., Laxer R., Tedgard U., Cowen E.W., Pham T.H.,
RA   Booty M., Estes J.D., Sandler N.G., Plass N., Stone D.L., Turner M.L.,
RA   Hill S., Butman J.A., Schneider R., Babyn P., El-Shanti H.I., Pope E.,
RA   Barron K., Bing X., Laurence A., Lee C.C., Chapelle D., Clarke G.I.,
RA   Ohson K., Nicholson M., Gadina M., Yang B., Korman B.D.,
RA   Gregersen P.K., van Hagen P.M., Hak A.E., Huizing M., Rahman P.,
RA   Douek D.C., Remmers E.F., Kastner D.L., Goldbach-Mansky R.;
RT   "An autoinflammatory disease with deficiency of the interleukin-1-
RT   receptor antagonist.";
RL   N. Engl. J. Med. 360:2426-2437(2009).
RN   [22]
RP   STRUCTURE BY NMR.
RX   PubMed=1534997; DOI=10.1021/bi00138a001;
RA   Stockman B.J., Scahill T.A., Roy M., Ulrich E.L., Strakalaitis N.A.,
RA   Brunner D.P., Yem A.W., Deibel M.R. Jr.;
RT   "Secondary structure and topology of interleukin-1 receptor antagonist
RT   protein determined by heteronuclear three-dimensional NMR
RT   spectroscopy.";
RL   Biochemistry 31:5237-5244(1992).
RN   [23]
RP   STRUCTURE BY NMR.
RX   PubMed=8045306; DOI=10.1016/0014-5793(94)00643-1;
RA   Stockman B.J., Scahill T.A., Strakalaitis N.A., Brunner D.P.,
RA   Yem A.W., Deibel M.R. Jr.;
RT   "Solution structure of human interleukin-1 receptor antagonist
RT   protein.";
RL   FEBS Lett. 349:79-83(1994).
RN   [24]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RX   PubMed=8175703;
RA   Vigers G.P.A., Caffes P., Evans R.J., Thompson R.C., Eisenberg S.P.,
RA   Brandhuber B.J.;
RT   "X-ray structure of interleukin-1 receptor antagonist at 2.0-A
RT   resolution.";
RL   J. Biol. Chem. 269:12874-12879(1994).
RN   [25]
RP   X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
RX   PubMed=7867645; DOI=10.1111/j.1432-1033.1995.tb20209.x;
RA   Schreuder H.A., Rondeau J.-M., Tardif C., Soffientini A., Sarubbi E.,
RA   Akeson A., Bowlin T.L., Yanofsky S., Barrett R.W.;
RT   "Refined crystal structure of the interleukin-1 receptor antagonist.
RT   Presence of a disulfide link and a cis-proline.";
RL   Eur. J. Biochem. 227:838-847(1995).
RN   [26]
RP   X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 32-177 IN COMPLEX WITH IL1R.
RX   PubMed=9062194; DOI=10.1038/386194a0;
RA   Schreuder H., Tardif C., Trump-Kallmeyer S., Soffientini A.,
RA   Sarubbi E., Akeson A., Bowlin T., Yanofsky S., Barrett R.W.;
RT   "A new cytokine-receptor binding mode revealed by the crystal
RT   structure of the IL-1 receptor with an antagonist.";
RL   Nature 386:194-200(1997).
RN   [27]
RP   VARIANT [LARGE SCALE ANALYSIS] THR-124.
RX   PubMed=18987736; DOI=10.1038/nature07485;
RA   Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K.,
RA   Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L.,
RA   Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A.,
RA   Abbott S., Locke D., Hillier L.W., Miner T., Fulton L., Magrini V.,
RA   Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R.,
RA   Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E.,
RA   Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J.,
RA   Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C.,
RA   Graubert T.A., DiPersio J.F., Wilson R.K.;
RT   "DNA sequencing of a cytogenetically normal acute myeloid leukaemia
RT   genome.";
RL   Nature 456:66-72(2008).
CC   -!- FUNCTION: Inhibits the activity of interleukin-1 by binding to
CC       receptor IL1R1 and preventing its association with the coreceptor
CC       IL1RAP for signaling. Has no interleukin-1 like activity. Binds
CC       functional interleukin-1 receptor IL1R1 with greater affinity than
CC       decoy receptor IL1R2; however, the physiological relevance of the
CC       latter association is unsure. {ECO:0000269|PubMed:7775431}.
CC   -!- INTERACTION:
CC       Q9NYB0:TERF2IP; NbExp=2; IntAct=EBI-1026330, EBI-750109;
CC   -!- SUBCELLULAR LOCATION: Isoform 1: Secreted.
CC   -!- SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.
CC   -!- SUBCELLULAR LOCATION: Isoform 3: Cytoplasm.
CC   -!- SUBCELLULAR LOCATION: Isoform 4: Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=P18510-1; Sequence=Displayed;
CC       Name=2; Synonyms=icIL-1ra;
CC         IsoId=P18510-2; Sequence=VSP_002649;
CC       Name=3; Synonyms=icIL-1ra type II;
CC         IsoId=P18510-3; Sequence=VSP_002650;
CC       Name=4;
CC         IsoId=P18510-4; Sequence=VSP_002651;
CC   -!- TISSUE SPECIFICITY: The intracellular form of IL1RN is
CC       predominantly expressed in epithelial cells.
CC   -!- DISEASE: Microvascular complications of diabetes 4 (MVCD4)
CC       [MIM:612628]: Pathological conditions that develop in numerous
CC       tissues and organs as a consequence of diabetes mellitus. They
CC       include diabetic retinopathy, diabetic nephropathy leading to end-
CC       stage renal disease, and diabetic neuropathy. Diabetic retinopathy
CC       remains the major cause of new-onset blindness among diabetic
CC       adults. It is characterized by vascular permeability and increased
CC       tissue ischemia and angiogenesis. {ECO:0000269|PubMed:8786086}.
CC       Note=Disease susceptibility is associated with variations
CC       affecting the gene represented in this entry.
CC   -!- DISEASE: Interleukin 1 receptor antagonist deficiency (DIRA)
CC       [MIM:612852]: A rare autoinflammatory disease of skin and bone
CC       resulting in sterile multifocal osteomyelitis, periostitis, and
CC       pustulosis from birth. The term autoinflammatory disease describes
CC       a group of disorders characterized by attacks of seemingly
CC       unprovoked inflammation without significant levels of
CC       autoantibodies and autoreactive T-cells.
CC       {ECO:0000269|PubMed:19494218}. Note=The disease is caused by
CC       mutations affecting the gene represented in this entry.
CC   -!- PHARMACEUTICAL: Available under the name Kineret (Amgen). Used for
CC       the reduction in signs and symptoms and slowing the progression of
CC       structural damage in moderately to severely active rheumatoid
CC       arthritis.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="https://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1rn/";
CC   -!- WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and
CC       polymorphism database;
CC       URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1RN";
CC   -!- WEB RESOURCE: Name=Kineret professional medical information";
CC       URL="http://www.rxlist.com/kineret-drug.htm";
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DR   EMBL; X53296; CAA37386.1; -; mRNA.
DR   EMBL; X52015; CAA36262.1; -; mRNA.
DR   EMBL; M63099; AAB41943.1; -; Genomic_DNA.
DR   EMBL; X64532; CAA45832.1; -; Genomic_DNA.
DR   EMBL; U65590; AAB92270.1; -; Genomic_DNA.
DR   EMBL; U65590; AAB92268.1; -; Genomic_DNA.
DR   EMBL; U65590; AAB92269.1; -; Genomic_DNA.
DR   EMBL; M55646; AAA59138.1; -; mRNA.
DR   EMBL; X84348; CAA59087.1; -; mRNA.
DR   EMBL; AY196903; AAN87150.1; -; Genomic_DNA.
DR   EMBL; AK290898; BAF83587.1; -; mRNA.
DR   EMBL; AK290926; BAF83615.1; -; mRNA.
DR   EMBL; AC024704; AAX93278.1; -; Genomic_DNA.
DR   EMBL; CH471217; EAW73625.1; -; Genomic_DNA.
DR   EMBL; BC009745; AAH09745.1; -; mRNA.
DR   EMBL; AF043143; AAC39672.1; -; mRNA.
DR   EMBL; BN000002; CAD29879.1; -; Genomic_DNA.
DR   CCDS; CCDS2113.1; -. [P18510-2]
DR   CCDS; CCDS2114.1; -. [P18510-3]
DR   CCDS; CCDS2115.1; -. [P18510-4]
DR   CCDS; CCDS46396.1; -. [P18510-1]
DR   PIR; A40956; A30368.
DR   PIR; I37893; A39386.
DR   RefSeq; NP_000568.1; NM_000577.4. [P18510-2]
DR   RefSeq; NP_001305843.1; NM_001318914.1. [P18510-4]
DR   RefSeq; NP_776213.1; NM_173841.2. [P18510-3]
DR   RefSeq; NP_776214.1; NM_173842.2. [P18510-1]
DR   RefSeq; NP_776215.1; NM_173843.2. [P18510-4]
DR   RefSeq; XP_005263718.1; XM_005263661.3. [P18510-4]
DR   RefSeq; XP_011509423.1; XM_011511121.1. [P18510-4]
DR   UniGene; Hs.81134; -.
DR   PDB; 1ILR; X-ray; 2.10 A; 1/2=26-177.
DR   PDB; 1ILT; X-ray; 2.00 A; A/B=26-177.
DR   PDB; 1IRA; X-ray; 2.70 A; X=26-177.
DR   PDB; 1IRP; NMR; -; A=26-177.
DR   PDB; 1ITN; Model; -; A=31-177.
DR   PDB; 2IRT; X-ray; 3.20 A; A/B=26-177.
DR   PDBsum; 1ILR; -.
DR   PDBsum; 1ILT; -.
DR   PDBsum; 1IRA; -.
DR   PDBsum; 1IRP; -.
DR   PDBsum; 1ITN; -.
DR   PDBsum; 2IRT; -.
DR   ProteinModelPortal; P18510; -.
DR   SMR; P18510; 33-177.
DR   BioGrid; 109772; 10.
DR   IntAct; P18510; 3.
DR   MINT; MINT-1522172; -.
DR   STRING; 9606.ENSP00000259206; -.
DR   DrugBank; DB06372; Rilonacept.
DR   Allergome; 11858; Hom s Anakinra.
DR   BioMuta; IL1RN; -.
DR   DMDM; 124312; -.
DR   EPD; P18510; -.
DR   MaxQB; P18510; -.
DR   PaxDb; P18510; -.
DR   PeptideAtlas; P18510; -.
DR   PRIDE; P18510; -.
DR   DNASU; 3557; -.
DR   Ensembl; ENST00000259206; ENSP00000259206; ENSG00000136689. [P18510-3]
DR   Ensembl; ENST00000354115; ENSP00000329072; ENSG00000136689. [P18510-2]
DR   Ensembl; ENST00000361779; ENSP00000354816; ENSG00000136689. [P18510-4]
DR   Ensembl; ENST00000409052; ENSP00000387210; ENSG00000136689. [P18510-4]
DR   Ensembl; ENST00000409930; ENSP00000387173; ENSG00000136689. [P18510-1]
DR   GeneID; 3557; -.
DR   KEGG; hsa:3557; -.
DR   UCSC; uc002tiy.3; human. [P18510-1]
DR   CTD; 3557; -.
DR   GeneCards; IL1RN; -.
DR   HGNC; HGNC:6000; IL1RN.
DR   HPA; CAB009633; -.
DR   HPA; HPA001482; -.
DR   MalaCards; IL1RN; -.
DR   MIM; 147679; gene.
DR   MIM; 612628; phenotype.
DR   MIM; 612852; phenotype.
DR   neXtProt; NX_P18510; -.
DR   Orphanet; 210115; Sterile multifocal osteomyelitis with periostitis and pustulosis.
DR   PharmGKB; PA29816; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; P18510; -.
DR   KO; K05481; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   PhylomeDB; P18510; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-HSA-446652; Interleukin-1 signaling.
DR   ChiTaRS; IL1RN; human.
DR   EvolutionaryTrace; P18510; -.
DR   GeneWiki; Interleukin_1_receptor_antagonist; -.
DR   GenomeRNAi; 3557; -.
DR   PRO; PR:P18510; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; P18510; -.
DR   CleanEx; HS_IL1RN; -.
DR   ExpressionAtlas; P18510; baseline and differential.
DR   Genevisible; P18510; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
DR   GO; GO:0005622; C:intracellular; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005152; F:interleukin-1 receptor antagonist activity; IDA:BHF-UCL.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IDA:BHF-UCL.
DR   GO; GO:0045352; F:interleukin-1 Type I receptor antagonist activity; IDA:BHF-UCL.
DR   GO; GO:0045353; F:interleukin-1 Type II receptor antagonist activity; IDA:BHF-UCL.
DR   GO; GO:0005150; F:interleukin-1, Type I receptor binding; IPI:BHF-UCL.
DR   GO; GO:0005151; F:interleukin-1, Type II receptor binding; IPI:BHF-UCL.
DR   GO; GO:0006953; P:acute-phase response; IDA:BHF-UCL.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IDA:BHF-UCL.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IDA:BHF-UCL.
DR   GO; GO:0051384; P:response to glucocorticoid; IDA:BHF-UCL.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Pharmaceutical; Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     25       {ECO:0000269|PubMed:2137200,
FT                                ECO:0000269|PubMed:2143761}.
FT   CHAIN        26    177       Interleukin-1 receptor antagonist
FT                                protein.
FT                                /FTId=PRO_0000015328.
FT   CARBOHYD    109    109       N-linked (GlcNAc...).
FT                                {ECO:0000269|PubMed:16335952,
FT                                ECO:0000269|PubMed:2137200}.
FT   DISULFID     91    141
FT   VAR_SEQ       1     34       Missing (in isoform 4).
FT                                {ECO:0000303|PubMed:9514884}.
FT                                /FTId=VSP_002651.
FT   VAR_SEQ       1     21       MEICRGLRSHLITLLLFLFHS -> MAL (in isoform
FT                                2). {ECO:0000303|PubMed:15489334,
FT                                ECO:0000303|PubMed:1827201}.
FT                                /FTId=VSP_002649.
FT   VAR_SEQ       1     21       MEICRGLRSHLITLLLFLFHS -> MALADLYEEGGGGGGE
FT                                GEDNADSK (in isoform 3).
FT                                {ECO:0000303|PubMed:14702039,
FT                                ECO:0000303|PubMed:7629520}.
FT                                /FTId=VSP_002650.
FT   VARIANT     124    124       A -> T (in dbSNP:rs45507693).
FT                                {ECO:0000269|PubMed:18987736}.
FT                                /FTId=VAR_049573.
FT   STRAND       36     42       {ECO:0000244|PDB:1ILR}.
FT   TURN         43     45       {ECO:0000244|PDB:1IRP}.
FT   STRAND       47     51       {ECO:0000244|PDB:1ILR}.
FT   STRAND       54     58       {ECO:0000244|PDB:1ILR}.
FT   HELIX        62     67       {ECO:0000244|PDB:1ILR}.
FT   STRAND       71     76       {ECO:0000244|PDB:1ILR}.
FT   TURN         77     79       {ECO:0000244|PDB:1ILR}.
FT   STRAND       80     85       {ECO:0000244|PDB:1ILR}.
FT   TURN         86     89       {ECO:0000244|PDB:1ILR}.
FT   STRAND       90     97       {ECO:0000244|PDB:1ILR}.
FT   STRAND      100    106       {ECO:0000244|PDB:1ILR}.
FT   HELIX       110    112       {ECO:0000244|PDB:1ILR}.
FT   HELIX       118    123       {ECO:0000244|PDB:1ILR}.
FT   STRAND      124    130       {ECO:0000244|PDB:1ILR}.
FT   STRAND      133    141       {ECO:0000244|PDB:1ILR}.
FT   STRAND      145    151       {ECO:0000244|PDB:1ILR}.
FT   STRAND      157    160       {ECO:0000244|PDB:1ILR}.
FT   STRAND      162    168       {ECO:0000244|PDB:1ILR}.
FT   STRAND      171    175       {ECO:0000244|PDB:1ILR}.
SQ   SEQUENCE   177 AA;  20055 MW;  D1690776A7394057 CRC64;
     MEICRGLRSH LITLLLFLFH SETICRPSGR KSSKMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGPNVNLEEK IDVVPIEPHA LFLGIHGGKM CLSCVKSGDE TRLQLEAVNI TDLSENRKQD
     KRFAFIRSDS GPTTSFESAA CPGWFLCTAM EADQPVSLTN MPDEGVMVTK FYFQEDE
//
ID   IL1RA_MOUSE             Reviewed;         178 AA.
AC   P25085; O70207;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   06-JUL-2016, entry version 134.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=Il1rn; Synonyms=Il-1ra;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 1).
RX   PubMed=1828262;
RA   Zahedi K., Seldin M.F., Rits M., Ezekowitz R.A., Whitehead A.S.;
RT   "Mouse IL-1 receptor antagonist protein. Molecular characterization,
RT   gene mapping, and expression of mRNA in vitro and in vivo.";
RL   J. Immunol. 146:4228-4233(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=1830498;
RA   Matsushime H., Roussel M.F., Matsushima K., Hishinuma A., Sherr C.J.;
RT   "Cloning and expression of murine interleukin-1 receptor antagonist in
RT   macrophages stimulated by colony-stimulating factor 1.";
RL   Blood 78:616-623(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RC   STRAIN=SWR/J;
RX   PubMed=8003626; DOI=10.1016/1043-4666(94)90001-9;
RA   Zahedi K.A., Uhlar C.M., Rits M., Prada A.E., Whitehead A.S.;
RT   "The mouse interleukin 1 receptor antagonist protein: gene structure
RT   and regulation in vitro.";
RL   Cytokine 6:1-9(1994).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC   STRAIN=FVB X DBA/1 LACJ;
RX   PubMed=9550387;
RA   Gabay C., Porter B., Fantuzzi G., Arend W.P.;
RT   "Mouse IL-1 receptor antagonist isoforms: complementary DNA cloning
RT   and protein expression of intracellular isoform and tissue
RT   distribution of secreted and intracellular IL-1 receptor antagonist in
RT   vivo.";
RL   J. Immunol. 159:5905-5913(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-178.
RX   PubMed=1828896; DOI=10.1073/pnas.88.12.5232;
RA   Eisenberg S.P., Brewer M.T., Verderber E., Heimdal P.,
RA   Brandhuber B.J., Thompson R.C.;
RT   "Interleukin 1 receptor antagonist is a member of the interleukin 1
RT   gene family: evolution of a cytokine control mechanism.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:5232-5236(1991).
RN   [6]
RP   NUCLEOTIDE SEQUENCE OF 23-178.
RX   PubMed=1834470; DOI=10.1002/eji.1830211119;
RA   Shuck M.E., Eessalu T.E., Tracey D.E., Bienkowski M.J.;
RT   "Cloning, heterologous expression and characterization of murine
RT   interleukin 1 receptor antagonist protein.";
RL   Eur. J. Immunol. 21:2775-2780(1991).
CC   -!- FUNCTION: Inhibits the activity of interleukin-1 by binding to
CC       receptor IL1R1 and preventing its association with the coreceptor
CC       IL1RAP for signaling. Has no interleukin-1 like activity.
CC   -!- SUBCELLULAR LOCATION: Isoform 1: Secreted.
CC   -!- SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P25085-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P25085-2; Sequence=VSP_002652;
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; M74294; AAA39309.1; -; mRNA.
DR   EMBL; M64404; AAA39277.1; -; mRNA.
DR   EMBL; L32838; AAA20576.1; -; Genomic_DNA.
DR   EMBL; AF001795; AAC15251.1; -; mRNA.
DR   EMBL; M57525; AAA39278.1; -; mRNA.
DR   EMBL; M63100; AAA39310.1; -; Genomic_DNA.
DR   EMBL; S64082; AAB20265.1; -; mRNA.
DR   CCDS; CCDS15736.1; -. [P25085-2]
DR   CCDS; CCDS38064.1; -. [P25085-1]
DR   PIR; A44610; A44610.
DR   RefSeq; NP_001034790.1; NM_001039701.3. [P25085-1]
DR   RefSeq; NP_112444.1; NM_031167.5. [P25085-2]
DR   UniGene; Mm.882; -.
DR   ProteinModelPortal; P25085; -.
DR   SMR; P25085; 35-177.
DR   STRING; 10090.ENSMUSP00000110126; -.
DR   ChEMBL; CHEMBL3414413; -.
DR   PaxDb; P25085; -.
DR   PeptideAtlas; P25085; -.
DR   PRIDE; P25085; -.
DR   Ensembl; ENSMUST00000114482; ENSMUSP00000110126; ENSMUSG00000026981. [P25085-1]
DR   Ensembl; ENSMUST00000114487; ENSMUSP00000110131; ENSMUSG00000026981. [P25085-2]
DR   GeneID; 16181; -.
DR   KEGG; mmu:16181; -.
DR   UCSC; uc008iox.2; mouse. [P25085-1]
DR   CTD; 3557; -.
DR   MGI; MGI:96547; Il1rn.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; P25085; -.
DR   KO; K05481; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   PhylomeDB; P25085; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-MMU-446652; Interleukin-1 signaling.
DR   PRO; PR:P25085; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; P25085; -.
DR   CleanEx; MM_IL1RN; -.
DR   ExpressionAtlas; P25085; baseline and differential.
DR   Genevisible; P25085; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; ISO:MGI.
DR   GO; GO:0005576; C:extracellular region; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0031982; C:vesicle; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005152; F:interleukin-1 receptor antagonist activity; ISO:MGI.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; ISO:MGI.
DR   GO; GO:0045352; F:interleukin-1 Type I receptor antagonist activity; ISO:MGI.
DR   GO; GO:0045353; F:interleukin-1 Type II receptor antagonist activity; ISO:MGI.
DR   GO; GO:0005150; F:interleukin-1, Type I receptor binding; ISO:MGI.
DR   GO; GO:0005151; F:interleukin-1, Type II receptor binding; ISO:MGI.
DR   GO; GO:0006953; P:acute-phase response; ISO:MGI.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IMP:MGI.
DR   GO; GO:0006629; P:lipid metabolic process; IMP:MGI.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; ISO:MGI.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; ISO:MGI.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; ISO:MGI.
DR   GO; GO:0051384; P:response to glucocorticoid; ISO:MGI.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Cytoplasm; Disulfide bond;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     26       {ECO:0000250}.
FT   CHAIN        27    178       Interleukin-1 receptor antagonist
FT                                protein.
FT                                /FTId=PRO_0000015330.
FT   CARBOHYD    110    110       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     92    142       {ECO:0000250}.
FT   VAR_SEQ       1     21       MEICWGPYSHLISLLLILLFH -> MA (in isoform
FT                                2). {ECO:0000303|PubMed:9550387}.
FT                                /FTId=VSP_002652.
SQ   SEQUENCE   178 AA;  20274 MW;  84AA002A3119C024 CRC64;
     MEICWGPYSH LISLLLILLF HSEAACRPSG KRPCKMQAFR IWDTNQKTFY LRNNQLIAGY
     LQGPNIKLEE KIDMVPIDLH SVFLGIHGGK LCLSCAKSGD DIKLQLEEVN ITDLSKNKEE
     DKRFTFIRSE KGPTTSFESA ACPGWFLCTT LEADRPVSLT NTPEEPLIVT KFYFQEDQ
//
ID   IL1RA_PIG               Reviewed;         177 AA.
AC   Q29056;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   06-JUL-2016, entry version 86.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN; Synonyms=IRAP1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Crossbred; TISSUE=Lung;
RA   Yin J., Murtaugh M.P.;
RT   "Characterization of IRAP in morphine treated pig.";
RL   Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits the activity of interleukin-1 by binding to
CC       receptor IL1R1 and preventing its association with the coreceptor
CC       IL1RAP for signaling. Has no interleukin-1 like activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; L38849; AAA99424.1; -; mRNA.
DR   RefSeq; NP_999427.1; NM_214262.1.
DR   UniGene; Ssc.16250; -.
DR   ProteinModelPortal; Q29056; -.
DR   SMR; Q29056; 27-177.
DR   PeptideAtlas; Q29056; -.
DR   GeneID; 397499; -.
DR   KEGG; ssc:397499; -.
DR   CTD; 3557; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; Q29056; -.
DR   KO; K05481; -.
DR   Proteomes; UP000008227; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     25       {ECO:0000250}.
FT   CHAIN        26    177       Interleukin-1 receptor antagonist
FT                                protein.
FT                                /FTId=PRO_0000015331.
FT   CARBOHYD    109    109       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     91    141       {ECO:0000250}.
SQ   SEQUENCE   177 AA;  20093 MW;  2114DC6119A9D5F9 CRC64;
     MEVSRYLCSY LISFLLFLFH SETACHPLGK RPCRMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGPNTKLEEK IDVVPVEPHF VFLGIHGGKL CLSCVKSGDE MKLQLDAVNI TDLRKNSEQD
     KRFTFIRSDS GPTTSFESAA CPGWFLCTAL EADQPVGLTN TPKAAVKVTK FYFQQDQ
//
ID   IL1RA_RABIT             Reviewed;         177 AA.
AC   P26890;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   20-JAN-2016, entry version 90.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN; Synonyms=IL1RA;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7509813;
RA   Cominelli F., Bortolami M., Pizarro T.T., Monsacchi L., Ferretti M.,
RA   Brewer M.T., Eisenberg S.P., Ng R.K.;
RT   "Rabbit interleukin-1 receptor antagonist. Cloning, expression,
RT   functional characterization, and regulation during intestinal
RT   inflammation.";
RL   J. Biol. Chem. 269:6962-6971(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hamada H., Mulligan R.C.;
RL   Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1427977;
RA   Goto F., Goto K., Miyata T., Ohkawara S., Takao T., Mori S.,
RA   Furukawa S., Maeda T., Iwanaga S., Shimonishi Y., Yoshinaga M.;
RT   "Interleukin-1 receptor antagonist in inflammatory exudate cells of
RT   rabbits. Production, purification and determination of primary
RT   structure.";
RL   Immunology 77:235-244(1992).
