Analysis Type: PANTHER Overrepresentation Test (Released 20240807) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.14861039 Released 2025-02-06 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO molecular function complete Homo sapiens - REFLIST (20580) upload_1 (6) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) estradiol 17-beta-dehydrogenase [NAD(P)+] activity (GO:0004303) 19 5 .01 + > 100 2.27E-15 1.16E-11 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0033764) 32 5 .01 + > 100 3.93E-14 1.00E-10 steroid dehydrogenase activity (GO:0016229) 35 5 .01 + > 100 6.33E-14 1.08E-10 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616) 122 5 .04 + > 100 4.03E-11 5.13E-08 oxidoreductase activity, acting on CH-OH group of donors (GO:0016614) 132 5 .04 + > 100 6.00E-11 6.12E-08 oxidoreductase activity (GO:0016491) 728 6 .21 + 28.27 1.92E-09 1.63E-06 testosterone dehydrogenase [NAD(P)+] activity (GO:0030283) 13 3 .00 + > 100 3.93E-09 2.86E-06 testosterone dehydrogenase (NAD+) activity (GO:0047035) 8 2 .00 + > 100 1.98E-06 1.12E-03 17-beta-hydroxysteroid dehydrogenase (NADP+) activity (GO:0072582) 9 2 .00 + > 100 2.55E-06 1.18E-03 testosterone 17-beta-dehydrogenase (NADP+) activity (GO:0047045) 8 2 .00 + > 100 1.98E-06 1.26E-03 17-beta-hydroxysteroid dehydrogenase (NAD+) activity (GO:0044594) 9 2 .00 + > 100 2.55E-06 1.30E-03 D-threo-aldose 1-dehydrogenase activity (GO:0047834) 1 1 .00 + > 100 2.92E-04 1.06E-01 farnesol dehydrogenase activity (GO:0047886) 1 1 .00 + > 100 2.92E-04 1.14E-01 estradiol binding (GO:1903924) 1 1 .00 + > 100 2.92E-04 1.24E-01 catalytic activity (GO:0003824) 5586 6 1.63 + 3.68 3.99E-04 1.36E-01 aromatase activity (GO:0070330) 2 1 .00 + > 100 5.83E-04 1.75E-01 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity (GO:0047006) 2 1 .00 + > 100 5.83E-04 1.86E-01 NADP+ binding (GO:0070401) 3 1 .00 + > 100 8.74E-04 2.48E-01 allyl-alcohol dehydrogenase activity (GO:0047655) 4 1 .00 + > 100 1.17E-03 3.13E-01 estrogen 2-hydroxylase activity (GO:0101021) 9 1 .00 + > 100 2.62E-03 6.68E-01 aldose reductase (NADPH) activity (GO:0004032) 12 1 .00 + > 100 3.49E-03 8.48E-01 all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650) 13 1 .00 + > 100 3.78E-03 8.77E-01 growth hormone receptor binding (GO:0005131) 10 0 .00 - < 0.01 1.00E00 1.00E00 granulocyte colony-stimulating factor receptor binding (GO:0005130) 1 0 .00 - < 0.01 1.00E00 1.00E00 14-3-3 protein binding (GO:0071889) 33 0 .01 - < 0.01 1.00E00 1.00E00 neuromedin U binding (GO:0042924) 2 0 .00 - < 0.01 1.00E00 1.00E00 neuropeptide binding (GO:0042923) 33 0 .01 - < 0.01 1.00E00 1.00E00 neuromedin U receptor binding (GO:0042922) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding (GO:0071886) 2 0 .00 - < 0.01 1.00E00 1.00E00 N-terminal protein N-methyltransferase activity (GO:0071885) 2 0 .00 - < 0.01 1.00E00 1.00E00 granulocyte macrophage colony-stimulating factor receptor binding (GO:0005129) 1 0 .00 - < 0.01 1.00E00 1.00E00 erythropoietin receptor binding (GO:0005128) 3 0 .00 - < 0.01 1.00E00 1.00E00 ciliary neurotrophic factor receptor binding (GO:0005127) 6 0 .00 - < 0.01 1.00E00 1.00E00 cytokine receptor binding (GO:0005126) 274 0 .08 - < 0.01 1.00E00 1.00E00 cytokine activity (GO:0005125) 237 0 .07 - < 0.01 1.00E00 1.00E00 scavenger receptor binding (GO:0005124) 4 0 .00 - < 0.01 1.00E00 1.00E00 death receptor binding (GO:0005123) 21 0 .01 - < 0.01 1.00E00 1.00E00 Toll binding (GO:0005121) 1 0 .00 - < 0.01 1.00E00 1.00E00 lactosylceramide 4-alpha-galactosyltransferase activity (GO:0050512) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity (GO:0050510) 4 0 .00 - < 0.01 1.00E00 1.00E00 xenobiotic transmembrane transporter activity (GO:0042910) 32 0 .01 - < 0.01 1.00E00 1.00E00 inositol trisphosphate phosphatase activity (GO:0046030) 14 0 .00 - < 0.01 1.00E00 1.00E00 smoothened binding (GO:0005119) 4 0 .00 - < 0.01 1.00E00 1.00E00 Tat protein binding (GO:0030957) 10 0 .00 - < 0.01 1.00E00 1.00E00 potassium ion binding (GO:0030955) 13 0 .00 - < 0.01 1.00E00 1.00E00 receptor tyrosine kinase-like orphan receptor binding (GO:0005115) 1 0 .00 - < 0.01 1.00E00 1.00E00 type II transforming growth factor beta receptor binding (GO:0005114) 11 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity (GO:0050509) 2 0 .00 - < 0.01 1.00E00 1.00E00 patched binding (GO:0005113) 8 0 .00 - < 0.01 1.00E00 1.00E00 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (GO:0050508) 3 0 .00 - < 0.01 1.00E00 1.00E00 Notch binding (GO:0005112) 26 0 .01 - < 0.01 1.00E00 1.00E00 type 2 fibroblast growth factor receptor binding (GO:0005111) 5 0 .00 - < 0.01 1.00E00 1.00E00 hyaluronan synthase activity (GO:0050501) 3 0 .00 - < 0.01 1.00E00 1.00E00 tubulin deacetylase activity (GO:0042903) 2 0 .00 - < 0.01 1.00E00 1.00E00 phospholipid:diacylglycerol acyltransferase activity (GO:0046027) 1 0 .00 - < 0.01 1.00E00 1.00E00 frizzled binding (GO:0005109) 39 0 .01 - < 0.01 1.00E00 1.00E00 protein tyrosine phosphatase activity, metal-dependent (GO:0030946) 88 0 .03 - < 0.01 1.00E00 1.00E00 type 1 fibroblast growth factor receptor binding (GO:0005105) 6 0 .00 - < 0.01 1.00E00 1.00E00 mitochondrion targeting sequence binding (GO:0030943) 6 0 .00 - < 0.01 1.00E00 1.00E00 fibroblast growth factor receptor binding (GO:0005104) 27 0 .01 - < 0.01 1.00E00 1.00E00 endoplasmic reticulum signal peptide binding (GO:0030942) 3 0 .00 - < 0.01 1.00E00 1.00E00 signaling receptor binding (GO:0005102) 1545 0 .45 - < 0.01 1.00E00 1.00E00 glycerol-3-phosphate dehydrogenase (NAD+) activity (GO:0141152) 2 0 .00 - < 0.01 1.00E00 1.00E00 5'-3' RNA polymerase activity (GO:0034062) 32 0 .01 - < 0.01 1.00E00 1.00E00 DNA polymerase activity (GO:0034061) 40 0 .01 - < 0.01 1.00E00 1.00E00 neuropeptide receptor binding (GO:0071855) 41 0 .01 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on peroxide as acceptor (GO:0016684) 58 0 .02 - < 0.01 1.00E00 1.00E00 enoyl-[acyl-carrier-protein] reductase (NADPH) activity (GO:0141148) 2 0 .00 - < 0.01 1.00E00 1.00E00 intracellularly calcium-gated channel activity (GO:0141147) 19 0 .01 - < 0.01 1.00E00 1.00E00 RNA strand-exchange activity (GO:0034057) 2 0 .00 - < 0.01 1.00E00 1.00E00 estrogen response element binding (GO:0034056) 11 0 .00 - < 0.01 1.00E00 1.00E00 benzoate-CoA ligase activity (GO:0018858) 3 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on diphenols and related substances as donors (GO:0016679) 9 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on a heme group of donors (GO:0016675) 14 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor (GO:0016672) 3 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor (GO:0016671) 9 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor (GO:0016670) 11 0 .00 - < 0.01 1.00E00 1.00E00 XTP diphosphatase activity (GO:0036222) 1 0 .00 - < 0.01 1.00E00 1.00E00 UTP diphosphatase activity (GO:0036221) 3 0 .00 - < 0.01 1.00E00 1.00E00 ITP diphosphatase activity (GO:0036220) 1 0 .00 - < 0.01 1.00E00 1.00E00 poly(G) binding (GO:0034046) 8 0 .00 - < 0.01 1.00E00 1.00E00 diphthine methyl ester synthase activity (GO:0141133) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA N6-methyladenine demethylase activity (GO:0141131) 2 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type sterol transporter activity (GO:0034041) 2 0 .00 - < 0.01 1.00E00 1.00E00 ATPase-coupled lipid transmembrane transporter activity (GO:0034040) 9 0 .00 - < 0.01 1.00E00 1.00E00 HMG box domain binding (GO:0071837) 13 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor (GO:0016668) 11 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on a sulfur group of donors (GO:0016667) 55 0 .02 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor (GO:0016662) 4 0 .00 - < 0.01 1.00E00 1.00E00 GTP diphosphatase activity (GO:0036219) 2 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on other nitrogenous compounds as donors (GO:0016661) 12 0 .00 - < 0.01 1.00E00 1.00E00 dTTP diphosphatase activity (GO:0036218) 1 0 .00 - < 0.01 1.00E00 1.00E00 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity (GO:0034039) 2 0 .00 - < 0.01 1.00E00 1.00E00 short-chain fatty acyl-CoA hydrolase activity (GO:0141126) 1 0 .00 - < 0.01 1.00E00 1.00E00 deoxyhypusine synthase activity (GO:0034038) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-queuosine(34) galactosyltransferase activity (GO:0141125) 1 0 .00 - < 0.01 1.00E00 1.00E00 TPR domain binding (GO:0030911) 7 0 .00 - < 0.01 1.00E00 1.00E00 N-box binding (GO:0071820) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655) 58 0 .02 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor (GO:0016653) 11 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on NAD(P)H as acceptor (GO:0016652) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on NAD(P)H (GO:0016651) 89 0 .03 - < 0.01 1.00E00 1.00E00 nitric oxide dioxygenase activity, heme protein as donor (GO:0141118) 1 0 .00 - < 0.01 1.00E00 1.00E00 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (GO:0004699) 15 0 .00 - < 0.01 1.00E00 1.00E00 calcium,diacylglycerol-dependent serine/threonine kinase activity (GO:0004698) 15 0 .00 - < 0.01 1.00E00 1.00E00 transporter inhibitor activity (GO:0141110) 45 0 .01 - < 0.01 1.00E00 1.00E00 diacylglycerol-dependent serine/threonine kinase activity (GO:0004697) 16 0 .00 - < 0.01 1.00E00 1.00E00 eukaryotic translation initiation factor 2alpha kinase activity (GO:0004694) 244 0 .07 - < 0.01 1.00E00 1.00E00 cyclin-dependent protein serine/threonine kinase activity (GO:0004693) 29 0 .01 - < 0.01 1.00E00 1.00E00 cGMP-dependent protein kinase activity (GO:0004692) 2 0 .00 - < 0.01 1.00E00 1.00E00 cAMP-dependent protein kinase activity (GO:0004691) 7 0 .00 - < 0.01 1.00E00 1.00E00 cyclic nucleotide-dependent protein kinase activity (GO:0004690) 9 0 .00 - < 0.01 1.00E00 1.00E00 protein-lipid complex binding (GO:0071814) 30 0 .01 - < 0.01 1.00E00 1.00E00 Delta4-3-oxosteroid 5beta-reductase activity (GO:0047787) 2 0 .00 - < 0.01 1.00E00 1.00E00 lipoprotein particle binding (GO:0071813) 30 0 .01 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor (GO:0016649) 4 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor (GO:0016647) 3 0 .00 - < 0.01 1.00E00 1.00E00 cyanamide hydratase activity (GO:0018820) 2 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646) 17 0 .00 - < 0.01 1.00E00 1.00E00 corticosterone 18-monooxygenase activity (GO:0047783) 2 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-NH group of donors (GO:0016645) 26 0 .01 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor (GO:0016642) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor (GO:0016641) 16 0 .00 - < 0.01 1.00E00 1.00E00 transporter activator activity (GO:0141109) 14 0 .00 - < 0.01 1.00E00 1.00E00 transporter regulator activity (GO:0141108) 174 0 .05 - < 0.01 1.00E00 1.00E00 methyltransferase regulator activity (GO:0141107) 3 0 .00 - < 0.01 1.00E00 1.00E00 tRNA methyltransferase activator activity (GO:0141106) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphorylase kinase activity (GO:0004689) 4 0 .00 - < 0.01 1.00E00 1.00E00 tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity (GO:0141101) 1 0 .00 - < 0.01 1.00E00 1.00E00 myosin light chain kinase activity (GO:0004687) 4 0 .00 - < 0.01 1.00E00 1.00E00 FAD-AMP lyase (cyclizing) activity (GO:0034012) 1 0 .00 - < 0.01 1.00E00 1.00E00 elongation factor-2 kinase activity (GO:0004686) 1 0 .00 - < 0.01 1.00E00 1.00E00 microtubule destabilizing activity (GO:0170060) 9 0 .00 - < 0.01 1.00E00 1.00E00 calcium/calmodulin-dependent protein kinase activity (GO:0004683) 27 0 .01 - < 0.01 1.00E00 1.00E00 (S)-citramalyl-CoA lyase activity (GO:0047777) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor (GO:0016639) 2 0 .00 - < 0.01 1.00E00 1.00E00 3-hydroxyacyl-CoA dehydratase activity (GO:0018812) 8 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-NH2 group of donors (GO:0016638) 20 0 .01 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor (GO:0016635) 5 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor (GO:0016634) 9 0 .00 - < 0.01 1.00E00 1.00E00 enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) (GO:0016631) 2 0 .00 - < 0.01 1.00E00 1.00E00 RNA ligase (GTP) activity (GO:0170057) 1 0 .00 - < 0.01 1.00E00 1.00E00 AMP-activated protein kinase activity (GO:0004679) 247 0 .07 - < 0.01 1.00E00 1.00E00 lipid transmembrane transporter activity (GO:0170055) 56 0 .02 - < 0.01 1.00E00 1.00E00 ribonuclease activator activity (GO:0170054) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-dependent protein kinase activity (GO:0004677) 245 0 .07 - < 0.01 1.00E00 1.00E00 nuclease activator activity (GO:0170053) 1 0 .00 - < 0.01 1.00E00 1.00E00 3-phosphoinositide-dependent protein kinase activity (GO:0004676) 244 0 .07 - < 0.01 1.00E00 1.00E00 transmembrane receptor protein serine/threonine kinase activity (GO:0004675) 18 0 .01 - < 0.01 1.00E00 1.00E00 protein serine/threonine kinase activity (GO:0004674) 430 0 .13 - < 0.01 1.00E00 1.00E00 protein histidine kinase activity (GO:0004673) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein kinase activity (GO:0004672) 563 0 .16 - < 0.01 1.00E00 1.00E00 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity (GO:0004671) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor (GO:0016628) 33 0 .01 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) 60 0 .02 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624) 8 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor (GO:0016623) 4 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620) 40 0 .01 - < 0.01 1.00E00 1.00E00 protein-arginine deiminase activity (GO:0004668) 5 0 .00 - < 0.01 1.00E00 1.00E00 prostaglandin-D synthase activity (GO:0004667) 3 0 .00 - < 0.01 1.00E00 1.00E00 prostaglandin-endoperoxide synthase activity (GO:0004666) 3 0 .00 - < 0.01 1.00E00 1.00E00 Rab geranylgeranyltransferase activity (GO:0004663) 5 0 .00 - < 0.01 1.00E00 1.00E00 CAAX-protein geranylgeranyltransferase activity (GO:0004662) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein geranylgeranyltransferase activity (GO:0004661) 6 0 .00 - < 0.01 1.00E00 1.00E00 protein farnesyltransferase activity (GO:0004660) 2 0 .00 - < 0.01 1.00E00 1.00E00 chondroitin-glucuronate 5-epimerase activity (GO:0047757) 2 0 .00 - < 0.01 1.00E00 1.00E00 chondroitin 4-sulfotransferase activity (GO:0047756) 4 0 .00 - < 0.01 1.00E00 1.00E00 hydroxypyruvate reductase [NAD(P)H] activity (GO:0016618) 1 0 .00 - < 0.01 1.00E00 1.00E00 4-oxoproline reductase activity (GO:0016617) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA 5'-gamma-phosphate methyltransferase activity (GO:1990276) 1 0 .00 - < 0.01 1.00E00 1.00E00 malate dehydrogenase activity (GO:0016615) 8 0 .00 - < 0.01 1.00E00 1.00E00 preribosome binding (GO:1990275) 8 0 .00 - < 0.01 1.00E00 1.00E00 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity (GO:0047751) 3 0 .00 - < 0.01 1.00E00 1.00E00 cholestenol delta-isomerase activity (GO:0047750) 2 0 .00 - < 0.01 1.00E00 1.00E00 anti-Mullerian hormone receptor activity (GO:1990272) 1 0 .00 - < 0.01 1.00E00 1.00E00 HLH domain binding (GO:0043398) 3 0 .00 - < 0.01 1.00E00 1.00E00 heparan sulfate proteoglycan binding (GO:0043395) 19 0 .01 - < 0.01 1.00E00 1.00E00 proteoglycan binding (GO:0043394) 37 0 .01 - < 0.01 1.00E00 1.00E00 2-alkenal reductase (NADPH) activity (GO:0035798) 1 0 .00 - < 0.01 1.00E00 1.00E00 prenyltransferase activity (GO:0004659) 17 0 .00 - < 0.01 1.00E00 1.00E00 propionyl-CoA carboxylase activity (GO:0004658) 2 0 .00 - < 0.01 1.00E00 1.00E00 proline dehydrogenase activity (GO:0004657) 2 0 .00 - < 0.01 1.00E00 1.00E00 procollagen-proline 4-dioxygenase activity (GO:0004656) 5 0 .00 - < 0.01 1.00E00 1.00E00 porphobilinogen synthase activity (GO:0004655) 1 0 .00 - < 0.01 1.00E00 1.00E00 polyribonucleotide nucleotidyltransferase activity (GO:0004654) 1 0 .00 - < 0.01 1.00E00 1.00E00 polypeptide N-acetylgalactosaminyltransferase activity (GO:0004653) 19 0 .01 - < 0.01 1.00E00 1.00E00 polynucleotide 5'-phosphatase activity (GO:0004651) 2 0 .00 - < 0.01 1.00E00 1.00E00 cholestanetetraol 26-dehydrogenase activity (GO:0047748) 1 0 .00 - < 0.01 1.00E00 1.00E00 cholate-CoA ligase activity (GO:0047747) 2 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II C-terminal domain phosphoserine binding (GO:1990269) 4 0 .00 - < 0.01 1.00E00 1.00E00 growth hormone-releasing hormone activity (GO:0016608) 2 0 .00 - < 0.01 1.00E00 1.00E00 endopolyphosphatase activity (GO:0000298) 5 0 .00 - < 0.01 1.00E00 1.00E00 chlordecone reductase activity (GO:0047743) 1 0 .00 - < 0.01 1.00E00 1.00E00 TRAIL binding (GO:0045569) 5 0 .00 - < 0.01 1.00E00 1.00E00 adenine nucleotide transmembrane transporter activity (GO:0000295) 23 0 .01 - < 0.01 1.00E00 1.00E00 glutaminyl-peptide cyclotransferase activity (GO:0016603) 2 0 .00 - < 0.01 1.00E00 1.00E00 ferric-chelate reductase activity (GO:0000293) 3 0 .00 - < 0.01 1.00E00 1.00E00 poly(ADP-ribose) glycohydrolase activity (GO:0004649) 2 0 .00 - < 0.01 1.00E00 1.00E00 O-phospho-L-serine:2-oxoglutarate aminotransferase activity (GO:0004648) 1 0 .00 - < 0.01 1.00E00 1.00E00 cyclic GMP-AMP synthase activity (GO:0140699) 1 0 .00 - < 0.01 1.00E00 1.00E00 1,4-alpha-oligoglucan phosphorylase activity (GO:0004645) 5 0 .00 - < 0.01 1.00E00 1.00E00 phosphoribosylglycinamide formyltransferase activity (GO:0004644) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphoribosylaminoimidazolecarboxamide formyltransferase activity (GO:0004643) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphoribosylformylglycinamidine synthase activity (GO:0004642) 1 0 .00 - < 0.01 1.00E00 1.00E00 molecular condensate scaffold activity (GO:0140693) 47 0 .01 - < 0.01 1.00E00 1.00E00 phosphoribosylformylglycinamidine cyclo-ligase activity (GO:0004641) 1 0 .00 - < 0.01 1.00E00 1.00E00 very long-chain fatty acid omega-hydroxylase activity (GO:0140692) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA folding chaperone (GO:0140691) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AQ104 methyltransferase activity (GO:1990259) 10 0 .00 - < 0.01 1.00E00 1.00E00 CDP-glycerol diphosphatase activity (GO:0047734) 1 0 .00 - < 0.01 1.00E00 1.00E00 magnesium ion binding (GO:0000287) 231 0 .07 - < 0.01 1.00E00 1.00E00 keratin filament binding (GO:1990254) 6 0 .00 - < 0.01 1.00E00 1.00E00 1-phosphatidylinositol-3-phosphate 5-kinase activity (GO:0000285) 3 0 .00 - < 0.01 1.00E00 1.00E00 carnosine synthase activity (GO:0047730) 1 0 .00 - < 0.01 1.00E00 1.00E00 geranylgeranyl reductase activity (GO:0045550) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity (GO:0004639) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphoribosylaminoimidazole carboxylase activity (GO:0004638) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphoribosylamine-glycine ligase activity (GO:0004637) 1 0 .00 - < 0.01 1.00E00 1.00E00 stalled ribosome sensor activity (GO:0170011) 4 0 .00 - < 0.01 1.00E00 1.00E00 phosphopyruvate hydratase activity (GO:0004634) 4 0 .00 - < 0.01 1.00E00 1.00E00 FAD-dependent histone H3K9me/H3K9me2 demethylase activity (GO:0140685) 4 0 .00 - < 0.01 1.00E00 1.00E00 phosphopantothenoylcysteine decarboxylase activity (GO:0004633) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K9me2/H3K9me3 demethylase activity (GO:0140684) 5 0 .00 - < 0.01 1.00E00 1.00E00 phosphopantothenate--cysteine ligase activity (GO:0004632) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K9me/H3K9me2 demethylase activity (GO:0140683) 5 0 .00 - < 0.01 1.00E00 1.00E00 phosphomevalonate kinase activity (GO:0004631) 1 0 .00 - < 0.01 1.00E00 1.00E00 FAD-dependent H3K4me/H3K4me3 demethylase activity (GO:0140682) 2 0 .00 - < 0.01 1.00E00 1.00E00 phospholipase D activity (GO:0004630) 5 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K36me2/H3K36me3 demethylase activity (GO:0140681) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K36me/H3K36me2 demethylase activity (GO:0140680) 4 0 .00 - < 0.01 1.00E00 1.00E00 RNA strand annealing activity (GO:0033592) 5 0 .00 - < 0.01 1.00E00 1.00E00 N6-methyladenosine-containing RNA reader activity (GO:1990247) 12 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AT120 kinase activity (GO:1990244) 244 0 .07 - < 0.01 1.00E00 1.00E00 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity (GO:0045547) 2 0 .00 - < 0.01 1.00E00 1.00E00 syndecan binding (GO:0045545) 5 0 .00 - < 0.01 1.00E00 1.00E00 endoplasmic reticulum-organelle membrane tether activity (GO:0170009) 4 0 .00 - < 0.01 1.00E00 1.00E00 phospholipase C activity (GO:0004629) 29 0 .01 - < 0.01 1.00E00 1.00E00 molecular function inhibitor activity (GO:0140678) 573 0 .17 - < 0.01 1.00E00 1.00E00 molecular function activator activity (GO:0140677) 1204 0 .35 - < 0.01 1.00E00 1.00E00 phospholipase A2 activity (GO:0004623) 35 0 .01 - < 0.01 1.00E00 1.00E00 ATP-dependent histone chaperone activity (GO:0140674) 1 0 .00 - < 0.01 1.00E00 1.00E00 lysophospholipase activity (GO:0004622) 25 0 .01 - < 0.01 1.00E00 1.00E00 glycosylphosphatidylinositol phospholipase D activity (GO:0004621) 1 0 .00 - < 0.01 1.00E00 1.00E00 phospholipase activity (GO:0004620) 110 0 .03 - < 0.01 1.00E00 1.00E00 bile acid-gated sodium channel activity (GO:0160228) 1 0 .00 - < 0.01 1.00E00 1.00E00 indanol dehydrogenase activity (GO:0047718) 3 0 .00 - < 0.01 1.00E00 1.00E00 steroid hormone binding (GO:1990239) 6 0 .00 - < 0.01 1.00E00 1.00E00 3-demethoxyubiquinone 3-hydroxylase (NADH) activity (GO:0160224) 1 0 .00 - < 0.01 1.00E00 1.00E00 double-stranded DNA endonuclease activity (GO:1990238) 1 0 .00 - < 0.01 1.00E00 1.00E00 galactolipase activity (GO:0047714) 1 0 .00 - < 0.01 1.00E00 1.00E00 peroxisome targeting sequence binding (GO:0000268) 5 0 .00 - < 0.01 1.00E00 1.00E00 bis(5'-adenosyl)-triphosphatase activity (GO:0047710) 3 0 .00 - < 0.01 1.00E00 1.00E00 chemokine (C-C motif) ligand 21 binding (GO:0035758) 1 0 .00 - < 0.01 1.00E00 1.00E00 chemokine (C-C motif) ligand 19 binding (GO:0035757) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphoglycerate mutase activity (GO:0004619) 4 0 .00 - < 0.01 1.00E00 1.00E00 phosphoglycerate kinase activity (GO:0004618) 2 0 .00 - < 0.01 1.00E00 1.00E00 cardiolipin hydrolase activity (GO:0035755) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphoglycerate dehydrogenase activity (GO:0004617) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphogluconate dehydrogenase (decarboxylating) activity (GO:0004616) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphomannomutase activity (GO:0004615) 2 0 .00 - < 0.01 1.00E00 1.00E00 annealing activity (GO:0140666) 13 0 .00 - < 0.01 1.00E00 1.00E00 phosphoglucomutase activity (GO:0004614) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphoenolpyruvate carboxykinase (GTP) activity (GO:0004613) 2 0 .00 - < 0.01 1.00E00 1.00E00 ATP-dependent DNA damage sensor activity (GO:0140664) 20 0 .01 - < 0.01 1.00E00 1.00E00 ATP-dependent FeS chaperone activity (GO:0140663) 3 0 .00 - < 0.01 1.00E00 1.00E00 phosphoenolpyruvate carboxykinase activity (GO:0004611) 2 0 .00 - < 0.01 1.00E00 1.00E00 ATP-dependent protein folding chaperone (GO:0140662) 40 0 .01 - < 0.01 1.00E00 1.00E00 phosphoacetylglucosamine mutase activity (GO:0004610) 1 0 .00 - < 0.01 1.00E00 1.00E00 biotinidase activity (GO:0047708) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein lysine delactylase activity (GO:0160216) 3 0 .00 - < 0.01 1.00E00 1.00E00 deacylase activity (GO:0160215) 66 0 .02 - < 0.01 1.00E00 1.00E00 bile-salt sulfotransferase activity (GO:0047704) 2 0 .00 - < 0.01 1.00E00 1.00E00 glycine-gated cation channel activity (GO:0160212) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone methyltransferase binding (GO:1990226) 17 0 .00 - < 0.01 1.00E00 1.00E00 C-4 methylsterol oxidase activity (GO:0000254) 3 0 .00 - < 0.01 1.00E00 1.00E00 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity (GO:0000253) 5 0 .00 - < 0.01 1.00E00 1.00E00 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity (GO:0000252) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-27 receptor binding (GO:0045523) 2 0 .00 - < 0.01 1.00E00 1.00E00 lanosterol synthase activity (GO:0000250) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylserine decarboxylase activity (GO:0004609) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylethanolamine N-methyltransferase activity (GO:0004608) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylcholine-sterol O-acyltransferase activity (GO:0004607) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATP-dependent chromatin remodeler activity (GO:0140658) 20 0 .01 - < 0.01 1.00E00 1.00E00 ATP-dependent activity (GO:0140657) 584 0 .17 - < 0.01 1.00E00 1.00E00 phosphatidate cytidylyltransferase activity (GO:0004605) 3 0 .00 - < 0.01 1.00E00 1.00E00 phenylethanolamine N-methyltransferase activity (GO:0004603) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutathione peroxidase activity (GO:0004602) 23 0 .01 - < 0.01 1.00E00 1.00E00 peroxidase activity (GO:0004601) 56 0 .02 - < 0.01 1.00E00 1.00E00 folate reductase activity (GO:0033560) 1 0 .00 - < 0.01 1.00E00 1.00E00 mitochondrion-mitochondrion outer membrane tether activity (GO:0160204) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein tag activity (GO:0031386) 15 0 .00 - < 0.01 1.00E00 1.00E00 C-5 sterol desaturase activity (GO:0000248) 2 0 .00 - < 0.01 1.00E00 1.00E00 C-8 sterol isomerase activity (GO:0000247) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-23 receptor binding (GO:0045519) 2 0 .00 - < 0.01 1.00E00 1.00E00 Delta24(24-1) sterol reductase activity (GO:0000246) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-22 receptor binding (GO:0045518) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-20 receptor binding (GO:0045517) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-18 receptor binding (GO:0045515) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-27 binding (GO:0045513) 1 0 .00 - < 0.01 1.00E00 1.00E00 cardiolipin synthase (CMP-forming) (GO:0043337) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein lysine deacetylase activity (GO:0033558) 23 0 .01 - < 0.01 1.00E00 1.00E00 dinitrosyl-iron complex binding (GO:0035731) 1 0 .00 - < 0.01 1.00E00 1.00E00 S-nitrosoglutathione binding (GO:0035730) 1 0 .00 - < 0.01 1.00E00 1.00E00 catalytic activity, acting on a nucleic acid (GO:0140640) 618 0 .18 - < 0.01 1.00E00 1.00E00 MAP kinase tyrosine phosphatase activity (GO:0033550) 6 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-27 receptor activity (GO:0045509) 2 0 .00 - < 0.01 1.00E00 1.00E00 eukaryotic initiation factor 4G binding (GO:0031370) 1 0 .00 - < 0.01 1.00E00 1.00E00 dynein intermediate chain binding (GO:0045505) 36 0 .01 - < 0.01 1.00E00 1.00E00 dynein heavy chain binding (GO:0045504) 15 0 .00 - < 0.01 1.00E00 1.00E00 dynein light chain binding (GO:0045503) 9 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,4-bisphosphate binding (GO:0043325) 29 0 .01 - < 0.01 1.00E00 1.00E00 lysophosphatidic acid binding (GO:0035727) 8 0 .00 - < 0.01 1.00E00 1.00E00 MAP kinase phosphatase activity (GO:0033549) 81 0 .02 - < 0.01 1.00E00 1.00E00 translation initiation factor binding (GO:0031369) 33 0 .01 - < 0.01 1.00E00 1.00E00 N-acetylglucosaminylphosphatidylinositol deacetylase activity (GO:0000225) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity (GO:0000224) 1 0 .00 - < 0.01 1.00E00 1.00E00 macrophage migration inhibitory factor binding (GO:0035718) 2 0 .00 - < 0.01 1.00E00 1.00E00 chemokine (C-C motif) ligand 7 binding (GO:0035717) 2 0 .00 - < 0.01 1.00E00 1.00E00 chemokine (C-C motif) ligand 12 binding (GO:0035716) 1 0 .00 - < 0.01 1.00E00 1.00E00 chemokine (C-C motif) ligand 2 binding (GO:0035715) 1 0 .00 - < 0.01 1.00E00 1.00E00 delta-catenin binding (GO:0070097) 11 0 .00 - < 0.01 1.00E00 1.00E00 opioid growth factor receptor activity (GO:0140625) 2 0 .00 - < 0.01 1.00E00 1.00E00 fructose-6-phosphate binding (GO:0070095) 5 0 .00 - < 0.01 1.00E00 1.00E00 DNA secondary structure binding (GO:0000217) 39 0 .01 - < 0.01 1.00E00 1.00E00 tRNA 2'-phosphotransferase activity (GO:0000215) 2 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-intron endonuclease activity (GO:0000213) 2 0 .00 - < 0.01 1.00E00 1.00E00 NAD+ diphosphatase activity (GO:0000210) 3 0 .00 - < 0.01 1.00E00 1.00E00 very-long-chain fatty acyl-CoA dehydrogenase activity (GO:0017099) 3 0 .00 - < 0.01 1.00E00 1.00E00 chloride-activated potassium channel activity (GO:0070089) 1 0 .00 - < 0.01 1.00E00 1.00E00 sulfonylurea receptor binding (GO:0017098) 2 0 .00 - < 0.01 1.00E00 1.00E00 iodotyrosine deiodinase activity (GO:0140616) 1 0 .00 - < 0.01 1.00E00 1.00E00 chromo shadow domain binding (GO:0070087) 6 0 .00 - < 0.01 1.00E00 1.00E00 acetylserotonin O-methyltransferase activity (GO:0017096) 1 0 .00 - < 0.01 1.00E00 1.00E00 heparan sulfate 6-sulfotransferase activity (GO:0017095) 3 0 .00 - < 0.01 1.00E00 1.00E00 P-type manganese transporter activity (GO:0140613) 2 0 .00 - < 0.01 1.00E00 1.00E00 DNA damage sensor activity (GO:0140612) 24 0 .01 - < 0.01 1.00E00 1.00E00 RNA sequestering activity (GO:0140610) 2 0 .00 - < 0.01 1.00E00 1.00E00 titin Z domain binding (GO:0070080) 2 0 .00 - < 0.01 1.00E00 1.00E00 cysteine-type endopeptidase activator activity (GO:0140608) 11 0 .00 - < 0.01 1.00E00 1.00E00 glycolipid transfer activity (GO:0017089) 4 0 .00 - < 0.01 1.00E00 1.00E00 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity (GO:0017083) 6 0 .00 - < 0.01 1.00E00 1.00E00 chloride channel regulator activity (GO:0017081) 14 0 .00 - < 0.01 1.00E00 1.00E00 sodium channel regulator activity (GO:0017080) 40 0 .01 - < 0.01 1.00E00 1.00E00 oxidative phosphorylation uncoupler activity (GO:0017077) 5 0 .00 - < 0.01 1.00E00 1.00E00 purine nucleotide binding (GO:0017076) 1970 1 .57 + 1.74 4.53E-01 1.00E00 syntaxin-1 binding (GO:0017075) 18 0 .01 - < 0.01 1.00E00 1.00E00 proline-rich region binding (GO:0070064) 18 0 .01 - < 0.01 1.00E00 1.00E00 RNA polymerase binding (GO:0070063) 59 0 .02 - < 0.01 1.00E00 1.00E00 fructose binding (GO:0070061) 7 0 .00 - < 0.01 1.00E00 1.00E00 U6 snRNA binding (GO:0017070) 14 0 .00 - < 0.01 1.00E00 1.00E00 hexitol dehydrogenase activity (GO:0031320) 1 0 .00 - < 0.01 1.00E00 1.00E00 carboxylic ester hydrolase activity (GO:0052689) 106 0 .03 - < 0.01 1.00E00 1.00E00 snRNA binding (GO:0017069) 47 0 .01 - < 0.01 1.00E00 1.00E00 single-strand selective uracil DNA N-glycosylase activity (GO:0017065) 1 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid amide hydrolase activity (GO:0017064) 4 0 .00 - < 0.01 1.00E00 1.00E00 thrombospondin receptor activity (GO:0070053) 4 0 .00 - < 0.01 1.00E00 1.00E00 collagen V binding (GO:0070052) 3 0 .00 - < 0.01 1.00E00 1.00E00 S-methyl-5-thioadenosine phosphorylase activity (GO:0017061) 2 0 .00 - < 0.01 1.00E00 1.00E00 fibrinogen binding (GO:0070051) 7 0 .00 - < 0.01 1.00E00 1.00E00 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity (GO:0017060) 2 0 .00 - < 0.01 1.00E00 1.00E00 deaminase activity (GO:0019239) 33 0 .01 - < 0.01 1.00E00 1.00E00 cyclohydrolase activity (GO:0019238) 5 0 .00 - < 0.01 1.00E00 1.00E00 centromeric DNA binding (GO:0019237) 6 0 .00 - < 0.01 1.00E00 1.00E00 alkylthioltransferase activity (GO:0050497) 2 0 .00 - < 0.01 1.00E00 1.00E00 6-phosphogluconolactonase activity (GO:0017057) 2 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of nuclear pore (GO:0017056) 25 0 .01 - < 0.01 1.00E00 1.00E00 rRNA (uridine-N3-)-methyltransferase activity (GO:0070042) 1 0 .00 - < 0.01 1.00E00 1.00E00 rRNA (uridine-C5-)-methyltransferase activity (GO:0070041) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-erythro-sphingosine kinase activity (GO:0017050) 3 0 .00 - < 0.01 1.00E00 1.00E00 retinoic acid binding (GO:0001972) 20 0 .01 - < 0.01 1.00E00 1.00E00 GTPase activator activity (GO:0005096) 272 0 .08 - < 0.01 1.00E00 1.00E00 GTPase inhibitor activity (GO:0005095) 12 0 .00 - < 0.01 1.00E00 1.00E00 Rho GDP-dissociation inhibitor activity (GO:0005094) 3 0 .00 - < 0.01 1.00E00 1.00E00 Rab GDP-dissociation inhibitor activity (GO:0005093) 2 0 .00 - < 0.01 1.00E00 1.00E00 GDP-dissociation inhibitor activity (GO:0005092) 17 0 .00 - < 0.01 1.00E00 1.00E00 guanyl-nucleotide exchange factor adaptor activity (GO:0005091) 1 0 .00 - < 0.01 1.00E00 1.00E00 intramolecular hydroxytransferase activity (GO:0050486) 2 0 .00 - < 0.01 1.00E00 1.00E00 GMP 5'-nucleotidase activity (GO:0050484) 2 0 .00 - < 0.01 1.00E00 1.00E00 IMP 5'-nucleotidase activity (GO:0050483) 4 0 .00 - < 0.01 1.00E00 1.00E00 amide transmembrane transporter activity (GO:0042887) 38 0 .01 - < 0.01 1.00E00 1.00E00 rRNA (guanosine-2'-O-)-methyltransferase activity (GO:0070039) 2 0 .00 - < 0.01 1.00E00 1.00E00 activin binding (GO:0048185) 11 0 .00 - < 0.01 1.00E00 1.00E00 imidazolonepropionase activity (GO:0050480) 1 0 .00 - < 0.01 1.00E00 1.00E00 rRNA (pseudouridine) methyltransferase activity (GO:0070037) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptide hormone binding (GO:0017046) 54 0 .02 - < 0.01 1.00E00 1.00E00 corticotropin-releasing hormone activity (GO:0017045) 1 0 .00 - < 0.01 1.00E00 1.00E00 telomerase RNA binding (GO:0070034) 22 0 .01 - < 0.01 1.00E00 1.00E00 glycosylceramidase activity (GO:0017042) 5 0 .00 - < 0.01 1.00E00 1.00E00 D-glucuronate transmembrane transporter activity (GO:0042880) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acylsphingosine amidohydrolase activity (GO:0017040) 7 0 .00 - < 0.01 1.00E00 1.00E00 fibronectin binding (GO:0001968) 30 0 .01 - < 0.01 1.00E00 1.00E00 G-protein alpha-subunit binding (GO:0001965) 30 0 .01 - < 0.01 1.00E00 1.00E00 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity (GO:0052659) 6 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,4,5-trisphosphate 5-phosphatase activity (GO:0052658) 7 0 .00 - < 0.01 1.00E00 1.00E00 guanine phosphoribosyltransferase activity (GO:0052657) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-isoleucine-2-oxoglutarate transaminase activity (GO:0052656) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-valine-2-oxoglutarate transaminase activity (GO:0052655) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-leucine-2-oxoglutarate transaminase activity (GO:0052654) 2 0 .00 - < 0.01 1.00E00 1.00E00 guanyl-nucleotide exchange factor activity (GO:0005085) 233 0 .07 - < 0.01 1.00E00 1.00E00 glyceryl-ether monooxygenase activity (GO:0050479) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein kinase C binding (GO:0005080) 52 0 .02 - < 0.01 1.00E00 1.00E00 intermediate filament binding (GO:0019215) 11 0 .00 - < 0.01 1.00E00 1.00E00 deacetylase activity (GO:0019213) 38 0 .01 - < 0.01 1.00E00 1.00E00 arachidonate 15-lipoxygenase activity (GO:0050473) 3 0 .00 - < 0.01 1.00E00 1.00E00 phosphatase inhibitor activity (GO:0019212) 59 0 .02 - < 0.01 1.00E00 1.00E00 phosphatase activator activity (GO:0019211) 28 0 .01 - < 0.01 1.00E00 1.00E00 kinase inhibitor activity (GO:0019210) 93 0 .03 - < 0.01 1.00E00 1.00E00 nitric oxide binding (GO:0070026) 4 0 .00 - < 0.01 1.00E00 1.00E00 carbon monoxide binding (GO:0070025) 2 0 .00 - < 0.01 1.00E00 1.00E00 decanoate-CoA ligase activity (GO:0102391) 4 0 .00 - < 0.01 1.00E00 1.00E00 mycophenolic acid acyl-glucuronide esterase activity (GO:0102390) 1 0 .00 - < 0.01 1.00E00 1.00E00 nucleoside phosphate binding (GO:1901265) 2153 1 .63 + 1.59 4.85E-01 1.00E00 MAP-kinase scaffold activity (GO:0005078) 12 0 .00 - < 0.01 1.00E00 1.00E00 kinase activator activity (GO:0019209) 153 0 .04 - < 0.01 1.00E00 1.00E00 lysophosphatidic acid phosphatase activity (GO:0052642) 5 0 .00 - < 0.01 1.00E00 1.00E00 phosphatase regulator activity (GO:0019208) 121 0 .04 - < 0.01 1.00E00 1.00E00 kinase regulator activity (GO:0019207) 295 0 .09 - < 0.01 1.00E00 1.00E00 nucleoside kinase activity (GO:0019206) 11 0 .00 - < 0.01 1.00E00 1.00E00 nucleobase-containing compound kinase activity (GO:0019205) 45 0 .01 - < 0.01 1.00E00 1.00E00 polyprenol reductase activity (GO:0102389) 1 0 .00 - < 0.01 1.00E00 1.00E00 carbohydrate phosphatase activity (GO:0019203) 13 0 .00 - < 0.01 1.00E00 1.00E00 amino acid kinase activity (GO:0019202) 2 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylneuraminate synthase activity (GO:0050462) 1 0 .00 - < 0.01 1.00E00 1.00E00 carbohydrate kinase activity (GO:0019200) 21 0 .01 - < 0.01 1.00E00 1.00E00 armadillo repeat domain binding (GO:0070016) 8 0 .00 - < 0.01 1.00E00 1.00E00 TBP-class protein binding (GO:0017025) 25 0 .01 - < 0.01 1.00E00 1.00E00 myosin I binding (GO:0017024) 1 0 .00 - < 0.01 1.00E00 1.00E00 myosin binding (GO:0017022) 76 0 .02 - < 0.01 1.00E00 1.00E00 oligopeptidase activity (GO:0070012) 2 0 .00 - < 0.01 1.00E00 1.00E00 myosin phosphatase regulator activity (GO:0017020) 6 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068) 17 0 .00 - < 0.01 1.00E00 1.00E00 lipoprotein lipase activator activity (GO:0060230) 4 0 .00 - < 0.01 1.00E00 1.00E00 ethanolamine-phosphate phospho-lyase activity (GO:0050459) 1 0 .00 - < 0.01 1.00E00 1.00E00 UDP-N-acetylgalactosamine diphosphorylase activity (GO:0052630) 1 0 .00 - < 0.01 1.00E00 1.00E00 tau protein binding (GO:0048156) 44 0 .01 - < 0.01 1.00E00 1.00E00 serine-type aminopeptidase activity (GO:0070009) 1 0 .00 - < 0.01 1.00E00 1.00E00 myosin phosphatase activity (GO:0017018) 83 0 .02 - < 0.01 1.00E00 1.00E00 serine-type exopeptidase activity (GO:0070008) 12 0 .00 - < 0.01 1.00E00 1.00E00 fluoride transmembrane transporter activity (GO:1903425) 1 0 .00 - < 0.01 1.00E00 1.00E00 MAP kinase tyrosine/serine/threonine phosphatase activity (GO:0017017) 13 0 .00 - < 0.01 1.00E00 1.00E00 metalloaminopeptidase activity (GO:0070006) 26 0 .01 - < 0.01 1.00E00 1.00E00 cysteine-type aminopeptidase activity (GO:0070005) 2 0 .00 - < 0.01 1.00E00 1.00E00 cysteine-type exopeptidase activity (GO:0070004) 9 0 .00 - < 0.01 1.00E00 1.00E00 threonine-type peptidase activity (GO:0070003) 19 0 .01 - < 0.01 1.00E00 1.00E00 glutamic-type peptidase activity (GO:0070002) 1 0 .00 - < 0.01 1.00E00 1.00E00 aspartic-type peptidase activity (GO:0070001) 39 0 .01 - < 0.01 1.00E00 1.00E00 lipase activator activity (GO:0060229) 24 0 .01 - < 0.01 1.00E00 1.00E00 phosphatidylcholine-sterol O-acyltransferase activator activity (GO:0060228) 6 0 .00 - < 0.01 1.00E00 1.00E00 calcium-dependent ATPase activity (GO:0030899) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity (GO:0052629) 12 0 .00 - < 0.01 1.00E00 1.00E00 laminin receptor activity (GO:0005055) 5 0 .00 - < 0.01 1.00E00 1.00E00 peroxisome matrix targeting signal-2 binding (GO:0005053) 1 0 .00 - < 0.01 1.00E00 1.00E00 peroxisome matrix targeting signal-1 binding (GO:0005052) 2 0 .00 - < 0.01 1.00E00 1.00E00 3'-tyrosyl-DNA phosphodiesterase activity (GO:0017005) 1 0 .00 - < 0.01 1.00E00 1.00E00 activin receptor activity (GO:0017002) 12 0 .00 - < 0.01 1.00E00 1.00E00 (R)-carnitine transmembrane transporter activity (GO:1901235) 3 0 .00 - < 0.01 1.00E00 1.00E00 nuclear export signal receptor activity (GO:0005049) 12 0 .00 - < 0.01 1.00E00 1.00E00 signal sequence binding (GO:0005048) 48 0 .01 - < 0.01 1.00E00 1.00E00 13-lipoxin reductase activity (GO:0036185) 1 0 .00 - < 0.01 1.00E00 1.00E00 signal recognition particle binding (GO:0005047) 8 0 .00 - < 0.01 1.00E00 1.00E00 KDEL sequence binding (GO:0005046) 3 0 .00 - < 0.01 1.00E00 1.00E00 exogenous lipid antigen binding (GO:0030884) 5 0 .00 - < 0.01 1.00E00 1.00E00 endogenous lipid antigen binding (GO:0030883) 5 0 .00 - < 0.01 1.00E00 1.00E00 scavenger receptor activity (GO:0005044) 27 0 .01 - < 0.01 1.00E00 1.00E00 lipid antigen binding (GO:0030882) 5 0 .00 - < 0.01 1.00E00 1.00E00 netrin receptor activity involved in chemorepulsion (GO:0005043) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-2-microglobulin binding (GO:0030881) 8 0 .00 - < 0.01 1.00E00 1.00E00 netrin receptor activity (GO:0005042) 5 0 .00 - < 0.01 1.00E00 1.00E00 low-density lipoprotein particle receptor activity (GO:0005041) 15 0 .00 - < 0.01 1.00E00 1.00E00 microfibril binding (GO:0050436) 6 0 .00 - < 0.01 1.00E00 1.00E00 protein serine pyrophosphorylase activity (GO:0141090) 1 0 .00 - < 0.01 1.00E00 1.00E00 transforming growth factor beta binding (GO:0050431) 24 0 .01 - < 0.01 1.00E00 1.00E00 BRE binding (GO:0042835) 2 0 .00 - < 0.01 1.00E00 1.00E00 11-cis-retinol dehydrogenase activity (GO:0102354) 3 0 .00 - < 0.01 1.00E00 1.00E00 peptidoglycan binding (GO:0042834) 19 0 .01 - < 0.01 1.00E00 1.00E00 K6-linked polyubiquitin modification-dependent protein binding (GO:0071796) 2 0 .00 - < 0.01 1.00E00 1.00E00 K11-linked polyubiquitin modification-dependent protein binding (GO:0071795) 1 0 .00 - < 0.01 1.00E00 1.00E00 chemokine (C-C motif) ligand 5 binding (GO:0071791) 2 0 .00 - < 0.01 1.00E00 1.00E00 farnesylated protein binding (GO:0001918) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucose sensor activity (GO:0141089) 2 0 .00 - < 0.01 1.00E00 1.00E00 death receptor activity (GO:0005035) 13 0 .00 - < 0.01 1.00E00 1.00E00 osmosensor activity (GO:0005034) 6 0 .00 - < 0.01 1.00E00 1.00E00 calcium-dependent phospholipase C activity (GO:0050429) 2 0 .00 - < 0.01 1.00E00 1.00E00 tumor necrosis factor receptor activity (GO:0005031) 10 0 .00 - < 0.01 1.00E00 1.00E00 neurotrophin receptor activity (GO:0005030) 51 0 .01 - < 0.01 1.00E00 1.00E00 histone deacetylase binding (GO:0042826) 124 0 .04 - < 0.01 1.00E00 1.00E00 nitrite reductase (NO-forming) activity (GO:0050421) 4 0 .00 - < 0.01 1.00E00 1.00E00 transforming growth factor beta receptor activity, type II (GO:0005026) 12 0 .00 - < 0.01 1.00E00 1.00E00 transforming growth factor beta receptor activity, type I (GO:0005025) 12 0 .00 - < 0.01 1.00E00 1.00E00 transforming growth factor beta receptor activity (GO:0005024) 16 0 .00 - < 0.01 1.00E00 1.00E00 vascular endothelial growth factor receptor activity (GO:0005021) 51 0 .01 - < 0.01 1.00E00 1.00E00 stem cell factor receptor activity (GO:0005020) 49 0 .01 - < 0.01 1.00E00 1.00E00 Wnt receptor activity (GO:0042813) 15 0 .00 - < 0.01 1.00E00 1.00E00 platelet-derived growth factor beta-receptor activity (GO:0005019) 50 0 .01 - < 0.01 1.00E00 1.00E00 platelet-derived growth factor alpha-receptor activity (GO:0005018) 49 0 .01 - < 0.01 1.00E00 1.00E00 receptor ligand inhibitor activity (GO:0141069) 7 0 .00 - < 0.01 1.00E00 1.00E00 platelet-derived growth factor receptor activity (GO:0005017) 50 0 .01 - < 0.01 1.00E00 1.00E00 macrophage colony-stimulating factor receptor activity (GO:0005011) 49 0 .01 - < 0.01 1.00E00 1.00E00 insulin-like growth factor receptor activity (GO:0005010) 51 0 .01 - < 0.01 1.00E00 1.00E00 nuclear vitamin D receptor binding (GO:0042809) 15 0 .00 - < 0.01 1.00E00 1.00E00 fucose binding (GO:0042806) 8 0 .00 - < 0.01 1.00E00 1.00E00 actinin binding (GO:0042805) 37 0 .01 - < 0.01 1.00E00 1.00E00 protein homodimerization activity (GO:0042803) 729 1 .21 + 4.71 1.95E-01 1.00E00 identical protein binding (GO:0042802) 2215 2 .65 + 3.10 1.30E-01 1.00E00 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity (GO:0048101) 11 0 .00 - < 0.01 1.00E00 1.00E00 1,8-cineole 2-exo-monooxygenase activity (GO:0102320) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K4 methyltransferase activity (GO:0042800) 19 0 .01 - < 0.01 1.00E00 1.00E00 acetylpyruvate hydrolase activity (GO:0018773) 1 0 .00 - < 0.01 1.00E00 1.00E00 amino acid binding (GO:0016597) 51 0 .01 - < 0.01 1.00E00 1.00E00 glutamate binding (GO:0016595) 9 0 .00 - < 0.01 1.00E00 1.00E00 protein-N-terminal-alanine acetyltransferase activity (GO:0008999) 2 0 .00 - < 0.01 1.00E00 1.00E00 glycine binding (GO:0016594) 11 0 .00 - < 0.01 1.00E00 1.00E00 ribonuclease E activity (GO:0008995) 1 0 .00 - < 0.01 1.00E00 1.00E00 insulin receptor activity (GO:0005009) 49 0 .01 - < 0.01 1.00E00 1.00E00 hepatocyte growth factor receptor activity (GO:0005008) 49 0 .01 - < 0.01 1.00E00 1.00E00 fibroblast growth factor receptor activity (GO:0005007) 50 0 .01 - < 0.01 1.00E00 1.00E00 histone H4 demethylase activity (GO:0141058) 5 0 .00 - < 0.01 1.00E00 1.00E00 epidermal growth factor receptor activity (GO:0005006) 50 0 .01 - < 0.01 1.00E00 1.00E00 kringle domain binding (GO:0036143) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3 arginine deiminase activity (GO:0141057) 4 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane-ephrin receptor activity (GO:0005005) 53 0 .02 - < 0.01 1.00E00 1.00E00 regulatory RNA binding (GO:0061980) 49 0 .01 - < 0.01 1.00E00 1.00E00 histone H4 ubiquitin ligase activity (GO:0141056) 1 0 .00 - < 0.01 1.00E00 1.00E00 GPI-linked ephrin receptor activity (GO:0005004) 49 0 .01 - < 0.01 1.00E00 1.00E00 histone H3 ubiquitin ligase activity (GO:0141055) 1 0 .00 - < 0.01 1.00E00 1.00E00 ephrin receptor activity (GO:0005003) 53 0 .02 - < 0.01 1.00E00 1.00E00 [protein]-asparagine 3-dioxygenase activity (GO:0036140) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H2B ubiquitin ligase activity (GO:0141054) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H2A ubiquitin ligase activity (GO:0141053) 8 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane receptor protein tyrosine phosphatase activity (GO:0005001) 17 0 .00 - < 0.01 1.00E00 1.00E00 histone H3 demethylase activity (GO:0141052) 28 0 .01 - < 0.01 1.00E00 1.00E00 vasopressin receptor activity (GO:0005000) 7 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K deacetylase activity (GO:0141051) 15 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K deacetylase activity (GO:0141050) 15 0 .00 - < 0.01 1.00E00 1.00E00 rRNA (adenine-N6-)-methyltransferase activity (GO:0008988) 3 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-histidine dioxygenase activity (GO:0036139) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein-glutamate O-methyltransferase activity (GO:0008983) 1 0 .00 - < 0.01 1.00E00 1.00E00 12-hydroxyheptadecatrienoic acid synthase activity (GO:0036134) 3 0 .00 - < 0.01 1.00E00 1.00E00 molecular tag activity (GO:0141047) 15 0 .00 - < 0.01 1.00E00 1.00E00 Atg8-family conjugating enzyme activity (GO:0141046) 1 0 .00 - < 0.01 1.00E00 1.00E00 prostaglandin D2 11-ketoreductase activity (GO:0036131) 1 0 .00 - < 0.01 1.00E00 1.00E00 prostaglandin H2 endoperoxidase reductase activity (GO:0036130) 2 0 .00 - < 0.01 1.00E00 1.00E00 very-long-chain 3-oxoacyl-CoA reductase activity (GO:0141040) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphopentomutase activity (GO:0008973) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol 3-kinase inhibitor activity (GO:0141039) 6 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol 3-kinase activator activity (GO:0141038) 6 0 .00 - < 0.01 1.00E00 1.00E00 phospholipase A1 activity (GO:0008970) 22 0 .01 - < 0.01 1.00E00 1.00E00 BMP binding (GO:0036122) 20 0 .01 - < 0.01 1.00E00 1.00E00 double-stranded DNA helicase activity (GO:0036121) 48 0 .01 - < 0.01 1.00E00 1.00E00 phosphoglycolate phosphatase activity (GO:0008967) 2 0 .00 - < 0.01 1.00E00 1.00E00 mRNA (adenine-N1-)-methyltransferase activity (GO:0061953) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylglycerophosphatase activity (GO:0008962) 1 0 .00 - < 0.01 1.00E00 1.00E00 S-formylglutathione hydrolase activity (GO:0018738) 1 0 .00 - < 0.01 1.00E00 1.00E00 lipopeptide binding (GO:0071723) 10 0 .00 - < 0.01 1.00E00 1.00E00 beta-adrenergic receptor kinase activity (GO:0047696) 4 0 .00 - < 0.01 1.00E00 1.00E00 ATP diphosphatase activity (GO:0047693) 3 0 .00 - < 0.01 1.00E00 1.00E00 phenylacetaldehyde dehydrogenase (NAD+) activity (GO:0008957) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidoglycan glycosyltransferase activity (GO:0008955) 1 0 .00 - < 0.01 1.00E00 1.00E00 peroxisome membrane class-1 targeting sequence binding (GO:0036105) 1 0 .00 - < 0.01 1.00E00 1.00E00 G/T mismatch-specific thymine-DNA glycosylase activity (GO:0141016) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidylamidoglycolate lyase activity (GO:0004598) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-N-terminal amino-acid acetyltransferase activity (GO:0004596) 9 0 .00 - < 0.01 1.00E00 1.00E00 pantetheine-phosphate adenylyltransferase activity (GO:0004595) 1 0 .00 - < 0.01 1.00E00 1.00E00 pantothenate kinase activity (GO:0004594) 3 0 .00 - < 0.01 1.00E00 1.00E00 propionate CoA-transferase activity (GO:0018729) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxoglutarate dehydrogenase (succinyl-transferring) activity (GO:0004591) 3 0 .00 - < 0.01 1.00E00 1.00E00 orotidine-5'-phosphate decarboxylase activity (GO:0004590) 1 0 .00 - < 0.01 1.00E00 1.00E00 polyprenal reductase activity (GO:0160198) 1 0 .00 - < 0.01 1.00E00 1.00E00 icosanoid transmembrane transporter activity (GO:0071714) 13 0 .00 - < 0.01 1.00E00 1.00E00 dolichal reductase [NAD(P)+] activity (GO:0160197) 1 0 .00 - < 0.01 1.00E00 1.00E00 polyprenol dehydrogenase activity (GO:0160196) 1 0 .00 - < 0.01 1.00E00 1.00E00 amine sulfotransferase activity (GO:0047685) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-lactate dehydrogenase inhibitor activity (GO:0160193) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxaloacetate decarboxylase activity (GO:0008948) 4 0 .00 - < 0.01 1.00E00 1.00E00 oligonucleotidase activity (GO:0008946) 1 0 .00 - < 0.01 1.00E00 1.00E00 nitrate reductase activity (GO:0008940) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AX kinase activity (GO:0141003) 245 0 .07 - < 0.01 1.00E00 1.00E00 orotate phosphoribosyltransferase activity (GO:0004588) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K91 ubiquitin ligase activity (GO:0141000) 1 0 .00 - < 0.01 1.00E00 1.00E00 ornithine aminotransferase activity (GO:0004587) 1 0 .00 - < 0.01 1.00E00 1.00E00 ornithine decarboxylase activity (GO:0004586) 2 0 .00 - < 0.01 1.00E00 1.00E00 ornithine carbamoyltransferase activity (GO:0004585) 1 0 .00 - < 0.01 1.00E00 1.00E00 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity (GO:0004583) 2 0 .00 - < 0.01 1.00E00 1.00E00 dolichyl-phosphate beta-D-mannosyltransferase activity (GO:0004582) 1 0 .00 - < 0.01 1.00E00 1.00E00 dolichyl-phosphate beta-glucosyltransferase activity (GO:0004581) 1 0 .00 - < 0.01 1.00E00 1.00E00 paracellular tight junction channel activity (GO:0160187) 6 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate 8(R)-lipoxygenase activity (GO:0047677) 1 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate-CoA ligase activity (GO:0047676) 11 0 .00 - < 0.01 1.00E00 1.00E00 phospholipase C activator activity (GO:0160185) 3 0 .00 - < 0.01 1.00E00 1.00E00 cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538) 48 0 .01 - < 0.01 1.00E00 1.00E00 metalloendopeptidase activity involved in amyloid precursor protein catabolic process (GO:1902945) 4 0 .00 - < 0.01 1.00E00 1.00E00 autophagosome-membrane adaptor activity (GO:0160183) 4 0 .00 - < 0.01 1.00E00 1.00E00 chemorepellent activity (GO:0045499) 28 0 .01 - < 0.01 1.00E00 1.00E00 gamma-glutamylaminecyclotransferase activity (GO:0061929) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutathione specific gamma-glutamylcyclotransferase activity (GO:0061928) 2 0 .00 - < 0.01 1.00E00 1.00E00 ferredoxin-[NAD(P)H] reductase activity (GO:0008937) 1 0 .00 - < 0.01 1.00E00 1.00E00 superoxide dismutase copper chaperone activity (GO:0016532) 3 0 .00 - < 0.01 1.00E00 1.00E00 copper chaperone activity (GO:0016531) 7 0 .00 - < 0.01 1.00E00 1.00E00 metallochaperone activity (GO:0016530) 14 0 .00 - < 0.01 1.00E00 1.00E00 protein-N-terminal-glutamate acetyltransferase activity (GO:1990190) 2 0 .00 - < 0.01 1.00E00 1.00E00 inositol monophosphate 1-phosphatase activity (GO:0008934) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein propionyltransferase activity (GO:0061920) 2 0 .00 - < 0.01 1.00E00 1.00E00 dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579) 