ID   6PGL_HUMAN              Reviewed;         258 AA.
AC   O95336;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   19-FEB-2014, entry version 116.
DE   RecName: Full=6-phosphogluconolactonase;
DE            Short=6PGL;
DE            EC=3.1.1.31;
GN   Name=PGLS;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10518023; DOI=10.1016/S0014-5793(99)01247-8;
RA   Collard F., Collet J.-F., Gerin I., Veiga-da-Cunha M.,
RA   van Schaftingen E.;
RT   "Identification of the cDNA encoding human 6-phosphogluconolactonase,
RT   the enzyme catalyzing the second step of the pentose phosphate
RT   pathway.";
RL   FEBS Lett. 459:223-226(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 41-72 AND 82-96, AND MASS SPECTROMETRY.
RC   TISSUE=Brain, Cajal-Retzius cell, and Fetal brain cortex;
RA   Lubec G., Vishwanath V., Chen W.-Q., Sun Y.;
RL   Submitted (DEC-2008) to UniProtKB.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-242.
RA   Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F.;
RT   "Full-insert sequence of mapped XREF EST.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY, AND
RP   CLEAVAGE OF INITIATOR METHIONINE.
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA   Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT   a refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [6]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-180, AND MASS SPECTROMETRY.
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA   Walther T.C., Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-
CC       phosphogluconate.
CC   -!- CATALYTIC ACTIVITY: 6-phospho-D-glucono-1,5-lactone + H(2)O = 6-
CC       phospho-D-gluconate.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 2/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC72960.1; Type=Erroneous initiation;
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DR   EMBL; AJ243972; CAB57866.1; -; mRNA.
DR   EMBL; BC014006; AAH14006.1; -; mRNA.
DR   EMBL; AF091091; AAC72960.1; ALT_INIT; mRNA.
DR   RefSeq; NP_036220.1; NM_012088.2.
DR   UniGene; Hs.466165; -.
DR   ProteinModelPortal; O95336; -.
DR   SMR; O95336; 38-247.
DR   BioGrid; 117328; 8.
DR   MINT; MINT-5000838; -.
DR   STRING; 9606.ENSP00000252603; -.
DR   PhosphoSite; O95336; -.
DR   OGP; O95336; -.
DR   REPRODUCTION-2DPAGE; IPI00029997; -.
DR   PaxDb; O95336; -.
DR   PeptideAtlas; O95336; -.
DR   PRIDE; O95336; -.
DR   DNASU; 25796; -.
DR   Ensembl; ENST00000252603; ENSP00000252603; ENSG00000130313.
DR   GeneID; 25796; -.
DR   KEGG; hsa:25796; -.
DR   UCSC; uc002ngw.3; human.
DR   CTD; 25796; -.
DR   GeneCards; GC19P017622; -.
DR   HGNC; HGNC:8903; PGLS.
DR   HPA; HPA040744; -.
DR   HPA; HPA042032; -.
DR   MIM; 604951; gene.
DR   neXtProt; NX_O95336; -.
DR   PharmGKB; PA33240; -.
DR   eggNOG; COG0363; -.
DR   HOGENOM; HOG000256285; -.
DR   HOVERGEN; HBG000030; -.
DR   InParanoid; O95336; -.
DR   KO; K01057; -.
DR   OMA; TYGLYKS; -.
DR   OrthoDB; EOG7RZ5QV; -.
DR   PhylomeDB; O95336; -.
DR   TreeFam; TF318609; -.
DR   BRENDA; 3.1.1.31; 2681.
DR   Reactome; REACT_111217; Metabolism.
DR   UniPathway; UPA00115; UER00409.
DR   GenomeRNAi; 25796; -.
DR   NextBio; 46981; -.
DR   PRO; PR:O95336; -.
DR   ArrayExpress; O95336; -.
DR   Bgee; O95336; -.
DR   CleanEx; HS_PGLS; -.
DR   Genevestigator; O95336; -.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IDA:UniProtKB.
DR   GO; GO:0048029; F:monosaccharide binding; IEA:Ensembl.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IDA:UniProtKB.
DR   GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IEA:Ensembl.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   TIGRFAMs; TIGR01198; pgl; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing;
KW   Hydrolase; Reference proteome.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    258       6-phosphogluconolactonase.
FT                                /FTId=PRO_0000090078.
FT   MOD_RES       2      2       N-acetylalanine.
FT   MOD_RES     180    180       N6-acetyllysine.
SQ   SEQUENCE   258 AA;  27547 MW;  A753FB7E662116DD CRC64;
     MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL VSMLARELPA
     AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL SRLPIPESQV ITINPELPVE
     EAAEDYAKKL RQAFQGDSIP VFDLLILGVG PDGHTCSLFP DHPLLQEREK IVAPISDSPK
     PPPQRVTLTL PVLNAARTVI FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL
     DEAAARLLTV PFEKHSTL
//