CC   -!- FUNCTION: Inhibits the activity of interleukin-1 by binding to
CC       receptor IL1R1 and preventing its association with the coreceptor
CC       IL1RAP for signaling. Has no interleukin-1 like activity.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; S68977; AAB30093.1; -; mRNA.
DR   EMBL; M57526; AAA31374.1; -; mRNA.
DR   EMBL; D21832; BAA04860.1; -; mRNA.
DR   PIR; A54377; A54377.
DR   RefSeq; NP_001076239.1; NM_001082770.1.
DR   UniGene; Ocu.1916; -.
DR   ProteinModelPortal; P26890; -.
DR   SMR; P26890; 26-177.
DR   STRING; 9986.ENSOCUP00000003600; -.
DR   GeneID; 100009558; -.
DR   KEGG; ocu:100009558; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; P26890; -.
DR   KO; K05481; -.
DR   OMA; IHGGKLC; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     25       {ECO:0000250}.
FT   CHAIN        26    177       Interleukin-1 receptor antagonist
FT                                protein.
FT                                /FTId=PRO_0000015332.
FT   CARBOHYD    109    109       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     91    141       {ECO:0000250}.
SQ   SEQUENCE   177 AA;  20214 MW;  F5BC087F097FFEAF CRC64;
     MRPSRSTRRH LISLLLFLFH SETACRPSGK RPCRMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGPNAKLEER IDVVPLEPQL LFLGIQRGKL CLSCVKSGDK MKLHLEAVNI TDLGKNKEQD
     KRFTFIRSNS GPTTTFESAS CPGWFLCTAL EADQPVSLTN TPDDSIVVTK FYFQEDQ
//
ID   IL1RA_RAT               Reviewed;         178 AA.
AC   P25086;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   06-JUL-2016, entry version 125.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=Il1rn; Synonyms=Il-1ra;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1828896; DOI=10.1073/pnas.88.12.5232;
RA   Eisenberg S.P., Brewer M.T., Verderber E., Heimdal P.,
RA   Brandhuber B.J., Thompson R.C.;
RT   "Interleukin 1 receptor antagonist is a member of the interleukin 1
RT   gene family: evolution of a cytokine control mechanism.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:5232-5236(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Inhibits the activity of interleukin-1 by binding to
CC       receptor IL1R1 and preventing its association with the coreceptor
CC       IL1RAP for signaling. Has no interleukin-1 like activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; M63101; AAA41434.1; -; Genomic_DNA.
DR   EMBL; BC070930; AAH70930.1; -; mRNA.
DR   PIR; C40956; C40956.
DR   RefSeq; NP_071530.1; NM_022194.2.
DR   UniGene; Rn.162640; -.
DR   ProteinModelPortal; P25086; -.
DR   SMR; P25086; 28-178.
DR   STRING; 10116.ENSRNOP00000007949; -.
DR   PaxDb; P25086; -.
DR   PRIDE; P25086; -.
DR   GeneID; 60582; -.
DR   KEGG; rno:60582; -.
DR   UCSC; RGD:621159; rat.
DR   CTD; 3557; -.
DR   RGD; 621159; Il1rn.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052099; -.
DR   InParanoid; P25086; -.
DR   KO; K05481; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   PhylomeDB; P25086; -.
DR   TreeFam; TF300203; -.
DR   PRO; PR:P25086; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; P25086; RN.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IDA:RGD.
DR   GO; GO:0005150; F:interleukin-1, Type I receptor binding; TAS:RGD.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEP:RGD.
DR   GO; GO:0071874; P:cellular response to norepinephrine stimulus; IEP:RGD.
DR   GO; GO:0002439; P:chronic inflammatory response to antigenic stimulus; IEP:RGD.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IEP:RGD.
DR   GO; GO:0001660; P:fever generation; IMP:RGD.
DR   GO; GO:0007613; P:memory; IMP:RGD.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
DR   GO; GO:0030336; P:negative regulation of cell migration; IDA:RGD.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   GO; GO:0014050; P:negative regulation of glutamate secretion; IMP:RGD.
DR   GO; GO:0045837; P:negative regulation of membrane potential; IDA:RGD.
DR   GO; GO:0009968; P:negative regulation of signal transduction; TAS:RGD.
DR   GO; GO:0043507; P:positive regulation of JUN kinase activity; IMP:RGD.
DR   GO; GO:0014823; P:response to activity; IEP:RGD.
DR   GO; GO:0042493; P:response to drug; IEP:RGD.
DR   GO; GO:0070555; P:response to interleukin-1; IEP:RGD.
DR   GO; GO:0070670; P:response to interleukin-4; IEP:RGD.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR   GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
DR   GO; GO:0042594; P:response to starvation; IEP:RGD.
DR   GO; GO:0019233; P:sensory perception of pain; IMP:RGD.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     26       {ECO:0000250}.
FT   CHAIN        27    178       Interleukin-1 receptor antagonist
FT                                protein.
FT                                /FTId=PRO_0000015333.
FT   CARBOHYD    110    110       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     92    142       {ECO:0000250}.
SQ   SEQUENCE   178 AA;  20282 MW;  F3A5754FB6C51B03 CRC64;
     MEICRGPYSH LISLLLILLF RSESAGHPAG KRPCKMQAFR IWDTNQKTFY LRNNQLIAGY
     LQGPNTKLEE KIDMVPIDFR NVFLGIHGGK LCLSCVKSGD DTKLQLEEVN ITDLNKNKEE
     DKRFTFIRSE TGPTTSFESL ACPGWFLCTT LEADHPVSLT NTPKEPCTVT KFYFQEDQ
//
ID   IL36A_HUMAN             Reviewed;         158 AA.
AC   Q9UHA7; B2RAD9; Q53SR7; Q5BLR4; Q7RTZ8;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   06-JUL-2016, entry version 126.
DE   RecName: Full=Interleukin-36 alpha;
DE   AltName: Full=FIL1 epsilon;
DE   AltName: Full=Interleukin-1 epsilon;
DE            Short=IL-1 epsilon;
DE   AltName: Full=Interleukin-1 family member 6;
DE            Short=IL-1F6;
DE   Flags: Precursor;
GN   Name=IL36A; Synonyms=FIL1E, IL1E, IL1F6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10625660; DOI=10.1074/jbc.275.2.1169;
RA   Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E.,
RA   Sims J.E.;
RT   "Four new members expand the IL-1 superfamily.";
RL   J. Biol. Chem. 275:1169-1175(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-12.
RC   TISSUE=Esophagus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-12; THR-63 AND
RP   ARG-134.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=11466363; DOI=10.4049/jimmunol.167.3.1440;
RA   Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S.,
RA   Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F.,
RA   Kastelein R.A.;
RT   "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function
RT   as an antagonist and agonist of NF-kappa B activation through the
RT   orphan IL-1 receptor-related protein 2.";
RL   J. Immunol. 167:1440-1446(2001).
RN   [8]
RP   FUNCTION.
RX   PubMed=14734551; DOI=10.1074/jbc.M400117200;
RA   Towne J.E., Garka K.E., Renshaw B.R., Virca G.D., Sims J.E.;
RT   "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and
RT   IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.";
RL   J. Biol. Chem. 279:13677-13688(2004).
RN   [9]
RP   NITRATION [LARGE SCALE ANALYSIS] AT TYR-96, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Pituitary adenoma;
RX   PubMed=16777052; DOI=10.1016/j.ab.2006.05.024;
RA   Zhan X., Desiderio D.M.;
RT   "Nitroproteins from a human pituitary adenoma tissue discovered with a
RT   nitrotyrosine affinity column and tandem mass spectrometry.";
RL   Anal. Biochem. 354:279-289(2006).
RN   [10]
RP   FUNCTION, AND PROCESSING.
RX   PubMed=21965679; DOI=10.1074/jbc.M111.267922;
RA   Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M.,
RA   Gabel C.A., Sims J.E.;
RT   "Interleukin-36 (IL-36) ligands require processing for full agonist
RT   (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra)
RT   activity.";
RL   J. Biol. Chem. 286:42594-42602(2011).
RN   [11]
RP   FUNCTION.
RX   PubMed=21881584; DOI=10.1038/jid.2011.234;
RA   Carrier Y., Ma H.L., Ramon H.E., Napierata L., Small C., O'Toole M.,
RA   Young D.A., Fouser L.A., Nickerson-Nutter C., Collins M.,
RA   Dunussi-Joannopoulos K., Medley Q.G.;
RT   "Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro
RT   and in vivo: implications in psoriasis pathogenesis.";
RL   J. Invest. Dermatol. 131:2428-2437(2011).
RN   [12]
RP   FUNCTION.
RX   PubMed=24829417; DOI=10.4049/jimmunol.1301481;
RA   Foster A.M., Baliwag J., Chen C.S., Guzman A.M., Stoll S.W.,
RA   Gudjonsson J.E., Ward N.L., Johnston A.;
RT   "IL-36 promotes myeloid cell infiltration, activation, and
RT   inflammatory activity in skin.";
RL   J. Immunol. 192:6053-6061(2014).
CC   -!- FUNCTION: Cytokine that binds to and signals through the
CC       IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK
CC       signaling pathways in target cells linked to a pro-inflammatory
CC       response. Part of the IL-36 signaling system that is thought to be
CC       present in epithelial barriers and to take part in local
CC       inflammatory response; similar to the IL-1 system with which it
CC       shares the coreceptor IL1RAP. Seems to be involved in skin
CC       inflammatory response by acting on keratinocytes, dendritic cells
CC       and indirectly on T-cells to drive tissue infiltration, cell
CC       maturation and cell proliferation. In cultured keratinocytes
CC       induces the expression of macrophage, T-cell, and neutrophil
CC       chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20,
CC       CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the
CC       production of proinflammatory cytokines such as TNF-alpha, IL-8
CC       and IL-6. In cultured monocytes upregulates expression of IL-1A,
CC       IL-1B and IL-6. In myeloid dendritic cells involved in cell
CC       maturation by upregulating surface expression of CD83, CD86 and
CC       HLA-DR. In monocyte-derived dendritic cells facilitates dendritic
CC       cell maturation and drives T-cell proliferation. May play a role
CC       in proinflammatory effects in the lung.
CC       {ECO:0000269|PubMed:14734551, ECO:0000269|PubMed:21881584,
CC       ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:24829417}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in immune system and fetal brain,
CC       but not in other tissues tested or in multiple hematopoietic cell
CC       lines. Predominantly expressed in skin keratinocytes but not in
CC       fibroblasts, endothelial cells or melanocytes. Increased in
CC       lesional psoriasis skin. {ECO:0000269|PubMed:11466363}.
CC   -!- INDUCTION: By Il-1 and TNF-alpha. {ECO:0000269|PubMed:11466363}.
CC   -!- PTM: N-terminal truncation leads to a dramatic enhancement of its
CC       activity (>1000-fold). {ECO:0000269|PubMed:21965679}.
CC   -!- MISCELLANEOUS: Initial experiments using non-processed full length
CC       protein found in vitro activity only in the ug range.
CC       {ECO:0000269|PubMed:14734551}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="https://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1f6/";
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DR   EMBL; AF201831; AAF25211.1; -; mRNA.
DR   EMBL; BN000002; CAD29875.1; -; Genomic_DNA.
DR   EMBL; AK314149; BAG36836.1; -; mRNA.
DR   EMBL; AY944686; AAX20113.1; -; Genomic_DNA.
DR   EMBL; AC016724; AAY14988.1; -; Genomic_DNA.
DR   EMBL; BC107042; AAI07043.1; -; mRNA.
DR   EMBL; BC107043; AAI07044.1; -; mRNA.
DR   CCDS; CCDS42734.1; -.
DR   RefSeq; NP_055255.1; NM_014440.2.
DR   RefSeq; XP_005263696.1; XM_005263639.2.
DR   RefSeq; XP_011509267.1; XM_011510965.1.
DR   UniGene; Hs.278910; -.
DR   ProteinModelPortal; Q9UHA7; -.
DR   SMR; Q9UHA7; 10-156.
DR   BioGrid; 118055; 11.
DR   STRING; 9606.ENSP00000259211; -.
DR   iPTMnet; Q9UHA7; -.
DR   PhosphoSite; Q9UHA7; -.
DR   BioMuta; IL36A; -.
DR   DMDM; 25008601; -.
DR   PaxDb; Q9UHA7; -.
DR   PeptideAtlas; Q9UHA7; -.
DR   PRIDE; Q9UHA7; -.
DR   Ensembl; ENST00000259211; ENSP00000259211; ENSG00000136694.
DR   GeneID; 27179; -.
DR   KEGG; hsa:27179; -.
DR   UCSC; uc010yxr.3; human.
DR   CTD; 27179; -.
DR   GeneCards; IL36A; -.
DR   HGNC; HGNC:15562; IL36A.
DR   HPA; HPA035615; -.
DR   MIM; 605509; gene.
DR   neXtProt; NX_Q9UHA7; -.
DR   PharmGKB; PA38389; -.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOVERGEN; HBG052100; -.
DR   InParanoid; Q9UHA7; -.
DR   KO; K05484; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   PhylomeDB; Q9UHA7; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-HSA-449147; Signaling by Interleukins.
DR   GeneWiki; IL1F6; -.
DR   GenomeRNAi; 27179; -.
DR   PRO; PR:Q9UHA7; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; Q9UHA7; -.
DR   CleanEx; HS_IL1F6; -.
DR   Genevisible; Q9UHA7; HS.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; NAS:UniProtKB.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytokine; Immunity; Inflammatory response;
KW   Innate immunity; Nitration; Polymorphism; Reference proteome;
KW   Secreted.
FT   PROPEP        1      5       {ECO:0000269|PubMed:21965679}.
FT                                /FTId=PRO_0000430545.
FT   CHAIN         6    158       Interleukin-36 alpha.
FT                                /FTId=PRO_0000153644.
FT   MOD_RES      96     96       Nitrated tyrosine.
FT                                {ECO:0000244|PubMed:16777052}.
FT   VARIANT      12     12       Q -> R (in dbSNP:rs895497).
FT                                {ECO:0000269|PubMed:14702039,
FT                                ECO:0000269|Ref.4}.
FT                                /FTId=VAR_024504.
FT   VARIANT      63     63       I -> T (in dbSNP:rs28938798).
FT                                {ECO:0000269|Ref.4}.
FT                                /FTId=VAR_025055.
FT   VARIANT     134    134       G -> R (in dbSNP:rs28947175).
FT                                {ECO:0000269|Ref.4}.
FT                                /FTId=VAR_025056.
SQ   SEQUENCE   158 AA;  17684 MW;  469AC84306B0E280 CRC64;
     MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG
     NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES
     VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF
//
ID   IL36A_MOUSE             Reviewed;         160 AA.
AC   Q9JLA2;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   06-JUL-2016, entry version 110.
DE   RecName: Full=Interleukin-36 alpha;
DE   AltName: Full=FIL1 epsilon;
DE   AltName: Full=Interleukin-1 epsilon;
DE            Short=IL-1 epsilon;
DE   AltName: Full=Interleukin-1 family member 6;
DE            Short=IL-1F6;
DE   AltName: Full=Interleukin-1 homolog 1;
DE            Short=IL-1H1;
DE   Flags: Precursor;
GN   Name=Il36a; Synonyms=Fil1e, Il1e, Il1f6, Il1h1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10744718; DOI=10.1074/jbc.275.14.10308;
RA   Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N.,
RA   Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L.,
RA   Young P.R.;
RT   "Identification and initial characterization of four novel members of
RT   the interleukin-1 family.";
RL   J. Biol. Chem. 275:10308-10314(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=11466363; DOI=10.4049/jimmunol.167.3.1440;
RA   Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S.,
RA   Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F.,
RA   Kastelein R.A.;
RT   "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function
RT   as an antagonist and agonist of NF-kappa B activation through the
RT   orphan IL-1 receptor-related protein 2.";
RL   J. Immunol. 167:1440-1446(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=20101239; DOI=10.1038/labinvest.2009.148;
RA   Ichii O., Otsuka S., Sasaki N., Yabuki A., Ohta H., Takiguchi M.,
RA   Hashimoto Y., Endoh D., Kon Y.;
RT   "Local overexpression of interleukin-1 family, member 6 relates to the
RT   development of tubulointerstitial lesions.";
RL   Lab. Invest. 90:459-475(2010).
RN   [5]
RP   FUNCTION.
RX   PubMed=21860022; DOI=10.1182/blood-2011-05-356873;
RA   Vigne S., Palmer G., Lamacchia C., Martin P., Talabot-Ayer D.,
RA   Rodriguez E., Ronchi F., Sallusto F., Dinh H., Sims J.E., Gabay C.;
RT   "IL-36R ligands are potent regulators of dendritic and T cells.";
RL   Blood 118:5813-5823(2011).
RN   [6]
RP   FUNCTION, AND PROCESSING.
RX   PubMed=21965679; DOI=10.1074/jbc.M111.267922;
RA   Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M.,
RA   Gabel C.A., Sims J.E.;
RT   "Interleukin-36 (IL-36) ligands require processing for full agonist
RT   (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra)
RT   activity.";
RL   J. Biol. Chem. 286:42594-42602(2011).
RN   [7]
RP   INDUCTION.
RX   PubMed=21881584; DOI=10.1038/jid.2011.234;
RA   Carrier Y., Ma H.L., Ramon H.E., Napierata L., Small C., O'Toole M.,
RA   Young D.A., Fouser L.A., Nickerson-Nutter C., Collins M.,
RA   Dunussi-Joannopoulos K., Medley Q.G.;
RT   "Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro
RT   and in vivo: implications in psoriasis pathogenesis.";
RL   J. Invest. Dermatol. 131:2428-2437(2011).
RN   [8]
RP   FUNCTION.
RX   PubMed=23029241; DOI=10.1371/journal.pone.0045784;
RA   Ramadas R.A., Ewart S.L., Iwakura Y., Medoff B.D., LeVine A.M.;
RT   "IL-36alpha exerts pro-inflammatory effects in the lungs of mice.";
RL   PLoS ONE 7:E45784-E45784(2012).
RN   [9]
RP   FUNCTION.
RX   PubMed=24829417; DOI=10.4049/jimmunol.1301481;
RA   Foster A.M., Baliwag J., Chen C.S., Guzman A.M., Stoll S.W.,
RA   Gudjonsson J.E., Ward N.L., Johnston A.;
RT   "IL-36 promotes myeloid cell infiltration, activation, and
RT   inflammatory activity in skin.";
RL   J. Immunol. 192:6053-6061(2014).
CC   -!- FUNCTION: Cytokine that binds to and signals through the
CC       IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK
CC       signaling pathways in target cells linked to a pro-inflammatory
CC       response. Part of the IL-36 signaling system that is thought to be
CC       present in epithelial barriers and to take part in local
CC       inflammatory response; similar to the IL-1 system with which it
CC       shares the coreceptor IL1RAP. Seems to be involved in skin
CC       inflammatory response by acting on keratinocytes, dendritic cells
CC       and indirectly on T-cells to drive tissue infiltration, cell
CC       maturation and cell proliferation. Induces the production of
CC       proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-
CC       alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs).
CC       Involved in dendritic cell maturation by stimulating the surface
CC       expression of CD80, CD86 and MHC class II. Induces the production
CC       of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and
CC       splenocytes. May play a role in proinflammatory effects in the
CC       lung: induces the expression of CXCL1 and CXCL2 in the lung, and
CC       the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2
CC       in isolated splenic CD11c(+) alveolar macrophages. May be involved
CC       in T-cell maturation by stimulating the surface expression of CD40
CC       and modestly CD80 and CD86 in splenic CD11c(+) cells. May be
CC       involved in CD4(+) T-cell proliferation. Induces NF-kappa B
CC       activation in macrophages. {ECO:0000269|PubMed:21860022,
CC       ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23029241,
CC       ECO:0000269|PubMed:24829417}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in embryonic tissue and in
CC       tissues containing epithelial cells. Elevated expression levels
CC       are detected in chronic kidney disease; expressed inepithelia from
CC       the distal convoluted tubules (DCTs) to the cortical collecting
CC       ducts (CCDs) in single nephrons (at protein level).
CC       {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:20101239}.
CC   -!- INDUCTION: By IL-22 in normal and psoriasis-like skin.
CC       {ECO:0000269|PubMed:21881584}.
CC   -!- PTM: N-terminal truncation leads to a dramatic enhancement of its
CC       activity (>1000-fold). {ECO:0000269|PubMed:21965679}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF200493; AAF69249.1; -; mRNA.
DR   EMBL; AF206697; AAG35671.1; -; mRNA.
DR   EMBL; AK004061; BAB23147.1; -; mRNA.
DR   CCDS; CCDS15734.1; -.
DR   RefSeq; NP_062323.1; NM_019450.3.
DR   UniGene; Mm.133095; -.
DR   ProteinModelPortal; Q9JLA2; -.
DR   SMR; Q9JLA2; 17-156.
DR   STRING; 10090.ENSMUSP00000028361; -.
DR   PhosphoSite; Q9JLA2; -.
DR   PaxDb; Q9JLA2; -.
DR   PRIDE; Q9JLA2; -.
DR   Ensembl; ENSMUST00000028361; ENSMUSP00000028361; ENSMUSG00000026984.
DR   GeneID; 54448; -.
DR   KEGG; mmu:54448; -.
DR   UCSC; uc008ioq.1; mouse.
DR   CTD; 54448; -.
DR   MGI; MGI:1859324; Il1f6.
DR   eggNOG; ENOG410JBMR; Eukaryota.
DR   eggNOG; ENOG41118FS; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOVERGEN; HBG052100; -.
DR   InParanoid; Q9JLA2; -.
DR   KO; K05484; -.
DR   OMA; PGWFIAV; -.
DR   OrthoDB; EOG7034JW; -.
DR   PhylomeDB; Q9JLA2; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-MMU-449147; Signaling by Interleukins.
DR   PRO; PR:Q9JLA2; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; Q9JLA2; -.
DR   CleanEx; MM_IL1F6; -.
DR   ExpressionAtlas; Q9JLA2; baseline and differential.
DR   Genevisible; Q9JLA2; MM.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; IGI:MGI.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; TAS:MGI.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0001819; P:positive regulation of cytokine production; IDA:MGI.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IGI:MGI.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytokine; Immunity; Inflammatory response;
KW   Innate immunity; Nitration; Reference proteome; Secreted.
FT   PROPEP        1      7       {ECO:0000269|PubMed:21965679}.
FT                                /FTId=PRO_0000430546.
FT   CHAIN         8    160       Interleukin-36 alpha.
FT                                /FTId=PRO_0000153645.
FT   MOD_RES      98     98       Nitrated tyrosine.
FT                                {ECO:0000250|UniProtKB:Q9UHA7}.
SQ   SEQUENCE   160 AA;  18015 MW;  AA0434D68FF62F4A CRC64;
     MNKEKELRAA SPSLRHVQDL SSRVWILQNN ILTAVPRKEQ TVPVTITLLP CQYLDTLETN
     RGDPTYMGVQ RPMSCLFCTK DGEQPVLQLG EGNIMEMYNK KEPVKASLFY HKKSGTTSTF
     ESAAFPGWFI AVCSKGSCPL ILTQELGEIF ITDFEMIVVH
//
ID   IL36B_MOUSE             Reviewed;         183 AA.
AC   Q9D6Z6; Q8R461;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   06-JUL-2016, entry version 109.
DE   RecName: Full=Interleukin-36 beta;
DE   AltName: Full=Interleukin-1 family member 8;
DE            Short=IL-1F8;
DE   Flags: Precursor;
GN   Name=Il36b; Synonyms=Fil1e, Il1f8;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Swiss Webster / NIH;
RX   PubMed=11991723; DOI=10.1006/geno.2002.6752;
RA   Taylor S.L., Renshaw B.R., Garka K.E., Smith D.E., Sims J.E.;
RT   "Genomic organization of the interleukin-1 locus.";
RL   Genomics 79:726-733(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=19717513; DOI=10.4049/jimmunol.0803301;
RA   Martin U., Scholler J., Gurgel J., Renshaw B., Sims J.E., Gabel C.A.;
RT   "Externalization of the leaderless cytokine IL-1F6 occurs in response
RT   to lipopolysaccharide/ATP activation of transduced bone marrow
RT   macrophages.";
RL   J. Immunol. 183:4021-4030(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=21860022; DOI=10.1182/blood-2011-05-356873;
RA   Vigne S., Palmer G., Lamacchia C., Martin P., Talabot-Ayer D.,
RA   Rodriguez E., Ronchi F., Sallusto F., Dinh H., Sims J.E., Gabay C.;
RT   "IL-36R ligands are potent regulators of dendritic and T cells.";
RL   Blood 118:5813-5823(2011).
RN   [5]
RP   FUNCTION, AND PROCESSING.
RX   PubMed=21965679; DOI=10.1074/jbc.M111.267922;
RA   Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M.,
RA   Gabel C.A., Sims J.E.;
RT   "Interleukin-36 (IL-36) ligands require processing for full agonist
RT   (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra)
RT   activity.";
RL   J. Biol. Chem. 286:42594-42602(2011).
