PMID- 103000 OWN - NLM STAT- MEDLINE DA - 19790223 DCOM- 19790223 LR - 20061115 IS - 0028-0836 (Print) IS - 0028-0836 (Linking) VI - 276 IP - 5688 DP - 1978 Dec 7 TI - A gene complex controlling segmentation in Drosophila. PG - 565-70 AB - The bithorax gene complex in Drosophila contains a minimum of eight genes that seem to code for substances controlling levels of thoracic and abdominal development. The state of repression of at least four of these genes is controlled by cis-regulatory elements and a separate locus (Polycomb) seems to code for a repressor of the complex. The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element. FAU - Lewis, E B AU - Lewis EB LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - ENGLAND TA - Nature JT - Nature JID - 0410462 SB - IM MH - Abdomen/anatomy & histology/growth & development MH - Animals MH - Chromosome Mapping MH - Drosophila melanogaster/*genetics/growth & development MH - Genes, Regulator MH - Mutation MH - Thorax/anatomy & histology/growth & development EDAT- 1978/12/07 MHDA- 1978/12/07 00:01 CRDT- 1978/12/07 00:00 PST - ppublish SO - Nature. 1978 Dec 7;276(5688):565-70.