5 0 .00 - < 0.01 1.00E00 1.00E00 chitobiosyldiphosphodolichol beta-mannosyltransferase activity (GO:0004578) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity (GO:0004577) 1 0 .00 - < 0.01 1.00E00 1.00E00 oligosaccharyl transferase activity (GO:0004576) 5 0 .00 - < 0.01 1.00E00 1.00E00 sucrose alpha-glucosidase activity (GO:0004575) 1 0 .00 - < 0.01 1.00E00 1.00E00 oligo-1,6-glucosidase activity (GO:0004574) 2 0 .00 - < 0.01 1.00E00 1.00E00 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity (GO:0004573) 1 0 .00 - < 0.01 1.00E00 1.00E00 thiol S-methyltransferase activity (GO:0018708) 2 0 .00 - < 0.01 1.00E00 1.00E00 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity (GO:0004572) 2 0 .00 - < 0.01 1.00E00 1.00E00 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (GO:0004571) 7 0 .00 - < 0.01 1.00E00 1.00E00 dipeptide uniporter activity (GO:0160178) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol bisphosphate binding (GO:1902936) 111 0 .03 - < 0.01 1.00E00 1.00E00 protein N-terminal-serine acetyltransferase activity (GO:1990189) 3 0 .00 - < 0.01 1.00E00 1.00E00 methylglyoxal synthase activity (GO:0008929) 1 0 .00 - < 0.01 1.00E00 1.00E00 latrotoxin receptor activity (GO:0016524) 2 0 .00 - < 0.01 1.00E00 1.00E00 amino-acid racemase activity (GO:0047661) 2 0 .00 - < 0.01 1.00E00 1.00E00 pituitary adenylate cyclase activating polypeptide activity (GO:0016521) 1 0 .00 - < 0.01 1.00E00 1.00E00 omega-6 fatty acid desaturase activity (GO:0045485) 1 0 .00 - < 0.01 1.00E00 1.00E00 growth hormone-releasing hormone receptor activity (GO:0016520) 3 0 .00 - < 0.01 1.00E00 1.00E00 oligopeptide binding (GO:1900750) 11 0 .00 - < 0.01 1.00E00 1.00E00 glycoprotein endo-alpha-1,2-mannosidase activity (GO:0004569) 1 0 .00 - < 0.01 1.00E00 1.00E00 chitinase activity (GO:0004568) 4 0 .00 - < 0.01 1.00E00 1.00E00 beta-mannosidase activity (GO:0004567) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-glucuronidase activity (GO:0004566) 3 0 .00 - < 0.01 1.00E00 1.00E00 beta-galactosidase activity (GO:0004565) 5 0 .00 - < 0.01 1.00E00 1.00E00 beta-fructofuranosidase activity (GO:0004564) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-N-acetylhexosaminidase activity (GO:0004563) 5 0 .00 - < 0.01 1.00E00 1.00E00 alpha-N-acetylglucosaminidase activity (GO:0004561) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-L-fucosidase activity (GO:0004560) 2 0 .00 - < 0.01 1.00E00 1.00E00 alpha-amino-acid esterase activity (GO:0047658) 1 0 .00 - < 0.01 1.00E00 1.00E00 2-oxoadipate dehydrogenase activity (GO:0160166) 1 0 .00 - < 0.01 1.00E00 1.00E00 gastric inhibitory peptide receptor activity (GO:0016519) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-12 receptor activity (GO:0016517) 1 0 .00 - < 0.01 1.00E00 1.00E00 S-nitrosoglutathione reductase (NADPH) activity (GO:0160163) 2 0 .00 - < 0.01 1.00E00 1.00E00 EH domain binding (GO:1990175) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphodiesterase decapping endonuclease activity (GO:1990174) 2 0 .00 - < 0.01 1.00E00 1.00E00 glutathione binding (GO:0043295) 10 0 .00 - < 0.01 1.00E00 1.00E00 alpha-mannosidase activity (GO:0004559) 14 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,4-glucosidase activity (GO:0004558) 5 0 .00 - < 0.01 1.00E00 1.00E00 alpha-galactosidase activity (GO:0004557) 2 0 .00 - < 0.01 1.00E00 1.00E00 alpha-amylase activity (GO:0004556) 5 0 .00 - < 0.01 1.00E00 1.00E00 alpha,alpha-trehalase activity (GO:0004555) 1 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553) 91 0 .03 - < 0.01 1.00E00 1.00E00 dinucleotide phosphatase activity (GO:0004551) 6 0 .00 - < 0.01 1.00E00 1.00E00 nucleoside diphosphate kinase activity (GO:0004550) 18 0 .01 - < 0.01 1.00E00 1.00E00 alkylglycerol kinase activity (GO:0047649) 3 0 .00 - < 0.01 1.00E00 1.00E00 long-chain-3-hydroxyacyl-CoA dehydrogenase activity (GO:0016509) 2 0 .00 - < 0.01 1.00E00 1.00E00 tRNA pseudouridine(38/39) synthase activity (GO:0160154) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidase activator activity involved in apoptotic process (GO:0016505) 16 0 .00 - < 0.01 1.00E00 1.00E00 single-strand break-containing DNA binding (GO:1990165) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidase activator activity (GO:0016504) 57 0 .02 - < 0.01 1.00E00 1.00E00 tRNA pseudouridine(13) synthase activity (GO:0160150) 1 0 .00 - < 0.01 1.00E00 1.00E00 pheromone receptor activity (GO:0016503) 6 0 .00 - < 0.01 1.00E00 1.00E00 nucleotide receptor activity (GO:0016502) 20 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K4 deacetylase activity, hydrolytic mechanism (GO:1990162) 10 0 .00 - < 0.01 1.00E00 1.00E00 prostacyclin receptor activity (GO:0016501) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-hormone receptor activity (GO:0016500) 67 0 .02 - < 0.01 1.00E00 1.00E00 hydroxypyruvate isomerase activity (GO:0008903) 1 0 .00 - < 0.01 1.00E00 1.00E00 P-type potassium:proton transporter activity (GO:0008900) 3 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-specific ribonuclease activity (GO:0004549) 16 0 .00 - < 0.01 1.00E00 1.00E00 protein carrier chaperone (GO:0140597) 40 0 .01 - < 0.01 1.00E00 1.00E00 histone H3R8 methyltransferase activity (GO:0140592) 8 0 .00 - < 0.01 1.00E00 1.00E00 RNA nuclease activity (GO:0004540) 126 0 .04 - < 0.01 1.00E00 1.00E00 tRNA pseudouridine(55) synthase activity (GO:0160148) 3 0 .00 - < 0.01 1.00E00 1.00E00 albendazole monooxygenase activity (GO:0047638) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA pseudouridine(38-40) synthase activity (GO:0160147) 1 0 .00 - < 0.01 1.00E00 1.00E00 alanine-oxo-acid transaminase activity (GO:0047635) 2 0 .00 - < 0.01 1.00E00 1.00E00 ADP-ribose diphosphatase activity (GO:0047631) 5 0 .00 - < 0.01 1.00E00 1.00E00 rDNA binding (GO:0000182) 10 0 .00 - < 0.01 1.00E00 1.00E00 phospholipase binding (GO:0043274) 23 0 .01 - < 0.01 1.00E00 1.00E00 CTPase activity (GO:0043273) 6 0 .00 - < 0.01 1.00E00 1.00E00 DNA nuclease activity (GO:0004536) 65 0 .02 - < 0.01 1.00E00 1.00E00 oligopeptide transmembrane transporter activity (GO:0035673) 13 0 .00 - < 0.01 1.00E00 1.00E00 chromatin loop anchoring activity (GO:0140587) 5 0 .00 - < 0.01 1.00E00 1.00E00 poly(A)-specific ribonuclease activity (GO:0004535) 13 0 .00 - < 0.01 1.00E00 1.00E00 5'-3' RNA exonuclease activity (GO:0004534) 4 0 .00 - < 0.01 1.00E00 1.00E00 enone reductase activity (GO:0035671) 5 0 .00 - < 0.01 1.00E00 1.00E00 promoter-enhancer loop anchoring activity (GO:0140585) 4 0 .00 - < 0.01 1.00E00 1.00E00 RNA exonuclease activity (GO:0004532) 41 0 .01 - < 0.01 1.00E00 1.00E00 deoxyribonuclease II activity (GO:0004531) 2 0 .00 - < 0.01 1.00E00 1.00E00 deoxyribonuclease I activity (GO:0004530) 5 0 .00 - < 0.01 1.00E00 1.00E00 P-type monovalent copper transporter activity (GO:0140581) 2 0 .00 - < 0.01 1.00E00 1.00E00 mitochondrion autophagosome adaptor activity (GO:0140580) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenylylsulfatase activity (GO:0047627) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-RNA sequence-specific adaptor activity (GO:0160134) 2 0 .00 - < 0.01 1.00E00 1.00E00 rRNA (adenine-N6,N6-)-dimethyltransferase activity (GO:0000179) 4 0 .00 - < 0.01 1.00E00 1.00E00 bicarbonate channel activity (GO:0160133) 3 0 .00 - < 0.01 1.00E00 1.00E00 talin binding (GO:1990147) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenosine-phosphate deaminase activity (GO:0047623) 3 0 .00 - < 0.01 1.00E00 1.00E00 acylpyruvate hydrolase activity (GO:0047621) 1 0 .00 - < 0.01 1.00E00 1.00E00 3'-5'-RNA exonuclease activity (GO:0000175) 36 0 .01 - < 0.01 1.00E00 1.00E00 acylglycerol kinase activity (GO:0047620) 1 0 .00 - < 0.01 1.00E00 1.00E00 ribonuclease MRP activity (GO:0000171) 1 0 .00 - < 0.01 1.00E00 1.00E00 sphingosine hydroxylase activity (GO:0000170) 1 0 .00 - < 0.01 1.00E00 1.00E00 ADP phosphatase activity (GO:0043262) 6 0 .00 - < 0.01 1.00E00 1.00E00 DNA exonuclease activity (GO:0004529) 27 0 .01 - < 0.01 1.00E00 1.00E00 phosphodiesterase I activity (GO:0004528) 5 0 .00 - < 0.01 1.00E00 1.00E00 exonuclease activity (GO:0004527) 86 0 .03 - < 0.01 1.00E00 1.00E00 ribonuclease P activity (GO:0004526) 11 0 .00 - < 0.01 1.00E00 1.00E00 Toll-like receptor 2 binding (GO:0035663) 4 0 .00 - < 0.01 1.00E00 1.00E00 ribonuclease III activity (GO:0004525) 2 0 .00 - < 0.01 1.00E00 1.00E00 Toll-like receptor 4 binding (GO:0035662) 4 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane monodehydroascorbate reductase activity (GO:0140575) 4 0 .00 - < 0.01 1.00E00 1.00E00 RNA-DNA hybrid ribonuclease activity (GO:0004523) 16 0 .00 - < 0.01 1.00E00 1.00E00 ribonuclease A activity (GO:0004522) 4 0 .00 - < 0.01 1.00E00 1.00E00 RNA endonuclease activity (GO:0004521) 77 0 .02 - < 0.01 1.00E00 1.00E00 protein-DNA covalent cross-linking activity (GO:0160129) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA endonuclease activity (GO:0004520) 43 0 .01 - < 0.01 1.00E00 1.00E00 transmembrane ascorbate ferrireductase activity (GO:0140571) 4 0 .00 - < 0.01 1.00E00 1.00E00 pH-gated monoatomic ion channel activity (GO:0160128) 8 0 .00 - < 0.01 1.00E00 1.00E00 fatty acyl-CoA hydrolase activity (GO:0047617) 25 0 .01 - < 0.01 1.00E00 1.00E00 pH-gated sodium channel activity (GO:0160125) 2 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of nuclear lamina (GO:0160123) 2 0 .00 - < 0.01 1.00E00 1.00E00 aconitate decarboxylase activity (GO:0047613) 1 0 .00 - < 0.01 1.00E00 1.00E00 linoleate 9S-lipoxygenase activity (GO:1990136) 2 0 .00 - < 0.01 1.00E00 1.00E00 bis(monoacylglycero)phosphate synthase activity (GO:0160121) 1 0 .00 - < 0.01 1.00E00 1.00E00 nucleotide binding (GO:0000166) 2134 1 .62 + 1.61 4.82E-01 1.00E00 acetylspermidine deacetylase activity (GO:0047611) 1 0 .00 - < 0.01 1.00E00 1.00E00 endonuclease activity (GO:0004519) 132 0 .04 - < 0.01 1.00E00 1.00E00 nuclease activity (GO:0004518) 215 0 .06 - < 0.01 1.00E00 1.00E00 sodium-dependent organic anion transmembrane transporter activity (GO:0043250) 1 0 .00 - < 0.01 1.00E00 1.00E00 nitric-oxide synthase activity (GO:0004517) 3 0 .00 - < 0.01 1.00E00 1.00E00 nicotinate phosphoribosyltransferase activity (GO:0004516) 1 0 .00 - < 0.01 1.00E00 1.00E00 membrane protein dislocase activity (GO:0140567) 2 0 .00 - < 0.01 1.00E00 1.00E00 nicotinate-nucleotide adenylyltransferase activity (GO:0004515) 4 0 .00 - < 0.01 1.00E00 1.00E00 histone reader activity (GO:0140566) 38 0 .01 - < 0.01 1.00E00 1.00E00 nicotinate-nucleotide diphosphorylase (carboxylating) activity (GO:0004514) 1 0 .00 - < 0.01 1.00E00 1.00E00 AP-3 adaptor complex binding (GO:0035651) 3 0 .00 - < 0.01 1.00E00 1.00E00 AP-1 adaptor complex binding (GO:0035650) 5 0 .00 - < 0.01 1.00E00 1.00E00 inositol-3-phosphate synthase activity (GO:0004512) 1 0 .00 - < 0.01 1.00E00 1.00E00 UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity (GO:0140563) 2 0 .00 - < 0.01 1.00E00 1.00E00 tyrosine 3-monooxygenase activity (GO:0004511) 1 0 .00 - < 0.01 1.00E00 1.00E00 EGF-domain serine xylosyltransferase activity (GO:0140562) 3 0 .00 - < 0.01 1.00E00 1.00E00 tryptophan 5-monooxygenase activity (GO:0004510) 2 0 .00 - < 0.01 1.00E00 1.00E00 acetylputrescine deacetylase activity (GO:0047609) 1 0 .00 - < 0.01 1.00E00 1.00E00 EGF-domain serine glucosyltransferase activity (GO:0140561) 3 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (guanine(7)-N2)-methyltransferase activity (GO:0160118) 1 0 .00 - < 0.01 1.00E00 1.00E00 xylosyl alpha-1,3-xylosyltransferase activity (GO:0140560) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (guanine(6)-N2)-methyltransferase activity (GO:0160117) 1 0 .00 - < 0.01 1.00E00 1.00E00 acetoacetyl-CoA hydrolase activity (GO:0047603) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphorelay sensor kinase activity (GO:0000155) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA strand exchange activity (GO:0000150) 2 0 .00 - < 0.01 1.00E00 1.00E00 steroid 21-monooxygenase activity (GO:0004509) 1 0 .00 - < 0.01 1.00E00 1.00E00 steroid 17-alpha-monooxygenase activity (GO:0004508) 1 0 .00 - < 0.01 1.00E00 1.00E00 steroid 11-beta-monooxygenase activity (GO:0004507) 2 0 .00 - < 0.01 1.00E00 1.00E00 squalene monooxygenase activity (GO:0004506) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-DOPA receptor activity (GO:0035643) 1 0 .00 - < 0.01 1.00E00 1.00E00 phenylalanine 4-monooxygenase activity (GO:0004505) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone H3R17 methyltransferase activity (GO:0035642) 9 0 .00 - < 0.01 1.00E00 1.00E00 peptidylglycine monooxygenase activity (GO:0004504) 1 0 .00 - < 0.01 1.00E00 1.00E00 tyrosinase activity (GO:0004503) 2 0 .00 - < 0.01 1.00E00 1.00E00 kynurenine 3-monooxygenase activity (GO:0004502) 1 0 .00 - < 0.01 1.00E00 1.00E00 dopamine beta-monooxygenase activity (GO:0004500) 3 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (adenine(58)-N1)-methyltransferase activity (GO:0160107) 2 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (adenine(9)-N1)-methyltransferase activity (GO:0160106) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (guanine(26)-N2)-dimethyltransferase activity (GO:0160104) 1 0 .00 - < 0.01 1.00E00 1.00E00 SNARE binding (GO:0000149) 107 0 .03 - < 0.01 1.00E00 1.00E00 tRNA (guanine(10)-N2)-methyltransferase activity (GO:0160102) 1 0 .00 - < 0.01 1.00E00 1.00E00 microfilament motor activity (GO:0000146) 38 0 .01 - < 0.01 1.00E00 1.00E00 acylglycerone-phosphate reductase (NADP+) activity (GO:0000140) 1 0 .00 - < 0.01 1.00E00 1.00E00 laminin-1 binding (GO:0043237) 7 0 .00 - < 0.01 1.00E00 1.00E00 laminin binding (GO:0043236) 29 0 .01 - < 0.01 1.00E00 1.00E00 purine ribonucleoside triphosphate binding (GO:0035639) 1824 0 .53 - < 0.01 1.00E00 1.00E00 ATP-dependent protein disaggregase activity (GO:0140545) 6 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane receptor protein kinase activity (GO:0019199) 78 0 .02 - < 0.01 1.00E00 1.00E00 ATPase-coupled inorganic anion transmembrane transporter activity (GO:0043225) 10 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane receptor protein phosphatase activity (GO:0019198) 17 0 .00 - < 0.01 1.00E00 1.00E00 SMC family protein binding (GO:0043221) 1 0 .00 - < 0.01 1.00E00 1.00E00 transcription regulator activator activity (GO:0140537) 11 0 .00 - < 0.01 1.00E00 1.00E00 small GTPase binding (GO:0031267) 283 0 .08 - < 0.01 1.00E00 1.00E00 glycerol-1-phosphatase activity (GO:0000121) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-1,4-mannosyltransferase activity (GO:0019187) 1 0 .00 - < 0.01 1.00E00 1.00E00 resveratrol binding (GO:1905594) 1 0 .00 - < 0.01 1.00E00 1.00E00 clathrin adaptor activity (GO:0035615) 18 0 .01 - < 0.01 1.00E00 1.00E00 alkanesulfonate binding (GO:0043210) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA stem-loop binding (GO:0035613) 24 0 .01 - < 0.01 1.00E00 1.00E00 AP-2 adaptor complex binding (GO:0035612) 8 0 .00 - < 0.01 1.00E00 1.00E00 GTPase-dependent fusogenic activity (GO:0140523) 1 0 .00 - < 0.01 1.00E00 1.00E00 fusogenic activity (GO:0140522) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycosphingolipid binding (GO:0043208) 10 0 .00 - < 0.01 1.00E00 1.00E00 NADP phosphatase activity (GO:0019178) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-cysteine S-nitrosylase activity (GO:0035605) 3 0 .00 - < 0.01 1.00E00 1.00E00 glyoxalase III activity (GO:0019172) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-RNA adaptor activity (GO:0140517) 23 0 .01 - < 0.01 1.00E00 1.00E00 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity (GO:0019171) 2 0 .00 - < 0.01 1.00E00 1.00E00 denatured protein binding (GO:0031249) 2 0 .00 - < 0.01 1.00E00 1.00E00 succinate dehydrogenase activity (GO:0000104) 3 0 .00 - < 0.01 1.00E00 1.00E00 ganglioside GP1c binding (GO:1905577) 1 0 .00 - < 0.01 1.00E00 1.00E00 ganglioside GT1b binding (GO:1905576) 3 0 .00 - < 0.01 1.00E00 1.00E00 ganglioside GM3 binding (GO:1905575) 1 0 .00 - < 0.01 1.00E00 1.00E00 trans-2-enoyl-CoA reductase (NADPH) activity (GO:0019166) 2 0 .00 - < 0.01 1.00E00 1.00E00 ganglioside GM2 binding (GO:1905574) 1 0 .00 - < 0.01 1.00E00 1.00E00 ganglioside GM1 binding (GO:1905573) 3 0 .00 - < 0.01 1.00E00 1.00E00 endoplasmic reticulum-autophagosome adaptor activity (GO:0140506) 4 0 .00 - < 0.01 1.00E00 1.00E00 N-acylmannosamine kinase activity (GO:0009384) 1 0 .00 - < 0.01 1.00E00 1.00E00 rRNA (cytosine-C5-)-methyltransferase activity (GO:0009383) 3 0 .00 - < 0.01 1.00E00 1.00E00 histamine oxidase activity (GO:0052598) 1 0 .00 - < 0.01 1.00E00 1.00E00 diamine oxidase activity (GO:0052597) 6 0 .00 - < 0.01 1.00E00 1.00E00 aliphatic amine oxidase activity (GO:0052595) 3 0 .00 - < 0.01 1.00E00 1.00E00 mannokinase activity (GO:0019158) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein-disulfide reductase (glutathione) activity (GO:0019153) 2 0 .00 - < 0.01 1.00E00 1.00E00 D-ribulokinase activity (GO:0019150) 1 0 .00 - < 0.01 1.00E00 1.00E00 four-way junction helicase activity (GO:0009378) 48 0 .01 - < 0.01 1.00E00 1.00E00 biotin binding (GO:0009374) 5 0 .00 - < 0.01 1.00E00 1.00E00 maltodextrin phosphorylase activity (GO:0031220) 3 0 .00 - < 0.01 1.00E00 1.00E00 apelin receptor activity (GO:0060182) 1 0 .00 - < 0.01 1.00E00 1.00E00 aminobutyraldehyde dehydrogenase (NAD+) activity (GO:0019145) 2 0 .00 - < 0.01 1.00E00 1.00E00 ADP-sugar diphosphatase activity (GO:0019144) 2 0 .00 - < 0.01 1.00E00 1.00E00 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (GO:0001888) 2 0 .00 - < 0.01 1.00E00 1.00E00 brain-derived neurotrophic factor receptor activity (GO:0060175) 49 0 .01 - < 0.01 1.00E00 1.00E00 phosphatidylcholine binding (GO:0031210) 30 0 .01 - < 0.01 1.00E00 1.00E00 purine nucleoside binding (GO:0001883) 2 0 .00 - < 0.01 1.00E00 1.00E00 nucleoside binding (GO:0001882) 8 0 .00 - < 0.01 1.00E00 1.00E00 deoxynucleoside kinase activity (GO:0019136) 5 0 .00 - < 0.01 1.00E00 1.00E00 deoxyhypusine monooxygenase activity (GO:0019135) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K20 methyltransferase activity (GO:0042799) 9 0 .00 - < 0.01 1.00E00 1.00E00 POZ domain binding (GO:0031208) 4 0 .00 - < 0.01 1.00E00 1.00E00 lipopolysaccharide immune receptor activity (GO:0001875) 6 0 .00 - < 0.01 1.00E00 1.00E00 (1->3)-beta-D-glucan binding (GO:0001872) 2 0 .00 - < 0.01 1.00E00 1.00E00 3'-tRNA processing endoribonuclease activity (GO:0042781) 2 0 .00 - < 0.01 1.00E00 1.00E00 complement component C4b receptor activity (GO:0001861) 1 0 .00 - < 0.01 1.00E00 1.00E00 phenanthrene-9,10-epoxide hydrolase activity (GO:0019119) 1 0 .00 - < 0.01 1.00E00 1.00E00 phenanthrene-epoxide hydrolase activity (GO:0019118) 1 0 .00 - < 0.01 1.00E00 1.00E00 limonene monooxygenase activity (GO:0019113) 2 0 .00 - < 0.01 1.00E00 1.00E00 complement component C4b binding (GO:0001855) 2 0 .00 - < 0.01 1.00E00 1.00E00 complement component C3b binding (GO:0001851) 11 0 .00 - < 0.01 1.00E00 1.00E00 complement component C3a binding (GO:0001850) 1 0 .00 - < 0.01 1.00E00 1.00E00 myristoyltransferase activity (GO:0019107) 11 0 .00 - < 0.01 1.00E00 1.00E00 DNA N-glycosylase activity (GO:0019104) 13 0 .00 - < 0.01 1.00E00 1.00E00 pyrimidine nucleotide binding (GO:0019103) 5 0 .00 - < 0.01 1.00E00 1.00E00 complement component C1q complex binding (GO:0001849) 8 0 .00 - < 0.01 1.00E00 1.00E00 complement binding (GO:0001848) 26 0 .01 - < 0.01 1.00E00 1.00E00 opsonin receptor activity (GO:0001847) 5 0 .00 - < 0.01 1.00E00 1.00E00 opsonin binding (GO:0001846) 21 0 .01 - < 0.01 1.00E00 1.00E00 inorganic triphosphate phosphatase activity (GO:0050355) 1 0 .00 - < 0.01 1.00E00 1.00E00 triokinase activity (GO:0050354) 1 0 .00 - < 0.01 1.00E00 1.00E00 acetyl-CoA binding (GO:1905502) 3 0 .00 - < 0.01 1.00E00 1.00E00 trimethyllysine dioxygenase activity (GO:0050353) 1 0 .00 - < 0.01 1.00E00 1.00E00 membrane insertase activity (GO:0032977) 17 0 .00 - < 0.01 1.00E00 1.00E00 small molecule binding (GO:0036094) 6331 2 1.85 + 1.08 1.00E00 1.00E00 arsenite methyltransferase activity (GO:0030791) 2 0 .00 - < 0.01 1.00E00 1.00E00 trans-L-3-hydroxyproline dehydratase activity (GO:0050346) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-dihydrouridine20b synthase activity (GO:0102267) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-dihydrouridine20a synthase activity (GO:0102266) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-dihydrouridine47 synthase activity (GO:0102265) 1 0 .00 - < 0.01 1.00E00 1.00E00 thymidylate 5'-phosphatase activity (GO:0050340) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-dihydrouridine20 synthase activity (GO:0102264) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-dihydrouridine17 synthase activity (GO:0102263) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-dihydrouridine16 synthase activity (GO:0102262) 1 0 .00 - < 0.01 1.00E00 1.00E00 UDP-glucuronate decarboxylase activity (GO:0048040) 1 0 .00 - < 0.01 1.00E00 1.00E00 purine nucleotide-sugar transmembrane transporter activity (GO:0036080) 2 0 .00 - < 0.01 1.00E00 1.00E00 thiosulfate-thiol sulfurtransferase activity (GO:0050337) 1 0 .00 - < 0.01 1.00E00 1.00E00 ubiquinone binding (GO:0048039) 6 0 .00 - < 0.01 1.00E00 1.00E00 quinone binding (GO:0048038) 17 0 .00 - < 0.01 1.00E00 1.00E00 thiamine triphosphate phosphatase activity (GO:0050333) 1 0 .00 - < 0.01 1.00E00 1.00E00 PH domain binding (GO:0042731) 8 0 .00 - < 0.01 1.00E00 1.00E00 disaccharide binding (GO:0048030) 5 0 .00 - < 0.01 1.00E00 1.00E00 monosaccharide binding (GO:0048029) 74 0 .02 - < 0.01 1.00E00 1.00E00 mRNA 5'-UTR binding (GO:0048027) 24 0 .01 - < 0.01 1.00E00 1.00E00 tau-protein kinase activity (GO:0050321) 10 0 .00 - < 0.01 1.00E00 1.00E00 CCR chemokine receptor binding (GO:0048020) 47 0 .01 - < 0.01 1.00E00 1.00E00 pyridine N-methyltransferase activity (GO:0030760) 1 0 .00 - < 0.01 1.00E00 1.00E00 receptor antagonist activity (GO:0048019) 31 0 .01 - < 0.01 1.00E00 1.00E00 receptor ligand activity (GO:0048018) 545 0 .16 - < 0.01 1.00E00 1.00E00 sulfur dioxygenase activity (GO:0050313) 1 0 .00 - < 0.01 1.00E00 1.00E00 alkane 1-monooxygenase activity (GO:0018685) 5 0 .00 - < 0.01 1.00E00 1.00E00 sterol sensor activity (GO:0032935) 1 0 .00 - < 0.01 1.00E00 1.00E00 11-cis-retinal 3,4-desaturase activity (GO:0061899) 1 0 .00 - < 0.01 1.00E00 1.00E00 sterol binding (GO:0032934) 69 0 .02 - < 0.01 1.00E00 1.00E00 all-trans retinoic acid 3,4-desaturase activity (GO:0061898) 1 0 .00 - < 0.01 1.00E00 1.00E00 all-trans retinal 3,4-desaturase activity (GO:0061897) 1 0 .00 - < 0.01 1.00E00 1.00E00 all-trans retinol 3,4-desaturase activity (GO:0061896) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K56 acetyltransferase activity (GO:0032931) 20 0 .01 - < 0.01 1.00E00 1.00E00 protein-succinyllysine desuccinylase activity (GO:0036055) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein-malonyllysine demalonylase activity (GO:0036054) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcium ion sensor activity (GO:0061891) 22 0 .01 - < 0.01 1.00E00 1.00E00 sugar-terminal-phosphatase activity (GO:0050309) 4 0 .00 - < 0.01 1.00E00 1.00E00 sugar-phosphatase activity (GO:0050308) 12 0 .00 - < 0.01 1.00E00 1.00E00 DNA/RNA hybrid binding (GO:0071667) 5 0 .00 - < 0.01 1.00E00 1.00E00 (S)-limonene 7-monooxygenase activity (GO:0018676) 2 0 .00 - < 0.01 1.00E00 1.00E00 (S)-limonene 6-monooxygenase activity (GO:0018675) 2 0 .00 - < 0.01 1.00E00 1.00E00 orexin receptor activity (GO:0016499) 2 0 .00 - < 0.01 1.00E00 1.00E00 substance K receptor activity (GO:0016497) 1 0 .00 - < 0.01 1.00E00 1.00E00 substance P receptor activity (GO:0016496) 1 0 .00 - < 0.01 1.00E00 1.00E00 C-X3-C chemokine receptor activity (GO:0016495) 1 0 .00 - < 0.01 1.00E00 1.00E00 C-X-C chemokine receptor activity (GO:0016494) 8 0 .00 - < 0.01 1.00E00 1.00E00 S-adenosylmethionine-homocysteine S-methyltransferase activity (GO:0008898) 1 0 .00 - < 0.01 1.00E00 1.00E00 C-C chemokine receptor activity (GO:0016493) 23 0 .01 - < 0.01 1.00E00 1.00E00 holo-[acyl-carrier-protein] synthase activity (GO:0008897) 1 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled neurotensin receptor activity (GO:0016492) 2 0 .00 - < 0.01 1.00E00 1.00E00 amine N-methyltransferase activity (GO:0030748) 1 0 .00 - < 0.01 1.00E00 1.00E00 guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity (GO:0008894) 1 0 .00 - < 0.01 1.00E00 1.00E00 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity (GO:0008893) 1 0 .00 - < 0.01 1.00E00 1.00E00 guanine deaminase activity (GO:0008892) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycine C-acetyltransferase activity (GO:0008890) 1 0 .00 - < 0.01 1.00E00 1.00E00 long-chain fatty acyl-CoA binding (GO:0036042) 4 0 .00 - < 0.01 1.00E00 1.00E00 GTP-dependent protein binding (GO:0030742) 20 0 .01 - < 0.01 1.00E00 1.00E00 long-chain fatty acid binding (GO:0036041) 17 0 .00 - < 0.01 1.00E00 1.00E00 glycerophosphodiester phosphodiesterase activity (GO:0008889) 5 0 .00 - < 0.01 1.00E00 1.00E00 glycerate kinase activity (GO:0008887) 1 0 .00 - < 0.01 1.00E00 1.00E00 carnosine N-methyltransferase activity (GO:0030735) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutamate racemase activity (GO:0008881) 1 0 .00 - < 0.01 1.00E00 1.00E00 mediator complex binding (GO:0036033) 5 0 .00 - < 0.01 1.00E00 1.00E00 guanidinoacetate N-methyltransferase activity (GO:0030731) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucose-1-phosphatase activity (GO:0008877) 2 0 .00 - < 0.01 1.00E00 1.00E00 acetoacetate-CoA ligase activity (GO:0030729) 1 0 .00 - < 0.01 1.00E00 1.00E00 microtubule plus end polymerase (GO:0061863) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA clamp unloader activity (GO:0061860) 2 0 .00 - < 0.01 1.00E00 1.00E00 pyrophosphatase activity (GO:0016462) 805 0 .23 - < 0.01 1.00E00 1.00E00 fructokinase activity (GO:0008865) 5 0 .00 - < 0.01 1.00E00 1.00E00 7-dehydrocholesterol