CC   -!- FUNCTION: Cytokine that binds to and signals through the
CC       IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK
CC       signaling pathways in target cells linked to a pro-inflammatory
CC       response. Part of the IL-36 signaling system that is thought to be
CC       present in epithelial barriers and to take part in local
CC       inflammatory response; similar to the IL-1 system with which it
CC       shares the coreceptor IL1RAP. Stimulates production of
CC       interleukin-6 and interleukin-8 in synovial fibrobasts, articular
CC       chondrocytes and mature adipocytes. Induces expression of a number
CC       of antimicrobial peptides including beta-defensin 4 and beta-
CC       defensin 103 as well as a number of matrix metalloproteases (By
CC       similarity). Seems to be involved in skin inflammatory response by
CC       acting on keratinocytes, dendritic cells and indirectly on T-cells
CC       to drive tissue infiltration, cell maturation and cell
CC       proliferation. Induces the production of proinflammatory cytokines
CC       in bone marrow-derived dendritic cells (BMDCs), including IL-12,
CC       Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK
CC       phosphorylation in BMDCs. Involved in dendritic cell maturation by
CC       stimulating the surface expression of CD80, CD86 and MHC class II.
CC       Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1
CC       (Th1) cells, cultured CD4(+) T-cells and splenocytes.
CC       {ECO:0000250|UniProtKB:Q9NZH7, ECO:0000269|PubMed:21860022,
CC       ECO:0000269|PubMed:21965679}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19717513}.
CC       Note=Secreted upon LPS treatment followed by ATP-induced
CC       activation of P2rx7. {ECO:0000269|PubMed:19717513}.
CC   -!- PTM: N-terminal truncation leads to a dramatic enhancement of its
CC       activity (>1000-fold). {ECO:0000269|PubMed:21965679}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL67152.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AY071842; AAL67152.1; ALT_INIT; mRNA.
DR   EMBL; AK009787; BAB26505.1; -; mRNA.
DR   CCDS; CCDS38063.1; -.
DR   RefSeq; NP_081439.1; NM_027163.4.
DR   UniGene; Mm.45901; -.
DR   ProteinModelPortal; Q9D6Z6; -.
DR   SMR; Q9D6Z6; 32-177.
DR   STRING; 10090.ENSMUSP00000028363; -.
DR   PhosphoSite; Q9D6Z6; -.
DR   PaxDb; Q9D6Z6; -.
DR   PRIDE; Q9D6Z6; -.
DR   Ensembl; ENSMUST00000028363; ENSMUSP00000028363; ENSMUSG00000026985.
DR   GeneID; 69677; -.
DR   KEGG; mmu:69677; -.
DR   UCSC; uc008ion.1; mouse.
DR   CTD; 69677; -.
DR   MGI; MGI:1916927; Il1f8.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOVERGEN; HBG052100; -.
DR   InParanoid; Q9D6Z6; -.
DR   KO; K05486; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   PhylomeDB; Q9D6Z6; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-MMU-449147; Signaling by Interleukins.
DR   PRO; PR:Q9D6Z6; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; Q9D6Z6; -.
DR   CleanEx; MM_IL1F8; -.
DR   ExpressionAtlas; Q9D6Z6; baseline and differential.
DR   Genevisible; Q9D6Z6; MM.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; IGI:MGI.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0001819; P:positive regulation of cytokine production; IDA:MGI.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IGI:MGI.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IGI:MGI.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Immunity; Inflammatory response;
KW   Innate immunity; Reference proteome; Secreted.
FT   PROPEP        1     30       {ECO:0000269|PubMed:21965679}.
FT                                /FTId=PRO_0000430548.
FT   CHAIN        31    183       Interleukin-36 beta.
FT                                /FTId=PRO_0000153647.
SQ   SEQUENCE   183 AA;  20878 MW;  A3ACE339FB96F02F CRC64;
     MMAFPPQSCV HVLPPKSIQM WEPNHNTMHG SSQSPRNYRV HDSQQMVWVL TGNTLTAVPA
     SNNVKPVILS LIACRDTEFQ DVKKGNLVFL GIKNRNLCFC CVEMEGKPTL QLKEVDIMNL
     YKERKAQKAF LFYHGIEGST SVFQSVLYPG WFIATSSIER QTIILTHQRG KLVNTNFYIE
     SEK
//
ID   IL36G_HUMAN             Reviewed;         169 AA.
AC   Q9NZH8; Q56B91; Q6UVX7; Q7RTZ9;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   06-JUL-2016, entry version 128.
DE   RecName: Full=Interleukin-36 gamma;
DE   AltName: Full=IL-1-related protein 2;
DE            Short=IL-1RP2;
DE   AltName: Full=Interleukin-1 epsilon;
DE            Short=IL-1 epsilon;
DE   AltName: Full=Interleukin-1 family member 9;
DE            Short=IL-1F9;
DE   AltName: Full=Interleukin-1 homolog 1;
DE            Short=IL-1H1;
DE   Flags: Precursor;
GN   Name=IL36G; Synonyms=IL1E, IL1F9, IL1H1, IL1RP2;
GN   ORFNames=UNQ2456/PRO5737;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INDUCTION.
RC   TISSUE=Keratinocyte;
RX   PubMed=10744718; DOI=10.1074/jbc.275.14.10308;
RA   Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N.,
RA   Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L.,
RA   Young P.R.;
RT   "Identification and initial characterization of four novel members of
RT   the interleukin-1 family.";
RL   J. Biol. Chem. 275:10308-10314(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC   TISSUE=Epithelium;
RX   PubMed=11466363; DOI=10.4049/jimmunol.167.3.1440;
RA   Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S.,
RA   Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F.,
RA   Kastelein R.A.;
RT   "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function
RT   as an antagonist and agonist of NF-kappa B activation through the
RT   orphan IL-1 receptor-related protein 2.";
RL   J. Immunol. 167:1440-1446(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10860666; DOI=10.1006/geno.2000.6184;
RA   Busfield S.J., Comrack C.A., Yu G., Chickering T.W., Smutko J.S.,
RA   Zhou H., Leiby K.R., Holmgren L.M., Gearing D.P., Pan Y.;
RT   "Identification and gene organization of three novel members of the
RT   IL-1 family on human chromosome 2.";
RL   Genomics 66:213-216(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   SeattleSNPs variation discovery resource;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=20870894; DOI=10.1165/rcmb.2010-0075OC;
RA   Chustz R.T., Nagarkar D.R., Poposki J.A., Favoreto S. Jr., Avila P.C.,
RA   Schleimer R.P., Kato A.;
RT   "Regulation and function of the IL-1 family cytokine IL-1F9 in human
RT   bronchial epithelial cells.";
RL   Am. J. Respir. Cell Mol. Biol. 45:145-153(2011).
RN   [10]
RP   FUNCTION, AND PROCESSING.
RX   PubMed=21965679; DOI=10.1074/jbc.M111.267922;
RA   Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M.,
RA   Gabel C.A., Sims J.E.;
RT   "Interleukin-36 (IL-36) ligands require processing for full agonist
RT   (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra)
RT   activity.";
RL   J. Biol. Chem. 286:42594-42602(2011).
RN   [11]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=23095752; DOI=10.1074/jbc.M112.385443;
RA   Bachmann M., Scheiermann P., Hardle L., Pfeilschifter J., Muhl H.;
RT   "IL-36gamma/IL-1F9, an innate T-bet target in myeloid cells.";
RL   J. Biol. Chem. 287:41684-41696(2012).
RN   [12]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=23147407; DOI=10.1002/eji.201242711;
RA   Gresnigt M.S., Roesler B., Jacobs C.W., Becker K.L., Joosten L.A.,
RA   van der Meer J.W., Netea M.G., Dinarello C.A., van de Veerdonk F.L.;
RT   "The IL-36 receptor pathway regulates Aspergillus fumigatus-induced
RT   Th1 and Th17 responses.";
RL   Eur. J. Immunol. 43:416-426(2013).
RN   [13]
RP   FUNCTION.
RX   PubMed=24829417; DOI=10.4049/jimmunol.1301481;
RA   Foster A.M., Baliwag J., Chen C.S., Guzman A.M., Stoll S.W.,
RA   Gudjonsson J.E., Ward N.L., Johnston A.;
RT   "IL-36 promotes myeloid cell infiltration, activation, and
RT   inflammatory activity in skin.";
RL   J. Immunol. 192:6053-6061(2014).
CC   -!- FUNCTION: Cytokine that binds to and signals through the
CC       IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK
CC       signaling pathways in target cells. Part of the IL-36 signaling
CC       system that is thought to be present in epithelial barriers and to
CC       take part in local inflammatory response; similar to the IL-1
CC       system with which it shares the coreceptor IL1RAP. Seems to be
CC       involved in skin inflammatory response by acting on keratinocytes,
CC       dendritic cells and indirectly on T-cells to drive tissue
CC       infiltration, cell maturation and cell proliferation. In cultured
CC       keratinocytes induces the expression of macrophage, T-cell, and
CC       neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17,
CC       CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1;
CC       also stimulates its own expression and that of the prototypic
CC       cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin
CC       and inducible NOS. May play a role in proinflammatory responses
CC       during particular neutrophilic airway inflammation: activates
CC       mitogen-activated protein kinases and NF-kappa B in primary lung
CC       fibroblasts, and stimulates the expression of IL-8 and CXCL3 and
CC       Th17 chemokine CCL20 in lung fibroblasts. May be involved in the
CC       innate immune response to fungal pathogens, such as Aspergillus
CC       fumigatus. {ECO:0000269|PubMed:11466363,
CC       ECO:0000269|PubMed:20870894, ECO:0000269|PubMed:21965679,
CC       ECO:0000269|PubMed:23095752, ECO:0000269|PubMed:23147407,
CC       ECO:0000269|PubMed:24829417}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20870894}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9NZH8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9NZH8-2; Sequence=VSP_013002;
CC         Note=No experimental confirmation available.;
CC   -!- TISSUE SPECIFICITY: Highly expressed in tissues containing
CC       epithelial cells: skin, lung, stomach and esophagus. Expressed in
CC       bronchial epithelial. In skin is expressed only in keratinocytes
CC       but not in fibroblasts, endothelial cells or melanocytes. Up-
CC       regulated in lesional psoriasis skin. Expressed in monocyte-
CC       derived dendritic cells and M1 macrophages.
CC       {ECO:0000269|PubMed:20870894, ECO:0000269|PubMed:23095752}.
CC   -!- INDUCTION: By TNF and by IFNG/IFN-gamma in keratinocytes. By
CC       Aspergillus fumigatus conidia in peripheral blood mnonocytes;
CC       involves CLEC7A and SYK. {ECO:0000269|PubMed:10744718,
CC       ECO:0000269|PubMed:23147407}.
CC   -!- PTM: N-terminal truncation leads to a dramatic enhancement of its
CC       activity (>1000-fold). {ECO:0000269|PubMed:21965679}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="https://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1f9/";
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF200492; AAF69248.1; -; mRNA.
DR   EMBL; AF206696; AAG35670.1; -; mRNA.
DR   EMBL; BN000002; CAD29874.1; -; Genomic_DNA.
DR   EMBL; AY359111; AAQ89469.1; -; mRNA.
DR   EMBL; AY968311; AAX59035.1; -; Genomic_DNA.
DR   EMBL; AC016724; AAY14987.1; -; Genomic_DNA.
DR   EMBL; BC096721; AAH96721.1; -; mRNA.
DR   EMBL; BC098130; AAH98130.1; -; mRNA.
DR   EMBL; BC098155; AAH98155.1; -; mRNA.
DR   EMBL; BC098337; AAH98337.1; -; mRNA.
DR   CCDS; CCDS2108.1; -. [Q9NZH8-1]
DR   CCDS; CCDS62992.1; -. [Q9NZH8-2]
DR   RefSeq; NP_001265497.1; NM_001278568.1. [Q9NZH8-2]
DR   RefSeq; NP_062564.1; NM_019618.3. [Q9NZH8-1]
DR   RefSeq; XP_011509800.1; XM_011511498.1. [Q9NZH8-1]
DR   UniGene; Hs.211238; -.
DR   PDB; 4IZE; X-ray; 2.00 A; A=18-169.
DR   PDB; 4P0J; X-ray; 2.30 A; A/B=154-160.
DR   PDB; 4P0K; X-ray; 1.70 A; A=64-72, A=154-160.
DR   PDB; 4P0L; X-ray; 1.55 A; A=64-72, A=154-160.
DR   PDBsum; 4IZE; -.
DR   PDBsum; 4P0J; -.
DR   PDBsum; 4P0K; -.
DR   PDBsum; 4P0L; -.
DR   ProteinModelPortal; Q9NZH8; -.
DR   SMR; Q9NZH8; 21-169.
DR   BioGrid; 121135; 6.
DR   STRING; 9606.ENSP00000259205; -.
DR   iPTMnet; Q9NZH8; -.
DR   PhosphoSite; Q9NZH8; -.
DR   PaxDb; Q9NZH8; -.
DR   PeptideAtlas; Q9NZH8; -.
DR   PRIDE; Q9NZH8; -.
DR   Ensembl; ENST00000259205; ENSP00000259205; ENSG00000136688. [Q9NZH8-1]
DR   Ensembl; ENST00000376489; ENSP00000365672; ENSG00000136688. [Q9NZH8-2]
DR   GeneID; 56300; -.
DR   KEGG; hsa:56300; -.
DR   UCSC; uc002tio.3; human. [Q9NZH8-1]
DR   CTD; 56300; -.
DR   GeneCards; IL36G; -.
DR   HGNC; HGNC:15741; IL36G.
DR   MIM; 605542; gene.
DR   neXtProt; NX_Q9NZH8; -.
DR   PharmGKB; PA38395; -.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOVERGEN; HBG052100; -.
DR   InParanoid; Q9NZH8; -.
DR   KO; K05487; -.
DR   OMA; VITCKYP; -.
DR   PhylomeDB; Q9NZH8; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-HSA-449147; Signaling by Interleukins.
DR   SignaLink; Q9NZH8; -.
DR   GeneWiki; IL1F9; -.
DR   GenomeRNAi; 56300; -.
DR   PRO; PR:Q9NZH8; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; Q9NZH8; -.
DR   CleanEx; HS_IL1F9; -.
DR   ExpressionAtlas; Q9NZH8; baseline and differential.
DR   Genevisible; Q9NZH8; HS.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Complete proteome; Cytokine;
KW   Immunity; Inflammatory response; Innate immunity; Polymorphism;
KW   Reference proteome; Secreted.
FT   PROPEP        1     17       {ECO:0000269|PubMed:21965679}.
FT                                /FTId=PRO_0000430549.
FT   CHAIN        18    169       Interleukin-36 gamma.
FT                                /FTId=PRO_0000153648.
FT   VAR_SEQ      19     54       MCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPV -> I
FT                                (in isoform 2).
FT                                {ECO:0000303|PubMed:12975309}.
FT                                /FTId=VSP_013002.
FT   VARIANT      69     69       Q -> K (in dbSNP:rs6707930).
FT                                /FTId=VAR_024505.
FT   STRAND       23     29       {ECO:0000244|PDB:4IZE}.
FT   STRAND       33     38       {ECO:0000244|PDB:4IZE}.
FT   STRAND       41     46       {ECO:0000244|PDB:4IZE}.
FT   HELIX        47     49       {ECO:0000244|PDB:4IZE}.
FT   STRAND       55     60       {ECO:0000244|PDB:4IZE}.
FT   HELIX        64     66       {ECO:0000244|PDB:4P0L}.
FT   HELIX        69     71       {ECO:0000244|PDB:4P0L}.
FT   STRAND       73     80       {ECO:0000244|PDB:4IZE}.
FT   TURN         81     83       {ECO:0000244|PDB:4IZE}.
FT   STRAND       84     89       {ECO:0000244|PDB:4IZE}.
FT   STRAND       91     94       {ECO:0000244|PDB:4IZE}.
FT   STRAND       96    101       {ECO:0000244|PDB:4IZE}.
FT   HELIX       104    109       {ECO:0000244|PDB:4IZE}.
FT   STRAND      110    112       {ECO:0000244|PDB:4IZE}.
FT   HELIX       115    117       {ECO:0000244|PDB:4IZE}.
FT   STRAND      118    124       {ECO:0000244|PDB:4IZE}.
FT   STRAND      127    135       {ECO:0000244|PDB:4IZE}.
FT   STRAND      139    142       {ECO:0000244|PDB:4IZE}.
FT   STRAND      150    153       {ECO:0000244|PDB:4IZE}.
FT   STRAND      156    160       {ECO:0000244|PDB:4P0L}.
FT   STRAND      163    167       {ECO:0000244|PDB:4IZE}.
SQ   SEQUENCE   169 AA;  18721 MW;  F00A9243706F4154 CRC64;
     MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT
     CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY
     RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND
//
ID   IL36G_MOUSE             Reviewed;         164 AA.
AC   Q8R460; Q14BB6;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   06-JUL-2016, entry version 93.
DE   RecName: Full=Interleukin-36 gamma;
DE   AltName: Full=Interleukin-1 family member 9;
DE            Short=IL-1F9;
DE   Flags: Precursor;
GN   Name=Il36g; Synonyms=Il1f9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Swiss Webster / NIH;
RX   PubMed=11991723; DOI=10.1006/geno.2002.6752;
RA   Taylor S.L., Renshaw B.R., Garka K.E., Smith D.E., Sims J.E.;
RT   "Genomic organization of the interleukin-1 locus.";
RL   Genomics 79:726-733(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION.
RX   PubMed=21860022; DOI=10.1182/blood-2011-05-356873;
RA   Vigne S., Palmer G., Lamacchia C., Martin P., Talabot-Ayer D.,
RA   Rodriguez E., Ronchi F., Sallusto F., Dinh H., Sims J.E., Gabay C.;
RT   "IL-36R ligands are potent regulators of dendritic and T cells.";
RL   Blood 118:5813-5823(2011).
RN   [4]
RP   FUNCTION, AND PROCESSING.
RX   PubMed=21965679; DOI=10.1074/jbc.M111.267922;
RA   Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M.,
RA   Gabel C.A., Sims J.E.;
RT   "Interleukin-36 (IL-36) ligands require processing for full agonist
RT   (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra)
RT   activity.";
RL   J. Biol. Chem. 286:42594-42602(2011).
CC   -!- FUNCTION: Functions as an agonist of NF-kappa B activation through
CC       the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-
CC       36 signaling system that is thought to be present in epithelial
CC       barriers and to take part in local inflammatory response; similar
CC       to the IL-1 system with which it shares the coreceptor IL1RAP (By
CC       similarity). Seems to be involved in skin inflammatory response by
CC       acting on keratinocytes, dendritic cells and indirectly on T-cells
CC       to drive tissue infiltration, cell maturation and cell
CC       proliferation. May play a role in proinflammatory responses during
CC       particular neutrophilic airway inflammation. May be involved in
CC       the innate immune response to fungal pathogens. Induces the
CC       production of proinflammatory cytokines in bone marrow-derived
CC       dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-
CC       alpha and IL-23. Involved in dendritic cell maturation by
CC       stimulating the surface expression of CD80, CD86 and MHC class II.
CC       Induces the production of IFN-gamma, IL-4 and IL-17 by cultured
CC       CD4(+) T-cells and splenocytes. {ECO:0000250|UniProtKB:Q9NZH8,
CC       ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9NZH8}.
CC   -!- PTM: N-terminal truncation leads to a dramatic enhancement of its
CC       activity (>1000-fold). {ECO:0000269|PubMed:21965679}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AY071843; AAL67153.1; -; mRNA.
DR   EMBL; BC116227; AAI16228.1; -; mRNA.
DR   EMBL; BC116228; AAI16229.1; -; mRNA.
DR   UniGene; Mm.249379; -.
DR   ProteinModelPortal; Q8R460; -.
DR   SMR; Q8R460; 17-162.
DR   PaxDb; Q8R460; -.
DR   PRIDE; Q8R460; -.
DR   MGI; MGI:2449929; Il1f9.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   HOVERGEN; HBG052100; -.
DR   InParanoid; Q8R460; -.
DR   PRO; PR:Q8R460; -.
DR   Proteomes; UP000000589; Unplaced.
DR   Bgee; Q8R460; -.
DR   CleanEx; MM_IL1F9; -.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; IGI:MGI.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IMP:MGI.
DR   GO; GO:1901740; P:negative regulation of myoblast fusion; IMP:MGI.
DR   GO; GO:0001819; P:positive regulation of cytokine production; IDA:MGI.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IGI:MGI.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Immunity; Inflammatory response;
KW   Innate immunity; Reference proteome; Secreted.
FT   PROPEP        1     12       {ECO:0000269|PubMed:21965679}.
FT                                /FTId=PRO_0000430550.
FT   CHAIN        13    164       Interleukin-36 gamma.
FT                                /FTId=PRO_0000153649.
SQ   SEQUENCE   164 AA;  18733 MW;  A7338D475DFEADBE CRC64;
     MFSKHPFSTH ISGRETPDFG EVFDLDQQVW IFRNQALVTV PRSHRVTPVS VTILPCKYPE
     SLEQDKGIAI YLGIQNPDKC LFCKEVNGHP TLLLKEEKIL DLYHHPEPMK PFLFYHTRTG
     GTSTFESVAF PGHYIASSKT GNPIFLTSKK GEYYNINFNL DIKS
//
ID   IL37_HUMAN              Reviewed;         218 AA.
AC   Q9NZH6; B5BU97; Q56AP9; Q8TD04; Q8TD05; Q9HBF2; Q9HBF3; Q9UHA6;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   06-JUL-2016, entry version 137.
DE   RecName: Full=Interleukin-37;
DE   AltName: Full=FIL1 zeta;
DE   AltName: Full=IL-1X;
DE   AltName: Full=Interleukin-1 family member 7;
DE            Short=IL-1F7;
DE   AltName: Full=Interleukin-1 homolog 4;
DE            Short=IL-1H;
DE            Short=IL-1H4;
DE   AltName: Full=Interleukin-1 zeta;
DE            Short=IL-1 zeta;
DE   AltName: Full=Interleukin-1-related protein;
DE            Short=IL-1RP1;
DE   AltName: Full=Interleukin-23;
DE            Short=IL-37;
DE   Flags: Precursor;
GN   Name=IL37; Synonyms=FIL1Z, IL1F7, IL1H4, IL1RP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
RC   TISSUE=Fetal B-cell, Fetal colon, Fetal lung, and Fetal testis;
RX   PubMed=10744718; DOI=10.1074/jbc.275.14.10308;
RA   Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N.,
RA   Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L.,
RA   Young P.R.;
RT   "Identification and initial characterization of four novel members of
RT   the interleukin-1 family.";
RL   J. Biol. Chem. 275:10308-10314(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
RC   TISSUE=Colon carcinoma;
RA   Manoj P.P., Mantovani A., Muzio M.;
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C), PROTEIN SEQUENCE OF
RP   46-54, INTERACTION WITH IL18R1, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND VARIANTS VAL-31 AND ALA-42.
RX   PubMed=11145836; DOI=10.1006/cyto.2000.0799;
RA   Pan G., Risser P., Mao W., Baldwin D.T., Zhong A.W., Filvaroff E.,
RA   Yansura D., Lewis L., Eigenbrot C., Henzel W.J., Vandlen R.;
RT   "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-
RT   1Rrp.";
RL   Cytokine 13:1-7(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RX   PubMed=10625660; DOI=10.1074/jbc.275.2.1169;
RA   Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E.,
RA   Sims J.E.;
RT   "Four new members expand the IL-1 superfamily.";
RL   J. Biol. Chem. 275:1169-1175(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS D AND E).
RX   PubMed=11991723; DOI=10.1006/geno.2002.6752;
RA   Taylor S.L., Renshaw B.R., Garka K.E., Smith D.E., Sims J.E.;
RT   "Genomic organization of the interleukin-1 locus.";
RL   Genomics 79:726-733(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-31; ALA-42;
RP   LEU-108; TRP-152; ARG-164 AND ASN-218.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D).
RX   PubMed=19054851; DOI=10.1038/nmeth.1273;
RA   Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R.,
RA   Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y.,
RA   Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.,
RA   Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H.,
RA   Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M.,
RA   Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T.,
RA   Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A.,
RA   Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K.,
RA   Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S.,
RA   Isogai T., Imai J., Watanabe S., Nomura N.;
RT   "Human protein factory for converting the transcriptome into an in
RT   vitro-expressed proteome.";
RL   Nat. Methods 5:1011-1017(2008).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B), AND VARIANTS
RP   VAL-31 AND ALA-42.
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [11]
RP   FUNCTION, SUBCELLULAR LOCATION, MATURATION BY CASP1, AND INDUCTION.
RX   PubMed=18390730; DOI=10.4049/jimmunol.180.8.5477;
RA   Sharma S., Kulk N., Nold M.F., Graf R., Kim S.H., Reinhardt D.,
RA   Dinarello C.A., Bufler P.;
RT   "The IL-1 family member 7b translocates to the nucleus and down-
RT   regulates proinflammatory cytokines.";
RL   J. Immunol. 180:5477-5482(2008).
RN   [12]
RP   FUNCTION, INTERACTION WITH SMAD3, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND INDUCTION.
RX   PubMed=20935647; DOI=10.1038/ni.1944;
RA   Nold M.F., Nold-Petry C.A., Zepp J.A., Palmer B.E., Bufler P.,
RA   Dinarello C.A.;
RT   "IL-37 is a fundamental inhibitor of innate immunity.";
RL   Nat. Immunol. 11:1014-1022(2010).
CC   -!- FUNCTION: Suppressor of innate inflammatory and immune responses
CC       involved in curbing excessive inflammation. This function requires
CC       SMAD3. Suppresses, or reduces, proinflammatory cytokine
CC       production, including IL1A and IL6, as well as CCL12, CSF1, CSF2,
CC       CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory
CC       cytokines. Inhibits dendritic cell activation.
CC       {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}.
CC   -!- SUBUNIT: Interacts with SMAD3. Binds IL18R1, but not to IL1R1,
CC       with lower affinity than IL18, and does not seem to act as a
CC       receptor antagonist for IL18. {ECO:0000269|PubMed:11145836,
CC       ECO:0000269|PubMed:20935647}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}.
