load =1Dfm

define sugar_o (*.O?' and dna)
define sugar_c (*.C?' and dna)
define phos_o (*.OP? and dna)
define phos_p (*.P and dna)
define base_o (*.O? and dna)
define base_n (*.N? and dna)
define base_c (*.C? and dna)

define A_major ((A.C5 or A.C6 or A.N6 or A.N7) and dna )
define A_minor ((A.C2 or A.C4 or A.N3) and dna)

define C_major ((C.C4 or C.C5 or C.C6 or C.N4) and dna)
define C_minor ((C.C2 or C.O2) and dna)

define G_major ((G.C5 or G.C6 or G.C8 or G.N7 or G.O6) and dna)
define G_minor ((G.C2 or G.C4 or G.N2 or G.N3) and dna)

define T_major ((T.C4 or T.C5 or T.C5M or T.O4) and dna)
define T_minor ((T.C2 or T.C6 or T.O2) and dna)

define dna_major (A_major or C_major or G_major or T_major)
define dna_minor (A_minor or C_minor or G_minor or T_minor)

define polar_major (dna_major and (base_o or base_n))
define polar_minor (dna_minor and (base_o or base_n))
define non_polar_major (dna_major and base_c)
define non_polar_minor (dna_minor and base_c)

define polar_protein ((*.N? and protein) or (*.O? and protein))
define non_polar_protein ((*.C? and protein) or (*.S? and protein) or (*.P? and protein))

select (within(3.5, sugar_o) and polar_protein)
select (within(4.5, sugar_c) and non_polar_protein)
select (within(3.5, phos_o) and polar_protein)
select (within(4.5, phos_p) and non_polar_protein)
select (within(3.5, polar_major) and polar_protein) 
select (within(4.5, non_polar_major) and non_polar_protein)
select (within(3.5, polar_minor) and polar_protein) 
select (within(4.5, non_polar_minor) and non_polar_protein)