reductase activity (GO:0047598) 1 0 .00 - < 0.01 1.00E00 1.00E00 exoribonuclease II activity (GO:0008859) 3 0 .00 - < 0.01 1.00E00 1.00E00 C-palmitoyltransferase activity (GO:0016454) 5 0 .00 - < 0.01 1.00E00 1.00E00 telomeric G-quadruplex DNA binding (GO:0061849) 2 0 .00 - < 0.01 1.00E00 1.00E00 C-acetyltransferase activity (GO:0016453) 7 0 .00 - < 0.01 1.00E00 1.00E00 protein-glutamine N-methyltransferase activity (GO:0036009) 12 0 .00 - < 0.01 1.00E00 1.00E00 GAF domain binding (GO:0036004) 1 0 .00 - < 0.01 1.00E00 1.00E00 pre-mRNA binding (GO:0036002) 40 0 .01 - < 0.01 1.00E00 1.00E00 N,N-dimethylaniline monooxygenase activity (GO:0004499) 6 0 .00 - < 0.01 1.00E00 1.00E00 calcidiol 1-monooxygenase activity (GO:0004498) 1 0 .00 - < 0.01 1.00E00 1.00E00 monooxygenase activity (GO:0004497) 110 1 .03 + 31.18 3.16E-02 1.00E00 mevalonate kinase activity (GO:0004496) 1 0 .00 - < 0.01 1.00E00 1.00E00 methylmalonyl-CoA mutase activity (GO:0004494) 1 0 .00 - < 0.01 1.00E00 1.00E00 methylmalonyl-CoA epimerase activity (GO:0004493) 1 0 .00 - < 0.01 1.00E00 1.00E00 lysophosphatidylethanolamine acyltransferase activity (GO:0071618) 1 0 .00 - < 0.01 1.00E00 1.00E00 methyl/ethyl malonyl-CoA decarboxylase activity (GO:0004492) 1 0 .00 - < 0.01 1.00E00 1.00E00 lysophospholipid acyltransferase activity (GO:0071617) 23 0 .01 - < 0.01 1.00E00 1.00E00 methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity (GO:0004491) 1 0 .00 - < 0.01 1.00E00 1.00E00 methylglutaconyl-CoA hydratase activity (GO:0004490) 1 0 .00 - < 0.01 1.00E00 1.00E00 linoleic acid epoxygenase activity (GO:0071614) 2 0 .00 - < 0.01 1.00E00 1.00E00 internal mRNA (guanine-N7-)-methyltransferase activity (GO:0160090) 1 0 .00 - < 0.01 1.00E00 1.00E00 endochitinase activity (GO:0008843) 2 0 .00 - < 0.01 1.00E00 1.00E00 methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:0004489) 1 0 .00 - < 0.01 1.00E00 1.00E00 methylenetetrahydrofolate dehydrogenase (NADP+) activity (GO:0004488) 4 0 .00 - < 0.01 1.00E00 1.00E00 methylenetetrahydrofolate dehydrogenase (NAD+) activity (GO:0004487) 3 0 .00 - < 0.01 1.00E00 1.00E00 methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity (GO:0004486) 4 0 .00 - < 0.01 1.00E00 1.00E00 methylcrotonoyl-CoA carboxylase activity (GO:0004485) 2 0 .00 - < 0.01 1.00E00 1.00E00 mRNA guanylyltransferase activity (GO:0004484) 1 0 .00 - < 0.01 1.00E00 1.00E00 mRNA (nucleoside-2'-O-)-methyltransferase activity (GO:0004483) 2 0 .00 - < 0.01 1.00E00 1.00E00 mRNA 5'-cap (guanine-N7-)-methyltransferase activity (GO:0004482) 1 0 .00 - < 0.01 1.00E00 1.00E00 internal N(7)-methylguanine-containing RNA reader activity (GO:0160089) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-queuosine(34) beta-mannosyltransferase activity (GO:0016438) 1 0 .00 - < 0.01 1.00E00 1.00E00 rRNA (uridine) methyltransferase activity (GO:0016436) 4 0 .00 - < 0.01 1.00E00 1.00E00 hypoxia-inducible factor-proline dioxygenase activity (GO:0160082) 4 0 .00 - < 0.01 1.00E00 1.00E00 rRNA (guanine) methyltransferase activity (GO:0016435) 4 0 .00 - < 0.01 1.00E00 1.00E00 iodide channel activity (GO:0160081) 1 0 .00 - < 0.01 1.00E00 1.00E00 rRNA (cytosine) methyltransferase activity (GO:0016434) 5 0 .00 - < 0.01 1.00E00 1.00E00 rRNA (adenine) methyltransferase activity (GO:0016433) 7 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-uridine aminocarboxypropyltransferase activity (GO:0016432) 2 0 .00 - < 0.01 1.00E00 1.00E00 dGTPase activity (GO:0008832) 1 0 .00 - < 0.01 1.00E00 1.00E00 telomeric D-loop binding (GO:0061821) 4 0 .00 - < 0.01 1.00E00 1.00E00 methionyl-tRNA formyltransferase activity (GO:0004479) 1 0 .00 - < 0.01 1.00E00 1.00E00 methionine adenosyltransferase activity (GO:0004478) 2 0 .00 - < 0.01 1.00E00 1.00E00 methenyltetrahydrofolate cyclohydrolase activity (GO:0004477) 3 0 .00 - < 0.01 1.00E00 1.00E00 mannose-6-phosphate isomerase activity (GO:0004476) 1 0 .00 - < 0.01 1.00E00 1.00E00 mannose-1-phosphate guanylyltransferase (GTP) activity (GO:0004475) 1 0 .00 - < 0.01 1.00E00 1.00E00 malate synthase activity (GO:0004474) 1 0 .00 - < 0.01 1.00E00 1.00E00 malate dehydrogenase (decarboxylating) (NADP+) activity (GO:0004473) 3 0 .00 - < 0.01 1.00E00 1.00E00 malate dehydrogenase (decarboxylating) (NAD+) activity (GO:0004471) 1 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled glycine receptor activity (GO:0160079) 1 0 .00 - < 0.01 1.00E00 1.00E00 malic enzyme activity (GO:0004470) 4 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (cytidine-5-)-methyltransferase activity (GO:0016428) 4 0 .00 - < 0.01 1.00E00 1.00E00 4-nitrophenol 2-monooxygenase activity (GO:0018601) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (cytidine) methyltransferase activity (GO:0016427) 9 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (adenine) methyltransferase activity (GO:0016426) 4 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin ligase complex scaffold activity (GO:0160072) 8 0 .00 - < 0.01 1.00E00 1.00E00 dCTP deaminase activity (GO:0008829) 1 0 .00 - < 0.01 1.00E00 1.00E00 dATP diphosphatase activity (GO:0008828) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (guanine) methyltransferase activity (GO:0016423) 12 0 .00 - < 0.01 1.00E00 1.00E00 3-dehydrosphinganine reductase activity (GO:0047560) 1 0 .00 - < 0.01 1.00E00 1.00E00 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity (GO:0016422) 1 0 .00 - < 0.01 1.00E00 1.00E00 CoA carboxylase activity (GO:0016421) 6 0 .00 - < 0.01 1.00E00 1.00E00 malonyltransferase activity (GO:0016420) 2 0 .00 - < 0.01 1.00E00 1.00E00 Met1-linked polyubiquitin deubiquitinase activity (GO:0061815) 1 0 .00 - < 0.01 1.00E00 1.00E00 trimethylamine receptor activity (GO:1990081) 1 0 .00 - < 0.01 1.00E00 1.00E00 cupric reductase (NADH) activity (GO:0008823) 3 0 .00 - < 0.01 1.00E00 1.00E00 crossover junction DNA endonuclease activity (GO:0008821) 7 0 .00 - < 0.01 1.00E00 1.00E00 L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor (GO:0004468) 6 0 .00 - < 0.01 1.00E00 1.00E00 long-chain fatty acid-CoA ligase activity (GO:0004467) 15 0 .00 - < 0.01 1.00E00 1.00E00 long-chain fatty acyl-CoA dehydrogenase activity (GO:0004466) 4 0 .00 - < 0.01 1.00E00 1.00E00 lipoprotein lipase activity (GO:0004465) 13 0 .00 - < 0.01 1.00E00 1.00E00 leukotriene-C4 synthase activity (GO:0004464) 5 0 .00 - < 0.01 1.00E00 1.00E00 leukotriene-A4 hydrolase activity (GO:0004463) 1 0 .00 - < 0.01 1.00E00 1.00E00 lactoylglutathione lyase activity (GO:0004462) 1 0 .00 - < 0.01 1.00E00 1.00E00 lactose synthase activity (GO:0004461) 3 0 .00 - < 0.01 1.00E00 1.00E00 S-malonyltransferase activity (GO:0016419) 2 0 .00 - < 0.01 1.00E00 1.00E00 S-acetyltransferase activity (GO:0016418) 2 0 .00 - < 0.01 1.00E00 1.00E00 3',5'-cyclic-GMP phosphodiesterase activity (GO:0047555) 23 0 .01 - < 0.01 1.00E00 1.00E00 S-acyltransferase activity (GO:0016417) 30 0 .01 - < 0.01 1.00E00 1.00E00 O-palmitoyltransferase activity (GO:0016416) 4 0 .00 - < 0.01 1.00E00 1.00E00 NAD+ nucleosidase activity, cyclic ADP-ribose generating (GO:0061809) 16 0 .00 - < 0.01 1.00E00 1.00E00 O-acetyltransferase activity (GO:0016413) 9 0 .00 - < 0.01 1.00E00 1.00E00 corrinoid adenosyltransferase activity (GO:0008817) 1 0 .00 - < 0.01 1.00E00 1.00E00 serine O-acyltransferase activity (GO:0016412) 1 0 .00 - < 0.01 1.00E00 1.00E00 acylglycerol O-acyltransferase activity (GO:0016411) 31 0 .01 - < 0.01 1.00E00 1.00E00 N-acyltransferase activity (GO:0016410) 92 0 .03 - < 0.01 1.00E00 1.00E00 sulfate binding (GO:0043199) 5 0 .00 - < 0.01 1.00E00 1.00E00 choline dehydrogenase activity (GO:0008812) 1 0 .00 - < 0.01 1.00E00 1.00E00 chloramphenicol O-acetyltransferase activity (GO:0008811) 1 0 .00 - < 0.01 1.00E00 1.00E00 N6-threonylcarbomyladenosine methylthiotransferase activity (GO:0035598) 1 0 .00 - < 0.01 1.00E00 1.00E00 N6-isopentenyladenosine methylthiotransferase activity (GO:0035597) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-lactate dehydrogenase activity (GO:0004459) 5 0 .00 - < 0.01 1.00E00 1.00E00 methylthiotransferase activity (GO:0035596) 2 0 .00 - < 0.01 1.00E00 1.00E00 D-lactate dehydrogenase (cytochrome) activity (GO:0004458) 1 0 .00 - < 0.01 1.00E00 1.00E00 lactate dehydrogenase activity (GO:0004457) 6 0 .00 - < 0.01 1.00E00 1.00E00 ganglioside binding (GO:0035594) 5 0 .00 - < 0.01 1.00E00 1.00E00 ketohexokinase activity (GO:0004454) 1 0 .00 - < 0.01 1.00E00 1.00E00 signaling adaptor activity (GO:0035591) 129 0 .04 - < 0.01 1.00E00 1.00E00 isopentenyl-diphosphate delta-isomerase activity (GO:0004452) 2 0 .00 - < 0.01 1.00E00 1.00E00 isocitrate dehydrogenase (NADP+) activity (GO:0004450) 2 0 .00 - < 0.01 1.00E00 1.00E00 palmitoyltransferase activity (GO:0016409) 36 0 .01 - < 0.01 1.00E00 1.00E00 C-acyltransferase activity (GO:0016408) 20 0 .01 - < 0.01 1.00E00 1.00E00 2-hydroxyglutarate dehydrogenase activity (GO:0047545) 1 0 .00 - < 0.01 1.00E00 1.00E00 sulfur amino acid transmembrane transporter activity (GO:0000099) 11 0 .00 - < 0.01 1.00E00 1.00E00 acetyltransferase activity (GO:0016407) 94 0 .03 - < 0.01 1.00E00 1.00E00 carnitine O-acyltransferase activity (GO:0016406) 5 0 .00 - < 0.01 1.00E00 1.00E00 CoA-ligase activity (GO:0016405) 27 0 .01 - < 0.01 1.00E00 1.00E00 15-hydroxyprostaglandin dehydrogenase (NAD+) activity (GO:0016404) 2 0 .00 - < 0.01 1.00E00 1.00E00 S-adenosyl-L-methionine transmembrane transporter activity (GO:0000095) 1 0 .00 - < 0.01 1.00E00 1.00E00 dimethylargininase activity (GO:0016403) 1 0 .00 - < 0.01 1.00E00 1.00E00 pristanoyl-CoA oxidase activity (GO:0016402) 1 0 .00 - < 0.01 1.00E00 1.00E00 palmitoyl-CoA oxidase activity (GO:0016401) 3 0 .00 - < 0.01 1.00E00 1.00E00 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity (GO:0008803) 1 0 .00 - < 0.01 1.00E00 1.00E00 betaine-aldehyde dehydrogenase (NAD+) activity (GO:0008802) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-lactamase activity (GO:0008800) 4 0 .00 - < 0.01 1.00E00 1.00E00 vascular endothelial growth factor receptor 3 binding (GO:0043185) 2 0 .00 - < 0.01 1.00E00 1.00E00 vascular endothelial growth factor receptor 2 binding (GO:0043184) 9 0 .00 - < 0.01 1.00E00 1.00E00 vascular endothelial growth factor receptor 1 binding (GO:0043183) 3 0 .00 - < 0.01 1.00E00 1.00E00 isocitrate dehydrogenase (NAD+) activity (GO:0004449) 3 0 .00 - < 0.01 1.00E00 1.00E00 isocitrate dehydrogenase [NAD(P)+] activity (GO:0004448) 5 0 .00 - < 0.01 1.00E00 1.00E00 iodide peroxidase activity (GO:0004447) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-hexakisphosphate phosphatase activity (GO:0004446) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-polyphosphate 5-phosphatase activity (GO:0004445) 10 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,4-bisphosphate 1-phosphatase activity (GO:0004441) 2 0 .00 - < 0.01 1.00E00 1.00E00 metal-dependent deubiquitinase activity (GO:0140492) 9 0 .00 - < 0.01 1.00E00 1.00E00 microtubule nucleator activity (GO:0140490) 3 0 .00 - < 0.01 1.00E00 1.00E00 muramyl dipeptide kinase activity (GO:0160047) 1 0 .00 - < 0.01 1.00E00 1.00E00 2-aminoadipate transaminase activity (GO:0047536) 1 0 .00 - < 0.01 1.00E00 1.00E00 C3HC4-type RING finger domain binding (GO:0055131) 5 0 .00 - < 0.01 1.00E00 1.00E00 sulfate:chloride antiporter activity (GO:0160044) 1 0 .00 - < 0.01 1.00E00 1.00E00 purine nucleotide uniporter activity (GO:0160042) 1 0 .00 - < 0.01 1.00E00 1.00E00 neuropeptide activity (GO:0160041) 32 0 .01 - < 0.01 1.00E00 1.00E00 DNA-5-methylcytosine glycosylase activity (GO:1990053) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-1 type II receptor antagonist activity (GO:0045353) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidic acid transfer activity (GO:1990050) 7 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-1 type I receptor antagonist activity (GO:0045352) 1 0 .00 - < 0.01 1.00E00 1.00E00 alcohol binding (GO:0043178) 93 0 .03 - < 0.01 1.00E00 1.00E00 organic acid binding (GO:0043177) 188 0 .05 - < 0.01 1.00E00 1.00E00 amine binding (GO:0043176) 14 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase core enzyme binding (GO:0043175) 42 0 .01 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (GO:0004439) 10 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3-phosphate phosphatase activity (GO:0004438) 17 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K20 demethylase activity (GO:0035575) 4 0 .00 - < 0.01 1.00E00 1.00E00 molecular template activity (GO:0140489) 3 0 .00 - < 0.01 1.00E00 1.00E00 metal ion sequestering activity (GO:0140487) 5 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol phospholipase C activity (GO:0004435) 26 0 .01 - < 0.01 1.00E00 1.00E00 zinc ion sequestering activity (GO:0140486) 2 0 .00 - < 0.01 1.00E00 1.00E00 5-aminolevulinic acid transmembrane transporter activity (GO:0140485) 1 0 .00 - < 0.01 1.00E00 1.00E00 kinetochore adaptor activity (GO:0140483) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-phosphatidylinositol 4-kinase activity (GO:0004430) 4 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type iron-sulfur cluster transporter activity (GO:0140481) 1 0 .00 - < 0.01 1.00E00 1.00E00 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity (GO:0047522) 3 0 .00 - < 0.01 1.00E00 1.00E00 glycerol dehydrogenase [NAD(P)+] activity (GO:1990042) 2 0 .00 - < 0.01 1.00E00 1.00E00 cation binding (GO:0043169) 4468 1 1.30 - .77 1.00E00 1.00E00 anion binding (GO:0043168) 2425 1 .71 + 1.41 5.29E-01 1.00E00 ion binding (GO:0043167) 6133 2 1.79 + 1.12 1.00E00 1.00E00 mercury ion binding (GO:0045340) 3 0 .00 - < 0.01 1.00E00 1.00E00 inorganic diphosphate phosphatase activity (GO:0004427) 5 0 .00 - < 0.01 1.00E00 1.00E00 iduronate-2-sulfatase activity (GO:0004423) 1 0 .00 - < 0.01 1.00E00 1.00E00 hypoxanthine phosphoribosyltransferase activity (GO:0004422) 1 0 .00 - < 0.01 1.00E00 1.00E00 hydroxymethylglutaryl-CoA synthase activity (GO:0004421) 2 0 .00 - < 0.01 1.00E00 1.00E00 hydroxymethylglutaryl-CoA reductase (NADPH) activity (GO:0004420) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-ornithine transmembrane transporter activity (GO:0000064) 5 0 .00 - < 0.01 1.00E00 1.00E00 fatty-acyl-CoA binding (GO:0000062) 15 0 .00 - < 0.01 1.00E00 1.00E00 receptor-receptor interaction (GO:0090722) 4 0 .00 - < 0.01 1.00E00 1.00E00 hydroxymethylglutaryl-CoA lyase activity (GO:0004419) 2 0 .00 - < 0.01 1.00E00 1.00E00 hydroxymethylbilane synthase activity (GO:0004418) 1 0 .00 - < 0.01 1.00E00 1.00E00 hydroxyacylglutathione hydrolase activity (GO:0004416) 3 0 .00 - < 0.01 1.00E00 1.00E00 hyalurononglucosaminidase activity (GO:0004415) 8 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-protein transferase regulator activity (GO:0055106) 36 0 .01 - < 0.01 1.00E00 1.00E00 chromatin-protein adaptor activity (GO:0140463) 49 0 .01 - < 0.01 1.00E00 1.00E00 homogentisate 1,2-dioxygenase activity (GO:0004411) 1 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-protein transferase inhibitor activity (GO:0055105) 15 0 .00 - < 0.01 1.00E00 1.00E00 ligase regulator activity (GO:0055103) 2 0 .00 - < 0.01 1.00E00 1.00E00 deoxynucleoside-phosphate kinase activity, ATP as phosphate donor (GO:0047507) 6 0 .00 - < 0.01 1.00E00 1.00E00 lipase inhibitor activity (GO:0055102) 16 0 .00 - < 0.01 1.00E00 1.00E00 CCACCA tRNA nucleotidyltransferase activity (GO:0160016) 1 0 .00 - < 0.01 1.00E00 1.00E00 deoxyadenylate kinase activity (GO:0047506) 3 0 .00 - < 0.01 1.00E00 1.00E00 adiponectin binding (GO:0055100) 3 0 .00 - < 0.01 1.00E00 1.00E00 NAD-dependent histone decrotonylase activity (GO:0160012) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD-dependent protein decrotonylase activity (GO:0160011) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein de-2-hydroxyisobutyrylase activity (GO:0160010) 2 0 .00 - < 0.01 1.00E00 1.00E00 unmethylated CpG binding (GO:0045322) 10 0 .00 - < 0.01 1.00E00 1.00E00 holocytochrome-c synthase activity (GO:0004408) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone deacetylase activity (GO:0004407) 23 0 .01 - < 0.01 1.00E00 1.00E00 protein demethylase activity (GO:0140457) 31 0 .01 - < 0.01 1.00E00 1.00E00 histone acetyltransferase activity (GO:0004402) 40 0 .01 - < 0.01 1.00E00 1.00E00 histone decrotonylase activity (GO:0160009) 5 0 .00 - < 0.01 1.00E00 1.00E00 protein decrotonylase activity (GO:0160008) 5 0 .00 - < 0.01 1.00E00 1.00E00 poly-ADP-D-ribose modification-dependent protein binding (GO:0160004) 5 0 .00 - < 0.01 1.00E00 1.00E00 tRNA binding (GO:0000049) 81 0 .02 - < 0.01 1.00E00 1.00E00 peptidyltransferase activity (GO:0000048) 2 0 .00 - < 0.01 1.00E00 1.00E00 ADP-D-ribose modification-dependent protein binding (GO:0160002) 7 0 .00 - < 0.01 1.00E00 1.00E00 5'-3' DNA helicase activity (GO:0043139) 9 0 .00 - < 0.01 1.00E00 1.00E00 3'-5' DNA helicase activity (GO:0043138) 48 0 .01 - < 0.01 1.00E00 1.00E00 glycerol-3-phosphatase activity (GO:0043136) 1 0 .00 - < 0.01 1.00E00 1.00E00 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity (GO:0035539) 2 0 .00 - < 0.01 1.00E00 1.00E00 carbohydrate response element binding (GO:0035538) 1 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin binding (GO:0043130) 101 0 .03 - < 0.01 1.00E00 1.00E00 cytoskeleton-nuclear membrane anchor activity (GO:0140444) 5 0 .00 - < 0.01 1.00E00 1.00E00 phosphopantetheine binding (GO:0031177) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein phosphorylated amino acid binding (GO:0045309) 59 0 .02 - < 0.01 1.00E00 1.00E00 acyl carrier activity (GO:0000036) 1 0 .00 - < 0.01 1.00E00 1.00E00 acyl binding (GO:0000035) 2 0 .00 - < 0.01 1.00E00 1.00E00 IDP phosphatase activity (GO:1990003) 4 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,3-mannosyltransferase activity (GO:0000033) 2 0 .00 - < 0.01 1.00E00 1.00E00 methylglyoxal reductase (NADPH) (acetol producing) activity (GO:1990002) 2 0 .00 - < 0.01 1.00E00 1.00E00 mannosyltransferase activity (GO:0000030) 25 0 .01 - < 0.01 1.00E00 1.00E00 ErbB-3 class receptor binding (GO:0043125) 5 0 .00 - < 0.01 1.00E00 1.00E00 NADH pyrophosphatase activity (GO:0035529) 4 0 .00 - < 0.01 1.00E00 1.00E00 neurotrophin binding (GO:0043121) 10 0 .00 - < 0.01 1.00E00 1.00E00 tumor necrosis factor binding (GO:0043120) 7 0 .00 - < 0.01 1.00E00 1.00E00 protein-cysteine S-stearoyltransferase activity (GO:0140439) 7 0 .00 - < 0.01 1.00E00 1.00E00 DNA-(abasic site) binding (GO:0140431) 2 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,2-mannosyltransferase activity (GO:0000026) 4 0 .00 - < 0.01 1.00E00 1.00E00 broad specificity oxidative DNA demethylase activity (GO:0035516) 5 0 .00 - < 0.01 1.00E00 1.00E00 oxidative RNA demethylase activity (GO:0035515) 5 0 .00 - < 0.01 1.00E00 1.00E00 DNA demethylase activity (GO:0035514) 5 0 .00 - < 0.01 1.00E00 1.00E00 lactase activity (GO:0000016) 1 0 .00 - < 0.01 1.00E00 1.00E00 single-stranded DNA endodeoxyribonuclease activity (GO:0000014) 11 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K79 methyltransferase activity (GO:0031151) 1 0 .00 - < 0.01 1.00E00 1.00E00 transcription regulator inhibitor activity (GO:0140416) 36 0 .01 - < 0.01 1.00E00 1.00E00 peroxisome membrane targeting sequence binding (GO:0033328) 2 0 .00 - < 0.01 1.00E00 1.00E00 MH1 domain binding (GO:0035501) 1 0 .00 - < 0.01 1.00E00 1.00E00 MH2 domain binding (GO:0035500) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphopantetheine-dependent carrier activity (GO:0140414) 1 0 .00 - < 0.01 1.00E00 1.00E00 zinc:bicarbonate symporter activity (GO:0140412) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenine phosphoribosyltransferase activity (GO:0003999) 1 0 .00 - < 0.01 1.00E00 1.00E00 acylphosphatase activity (GO:0003998) 2 0 .00 - < 0.01 1.00E00 1.00E00 monoatomic cation:bicarbonate symporter activity (GO:0140410) 13 0 .00 - < 0.01 1.00E00 1.00E00 acyl-CoA oxidase activity (GO:0003997) 6 0 .00 - < 0.01 1.00E00 1.00E00 acyl-CoA dehydrogenase activity (GO:0003995) 12 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,6-mannosyltransferase activity (GO:0000009) 3 0 .00 - < 0.01 1.00E00 1.00E00 aconitate hydratase activity (GO:0003994) 3 0 .00 - < 0.01 1.00E00 1.00E00 acid phosphatase activity (GO:0003993) 9 0 .00 - < 0.01 1.00E00 1.00E00 acetylcholinesterase activity (GO:0003990) 2 0 .00 - < 0.01 1.00E00 1.00E00 acetyl-CoA carboxylase activity (GO:0003989) 2 0 .00 - < 0.01 1.00E00 1.00E00 acetyl-CoA C-acyltransferase activity (GO:0003988) 7 0 .00 - < 0.01 1.00E00 1.00E00 acetate-CoA ligase activity (GO:0003987) 4 0 .00 - < 0.01 1.00E00 1.00E00 acetyl-CoA hydrolase activity (GO:0003986) 4 0 .00 - < 0.01 1.00E00 1.00E00 acetyl-CoA C-acetyltransferase activity (GO:0003985) 6 0 .00 - < 0.01 1.00E00 1.00E00 acetolactate synthase activity (GO:0003984) 1 0 .00 - < 0.01 1.00E00 1.00E00 UTP:glucose-1-phosphate uridylyltransferase activity (GO:0003983) 1 0 .00 - < 0.01 1.00E00 1.00E00 UDP-glucose:glycoprotein glucosyltransferase activity (GO:0003980) 2 0 .00 - < 0.01 1.00E00 1.00E00 molecular adaptor activity (GO:0060090) 1297 0 .38 - < 0.01 1.00E00 1.00E00 nucleobase-containing compound transmembrane transporter activity (GO:0015932) 57 0 .02 - < 0.01 1.00E00 1.00E00 UDP-glucose 6-dehydrogenase activity (GO:0003979) 1 0 .00 - < 0.01 1.00E00 1.00E00 UDP-glucose 4-epimerase activity (GO:0003978) 1 0 .00 - < 0.01 1.00E00 1.00E00 UDP-N-acetylglucosamine diphosphorylase activity (GO:0003977) 2 0 .00 - < 0.01 1.00E00 1.00E00 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity (GO:0003976) 3 0 .00 - < 0.01 1.00E00 1.00E00 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity (GO:0003975) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-(1,2)-fucosyltransferase activity (GO:0031127) 2 0 .00 - < 0.01 1.00E00 1.00E00 dehydroascorbic acid transmembrane transporter activity (GO:0033300) 8 0 .00 - < 0.01 1.00E00 1.00E00 UDP-N-acetylglucosamine 4-epimerase activity (GO:0003974) 1 0 .00 - < 0.01 1.00E00 1.00E00 (S)-2-hydroxy-acid oxidase activity (GO:0003973) 2 0 .00 - < 0.01 1.00E00 1.00E00 molecular transducer activity (GO:0060089) 1563 0 .46 - < 0.01 1.00E00 1.00E00 RNA ligase (ATP) activity (GO:0003972) 1 0 .00 - < 0.01 1.00E00 1.00E00 hexosaminidase activity (GO:0015929) 15 0 .00 - < 0.01 1.00E00 1.00E00 IgM receptor activity (GO:0001793) 1 0 .00 - < 0.01 1.00E00 1.00E00 fucosidase activity (GO:0015928) 2 0 .00 - < 0.01 1.00E00 1.00E00 polymeric immunoglobulin receptor activity (GO:0001792) 1 0 .00 - < 0.01 1.00E00 1.00E00 trehalase activity (GO:0015927) 1 0 .00 - < 0.01 1.00E00 1.00E00 IgM binding (GO:0001791) 3 0 .00 - < 0.01 1.00E00 1.00E00 glucosidase activity (GO:0015926) 14 0 .00 - < 0.01 1.00E00 1.00E00 polymeric immunoglobulin binding (GO:0001790) 2 0 .00 - < 0.01 1.00E00 1.00E00 galactosidase activity (GO:0015925) 7 0 .00 - < 0.01 1.00E00 1.00E00 mannosyl-oligosaccharide mannosidase activity (GO:0015924) 9 0 .00 - < 0.01 1.00E00 1.00E00 mannosidase activity (GO:0015923) 15 0 .00 - < 0.01 1.00E00 1.00E00 RNA-dependent RNA polymerase activity (GO:0003968) 3 0 .00 - < 0.01 1.00E00 1.00E00 RNA-directed DNA polymerase activity (GO:0003964) 18 0 .01 - < 0.01 1.00E00 1.00E00 RNA-3'-phosphate cyclase activity (GO:0003963) 1 0 .00 - < 0.01 1.00E00 1.00E00 NADPH:quinone reductase activity (GO:0003960) 4 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylserine binding (GO:0001786) 59 0 .02 - < 0.01 1.00E00 1.00E00 prostaglandin J receptor activity (GO:0001785) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphotyrosine residue binding (GO:0001784) 47 0 .01 - < 0.01 1.00E00 1.00E00 large conductance calcium-activated potassium channel activity (GO:0060072) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase activity (GO:0097747) 32 0 .01 - < 0.01 1.00E00 1.00E00 protein-containing complex binding (GO:0044877) 1298 0 .38 - < 0.01 1.00E00 1.00E00 steryl-beta-glucosidase activity (GO:0050295) 2 0 .00 - < 0.01 1.00E00 1.00E00 steroid sulfotransferase activity (GO:0050294) 4 0 .00 - < 0.01 1.00E00 1.00E00 sphingosine N-acyltransferase activity (GO:0050291) 7 0 .00 - < 0.01 1.00E00 1.00E00 sphingomyelin phosphodiesterase D activity (GO:0050290) 1 0 .00 - < 0.01 1.00E00 1.00E00 NADPH dehydrogenase activity (GO:0003959) 8 0 .00 - < 0.01 1.00E00 1.00E00 NADPH-hemoprotein reductase activity (GO:0003958) 3 0 .00 - < 0.01 1.00E00 1.00E00 NAD(P)+ transhydrogenase (Si-specific) activity (GO:0003957) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD(P)H dehydrogenase (quinone) activity (GO:0003955) 5 0 .00 - < 0.01 1.00E00 1.00E00 NADH dehydrogenase activity (GO:0003954) 44 0 .01 - < 0.01 1.00E00 1.00E00 NAD+ nucleosidase activity (GO:0003953) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD+ synthase (glutamine-hydrolyzing) activity (GO:0003952) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD+ kinase activity (GO:0003951) 2 0 .00 - < 0.01 1.00E00 1.00E00 NAD+ poly-ADP-ribosyltransferase activity (GO:0003950) 23 0 .01 - < 0.01 1.00E00 1.00E00 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity (GO:0003948) 1 0 .00 - < 0.01 1.00E00 1.00E00 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity (GO:0003947) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetyllactosamine synthase activity (GO:0003945) 5 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity (GO:0003944) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylgalactosamine-4-sulfatase activity (GO:0003943) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-serine ammonia-lyase activity (GO:0003941) 3 0 .00 - < 0.01 1.00E00 1.00E00 L-iduronidase activity (GO:0003940) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-alanine transmembrane transporter activity (GO:0001761) 1 0 .00 - < 0.01 1.00E00 1.00E00 aminocarboxymuconate-semialdehyde decarboxylase activity (GO:0001760) 1 0 .00 - < 0.01 1.00E00 1.00E00 sedoheptulokinase activity (GO:0050277) 1 0 .00 - < 0.01 1.00E00 1.00E00 cortisol