CC       Nucleus {ECO:0000269|PubMed:18390730,
CC       ECO:0000269|PubMed:20935647}. Secreted
CC       {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:18390730}.
CC       Note=Stimulation with IL1B leads to colocalization with SMAD3
CC       mostly in perinuclear regions (PubMed:20935647). Only the CASP1-
CC       cleaved mature form translocates into the nucleus upon LPS
CC       stimulation (PubMed:18390730).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=B; Synonyms=IL-1F7b, IL-HLa;
CC         IsoId=Q9NZH6-1; Sequence=Displayed;
CC         Note=The name IL-HL refers to isoform B containing polymorphisms
CC         Val-31 and Ala-42. {ECO:0000305|PubMed:11145836};
CC       Name=A;
CC         IsoId=Q9NZH6-2; Sequence=VSP_002653;
CC       Name=C; Synonyms=IL-HS;
CC         IsoId=Q9NZH6-3; Sequence=VSP_002656;
CC       Name=D; Synonyms=IL1F7d;
CC         IsoId=Q9NZH6-4; Sequence=VSP_002654;
CC       Name=E; Synonyms=IL1F7e;
CC         IsoId=Q9NZH6-5; Sequence=VSP_002655;
CC   -!- TISSUE SPECIFICITY: In general, low constitutive expression, if
CC       any, in healthy tissues; high expression in inflammatory
CC       counterparts, including in synovial tissues from individuals with
CC       active rheumatoid arthritis. Isoform A, isoform B and isoform C
CC       are expressed in testis, colon, placenta, lung and lymph node.
CC       Isoform D and isoform E were found only in testis and bone marrow.
CC       Whereas only isoform A is found in brain, only isoform B in kidney
CC       and only isoform C in heart. {ECO:0000269|PubMed:11145836,
CC       ECO:0000269|PubMed:20935647}.
CC   -!- INDUCTION: Highly induced by bacterial lipopolysaccharides (LPS)
CC       and TGFB1, more moderately by IFNG, IL18, IL1B, TNF and the
CC       dinucleotide CpG (at protein level). Constitutive expression in
CC       bone marrow macrophages is down-regulated in the presence of IL4
CC       and CSF2. Induced by phorbol myristate acetate (PMA) in different
CC       cell lines. {ECO:0000269|PubMed:18390730,
CC       ECO:0000269|PubMed:20935647}.
CC   -!- PTM: Proteolytically converted to the mature form by CASP1.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="https://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1f7/";
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DR   EMBL; AF200496; AAF69252.1; -; mRNA.
DR   EMBL; AF167368; AAG29344.1; -; mRNA.
DR   EMBL; AF251118; AAG14420.1; -; mRNA.
DR   EMBL; AF251119; AAG14421.1; -; mRNA.
DR   EMBL; AF251120; AAG14422.1; -; mRNA.
DR   EMBL; AF201832; AAF25212.1; -; mRNA.
DR   EMBL; AY071840; AAL67151.1; -; mRNA.
DR   EMBL; AY071841; AAL67154.1; -; mRNA.
DR   EMBL; AY973625; AAX59036.1; -; Genomic_DNA.
DR   EMBL; AB451333; BAG70147.1; -; mRNA.
DR   EMBL; AB451478; BAG70292.1; -; mRNA.
DR   EMBL; AC079753; AAX88889.1; -; Genomic_DNA.
DR   EMBL; CH471217; EAW73609.1; -; Genomic_DNA.
DR   EMBL; BC020637; AAH20637.1; -; mRNA.
DR   CCDS; CCDS2103.1; -. [Q9NZH6-1]
DR   CCDS; CCDS2104.1; -. [Q9NZH6-4]
DR   CCDS; CCDS2105.1; -. [Q9NZH6-5]
DR   CCDS; CCDS2106.1; -. [Q9NZH6-3]
DR   CCDS; CCDS2107.1; -. [Q9NZH6-2]
DR   RefSeq; NP_055254.2; NM_014439.3. [Q9NZH6-1]
DR   RefSeq; NP_775294.1; NM_173202.1. [Q9NZH6-4]
DR   RefSeq; NP_775295.1; NM_173203.1. [Q9NZH6-5]
DR   RefSeq; NP_775296.1; NM_173204.1. [Q9NZH6-3]
DR   RefSeq; NP_775297.1; NM_173205.1. [Q9NZH6-2]
DR   RefSeq; XP_011509265.1; XM_011510963.1. [Q9NZH6-1]
DR   RefSeq; XP_011509266.1; XM_011510964.1. [Q9NZH6-3]
DR   UniGene; Hs.166371; -.
DR   ProteinModelPortal; Q9NZH6; -.
DR   SMR; Q9NZH6; 60-192.
DR   BioGrid; 118054; 10.
DR   IntAct; Q9NZH6; 1.
DR   MINT; MINT-1208512; -.
DR   STRING; 9606.ENSP00000263326; -.
DR   BioMuta; IL37; -.
DR   DMDM; 25008593; -.
DR   PaxDb; Q9NZH6; -.
DR   PeptideAtlas; Q9NZH6; -.
DR   PRIDE; Q9NZH6; -.
DR   DNASU; 27178; -.
DR   Ensembl; ENST00000263326; ENSP00000263326; ENSG00000125571. [Q9NZH6-1]
DR   Ensembl; ENST00000311328; ENSP00000309883; ENSG00000125571. [Q9NZH6-2]
DR   Ensembl; ENST00000349806; ENSP00000263328; ENSG00000125571. [Q9NZH6-5]
DR   Ensembl; ENST00000352179; ENSP00000263327; ENSG00000125571. [Q9NZH6-4]
DR   Ensembl; ENST00000353225; ENSP00000309208; ENSG00000125571. [Q9NZH6-3]
DR   GeneID; 27178; -.
DR   KEGG; hsa:27178; -.
DR   UCSC; uc002tij.4; human. [Q9NZH6-1]
DR   CTD; 27178; -.
DR   GeneCards; IL37; -.
DR   HGNC; HGNC:15563; IL37.
DR   HPA; HPA054371; -.
DR   HPA; HPA057950; -.
DR   MIM; 605510; gene.
DR   neXtProt; NX_Q9NZH6; -.
DR   PharmGKB; PA38390; -.
DR   eggNOG; ENOG410J8RD; Eukaryota.
DR   eggNOG; ENOG41118IW; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOVERGEN; HBG052101; -.
DR   InParanoid; Q9NZH6; -.
DR   KO; K05485; -.
DR   OMA; RKHTEFS; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   PhylomeDB; Q9NZH6; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-HSA-449147; Signaling by Interleukins.
DR   GeneWiki; IL1F7; -.
DR   GenomeRNAi; 27178; -.
DR   PMAP-CutDB; Q9NZH6; -.
DR   PRO; PR:Q9NZH6; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; Q9NZH6; -.
DR   CleanEx; HS_IL1F7; -.
DR   Genevisible; Q9NZH6; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; NAS:UniProtKB.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Cytokine; Cytoplasm;
KW   Direct protein sequencing; Nucleus; Polymorphism; Reference proteome;
KW   Secreted.
FT   PROPEP        1     45       Removed in mature form.
FT                                {ECO:0000269|PubMed:11145836}.
FT                                /FTId=PRO_0000015335.
FT   CHAIN        46    218       Interleukin-37.
FT                                /FTId=PRO_0000015336.
FT   VAR_SEQ       1     49       MSFVGENSGVKMGSEDWEKDEPQCCLEDPAGSPLEPGPSLP
FT                                TMNFVHTS -> MSGCDRRETETKGKNSFKKRLRG (in
FT                                isoform A).
FT                                {ECO:0000303|PubMed:10625660}.
FT                                /FTId=VSP_002653.
FT   VAR_SEQ      28     88       Missing (in isoform E).
FT                                {ECO:0000303|PubMed:11991723}.
FT                                /FTId=VSP_002655.
FT   VAR_SEQ      28     49       DPAGSPLEPGPSLPTMNFVHTS -> G (in isoform
FT                                D). {ECO:0000303|PubMed:11991723,
FT                                ECO:0000303|PubMed:19054851}.
FT                                /FTId=VSP_002654.
FT   VAR_SEQ      49     89       SPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYIRPE
FT                                -> K (in isoform C).
FT                                {ECO:0000303|PubMed:11145836}.
FT                                /FTId=VSP_002656.
FT   VARIANT      31     31       G -> V (in dbSNP:rs3811046).
FT                                {ECO:0000269|PubMed:11145836,
FT                                ECO:0000269|PubMed:15489334,
FT                                ECO:0000269|Ref.6}.
FT                                /FTId=VAR_014260.
FT   VARIANT      42     42       T -> A (in dbSNP:rs3811047).
FT                                {ECO:0000269|PubMed:11145836,
FT                                ECO:0000269|PubMed:15489334,
FT                                ECO:0000269|Ref.6}.
FT                                /FTId=VAR_014261.
FT   VARIANT      50     50       P -> R (in dbSNP:rs2708943).
FT                                /FTId=VAR_049574.
FT   VARIANT      54     54       N -> S (in dbSNP:rs2723183).
FT                                /FTId=VAR_049575.
FT   VARIANT     108    108       P -> L (in dbSNP:rs2723187).
FT                                {ECO:0000269|Ref.6}.
FT                                /FTId=VAR_023334.
FT   VARIANT     152    152       R -> W (in dbSNP:rs28947200).
FT                                {ECO:0000269|Ref.6}.
FT                                /FTId=VAR_023335.
FT   VARIANT     164    164       W -> R (in dbSNP:rs2708947).
FT                                {ECO:0000269|Ref.6}.
FT                                /FTId=VAR_023336.
FT   VARIANT     218    218       D -> N (in dbSNP:rs2723192).
FT                                {ECO:0000269|Ref.6}.
FT                                /FTId=VAR_023337.
SQ   SEQUENCE   218 AA;  24126 MW;  96E089310D2CEA68 CRC64;
     MSFVGENSGV KMGSEDWEKD EPQCCLEDPA GSPLEPGPSL PTMNFVHTSP KVKNLNPKKF
     SIHDQDHKVL VLDSGNLIAV PDKNYIRPEI FFALASSLSS ASAEKGSPIL LGVSKGEFCL
     YCDKDKGQSH PSLQLKKEKL MKLAAQKESA RRPFIFYRAQ VGSWNMLESA AHPGWFICTS
     CNCNEPVGVT DKFENRKHIE FSFQPVCKAE MSPSEVSD
//
ID   J9NSP1_CANLF            Unreviewed;       177 AA.
AC   J9NSP1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000040581};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSCAFP00000040581};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000040581, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000040581, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000040581,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000040581}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000040581};
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000040581}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAEX03010914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03010915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_854689.3; XM_849596.4.
DR   STRING; 9615.ENSCAFP00000040581; -.
DR   PaxDb; J9NSP1; -.
DR   Ensembl; ENSCAFT00000047437; ENSCAFP00000040581; ENSCAFG00000031233.
DR   GeneID; 611873; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; J9NSP1; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002254; Chromosome 17.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   177 AA;  19881 MW;  A49A58F8E08FA433 CRC64;
     MPWRNQLDIP GFQDYSKDQS PTITGMCSLP MTRYYIIKDA DQKALYLRGD QLLVGDPNVD
     NCCAEKICIL PNRGLDRTKV PIFLGIQGGS RCLSCVETGE GPTLQLEDVN IEDLYKGGEQ
     ATRFTFFQRS SGSAFKLEAA AWPGWFLCGP AEPQQPVQLV KESEPLARTE FYFEQSR
//
ID   J9NY18_CANLF            Unreviewed;       205 AA.
AC   J9NY18;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   08-JUN-2016, entry version 30.
DE   SubName: Full=Interleukin-18 {ECO:0000313|Ensembl:ENSCAFP00000038185};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSCAFP00000038185};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000038185, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000038185, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000038185,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000038185}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000038185};
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000038185}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAEX03003491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005619540.1; XM_005619483.2.
DR   UniGene; Cfa.40; -.
DR   STRING; 9615.ENSCAFP00000038185; -.
DR   PaxDb; J9NY18; -.
DR   Ensembl; ENSCAFT00000049831; ENSCAFP00000038185; ENSCAFG00000030180.
DR   GeneID; 403796; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Reactome; R-CFA-448706; Interleukin-1 processing.
DR   Reactome; R-CFA-449147; Signaling by Interleukins.
DR   Proteomes; UP000002254; Chromosome 5.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   205 AA;  23383 MW;  7A2922BBA9284618 CRC64;
     MGRPPFLMSG IKMATNLIED NCINLVKMKF VNNTLYFKAE SDEGLESDYF GKLEPKLSII
     RNLNDQVLFV NEGNQPVFED MPDSDCTDNA PHTIFIIYMY KDSLTRGLAV TISVKYKTMS
     TLSCKNKTIS FQKMSPPDSI NDEGNDIIFF QRSVPGHDDK IQFESSLYKG HFLACKKEND
     LFKLILKDKD ENGDKSIMFT VQNKS
//
ID   J9P745_CANLF            Unreviewed;       183 AA.
AC   J9P745;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   08-JUN-2016, entry version 19.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000041480};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSCAFP00000041480};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000041480, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000041480, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000041480,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000041480}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000041480};
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000041480}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAEX03010913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCAFT00000043839; ENSCAFP00000041480; ENSCAFG00000007263.
DR   GeneTree; ENSGT00530000062899; -.
DR   OrthoDB; EOG7RRF8N; -.
DR   Reactome; R-CFA-449147; Signaling by Interleukins.
DR   Proteomes; UP000002254; Chromosome 17.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   183 AA;  20692 MW;  43B8928DDE521DBF CRC64;
     MSFLEDSGVK MESEDWERDE PHGCSEDLAR SPLEPGPSLT SISSAHSCPK VKVSYPEKFS
     IHDRDHKVLV LDCDTLRAVP FKTYIRPEMF FVLASSLSSA SKEKGSPILL AVCKGELCLC
     CEKDRRQSQP SLQLKKKKLT NLAAQKESAR QPFIFYRTKR INLTLGRSPT WISRCGSFRV
     RPL
//
ID   J9PAU1_CANLF            Unreviewed;        86 AA.
AC   J9PAU1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   08-JUN-2016, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000042918};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSCAFP00000042918};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000042918, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000042918, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000042918,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000042918}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000042918};
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000042918}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAEX03010913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; J9PAU1; -.
DR   Ensembl; ENSCAFT00000045060; ENSCAFP00000042918; ENSCAFG00000029047.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; J9PAU1; -.
DR   OMA; ICEDSGG; -.
DR   OrthoDB; EOG7034JW; -.
DR   Reactome; R-CFA-449147; Signaling by Interleukins.
DR   Proteomes; UP000002254; Chromosome 17.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   86 AA;  9655 MW;  8F4D8B9A2C71E25F CRC64;
     MCLICEDSGG QPTLLLKEEE ILALYNEMAP VEPFLFYHSK NGRTSTFESV AFPGWFIASS
     ERSHPIFLTS HQGGIYNVNF NLNINA
//
ID   K3W4N2_MOUSE            Unreviewed;       192 AA.
AC   K3W4N2;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   06-JUL-2016, entry version 28.
DE   SubName: Full=Interleukin-18 {ECO:0000313|Ensembl:ENSMUSP00000054591};
GN   Name=Il18 {ECO:0000313|Ensembl:ENSMUSP00000054591,
GN   ECO:0000313|MGI:MGI:107936};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000054591, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000054591, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000054591,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000054591}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000054591};
RG   Ensembl;
RL   Submitted (OCT-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000054591}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AC025500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K3W4N2; -.
DR   SMR; K3W4N2; 37-188.
DR   STRING; 10090.ENSMUSP00000137193; -.
DR   MaxQB; K3W4N2; -.
DR   PaxDb; K3W4N2; -.
DR   PeptideAtlas; K3W4N2; -.
DR   Ensembl; ENSMUST00000059081; ENSMUSP00000054591; ENSMUSG00000039217.
DR   MGI; MGI:107936; Il18.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   ExpressionAtlas; K3W4N2; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Proteomics identification {ECO:0000213|MaxQB:K3W4N2,
KW   ECO:0000213|PeptideAtlas:K3W4N2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   192 AA;  22150 MW;  1134C148D606D4B5 CRC64;
     MAAMSEDSCV NFKEMMFIDN TLYFIRQEAG DLESDNFGRL HCTTAVIRNI NDQVLFVDKR
     QPVFEDMTDI DQSASEPQTR LIIYMYKDSE VRGLAVTLSV KDSKMSTLSC KNKIISFEEM
     DPPENIDDIQ SDLIFFQKRV PGHNKMEFES SLYEGHFLAC QKEDDAFKLI LKKKDENGDK
     SVMFTLTNLH QS
//
ID   K7GL26_PIG              Unreviewed;       167 AA.
AC   K7GL26;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   11-MAY-2016, entry version 19.
DE   SubName: Full=Interleukin-18 {ECO:0000313|Ensembl:ENSSSCP00000028554};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSSSCP00000028554};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000028554, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000028554, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000028554};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000028554}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSSCP00000028554}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CU657951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000015962; -.
DR   PaxDb; K7GL26; -.
DR   Ensembl; ENSSSCT00000036085; ENSSSCP00000028554; ENSSSCG00000015037.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   Proteomes; UP000008227; Chromosome 9.
DR   ExpressionAtlas; K7GL26; differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   167 AA;  19135 MW;  CBDE564CAC5640FB CRC64;
     MCIVEDLESD YFGKLEPKLS IIRNLNDQVL FINQGHQAVF EDMPDSDCSD NAPQTVFIIY
     MYKDSLTRGL AVTISVQCKK MSTLSCKNKT LSFKEMSPPD NIDDEGNDII FFQRSVPGHD
     DKIQFESSLY KGYFLACKKE NDLFKLILKE KDECGDKSIM FTVQNKN
//
ID   L5KKS7_PTEAL            Unreviewed;       189 AA.
AC   L5KKS7;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-18 {ECO:0000313|EMBL:ELK11917.1};
GN   ORFNames=PAL_GLEAN10009107 {ECO:0000313|EMBL:ELK11917.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK11917.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KB030667; ELK11917.1; -; Genomic_DNA.
DR   InParanoid; L5KKS7; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   189 AA;  21827 MW;  288E50946B53D4F7 CRC64;
     MAAEPVEDNC ISFVEMKFID NTLYFVENLE SDYFGKLEPR FSIIRNLNNQ VLFIYEGNTA
     VFEDMPDSDC TDNAPQTEFI IYMYKDSLTR GLAVAICVKC NKISTLSCDN KIISFKEMNP
     PDNINEEGND IIFFKRSVPG HTDKIQFESS LYKGYFLACK KENDLFKLIL KEKDKYGDES
     VMFTVQELD
//
ID   L5KTR5_PTEAL            Unreviewed;       169 AA.
AC   L5KTR5;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   06-JUL-2016, entry version 21.
DE   SubName: Full=Interleukin-1 family member 8 {ECO:0000313|EMBL:ELK14854.1};
GN   ORFNames=PAL_GLEAN10005658 {ECO:0000313|EMBL:ELK14854.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14854.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KB030557; ELK14854.1; -; Genomic_DNA.
DR   InParanoid; L5KTR5; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   169 AA;  18819 MW;  F78455D674A4C070 CRC64;
     MGKPGLYRIR DPLQMVWVLQ GNTLVAVPAN SNVKPVTMCS VPCQHMTSGE NSHIYLGVES
     SGLCLFCMDI QGQPTLQLKE KNIMDLYEDP HVQNPFLFLR AMEGATSTFE SVAYPSWFIA
     TASVGGQPVT LTKDRGRDYN TNFYFEPMGY SRPLRVLGQG QKMSSRTSV
//
ID   L5KTV2_PTEAL            Unreviewed;       267 AA.
AC   L5KTV2;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:ELK14852.1};
GN   ORFNames=PAL_GLEAN10005656 {ECO:0000313|EMBL:ELK14852.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14852.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB030557; ELK14852.1; -; Genomic_DNA.
DR   RefSeq; XP_006909522.1; XM_006909460.1.
DR   GeneID; 102893238; -.
DR   KEGG; pale:102893238; -.
DR   CTD; 3553; -.
DR   InParanoid; L5KTV2; -.
DR   KO; K04519; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   267 AA;  30027 MW;  0230206535F42E8B CRC64;
     MAAVPELASE AMAYYSGNEN DLFFEADGPT QTKRPFHNLE LGSLGDSGIQ LQVSPQLCST
     SPGQVVSVLV ALEELRAVPT VCTQDLQEDD LRSLFFFIFE EEPLSCTWDD GYVCDAPLQS
     LSCRLRDINQ KSLVLSGPHE LQALHLNRQD ASRQVVFCMS FMPGEENDDK IPVALGIKEK
     NLYLSCVMKD RKPTLQLEMV HPEDQLKKMD KRFVFNKTDI KGKVEFESAL YPSWYISTSQ
     MEQMPVFLGS SRGGQDITDF TLEVLSH
//
ID   L5KUH7_PTEAL            Unreviewed;        84 AA.
AC   L5KUH7;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 16.
DE   SubName: Full=Interleukin-1 family member 5 {ECO:0000313|EMBL:ELK14855.1};
GN   ORFNames=PAL_GLEAN10005659 {ECO:0000313|EMBL:ELK14855.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14855.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB030557; ELK14855.1; -; Genomic_DNA.
DR   InParanoid; L5KUH7; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   84 AA;  9374 MW;  96B2CED1CF89EC7B CRC64;
     MPASLPSSWA SKGWSQCLLC GTGQEPTLKL ELVDTMQLYH SPEVAKPFTF CRWDMGVTAS
     FESAAFPGWL LCMMPEAYQP LRLT
//
ID   L5KV65_PTEAL            Unreviewed;       270 AA.
AC   L5KV65;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|EMBL:ELK14851.1};
GN   ORFNames=PAL_GLEAN10005655 {ECO:0000313|EMBL:ELK14851.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14851.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB030557; ELK14851.1; -; Genomic_DNA.
DR   RefSeq; XP_006909521.1; XM_006909459.2.
DR   GeneID; 102892998; -.
DR   KEGG; pale:102892998; -.
DR   CTD; 3552; -.
DR   InParanoid; L5KV65; -.
DR   KO; K04383; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    109       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   270 AA;  30612 MW;  6E8EC02493AD56B6 CRC64;
     MAKVPDVFED LKNCYSENEE YSSDADQLSL NQKSFYDTSY DTLHEDHGGK LRSLGTSEAS
     KMSQLTFKES VVVLAADGKV LKKRRLSFDQ FITDEDLEAI ANDTKEEPIQ PHLAPVSFQS
     SMKYSFMKVI KQQCILSDTL SQSLIRDTSG QYLMAAALND LNQAVKFDMG AYITDEDSPF
     PVTLRISETR LFLSAQNEDE PVLLKEMPET PKAIKDETNL LFLWESHGTK NYFKSVAQPK
     LFIATKQEQL VHMARGQPSI TDFQILENRP
//
ID   L5KV71_PTEAL            Unreviewed;       226 AA.
AC   L5KV71;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 19.
DE   SubName: Full=Interleukin-1 receptor antagonist protein {ECO:0000313|EMBL:ELK14856.1};
GN   ORFNames=PAL_GLEAN10005660 {ECO:0000313|EMBL:ELK14856.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14856.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
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DR   EMBL; KB030557; ELK14856.1; -; Genomic_DNA.
DR   InParanoid; L5KV71; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Receptor {ECO:0000313|EMBL:ELK14856.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   226 AA;  24794 MW;  B2784AF4BD1E6049 CRC64;
     MLSVVIRSKG GRAISSAICS SIRNADQQAL YTRGGQLLLG DPDAGDCCAE TACRPSGKRP
     SEMQAFRRMK ATLGPGPVLS TTAALLCFRI WDVNQKTFYL RNNQLVAGYL QGQNTKLEEK
     LNVVPVEPHA MLLGIHGGKL CLSCVKVGDE IRLQLEEVDI TDLSRTQEQG KRFTFIRTDS
     GTTTSFESAA CPGWFLCTAL EADQPVSLTN RPEEAVIVTK FYFQQD
//
ID   L5KVL1_PTEAL            Unreviewed;       204 AA.
AC   L5KVL1;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-1 family member 7 {ECO:0000313|EMBL:ELK14853.1};
GN   ORFNames=PAL_GLEAN10005657 {ECO:0000313|EMBL:ELK14853.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14853.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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CC   -----------------------------------------------------------------------
DR   EMBL; KB030557; ELK14853.1; -; Genomic_DNA.
DR   InParanoid; L5KVL1; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   204 AA;  22250 MW;  037C199C5D515471 CRC64;
     MSFLEESPAV RTGSEGWEGA ELQGSSGGLK VVTKDPEKFS LHDQNHKVLV LDSGTLMAVL
     NKSILPETFF VLASHLSSAC EEESPILLAV ADGELCLCCE QDKNADQPSL QLKKRKLRHL
     AIQHEADQQP FTFYRAMVGS WNTLESAMHP GWFISTSCNP GEPVRMTDEP GIKNTIEFSF
     EQVCEAKTGP AKSVGGEASP PVME
//
ID   L5LDU4_MYODS            Unreviewed;       142 AA.
AC   L5LDU4;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 15.
DE   SubName: Full=Interleukin-1 family member 10 {ECO:0000313|EMBL:ELK24494.1};
DE   Flags: Fragment;
GN   ORFNames=MDA_GLEAN10002848 {ECO:0000313|EMBL:ELK24494.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK24494.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -----------------------------------------------------------------------
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KB112867; ELK24494.1; -; Genomic_DNA.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010556};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ELK24494.1}.
