{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P18031","features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"Tyrosine-protein phosphatase non-receptor type 1","featureId":"PRO_0000094748"},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2546149"}]},{"type":"Modified residue","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"15592455"}]},{"type":"Modified residue","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Phosphoserine; by PKB/AKT1, CLK1 and CLK2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10480872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11579209"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Phosphotyrosine; by EGFR","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9355745"}]},{"type":"Modified residue","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Cysteine persulfide; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22169477"}]},{"type":"Modified residue","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Cysteine sulfenic acid (-SOH); alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12802338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12802339"}]},{"type":"Modified residue","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Cysteine sulfinic acid (-SO2H); alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12802339"}]},{"type":"Modified residue","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"S-nitrosocysteine; in reversibly inhibited form","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22169477"}]},{"type":"Modified residue","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Phosphoserine; by CLK1 and CLK2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10480872"}]},{"type":"Modified residue","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Phosphoserine; by CLK1 and CLK2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10480872"}]},{"type":"Modified residue","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8491187"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8491187"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"Phosphoserine; by CDK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8491187"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Cross-link","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"N,N-(cysteine-1,S-diyl)serine (Cys-Ser); in inhibited form","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12802338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12802339"}]}],"extraAttributes":{"uniParcId":"UPI000011DD79"}}