dehydrogenase (NAD+) activity (GO:0102196) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-fructosamine 3-kinase activity (GO:0102194) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-ribulosamine 3-kinase activity (GO:0102193) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-iditol 2-dehydrogenase (NAD+) activity (GO:0003939) 1 0 .00 - < 0.01 1.00E00 1.00E00 IMP dehydrogenase activity (GO:0003938) 2 0 .00 - < 0.01 1.00E00 1.00E00 IMP cyclohydrolase activity (GO:0003937) 1 0 .00 - < 0.01 1.00E00 1.00E00 GTP cyclohydrolase I activity (GO:0003934) 1 0 .00 - < 0.01 1.00E00 1.00E00 GTP cyclohydrolase activity (GO:0003933) 1 0 .00 - < 0.01 1.00E00 1.00E00 palmitoyl-CoA 9-desaturase activity (GO:0032896) 1 0 .00 - < 0.01 1.00E00 1.00E00 retinal dehydrogenase activity (GO:0001758) 8 0 .00 - < 0.01 1.00E00 1.00E00 neuropilin binding (GO:0038191) 17 0 .00 - < 0.01 1.00E00 1.00E00 disordered domain specific binding (GO:0097718) 27 0 .01 - < 0.01 1.00E00 1.00E00 RNA uridylyltransferase activity (GO:0050265) 3 0 .00 - < 0.01 1.00E00 1.00E00 GDP binding (GO:0019003) 75 0 .02 - < 0.01 1.00E00 1.00E00 GMP binding (GO:0019002) 2 0 .00 - < 0.01 1.00E00 1.00E00 ribosylnicotinamide kinase activity (GO:0050262) 3 0 .00 - < 0.01 1.00E00 1.00E00 guanyl nucleotide binding (GO:0019001) 404 0 .12 - < 0.01 1.00E00 1.00E00 G protein activity (GO:0003925) 57 0 .02 - < 0.01 1.00E00 1.00E00 GTPase activity (GO:0003924) 333 0 .10 - < 0.01 1.00E00 1.00E00 pattern recognition receptor activity (GO:0038187) 48 0 .01 - < 0.01 1.00E00 1.00E00 peroxynitrite isomerase activity (GO:0062213) 1 0 .00 - < 0.01 1.00E00 1.00E00 GPI-anchor transamidase activity (GO:0003923) 2 0 .00 - < 0.01 1.00E00 1.00E00 bile acid nuclear receptor activity (GO:0038186) 2 0 .00 - < 0.01 1.00E00 1.00E00 GMP synthase (glutamine-hydrolyzing) activity (GO:0003922) 1 0 .00 - < 0.01 1.00E00 1.00E00 GMP synthase activity (GO:0003921) 1 0 .00 - < 0.01 1.00E00 1.00E00 GMP reductase activity (GO:0003920) 2 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled bile acid receptor activity (GO:0038182) 1 0 .00 - < 0.01 1.00E00 1.00E00 ribitol 2-dehydrogenase (NAD+) activity (GO:0050255) 1 0 .00 - < 0.01 1.00E00 1.00E00 rhodopsin kinase activity (GO:0050254) 3 0 .00 - < 0.01 1.00E00 1.00E00 MHC class II protein binding, via antigen binding groove (GO:0042658) 1 0 .00 - < 0.01 1.00E00 1.00E00 retinyl-palmitate esterase activity (GO:0050253) 7 0 .00 - < 0.01 1.00E00 1.00E00 retinol O-fatty-acyltransferase activity (GO:0050252) 3 0 .00 - < 0.01 1.00E00 1.00E00 retinol isomerase activity (GO:0050251) 2 0 .00 - < 0.01 1.00E00 1.00E00 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity (GO:0102175) 1 0 .00 - < 0.01 1.00E00 1.00E00 FMN adenylyltransferase activity (GO:0003919) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (GO:0003918) 3 0 .00 - < 0.01 1.00E00 1.00E00 DNA topoisomerase type I (single strand cut, ATP-independent) activity (GO:0003917) 4 0 .00 - < 0.01 1.00E00 1.00E00 DNA topoisomerase activity (GO:0003916) 7 0 .00 - < 0.01 1.00E00 1.00E00 death receptor agonist activity (GO:0038177) 4 0 .00 - < 0.01 1.00E00 1.00E00 DNA nucleotidylexotransferase activity (GO:0003912) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA ligase (ATP) activity (GO:0003910) 3 0 .00 - < 0.01 1.00E00 1.00E00 prenylcysteine oxidase activity (GO:0001735) 2 0 .00 - < 0.01 1.00E00 1.00E00 mRNA m(6)A methyltransferase activity (GO:0001734) 4 0 .00 - < 0.01 1.00E00 1.00E00 galactosylceramide sulfotransferase activity (GO:0001733) 4 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent (GO:0030697) 2 0 .00 - < 0.01 1.00E00 1.00E00 GTPase regulator activity (GO:0030695) 492 0 .14 - < 0.01 1.00E00 1.00E00 2'-5'-oligoadenylate synthetase activity (GO:0001730) 3 0 .00 - < 0.01 1.00E00 1.00E00 DNA ligase activity (GO:0003909) 3 0 .00 - < 0.01 1.00E00 1.00E00 methylated-DNA-[protein]-cysteine S-methyltransferase activity (GO:0003908) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0003906) 13 0 .00 - < 0.01 1.00E00 1.00E00 alkylbase DNA N-glycosylase activity (GO:0003905) 1 0 .00 - < 0.01 1.00E00 1.00E00 ceramide kinase activity (GO:0001729) 2 0 .00 - < 0.01 1.00E00 1.00E00 thrombopoietin receptor activity (GO:0038164) 1 0 .00 - < 0.01 1.00E00 1.00E00 lipid kinase activity (GO:0001727) 41 0 .01 - < 0.01 1.00E00 1.00E00 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity (GO:0102158) 4 0 .00 - < 0.01 1.00E00 1.00E00 putrescine oxidase activity (GO:0050232) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-amino-acid oxidase activity (GO:0001716) 1 0 .00 - < 0.01 1.00E00 1.00E00 plus-end directed microfilament motor activity (GO:0060002) 3 0 .00 - < 0.01 1.00E00 1.00E00 minus-end directed microfilament motor activity (GO:0060001) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-macromolecule adaptor activity (GO:0030674) 1155 0 .34 - < 0.01 1.00E00 1.00E00 farnesylcysteine lyase activity (GO:0102149) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATPase-coupled transmembrane transporter activity (GO:0042626) 98 0 .03 - < 0.01 1.00E00 1.00E00 prostaglandin E2 9-reductase activity (GO:0050221) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATPase-coupled ion transmembrane transporter activity (GO:0042625) 24 0 .01 - < 0.01 1.00E00 1.00E00 prostaglandin-E synthase activity (GO:0050220) 3 0 .00 - < 0.01 1.00E00 1.00E00 dermatan 2-sulfotransferase activity (GO:0102142) 1 0 .00 - < 0.01 1.00E00 1.00E00 heparan sulfate N-deacetylase activity (GO:0102140) 3 0 .00 - < 0.01 1.00E00 1.00E00 C-X-C motif chemokine 12 receptor activity (GO:0038147) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcitonin binding (GO:0032841) 1 0 .00 - < 0.01 1.00E00 1.00E00 propionate-CoA ligase activity (GO:0050218) 4 0 .00 - < 0.01 1.00E00 1.00E00 procollagen galactosyltransferase activity (GO:0050211) 3 0 .00 - < 0.01 1.00E00 1.00E00 CD8 receptor binding (GO:0042610) 3 0 .00 - < 0.01 1.00E00 1.00E00 cyclic pyranopterin monophosphate synthase activity (GO:0061799) 1 0 .00 - < 0.01 1.00E00 1.00E00 GTP 3',8'-cyclase activity (GO:0061798) 1 0 .00 - < 0.01 1.00E00 1.00E00 neuregulin binding (GO:0038132) 5 0 .00 - < 0.01 1.00E00 1.00E00 pH-gated chloride channel activity (GO:0061797) 2 0 .00 - < 0.01 1.00E00 1.00E00 neuregulin receptor activity (GO:0038131) 3 0 .00 - < 0.01 1.00E00 1.00E00 plasmanylethanolamine desaturase activity (GO:0050207) 1 0 .00 - < 0.01 1.00E00 1.00E00 CD4 receptor binding (GO:0042609) 8 0 .00 - < 0.01 1.00E00 1.00E00 T cell receptor binding (GO:0042608) 11 0 .00 - < 0.01 1.00E00 1.00E00 fucokinase activity (GO:0050201) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptide antigen binding (GO:0042605) 45 0 .01 - < 0.01 1.00E00 1.00E00 UFM1 transferase activity (GO:0071568) 2 0 .00 - < 0.01 1.00E00 1.00E00 deUFMylase activity (GO:0071567) 2 0 .00 - < 0.01 1.00E00 1.00E00 riboflavin reductase (NADPH) activity (GO:0042602) 1 0 .00 - < 0.01 1.00E00 1.00E00 UFM1 activating enzyme activity (GO:0071566) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-aspartyl-peptidase activity (GO:0008798) 2 0 .00 - < 0.01 1.00E00 1.00E00 bis(5'-nucleosyl)-tetraphosphatase activity (GO:0008796) 3 0 .00 - < 0.01 1.00E00 1.00E00 C-C motif chemokine 21 receptor activity (GO:0038121) 1 0 .00 - < 0.01 1.00E00 1.00E00 arsenate reductase (glutaredoxin) activity (GO:0008794) 1 0 .00 - < 0.01 1.00E00 1.00E00 aromatic-amino-acid transaminase activity (GO:0008793) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidoglycan muralytic activity (GO:0061783) 13 0 .00 - < 0.01 1.00E00 1.00E00 arginine decarboxylase activity (GO:0008792) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K27me2/H3K27me3 demethylase activity (GO:0071558) 5 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled pyrimidinergic nucleotide receptor activity (GO:0071553) 4 0 .00 - < 0.01 1.00E00 1.00E00 C-C motif chemokine 19 receptor activity (GO:0038117) 1 0 .00 - < 0.01 1.00E00 1.00E00 tumor necrosis factor receptor superfamily binding (GO:0032813) 50 0 .01 - < 0.01 1.00E00 1.00E00 cohesin loader activity (GO:0061775) 2 0 .00 - < 0.01 1.00E00 1.00E00 sterol response element binding (GO:0032810) 3 0 .00 - < 0.01 1.00E00 1.00E00 agmatinase activity (GO:0008783) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acylneuraminate cytidylyltransferase activity (GO:0008781) 1 0 .00 - < 0.01 1.00E00 1.00E00 translation elongation factor binding (GO:0061770) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein carboxyl O-methyltransferase activity (GO:0051998) 6 0 .00 - < 0.01 1.00E00 1.00E00 squalene synthase [NAD(P)H] activity (GO:0051996) 1 0 .00 - < 0.01 1.00E00 1.00E00 (R)-2-hydroxyglutarate dehydrogenase activity (GO:0051990) 1 0 .00 - < 0.01 1.00E00 1.00E00 homocarnosine synthase activity (GO:0102102) 1 0 .00 - < 0.01 1.00E00 1.00E00 choriogonadotropin hormone binding (GO:0038106) 1 0 .00 - < 0.01 1.00E00 1.00E00 ribosylnicotinate kinase activity (GO:0061769) 3 0 .00 - < 0.01 1.00E00 1.00E00 magnesium:sodium antiporter activity (GO:0061768) 2 0 .00 - < 0.01 1.00E00 1.00E00 activin receptor antagonist activity (GO:0038102) 2 0 .00 - < 0.01 1.00E00 1.00E00 U6 snRNA 3'-end binding (GO:0030629) 2 0 .00 - < 0.01 1.00E00 1.00E00 acetate CoA-transferase activity (GO:0008775) 1 0 .00 - < 0.01 1.00E00 1.00E00 pre-mRNA 3'-splice site binding (GO:0030628) 6 0 .00 - < 0.01 1.00E00 1.00E00 nodal binding (GO:0038100) 5 0 .00 - < 0.01 1.00E00 1.00E00 pre-mRNA 5'-splice site binding (GO:0030627) 2 0 .00 - < 0.01 1.00E00 1.00E00 U12 snRNA binding (GO:0030626) 2 0 .00 - < 0.01 1.00E00 1.00E00 U6atac snRNA binding (GO:0030624) 1 0 .00 - < 0.01 1.00E00 1.00E00 U5 snRNA binding (GO:0030623) 3 0 .00 - < 0.01 1.00E00 1.00E00 U4atac snRNA binding (GO:0030622) 3 0 .00 - < 0.01 1.00E00 1.00E00 U4 snRNA binding (GO:0030621) 6 0 .00 - < 0.01 1.00E00 1.00E00 U2 snRNA binding (GO:0030620) 6 0 .00 - < 0.01 1.00E00 1.00E00 methanethiol oxidase activity (GO:0018549) 1 0 .00 - < 0.01 1.00E00 1.00E00 RING-like zinc finger domain binding (GO:0071535) 3 0 .00 - < 0.01 1.00E00 1.00E00 ankyrin repeat binding (GO:0071532) 6 0 .00 - < 0.01 1.00E00 1.00E00 UDP-sugar diphosphatase activity (GO:0008768) 2 0 .00 - < 0.01 1.00E00 1.00E00 activin receptor activity, type II (GO:0016362) 12 0 .00 - < 0.01 1.00E00 1.00E00 activin receptor activity, type I (GO:0016361) 12 0 .00 - < 0.01 1.00E00 1.00E00 U1 snRNA binding (GO:0030619) 7 0 .00 - < 0.01 1.00E00 1.00E00 telomeric repeat-containing RNA binding (GO:0061752) 2 0 .00 - < 0.01 1.00E00 1.00E00 UDP-N-acetylglucosamine 2-epimerase activity (GO:0008761) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor (GO:0030614) 3 0 .00 - < 0.01 1.00E00 1.00E00 neutral sphingomyelin phosphodiesterase activity (GO:0061751) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on phosphorus or arsenic in donors (GO:0030613) 3 0 .00 - < 0.01 1.00E00 1.00E00 acid sphingomyelin phosphodiesterase activity (GO:0061750) 1 0 .00 - < 0.01 1.00E00 1.00E00 arsenate reductase activity (GO:0030611) 1 0 .00 - < 0.01 1.00E00 1.00E00 lysophospholipid:sodium symporter activity (GO:0051978) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcium-independent phospholipase A2 activity (GO:0047499) 9 0 .00 - < 0.01 1.00E00 1.00E00 calcium-dependent phospholipase A2 activity (GO:0047498) 17 0 .00 - < 0.01 1.00E00 1.00E00 ceramide cholinephosphotransferase activity (GO:0047493) 3 0 .00 - < 0.01 1.00E00 1.00E00 forked DNA-dependent helicase activity (GO:0061749) 47 0 .01 - < 0.01 1.00E00 1.00E00 S-adenosylmethionine-dependent methyltransferase activity (GO:0008757) 168 0 .05 - < 0.01 1.00E00 1.00E00 NADPH dehydrogenase (quinone) activity (GO:0008753) 4 0 .00 - < 0.01 1.00E00 1.00E00 proton-translocating NAD(P)+ transhydrogenase activity (GO:0008750) 1 0 .00 - < 0.01 1.00E00 1.00E00 histidine decarboxylase activity (GO:0004398) 1 0 .00 - < 0.01 1.00E00 1.00E00 histidine ammonia-lyase activity (GO:0004397) 1 0 .00 - < 0.01 1.00E00 1.00E00 hexokinase activity (GO:0004396) 5 0 .00 - < 0.01 1.00E00 1.00E00 heparan sulfate 2-sulfotransferase activity (GO:0004394) 1 0 .00 - < 0.01 1.00E00 1.00E00 heme oxygenase (decyclizing) activity (GO:0004392) 2 0 .00 - < 0.01 1.00E00 1.00E00 MCM complex binding (GO:1904931) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylneuraminate lyase activity (GO:0008747) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylmuramoyl-L-alanine amidase activity (GO:0008745) 4 0 .00 - < 0.01 1.00E00 1.00E00 protein-lysine-acetyltransferase activity (GO:0061733) 45 0 .01 - < 0.01 1.00E00 1.00E00 ribonucleoside-diphosphate reductase activity (GO:0061731) 3 0 .00 - < 0.01 1.00E00 1.00E00 dynein light intermediate chain binding (GO:0051959) 28 0 .01 - < 0.01 1.00E00 1.00E00 helicase activity (GO:0004386) 155 0 .05 - < 0.01 1.00E00 1.00E00 guanylate kinase activity (GO:0004385) 9 0 .00 - < 0.01 1.00E00 1.00E00 guanylate cyclase activity (GO:0004383) 9 0 .00 - < 0.01 1.00E00 1.00E00 gap junction hemi-channel activity (GO:0055077) 4 0 .00 - < 0.01 1.00E00 1.00E00 GDP phosphatase activity (GO:0004382) 10 0 .00 - < 0.01 1.00E00 1.00E00 fucosylgalactoside 3-alpha-galactosyltransferase activity (GO:0004381) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity (GO:0004380) 1 0 .00 - < 0.01 1.00E00 1.00E00 cadherin binding (GO:0045296) 325 0 .09 - < 0.01 1.00E00 1.00E00 gamma-catenin binding (GO:0045295) 12 0 .00 - < 0.01 1.00E00 1.00E00 alpha-catenin binding (GO:0045294) 11 0 .00 - < 0.01 1.00E00 1.00E00 L-allo-threonine aldolase activity (GO:0008732) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycylpeptide N-tetradecanoyltransferase activity (GO:0004379) 2 0 .00 - < 0.01 1.00E00 1.00E00 GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity (GO:0004378) 1 0 .00 - < 0.01 1.00E00 1.00E00 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity (GO:0004377) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycolipid mannosyltransferase activity (GO:0004376) 5 0 .00 - < 0.01 1.00E00 1.00E00 glycine dehydrogenase (decarboxylating) activity (GO:0004375) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity (GO:0004373) 3 0 .00 - < 0.01 1.00E00 1.00E00 glycine hydroxymethyltransferase activity (GO:0004372) 2 0 .00 - < 0.01 1.00E00 1.00E00 glycerone kinase activity (GO:0004371) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycerol kinase activity (GO:0004370) 4 0 .00 - < 0.01 1.00E00 1.00E00 Ser-tRNA(Ala) hydrolase activity (GO:0002196) 2 0 .00 - < 0.01 1.00E00 1.00E00 heparosan-N-sulfate-glucuronate 5-epimerase activity (GO:0047464) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-3-methyladenine glycosylase activity (GO:0008725) 1 0 .00 - < 0.01 1.00E00 1.00E00 folic acid receptor activity (GO:0061714) 2 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase (GO:0061712) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-serine ammonia-lyase activity (GO:0008721) 1 0 .00 - < 0.01 1.00E00 1.00E00 N(6)-L-threonylcarbamoyladenine synthase activity (GO:0061711) 2 0 .00 - < 0.01 1.00E00 1.00E00 D-lactate dehydrogenase activity (GO:0008720) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-threonylcarbamoyladenylate synthase (GO:0061710) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycerol-3-phosphate dehydrogenase (quinone) activity (GO:0004368) 2 0 .00 - < 0.01 1.00E00 1.00E00 glycerol-3-phosphate O-acyltransferase activity (GO:0004366) 4 0 .00 - < 0.01 1.00E00 1.00E00 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity (GO:0004365) 2 0 .00 - < 0.01 1.00E00 1.00E00 glutathione transferase activity (GO:0004364) 27 0 .01 - < 0.01 1.00E00 1.00E00 glutathione synthase activity (GO:0004363) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-glucose transmembrane transporter activity (GO:0055056) 22 0 .01 - < 0.01 1.00E00 1.00E00 glutathione-disulfide reductase (NADPH) activity (GO:0004362) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutaryl-CoA dehydrogenase activity (GO:0004361) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutamine-fructose-6-phosphate transaminase (isomerizing) activity (GO:0004360) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity (GO:0016316) 2 0 .00 - < 0.01 1.00E00 1.00E00 ATP-dependent NAD(P)H-hydrate dehydratase activity (GO:0047453) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity (GO:0016314) 6 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-5-taurinomethyluridine 2-sulfurtransferase (GO:0061708) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol bisphosphate phosphatase activity (GO:0016312) 7 0 .00 - < 0.01 1.00E00 1.00E00 cAMP response element binding (GO:0035497) 12 0 .00 - < 0.01 1.00E00 1.00E00 glutaminase activity (GO:0004359) 4 0 .00 - < 0.01 1.00E00 1.00E00 glutamate-cysteine ligase activity (GO:0004357) 2 0 .00 - < 0.01 1.00E00 1.00E00 glutamine synthetase activity (GO:0004356) 1 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol sulfotransferase activity (GO:0051922) 2 0 .00 - < 0.01 1.00E00 1.00E00 glutamate dehydrogenase (NADP+) activity (GO:0004354) 2 0 .00 - < 0.01 1.00E00 1.00E00 glutamate dehydrogenase [NAD(P)+] activity (GO:0004353) 2 0 .00 - < 0.01 1.00E00 1.00E00 peroxiredoxin activity (GO:0051920) 8 0 .00 - < 0.01 1.00E00 1.00E00 glutamate dehydrogenase (NAD+) activity (GO:0004352) 2 0 .00 - < 0.01 1.00E00 1.00E00 glutamate decarboxylase activity (GO:0004351) 2 0 .00 - < 0.01 1.00E00 1.00E00 glutamate-5-semialdehyde dehydrogenase activity (GO:0004350) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-phosphatidylinositol-5-phosphate 4-kinase activity (GO:0016309) 3 0 .00 - < 0.01 1.00E00 1.00E00 1-phosphatidylinositol-4-phosphate 5-kinase activity (GO:0016308) 9 0 .00 - < 0.01 1.00E00 1.00E00 N-acylneuraminate-9-phosphate synthase activity (GO:0047444) 1 0 .00 - < 0.01 1.00E00 1.00E00 high-affinity IgM receptor activity (GO:0002172) 1 0 .00 - < 0.01 1.00E00 1.00E00 cholate 7-alpha-dehydrogenase (NAD+) activity (GO:0008709) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-phosphatidylinositol-3-kinase activity (GO:0016303) 10 0 .00 - < 0.01 1.00E00 1.00E00 4-phytase activity (GO:0008707) 1 0 .00 - < 0.01 1.00E00 1.00E00 kinase activity (GO:0016301) 725 0 .21 - < 0.01 1.00E00 1.00E00 tRNA (uridine) methyltransferase activity (GO:0016300) 5 0 .00 - < 0.01 1.00E00 1.00E00 methionine synthase activity (GO:0008705) 1 0 .00 - < 0.01 1.00E00 1.00E00 (R,S)-4-hydroxy-2-oxoglutarate aldolase activity (GO:0008700) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutamate 5-kinase activity (GO:0004349) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenine/guanine mispair binding (GO:0035485) 1 0 .00 - < 0.01 1.00E00 1.00E00 granulocyte colony-stimulating factor binding (GO:0051916) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucosylceramidase activity (GO:0004348) 4 0 .00 - < 0.01 1.00E00 1.00E00 glucose-6-phosphate isomerase activity (GO:0004347) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucose-6-phosphatase activity (GO:0004346) 4 0 .00 - < 0.01 1.00E00 1.00E00 glucose-6-phosphate dehydrogenase activity (GO:0004345) 2 0 .00 - < 0.01 1.00E00 1.00E00 glucose dehydrogenase activity (GO:0004344) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucosamine 6-phosphate N-acetyltransferase activity (GO:0004343) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucosamine-6-phosphate deaminase activity (GO:0004342) 2 0 .00 - < 0.01 1.00E00 1.00E00 gluconolactonase activity (GO:0004341) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucokinase activity (GO:0004340) 5 0 .00 - < 0.01 1.00E00 1.00E00 dystroglycan binding (GO:0002162) 11 0 .00 - < 0.01 1.00E00 1.00E00 aminoacyl-tRNA editing activity (GO:0002161) 13 0 .00 - < 0.01 1.00E00 1.00E00 chylomicron binding (GO:0035478) 1 0 .00 - < 0.01 1.00E00 1.00E00 double-stranded DNA 5'-3' DNA exonuclease activity (GO:0051908) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucan 1,4-alpha-glucosidase activity (GO:0004339) 2 0 .00 - < 0.01 1.00E00 1.00E00 (2E,6E)-farnesyl diphosphate synthase activity (GO:0004337) 2 0 .00 - < 0.01 1.00E00 1.00E00 lipase binding (GO:0035473) 7 0 .00 - < 0.01 1.00E00 1.00E00 galactosylceramidase activity (GO:0004336) 5 0 .00 - < 0.01 1.00E00 1.00E00 choriogonadotropin hormone receptor activity (GO:0035472) 1 0 .00 - < 0.01 1.00E00 1.00E00 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity (GO:0051903) 2 0 .00 - < 0.01 1.00E00 1.00E00 galactokinase activity (GO:0004335) 2 0 .00 - < 0.01 1.00E00 1.00E00 fumarylacetoacetase activity (GO:0004334) 1 0 .00 - < 0.01 1.00E00 1.00E00 fumarate hydratase activity (GO:0004333) 1 0 .00 - < 0.01 1.00E00 1.00E00 fructose-bisphosphate aldolase activity (GO:0004332) 3 0 .00 - < 0.01 1.00E00 1.00E00 fructose-2,6-bisphosphate 2-phosphatase activity (GO:0004331) 5 0 .00 - < 0.01 1.00E00 1.00E00 nucleoside triphosphate diphosphatase activity (GO:0047429) 10 0 .00 - < 0.01 1.00E00 1.00E00 monocarboxylic acid binding (GO:0033293) 79 0 .02 - < 0.01 1.00E00 1.00E00 steroid receptor RNA activator RNA binding (GO:0002153) 2 0 .00 - < 0.01 1.00E00 1.00E00 G-quadruplex RNA binding (GO:0002151) 8 0 .00 - < 0.01 1.00E00 1.00E00 formate-tetrahydrofolate ligase activity (GO:0004329) 2 0 .00 - < 0.01 1.00E00 1.00E00 tetrahydrofolylpolyglutamate synthase activity (GO:0004326) 1 0 .00 - < 0.01 1.00E00 1.00E00 ferrochelatase activity (GO:0004325) 1 0 .00 - < 0.01 1.00E00 1.00E00 immune receptor activity (GO:0140375) 156 0 .05 - < 0.01 1.00E00 1.00E00 ferredoxin-NADP+ reductase activity (GO:0004324) 1 0 .00 - < 0.01 1.00E00 1.00E00 ferroxidase activity (GO:0004322) 6 0 .00 - < 0.01 1.00E00 1.00E00 ATPase-coupled monocarboxylic acid transmembrane transporter activity (GO:0033285) 4 0 .00 - < 0.01 1.00E00 1.00E00 fatty-acyl-CoA synthase activity (GO:0004321) 7 0 .00 - < 0.01 1.00E00 1.00E00 ATPase-coupled carboxylic acid transmembrane transporter activity (GO:0033284) 4 0 .00 - < 0.01 1.00E00 1.00E00 ATPase-coupled organic acid transmembrane transporter activity (GO:0033283) 4 0 .00 - < 0.01 1.00E00 1.00E00 N-(long-chain-acyl)ethanolamine deacylase activity (GO:0047412) 1 0 .00 - < 0.01 1.00E00 1.00E00 CXCR1 chemokine receptor binding (GO:0045237) 1 0 .00 - < 0.01 1.00E00 1.00E00 CXCR chemokine receptor binding (GO:0045236) 17 0 .00 - < 0.01 1.00E00 1.00E00 endoribonuclease activity, cleaving miRNA-paired mRNA (GO:0090624) 2 0 .00 - < 0.01 1.00E00 1.00E00 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity (GO:0004316) 2 0 .00 - < 0.01 1.00E00 1.00E00 3-oxoacyl-[acyl-carrier-protein] synthase activity (GO:0004315) 2 0 .00 - < 0.01 1.00E00 1.00E00 [acyl-carrier-protein] S-malonyltransferase activity (GO:0004314) 2 0 .00 - < 0.01 1.00E00 1.00E00 [acyl-carrier-protein] S-acetyltransferase activity (GO:0004313) 1 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid synthase activity (GO:0004312) 1 0 .00 - < 0.01 1.00E00 1.00E00 geranylgeranyl diphosphate synthase activity (GO:0004311) 2 0 .00 - < 0.01 1.00E00 1.00E00 alkenylglycerophosphocholine hydrolase activity (GO:0047408) 2 0 .00 - < 0.01 1.00E00 1.00E00 cyclic-GMP-AMP transmembrane transporter activity (GO:0140360) 3 0 .00 - < 0.01 1.00E00 1.00E00 ADP-ribosyl-[dinitrogen reductase] hydrolase activity (GO:0047407) 1 0 .00 - < 0.01 1.00E00 1.00E00 CTP binding (GO:0002135) 1 0 .00 - < 0.01 1.00E00 1.00E00 UTP binding (GO:0002134) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein-glucosylgalactosylhydroxylysine glucosidase activity (GO:0047402) 1 0 .00 - < 0.01 1.00E00 1.00E00 single-stranded telomeric DNA binding (GO:0043047) 12 0 .00 - < 0.01 1.00E00 1.00E00 exopolyphosphatase activity (GO:0004309) 1 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type transporter activity (GO:0140359) 48 0 .01 - < 0.01 1.00E00 1.00E00 exo-alpha-sialidase activity (GO:0004308) 4 0 .00 - < 0.01 1.00E00 1.00E00 P-type transmembrane transporter activity (GO:0140358) 25 0 .01 - < 0.01 1.00E00 1.00E00 ethanolaminephosphotransferase activity (GO:0004307) 3 0 .00 - < 0.01 1.00E00 1.00E00 ethanolamine-phosphate cytidylyltransferase activity (GO:0004306) 1 0 .00 - < 0.01 1.00E00 1.00E00 ethanolamine kinase activity (GO:0004305) 4 0 .00 - < 0.01 1.00E00 1.00E00 cargo receptor ligand activity (GO:0140355) 3 0 .00 - < 0.01 1.00E00 1.00E00 estrone sulfotransferase activity (GO:0004304) 1 0 .00 - < 0.01 1.00E00 1.00E00 choline binding (GO:0033265) 4 0 .00 - < 0.01 1.00E00 1.00E00 epoxide hydrolase activity (GO:0004301) 8 0 .00 - < 0.01 1.00E00 1.00E00 glycosylceramide flippase activity (GO:0140351) 3 0 .00 - < 0.01 1.00E00 1.00E00 enoyl-CoA hydratase activity (GO:0004300) 12 0 .00 - < 0.01 1.00E00 1.00E00 chromatin insulator sequence binding (GO:0043035) 5 0 .00 - < 0.01 1.00E00 1.00E00 cyclic-di-GMP binding (GO:0035438) 1 0 .00 - < 0.01 1.00E00 1.00E00 lysophosphatidylcholine flippase activity (GO:0140348) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-retinylidene-phosphatidylethanolamine flippase activity (GO:0140347) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylserine flippase activity (GO:0140346) 5 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylcholine flippase activity (GO:0140345) 5 0 .00 - < 0.01 1.00E00 1.00E00 triglyceride transfer activity (GO:0140344) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylserine transfer activity (GO:0140343) 2 0 .00 - < 0.01 1.00E00 1.00E00 cerebroside transfer activity (GO:0140340) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-33 receptor activity (GO:0002114) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K14 deacetylase activity, hydrolytic mechanism (GO:0031078) 10 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-33 binding (GO:0002113) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-33 receptor binding (GO:0002112) 1 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol 26-hydroxylase activity (GO:0031073) 1 0 .00 - < 0.01 1.00E00 1.00E00 heat shock protein binding (GO:0031072) 131 0 .04 - < 0.01 1.00E00 1.00E00 cysteine desulfurase activity (GO:0031071) 1 0 .00 - < 0.01 1.00E00 1.00E00 cysteine-type endopeptidase regulator activity involved in apoptotic process (GO:0043028) 31 0 .01 - < 0.01 1.00E00 1.00E00 cysteine-type endopeptidase inhibitor activity involved in apoptotic process (GO:0043027) 16 0 .00 - < 0.01 1.00E00 1.00E00 ribosomal small subunit binding (GO:0043024) 20 0 .01 - < 0.01 1.00E00 1.00E00 ribosomal large subunit binding (GO:0043023) 17 0 .00 - < 0.01 1.00E00 1.00E00 ribosome binding (GO:0043022) 112 0 .03 - < 0.01 1.00E00 1.00E00 ribonucleoprotein complex binding (GO:0043021) 176 0 .05 - < 0.01 1.00E00 1.00E00 phosphatidylglycerol transfer activity (GO:0140339) 1 0 .00 - < 0.01 1.00E00 1.00E00 sphingomyelin transfer activity (GO:0140338) 2 0 .00 - < 0.01 1.00E00 1.00E00 diacylglyceride transfer activity (GO:0140337) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycerophospholipid flippase activity (GO:0140333) 13 0 .00 - < 0.01 1.00E00 1.00E00 gamma-tubulin binding (GO:0043015) 37 0 .01 - < 0.01 1.00E00 1.00E00 alpha-tubulin binding (GO:0043014) 46 0 .01 - < 0.01 1.00E00 1.00E00 retromer complex binding (GO:1905394) 10 0 .00 - < 0.01 1.00E00 1.00E00 iron ion transmembrane transporter inhibitor activity (GO:0097690) 1 0 .00 - < 0.01 1.00E00 1.00E00 floppase activity (GO:0140328) 16 0 .00 - < 0.01 1.00E00 1.00E00 flippase activity (GO:0140327) 16 0 .00 - < 0.01 1.00E00 1.00E00 ATPase-coupled intramembrane lipid transporter activity (GO:0140326) 27 0 .01 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor (GO:0046997) 2 0 .00 - < 0.01 1.00E00 1.00E00 ATP-dependent protein binding (GO:0043008) 6 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond (GO:0046992) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-hydroxyarylamine O-acetyltransferase activity (GO:0046990) 1 0 .00 - < 0.01 1.00E00 1.00E00 intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity (GO:0097682) 3 0 .00 - < 0.01 1.00E00 1.00E00 receptor decoy activity (GO:0140319) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein transporter activity (GO:0140318) 42 0 .01 - < 0.01 1.00E00 1.00E00 histone H3T6 kinase activity (GO:0035403) 246 0 .07 - < 0.01 1.00E00 1.00E00 cysteine transmembrane transporter activity (GO:0033229) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone H3T11 kinase activity (GO:0035402) 246 0 .07 - < 0.01 1.00E00 1.00E00 iron ion sequestering activity (GO:0140315) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H3Y41 kinase activity (GO:0035401) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcium ion sequestering activity (GO:0140314) 1 0 .00 - < 0.01 1.00E00 1.00E00 molecular sequestering activity (GO:0140313) 59 0 .02 - < 0.01 1.00E00 1.00E00 anandamide 14,15 epoxidase activity (GO:0062189) 4 0 .00 - < 0.01 1.00E00 1.00E00 cargo adaptor activity (GO:0140312) 21 0 .01 - < 0.01 1.00E00 1.00E00 anandamide 11,12 epoxidase activity (GO:0062188) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein sequestering activity (GO:0140311) 36 0 .01 - < 0.01 1.00E00 1.00E00 DNA-directed 5'-3' RNA polymerase activity (GO:0003899) 30 0 .01 - < 0.01 1.00E00 1.00E00 anandamide 8,9 epoxidase activity (GO:0062187) 3 0 .00 - < 0.01 1.00E00 1.00E00 anandamide epoxidase activity (GO:0062186) 4 0 .00 - < 0.01 1.00E00 1.00E00 secalciferol 1-monooxygenase activity (GO:0062185) 1 0 .00 - < 0.01 1.00E00 1.00E00 testosterone 16-beta-hydroxylase activity (GO:0062184) 2 0 .00 - < 0.01 1.00E00 1.00E00 all-trans retinoic acid 18-hydroxylase activity (GO:0062183) 3 0 .00 - < 0.01 1.00E00 1.00E00 all-trans retinoic acid 4-hydrolase activity (GO:0062182) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity (GO:0062181) 2 0 .00 - < 0.01 1.00E00 1.00E00 25-hydroxycholecalciferol-23-hydroxylase activity (GO:0062180) 1 0 .00 - < 0.01 1.00E00 1.00E00 STAT family protein binding (GO:0097677) 12 0 .00 - < 0.01 1.00E00 1.00E00 protein dimerization activity (GO:0046983) 1094 1 .32 + 3.14 2.79E-01 1.00E00 protein heterodimerization activity (GO:0046982) 338 0 .10 - < 0.01 1.00E00 1.00E00 tapasin binding (GO:0046980) 1 0 .00 - < 0.01 1.00E00 1.00E00 amide binding (GO:0033218) 244 0 .07 - < 0.01 1.00E00 1.00E00 intramembrane lipid transporter activity (GO:0140303) 48 0 .01 - < 0.01 1.00E00 1.00E00 vitamin D 23-hydroxylase activity (GO:0062179) 2 0 .00 - < 0.01 1.00E00 1.00E00 DNA-directed DNA polymerase activity (GO:0003887) 24 0 .01 - < 0.01 1.00E00 1.00E00 DNA (cytosine-5-)-methyltransferase activity (GO:0003886) 3 0 .00 - < 0.01 1.00E00 1.00E00 D-amino-acid oxidase activity (GO:0003884) 2 0 .00 - < 0.01 1.00E00 1.00E00 CTP synthase activity (GO:0003883) 2 0 .00 - < 0.01 1.00E00 1.00E00 CDP-diacylglycerol-serine O-phosphatidyltransferase activity (GO:0003882) 1 0 .00 - < 0.01 1.00E00 1.00E00 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity (GO:0003881) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein C-terminal carboxyl O-methyltransferase activity (GO:0003880) 2 0 .00 - < 0.01 1.00E00 1.00E00 TAP2 binding (GO:0046979) 3 0 .00 - < 0.01 1.00E00 1.00E00 TAP1 binding (GO:0046978) 4 0 .00 - < 0.01 1.00E00 1.00E00 TAP binding (GO:0046977) 7 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K27 methyltransferase activity (GO:0046976) 6 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K36 methyltransferase activity (GO:0046975) 13 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K9 methyltransferase activity (GO:0046974) 13 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K16 acetyltransferase activity (GO:0046972) 22 0 .01 - < 0.01 1.00E00 1.00E00 histone H4K16 deacetylase activity, NAD-dependent (GO:0046970) 5 0 .00 - < 0.01 1.00E00 1.00E00 ribonuclease P RNA binding (GO:0033204) 10 0 .00 - < 0.01 1.00E00 1.00E00 ATP citrate synthase activity (GO:0003878) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATP:ADP adenylyltransferase activity (GO:0003877) 1 0 .00 - < 0.01 1.00E00 1.00E00 AMP deaminase activity (GO:0003876) 3 0 .00 - < 0.01 1.00E00 1.00E00 ADP-ribosylarginine hydrolase activity (GO:0003875) 2 0 .00 - < 0.01 1.00E00 1.00E00 6-pyruvoyltetrahydropterin synthase activity (GO:0003874) 1 0 .00 - < 0.01 1.00E00 1.00E00 6-phosphofructo-2-kinase activity (GO:0003873) 4 0 .00 - < 0.01 1.00E00 1.00E00 6-phosphofructokinase activity (GO:0003872) 3 0 .00 - < 0.01 1.00E00 1.00E00 5-aminolevulinate synthase activity (GO:0003870) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K9 deacetylase activity, NAD-dependent (GO:0046969) 5 0 .00 - < 0.01 1.00E00 1.00E00 nuclear thyroid hormone receptor binding (GO:0046966) 28 0 .01 - < 0.01 1.00E00 1.00E00 nuclear retinoid X receptor binding (GO:0046965) 17 0 .00 - < 0.01 1.00E00 1.00E00 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity (GO:0046964) 2 0 .00 - < 0.01 1.00E00 1.00E00 3',5'-nucleotide bisphosphate phosphatase activity (GO:0097657) 1 0 .00 - < 0.01 1.00E00 1.00E00 pseudophosphatase activity (GO:0001691) 2 0 .00 - < 0.01 1.00E00 1.00E00 serpin family protein binding (GO:0097655) 1 0 .00 - < 0.01 1.00E00 1.00E00 proton-transporting ATPase activity, rotational mechanism (GO:0046961) 24 0 .01 - < 0.01 1.00E00 1.00E00 tRNA dimethylallyltransferase activity (GO:0052381) 1 0 .00 - < 0.01 1.00E00 1.00E00 chloride:proton antiporter activity (GO:0062158) 2 0 .00 - < 0.01 1.00E00 1.00E00 4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868) 2 0 .00 - < 0.01 1.00E00 1.00E00 mitochondrial ATP-gated potassium channel activity (GO:0062156) 1 0 .00 - < 0.01 1.00E00 1.00E00 N6-methyl-AMP deaminase activity (GO:0062154) 1 0 .00 - < 0.01 1.00E00 1.00E00 3-oxo-5-alpha-steroid 4-dehydrogenase activity (GO:0003865) 3 0 .00 - < 0.01 1.00E00 1.00E00 C5-methylcytidine-containing RNA reader activity (GO:0062153) 4 0 .00 - < 0.01 1.00E00 1.00E00 mRNA (cytidine-5-)-methyltransferase activity (GO:0062152) 2 0 .00 - < 0.01 1.00E00 1.00E00 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity (GO:0003863) 2 0 .00 - < 0.01 1.00E00 1.00E00 troponin T binding (GO:0031014) 4 0 .00 - < 0.01 1.00E00 1.00E00 troponin I binding (GO:0031013) 4 0 .00 - < 0.01 1.00E00 1.00E00 3-hydroxyisobutyryl-CoA hydrolase activity (GO:0003860) 1 0 .00 - < 0.01 1.00E00 1.00E00 sialate O-acetylesterase activity (GO:0001681) 1 0 .00 - < 0.01 1.00E00 1.00E00 amylin binding (GO:0097645) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcitonin family binding (GO:0097644) 5 0 .00 - < 0.01 1.00E00 1.00E00 amylin receptor activity (GO:0097643) 3 0 .00 - < 0.01 1.00E00 1.00E00 calcitonin family receptor activity (GO:0097642) 6 0 .00 - < 0.01 1.00E00 1.00E00 phytanate-CoA ligase activity (GO:0050197) 2 0 .00 - < 0.01 1.00E00 1.00E00 [phosphorylase] phosphatase activity (GO:0050196) 2 0 .00 - < 0.01 1.00E00 1.00E00 3-hydroxybutyrate dehydrogenase activity (GO:0003858) 2 0 .00 - < 0.01 1.00E00 1.00E00 3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857) 6 0 .00 - < 0.01 1.00E00 1.00E00 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity (GO:0003854) 4 0 .00 - < 0.01 1.00E00 1.00E00 short-chain 2-methyl fatty acyl-CoA dehydrogenase activity (GO:0003853) 2 0 .00 - < 0.01 1.00E00 1.00E00 filamin binding (GO:0031005) 14 0 .00 - < 0.01 1.00E00 1.00E00 N-acylsphingosine galactosyltransferase activity (GO:0003851) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATPase activator activity (GO:0001671) 27 0 .01 - < 0.01 1.00E00 1.00E00 carboxylic acid transmembrane transporter activity (GO:0046943) 189 0 .06 - < 0.01 1.00E00 1.00E00 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism (GO:0044769) 24 0 .01 - < 0.01 1.00E00 1.00E00 phosphoamidase activity (GO:0050187) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol deacylase activity (GO:0050185) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptide deformylase activity (GO:0042586) 1 0 .00 - < 0.01 1.00E00 1.00E00 Fc-gamma receptor I complex binding (GO:0034988) 3 0 .00 - < 0.01 1.00E00 1.00E00 immunoglobulin receptor binding (GO:0034987) 19 0 .01 - < 0.01 1.00E00 1.00E00 iron chaperone activity (GO:0034986) 3 0 .00 - < 0.01 1.00E00 1.00E00 1-alkyl-2-acetylglycerophosphocholine esterase activity (GO:0003847) 8 0 .00 - < 0.01 1.00E00 1.00E00 2-acylglycerol O-acyltransferase activity (GO:0003846) 7 0 .00 - < 0.01 1.00E00 1.00E00 11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity (GO:0003845) 2 0 .00 - < 0.01 1.00E00 1.00E00 1,4-alpha-glucan branching enzyme activity (GO:0003844) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-pyrroline-5-carboxylate dehydrogenase activity (GO:0003842) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-acylglycerol-3-phosphate O-acyltransferase activity (GO:0003841) 21 0 .01 - < 0.01 1.00E00 1.00E00 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity (GO:0001665) 6 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled receptor binding (GO:0001664) 297 0 .09 - < 0.01 1.00E00 1.00E00 2'-deoxyadenosine deaminase activity (GO:0046936) 3 0 .00 - < 0.01 1.00E00 1.00E00 1-phosphatidylinositol-3-kinase regulator activity (GO:0046935) 6 0 .00 - < 0.01 1.00E00 1.00E00 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934) 7 0 .00 - < 0.01 1.00E00 1.00E00 proton-transporting ATP synthase activity, rotational mechanism (GO:0046933) 18 0 .01 - < 0.01 1.00E00 1.00E00 phenylpyruvate tautomerase activity (GO:0050178) 3 0 .00 - < 0.01 1.00E00 1.00E00 monoamine oxidase activity (GO:0097621) 3 0 .00 - < 0.01 1.00E00 1.00E00 phosphoric ester hydrolase activity (GO:0042578) 362 0 .11 - < 0.01 1.00E00 1.00E00 lipid phosphatase activity (GO:0042577) 19 0 .01 - < 0.01 1.00E00 1.00E00 NAD-dependent protein lysine deacetylase activity (GO:0034979) 7 0 .00 - < 0.01 1.00E00 1.00E00 gamma-glutamylcyclotransferase activity (GO:0003839) 3 0 .00 - < 0.01 1.00E00 1.00E00 beta-ureidopropionase activity (GO:0003837) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity (GO:0003836) 7 0 .00 - < 0.01 1.00E00 1.00E00 beta-galactoside alpha-2,6-sialyltransferase activity (GO:0003835) 2 0 .00 - < 0.01 1.00E00 1.00E00 4-hydroxybutyrate receptor activity (GO:0062124) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-carotene 15,15'-dioxygenase activity (GO:0003834) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K37 methyltransferase activity (GO:0062122) 8 0 .00 - < 0.01 1.00E00 1.00E00 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity (GO:0003831) 4 0 .00 - < 0.01 1.00E00 1.00E00 heterotrimeric G-protein binding (GO:0032795) 6 0 .00 - < 0.01 1.00E00 1.00E00 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity (GO:0003830) 1 0 .00 - < 0.01 1.00E00 1.00E00 GTPase activating protein binding (GO:0032794) 11 0 .00 - < 0.01 1.00E00 1.00E00 lead ion binding (GO:0032791) 2 0 .00 - < 0.01 1.00E00 1.00E00 peptide receptor activity (GO:0001653) 130 0 .04 - < 0.01 1.00E00 1.00E00 ER retention sequence binding (GO:0046923) 5 0 .00 - < 0.01 1.00E00 1.00E00 peptide-O-fucosyltransferase activity (GO:0046922) 2 0 .00 - < 0.01 1.00E00 1.00E00 alpha-(1->6)-fucosyltransferase activity (GO:0046921) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-(1->3)-fucosyltransferase activity (GO:0046920) 8 0 .00 - < 0.01 1.00E00 1.00E00 oxaloacetate tautomerase activity (GO:0050163) 3 0 .00 - < 0.01 1.00E00 1.00E00 cuprous ion binding (GO:1903136) 9 0 .00 - < 0.01 1.00E00 1.00E00 cupric ion binding (GO:1903135) 5 0 .00 - < 0.01 1.00E00 1.00E00 hormone binding (GO:0042562) 95 0 .03 - < 0.01 1.00E00 1.00E00 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity (GO:0003829) 3 0 .00 - < 0.01 1.00E00 1.00E00 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity (GO:0003828) 6 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity (GO:0003827) 1 0 .00 - < 0.01 1.00E00 1.00E00 antigen binding (GO:0003823) 197 0 .06 - < 0.01 1.00E00 1.00E00 vascular endothelial growth factor binding (GO:0038085) 5 0 .00 - < 0.01 1.00E00 1.00E00 L-lysine:L-arginine antiporter activity (GO:0106439) 1 0 .00 - < 0.01 1.00E00 1.00E00 proteinase-activated receptor activity (GO:0001648) 5 0 .00 - < 0.01 1.00E00 1.00E00 protein-glutamic acid ligase activity, elongating (GO:0106438) 7 0 .00 - < 0.01 1.00E00 1.00E00 protein-glutamic acid ligase activity, initiating (GO:0106437) 5 0 .00 - < 0.01 1.00E00 1.00E00 glutathione-dependent sulfide quinone oxidoreductase activity (GO:0106436) 1 0 .00 - < 0.01 1.00E00 1.00E00 carboxylesterase activity (GO:0106435) 6 0 .00 - < 0.01 1.00E00 1.00E00 transition metal ion transmembrane transporter activity (GO:0046915) 44 0 .01 - < 0.01 1.00E00 1.00E00 O6-methyl-dGTP hydrolase activity (GO:0106433) 1 0 .00 - < 0.01 1.00E00 1.00E00 group III metabotropic glutamate receptor activity (GO:0001642) 2 0 .00 - < 0.01 1.00E00 1.00E00 transition metal ion binding (GO:0046914) 2429 1 .71 + 1.41 5.29E-01 1.00E00 group II metabotropic glutamate receptor activity (GO:0001641) 2 0 .00 - < 0.01 1.00E00 1.00E00 N6-methyl-(d)ATP hydrolase activity (GO:0106431) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity (GO:0001640) 9 0 .00 - < 0.01 1.00E00 1.00E00 acyltransferase activity, acyl groups converted into alkyl on transfer (GO:0046912) 5 0 .00 - < 0.01 1.00E00 1.00E00 dihydroorotate dehydrogenase (quinone) activity (GO:0106430) 1 0 .00 - < 0.01 1.00E00 1.00E00 metal chelating activity (GO:0046911) 1 0 .00 - < 0.01 1.00E00 1.00E00 temperature-gated cation channel activity (GO:0097604) 2 0 .00 - < 0.01 1.00E00 1.00E00 temperature-gated ion channel activity (GO:0097603) 3 0 .00 - < 0.01 1.00E00 1.00E00 cullin family protein binding (GO:0097602) 26 0 .01 - < 0.01 1.00E00 1.00E00 omega-hydroxydecanoate dehydrogenase activity (GO:0050153) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta,beta-carotene-9',10'-cleaving oxygenase activity (GO:0102076) 1 0 .00 - < 0.01 1.00E00 1.00E00 omega-amidase activity (GO:0050152) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA 2'-O-methyltransferase activity (GO:0062105) 9 0 .00 - < 0.01 1.00E00 1.00E00 pumilio-response element binding (GO:0062104) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-aspartic acid 3-dioxygenase activity (GO:0062101) 2 0 .00 - < 0.01 1.00E00 1.00E00 11-cis-retinol dehydrogenase (GO:0106429) 2 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled chemoattractant receptor activity (GO:0001637) 26 0 .01 - < 0.01 1.00E00 1.00E00 protein-glutamine gamma-glutamyltransferase activity (GO:0003810) 9 0 .00 - < 0.01 1.00E00 1.00E00 calcitonin gene-related peptide receptor activity (GO:0001635) 4 0 .00 - < 0.01 1.00E00 1.00E00 pituitary adenylate cyclase-activating polypeptide receptor activity (GO:0001634) 3 0 .00 - < 0.01 1.00E00 1.00E00 tetrapyrrole binding (GO:0046906) 152 1 .04 + 22.57 4.35E-02 1.00E00 tubulin-tyrosine carboxypeptidase (GO:0106423) 3 0 .00 - < 0.01 1.00E00 1.00E00 leukotriene B4 receptor activity (GO:0001632) 2 0 .00 - < 0.01 1.00E00 1.00E00 calcium oxalate binding (GO:0046904) 2 0 .00 - < 0.01 1.00E00 1.00E00 cysteinyl leukotriene receptor activity (GO:0001631) 2 0 .00 - < 0.01 1.00E00 1.00E00 neurotransmitter receptor activity (GO:0030594) 97 0 .03 - < 0.01 1.00E00 1.00E00 hemi-methylated DNA-binding (GO:0044729) 3 0 .00 - < 0.01 1.00E00 1.00E00 NAD-dependent protein biotinidase activity (GO:0106420) 1 0 .00 - < 0.01 1.00E00 1.00E00 nucleoside phosphotransferase activity (GO:0050146) 1 0 .00 - < 0.01 1.00E00 1.00E00 nucleoside monophosphate kinase activity (GO:0050145) 20 0 .01 - < 0.01 1.00E00 1.00E00 copper-dependent protein binding (GO:0032767) 3 0 .00 - < 0.01 1.00E00 1.00E00 NAD-dependent protein lipoamidase activity (GO:0106419) 1 0 .00 - < 0.01 1.00E00 1.00E00 collagen receptor activity (GO:0038064) 53 0 .02 - < 0.01 1.00E00 1.00E00 nociceptin receptor activity (GO:0001626) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein tyrosine kinase collagen receptor activity (GO:0038062) 49 0 .01 - < 0.01 1.00E00 1.00E00 mRNA dihydrouridine synthase activity (GO:0106414) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA dihydrouridine synthase activity (GO:0106413) 4 0 .00 - < 0.01 1.00E00 1.00E00 [methionine synthase] reductase (NADPH) activity (GO:0030586) 1 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled ADP receptor activity (GO:0001621) 3 0 .00 - < 0.01 1.00E00 1.00E00 XMP 5'-nucleosidase activity (GO:0106411) 6 0 .00 - < 0.01 1.00E00 1.00E00 8-hydroxy-dADP phosphatase activity (GO:0044717) 1 0 .00 - < 0.01 1.00E00 1.00E00 8-oxo-GDP phosphatase activity (GO:0044716) 2 0 .00 - < 0.01 1.00E00 1.00E00 8-oxo-dGDP phosphatase activity (GO:0044715) 3 0 .00 - < 0.01 1.00E00 1.00E00 NADPH peroxidase activity (GO:0050137) 1 0 .00 - < 0.01 1.00E00 1.00E00 NADH:ubiquinone reductase (non-electrogenic) activity (GO:0050136) 1 0 .00 - < 0.01 1.00E00 1.00E00 NADP+ nucleosidase activity (GO:0050135) 1 0 .00 - < 0.01 1.00E00 1.00E00 virus receptor activity (GO:0001618) 81 0 .02 - < 0.01 1.00E00 1.00E00 G protein-coupled estrogen receptor activity (GO:0038054) 2 0 .00 - < 0.01 1.00E00 1.00E00 Glc2Man9GlcNAc2 oligosaccharide glucosidase activity (GO:0106407) 1 0 .00 - < 0.01 1.00E00 1.00E00 growth hormone secretagogue receptor activity (GO:0001616) 1 0 .00 - < 0.01 1.00E00 1.00E00 isoprenoid diphosphate phosphatase activity (GO:0106405) 1 0 .00 - < 0.01 1.00E00 1.00E00 purinergic nucleotide receptor activity (GO:0001614) 20 0 .01 - < 0.01 1.00E00 1.00E00 phosphatidyltransferase activity (GO:0030572) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acylneuraminate-9-phosphatase activity (GO:0050124) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acylglucosamine 2-epimerase activity (GO:0050121) 1 0 .00 - < 0.01 1.00E00 1.00E00 dynorphin receptor activity (GO:0038048) 1 0 .00 - < 0.01 1.00E00 1.00E00 morphine receptor activity (GO:0038047) 1 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled enkephalin receptor activity (GO:0038046) 1 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled adenosine receptor activity (GO:0001609) 5 0 .00 - < 0.01 1.00E00 1.00E00 neuromedin U receptor activity (GO:0001607) 2 0 .00 - < 0.01 1.00E00 1.00E00 adrenomedullin receptor activity (GO:0001605) 3 0 .00 - < 0.01 1.00E00 1.00E00 urotensin II receptor activity (GO:0001604) 2 0 .00 - < 0.01 1.00E00 1.00E00 pancreatic polypeptide receptor activity (GO:0001602) 4 0 .00 - < 0.01 1.00E00 1.00E00 peptide YY receptor activity (GO:0001601) 3 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylglucosamine deacetylase activity (GO:0050119) 3 0 .00 - < 0.01 1.00E00 1.00E00 NADH-dependent peroxiredoxin activity (GO:0102039) 1 0 .00 - < 0.01 1.00E00 1.00E00 myosin-light-chain-phosphatase activity (GO:0050115) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol oxygenase activity (GO:0050113) 1 0 .00 - < 0.01 1.00E00 1.00E00 long-chain fatty acid omega-hydroxylase activity (GO:0102033) 8 0 .00 - < 0.01 1.00E00 1.00E00 sphingosine-1-phosphate receptor activity (GO:0038036) 9 0 .00 - < 0.01 1.00E00 1.00E00 protein-glutaryllysine deglutarylase activity (GO:0061697) 2 0 .00 - < 0.01 1.00E00 1.00E00 adenyl nucleotide binding (GO:0030554) 1618 1 .47 + 2.12 3.88E-01 1.00E00 cGMP binding (GO:0030553) 15 0 .00 - < 0.01 1.00E00 1.00E00 lipoamidase activity (GO:0061690) 1 0 .00 - < 0.01 1.00E00 1.00E00 cAMP binding (GO:0030552) 24 0 .01 - < 0.01 1.00E00 1.00E00 cyclic nucleotide binding (GO:0030551) 37 0 .01 - < 0.01 1.00E00 1.00E00 acetylcholine receptor inhibitor activity (GO:0030550) 8 0 .00 - < 0.01 1.00E00 1.00E00 L-gulonate 3-dehydrogenase activity (GO:0050104) 1 0 .00 - < 0.01 1.00E00 1.00E00 benzaldehyde dehydrogenase (NAD+) activity (GO:0018479) 4 0 .00 - < 0.01 1.00E00 1.00E00 malonate-semialdehyde dehydrogenase (acetylating) activity (GO:0018478) 1 0 .00 - < 0.01 1.00E00 1.00E00 benzaldehyde dehydrogenase (NADP+) activity (GO:0018477) 1 0 .00 - < 0.01 1.00E00 1.00E00 aspartic endopeptidase activity, intramembrane cleaving (GO:0042500) 8 0 .00 - < 0.01 1.00E00 1.00E00 lipase activity (GO:0016298) 131 0 .04 - < 0.01 1.00E00 1.00E00 fatty acyl-[ACP] hydrolase activity (GO:0016297) 2 0 .00 - < 0.01 1.00E00 1.00E00 anaphase-promoting complex binding (GO:0010997) 9 0 .00 - < 0.01 1.00E00 1.00E00 reelin receptor activity (GO:0038025) 2 0 .00 - < 0.01 1.00E00 1.00E00 cargo receptor activity (GO:0038024) 65 0 .02 - < 0.01 1.00E00 1.00E00 signaling receptor activity (GO:0038023) 1563 0 .46 - < 0.01 1.00E00 1.00E00 G protein-coupled olfactory receptor activity (GO:0038022) 2 0 .00 - < 0.01 1.00E00 1.00E00 acetylcholine receptor activator activity (GO:0030549) 4 0 .00 - < 0.01 1.00E00 1.00E00 leptin receptor activity (GO:0038021) 1 0 .00 - < 0.01 1.00E00 1.00E00 acetylcholine receptor regulator activity (GO:0030548) 18 0 .01 - < 0.01 1.00E00 1.00E00 diphthine methylesterase activity (GO:0061685) 1 0 .00 - < 0.01 1.00E00 1.00E00 signaling receptor inhibitor activity (GO:0030547) 45 0 .01 - < 0.01 1.00E00 1.00E00 signaling receptor activator activity (GO:0030546) 554 0 .16 - < 0.01 1.00E00 1.00E00 signaling receptor regulator activity (GO:0030545) 605 0 .18 - < 0.01 1.00E00 1.00E00 Hsp70 protein binding (GO:0030544) 51 0 .01 - < 0.01 1.00E00 1.00E00 formaldehyde dehydrogenase (NAD+) activity (GO:0018467) 2 0 .00 - < 0.01 1.00E00 1.00E00 acyl-CoA hydrolase activity (GO:0016289) 26 0 .01 - < 0.01 1.00E00 1.00E00 glycerone-phosphate O-acyltransferase activity (GO:0016287) 1 0 .00 - < 0.01 1.00E00 1.00E00 small conductance calcium-activated potassium channel activity (GO:0016286) 4 0 .00 - < 0.01 1.00E00 1.00E00 alanyl aminopeptidase activity (GO:0016285) 2 0 .00 - < 0.01 1.00E00 1.00E00 importin-alpha family protein binding (GO:0061676) 8 0 .00 - < 0.01 1.00E00 1.00E00 3-demethoxyubiquinol 3-hydroxylase activity (GO:0008682) 1 0 .00 - < 0.01 1.00E00 1.00E00 proline dipeptidase activity (GO:0102009) 1 0 .00 - < 0.01 1.00E00 1.00E00 acyl-L-homoserine-lactone lactonohydrolase activity (GO:0102007) 3 0 .00 - < 0.01 1.00E00 1.00E00 alcohol dehydrogenase [NAD(P)+] activity (GO:0018455) 52 1 .02 + 65.96 1.51E-02 1.00E00 protein-lysine N-methyltransferase activity (GO:0016279) 69 0 .02 - < 0.01 1.00E00 1.00E00 lysine N-methyltransferase activity (GO:0016278) 70 0 .02 - < 0.01 1.00E00 1.00E00 protein-arginine N-methyltransferase activity (GO:0016274) 12 0 .00 - < 0.01 1.00E00 1.00E00 arginine N-methyltransferase activity (GO:0016273) 12 0 .00 - < 0.01 1.00E00 1.00E00 UFM1 ligase activity (GO:0061666) 1 0 .00 - < 0.01 1.00E00 1.00E00 SUMO ligase activity (GO:0061665) 14 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of chromatin (GO:0030527) 65 0 .02 - < 0.01 1.00E00 1.00E00 NEDD8 ligase activity (GO:0061663) 4 0 .00 - < 0.01 1.00E00 1.00E00 2,4-dienoyl-CoA reductase (NADPH) activity (GO:0008670) 2 0 .00 - < 0.01 1.00E00 1.00E00 proteasome regulatory particle binding (GO:1904855) 2 0 .00 - < 0.01 1.00E00 1.00E00 G-quadruplex DNA binding (GO:0051880) 10 0 .00 - < 0.01 1.00E00 1.00E00 proteasome core complex binding (GO:1904854) 1 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-like protein ligase activity (GO:0061659) 372 0 .11 - < 0.01 1.00E00 1.00E00 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity (GO:0016263) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein N-acetylglucosaminyltransferase activity (GO:0016262) 1 0 .00 - < 0.01 1.00E00 1.00E00 UFM1 conjugating enzyme activity (GO:0061657) 1 0 .00 - < 0.01 1.00E00 1.00E00 snoRNP binding (GO:0030519) 1 0 .00 - < 0.01 1.00E00 1.00E00 SUMO conjugating enzyme activity (GO:0061656) 1 0 .00 - < 0.01 1.00E00 1.00E00 NEDD8 conjugating enzyme activity (GO:0061654) 2 0 .00 - < 0.01 1.00E00 1.00E00 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity (GO:0008663) 1 0 .00 - < 0.01 1.00E00 1.00E00 snoRNA binding (GO:0030515) 32 0 .01 - < 0.01 1.00E00 1.00E00 Atg12 conjugating enzyme activity (GO:0061651) 1 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-like protein conjugating enzyme activity (GO:0061650) 41 0 .01 - < 