SQ   SEQUENCE   142 AA;  15797 MW;  6C0AE718E10BBCCA CRC64;
     RIKDANQKAL YIRGDQLLVG DPDADNCCAE KICVLPNRGL DRTQLPIFLG IQGGRRCLAC
     VETGEGPALK LEDVSIEDLY KAGEQATRFT FFQRSLGSAF RLEAAAWPGW FLCGPAEPQQ
     PVRLAEETEP SARTEFYFEQ SQ
//
ID   L5LE86_MYODS            Unreviewed;       149 AA.
AC   L5LE86;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 17.
DE   SubName: Full=Interleukin-36 beta {ECO:0000313|EMBL:ELK24492.1};
GN   ORFNames=MDA_GLEAN10002846 {ECO:0000313|EMBL:ELK24492.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK24492.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB112867; ELK24492.1; -; Genomic_DNA.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010556};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   149 AA;  16504 MW;  5756C26F67027116 CRC64;
     MVWVLEGESL IAVPSDNNVK PATVFSVPCT DPDISNEKGS PVYLGVKEDL CLFCAEIEGR
     PTLQLKKESL MKLYKEKKAQ KSFLFLRGIE GSTSTFQSVA CPGWFIATSL QAGQPVILTN
     DRGRTYNTNF YFSSLQPELW LADSGTENL
//
ID   L5LES0_MYODS            Unreviewed;       176 AA.
AC   L5LES0;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 18.
DE   SubName: Full=Interleukin-1 receptor antagonist protein {ECO:0000313|EMBL:ELK24495.1};
GN   ORFNames=MDA_GLEAN10002849 {ECO:0000313|EMBL:ELK24495.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK24495.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
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DR   EMBL; KB112867; ELK24495.1; -; Genomic_DNA.
DR   RefSeq; XP_006771396.1; XM_006771333.2.
DR   GeneID; 102763538; -.
DR   KEGG; myd:102763538; -.
DR   CTD; 3557; -.
DR   KO; K05481; -.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010556};
KW   Receptor {ECO:0000313|EMBL:ELK24495.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    176       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003970234.
SQ   SEQUENCE   176 AA;  19922 MW;  71EA7EA5B9B5C2E0 CRC64;
     MAICRCPLSH LISLLLFLFP SETACRPSGR RPSKMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGPNTKLEEK IDVVPVEPHT VLLGIHGGKL CLACVKAGDE IRLQLEEVNI TDLSKTTEQN
     KRFTFIRSDS GPTTTFESVA CRGWFLCTAL EADQPVSLTN EPREAVRVTK FYFQQD
//
ID   L5LFU7_MYODS            Unreviewed;        70 AA.
AC   L5LFU7;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 18.
DE   SubName: Full=Interleukin-36 receptor antagonist protein {ECO:0000313|EMBL:ELK24493.1};
GN   ORFNames=MDA_GLEAN10002847 {ECO:0000313|EMBL:ELK24493.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK24493.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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CC   -----------------------------------------------------------------------
DR   EMBL; KB112867; ELK24493.1; -; Genomic_DNA.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010556};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Receptor {ECO:0000313|EMBL:ELK24493.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   70 AA;  8160 MW;  352F8805EA11C5F7 CRC64;
     MELYRSPKDS RGFTFYRRDT GLTSRFESAA FPGWFLCTVP EADQPLRLSQ LPGDASWDPP
     IMDFYFQQCD
//
ID   L5LRS4_MYODS            Unreviewed;       397 AA.
AC   L5LRS4;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 13.
DE   SubName: Full=Interleukin-37 {ECO:0000313|EMBL:ELK28786.1};
GN   ORFNames=MDA_GLEAN10001597 {ECO:0000313|EMBL:ELK28786.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK28786.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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CC   -----------------------------------------------------------------------
DR   EMBL; KB108788; ELK28786.1; -; Genomic_DNA.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010556};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   397 AA;  42508 MW;  238D7740BC0D8305 CRC64;
     MSFQEQSAEA QVDSADGEGA GAQGSTEDPA QDALEPSLSP SSLSLAAAET FYVLASTLSS
     EGNKGNPVFL AVSGGKLCLY CEMDKKKGRP TLQLKKKDIS QLHASNTTDL KGFTFYRKKM
     SKCWNTLESA AHQGWFISTC HVNEHVRMTD KPGTQELVDF AFVPVSSAHT GPSEMMTTSS
     PPSDLPYALH RKPKDKADTP LSVGYPGTFS IRDPQQMVWV LEGESLIAVP SDNNVKPATV
     FSVPCTDPDI SSEKGSPIYL GVKEDLCLFC AEIEGRPTLQ LKSHQVLAPA ASTGPAHTCY
     RHLVLAPITW LCQQVRVVAA GRITPQGIST SPCFLEAISI GSCFSYPLLV MAPLTPTAGT
     GAATRTHCQH QPCFHMQLVP EPPHTPIAGT CAGPNHP
//
ID   L5LRV7_MYODS            Unreviewed;       269 AA.
AC   L5LRV7;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 19.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|EMBL:ELK28787.1};
GN   ORFNames=MDA_GLEAN10001598 {ECO:0000313|EMBL:ELK28787.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK28787.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   EMBL; KB108788; ELK28787.1; -; Genomic_DNA.
DR   RefSeq; XP_006765735.1; XM_006765672.2.
DR   GeneID; 102770100; -.
DR   KEGG; myd:102770100; -.
DR   CTD; 3552; -.
DR   KO; K04383; -.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010556};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    108       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   269 AA;  30761 MW;  4D2A3017D4363674 CRC64;
     MAQVPDLFED LKSCYSENEE YSSEIDQLSL NQKSFYDASY DPLPKNCMGR FLSLSTSETS
     ETSQLTYKES VVVVAANGKI LKKRRLSFNQ FITDDDLETI ANDPEEEILQ PTSAPYSFQG
     NVKYPFMRVI KRHFILNDDL HQSIIRDASG RFLMAAALNN MDQAVKFDMG AYKSDDLKHP
     VTLRISDTRL FLSAQNEGES VLLKELPETP KIITDETNLL FFWETQGNKD YFESVAHPKL
     FIATKQEYQV HMASGHPSII DLQILENYP
//
ID   L5LRY7_MYODS            Unreviewed;       135 AA.
AC   L5LRY7;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   11-MAY-2016, entry version 16.
DE   SubName: Full=Interleukin-36 beta {ECO:0000313|EMBL:ELK28785.1};
GN   ORFNames=MDA_GLEAN10001595 {ECO:0000313|EMBL:ELK28785.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK28785.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KB108788; ELK28785.1; -; Genomic_DNA.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010556};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   135 AA;  14969 MW;  7C93FFE8E1BC300C CRC64;
     MVWELEGESL IAVPSDNNVK HATVFSVPCT DPDISSEKGS PIYLGVKEDL CLFCAEIEGR
     PTLQLKKESL MKLYEEKKAQ KSFLFLRGIE GSTSTFQSVA CPGWFIATSS QAGQPVTLTN
     DRGRTYNTNF YFSSL
//
ID   L9JLV7_TUPCH            Unreviewed;       365 AA.
AC   L9JLV7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-MAY-2016, entry version 13.
DE   SubName: Full=Interleukin-37 {ECO:0000313|EMBL:ELW51476.1};
GN   ORFNames=TREES_T100021686 {ECO:0000313|EMBL:ELW51476.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW51476.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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CC   -----------------------------------------------------------------------
DR   EMBL; KB320971; ELW51476.1; -; Genomic_DNA.
DR   InParanoid; L9JLV7; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 2.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   365 AA;  41008 MW;  F7DEF8B4E9EBA9B4 CRC64;
     MSFVGENSGV KVDSKGWGKD DPQCCSEDMD GNSLEQDSSF SSINYSHSGA KLKPKGPEKF
     IISDWFQNVL VLDDQILRAV PRKTNIHPAI FSVLASHSIQ ASEKKGNPIF LAVSEGKLCL
     CCDYDKKQKH PTLQLKKQNL TSLSTKKEPE CRPFIFYRKK VGSRNTLESA AHPKWFICTS
     YTPREPVSVT DKVGESKPIE FSFDPPPKAE MNPKVDRPRV GIISDLSHQV WILQNQSLVA
     VPRSGNVDQV TIIFITCKYP ETLEQGKGNP IYLGIRDPEM CLCCEDVGGQ HTLQLKKQKI
     MDLYNQDEPV KPFLFYHLKT GRTSTFESVA FPGWFIASSG RDQPLFLTSK QGNSHNIDFD
     LDITD
//
ID   L9JLW6_TUPCH            Unreviewed;       155 AA.
AC   L9JLW6;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Interleukin-36 receptor antagonist protein {ECO:0000313|EMBL:ELW51481.1};
GN   ORFNames=TREES_T100021689 {ECO:0000313|EMBL:ELW51481.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW51481.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB320971; ELW51481.1; -; Genomic_DNA.
DR   RefSeq; XP_006156726.1; XM_006156664.1.
DR   GeneID; 102477774; -.
DR   KEGG; tup:102477774; -.
DR   CTD; 26525; -.
DR   InParanoid; L9JLW6; -.
DR   KO; K05483; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Receptor {ECO:0000313|EMBL:ELW51481.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   155 AA;  17160 MW;  0E7109A8F117FCEF CRC64;
     MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWI DAKFSPVILG
     VQGGSQCLSC GTEKEPTLRL EPVNIMELYQ GGKESKNFTF YRWDKGLTSS FESATNPGWF
     LCTAHEADQP VGLTRIPEDA GWDAPITDFY FQQCD
//
ID   L9JLW9_TUPCH            Unreviewed;       266 AA.
AC   L9JLW9;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-MAY-2016, entry version 21.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:ELW51475.1};
GN   ORFNames=TREES_T100021655 {ECO:0000313|EMBL:ELW51475.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW51475.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB320971; ELW51475.1; -; Genomic_DNA.
DR   RefSeq; XP_006156719.1; XM_006156657.2.
DR   GeneID; 102475138; -.
DR   KEGG; tup:102475138; -.
DR   CTD; 3553; -.
DR   InParanoid; L9JLW9; -.
DR   KO; K04519; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    103       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   266 AA;  30500 MW;  B0C38E45A2E2B4F3 CRC64;
     MAVVPELANE MMDYYSAEED YLLFEADGPK QTKSFYQDVD FCSPDKGIQL QISHQSYDKS
     FKKFVSVIVA VEKLKKTLVP CPQDFQDIDL SILFSLIFDE KPISSGEWDD LLECDAHVKS
     INCKLEDSEE KSLVLSDPQV LKAIHLQKHN QHQEVVITMS IVQGDENSEK TPVVLSLKGK
     NLYLSCIMQD NKPTLQLEKL DPKHYPRKKM EKRFVFNRTE IGTKLEFESA LFPTWYISTT
     RAENMPVYLG KNDGSQDLTD FTKLPA
//
ID   L9JLY3_TUPCH            Unreviewed;       189 AA.
AC   L9JLY3;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-36 alpha {ECO:0000313|EMBL:ELW51480.1};
GN   ORFNames=TREES_T100021688 {ECO:0000313|EMBL:ELW51480.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW51480.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB320971; ELW51480.1; -; Genomic_DNA.
DR   InParanoid; L9JLY3; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   189 AA;  21383 MW;  C9CFC7BEDB4210C8 CRC64;
     MPRNGKDAQE STKNWRRGCS VPSFLPICIF TFCIELARIQ PLVGDIQDSS HRVWVLQGKT
     LTAVPRKQHT VPVTITLIPC KNLETLEKDR GNPIYLGLKE PELCLSCRKV GEQPMLQLME
     QNIMDLHNQS NPVLPFLFYH NRSGSISTFE SVAFPRWFLS AGSKGECPLI LTQELGTINT
     TEFQLTILK
//
ID   L9JMA3_TUPCH            Unreviewed;       143 AA.
AC   L9JMA3;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-MAY-2016, entry version 18.
DE   SubName: Full=Interleukin-1 receptor antagonist protein {ECO:0000313|EMBL:ELW51483.1};
GN   ORFNames=TREES_T100021691 {ECO:0000313|EMBL:ELW51483.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW51483.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
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DR   EMBL; KB320971; ELW51483.1; -; Genomic_DNA.
DR   RefSeq; XP_006156731.1; XM_006156669.2.
DR   GeneID; 102478649; -.
DR   CTD; 3557; -.
DR   InParanoid; L9JMA3; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Receptor {ECO:0000313|EMBL:ELW51483.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   143 AA;  16291 MW;  E9CE998F2070BECB CRC64;
     MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN TRLEEKIDVV SIEPHTVFLG IHGGKLCLSC
     VKSGDDIRLQ LEEVNITDLS KNKEQNDRFT FLRSDSGPTT SFESAACRGW FLCTALEADR
     PVSLTNTPEK PIMVTKFYFQ QDP
//
ID   L9JMH4_TUPCH            Unreviewed;       266 AA.
AC   L9JMH4;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-MAY-2016, entry version 19.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|EMBL:ELW51474.1};
GN   ORFNames=TREES_T100021656 {ECO:0000313|EMBL:ELW51474.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW51474.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB320971; ELW51474.1; -; Genomic_DNA.
DR   RefSeq; XP_006156720.1; XM_006156658.1.
DR   GeneID; 102475560; -.
DR   KEGG; tup:102475560; -.
DR   CTD; 3552; -.
DR   InParanoid; L9JMH4; -.
DR   KO; K04383; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    106       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   266 AA;  29943 MW;  5D50BE267F89D381 CRC64;
     MAKVPDLFED LKNCYSENAE YSSSIEHLSL NQKSFYDSSY DPLQEDCMGQ FMTLNTSETS
     KISTLTFKES VVVTVNGKIL KKRRLSFSQP ITDEDLKVIA SDPVEELVVP RSASSLSRSN
     VKYTFMRIIK REFTLNDALH QAVTKSDQFL KAAALTNPNH AVKFDMGAYK SADDSNLPVT
     LRISKTRLYV SAQNEGEPVL LQEMSEIPKT ITDGQINLLF FWESNGTKSY FKSVANPELL
     IATKQNDIVH MARGQPSITD FDILEN
//
ID   L9JMJ2_TUPCH            Unreviewed;       205 AA.
AC   L9JMJ2;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-36 beta {ECO:0000313|EMBL:ELW51479.1};
GN   ORFNames=TREES_T100021653 {ECO:0000313|EMBL:ELW51479.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW51479.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB320971; ELW51479.1; -; Genomic_DNA.
DR   InParanoid; L9JMJ2; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   205 AA;  23418 MW;  2E5E267AEAE49312 CRC64;
     MATPQLRRLP SYYHIRDTQQ MVWVLNENSL IAAPLTNNIK PDSSKTIMAT PQLRRLPSYY
     HIRDTQQMVW VLNENSLIAA PLTNNIKPVT IEITECKHAE FYDEGKGNLV YMGIKGKGLC
     LFCTETQGKP TLQLEAETVM SLYDKDNSEK PFLFYHNKEG STSVFQSVSY PGWFIANSST
     PREPVILTQE RGTNNNTNFY LEAED
//
ID   L9JQQ2_TUPCH            Unreviewed;       138 AA.
AC   L9JQQ2;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-MAY-2016, entry version 18.
DE   SubName: Full=Interleukin-36 beta {ECO:0000313|EMBL:ELW51477.1};
GN   ORFNames=TREES_T100021654 {ECO:0000313|EMBL:ELW51477.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW51477.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB320971; ELW51477.1; -; Genomic_DNA.
DR   InParanoid; L9JQQ2; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    138       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003999733.
SQ   SEQUENCE   138 AA;  15629 MW;  EF35F276FB739B96 CRC64;
     MVWVLNGLSL TAAPLTNSVK PVALDIIDCT DEEFRDEKKG NLVYLAIKDK NICLFCADVQ
     GKPTLQLKEK NIMDLYRQNK AEKPFLFFRN KEGSTSVFQS VAYPGWFIAT SSTPKEPVIL
     TQERGTNKKT NFYLDSDN
//
ID   L9JQR4_TUPCH            Unreviewed;       140 AA.
AC   L9JQR4;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-1 family member 10 {ECO:0000313|EMBL:ELW51482.1};
GN   ORFNames=TREES_T100021690 {ECO:0000313|EMBL:ELW51482.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW51482.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB320971; ELW51482.1; -; Genomic_DNA.
DR   InParanoid; L9JQR4; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   140 AA;  15003 MW;  9FAC1C72B97E603E CRC64;
     MALVQLFCPA RIKDANQKAL YARDGQLLVG GSEADNCSAE KICILPNRGL DRSKVPILLG
     IQGGSCCLAC VETRDGPTVQ LESTTLPPQD VNIEDLYKGG EQATRFTFFQ SSVGSTFRLE
     AAAWPGWVLC GQKKPAGQGE
//
ID   L9KNC4_TUPCH            Unreviewed;       121 AA.
AC   L9KNC4;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-MAY-2016, entry version 13.
DE   SubName: Full=Interleukin-18 {ECO:0000313|EMBL:ELW64253.1};
GN   ORFNames=TREES_T100013195 {ECO:0000313|EMBL:ELW64253.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW64253.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB320750; ELW64253.1; -; Genomic_DNA.
DR   InParanoid; L9KNC4; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   121 AA;  13731 MW;  0BAB5FD6611F49EF CRC64;
     MPDTDSNKSQ VKFKIFMYRD SLIRGLAVAI SVEYNEISTL SCENKTLSFK NISPPDNISD
     TKSDIIFFQS KVPGHNKMQF ESSSYEGHFL ACVKENDLFK LTLKKKGDCK DKSVMFTVEA
     N
//
ID   M3WBP0_FELCA            Unreviewed;       156 AA.
AC   M3WBP0;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   08-JUN-2016, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000008875};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSFCAP00000008875};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000008875, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000008875, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008875,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of SAA cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000008875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008875};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000008875}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008875};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000008875}.
CC   -----------------------------------------------------------------------
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DR   EMBL; AANG02054288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFCAT00000009571; ENSFCAP00000008875; ENSFCAG00000009571.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; M3WBP0; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   Proteomes; UP000011712; Chromosome A3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   156 AA;  17240 MW;  041A7B061977CA8D CRC64;
     KMVLSGALCF RMKDAELKVL YLHDNQLLAG RLHAGNIIQG EEISVVPNRS LDAKLSPVIL
     GVQGGSQCLS CGTGQEPTLK LEPVNIMELY LGAKESKSFT FYRRDTGLTS SFESAAYPGW
     FLCTVPEADQ PLRLTQLSED ASWDSPITDF YFQQCD
//
ID   M3WBP3_FELCA            Unreviewed;       152 AA.
AC   M3WBP3;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   08-JUN-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000008878};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSFCAP00000008878};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000008878, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000008878, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008878,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of SAA cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000008878}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008878};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000008878}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008878};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000008878}.
CC   -----------------------------------------------------------------------
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AANG02054288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003984291.1; XM_003984242.3.
DR   STRING; 9685.ENSFCAP00000008878; -.
DR   Ensembl; ENSFCAT00000009574; ENSFCAP00000008878; ENSFCAG00000009572.
DR   GeneID; 101096973; -.
DR   KEGG; fca:101096973; -.
DR   CTD; 84639; -.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; M3WBP3; -.
DR   KO; K05488; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   Proteomes; UP000011712; Chromosome A3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  16950 MW;  50CCB3558B400D6E CRC64;
     MCSLPMARYY TIKDADQKAL YLRGDQLLVG DPSADDCCAE KICILPNRGL DRTKVPIFLG
     LQGGSRCLAC VETEEGPSLQ LEDVNIEDLY KGGEQATRFT FFQRSLGSAF RLEAAAWPGW
     FLCGPAEPQQ PVRLAKESEP LACTEFYFEQ SR
//
ID   M3WBP6_FELCA            Unreviewed;       177 AA.
AC   M3WBP6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000008881};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSFCAP00000008881};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000008881, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000008881, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008881,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of SAA cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000008881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008881};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000008881}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008881};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000008881}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AANG02054289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003984290.1; XM_003984241.3.
DR   STRING; 9685.ENSFCAP00000008881; -.
DR   Ensembl; ENSFCAT00000009578; ENSFCAP00000008881; ENSFCAG00000009575.
DR   GeneID; 101096719; -.
DR   KEGG; fca:101096719; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; M3WBP6; -.
DR   KO; K05481; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   Proteomes; UP000011712; Chromosome A3.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    177       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004041845.
SQ   SEQUENCE   177 AA;  20183 MW;  086AB76E329F6ECA CRC64;
     MEIRRCPPSY LISFLLFSFY PETACHPLGK RPCRMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGPSTKLEEK LNVVPIESHA MFLGIHGGKL CLACVKSGDE TRLQLEAVNI TDLSKNKEQD
     KRFTFIRSDS GPTTSFESAA CPGWFLCTAL EADRPVSLTN TPEEAMLVTK FYFQMER
//
ID   M3WFY6_FELCA            Unreviewed;       153 AA.
AC   M3WFY6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   08-JUN-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000011032};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSFCAP00000011032};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011032, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000011032, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011032,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of SAA cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000011032}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011032};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000011032}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011032};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000011032}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AANG02054286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFCAT00000011893; ENSFCAP00000011032; ENSFCAG00000011890.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; M3WFY6; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   Proteomes; UP000011712; Chromosome A3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   153 AA;  17078 MW;  5B7BF3A376426789 CRC64;
     TVVNKPQTGE VSDLNQQVWI LQDQTIVTVP RTDSVTPVTV TVVPCKYPEY LEQGRGIPIY
     MGIENPEMCL SCEDIGGQPT LQLKEEEILD LYNEVAPVEP FLFYHSKDGR TSTFESVAFP
     GWFIASSEIR HPLFLTSDLG GKNNVNFNLS INA
//
ID   M3WPS5_FELCA            Unreviewed;       148 AA.
AC   M3WPS5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   08-JUN-2016, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000016345};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSFCAP00000016345};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000016345, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000016345, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016345,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of SAA cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000016345}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016345};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000016345}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016345};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000016345}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AANG02054286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFCAT00000018675; ENSFCAP00000016345; ENSFCAG00000019297.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; M3WPS5; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   Proteomes; UP000011712; Chromosome A3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   148 AA;  16798 MW;  6ED15D5FFABA80F7 CRC64;
     RIFGVHDSLQ MVWVLNGNSL ITTPFNNNVS PVSLDLMTCM DKEFHDAGKG NPVYLGIKNN
     HLCLFCGEIQ GQPTLQLKEK NIMDVHNKKK AQKPFLFFHN KEGSTSTFQS VSYPDWFIAT
     SKTAGQPVIL TKERGKDYIT NFYLEPQD
//
ID   M3WT43_FELCA            Unreviewed;       192 AA.
AC   M3WT43;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Interleukin-18 {ECO:0000313|Ensembl:ENSFCAP00000017529};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSFCAP00000017529};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017529, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000017529, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017529,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of SAA cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000017529}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017529};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000017529}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017529};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000017529}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AANG02199792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006936646.1; XM_006936584.1.
DR   STRING; 9685.ENSFCAP00000017529; -.
DR   Ensembl; ENSFCAT00000032604; ENSFCAP00000017529; ENSFCAG00000029199.
DR   GeneID; 493688; -.
DR   CTD; 3606; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   Proteomes; UP000011712; Chromosome D1.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   192 AA;  22098 MW;  5419CEB7B7B84A3D CRC64;
     MTAIPVDDCI NFVGMKFIDN TLYFVADSDE NLETDYFGKL EHKLSILRNL NDQVLFINQG
     DQPVFEDMPD SDCTDNAPRT EFIIYMYKDS LTRGLAVTIS VNYKTMSTLS CENKIISFKE
     MSPPESINDE GNDIIFFQRS VPGHDDKIQF ESSLYKGYFL ACEKEKDLFK LILKKKDENG
     DKSIMFTVQN KN
//
ID   M3XGS4_LATCH            Unreviewed;       200 AA.
AC   M3XGS4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000021930};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSLACP00000021930};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000021930, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000021930}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000021930}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLACP00000021930}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AFYH01006931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01006932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01006933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01006934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01006935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01006936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01006937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005987298.1; XM_005987236.2.
DR   STRING; 7897.ENSLACP00000021930; -.
DR   Ensembl; ENSLACT00000025435; ENSLACP00000021930; ENSLACG00000022302.
DR   GeneID; 102356354; -.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; M3XGS4; -.
DR   OMA; CDKESSH; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   200 AA;  23195 MW;  5EE6E397D1A23BA8 CRC64;
     MSSETSTDSQ ATETEMWLAF FNDDGLWFEE VSTDYESDAW KKYTSADVKI INACNQILVA
     QLQREDELGL VFHDVPSRNI RRDGMEFTFQ YYKETKPKRG IPLVFLVKME NKTFYMYCDK
     ESSHTVLRFK EGNAPADISD NENSLIFYQV AASTGSHKTM FKAAYEEGLY LAFEKQDNLN
     KLVLKRVNDE VDETATFRCQ
//
ID   M3XX49_MUSPF            Unreviewed;       193 AA.
AC   M3XX49;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 19.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000003649};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSMPUP00000003649};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000003649, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000003649}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000003649};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000003649}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000003649}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEYP01026651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9669.ENSMPUP00000003649; -.
DR   Ensembl; ENSMPUT00000003716; ENSMPUP00000003649; ENSMPUG00000003678.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; M3XX49; -.
DR   OMA; PVFEDMP; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22019 MW;  55571F2FF5BEC8A8 CRC64;
     MATNPVEDNC INFVGMKFID NTLYFVAEND DNLESDYFGK LEPRLSIIRN LNDQVLFVNE
     GNQPVFEDMP DSDCTENASH TVFIINMYKD SLTRGLAVTI SVMCNRMSTL SCKNKTISFK
     EMRPPDSISD EGNDIIFFQR SVPGHDDKIQ FESSLYQGHF LACKREKELF KLILKEKDGS
     GDKSVMFTVQ NPK
//
ID   M3YDQ8_MUSPF            Unreviewed;       158 AA.
