ID   PANK_YEAST              Reviewed;         367 AA.
AC   Q04430;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   15-JAN-2008, entry version 46.
DE   Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase).
GN   OrderedLocusNames=YDR531W;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   MEDLINE=97313263; PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N.,
RA   Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M.,
RA   Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L.,
RA   Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M.,
RA   Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S.,
RA   Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M.,
RA   Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S.,
RA   Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K.,
RA   Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D.,
RA   Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C.,
RA   Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T.,
RA   Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W.,
RA   Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K.,
RA   Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S.,
RA   Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A.,
RA   Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S.,
RA   Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M.,
RA   Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y.,
RA   Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M.,
RA   Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E.,
RA   Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R.,
RA   Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   MEDLINE=22923954; PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [3]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   MEDLINE=22923965; PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA   Dephoure N., O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Plays a role in the physiological regulation of the
CC       intracellular CoA concentration (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'-
CC       phosphopantothenate.
CC   -!- ENZYME REGULATION: Regulated by feedback inhibition by malonyl-CoA
CC       (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme
CC       A from pantothenate: step 1/5.
CC   -!- INTERACTION:
CC       P10592:SSA2; NbExp=1; IntAct=EBI-35891, EBI-8603;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- MISCELLANEOUS: Present with 6190 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the type II pantothenate kinase family.
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DR   EMBL; U33057; AAB64970.1; -; Genomic_DNA.
DR   PIR; S69586; S69586.
DR   RefSeq; NP_010820.1; -.
DR   DIP; DIP:5375N; -.
DR   IntAct; Q04430; -.
DR   Ensembl; YDR531W; Saccharomyces cerevisiae.
DR   GeneID; 852144; -.
DR   GenomeReviews; Z71256_GR; YDR531W.
DR   KEGG; sce:YDR531W; -.
DR   CYGD; YDR531w; -.
DR   SGD; S000002939; YDR531W.
DR   LinkHub; Q04430; -.
DR   GermOnline; YDR531W; Saccharomyces cerevisiae.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   InterPro; IPR011602; Fumble.
DR   InterPro; IPR014454; PanK.
DR   InterPro; IPR004567; PanK_eukar.
DR   Pfam; PF03630; Fumble; 1.
DR   PIRSF; PIRSF009355; PanK; 1.
DR   TIGRFAMs; TIGR00555; panK_eukar; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Nucleus; Transferase.
FT   CHAIN         1    367       Pantothenate kinase.
FT                                /FTId=PRO_0000253828.
SQ   SEQUENCE   367 AA;  40903 MW;  E87F23FFAA08E2AA CRC64;
     MPRITQEISY NCDYGDNTFN LAIDIGGTLA KVVFSPIHSN RLMFYTIETE KIDKFMELLH
     SIIKEHNNGC YRMTHIIATG GGAFKFYDLL YENFPQIKGI SRFEEMEGLI HGLDFFIHEI
     PDEVFTYNDQ DGERIIPTSS GTMDSKAIYP YLLVNIGSGV SILKVTEPNN FSRVGGSSLG
     GGTLWGLLSL ITGAQTYDQM LDWAQEGDNS SVDMLVGDIY GTDYNKIGLK SSAIASSFGK
     VFQNRMTSNK SLENNENKLY SSHESIEKNN GQMFKNPDIC KSLLFAISNN IGQIAYLQAK
     INNIQNIYFG GSYTRGHLTT MNTLSYAINF WSQGSKQAFF LKHEGYLGAM GAFLSASRHS
     STKKTST
//