0.01 1.00E00 1.00E00 Hsp90 protein binding (GO:0051879) 42 0 .01 - < 0.01 1.00E00 1.00E00 rRNA (cytosine-N4-)-methyltransferase activity (GO:0071424) 2 0 .00 - < 0.01 1.00E00 1.00E00 TORC2 complex binding (GO:1904841) 5 0 .00 - < 0.01 1.00E00 1.00E00 glycerophosphoinositol glycerophosphodiesterase activity (GO:0047395) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycerophosphoinositol inositolphosphodiesterase activity (GO:0047394) 1 0 .00 - < 0.01 1.00E00 1.00E00 alkylglycerophosphoethanolamine phosphodiesterase activity (GO:0047391) 1 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-modified histone reader activity (GO:0061649) 9 0 .00 - < 0.01 1.00E00 1.00E00 glycerophosphocholine cholinephosphodiesterase activity (GO:0047390) 1 0 .00 - < 0.01 1.00E00 1.00E00 cysteine-type endopeptidase activator activity involved in apoptotic process (GO:0008656) 13 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II general transcription initiation factor activity (GO:0016251) 55 0 .02 - < 0.01 1.00E00 1.00E00 N-sulfoglucosamine sulfohydrolase activity (GO:0016250) 1 0 .00 - < 0.01 1.00E00 1.00E00 spectrin binding (GO:0030507) 26 0 .01 - < 0.01 1.00E00 1.00E00 ankyrin binding (GO:0030506) 19 0 .01 - < 0.01 1.00E00 1.00E00 inorganic diphosphate transmembrane transporter activity (GO:0030504) 1 0 .00 - < 0.01 1.00E00 1.00E00 rRNA (uridine-2'-O-)-methyltransferase activity (GO:0008650) 2 0 .00 - < 0.01 1.00E00 1.00E00 threonine-type endopeptidase activity (GO:0004298) 9 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K36 demethylase activity (GO:0051864) 10 0 .00 - < 0.01 1.00E00 1.00E00 glycolipid binding (GO:0051861) 29 0 .01 - < 0.01 1.00E00 1.00E00 glycerophosphocholine phosphodiesterase activity (GO:0047389) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein C-terminal leucine carboxyl O-methyltransferase activity (GO:0018423) 1 0 .00 - < 0.01 1.00E00 1.00E00 channel inhibitor activity (GO:0016248) 44 0 .01 - < 0.01 1.00E00 1.00E00 [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity (GO:0047385) 1 0 .00 - < 0.01 1.00E00 1.00E00 channel regulator activity (GO:0016247) 167 0 .05 - < 0.01 1.00E00 1.00E00 rRNA methyltransferase activity (GO:0008649) 22 0 .01 - < 0.01 1.00E00 1.00E00 coenzyme A diphosphatase activity (GO:0010945) 5 0 .00 - < 0.01 1.00E00 1.00E00 NADPH pyrophosphatase activity (GO:0010943) 2 0 .00 - < 0.01 1.00E00 1.00E00 alpha-glucosidase activity (GO:0090599) 8 0 .00 - < 0.01 1.00E00 1.00E00 RNA lariat debranching enzyme activator activity (GO:0061632) 1 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-like modifier activating enzyme activity (GO:0008641) 10 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin conjugating enzyme activity (GO:0061631) 35 0 .01 - < 0.01 1.00E00 1.00E00 ubiquitin protein ligase activity (GO:0061630) 353 0 .10 - < 0.01 1.00E00 1.00E00 acetylalkylglycerol acetylhydrolase activity (GO:0047378) 1 0 .00 - < 0.01 1.00E00 1.00E00 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity (GO:0047376) 3 0 .00 - < 0.01 1.00E00 1.00E00 methylumbelliferyl-acetate deacetylase activity (GO:0047374) 3 0 .00 - < 0.01 1.00E00 1.00E00 monoacylglycerol lipase activity (GO:0047372) 15 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629) 350 0 .10 - < 0.01 1.00E00 1.00E00 histone H3K27me3 reader activity (GO:0061628) 4 0 .00 - < 0.01 1.00E00 1.00E00 HNK-1 sulfotransferase activity (GO:0016232) 1 0 .00 - < 0.01 1.00E00 1.00E00 S-methylmethionine-homocysteine S-methyltransferase activity (GO:0061627) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-N-acetylglucosaminidase activity (GO:0016231) 4 0 .00 - < 0.01 1.00E00 1.00E00 sphingomyelin phosphodiesterase activator activity (GO:0016230) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands (GO:0090580) 1 0 .00 - < 0.01 1.00E00 1.00E00 succinate-hydroxymethylglutarate CoA-transferase activity (GO:0047369) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-alanine:pyruvate transaminase activity (GO:0016223) 1 0 .00 - < 0.01 1.00E00 1.00E00 translation factor activity, non-nucleic acid binding (GO:0045183) 2 0 .00 - < 0.01 1.00E00 1.00E00 translation regulator activity (GO:0045182) 58 0 .02 - < 0.01 1.00E00 1.00E00 1-alkenyl-2-acylglycerol choline phosphotransferase activity (GO:0047359) 1 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated potassium channel activity involved in SA node cell action potential repolarization (GO:0086090) 1 0 .00 - < 0.01 1.00E00 1.00E00 acyl-CoA desaturase activity (GO:0016215) 4 0 .00 - < 0.01 1.00E00 1.00E00 adenylylsulfate-ammonia adenylyltransferase activity (GO:0047352) 1 0 .00 - < 0.01 1.00E00 1.00E00 fructose-1-phosphate aldolase activity (GO:0061609) 1 0 .00 - < 0.01 1.00E00 1.00E00 linoleoyl-CoA desaturase activity (GO:0016213) 2 0 .00 - < 0.01 1.00E00 1.00E00 nuclear import signal receptor activity (GO:0061608) 20 0 .01 - < 0.01 1.00E00 1.00E00 kynurenine-oxoglutarate transaminase activity (GO:0016212) 4 0 .00 - < 0.01 1.00E00 1.00E00 ammonia ligase activity (GO:0016211) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutathione dehydrogenase (ascorbate) activity (GO:0045174) 2 0 .00 - < 0.01 1.00E00 1.00E00 molybdopterin-synthase adenylyltransferase activity (GO:0061605) 1 0 .00 - < 0.01 1.00E00 1.00E00 molybdopterin-synthase sulfurtransferase activity (GO:0061604) 1 0 .00 - < 0.01 1.00E00 1.00E00 diuretic hormone activity (GO:0008613) 1 0 .00 - < 0.01 1.00E00 1.00E00 2-(3-amino-3-carboxypropyl)histidine synthase activity (GO:0090560) 2 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization (GO:0086089) 4 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization (GO:0086087) 1 0 .00 - < 0.01 1.00E00 1.00E00 serine-type endopeptidase activity (GO:0004252) 178 0 .05 - < 0.01 1.00E00 1.00E00 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication (GO:0086083) 5 0 .00 - < 0.01 1.00E00 1.00E00 cell adhesive protein binding involved in AV node cell-bundle of His cell communication (GO:0086082) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-ribitol-5-phosphate cytidylyltransferase activity (GO:0047349) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein binding involved in heterotypic cell-cell adhesion (GO:0086080) 12 0 .00 - < 0.01 1.00E00 1.00E00 antioxidant activity (GO:0016209) 85 0 .02 - < 0.01 1.00E00 1.00E00 AMP binding (GO:0016208) 12 0 .00 - < 0.01 1.00E00 1.00E00 catechol O-methyltransferase activity (GO:0016206) 2 0 .00 - < 0.01 1.00E00 1.00E00 alkylglycerone-phosphate synthase activity (GO:0008609) 1 0 .00 - < 0.01 1.00E00 1.00E00 fucose-1-phosphate guanylyltransferase activity (GO:0047341) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphorylase kinase regulator activity (GO:0008607) 3 0 .00 - < 0.01 1.00E00 1.00E00 cAMP-dependent protein kinase regulator activity (GO:0008603) 12 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylserine floppase activity (GO:0090556) 9 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylethanolamine flippase activity (GO:0090555) 6 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylcholine floppase activity (GO:0090554) 8 0 .00 - < 0.01 1.00E00 1.00E00 molecular sensor activity (GO:0140299) 74 0 .02 - < 0.01 1.00E00 1.00E00 gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling (GO:0086079) 1 0 .00 - < 0.01 1.00E00 1.00E00 gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling (GO:0086078) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-binding transcription factor binding (GO:0140297) 489 0 .14 - < 0.01 1.00E00 1.00E00 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling (GO:0086077) 3 0 .00 - < 0.01 1.00E00 1.00E00 general transcription initiation factor binding (GO:0140296) 54 0 .02 - < 0.01 1.00E00 1.00E00 gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling (GO:0086076) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATP-gated ion channel activity (GO:0035381) 9 0 .00 - < 0.01 1.00E00 1.00E00 gap junction channel activity involved in cardiac conduction electrical coupling (GO:0086075) 4 0 .00 - < 0.01 1.00E00 1.00E00 NAD DNA ADP-ribosyltransferase activity (GO:0140294) 3 0 .00 - < 0.01 1.00E00 1.00E00 ADP-ribosylglutamate hydrolase activity (GO:0140293) 3 0 .00 - < 0.01 1.00E00 1.00E00 ADP-ribosylserine hydrolase activity (GO:0140292) 1 0 .00 - < 0.01 1.00E00 1.00E00 pyrimidine nucleobase binding (GO:0002061) 1 0 .00 - < 0.01 1.00E00 1.00E00 purine nucleobase binding (GO:0002060) 3 0 .00 - < 0.01 1.00E00 1.00E00 myosin II binding (GO:0045159) 13 0 .00 - < 0.01 1.00E00 1.00E00 type 1 melanocortin receptor binding (GO:0070996) 4 0 .00 - < 0.01 1.00E00 1.00E00 medium-chain fatty acyl-CoA dehydrogenase activity (GO:0070991) 3 0 .00 - < 0.01 1.00E00 1.00E00 snRNP binding (GO:0070990) 11 0 .00 - < 0.01 1.00E00 1.00E00 carbon dioxide transmembrane transporter activity (GO:0035379) 5 0 .00 - < 0.01 1.00E00 1.00E00 MIT domain binding (GO:0090541) 3 0 .00 - < 0.01 1.00E00 1.00E00 initiator methionyl aminopeptidase activity (GO:0004239) 5 0 .00 - < 0.01 1.00E00 1.00E00 zymogen binding (GO:0035375) 1 0 .00 - < 0.01 1.00E00 1.00E00 chondroitin sulfate binding (GO:0035374) 10 0 .00 - < 0.01 1.00E00 1.00E00 chondroitin sulfate proteoglycan binding (GO:0035373) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity (GO:0051800) 2 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated sodium channel activity involved in SA node cell action potential (GO:0086063) 1 0 .00 - < 0.01 1.00E00 1.00E00 uracil binding (GO:0002058) 1 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated sodium channel activity involved in Purkinje myocyte action potential (GO:0086062) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutamyl aminopeptidase activity (GO:0004230) 1 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated sodium channel activity involved in bundle of His cell action potential (GO:0086061) 1 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated sodium channel activity involved in AV node cell action potential (GO:0086060) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenine binding (GO:0002055) 1 0 .00 - < 0.01 1.00E00 1.00E00 calmodulin-dependent protein phosphatase activity (GO:0033192) 80 0 .02 - < 0.01 1.00E00 1.00E00 nucleobase binding (GO:0002054) 4 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,3,4,6-tetrakisphosphate 5-kinase activity (GO:0047326) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity (GO:0047325) 1 0 .00 - < 0.01 1.00E00 1.00E00 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity (GO:0047323) 1 0 .00 - < 0.01 1.00E00 1.00E00 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity (GO:0047322) 2 0 .00 - < 0.01 1.00E00 1.00E00 tripeptide aminopeptidase activity (GO:0045148) 1 0 .00 - < 0.01 1.00E00 1.00E00 single-stranded DNA 5'-3' DNA exonuclease activity (GO:0045145) 5 0 .00 - < 0.01 1.00E00 1.00E00 triplex DNA binding (GO:0045142) 2 0 .00 - < 0.01 1.00E00 1.00E00 selenocysteine insertion sequence binding (GO:0035368) 4 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated calcium channel activity involved SA node cell action potential (GO:0086059) 2 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated calcium channel activity involved in bundle of His cell action potential (GO:0086057) 1 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated calcium channel activity involved in AV node cell action potential (GO:0086056) 3 0 .00 - < 0.01 1.00E00 1.00E00 sphingomyelin synthase activity (GO:0033188) 3 0 .00 - < 0.01 1.00E00 1.00E00 metalloendopeptidase activity (GO:0004222) 110 0 .03 - < 0.01 1.00E00 1.00E00 exogenous protein binding (GO:0140272) 82 0 .02 - < 0.01 1.00E00 1.00E00 opsin binding (GO:0002046) 5 0 .00 - < 0.01 1.00E00 1.00E00 glutamine-phenylpyruvate transaminase activity (GO:0047316) 1 0 .00 - < 0.01 1.00E00 1.00E00 kynurenine-glyoxylate transaminase activity (GO:0047315) 2 0 .00 - < 0.01 1.00E00 1.00E00 TIR domain binding (GO:0070976) 1 0 .00 - < 0.01 1.00E00 1.00E00 FHA domain binding (GO:0070975) 1 0 .00 - < 0.01 1.00E00 1.00E00 POU domain binding (GO:0070974) 5 0 .00 - < 0.01 1.00E00 1.00E00 UDP phosphatase activity (GO:0045134) 9 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential (GO:0150047) 3 0 .00 - < 0.01 1.00E00 1.00E00 keratan sulfotransferase activity (GO:0045130) 2 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of synapse-associated extracellular matrix (GO:0150043) 2 0 .00 - < 0.01 1.00E00 1.00E00 p53 binding (GO:0002039) 69 0 .02 - < 0.01 1.00E00 1.00E00 mRNA cap binding complex binding (GO:0140262) 4 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated potassium channel activity involved in SA node cell action potential depolarization (GO:0086041) 1 0 .00 - < 0.01 1.00E00 1.00E00 mitochondrial proton-transporting ATP synthase complex binding (GO:0140260) 2 0 .00 - < 0.01 1.00E00 1.00E00 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity (GO:0047305) 1 0 .00 - < 0.01 1.00E00 1.00E00 co-receptor binding (GO:0039706) 13 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylglucosamine kinase activity (GO:0045127) 1 0 .00 - < 0.01 1.00E00 1.00E00 bioactive lipid receptor activity (GO:0045125) 17 0 .00 - < 0.01 1.00E00 1.00E00 P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential (GO:0086039) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential (GO:0086038) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycolipid 1,6-alpha-mannosyltransferase activity (GO:0033164) 1 0 .00 - < 0.01 1.00E00 1.00E00 protease binding (GO:0002020) 137 0 .04 - < 0.01 1.00E00 1.00E00 azole:proton antiporter activity (GO:0045119) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidised low-density lipoprotein particle receptor activity (GO:0150025) 1 0 .00 - < 0.01 1.00E00 1.00E00 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling (GO:0086020) 2 0 .00 - < 0.01 1.00E00 1.00E00 Toll-like receptor binding (GO:0035325) 13 0 .00 - < 0.01 1.00E00 1.00E00 FFAT motif binding (GO:0033149) 3 0 .00 - < 0.01 1.00E00 1.00E00 intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential (GO:0140232) 1 0 .00 - < 0.01 1.00E00 1.00E00 nuclear progesterone receptor binding (GO:0033142) 2 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008) 14 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated calcium channel activity involved in cardiac muscle cell action potential (GO:0086007) 5 0 .00 - < 0.01 1.00E00 1.00E00 RNA topoisomerase activity (GO:0140226) 1 0 .00 - < 0.01 1.00E00 1.00E00 5'-3' DNA exonuclease activity (GO:0035312) 9 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006) 4 0 .00 - < 0.01 1.00E00 1.00E00 general transcription initiation factor activity (GO:0140223) 70 0 .02 - < 0.01 1.00E00 1.00E00 acetylcholine receptor binding (GO:0033130) 16 0 .00 - < 0.01 1.00E00 1.00E00 nucleoside triphosphate adenylate kinase activity (GO:0046899) 3 0 .00 - < 0.01 1.00E00 1.00E00 folic acid:proton symporter activity (GO:0140211) 1 0 .00 - < 0.01 1.00E00 1.00E00 lysozyme activity (GO:0003796) 9 0 .00 - < 0.01 1.00E00 1.00E00 HLA-E specific inhibitory MHC class Ib receptor activity (GO:0062082) 2 0 .00 - < 0.01 1.00E00 1.00E00 activating MHC class Ib receptor activity (GO:0062081) 1 0 .00 - < 0.01 1.00E00 1.00E00 inhibitory MHC class Ib receptor activity (GO:0062080) 2 0 .00 - < 0.01 1.00E00 1.00E00 lysophosphatidic acid receptor activity (GO:0070915) 5 0 .00 - < 0.01 1.00E00 1.00E00 TSC1-TSC2 complex binding (GO:0062078) 2 0 .00 - < 0.01 1.00E00 1.00E00 acyl-CoA delta5-desaturase activity (GO:0062076) 1 0 .00 - < 0.01 1.00E00 1.00E00 actin monomer binding (GO:0003785) 30 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K9me3 reader activity (GO:0062072) 4 0 .00 - < 0.01 1.00E00 1.00E00 serine binding (GO:0070905) 4 0 .00 - < 0.01 1.00E00 1.00E00 ephrin receptor binding (GO:0046875) 28 0 .01 - < 0.01 1.00E00 1.00E00 metal ion transmembrane transporter activity (GO:0046873) 449 0 .13 - < 0.01 1.00E00 1.00E00 metal ion binding (GO:0046872) 4369 1 1.27 - .79 1.00E00 1.00E00 cadmium ion binding (GO:0046870) 5 0 .00 - < 0.01 1.00E00 1.00E00 GARP complex binding (GO:0062069) 1 0 .00 - < 0.01 1.00E00 1.00E00 actin binding (GO:0003779) 447 0 .13 - < 0.01 1.00E00 1.00E00 microtubule motor activity (GO:0003777) 68 0 .02 - < 0.01 1.00E00 1.00E00 box C/D methylation guide snoRNP complex binding (GO:0062064) 1 0 .00 - < 0.01 1.00E00 1.00E00 cytoskeletal motor activity (GO:0003774) 114 0 .03 - < 0.01 1.00E00 1.00E00 BBSome binding (GO:0062063) 2 0 .00 - < 0.01 1.00E00 1.00E00 oligosaccharyltransferase complex binding (GO:0062062) 1 0 .00 - < 0.01 1.00E00 1.00E00 TAP complex binding (GO:0062061) 3 0 .00 - < 0.01 1.00E00 1.00E00 NuA4 histone acetyltransferase complex binding (GO:0062060) 1 0 .00 - < 0.01 1.00E00 1.00E00 18S rRNA aminocarboxypropyltransferase activity (GO:0106388) 1 0 .00 - < 0.01 1.00E00 1.00E00 angiotensin type I receptor activity (GO:0001596) 1 0 .00 - < 0.01 1.00E00 1.00E00 (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity (GO:0106386) 2 0 .00 - < 0.01 1.00E00 1.00E00 angiotensin receptor activity (GO:0001595) 4 0 .00 - < 0.01 1.00E00 1.00E00 trace-amine receptor activity (GO:0001594) 8 0 .00 - < 0.01 1.00E00 1.00E00 dopamine neurotransmitter receptor activity, coupled via Gi/Go (GO:0001591) 3 0 .00 - < 0.01 1.00E00 1.00E00 fluoride channel activity (GO:0062054) 1 0 .00 - < 0.01 1.00E00 1.00E00 8-oxo-(d)RTP hydrolase activity (GO:0106379) 5 0 .00 - < 0.01 1.00E00 1.00E00 dopamine neurotransmitter receptor activity, coupled via Gs (GO:0001588) 2 0 .00 - < 0.01 1.00E00 1.00E00 GPI-mannose ethanolamine phosphate phosphodiesterase activity (GO:0062050) 1 0 .00 - < 0.01 1.00E00 1.00E00 2-hydroxy-dATP hydrolase activity (GO:0106378) 1 0 .00 - < 0.01 1.00E00 1.00E00 Gq/11-coupled serotonin receptor activity (GO:0001587) 3 0 .00 - < 0.01 1.00E00 1.00E00 2-hydroxy-ATP hydrolase activity (GO:0106377) 1 0 .00 - < 0.01 1.00E00 1.00E00 Gi/o-coupled serotonin receptor activity (GO:0001586) 6 0 .00 - < 0.01 1.00E00 1.00E00 2-hydroxyphytanoyl-CoA lyase activity (GO:0106376) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor (GO:0046857) 2 0 .00 - < 0.01 1.00E00 1.00E00 deoxynucleoside triphosphate hydrolase activity (GO:0106375) 1 0 .00 - < 0.01 1.00E00 1.00E00 3-deoxyglucosone dehydrogenase activity (GO:0106373) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-L-histidine N-pros-methyltransferase activity (GO:0106370) 1 0 .00 - < 0.01 1.00E00 1.00E00 methionine-glyoxylate transaminase activity (GO:0050094) 1 0 .00 - < 0.01 1.00E00 1.00E00 triacyl lipopeptide binding (GO:0042497) 1 0 .00 - < 0.01 1.00E00 1.00E00 trimethylamine monooxygenase activity (GO:0034899) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein disulfide isomerase activity (GO:0003756) 18 0 .01 - < 0.01 1.00E00 1.00E00 electron transfer activity (GO:0009055) 114 1 .03 + 30.09 3.28E-02 1.00E00 peptidyl-prolyl cis-trans isomerase activity (GO:0003755) 40 0 .01 - < 0.01 1.00E00 1.00E00 hydroxyapatite binding (GO:0046848) 5 0 .00 - < 0.01 1.00E00 1.00E00 4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity (GO:0106364) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-cysteine methyltransferase activity (GO:0106363) 2 0 .00 - < 0.01 1.00E00 1.00E00 malonyl-CoA decarboxylase activity (GO:0050080) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-loop DNA binding (GO:0062037) 5 0 .00 - < 0.01 1.00E00 1.00E00 translation release factor activity (GO:0003747) 7 0 .00 - < 0.01 1.00E00 1.00E00 translation elongation factor activity (GO:0003746) 19 0 .01 - < 0.01 1.00E00 1.00E00 translation initiation factor activity (GO:0003743) 51 0 .01 - < 0.01 1.00E00 1.00E00 UMP/dUMP kinase activity (GO:0009041) 3 0 .00 - < 0.01 1.00E00 1.00E00 2-hydroxyacyl-CoA lyase activity (GO:0106359) 1 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol 25-hydroxylase activity (GO:0001567) 1 0 .00 - < 0.01 1.00E00 1.00E00 caffeine oxidase activity (GO:0034875) 4 0 .00 - < 0.01 1.00E00 1.00E00 type II site-specific deoxyribonuclease activity (GO:0009036) 1 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of ribosome (GO:0003735) 164 0 .05 - < 0.01 1.00E00 1.00E00 thymidine phosphorylase activity (GO:0009032) 2 0 .00 - < 0.01 1.00E00 1.00E00 mRNA 3'-UTR binding (GO:0003730) 112 0 .03 - < 0.01 1.00E00 1.00E00 U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity (GO:0106347) 1 0 .00 - < 0.01 1.00E00 1.00E00 snRNA methyltransferase activity (GO:0106346) 3 0 .00 - < 0.01 1.00E00 1.00E00 glyoxylate reductase activity (GO:0106345) 1 0 .00 - < 0.01 1.00E00 1.00E00 omega-hydroxyceramide transacylase activity (GO:0106341) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity (GO:0106340) 1 0 .00 - < 0.01 1.00E00 1.00E00 long-chain fatty aldehyde dehydrogenase (NAD+) activity (GO:0050061) 3 0 .00 - < 0.01 1.00E00 1.00E00 mRNA binding (GO:0003729) 346 0 .10 - < 0.01 1.00E00 1.00E00 single-stranded RNA binding (GO:0003727) 87 0 .03 - < 0.01 1.00E00 1.00E00 double-stranded RNA adenosine deaminase activity (GO:0003726) 6 0 .00 - < 0.01 1.00E00 1.00E00 double-stranded RNA binding (GO:0003725) 76 0 .02 - < 0.01 1.00E00 1.00E00 RNA helicase activity (GO:0003724) 77 0 .02 - < 0.01 1.00E00 1.00E00 RNA binding (GO:0003723) 1681 0 .49 - < 0.01 1.00E00 1.00E00 telomerase activity (GO:0003720) 17 0 .00 - < 0.01 1.00E00 1.00E00 chemokine receptor antagonist activity (GO:0046817) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity (GO:0106335) 2 0 .00 - < 0.01 1.00E00 1.00E00 amyloid-beta binding (GO:0001540) 82 0 .02 - < 0.01 1.00E00 1.00E00 host cell surface binding (GO:0046812) 1 0 .00 - < 0.01 1.00E00 1.00E00 deaminated base DNA N-glycosylase activity (GO:0097506) 4 0 .00 - < 0.01 1.00E00 1.00E00 sialate 9-O-acetylesterase activity (GO:0106330) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone deacetylase inhibitor activity (GO:0046811) 2 0 .00 - < 0.01 1.00E00 1.00E00 leukotriene-B4 20-monooxygenase activity (GO:0050051) 4 0 .00 - < 0.01 1.00E00 1.00E00 transcription corepressor activity (GO:0003714) 201 0 .06 - < 0.01 1.00E00 1.00E00 succinate-semialdehyde dehydrogenase [NAD(P)+] activity (GO:0009013) 1 0 .00 - < 0.01 1.00E00 1.00E00 transcription coactivator activity (GO:0003713) 280 0 .08 - < 0.01 1.00E00 1.00E00 transcription coregulator activity (GO:0003712) 515 0 .15 - < 0.01 1.00E00 1.00E00 L-phenylalaine oxidase activity (GO:0106329) 1 0 .00 - < 0.01 1.00E00 1.00E00 transcription elongation factor activity (GO:0003711) 8 0 .00 - < 0.01 1.00E00 1.00E00 dermatan 4-sulfotransferase activity (GO:0001537) 5 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-21 receptor activity (GO:0001532) 1 0 .00 - < 0.01 1.00E00 1.00E00 S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity (GO:0106322) 1 0 .00 - < 0.01 1.00E00 1.00E00 S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity (GO:0106321) 1 0 .00 - < 0.01 1.00E00 1.00E00 lipopolysaccharide binding (GO:0001530) 40 0 .01 - < 0.01 1.00E00 1.00E00 hemoglobin binding (GO:0030492) 9 0 .00 - < 0.01 1.00E00 1.00E00 intermediate conductance calcium-activated potassium channel activity (GO:0022894) 1 0 .00 - < 0.01 1.00E00 1.00E00 delta7-sterol 5(6)-desaturase activity (GO:0050046) 1 0 .00 - < 0.01 1.00E00 1.00E00 inorganic cation transmembrane transporter activity (GO:0022890) 615 0 .18 - < 0.01 1.00E00 1.00E00 ACP phosphopantetheine attachment site binding (GO:0044620) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-methyltransferase activity (GO:0009008) 6 0 .00 - < 0.01 1.00E00 1.00E00 site-specific DNA-methyltransferase (adenine-specific) activity (GO:0009007) 2 0 .00 - < 0.01 1.00E00 1.00E00 nuclear steroid receptor activity (GO:0003707) 26 0 .01 - < 0.01 1.00E00 1.00E00 selenocysteine lyase activity (GO:0009000) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-binding transcription factor activity (GO:0003700) 1416 0 .41 - < 0.01 1.00E00 1.00E00 methylenetetrahydrofolate reductase (NADPH) activity (GO:0106313) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein serine kinase activity (GO:0106310) 362 0 .11 - < 0.01 1.00E00 1.00E00 L-xylulose reductase (NADPH) activity (GO:0050038) 1 0 .00 - < 0.01 1.00E00 1.00E00 macromolecule transmembrane transporter activity (GO:0022884) 32 0 .01 - < 0.01 1.00E00 1.00E00 zinc efflux transmembrane transporter activity (GO:0022883) 2 0 .00 - < 0.01 1.00E00 1.00E00 FMN transmembrane transporter activity (GO:0044610) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-pipecolate oxidase activity (GO:0050031) 1 0 .00 - < 0.01 1.00E00 1.00E00 progesterone 21-hydroxylase activity (GO:0106309) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylglucosamine 6-O-sulfotransferase activity (GO:0001517) 7 0 .00 - < 0.01 1.00E00 1.00E00 opioid peptide activity (GO:0001515) 4 0 .00 - < 0.01 1.00E00 1.00E00 dihydronicotinamide riboside quinone reductase activity (GO:0001512) 1 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate 5,6-epoxygenase activity (GO:0106301) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein adenylylhydrolase activity (GO:0044603) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-fuconate dehydratase activity (GO:0050023) 1 0 .00 - < 0.01 1.00E00 1.00E00 itaconyl-CoA hydratase activity (GO:0050011) 1 0 .00 - < 0.01 1.00E00 1.00E00 molybdopterin molybdotransferase activity (GO:0061599) 1 0 .00 - < 0.01 1.00E00 1.00E00 molybdopterin adenylyltransferase activity (GO:0061598) 1 0 .00 - < 0.01 1.00E00 1.00E00 alanine transmembrane transporter activity (GO:0022858) 16 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane transporter activity (GO:0022857) 1136 0 .33 - < 0.01 1.00E00 1.00E00 active monoatomic ion transmembrane transporter activity (GO:0022853) 116 0 .03 - < 0.01 1.00E00 1.00E00 glycine-gated chloride ion channel activity (GO:0022852) 2 0 .00 - < 0.01 1.00E00 1.00E00 GABA-gated chloride ion channel activity (GO:0022851) 18 