AC   M3YDQ8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   08-JUN-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000009465};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSMPUP00000009465};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000009465, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000009465}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000009465};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000009465}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000009465}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   EMBL; AEYP01011086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004742458.1; XM_004742401.2.
DR   STRING; 9669.ENSMPUP00000009465; -.
DR   Ensembl; ENSMPUT00000009621; ENSMPUP00000009465; ENSMPUG00000009542.
DR   GeneID; 101678718; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; M3YDQ8; -.
DR   OMA; IHGGKLC; -.
DR   OrthoDB; EOG7X6M1M; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   158 AA;  17823 MW;  F014B26B4B33B7E4 CRC64;
     MAAEIACHPS GKRPCRMQVF RIWDINQKTF YLRNNQLVAG YLQGSNTKLE EKLDVVPIEP
     HTVFLGIHGG KLCLSCVKSG DETRLQLEAV NITDLSKSKD QDKRFTFILS DSGPTTRFES
     AACPGWFLCT ALEADRPVSF TNTPEEARTV TKFYFQKD
//
ID   M3YDR5_MUSPF            Unreviewed;       152 AA.
AC   M3YDR5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 16.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000009472};
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSMPUP00000009472};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000009472, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000009472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000009472};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000009472}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000009472}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEYP01011088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9669.ENSMPUP00000009472; -.
DR   Ensembl; ENSMPUT00000009628; ENSMPUP00000009472; ENSMPUG00000009549.
DR   eggNOG; ENOG410IWY5; Eukaryota.
DR   eggNOG; ENOG41118N6; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; M3YDR5; -.
DR   OMA; AAWPGWF; -.
DR   OrthoDB; EOG747PKM; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   152 AA;  17026 MW;  4A07DC8D405FA798 CRC64;
     MCSLPMARYY IIKDADQKAL YLRGDQLLVG DPSADNCCAE KICILPNRGL DRTKVPIFLG
     IQGGRRCLAC VETGEGPTLQ LEDVNIEDLY KGGEEATRFT FFQRSLGSAF RLEAAAWPGW
     FLCGPAEPQQ PVQLVKESEP LARTEFYFEQ SR
//
ID   M3YDT8_MUSPF            Unreviewed;       156 AA.
AC   M3YDT8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000009495};
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSMPUP00000009495};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000009495, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000009495}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000009495};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000009495}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000009495}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEYP01011088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMPUT00000009651; ENSMPUP00000009495; ENSMPUG00000009572.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; M3YDT8; -.
DR   OMA; MKDSALK; -.
DR   OrthoDB; EOG7QG45K; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   156 AA;  17066 MW;  B52FEE0781DDE9D6 CRC64;
     KMVLSGALCF RMKDAALKVL YLHDNQLLAG GLHAGKVIKG EEISVVPNRS LDAKLSPVIL
     GVQGGSQCLS CGTGQEPTLK LEPVNIMELY LGANESKSFT FYRRDTGLTS RFESAAYPGW
     FLCTLPEADQ PLTLTQLSED ASWGNPITDF YFQQCD
//
ID   M3YDW1_MUSPF            Unreviewed;       183 AA.
AC   M3YDW1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000009518};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSMPUP00000009518};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000009518, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000009518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000009518};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000009518}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000009518}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEYP01011089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9669.ENSMPUP00000009518; -.
DR   Ensembl; ENSMPUT00000009674; ENSMPUP00000009518; ENSMPUG00000009595.
DR   eggNOG; ENOG410JCFD; Eukaryota.
DR   eggNOG; ENOG41118F0; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; M3YDW1; -.
DR   OMA; FQSVSYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   183 AA;  20893 MW;  1EC0A30AF5188BA9 CRC64;
     VNLKPAWKFL HPASPKTIEY KGPYHLISYR LAEFPRTFGV HDSQQMVWIL RENSLIATPF
     SSNVKPVSLD LITCTDKEFH DAGKGNPVYL GIKGNHLCLF CAEIQGQPTL QLKEKKIMDM
     SKEKKAQKPF LFFHSREGST STFQSVSYPD WFIATSTMAG QPVILTKERG KNYTTNFYLE
     PED
//
ID   M3YDX6_MUSPF            Unreviewed;       156 AA.
AC   M3YDX6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 17.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000009533};
GN   Name=IL36G {ECO:0000313|Ensembl:ENSMPUP00000009533};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000009533, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000009533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000009533};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000009533}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000009533}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEYP01011091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01011092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01011093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMPUT00000009689; ENSMPUP00000009533; ENSMPUG00000009609.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; M3YDX6; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   156 AA;  17478 MW;  C390A441C5141AA2 CRC64;
     MSSPYSLSQP HTGEVSDLNQ QVWVLQGQTI VTVPRSNSVI PVTVTIVPCK YPESLEQGRG
     VPIYLGIENP EMCLSCEDIE GQPTLQLKEE KILRLYNEVE PVDPFLFYRL EIYSTSTFES
     VAFPGWFIAS SDKGHPIFLT SHQGENNVNF NLSINA
//
ID   M3YEA4_MUSPF            Unreviewed;       270 AA.
AC   M3YEA4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000009661};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSMPUP00000009661};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000009661, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000009661}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000009661};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000009661}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000009661}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEYP01076497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004771057.1; XM_004771000.2.
DR   STRING; 9669.ENSMPUP00000009661; -.
DR   Ensembl; ENSMPUT00000009817; ENSMPUP00000009661; ENSMPUG00000009737.
DR   GeneID; 101691850; -.
DR   CTD; 3552; -.
DR   eggNOG; ENOG410JAAI; Eukaryota.
DR   eggNOG; ENOG411151X; LUCA.
DR   GeneTree; ENSGT00390000013353; -.
DR   InParanoid; M3YEA4; -.
DR   OMA; NQKSFYD; -.
DR   OrthoDB; EOG76473H; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    111       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   270 AA;  31192 MW;  203C9DB4C19064A8 CRC64;
     MAKVPDLFED LQIFKKDLKN CYSENEEYSS EIDHLSLSQK SFYDVNYDPL HEDCMSLRTS
     ETSKTSHLTF KEDVVMVAAS GKILKKRRLS LNQFITDDDL EVITNDTEEE IMKPRSAAYN
     FRSNEKYNYM RIIKSQFILN DNLNQSIIQQ TGGNYLMAAA LQNLDDAVKF DMGAYTSEDS
     KFPVTLRISK TRLFVSAQNE GEPVLLKEMP ETPKTIKDET NLLFFWERHG TKNYFTSVAQ
     PKLFIATQER KLVHMAKGQP SITDFQILET
//
ID   M3YH89_MUSPF            Unreviewed;       168 AA.
AC   M3YH89;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 27.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|Ensembl:ENSMPUP00000010696};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSMPUP00000010696};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010696, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000010696}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000010696};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000010696}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000010696}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEYP01110470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01110471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9669.ENSMPUP00000010696; -.
DR   Ensembl; ENSMPUT00000010875; ENSMPUP00000010696; ENSMPUG00000010784.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; M3YH89; -.
DR   OMA; YPKKRME; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   168 AA;  19431 MW;  6D0C041845E023EC CRC64;
     EPIILEKCDD NAFVHDAPPR SLDCKFQDIN QKSLVLYNSY ELRALHLNGT SVNQQAVFRM
     TFVQEDEDIT KIPVALCIKE KNLYLSCVMK DGKPTLQLEM LDPKVYPKKR MEKRFVFNKT
     EIKKKVEFES SQFPNWYIST SQAEAMPVFL GNNRGGHDIT DFTMELSS
//
ID   M3ZG18_XIPMA            Unreviewed;       254 AA.
AC   M3ZG18;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 17.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000001160};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000001160, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000001160}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001160};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000001160}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001160};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000001160}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGAJ01035007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01035008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8083.ENSXMAP00000001160; -.
DR   Ensembl; ENSXMAT00000001163; ENSXMAP00000001160; ENSXMAG00000001168.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   InParanoid; M3ZG18; -.
DR   OMA; ESVKFRG; -.
DR   OrthoDB; EOG72G19J; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   254 AA;  28731 MW;  1AE7063CFA4EC1D2 CRC64;
     MSDFDLDDCS PDNRRPPSDT EQDVECDLKL SEDLNLMVTR NRTTMKRVAN LVLAVNKLNK
     SLSLCGRDLS DVALCGAIMD CMVEETVFQE AWNSFSGKPL FQRCSSVCEV TVSDERQKDL
     ILTTREMKLQ AITLKAGNCD REVNFKMCHY SPPSSINSLT VLLSVSKNLH ISCSMEDGKV
     SLILEQYSQE SLNEINQDDG LDRFLFFKTT PPRFESVKFR GWFISTSSVD VDPSVEMCQA
     DTSFRVTCFN VKHQ
//
ID   M3ZI95_XIPMA            Unreviewed;       349 AA.
AC   M3ZI95;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000001937};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000001937, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000001937}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001937};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000001937}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001937};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000001937}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGAJ01008225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSXMAT00000001942; ENSXMAP00000001937; ENSXMAG00000001939.
DR   eggNOG; ENOG410JGPV; Eukaryota.
DR   eggNOG; ENOG410YT8P; LUCA.
DR   GeneTree; ENSGT00390000016316; -.
DR   InParanoid; M3ZI95; -.
DR   OMA; ITIYYYK; -.
DR   OrthoDB; EOG7M6D88; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR001478; PDZ.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   349 AA;  39757 MW;  F6CB6977D67CC5DD CRC64;
     MDLDDSTVKG SVLIRHQLHE GKHHYEVEEV VKYQTKTDRF IRGDKLTEIN GVDLRDLEPE
     ELAKMIAEGN PLLSVQKREK QSEKEEQLPL DEDTLQPYDK ESTVLSFSWE LTREEGANEG
     EKNGTTDLKG NVCQDMSKEN GESRELLVIH MTNTSIAVVG TRGCEECEGT GCTVNDIVVV
     AESSAVTFVP RGDVSFRQEK LADVLIKHVP THRYLRTICS EKTVYSSPNP EKITIYYYKS
     NAMDRTFRGI AVVLNLTGSN CFLRCCKEGD RVLLQVETCE KQRLRQISKN DDCTFSFVFY
     MMADRTKQRK FESALHNGWF IHVANTDLVE MAETDGERGE SSFLFIIQK
//
ID   M4A1G7_XIPMA            Unreviewed;       189 AA.
AC   M4A1G7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 17.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000008311};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000008311, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000008311}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008311};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000008311}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008311};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000008311}.
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DR   EMBL; AGAJ01022085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01022086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8083.ENSXMAP00000008311; -.
DR   Ensembl; ENSXMAT00000008322; ENSXMAP00000008311; ENSXMAG00000008293.
DR   eggNOG; ENOG410KGER; Eukaryota.
DR   eggNOG; ENOG4110SCG; LUCA.
DR   GeneTree; ENSGT00520000060257; -.
DR   InParanoid; M4A1G7; -.
DR   OMA; MATCEDS; -.
DR   OrthoDB; EOG7DZ8N6; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   189 AA;  22206 MW;  EFAA0B63B2831827 CRC64;
     MATCEDSHLK FIETTNNSFY FEELHSDAFR RCEPPISTWI QSKDQKFLVL KTSGKFEFED
     RTVHDRGFTP ENLLRVLLIY QDSLLNNYQS VMLYVCADDE KMMISCKDNK EVCPEPMDPE
     VPKMIKAAAH KALFRWNCIS TGKYKFESTM YPGYFLGFER EEDMPCMHKL ILRQGSMDEV
     DERSIFCVN
//
ID   M4AQU2_XIPMA            Unreviewed;       144 AA.
AC   M4AQU2;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 21.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000016837};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000016837, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000016837}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016837};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000016837}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016837};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000016837}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGAJ01033579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01033580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8083.ENSXMAP00000016837; -.
DR   Ensembl; ENSXMAT00000016861; ENSXMAP00000016837; ENSXMAG00000016810.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   144 AA;  16266 MW;  06BD7D29B1171842 CRC64;
     QFSRREEHPC SVTDGQKRSL VLVRNNMELL AVMLQGGNDS RKGKTGXXXX XXXXXXXLGQ
     PVVLGIRDTD FYLSCHKDGD KPTLHLEEVE DKASLSEISV ESDMRRFLFY KRDMAVNIST
     LMSALFPNWY ISTATDNNRP VAMC
//
ID   M4WG34_SHEEP            Unreviewed;       266 AA.
AC   M4WG34;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   11-MAY-2016, entry version 21.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:AGI15465.2, ECO:0000313|Ensembl:ENSOARP00000022427};
GN   Name=IL1b {ECO:0000313|EMBL:AGI15465.2};
GN   Synonyms=IL1B {ECO:0000313|Ensembl:ENSOARP00000022427};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|EMBL:AGI15465.2};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022427, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022427};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|EMBL:AGI15465.2}
RP   NUCLEOTIDE SEQUENCE.
RA   Ren H.-L., Liu N.-N., Xu Y.-M., Tang F., Li C., Zou D.-Y., Feng X.-L.,
RA   Liu D., Guo X., Lu S.-Y., Liu Z.-S.;
RT   "Molecular cloning and recombinant expression of interleukin-1 beta.";
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSOARP00000022427}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2014) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; AMGL01077037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC425612; AGI15465.2; -; mRNA.
DR   UniGene; Oar.434; -.
DR   Ensembl; ENSOART00000022733; ENSOARP00000022427; ENSOARG00000020866.
DR   GeneTree; ENSGT00510000048687; -.
DR   OMA; SNDKIPV; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0042742; P:defense response to bacterium; TAS:AgBase.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:0050691; P:regulation of defense response to virus by host; TAS:AgBase.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    101       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   266 AA;  30675 MW;  BCF547A980E4AB64 CRC64;
     MATVPEPINE VMAYYSDANE LLFEVDGPKQ MKSCTQHLDL GSMGDGNIQL QISHQLYNKS
     FRQVVSVIVA MEKLRSRAYE HVFRDDDLRS ILSFIFEEEP VIFETSSDEL LCDAAVQSVK
     CKLQDREQKS LVLDSPCVLK ALHLLSQEMS REVVFCMSFV QGEERDNKIP VALGIRDKNL
     YLSCVKKGDT PTLQLEEVDP KVYPKRNMEK RFVFYKTEIK NTVEFESVLY PNWYISTSQI
     EEKPVFLGRF RGGQDITDFR METLSP
//
ID   M7AM46_CHEMY            Unreviewed;       181 AA.
AC   M7AM46;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 17.
DE   SubName: Full=Interleukin-1 receptor antagonist protein {ECO:0000313|EMBL:EMP26281.1};
GN   ORFNames=UY3_16653 {ECO:0000313|EMBL:EMP26281.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP26281.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
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DR   EMBL; KB581885; EMP26281.1; -; Genomic_DNA.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Receptor {ECO:0000313|EMBL:EMP26281.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   181 AA;  20224 MW;  E9E4EF070242DBF7 CRC64;
     MPGRKGTLVA VVSSAVRAIK EAHPSEIHEK PAAQMKVFKY RLWDVAQKSL YLRNNQLVAG
     YLQGPNSALE EKICWVPNRS FEREKFPIIL GVQDGRRSLA CGTGALPALQ LEDVNITELS
     RGGEETTRFT FFRSYKDGMW RFESAANPGW LLCTSAQSNE PLGLTTSPDA AHIVDFYFQL
     C
//
ID   M7ATM2_CHEMY            Unreviewed;       200 AA.
AC   M7ATM2;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 17.
DE   SubName: Full=Interleukin-36 receptor antagonist protein {ECO:0000313|EMBL:EMP26280.1};
GN   ORFNames=UY3_16652 {ECO:0000313|EMBL:EMP26280.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP26280.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; KB581885; EMP26280.1; -; Genomic_DNA.
DR   RefSeq; XP_007069935.1; XM_007069873.1.
DR   GeneID; 102932695; -.
DR   KEGG; cmy:102932695; -.
DR   KO; K05483; -.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Receptor {ECO:0000313|EMBL:EMP26280.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   200 AA;  22477 MW;  F31638A179E09C03 CRC64;
     MEPVSESVVD PDMEELFRLF LDEAAEGGGG TSNIQIMNFP TPGFGPTPGF RPSKQPFHYW
     IRDTRQKAFY LRDNRLVAAN LQGENASQEE KVSVVPNRGL ERKRCPLILG IKGGKQGLSC
     GTAKQPQLQL EDVQLTELFD KYEEAKRFTF FKTYNGSTHR FEAAAYPGWF LCTSAQANEP
     IGLTARPGEA AITDFYFKRK
//
ID   M7AWZ8_CHEMY            Unreviewed;       335 AA.
AC   M7AWZ8;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 16.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:EMP30021.1};
GN   ORFNames=UY3_12857 {ECO:0000313|EMBL:EMP30021.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP30021.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
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DR   EMBL; KB552459; EMP30021.1; -; Genomic_DNA.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN       58    160       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   335 AA;  37652 MW;  3F736F696B60A706 CRC64;
     MLWMCPRCLS CPGRSGFCAA AGSDTAFALR PPSSEDSVFH QQQCRVNVTK FHKREAAMAA
     VPDVQEELME FCSVNDEQFY EVDHPYLGKS SNQGSSPCSL SQSCSACDLG IQLQFTEQTS
     PKVFRRSVVL VIATEKMKKA LKARPFTDDD LTGIFDTVFE TISFESHNVT HTVDSIYRYF
     RSISYEIRDT DQKCFKLEAP AQLVAMHLQG PSITHQVKLN MALYRPKSGT SNQSSMRFPV
     ALGIKGRSLY LSCVQNGQQP VLQLEEADIL KDVDGAELER FIFYKVENES TAQFESAAHR
     GWYICTSPQN NQPVGITNRL GEVFITNYFL TQSKH
//
ID   M7AZ36_CHEMY            Unreviewed;       167 AA.
AC   M7AZ36;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-36 receptor antagonist protein {ECO:0000313|EMBL:EMP30024.1};
GN   ORFNames=UY3_12860 {ECO:0000313|EMBL:EMP30024.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP30024.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KB552459; EMP30024.1; -; Genomic_DNA.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Receptor {ECO:0000313|EMBL:EMP30024.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   167 AA;  19066 MW;  D5691E34B2B308DC CRC64;
     MRDLFDTFIK KEDGVPNPPD LPMPFIFNLR DAKQKVIRLQ SNHLVAEASN SDPEKLSVVP
     NRFVQGKQYP IILGVQGGSS CLSCGTLSQP KLQLEDKKIM ELFEDKEQAA RFTFHNIPEG
     STHRFESATY PGWFLCTSQK SSEPIRITNR PGETEITEFY FKRILTQ
//
ID   M7B3F5_CHEMY            Unreviewed;       263 AA.
AC   M7B3F5;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 15.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:EMP30020.1};
GN   ORFNames=UY3_12856 {ECO:0000313|EMBL:EMP30020.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP30020.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KB552459; EMP30020.1; -; Genomic_DNA.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   263 AA;  30032 MW;  6C821E2DD270B04A CRC64;
     MARVPDQLTE LIGCDSYHHE VDCPCQMKNR SLSELGSHWK AIDQVDSVAF RWAAEVPQGE
     TRRRMNRLAR SFTDIDFMRM LVEDPVSFSN NSFTHAETFI YKYTRSKLYA VQDEEHKSFV
     LRRHASQAQL MAVHLQGPNI SKAVKLNLDL YRSPHISPKR ISPVAMNIVE SNTVENNLYL
     CCVKAEGSPV LQLEKVKGPM KEIRTGDQER FLFFKTSSGS TSSFESAAHP GWFLSTSKLN
     DKPVRMVNQT GERDITDLYL VEL
//
ID   M7BD03_CHEMY            Unreviewed;       114 AA.
AC   M7BD03;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-36 receptor antagonist protein {ECO:0000313|EMBL:EMP30023.1};
GN   ORFNames=UY3_12859 {ECO:0000313|EMBL:EMP30023.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP30023.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KB552459; EMP30023.1; -; Genomic_DNA.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Receptor {ECO:0000313|EMBL:EMP30023.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   114 AA;  13022 MW;  A3D93F05E26EEA95 CRC64;
     MSPHSRNLCS SITSRRTLLD TQAMRTSQAP SWLPPSTHQQ LGTDRLIMDL YKHPEETKSF
     TFNNTLTGST HRFESATYLG WFRCTSQKSD EPLGITSRTG ESEITEFYFK KILG
//
ID   M7BD88_CHEMY            Unreviewed;       197 AA.
AC   M7BD88;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-18 {ECO:0000313|EMBL:EMP35134.1};
GN   ORFNames=UY3_07714 {ECO:0000313|EMBL:EMP35134.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP35134.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KB529689; EMP35134.1; -; Genomic_DNA.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   197 AA;  22998 MW;  1659A2C9416E7042 CRC64;
     MSCEEIRMFA VKFGQDFDLY FAGLECDNWK KEHSLQHQIF RNTSNQVLVV QPGPENTVTN
     VFESMADQEM IPGCGVHFTI HYYKDYTLEE GLPVAFSVLV ENKTYCMYCT HESGEKTIRF
     REEEVPREIH EQSSDIIFIQ KSVSPIHTKA FKFESSLMRG YFLAFQKEED LSKLILKQCE
     NEDQVDESIY MTVSQIN
//
ID   M7BPB2_CHEMY            Unreviewed;       148 AA.
AC   M7BPB2;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Interleukin-36 receptor antagonist protein {ECO:0000313|EMBL:EMP30022.1};
GN   ORFNames=UY3_12858 {ECO:0000313|EMBL:EMP30022.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP30022.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
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DR   EMBL; KB552459; EMP30022.1; -; Genomic_DNA.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Receptor {ECO:0000313|EMBL:EMP30022.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   148 AA;  16672 MW;  DBC2978BAD0AEA57 CRC64;
     MAVPGPSLFT LRDTSQKVIC CHHNRLLAPP RLPVPPPEKT SVVPNQFMDP SHFPIVMGID
     GGLCCLSCST SAQPTLMLED KKIMDLYQNS WEAERFTFTC SASSSTLRFE LVAFPGWYLS
     TSPRNDQPLW VTYHLGEAEI TNFYFKKV
//
ID   Q08FU8_DPV83            Unreviewed;       165 AA.
AC   Q08FU8;
DT   31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2006, sequence version 1.
DT   20-JAN-2016, entry version 32.
DE   SubName: Full=IL-1 receptor antagonist {ECO:0000313|EMBL:ABI99209.1};
GN   ORFNames=DpV83gp054 {ECO:0000313|EMBL:ABI99209.1};
OS   Deerpox virus (strain Mule deer/United States/W-848-83/1983) (DPV).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Cervidpoxvirus; unclassified Cervidpoxvirus.
OX   NCBI_TaxID=305674 {ECO:0000313|Proteomes:UP000000866};
OH   NCBI_TaxID=9872; Odocoileus hemionus (Mule deer) (Black-tailed deer).
RN   [1] {ECO:0000313|EMBL:ABI99209.1, ECO:0000313|Proteomes:UP000000866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mule deer/United States/W-848-83/1983
RC   {ECO:0000313|Proteomes:UP000000866};
RX   PubMed=15613325; DOI=10.1128/JVI.79.2.966-977.2005;
RA   Afonso C.L., Delhon G., Tulman E.R., Lu Z., Zsak A., Becerra V.M.,
RA   Zsak L., Kutish G.F., Rock D.L.;
RT   "Genome of deerpox virus.";
RL   J. Virol. 79:966-977(2005).
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DR   EMBL; AY689436; ABI99209.1; -; Genomic_DNA.
DR   RefSeq; YP_227429.1; NC_006966.1.
DR   GeneID; 3346395; -.
DR   KEGG; vg:3346395; -.
DR   KO; K05481; -.
DR   Proteomes; UP000000866; Genome.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000866};
KW   Receptor {ECO:0000313|EMBL:ABI99209.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000866}.
SQ   SEQUENCE   165 AA;  18683 MW;  E6C3E6B602792F0A CRC64;
     MKKLILLLVL YINIFNSKAA GMFMYSIWDV NQKIFYLRNN QLVAGNIQDN SLAEKITVKL
     NDGNSMFLGV KNGEKSLECT KHGDKVTLSL SDKKTNSLDE NQDKRFAFIR SDNGLTSTFE
     SVAFPGWFLC TSSGDGIEPV GLTYKGDKDD NDDDKNNIYF YFEED
//
ID   Q2VCE2_CANLF            Unreviewed;       265 AA.
AC   Q2VCE2; F1PTU3;
DT   10-JAN-2006, integrated into UniProtKB/TrEMBL.
DT   10-JAN-2006, sequence version 1.
DT   06-JUL-2016, entry version 85.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:ABB73214.1, ECO:0000313|Ensembl:ENSCAFP00000010762};
GN   Name=IL1B {ECO:0000313|EMBL:ABB73214.1,
GN   ECO:0000313|Ensembl:ENSCAFP00000010762};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|EMBL:ABB73214.1};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000010762, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000010762,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|EMBL:ABB73214.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Uterus {ECO:0000313|EMBL:ABB73214.1};
RA   Fenderson H.L., Volker C., Feild J.A.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ABB73214.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Uterus {ECO:0000313|EMBL:ABB73214.1};
RX   PubMed=16893658; DOI=10.1016/j.pep.2006.05.022;
RA   Kirkpatrick R.B., Grooms M., Wang F., Fenderson H., Feild J.,
RA   Pratta M.A., Volker C., Scott G., Johanson K.;
RT   "Bacterial production of biologically active canine interleukin-1beta
RT   by seamless SUMO tagging and removal.";
RL   Protein Expr. Purif. 50:102-110(2006).
RN   [4] {ECO:0000313|Ensembl:ENSCAFP00000010762}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000010762};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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DR   EMBL; AAEX03010912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ251036; ABB73214.1; -; mRNA.
DR   RefSeq; NP_001033060.1; NM_001037971.1.
DR   RefSeq; XP_005630131.1; XM_005630074.1.
DR   UniGene; Cfa.33592; -.
DR   STRING; 9615.ENSCAFP00000010762; -.
DR   Ensembl; ENSCAFT00000011613; ENSCAFP00000010762; ENSCAFG00000007249.
DR   GeneID; 403974; -.
DR   KEGG; cfa:403974; -.
DR   CTD; 3553; -.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   HOVERGEN; HBG007328; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-CFA-446652; Interleukin-1 signaling.
DR   Reactome; R-CFA-448706; Interleukin-1 processing.
DR   Proteomes; UP000002254; Chromosome 17.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    101       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   265 AA;  30143 MW;  B230A92177A44C25 CRC64;
     MAAVPELTSE MMAYSSNNEN DLFFEADGPG NVKCCCQDLN HSSLVDEGIQ LQVSHQLCNK
     SLRHFVSVIV ALEKLKKPCP QVLQEDDLKS IFCYIFEEEP IICKTDADNF MSDAAMQSVD
     CKLQDISHKY LVLSNSYELR ALHLNGENVN KQVVFHMSFV HGDESNNKIP VVLGIKQKNL
     YLSCVMKDGK PTLQLEKVDP KVYPKRKMEK RFVFNKIEIK NTVEFESSQY PNWYISTSQV
     EGMPVFLGNT RGGQDITDFT MEFSS
//
ID   Q3TBV5_MOUSE            Unreviewed;       162 AA.
AC   Q3TBV5;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   06-JUL-2016, entry version 84.
DE   SubName: Full=Interleukin-1 receptor antagonist protein {ECO:0000313|Ensembl:ENSMUSP00000110129};
GN   Name=Il1rn {ECO:0000313|Ensembl:ENSMUSP00000110129,
GN   ECO:0000313|MGI:MGI:96547};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000313|EMBL:BAE42202.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE42202.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAE42202.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE42202.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to
RT   prepare full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAE42202.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE42202.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
RA   Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
RA   Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
RA   Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
RA   Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
RA   Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format
RT   sequencing pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAE42202.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE42202.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAE42202.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE42202.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [6] {ECO:0000313|EMBL:BAE42202.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE42202.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
RA   Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
RA   Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
RA   Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
RA   Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
RA   Muramatsu M., Hayashizaki Y.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:BAE42202.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE42202.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAE42202.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE42202.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [9] {ECO:0000313|Ensembl:ENSMUSP00000110129, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000110129,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [10] {ECO:0000313|Ensembl:ENSMUSP00000110129}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000110129};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AL732528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK171037; BAE42202.1; -; mRNA.
DR   RefSeq; NP_001153034.1; NM_001159562.1.
DR   UniGene; Mm.882; -.
DR   STRING; 10090.ENSMUSP00000110126; -.
DR   Ensembl; ENSMUST00000114485; ENSMUSP00000110129; ENSMUSG00000026981.
DR   GeneID; 16181; -.
DR   UCSC; uc008iow.2; mouse.
DR   CTD; 3557; -.
DR   MGI; MGI:96547; Il1rn.
DR   eggNOG; ENOG410IZQ4; Eukaryota.
DR   eggNOG; ENOG41119SQ; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052099; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Proteomics identification {ECO:0000213|MaxQB:Q3TBV5,
KW   ECO:0000213|PeptideAtlas:Q3TBV5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   162 AA;  18280 MW;  D50AFFD004D43E9E CRC64;
     MTAAQAEAAC RPSGKRPCKM QAFRIWDTNQ KTFYLRNNQL IAGYLQGPNI KLEEKIDMVP
     IDLHSVFLGI HGGKLCLSCA KSGDDIKLQL EEVNITDLSK NKEEDKRFTF IRSEKGPTTS
     FESAACPGWF LCTTLEADRP VSLTNTPEEP LIVTKFYFQE DQ
//
ID   Q3U0P4_MOUSE            Unreviewed;       193 AA.
AC   Q3U0P4;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   06-JUL-2016, entry version 86.
DE   SubName: Full=Interleukin 1 family, member 9 {ECO:0000313|EMBL:EDL08162.1};
DE   SubName: Full=Interleukin-36 gamma {ECO:0000313|Ensembl:ENSMUSP00000053391};
GN   Name=Il1f9 {ECO:0000313|EMBL:EDL08162.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000053391, ECO:0000313|MGI:MGI:2449929};
GN   ORFNames=mCG_1029993 {ECO:0000313|EMBL:EDL08162.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000313|EMBL:BAE33808.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE43375.1}, and
RC   NOD {ECO:0000313|EMBL:BAE33808.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33808.1}, and
RC   Head {ECO:0000313|EMBL:BAE43375.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAE33808.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE43375.1}, and
RC   NOD {ECO:0000313|EMBL:BAE33808.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33808.1}, and
RC   Head {ECO:0000313|EMBL:BAE43375.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to
RT   prepare full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAE33808.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE43375.1}, and
RC   NOD {ECO:0000313|EMBL:BAE33808.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33808.1}, and
RC   Head {ECO:0000313|EMBL:BAE43375.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
RA   Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
RA   Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
RA   Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
RA   Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
RA   Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format
RT   sequencing pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAE33808.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE43375.1}, and
RC   NOD {ECO:0000313|EMBL:BAE33808.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33808.1}, and
RC   Head {ECO:0000313|EMBL:BAE43375.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAE33808.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE43375.1}, and
RC   NOD {ECO:0000313|EMBL:BAE33808.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33808.1}, and
RC   Head {ECO:0000313|EMBL:BAE43375.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [6] {ECO:0000313|EMBL:EDL08162.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed {ECO:0000313|EMBL:EDL08162.1};
RX   PubMed=12040188; DOI=10.1126/science.1069193;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
RA   Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
RA   Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
RA   Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
RA   Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
RA   Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
RA   Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
RA   Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
RA   Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
RA   Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
RA   Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
RA   Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
RA   Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
RA   Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
RA   Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
RA   Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
RA   Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
RA   Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
RA   Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
RA   Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
RA   Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
RA   Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
RA   Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
RA   Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
RA   Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
RA   Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
RA   Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
RA   Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
RA   Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
RA   Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
RA   Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
RA   Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
RT   "A comparison of whole-genome shotgun-derived mouse chromosome 16 and
RT   the human genome.";
RL   Science 296:1661-1671(2002).
RN   [7] {ECO:0000313|EMBL:BAE43375.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE43375.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAE43375.1};
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA   Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W.,
RA   Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T.,
RA   Hori F., Imotani K., Ishii Y., Itoh M., Kagawa I., Kasukawa T.,
RA   Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S.,
RA   Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M.,
RA   Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y.,
RA   Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H.,
RA   Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M.,
RA   Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T.,
RA   Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.;
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:BAE33808.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE33808.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33808.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
RA   Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
RA   Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
RA   Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
RA   Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
RA   Muramatsu M., Hayashizaki Y.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:BAE33808.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE43375.1}, and
RC   NOD {ECO:0000313|EMBL:BAE33808.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33808.1}, and
RC   Head {ECO:0000313|EMBL:BAE43375.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [10] {ECO:0000313|EMBL:BAE33808.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE43375.1}, and
RC   NOD {ECO:0000313|EMBL:BAE33808.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33808.1}, and
RC   Head {ECO:0000313|EMBL:BAE43375.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [11] {ECO:0000313|EMBL:EDL08162.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed {ECO:0000313|EMBL:EDL08162.1};
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|Ensembl:ENSMUSP00000053391, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000053391,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [13] {ECO:0000313|Ensembl:ENSMUSP00000053391}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000053391};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AL732430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK156687; BAE33808.1; -; mRNA.
DR   EMBL; AK081783; BAE43375.1; -; mRNA.
DR   EMBL; CH466542; EDL08162.1; -; Genomic_DNA.
DR   RefSeq; NP_705731.2; NM_153511.3.
DR   UniGene; Mm.249379; -.
DR   Ensembl; ENSMUST00000057567; ENSMUSP00000053391; ENSMUSG00000044103.
DR   GeneID; 215257; -.
DR   KEGG; mmu:215257; -.
DR   UCSC; uc008ioo.2; mouse.
DR   CTD; 215257; -.
DR   MGI; MGI:2449929; Il1f9.
DR   eggNOG; ENOG410J1V3; Eukaryota.
DR   eggNOG; ENOG4111C31; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOGENOM; HOG000231506; -.
DR   HOVERGEN; HBG052100; -.
DR   KO; K05487; -.
DR   OMA; VITCKYP; -.
DR   OrthoDB; EOG7034JW; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-MMU-449147; Signaling by Interleukins.
DR   Proteomes; UP000000589; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Proteomics identification {ECO:0000213|MaxQB:Q3U0P4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22000 MW;  B7BCEC4CF9942285 CRC64;
     MENNEKKNIV YGSDVEMEHE RAGLFVSSAM FSKHPFSTHI SGRETPDFGE VFDLDQQVWI
     FRNQALVTVP RSHRVTPVSV TILPCKYPES LEQDKGIAIY LGIQNPDKCL FCKEVNGHPT
     LLLKEEKILD LYHHPEPMKP FLFYHTRTGG TSTFESVAFP GHYIASSKTG NPIFLTSKKG
     EYYNINFNLD IKS
//
ID   Q5BKB0_RAT              Unreviewed;       268 AA.
AC   Q5BKB0;
DT   12-APR-2005, integrated into UniProtKB/TrEMBL.
DT   12-APR-2005, sequence version 1.
DT   08-JUN-2016, entry version 96.
DE   SubName: Full=Interleukin 1 beta {ECO:0000313|EMBL:AAH91141.1};
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|Ensembl:ENSRNOP00000006308};
GN   Name=Il1b {ECO:0000313|EMBL:AAH91141.1,
GN   ECO:0000313|Ensembl:ENSRNOP00000006308, ECO:0000313|RGD:2891};
GN   ORFNames=rCG_27107 {ECO:0000313|EMBL:EDL80163.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH91141.1};
RN   [1] {ECO:0000313|EMBL:AAH91141.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen {ECO:0000313|EMBL:AAH91141.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000006308, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000006308,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [3] {ECO:0000313|EMBL:EDL80163.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL80163.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [4] {ECO:0000313|EMBL:EDL80163.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL80163.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA   Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA   Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Ensembl:ENSRNOP00000006308}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000006308};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
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CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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DR   EMBL; AABR07053713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC091141; AAH91141.1; -; mRNA.
DR   EMBL; CH473949; EDL80163.1; -; Genomic_DNA.
DR   RefSeq; NP_113700.2; NM_031512.2.
DR   UniGene; Rn.9869; -.
DR   STRING; 10116.ENSRNOP00000006308; -.
DR   Ensembl; ENSRNOT00000006308; ENSRNOP00000006308; ENSRNOG00000004649.
DR   GeneID; 24494; -.
DR   KEGG; rno:24494; -.
DR   CTD; 3553; -.
DR   RGD; 2891; Il1b.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   HOVERGEN; HBG007328; -.
DR   KO; K04519; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-RNO-446652; Interleukin-1 signaling.
DR   Reactome; R-RNO-448706; Interleukin-1 processing.
DR   Reactome; R-RNO-5660668; CLEC7A/inflammasome pathway.
DR   Proteomes; UP000002494; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR028142; IL-1_fam/FGF_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    102       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   268 AA;  30659 MW;  179B699CF1EB2428 CRC64;
     MATVPELNCE IAAFDSEEND LFFEADRPQK IKDCFQALDL GCPDESIQLQ ISQQHLDKSF
     RKAVSLIVAV EKLWQLPMSC PWSFQDEDPS TFFSFIFEEE PVLCDSWDDD DLLVCDVPIR
     QLHCRLRDEQ QKCLVLSDPC ELKALHLNGQ NISQQVVFSM SFVQGETSND KIPVALGLKG
     KNLYLSCVMK DGTPTLQLES VDPKQYPKKK MEKRFVFNKI EVKTKVEFES AQFPNWYIST
     SQAEHRPVFL GNSNGRDIVD FTMEPVSS
//
ID   Q6IT44_CHICK            Unreviewed;       196 AA.
AC   Q6IT44;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2005, sequence version 2.
DT   06-JUL-2016, entry version 83.
DE   SubName: Full=Interleukin 18 {ECO:0000313|EMBL:AAT40993.2};
DE   SubName: Full=Interleukin-18 {ECO:0000313|Ensembl:ENSGALP00000012772};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSGALP00000012772};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000012772, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000012772,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|EMBL:AAT40993.2}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:AAT40993.2};
RX   PubMed=16215636; DOI=10.1111/j.1745-7270.2005.00098.x;
RA   Xu J., Deng T.L., Li L., You Z.Q., Wan W.J., Yu L.;
RT   "Nitric oxide inducing function and intracellular movement of chicken
RT   interleukin-18 in cultured cells.";
RL   Acta Biochim. Biophys. Sin. 37:688-693(2005).
RN   [3] {ECO:0000313|EMBL:AAX18248.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Qin Z.H., Cai J.P., Ye X.H., Wang P.Y., Chen W., Xie M.Q.;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSGALP00000012772}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000012772};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AADN03008267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY628648; AAT40993.2; -; mRNA.
DR   EMBL; AY920749; AAX18248.1; -; mRNA.
DR   UniGene; Gga.17593; -.
DR   STRING; 9031.ENSGALP00000012772; -.
DR   Ensembl; ENSGALT00000012787; ENSGALP00000012772; ENSGALG00000007874.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   HOVERGEN; HBG102119; -.
DR   OMA; AFKFEYS; -.
DR   OrthoDB; EOG7SR4NN; -.
DR   TreeFam; TF336297; -.
DR   Reactome; R-GGA-448706; Interleukin-1 processing.
DR   Reactome; R-GGA-449147; Signaling by Interleukins.
DR   Proteomes; UP000000539; Chromosome 24.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0035710; P:CD4-positive, alpha-beta T cell activation; IDA:AgBase.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:1902715; P:positive regulation of interferon-gamma secretion; IDA:AgBase.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0050671; P:positive regulation of lymphocyte proliferation; IDA:AgBase.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   196 AA;  22688 MW;  4947DED466183514 CRC64;
     MSCEEIAVCA VRLRENLCLY FEELECDAFC KDKTIKRFFR NVNSQLLVVR PDLNVAAFED
     VTDQEVKSGS GMYFDIHCYK TTAPSAGMPV AFSVQVEDKS YYMCCEKEHG KMVVRFREGE
     VPKDIPGESN IIFFKKTFTS CSSKAFKFEY SLEQGMFLAF EEEDSLRKLI LKKLPREDEV
     DETTKFVTSH NERHNL
//
ID   Q712K7_ORNAN            Unreviewed;       290 AA.
AC   Q712K7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   08-JUN-2016, entry version 80.
DE   SubName: Full=Interleukin-1 beta {ECO:0000313|EMBL:CAC80337.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000016712};
GN   Name=il-1 beta {ECO:0000313|EMBL:CAC80337.1};
GN   Synonyms=IL1B {ECO:0000313|Ensembl:ENSOANP00000016712};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258;
RN   [1] {ECO:0000313|EMBL:CAC80337.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Skin {ECO:0000313|EMBL:CAC80337.1};
RA   Bird S., Zou J., Secombes C.J.;
RT   "Evolution of the interleukin-1 beta gene in vertebrates.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [3] {ECO:0000313|Ensembl:ENSOANP00000016712}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016712};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Potent proinflammatory cytokine. Initially discovered as
CC       the major endogenous pyrogen, induces prostaglandin synthesis,
CC       neutrophil influx and activation, T-cell activation and cytokine
CC       production, B-cell activation and antibody production, and
CC       fibroblast proliferation and collagen production.
CC       {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -----------------------------------------------------------------------
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DR   EMBL; AJ239048; CAC80337.1; -; Genomic_DNA.
DR   STRING; 9258.ENSOANP00000016712; -.
DR   Ensembl; ENSOANT00000016715; ENSOANP00000016712; ENSOANG00000010546.
DR   eggNOG; ENOG410IGSZ; Eukaryota.
DR   eggNOG; ENOG410XU2E; LUCA.
DR   GeneTree; ENSGT00510000048687; -.
DR   HOGENOM; HOG000246399; -.
DR   HOVERGEN; HBG007328; -.
DR   OMA; SNDKIPV; -.
DR   OrthoDB; EOG71P2BQ; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002279; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1    117       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   290 AA;  32846 MW;  EBEF1EC17DD67AF1 CRC64;
     MARVPDQSRD LMECYSGDGE DQFYEVDGPS QIKSGFQDLK ARTCQETRIH KEDKCSPCQM
     GIELKVTELP SSHGFRKAVV LVVAVERIKR QAVSYNTSFM DRDLMDIFTS IFKEEPISCS
     TWEQTLVTDS LYHYLRCQEV TIWDEEHKSF TLNTMANPCE LRALHLIGAN ATQEVKLNMN
     FYYKTERLAG PTVKQPVTLG IKGGNPGNLY LSCVKKGGKP TLQLEVVNKS DLLGKNQERF
     IFNKSTEGTS TTFESAAYPD WYISTSREED EPVFLGASKG EEAITNFFLH
//
ID   R4G9C5_ANOCA            Unreviewed;       186 AA.
AC   R4G9C5;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   08-JUN-2016, entry version 19.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000021818};
GN   Name=LOC100551946 {ECO:0000313|Ensembl:ENSACAP00000021818};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Iguanidae; Polychrotinae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000021818, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000021818}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L.,
RA   Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A.,
RA   Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K.,
RA   Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A.,
RA   Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y.,
RA   Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D.,
RA   de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z.,
RA   Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A.,
RA   Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S.,
RA   Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with
RT   birds and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000021818}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000021818}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_003224252.1; XM_003224204.2.
DR   Ensembl; ENSACAT00000029237; ENSACAP00000021818; ENSACAG00000028772.
DR   GeneID; 100551946; -.
DR   KEGG; acs:100551946; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   KO; K05481; -.
DR   Proteomes; UP000001646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   186 AA;  20826 MW;  77804FD658676948 CRC64;
     MEMTVEMKPK KSIAEEMADL FHEFPNPKDT VTTAELAKPW NYQIWDLSQK YLSLSNNTLV
     AAPKGSNSPE EVLAVVPNRG FENSSSTIFP IFMGLQDGNR VLSCIETGAQ PQISIMEEGI
     MKLYKNVQPF KNFTFLNHPE DSQQTCSFES AAFPGWFLST STEPNKPIGL SRKGGAEIAT
     FYFIKK
//
ID   U3IE90_ANAPL            Unreviewed;       204 AA.
AC   U3IE90;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   11-MAY-2016, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAPLP00000005562};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSAPLP00000005562};
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anas.
OX   NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000005562, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000005562}
RP   NUCLEOTIDE SEQUENCE.
RA   Li N.;
RT   "The genome sequence and transcriptome of duck provide insight into
RT   the interaction host.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000005562}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23749191; DOI=10.1038/ng.2657;
RA   Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H.,
RA   Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q.,
RA   Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A.,
RA   Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J.,
RA   Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G.,
RA   Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M.,
RA   Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J.,
RA   Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J.,
RA   Li N.;
RT   "The duck genome and transcriptome provide insight into an avian
RT   influenza virus reservoir species.";
RL   Nat. Genet. 45:776-783(2013).
RN   [3] {ECO:0000313|Ensembl:ENSAPLP00000005562}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAPLP00000005562}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ADON01146900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAPLT00000006193; ENSAPLP00000005562; ENSAPLG00000005942.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; AFKFEYS; -.
DR   Proteomes; UP000016666; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016666};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   204 AA;  23796 MW;  6FFDD9AEF5303C82 CRC64;
     FYNTPLSHNF PLSFFSLKYC SQKLLTWNQD DDELECDAFS KEKTLHRFLR NVNSQVLVVQ
     PDLNMAAFED VTDQEMKSGS GMNFCMHCYK TTTPSAGMPV AFSVRVEDKS YYMCCEEEHG
     KMIVRFREGE VPKDIPGESN IIFFKKTFTS YSSKAFKFEY SLERGMFLAF EEEDSLRKLI
     LKKLPREDEV DETTKITLTS HNER
//
ID   U3JBA1_FICAL            Unreviewed;       303 AA.
AC   U3JBA1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   06-JUL-2016, entry version 18.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000000055};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSFALP00000000055};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000000055, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000000055}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFALP00000000055}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTO01001548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016159081.1; XM_016303595.1.
DR   Ensembl; ENSFALT00000000055; ENSFALP00000000055; ENSFALG00000000051.
DR   GeneID; 101819115; -.
DR   GeneTree; ENSGT00510000048687; -.
DR   OMA; HAMSIIV; -.
DR   Proteomes; UP000016665; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0032611; P:interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
DR   GO; GO:0070164; P:negative regulation of adiponectin secretion; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0010829; P:negative regulation of glucose transport; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0035505; P:positive regulation of myosin light chain kinase activity; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR   GO; GO:0032308; P:positive regulation of prostaglandin secretion; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0009743; P:response to carbohydrate; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 2.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1     93       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   303 AA;  33236 MW;  D88AEA7D32290B6B CRC64;
     MAFVPDLDTL ESNSLNEEML YGPNCLCPQK KPRLDLEVTS PGVGIQVTVT KGHLSRTFRQ
     AAVLVAAVTK LLKQPSHNDF SDSDLGSFFD DIFGMRLMSG VSPQTEDILG GTLGPGSSIL
     LTVSLPTEPV SFQCIKGSYT KAPVFRYTRS QSFDILDVDH KCFVLESPTQ LVALHLQGPS
     AGRKVKLDIA LYRPRSSQGG PRSGRVPVAL GIKGYQLYMS CVMSDTQPVL QLEEADIRRD
     LESVELTRFI FYRLDSPAEG TTRFESAAFP GWFVCTSLQP RQPVGITNTP DQVNIATYEL
     SGH
//
ID   U3JBA2_FICAL            Unreviewed;       269 AA.
AC   U3JBA2;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   06-JUL-2016, entry version 17.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000000056};
GN   Name=IL1B {ECO:0000313|Ensembl:ENSFALP00000000056};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000000056, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000000056}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFALP00000000056}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTO01001548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005057946.1; XM_005057889.1.
DR   Ensembl; ENSFALT00000000056; ENSFALP00000000056; ENSFALG00000000051.
DR   GeneID; 101819115; -.
DR   KEGG; fab:101819115; -.
DR   GeneTree; ENSGT00510000048687; -.
DR   KO; K04519; -.
DR   Proteomes; UP000016665; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN        1     94       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   269 AA;  29868 MW;  530209A45BF8998F CRC64;
     MAFVPDLDTL ESNSLNEEML YGPNCLCPQK KPRLDLEVTS PGVGIQVTVT KGHLSRTFRQ
     AAVLVAAVTK LLKQPSHNDF SDSDLGSFFD DIFEPVSFQC IKGSYTKAPV FRYTRSQSFD
     ILDVDHKCFV LESPTQLVAL HLQGPSAGRK VKLDIALYRP RSSQGGPRSG RVPVALGIKG
     YQLYMSCVMS DTQPVLQLEE ADIRRDLESV ELTRFIFYRL DSPAEGTTRF ESAAFPGWFV
     CTSLQPRQPV GITNTPDQVN IATYELSGH
//
ID   U3JSG2_FICAL            Unreviewed;       247 AA.
AC   U3JSG2;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   11-MAY-2016, entry version 16.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000005716};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000005716, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000005716}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFALP00000005716}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTO01022958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFALT00000005743; ENSFALP00000005716; ENSFALG00000005488.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; FALCHAP; -.
DR   Proteomes; UP000016665; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   247 AA;  24866 MW;  73500D4832B6FD07 CRC64;
     MGERCPGGRG HGALGTGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG
     GAGRGRGALL VATLSLALLF LRAEAEGFAL CHAPALQTEV FQYRLWDVNQ RSLYLRDGHL
     VAGHLQGANA ALEEKVFWVP NRALEPARLP VILGIQHGSR CLSAERGPRG EPRLSLQDVD
     IRELPRAGDS AAAFTFFRSY RDGLWRFESA AHPGWFLCTA PRGHQPLALC RHRDVASNLI
     DFYFQLC
//
ID   U3JUL9_FICAL            Unreviewed;       194 AA.
AC   U3JUL9;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000006473};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSFALP00000006473};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000006473, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000006473}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFALP00000006473}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTO01010988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFALT00000006502; ENSFALP00000006473; ENSFALG00000006206.
DR   GeneTree; ENSGT00390000001053; -.
DR   Proteomes; UP000016665; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   194 AA;  22541 MW;  E403CD3F4C758B49 CRC64;
     MLFFFPFFSL LPWNQDDDEL ECDALCKEKI LHRVLRNVHS QLLVVRPDLN VAAFEDVTDQ
     EMQSGKGMHF SIHCYKTTTP LAGMPVAFSV QVENKSYYMC CEREGGEMIV RFKEGEVPKE
     IPGESNIIFF KKTFTSCSSR AFKFEYSLER GMFLAFEQEG YLRKLILKKV PQDEVDETMK
     MSLSTFSQNE NHNL
//
ID   U3JUM1_FICAL            Unreviewed;       207 AA.
AC   U3JUM1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   11-MAY-2016, entry version 17.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000006475};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSFALP00000006475};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000006475, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000006475}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFALP00000006475}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTO01010988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFALT00000006504; ENSFALP00000006475; ENSFALG00000006206.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; AFKFEYS; -.
DR   Proteomes; UP000016665; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   207 AA;  23848 MW;  ACD41E4C610FDD2E CRC64;
     MSAEEILVLA VKLGKNFCLY FDVLPWNQDD DELECDALCK EKILHRVLRN VHSQLLVVRP
     DLNVAAFEDV TDQEMQSGKG MHFSIHCYKT TTPLAGMPVA FSVQVENKSY YMCCEREGGE
     MIVRFKEGEV PKEIPGESNI IFFKKTFTSC SSRAFKFEYS LERGMFLAFE QEGYLRKLIL
     KKVPQDEVDE TMKMSLSTFS QNENHNL
//
ID   U3KPW9_HUMAN            Unreviewed;        52 AA.
AC   U3KPW9;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   11-MAY-2016, entry version 20.
DE   SubName: Full=Interleukin-36 receptor antagonist protein {ECO:0000313|Ensembl:ENSP00000475308};
DE   Flags: Fragment;
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSP00000475308};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000475308, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000475308, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000475308}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000475308}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
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CC   -----------------------------------------------------------------------
DR   EMBL; AC016724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9606.ENSP00000259212; -.
DR   PaxDb; U3KPW9; -.
DR   Ensembl; ENST00000514072; ENSP00000475308; ENSG00000136695.
DR   UCSC; uc061nbq.1; human.
DR   HGNC; HGNC:15561; IL36RN.
DR   eggNOG; ENOG410IZIW; Eukaryota.
DR   eggNOG; ENOG41116AA; LUCA.
DR   GeneTree; ENSGT00530000062899; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   ExpressionAtlas; U3KPW9; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000475308}.
SQ   SEQUENCE   52 AA;  5812 MW;  9B897861D1D33FE2 CRC64;
     XMGLTSSFES AAYPGWFLCT VPEADQPVRL TQLPENGGWN APITDFYFQQ CD
//
ID   V8NB61_OPHHA            Unreviewed;       293 AA.
AC   V8NB61;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   11-MAY-2016, entry version 12.
DE   SubName: Full=Interleukin-1 receptor antagonist protein {ECO:0000313|EMBL:ETE58888.1};
DE   Flags: Fragment;
GN   Name=IL1RN {ECO:0000313|EMBL:ETE58888.1};
GN   ORFNames=L345_15384 {ECO:0000313|EMBL:ETE58888.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE58888.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE58888.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE58888.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE58888.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AZIM01006149; ETE58888.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 2.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 2.
DR   PROSITE; PS00253; INTERLEUKIN_1; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Receptor {ECO:0000313|EMBL:ETE58888.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE58888.1}.
FT   NON_TER     293    293       {ECO:0000313|EMBL:ETE58888.1}.
SQ   SEQUENCE   293 AA;  33040 MW;  A9E0402DACC0AA94 CRC64;
     MASTLHKKTW DEDVADLFHD SEPDPEIRPS VEASPRLYKL WDLNQKYLFL VENTLVADVK
     TSNLPEQLIA VLPNKTLDTA QKPIFMGPEN KKSCLSCVKS GNGQYQIELK EKDIMDLYRD
     PKNTKAFTFY SKSADNADTC SFESAEFPGW FLSTSSEAKK PIEPSLPAPE MTNAPWQFKF
     WDISNKFLSV VNNVLIATPQ NSNSPGSSFD VIPNTSLDPK RNPIFIGADN HEENIMILYR
     TPEKFKNFTF YSKSDGRPEI CTFESAEFPG WFISTSSEPN KPIGLSQKGG PEN
//
ID   V8NJN5_OPHHA            Unreviewed;       192 AA.
AC   V8NJN5;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   11-MAY-2016, entry version 11.
DE   SubName: Full=Interleukin-18 {ECO:0000313|EMBL:ETE61868.1};
DE   Flags: Fragment;
GN   Name=IL18 {ECO:0000313|EMBL:ETE61868.1};
GN   ORFNames=L345_12377 {ECO:0000313|EMBL:ETE61868.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE61868.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE61868.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE61868.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE61868.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AZIM01003605; ETE61868.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE61868.1}.
SQ   SEQUENCE   192 AA;  22091 MW;  8BC09EEF25B12374 CRC64;
     MIQMQPMILD QGGNLYFQET DSWKTSGKCE PAQVFRSPNN HVLIARPADE DFPAVFERRT
     DQEIRNVSGI RFDIHSYQDT KPKGLCVAFT VEFNHQIYHM CVEKKENKMR VNFKEGTIPK
     NIEGDTSNII FIKTQFSSGS RQFYKFESAL ERGYFLAFEC VKGSSETVLV VKKVELADEV
     DESIKLHHAT LL
//
ID   V8PCJ5_OPHHA            Unreviewed;       253 AA.
AC   V8PCJ5;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   11-MAY-2016, entry version 12.
DE   SubName: Full=Interleukin-1 family member 10 {ECO:0000313|EMBL:ETE71733.1};
DE   Flags: Fragment;
GN   Name=Il1f10 {ECO:0000313|EMBL:ETE71733.1};
GN   ORFNames=L345_02426 {ECO:0000313|EMBL:ETE71733.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE71733.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE71733.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE71733.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE71733.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AZIM01000318; ETE71733.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:GOC.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 2.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 2.
DR   PROSITE; PS00253; INTERLEUKIN_1; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER     253    253       {ECO:0000313|EMBL:ETE71733.1}.
SQ   SEQUENCE   253 AA;  28635 MW;  1F1324E43A42855E CRC64;
     MAVVPNDNLD FRNRPIFMGL TGKTKALSCL KSITGEPQLV ILEKNIMDFY RDTKEFKNFS
     FYVVTRGNKS NCWFESAAFP GWFLSTSIHP NMPVGLCKQG AYYPDLKMSC LKPSKPPHVL
     EPLRLREPRL FRIWDISQKF LFIVNSMLIA NPLDFNSPDP RQQPIFMGLT DGSHTLSCTS
     SSEGQPQLHL VMDGSSETCS FESAQFPGWF ISTSSEPNKP INLGQKGGTE ITLFYFETSE
     RKEKGELVIT RVI
//
ID   V8PFB5_OPHHA            Unreviewed;       121 AA.
AC   V8PFB5;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   11-MAY-2016, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE73025.1};
DE   Flags: Fragment;
GN   ORFNames=L345_01138 {ECO:0000313|EMBL:ETE73025.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE73025.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE73025.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE73025.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE73025.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AZIM01000144; ETE73025.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE73025.1}.
SQ   SEQUENCE   121 AA;  13550 MW;  95E987F8A187D9D5 CRC64;
     MTAPHPRLQE KIFWIRNRAF GQENFPVILS IQGGKSSLAC SPGSPPELQL ESVNITDLCR
     DKEASTRFTF FMSSKDGIWR FESAAHPGWF LCTSSKANEP IGLINDPGSS HLVDFYFQPE
     S
//
ID   V8PGF3_OPHHA            Unreviewed;       366 AA.
AC   V8PGF3;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   11-MAY-2016, entry version 12.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETE73026.1};
DE   Flags: Fragment;
GN   ORFNames=L345_01139 {ECO:0000313|EMBL:ETE73026.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE73026.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE73026.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE73026.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE73026.1}.
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DR   EMBL; AZIM01000144; ETE73026.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003296; IL-1_beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   PANTHER; PTHR10078:SF20; PTHR10078:SF20; 1.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN      167    220       IL1_propep. {ECO:0000259|Pfam:PF02394}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE73026.1}.
SQ   SEQUENCE   366 AA;  40708 MW;  9958DE0DDDAEE07B CRC64;
     MPALPTASAP SSAPESETFD PENPRTGGQL VEQRESLPGW SSSPEGLQPS HQQDAVLRSG
     PAVPDTGKLL DHLLLLERGS CAQTRTFGRS FVNIRLELQT WAFPSHLVLQ RVSGAQLKLF
     NLMDQPYLFP SLSLFLKDGR RKGPRPGLDS ASRELDWLLF TFQKAFQDSK VDVQVAVTKN
     EPLKSFRKAV LIVIASETMR KSPASLFSDE DLLDILSTIL EPVTFDICSS TEATSSIYHF
     WRNIIYNIQD TDHKSLVCKE PAQLVAMHLQ GLNMEQAVKL KMSVYRPKIE AGTQKVPVEA
     TIQGNLDKSQ LGRFLFYKIE NGKHTRFESA ECPGWFICTS SQNDEAVAVT KQPGGPRVIV
     DYSLTS
//
ID   W5KMA5_ASTMX            Unreviewed;       353 AA.
AC   W5KMA5;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000008717};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000008717, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000008717, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000008717}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000008717}.
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DR   EMBL; APWO01116195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000008717; ENSAMXP00000008717; ENSAMXG00000008483.
DR   GeneTree; ENSGT00390000016316; -.
DR   OMA; ITIYYYK; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   353 AA;  39967 MW;  67EEC7C07335193B CRC64;
     LGSQGSLLRG GVSLCHSLVD EKHCYEVEKA LTHSSSTFRK GDIVSMINNK KTQDLSPKEF
     ISLLTSESPI LTLHQAIIVK EEGQCPESDS IHAFRKEKST LSFQLVMVRE ECLEAEEKNE
     IKPTESSWES DDMKEKDLVM VSMTETNVAV VRGRGCDPEN PCNNCGITGC NVSDVIMAPK
     KREVTSVCRK SVWMGDEEKV QDVIMYSLLG TIQRPLYIRP VSFSVCLSED ITIYFYRSNI
     LEDLSRGSPV VLNFTGSTNF LKCTRVNQEV GLTVESYEKE KLKDICKDDP VTWPFVFYMK
     TRRDNTRLFE SAQNKGWFIR TEKPQVSVWM GNPTIRTQGM NTFASAVPRC LFC
//
ID   W5KMC2_ASTMX            Unreviewed;       364 AA.
AC   W5KMC2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000008734};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000008734, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000008734, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000008734}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000008734}.
CC   -----------------------------------------------------------------------
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CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; APWO01116196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000008734; ENSAMXP00000008734; ENSAMXG00000008500.
DR   GeneTree; ENSGT00390000016316; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   364 AA;  41965 MW;  169661AFEB41F9DA CRC64;
     LFLQGKSIRG GVSLCHSLVN EKHCYEVEKA LTHCSTVFLS HSFYRKGDII SMINNEKTED
     MPPRMFISML SSRSPILTIH QASTDMEEGQ CLESDSIHVF RKEELTLNFK LEMVREECLE
     AEEENEIEPE WESDDMEDKE LVMVSMTETN VAVVRGRGCD LENPCNNCGI NGCNVSEVFM
     EAKNRDVTSV CRGSVSMGGR NIVRDVVMSS LLQNYVKSKQ LAFSGIRQLW TWVSFSTFCL
     SENVTIYYYQ SDITEDGKIS YPVVLNLTGT NKFLKCTRNN EEVILTTESY EKDKLKDICK
     DNPATWPFVF FMKTEDVNNR LFESAENRGW FIRTVNEQGF LWVNKIDESK EPFYFLIYLD
     TENN
//
ID   W5KMD6_ASTMX            Unreviewed;       277 AA.
AC   W5KMD6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000008748};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000008748, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000008748, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000008748}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000008748}.
CC   -----------------------------------------------------------------------
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CC   -----------------------------------------------------------------------
DR   EMBL; APWO01116198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007259441.1; XM_007259379.1.
DR   Ensembl; ENSAMXT00000008748; ENSAMXP00000008748; ENSAMXG00000008514.
DR   GeneID; 103025024; -.
DR   GeneTree; ENSGT00390000016316; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   277 AA;  31685 MW;  413BFF41742DB78C CRC64;
     MPPKEFIRML SSESPMLTIH QAIVDNEEDH CLEADSIRAI GQEKITLSFQ LEMVREECLE
     AEEENKIWES DEMEDKEDLV MVSMTKTNVA VVCGRGCDPE NPCSNCNINK CKTSEVVVTA
     TKSEVTSVSS QSLMMKTKLD VVMCSLVKIW SCKNVPFSED ITIFYYCSNI FEDLSRGSPV
     VLNFTGSTNF LKCTCKDQKI GLTIESFDKE KLRNICKDDP DAWPFVFYMK TERSDYRVFE
     SAAYRGWFIR TAKSMTVGNR TSETQENFCF LVYSKNK
//
ID   W5MG35_LEPOC            Unreviewed;       190 AA.
AC   W5MG35;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLOCP00000007344};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSLOCP00000007344};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007344, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000007344, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000007344}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLOCP00000007344}.
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DR   EMBL; AHAT01018445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01018446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLOCT00000007352; ENSLOCP00000007344; ENSLOCG00000006081.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; CDKESSH; -.
DR   Proteomes; UP000018468; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   190 AA;  21776 MW;  0F4A7303B1B8B2EE CRC64;
     PVGMSEFQCM EFAAVLENEI FFAGSPADIE EDSFRRMNKC LSRMIRNKNH QFLVADQGLV
     FENGPVEQAP FADRRFSIEM YGTTECARGV AVVIRFFSEG CWHVVRCTQE GSRKKVEASP
     QSEQVPDYVP DSCNDAVFFL QAVEGQSNKF MFESSRWRCW FLAFSAEGGF YKLVLQPRAD
     EVDERQLFTL
//
ID   W5Q3V0_SHEEP            Unreviewed;       193 AA.
AC   W5Q3V0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000017389};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSOARP00000017389};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000017389, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000017389, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000017389}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000017389}.
CC   -----------------------------------------------------------------------
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CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01031240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000017636; ENSOARP00000017389; ENSOARG00000016193.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; PVFEDMP; -.
DR   Proteomes; UP000002356; Chromosome 15.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   193 AA;  22166 MW;  CCC54329062EF18C CRC64;
     MAAEPVEDNC ISFVEMKFIN NTLYFVAENG EDLESDHFGK LEPKLSIIRN LNDQVLFISQ
     GNQPVFEDMP DSDCSDNAPQ TIFIIYMYKD SLTRGLAVTI SVQCKKMSTL SCENKIISFK
     EMNPPDNIDN EGSDIIFFQR SVPGHDDKIQ FESSLYKGYF LACKKENDLF KLILKRQDDN
     RDKSIMFTVQ NQN
//
ID   W5QI35_SHEEP            Unreviewed;       174 AA.
AC   W5QI35;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   08-JUN-2016, entry version 19.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000022386};
GN   Name=IL1RN {ECO:0000313|Ensembl:ENSOARP00000022386};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022386, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022386, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022386}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000022386}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01077025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000022692; ENSOARP00000022386; ENSOARG00000020828.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; IHGGKLC; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027166; IL-1RA.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   PANTHER; PTHR10078:SF21; PTHR10078:SF21; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    174       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004871783.
SQ   SEQUENCE   174 AA;  19810 MW;  6B31372D5DA332F1 CRC64;
     MDIYIHGYLI CLLLFLFHSE TACHPLGKRP CEMQAFRIWD VNQKIFYLRN NQLVAGYLQE
     ANIKLEEKID VVPIEPHTMF LGIHGGKLCL ACVKSGDEIK LKLEAVNITD LNQNREQDKR
     FAFIRSDNGP TTSFESAACP GWFLCTSLEA DQPVGLTNTP TEAIKVTRFY LQQD
//
ID   W5QI42_SHEEP            Unreviewed;       157 AA.
AC   W5QI42;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 12.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000022393};
DE   Flags: Fragment;
GN   Name=IL1F10 {ECO:0000313|Ensembl:ENSOARP00000022393};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022393, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022393, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022393}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000022393}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01077026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000022699; ENSOARP00000022393; ENSOARG00000020835.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; AAWPGWF; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR027164; IL-1_F10.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR10078:SF8; PTHR10078:SF8; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSOARP00000022393}.
SQ   SEQUENCE   157 AA;  17661 MW;  2F0359A3BED00878 CRC64;
     PLLVRMCSLP MAKYYIIKDA EQKALYVRDG QFLVGDPDAD NCHAETICIL PNRDLERTKF
     PIFLGVQGGS RCLACVETGE GPSLQLEDVN IEDLYKGGEE ATRFTFFQRS SGPAFRLEAA
     AWPGWFLSGS SEPQQPLRLT KESEPSARTE FYFEQSR
//
ID   W5QI43_SHEEP            Unreviewed;       156 AA.
AC   W5QI43;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 14.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000022394};
DE   Flags: Fragment;
GN   Name=IL36RN {ECO:0000313|Ensembl:ENSOARP00000022394};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022394, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022394, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022394}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000022394}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01077026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000022700; ENSOARP00000022394; ENSOARG00000020837.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; MKDSALK; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027171; IL-36RA.
DR   PANTHER; PTHR10078:SF7; PTHR10078:SF7; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSOARP00000022394}.
SQ   SEQUENCE   156 AA;  17204 MW;  4AD05D595B1A6326 CRC64;
     KMVLSGALCF RMKDAALKVL YLHDNQLLAG GLQAGKVIKG EEISVVPNRS LDAKLSPVIL
     GVQGGSQCLS CGTGQEPTLK LEPVNIMELY HSAEKSKKFT FYRRDTGLTS SFESAAYPGW
     FLCTVPEADQ PLQITQLPKD PSWDDPITDF YFQQCD
//
ID   W5QI50_SHEEP            Unreviewed;       154 AA.
AC   W5QI50;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000022401};
GN   Name=IL36B {ECO:0000313|Ensembl:ENSOARP00000022401};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022401, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022401, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022401}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000022401}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01077028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000022707; ENSOARP00000022401; ENSOARG00000020843.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; FQSVSYP; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027172; IL-36_beta.
DR   PANTHER; PTHR10078:SF24; PTHR10078:SF24; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   154 AA;  17512 MW;  22EB0E791D352A78 CRC64;
     MLQKYPSYRH IRDSRQMVWV VKGNSLIAVP SSNNVKPVIL SLIACRDMEF HEEGKGTPHY
     MGIKDKNLCL YCTEIQGYPT LQLKEEDIMN LYSKPRGEKH FLFHRSDEGS TVVFQSVSYP
     GWFIATSSEA GQPVTLTKER GTAKSTNYYL EGGL
//
ID   W5QI55_SHEEP            Unreviewed;       169 AA.
AC   W5QI55;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 12.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000022406};
DE   Flags: Fragment;
GN   Name=IL36A {ECO:0000313|Ensembl:ENSOARP00000022406};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022406, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022406, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022406}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000022406}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01077028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000022712; ENSOARP00000022406; ENSOARG00000020848.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; PGWFIAV; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR027163; IL-36_alpha.
DR   PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSOARP00000022406}.
SQ   SEQUENCE   169 AA;  18889 MW;  05FF9C33225B1F82 CRC64;
     SSKTPSSKGD GRIKVLSRVH PILVDIQDIN HLVWVLQGQT LTAVPRKDQM DPVTVTLISC
     KYTETLEKGR GNPVYLGLKE PELCLFCTKV EGQPTLQLQE RNIMDLYHQT EPVKPFLFYH
     DQNGRASSFE SVAFPGWFIG SCSNGGCPVI ITQELGKIYT TDFGFTVLQ
//
ID   W5QI56_SHEEP            Unreviewed;       120 AA.
AC   W5QI56;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 12.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000022407};
DE   Flags: Fragment;
GN   Name=IL36G {ECO:0000313|Ensembl:ENSOARP00000022407};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022407, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022407, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022407}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000022407}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01077029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000022713; ENSOARP00000022407; ENSOARG00000020850.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; TITILTC; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSOARP00000022407}.
SQ   SEQUENCE   120 AA;  13579 MW;  C7B65C3CEC9160CA CRC64;
     SYLTVTVTIM PCKYPESLEK GKGVPIYLGI KQPEMCLYCE DIGGKPTLQL KNQKILDLYN
     HAEPVKPFLF YHETTGRTST FESVAFPGWF IASSETNQPI FLTSELGNVY NTAFQLDFKV
//
ID   W5QI58_SHEEP            Unreviewed;       216 AA.
AC   W5QI58;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   08-JUN-2016, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000022409};
GN   Name=LOC105606425 {ECO:0000313|Ensembl:ENSOARP00000022409};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022409, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022409, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022409};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022409}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000022409}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01077031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000022715; ENSOARP00000022409; ENSOARG00000020852.
DR   GeneTree; ENSGT00530000062899; -.
DR   OMA; LPFTFLK; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   Pfam; PF00340; IL1; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   216 AA;  24193 MW;  3F21540C3D110B82 CRC64;
     MSSSEGSSDM KTDREFHEDE SESLPDLEAQ GALASDPSLS SVAPTHSGPR VKSVTFKKCN
     IRDRNQQVLV LEGGVLKAVP DKDVTARETF YISVSHRRVV KPMNEGKNHI FLAVSKGELC
     LYCDKVKRPK HPSLQLKKKH IKELSSLKAK DCLPFTFTKE QVGSYFTLES AANPGYFIYT
     SNKPGQPIGM TKELGQEKNI HFQFQETKME LDTVQD
//
ID   W5QI68_SHEEP            Unreviewed;       218 AA.
AC   W5QI68;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000022419};
GN   Name=IL37 {ECO:0000313|Ensembl:ENSOARP00000022419};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022419, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022419, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022419}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000022419}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01077034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004005955.1; XM_004005906.2.
DR   Ensembl; ENSOART00000022725; ENSOARP00000022419; ENSOARG00000020859.
DR   GeneID; 101111617; -.
DR   KEGG; oas:101111617; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   KO; K05485; -.
DR   OMA; RKHTEFS; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR027169; IL-37.
DR   PANTHER; PTHR10078:SF9; PTHR10078:SF9; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   218 AA;  24586 MW;  CE8DED617C2ABF7F CRC64;
     MSVLEENPGM KMDCEDWERY EPQCSSEDPD RDALEPGPSL TSVSSAHAGP RVKPKGPEKF
     IIHDRDQKVL VLDSKILRAV PDRTYIVPEI FFVLASRVMS AHENKGSPIL LAVSKGELCL
     YCDKNKGHNK PSLQLKKKKL STLAAQEKGK CLPYIFYRNK VSSRNTVESA AHPGWFICTF
     RYPGKPVGMT KCHGERKHTE FSFRQIYEAE TSPSEVSE
//
ID   W5QI89_SHEEP            Unreviewed;       309 AA.
AC   W5QI89;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   11-MAY-2016, entry version 18.
DE   SubName: Full=Interleukin-1 alpha {ECO:0000313|Ensembl:ENSOARP00000022441};
GN   Name=IL1A {ECO:0000313|Ensembl:ENSOARP00000022441};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022441, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022441, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022441}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|RuleBase:RU003752, ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000022441}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01077037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012015192.1; XM_012159802.2.
DR   UniGene; Oar.433; -.
DR   Ensembl; ENSOART00000022747; ENSOARP00000022441; ENSOARG00000020877.
DR   GeneID; 443404; -.
DR   CTD; 3552; -.
DR   GeneTree; ENSGT00390000013353; -.
DR   OMA; NQKSFYD; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0001660; P:fever generation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR003294; IL-1_alpha/beta.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Cytokine {ECO:0000256|RuleBase:RU003753,
KW   ECO:0000256|SAAS:SAAS00482533};
KW   Inflammatory response {ECO:0000256|RuleBase:RU003753};
KW   Mitogen {ECO:0000256|RuleBase:RU003753};
KW   Pyrogen {ECO:0000256|RuleBase:RU003753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
FT   DOMAIN       42    150       IL1_propep. {ECO:0000259|Pfam:PF02394}.
SQ   SEQUENCE   309 AA;  35410 MW;  2F2DB6280E10A841 CRC64;
     MATPTPKQTK GEGAWLSSSL RAKTREPVIS LLPARFSKEV KMAKVPDLFE DLKNCYSENE
     DYSSEIDHLS LNQKSFYDAS YEPLREDHMN KFMSLDTSET SKTSRLSFKE NVVMMTANGK
     ILKKRRLSLN QFITDDDLEA IANDTEEEII KPRSAHYSFQ SNVKYNFMRV IHQECILNDA
     LNQSIIRDMS GPYLTAATLN NLEEAVKFDM VAYVSEEDSQ LPVTLRISKT QLFVSAQNED
     EPVLLKEMPE TPKIIKDETN LLFFWEKHGS MDYFKSVAHP KLFIATKQEK LVHMASGPPS
     ITDFQILEK
//
ID   Z4YNI9_RAT              Unreviewed;       194 AA.
AC   Z4YNI9;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 2.
DT   06-JUL-2016, entry version 17.
DE   SubName: Full=Interleukin-18 {ECO:0000313|Ensembl:ENSRNOP00000013093};
GN   Name=Il18 {ECO:0000313|Ensembl:ENSRNOP00000013093,
GN   ECO:0000313|RGD:2889};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000013093, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000013093, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000013093,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000013093}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000013093};
RG   Ensembl;
RL   Submitted (APR-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562089}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|SAAS:SAAS00562072}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000013093}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AC141541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10116.ENSRNOP00000013093; -.
DR   PaxDb; Z4YNI9; -.
DR   Ensembl; ENSRNOT00000013093; ENSRNOP00000013093; ENSRNOG00000009848.
DR   RGD; 2889; Il18.
DR   eggNOG; ENOG410J3U9; Eukaryota.
DR   eggNOG; ENOG410ZGS8; LUCA.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; PVFEDMP; -.
DR   Reactome; R-RNO-448706; Interleukin-1 processing.
DR   Reactome; R-RNO-449147; Signaling by Interleukins.
DR   Proteomes; UP000002494; Chromosome 8.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0042088; P:T-helper 1 type immune response; IEA:Ensembl.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   PANTHER; PTHR11326; PTHR11326; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytokine {ECO:0000256|SAAS:SAAS00482533};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Z4YNI9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|SAAS:SAAS00449276}.
SQ   SEQUENCE   194 AA;  22313 MW;  4957D7F9B0C35595 CRC64;
     MAAIPEEGSC VNFKEMMFID NTLYLIPEDN GDLESDHFGR LHCTTAVMRS INDQVLFVDK
     RNPPVFEDMP DIDRTANESQ TRLIIYMYKD SEVRGLAVTL SVKDGRMSTL SCKNKIISFE
     EMNPPENIDD IKSDLIFFQK RVPGHNKMEF ESSLYEGHFL ACQKEDDAFK LVLKRKDENG
     DKSVMFTLTN LHQS
//