0 .01 - < 0.01 1.00E00 1.00E00 serotonin-gated monoatomic cation channel activity (GO:0022850) 7 0 .00 - < 0.01 1.00E00 1.00E00 calcium-dependent protein serine/threonine phosphatase regulator activity (GO:0008597) 5 0 .00 - < 0.01 1.00E00 1.00E00 glutamate-gated calcium ion channel activity (GO:0022849) 9 0 .00 - < 0.01 1.00E00 1.00E00 acetylcholine-gated monoatomic cation-selective channel activity (GO:0022848) 17 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated monoatomic cation channel activity (GO:0022843) 143 0 .04 - < 0.01 1.00E00 1.00E00 narrow pore channel activity (GO:0022842) 19 0 .01 - < 0.01 1.00E00 1.00E00 potassium ion leak channel activity (GO:0022841) 16 0 .00 - < 0.01 1.00E00 1.00E00 leak channel activity (GO:0022840) 19 0 .01 - < 0.01 1.00E00 1.00E00 K63-linked deubiquitinase activity (GO:0061578) 17 0 .00 - < 0.01 1.00E00 1.00E00 cyclin-dependent protein serine/threonine kinase activator activity (GO:0061575) 12 0 .00 - < 0.01 1.00E00 1.00E00 monoatomic ion-gated channel activity (GO:0022839) 30 0 .01 - < 0.01 1.00E00 1.00E00 gated channel activity (GO:0022836) 316 0 .09 - < 0.01 1.00E00 1.00E00 transmitter-gated channel activity (GO:0022835) 63 0 .02 - < 0.01 1.00E00 1.00E00 ligand-gated channel activity (GO:0022834) 187 0 .05 - < 0.01 1.00E00 1.00E00 voltage-gated channel activity (GO:0022832) 174 0 .05 - < 0.01 1.00E00 1.00E00 all-trans-retinol binding (GO:1904768) 3 0 .00 - < 0.01 1.00E00 1.00E00 superoxide-generating NADPH oxidase activator activity (GO:0016176) 11 0 .00 - < 0.01 1.00E00 1.00E00 superoxide-generating NAD(P)H oxidase activity (GO:0016175) 11 0 .00 - < 0.01 1.00E00 1.00E00 JUN kinase phosphatase activity (GO:0008579) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD(P)H oxidase H2O2-forming activity (GO:0016174) 9 0 .00 - < 0.01 1.00E00 1.00E00 kynureninase activity (GO:0030429) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-15 receptor binding (GO:0016170) 1 0 .00 - < 0.01 1.00E00 1.00E00 plus-end-directed microtubule motor activity (GO:0008574) 19 0 .01 - < 0.01 1.00E00 1.00E00 wide pore channel activity (GO:0022829) 37 0 .01 - < 0.01 1.00E00 1.00E00 transmitter-gated monoatomic ion channel activity (GO:0022824) 63 0 .02 - < 0.01 1.00E00 1.00E00 misfolded protein binding (GO:0051787) 17 0 .00 - < 0.01 1.00E00 1.00E00 all-trans-retinol 13,14-reductase activity (GO:0051786) 1 0 .00 - < 0.01 1.00E00 1.00E00 solute:potassium antiporter activity (GO:0022821) 19 0 .01 - < 0.01 1.00E00 1.00E00 glial cell-derived neurotrophic factor receptor activity (GO:0016167) 5 0 .00 - < 0.01 1.00E00 1.00E00 linoleate 13S-lipoxygenase activity (GO:0016165) 3 0 .00 - < 0.01 1.00E00 1.00E00 minus-end-directed microtubule motor activity (GO:0008569) 17 0 .00 - < 0.01 1.00E00 1.00E00 microtubule severing ATPase activity (GO:0008568) 9 0 .00 - < 0.01 1.00E00 1.00E00 amylase activity (GO:0016160) 6 0 .00 - < 0.01 1.00E00 1.00E00 peptidase inhibitor activity (GO:0030414) 177 0 .05 - < 0.01 1.00E00 1.00E00 formimidoyltetrahydrofolate cyclodeaminase activity (GO:0030412) 1 0 .00 - < 0.01 1.00E00 1.00E00 membrane potential driven uniporter activity (GO:0022810) 5 0 .00 - < 0.01 1.00E00 1.00E00 (S)-3-amino-2-methylpropionate transaminase activity (GO:0047298) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcium-dependent cysteine-type endopeptidase inhibitor activity (GO:0010859) 1 0 .00 - < 0.01 1.00E00 1.00E00 3-phytase activity (GO:0016158) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcium-dependent protein kinase regulator activity (GO:0010858) 3 0 .00 - < 0.01 1.00E00 1.00E00 adenylate cyclase activator activity (GO:0010856) 4 0 .00 - < 0.01 1.00E00 1.00E00 formyltetrahydrofolate dehydrogenase activity (GO:0016155) 2 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type xenobiotic transporter activity (GO:0008559) 14 0 .00 - < 0.01 1.00E00 1.00E00 adenylate cyclase inhibitor activity (GO:0010855) 4 0 .00 - < 0.01 1.00E00 1.00E00 pyrimidine-nucleoside phosphorylase activity (GO:0016154) 3 0 .00 - < 0.01 1.00E00 1.00E00 lactosylceramide alpha-2,3-sialyltransferase activity (GO:0047291) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenylate cyclase regulator activity (GO:0010854) 11 0 .00 - < 0.01 1.00E00 1.00E00 urocanate hydratase activity (GO:0016153) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity (GO:0047290) 2 0 .00 - < 0.01 1.00E00 1.00E00 cyclase activator activity (GO:0010853) 11 0 .00 - < 0.01 1.00E00 1.00E00 glycogen synthase activity, transferring glucose-1-phosphate (GO:0061547) 2 0 .00 - < 0.01 1.00E00 1.00E00 P-type potassium transmembrane transporter activity (GO:0008556) 8 0 .00 - < 0.01 1.00E00 1.00E00 cyclase inhibitor activity (GO:0010852) 5 0 .00 - < 0.01 1.00E00 1.00E00 nickel cation binding (GO:0016151) 5 0 .00 - < 0.01 1.00E00 1.00E00 glutamate formimidoyltransferase activity (GO:0030409) 1 0 .00 - < 0.01 1.00E00 1.00E00 cyclase regulator activity (GO:0010851) 19 0 .01 - < 0.01 1.00E00 1.00E00 translation release factor activity, codon nonspecific (GO:0016150) 1 0 .00 - < 0.01 1.00E00 1.00E00 P-type sodium transporter activity (GO:0008554) 7 0 .00 - < 0.01 1.00E00 1.00E00 P-type proton-exporting transporter activity (GO:0008553) 3 0 .00 - < 0.01 1.00E00 1.00E00 3-demethylubiquinol 3-O-methyltransferase activity (GO:0061542) 1 0 .00 - < 0.01 1.00E00 1.00E00 active transmembrane transporter activity (GO:0022804) 456 0 .13 - < 0.01 1.00E00 1.00E00 passive transmembrane transporter activity (GO:0022803) 508 0 .15 - < 0.01 1.00E00 1.00E00 calcium-dependent cysteine-type endopeptidase activity (GO:0004198) 16 0 .00 - < 0.01 1.00E00 1.00E00 inositol trisphosphate kinase activity (GO:0051766) 5 0 .00 - < 0.01 1.00E00 1.00E00 cysteine-type endopeptidase activity (GO:0004197) 86 0 .03 - < 0.01 1.00E00 1.00E00 inositol tetrakisphosphate kinase activity (GO:0051765) 2 0 .00 - < 0.01 1.00E00 1.00E00 aspartic-type endopeptidase activity (GO:0004190) 38 0 .01 - < 0.01 1.00E00 1.00E00 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase (GO:0047288) 3 0 .00 - < 0.01 1.00E00 1.00E00 translation release factor activity, codon specific (GO:0016149) 4 0 .00 - < 0.01 1.00E00 1.00E00 recombination hotspot binding (GO:0010844) 1 0 .00 - < 0.01 1.00E00 1.00E00 nicotinamide phosphoribosyltransferase activity (GO:0047280) 1 0 .00 - < 0.01 1.00E00 1.00E00 JUN kinase kinase activity (GO:0008545) 8 0 .00 - < 0.01 1.00E00 1.00E00 serine-type carboxypeptidase activity (GO:0004185) 5 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,4-mannosyltransferase activity (GO:0051751) 1 0 .00 - < 0.01 1.00E00 1.00E00 delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity (GO:0051750) 1 0 .00 - < 0.01 1.00E00 1.00E00 metallocarboxypeptidase activity (GO:0004181) 34 0 .01 - < 0.01 1.00E00 1.00E00 carboxypeptidase activity (GO:0004180) 48 0 .01 - < 0.01 1.00E00 1.00E00 globoside alpha-N-acetylgalactosaminyltransferase activity (GO:0047277) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetyllactosaminide 3-alpha-galactosyltransferase activity (GO:0047276) 1 0 .00 - < 0.01 1.00E00 1.00E00 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity (GO:0047273) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidized purine nucleobase lesion DNA N-glycosylase activity (GO:0008534) 3 0 .00 - < 0.01 1.00E00 1.00E00 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity (GO:0008532) 5 0 .00 - < 0.01 1.00E00 1.00E00 small RNA 2'-O-methyltransferase activity (GO:0090486) 3 0 .00 - < 0.01 1.00E00 1.00E00 riboflavin kinase activity (GO:0008531) 1 0 .00 - < 0.01 1.00E00 1.00E00 vitamin transmembrane transporter activity (GO:0090482) 34 0 .01 - < 0.01 1.00E00 1.00E00 UTP-monosaccharide-1-phosphate uridylyltransferase activity (GO:0051748) 1 0 .00 - < 0.01 1.00E00 1.00E00 cytosine C-5 DNA demethylase activity (GO:0051747) 1 0 .00 - < 0.01 1.00E00 1.00E00 aminopeptidase activity (GO:0004177) 40 0 .01 - < 0.01 1.00E00 1.00E00 ATP-dependent peptidase activity (GO:0004176) 7 0 .00 - < 0.01 1.00E00 1.00E00 endopeptidase activity (GO:0004175) 407 0 .12 - < 0.01 1.00E00 1.00E00 electron-transferring-flavoprotein dehydrogenase activity (GO:0004174) 2 0 .00 - < 0.01 1.00E00 1.00E00 beta-catenin destruction complex binding (GO:1904713) 2 0 .00 - < 0.01 1.00E00 1.00E00 dUTP diphosphatase activity (GO:0004170) 1 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled peptide receptor activity (GO:0008528) 124 0 .04 - < 0.01 1.00E00 1.00E00 taste receptor activity (GO:0008527) 28 0 .01 - < 0.01 1.00E00 1.00E00 phosphatidylinositol transfer activity (GO:0008526) 11 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylcholine transporter activity (GO:0008525) 18 0 .01 - < 0.01 1.00E00 1.00E00 sodium-dependent multivitamin transmembrane transporter activity (GO:0008523) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucose 6-phosphate:phosphate antiporter activity (GO:0061513) 3 0 .00 - < 0.01 1.00E00 1.00E00 acetyl-CoA transmembrane transporter activity (GO:0008521) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-ascorbate:sodium symporter activity (GO:0008520) 2 0 .00 - < 0.01 1.00E00 1.00E00 dolichyl-phosphate-mannose-protein mannosyltransferase activity (GO:0004169) 8 0 .00 - < 0.01 1.00E00 1.00E00 dolichol kinase activity (GO:0004168) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity (GO:0051736) 2 0 .00 - < 0.01 1.00E00 1.00E00 dopachrome isomerase activity (GO:0004167) 3 0 .00 - < 0.01 1.00E00 1.00E00 ATP-dependent polynucleotide 5'-hydroxyl-kinase activity (GO:0051734) 4 0 .00 - < 0.01 1.00E00 1.00E00 delta(3)-delta(2)-enoyl-CoA isomerase activity (GO:0004165) 4 0 .00 - < 0.01 1.00E00 1.00E00 diphosphomevalonate decarboxylase activity (GO:0004163) 1 0 .00 - < 0.01 1.00E00 1.00E00 polynucleotide 5'-hydroxyl-kinase activity (GO:0051731) 4 0 .00 - < 0.01 1.00E00 1.00E00 dimethylallyltranstransferase activity (GO:0004161) 2 0 .00 - < 0.01 1.00E00 1.00E00 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity (GO:0047256) 1 0 .00 - < 0.01 1.00E00 1.00E00 ammonium channel activity (GO:0008519) 10 0 .00 - < 0.01 1.00E00 1.00E00 folate:monoatomic anion antiporter activity (GO:0008518) 1 0 .00 - < 0.01 1.00E00 1.00E00 folic acid transmembrane transporter activity (GO:0008517) 4 0 .00 - < 0.01 1.00E00 1.00E00 2',3'-cyclic GMP-AMP binding (GO:0061507) 2 0 .00 - < 0.01 1.00E00 1.00E00 hexose uniporter activity (GO:0008516) 1 0 .00 - < 0.01 1.00E00 1.00E00 sucrose transmembrane transporter activity (GO:0008515) 4 0 .00 - < 0.01 1.00E00 1.00E00 organic anion transmembrane transporter activity (GO:0008514) 270 0 .08 - < 0.01 1.00E00 1.00E00 secondary active organic cation transmembrane transporter activity (GO:0008513) 1 0 .00 - < 0.01 1.00E00 1.00E00 sodium:potassium:chloride symporter activity (GO:0008511) 3 0 .00 - < 0.01 1.00E00 1.00E00 2',3'-cyclic GMP-AMP synthase activity (GO:0061501) 1 0 .00 - < 0.01 1.00E00 1.00E00 sodium:bicarbonate symporter activity (GO:0008510) 6 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity (GO:0035299) 1 0 .00 - < 0.01 1.00E00 1.00E00 dihydropyrimidinase activity (GO:0004157) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD transmembrane transporter activity (GO:0051724) 5 0 .00 - < 0.01 1.00E00 1.00E00 6,7-dihydropteridine reductase activity (GO:0004155) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein methylesterase activity (GO:0051723) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein C-terminal methylesterase activity (GO:0051722) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein phosphatase 2A binding (GO:0051721) 30 0 .01 - < 0.01 1.00E00 1.00E00 dihydroorotate dehydrogenase activity (GO:0004152) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates (GO:0051720) 3 0 .00 - < 0.01 1.00E00 1.00E00 dihydroorotase activity (GO:0004151) 2 0 .00 - < 0.01 1.00E00 1.00E00 monoatomic anion transmembrane transporter activity (GO:0008509) 148 0 .04 - < 0.01 1.00E00 1.00E00 bile acid:sodium symporter activity (GO:0008508) 6 0 .00 - < 0.01 1.00E00 1.00E00 sodium:iodide symporter activity (GO:0008507) 1 0 .00 - < 0.01 1.00E00 1.00E00 sucrose:proton symporter activity (GO:0008506) 4 0 .00 - < 0.01 1.00E00 1.00E00 monoamine transmembrane transporter activity (GO:0008504) 12 0 .00 - < 0.01 1.00E00 1.00E00 benzodiazepine receptor activity (GO:0008503) 11 0 .00 - < 0.01 1.00E00 1.00E00 melatonin receptor activity (GO:0008502) 4 0 .00 - < 0.01 1.00E00 1.00E00 DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates (GO:0051719) 3 0 .00 - < 0.01 1.00E00 1.00E00 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates (GO:0051718) 1 0 .00 - < 0.01 1.00E00 1.00E00 dihydrolipoyllysine-residue succinyltransferase activity (GO:0004149) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity (GO:0051717) 2 0 .00 - < 0.01 1.00E00 1.00E00 dihydrolipoyl dehydrogenase (NADH) activity (GO:0004148) 1 0 .00 - < 0.01 1.00E00 1.00E00 dihydrofolate reductase activity (GO:0004146) 2 0 .00 - < 0.01 1.00E00 1.00E00 diamine N-acetyltransferase activity (GO:0004145) 4 0 .00 - < 0.01 1.00E00 1.00E00 diacylglycerol O-acyltransferase activity (GO:0004144) 7 0 .00 - < 0.01 1.00E00 1.00E00 ATP-dependent diacylglycerol kinase activity (GO:0004143) 11 0 .00 - < 0.01 1.00E00 1.00E00 diacylglycerol cholinephosphotransferase activity (GO:0004142) 3 0 .00 - < 0.01 1.00E00 1.00E00 dephospho-CoA kinase activity (GO:0004140) 2 0 .00 - < 0.01 1.00E00 1.00E00 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity (GO:0047238) 6 0 .00 - < 0.01 1.00E00 1.00E00 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity (GO:0047237) 3 0 .00 - < 0.01 1.00E00 1.00E00 lipoteichoic acid immune receptor activity (GO:0070892) 1 0 .00 - < 0.01 1.00E00 1.00E00 lipoteichoic acid binding (GO:0070891) 6 0 .00 - < 0.01 1.00E00 1.00E00 deoxyribose-phosphate aldolase activity (GO:0004139) 1 0 .00 - < 0.01 1.00E00 1.00E00 ethanol binding (GO:0035276) 2 0 .00 - < 0.01 1.00E00 1.00E00 deoxyguanosine kinase activity (GO:0004138) 2 0 .00 - < 0.01 1.00E00 1.00E00 deoxycytidine kinase activity (GO:0004137) 2 0 .00 - < 0.01 1.00E00 1.00E00 deoxyadenosine kinase activity (GO:0004136) 3 0 .00 - < 0.01 1.00E00 1.00E00 amylo-alpha-1,6-glucosidase activity (GO:0004135) 1 0 .00 - < 0.01 1.00E00 1.00E00 4-alpha-glucanotransferase activity (GO:0004134) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycogen debranching enzyme activity (GO:0004133) 1 0 .00 - < 0.01 1.00E00 1.00E00 dCMP deaminase activity (GO:0004132) 2 0 .00 - < 0.01 1.00E00 1.00E00 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity (GO:0047225) 1 0 .00 - < 0.01 1.00E00 1.00E00 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity (GO:0047224) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity (GO:0047223) 3 0 .00 - < 0.01 1.00E00 1.00E00 E-box binding (GO:0070888) 59 0 .02 - < 0.01 1.00E00 1.00E00 galactosylxylosylprotein 3-beta-galactosyltransferase activity (GO:0047220) 1 0 .00 - < 0.01 1.00E00 1.00E00 pre-miRNA binding (GO:0070883) 9 0 .00 - < 0.01 1.00E00 1.00E00 oleoyl-CoA ligase activity (GO:0090434) 4 0 .00 - < 0.01 1.00E00 1.00E00 palmitoyl-CoA ligase activity (GO:0090433) 3 0 .00 - < 0.01 1.00E00 1.00E00 cytochrome-c oxidase activity (GO:0004129) 13 0 .00 - < 0.01 1.00E00 1.00E00 cytochrome-b5 reductase activity, acting on NAD(P)H (GO:0004128) 6 0 .00 - < 0.01 1.00E00 1.00E00 (d)CMP kinase activity (GO:0004127) 6 0 .00 - < 0.01 1.00E00 1.00E00 cytidine deaminase activity (GO:0004126) 12 0 .00 - < 0.01 1.00E00 1.00E00 cystathionine gamma-lyase activity (GO:0004123) 1 0 .00 - < 0.01 1.00E00 1.00E00 cystathionine beta-synthase activity (GO:0004122) 1 0 .00 - < 0.01 1.00E00 1.00E00 primary miRNA binding (GO:0070878) 9 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled ATP receptor activity (GO:0045031) 2 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled UTP receptor activity (GO:0045030) 3 0 .00 - < 0.01 1.00E00 1.00E00 nuclear glucocorticoid receptor binding (GO:0035259) 12 0 .00 - < 0.01 1.00E00 1.00E00 thiamine pyrophosphate transmembrane transporter activity (GO:0090422) 2 0 .00 - < 0.01 1.00E00 1.00E00 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity (GO:0004119) 6 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled glutamate receptor binding (GO:0035256) 10 0 .00 - < 0.01 1.00E00 1.00E00 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (GO:0004118) 7 0 .00 - < 0.01 1.00E00 1.00E00 ionotropic glutamate receptor binding (GO:0035255) 27 0 .01 - < 0.01 1.00E00 1.00E00 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity (GO:0004117) 11 0 .00 - < 0.01 1.00E00 1.00E00 glutamate receptor binding (GO:0035254) 49 0 .01 - < 0.01 1.00E00 1.00E00 3',5'-cyclic-AMP phosphodiesterase activity (GO:0004115) 24 0 .01 - < 0.01 1.00E00 1.00E00 UDP-xylosyltransferase activity (GO:0035252) 11 0 .00 - < 0.01 1.00E00 1.00E00 3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114) 24 0 .01 - < 0.01 1.00E00 1.00E00 UDP-glucosyltransferase activity (GO:0035251) 12 0 .00 - < 0.01 1.00E00 1.00E00 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity (GO:0004113) 1 0 .00 - < 0.01 1.00E00 1.00E00 UDP-galactosyltransferase activity (GO:0035250) 29 0 .01 - < 0.01 1.00E00 1.00E00 cyclic-nucleotide phosphodiesterase activity (GO:0004112) 26 0 .01 - < 0.01 1.00E00 1.00E00 creatine kinase activity (GO:0004111) 5 0 .00 - < 0.01 1.00E00 1.00E00 monocarboxylate:sodium symporter activity (GO:0140161) 15 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled UDP receptor activity (GO:0045029) 2 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled purinergic nucleotide receptor activity (GO:0045028) 13 0 .00 - < 0.01 1.00E00 1.00E00 DNA end binding (GO:0045027) 3 0 .00 - < 0.01 1.00E00 1.00E00 nicotinate transmembrane transporter activity (GO:0090416) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,4-N-acetylgalactosaminyltransferase activity (GO:0035248) 1 0 .00 - < 0.01 1.00E00 1.00E00 starch binding (GO:2001070) 3 0 .00 - < 0.01 1.00E00 1.00E00 coproporphyrinogen oxidase activity (GO:0004109) 2 0 .00 - < 0.01 1.00E00 1.00E00 citrate (Si)-synthase activity (GO:0004108) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-arginine omega-N symmetric methyltransferase activity (GO:0035243) 4 0 .00 - < 0.01 1.00E00 1.00E00 choline-phosphate cytidylyltransferase activity (GO:0004105) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein-arginine omega-N asymmetric methyltransferase activity (GO:0035242) 7 0 .00 - < 0.01 1.00E00 1.00E00 cholinesterase activity (GO:0004104) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein-arginine omega-N monomethyltransferase activity (GO:0035241) 5 0 .00 - < 0.01 1.00E00 1.00E00 choline kinase activity (GO:0004103) 2 0 .00 - < 0.01 1.00E00 1.00E00 dopamine binding (GO:0035240) 7 0 .00 - < 0.01 1.00E00 1.00E00 choline O-acetyltransferase activity (GO:0004102) 1 0 .00 - < 0.01 1.00E00 1.00E00 myosin VI light chain binding (GO:0070856) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycogen binding (GO:2001069) 9 0 .00 - < 0.01 1.00E00 1.00E00 myosin VI binding (GO:0070853) 3 0 .00 - < 0.01 1.00E00 1.00E00 malonyl-CoA synthetase activity (GO:0090409) 1 0 .00 - < 0.01 1.00E00 1.00E00 growth factor receptor binding (GO:0070851) 139 0 .04 - < 0.01 1.00E00 1.00E00 mannan binding (GO:2001065) 2 0 .00 - < 0.01 1.00E00 1.00E00 nucleocytoplasmic carrier activity (GO:0140142) 32 0 .01 - < 0.01 1.00E00 1.00E00 dynein complex binding (GO:0070840) 24 0 .01 - < 0.01 1.00E00 1.00E00 glutamate-cysteine ligase catalytic subunit binding (GO:0035226) 1 0 .00 - < 0.01 1.00E00 1.00E00 mechanosensitive monoatomic cation channel activity (GO:0140135) 10 0 .00 - < 0.01 1.00E00 1.00E00 sweet taste receptor activity (GO:0033041) 2 0 .00 - < 0.01 1.00E00 1.00E00 sour taste receptor activity (GO:0033040) 2 0 .00 - < 0.01 1.00E00 1.00E00 restriction endodeoxyribonuclease activity (GO:0015666) 1 0 .00 - < 0.01 1.00E00 1.00E00 alcohol transmembrane transporter activity (GO:0015665) 8 0 .00 - < 0.01 1.00E00 1.00E00 P-type ion transporter activity (GO:0015662) 25 0 .01 - < 0.01 1.00E00 1.00E00 structural molecule activity conferring elasticity (GO:0097493) 11 0 .00 - < 0.01 1.00E00 1.00E00 bitter taste receptor activity (GO:0033038) 22 0 .01 - < 0.01 1.00E00 1.00E00 branched-chain amino acid transmembrane transporter activity (GO:0015658) 10 0 .00 - < 0.01 1.00E00 1.00E00 branched-chain amino acid:sodium symporter activity (GO:0015657) 2 0 .00 - < 0.01 1.00E00 1.00E00 alanine:sodium symporter activity (GO:0015655) 4 0 .00 - < 0.01 1.00E00 1.00E00 virion binding (GO:0046790) 9 0 .00 - < 0.01 1.00E00 1.00E00 quaternary ammonium group transmembrane transporter activity (GO:0015651) 13 0 .00 - < 0.01 1.00E00 1.00E00 lactate:proton symporter activity (GO:0015650) 2 0 .00 - < 0.01 1.00E00 1.00E00 transcription regulator activity (GO:0140110) 1923 0 .56 - < 0.01 1.00E00 1.00E00 single-stranded DNA binding (GO:0003697) 123 0 .04 - < 0.01 1.00E00 1.00E00 satellite DNA binding (GO:0003696) 4 0 .00 - < 0.01 1.00E00 1.00E00 menaquinone-dependent protoporphyrinogen oxidase activity (GO:0070819) 1 0 .00 - < 0.01 1.00E00 1.00E00 protoporphyrinogen oxidase activity (GO:0070818) 1 0 .00 - < 0.01 1.00E00 1.00E00 left-handed Z-DNA binding (GO:0003692) 1 0 .00 - < 0.01 1.00E00 1.00E00 double-stranded telomeric DNA binding (GO:0003691) 9 0 .00 - < 0.01 1.00E00 1.00E00 double-stranded DNA binding (GO:0003690) 1611 0 .47 - < 0.01 1.00E00 1.00E00 host cell surface receptor binding (GO:0046789) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-lysine 5-dioxygenase activity (GO:0070815) 4 0 .00 - < 0.01 1.00E00 1.00E00 peptidoglycan transmembrane transporter activity (GO:0015647) 2 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid ligase activity (GO:0015645) 25 0 .01 - < 0.01 1.00E00 1.00E00 toxic substance binding (GO:0015643) 10 0 .00 - < 0.01 1.00E00 1.00E00 cyclin-dependent protein kinase activity (GO:0097472) 29 0 .01 - < 0.01 1.00E00 1.00E00 RISC complex binding (GO:1905172) 4 0 .00 - < 0.01 1.00E00 1.00E00 molecular carrier activity (GO:0140104) 104 0 .03 - < 0.01 1.00E00 1.00E00 catalytic activity, acting on a glycoprotein (GO:0140103) 22 0 .01 - < 0.01 1.00E00 1.00E00 catalytic activity, acting on a rRNA (GO:0140102) 23 0 .01 - < 0.01 1.00E00 1.00E00 catalytic activity, acting on a tRNA (GO:0140101) 137 0 .04 - < 0.01 1.00E00 1.00E00 DNA clamp loader activity (GO:0003689) 9 0 .00 - < 0.01 1.00E00 1.00E00 DNA replication origin binding (GO:0003688) 16 0 .00 - < 0.01 1.00E00 1.00E00 damaged DNA binding (GO:0003684) 75 0 .02 - < 0.01 1.00E00 1.00E00 chromatin binding (GO:0003682) 615 0 .18 - < 0.01 1.00E00 1.00E00 bent DNA binding (GO:0003681) 2 0 .00 - < 0.01 1.00E00 1.00E00 minor groove of adenine-thymine-rich DNA binding (GO:0003680) 10 0 .00 - < 0.01 1.00E00 1.00E00 NADPH oxidase H202-forming activity (GO:0106294) 5 0 .00 - < 0.01 1.00E00 1.00E00 NADH oxidase H202-forming activity (GO:0106293) 2 0 .00 - < 0.01 1.00E00 1.00E00 superoxide-generating NADPH oxidase activity (GO:0106292) 5 0 .00 - < 0.01 1.00E00 1.00E00 short-chain fatty acid transmembrane transporter activity (GO:0015636) 3 0 .00 - < 0.01 1.00E00 1.00E00 tubulin binding (GO:0015631) 391 0 .11 - < 0.01 1.00E00 1.00E00 DNA helicase activity (GO:0003678) 74 0 .02 - < 0.01 1.00E00 1.00E00 DNA binding (GO:0003677) 2519 0 .73 - < 0.01 1.00E00 1.00E00 nucleic acid binding (GO:0003676) 3991 0 1.16 - < 0.01 6.04E-01 1.00E00 molecular_function (GO:0003674) 18280 6 5.33 + 1.13 1.00E00 1.00E00 ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity (GO:0106283) 1 0 .00 - < 0.01 1.00E00 1.00E00 isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity (GO:0106282) 1 0 .00 - < 0.01 1.00E00 1.00E00 chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity (GO:0106281) 1 0 .00 - < 0.01 1.00E00 1.00E00 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity (GO:0120539) 1 0 .00 - < 0.01 1.00E00 1.00E00 dermatan sulfotransferase activity (GO:0120534) 6 0 .00 - < 0.01 1.00E00 1.00E00 prenyl diphosphate synthase activity (GO:0120531) 7 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (GO:0099626) 4 0 .00 - < 0.01 1.00E00 1.00E00 biliverdin reductase (NADP+) activity (GO:0106277) 1 0 .00 - < 0.01 1.00E00 1.00E00 biliberdin reductase (NAD+) activity (GO:0106276) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-protein-arginine ADP-ribosyltransferase activity (GO:0106274) 6 0 .00 - < 0.01 1.00E00 1.00E00 DNA translocase activity (GO:0015616) 5 0 .00 - < 0.01 1.00E00 1.00E00 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity (GO:0120521) 1 0 .00 - < 0.01 1.00E00 1.00E00 free fatty acid 2-hydroxylase activity (GO:0120520) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone binding (GO:0042393) 243 0 .07 - < 0.01 1.00E00 1.00E00 sphingosine-1-phosphate phosphatase activity (GO:0042392) 7 0 .00 - < 0.01 1.00E00 1.00E00 protein serine kinase activity (using GTP as donor) (GO:0106264) 1 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type fatty-acyl-CoA transporter activity (GO:0015607) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-acylglycerophosphoserine O-acyltransferase activity (GO:0106263) 4 0 .00 - < 0.01 1.00E00 1.00E00 spermidine transmembrane transporter activity (GO:0015606) 4 0 .00 - < 0.01 1.00E00 1.00E00 1-acylglycerophosphoethanolamine O-acyltransferase activity (GO:0106262) 4 0 .00 - < 0.01 1.00E00 1.00E00 tubulin N-terminal-methionine acetyltransferase activity (GO:0120519) 1 0 .00 - < 0.01 1.00E00 1.00E00 organophosphate ester transmembrane transporter activity (GO:0015605) 50 0 .01 - < 0.01 1.00E00 1.00E00 tRNA uridine(34) acetyltransferase activity (GO:0106261) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein N-terminal-methionine acetyltransferase activity (GO:0120518) 4 0 .00 - < 0.01 1.00E00 1.00E00 DNA-DNA tethering activity (GO:0106260) 5 0 .00 - < 0.01 1.00E00 1.00E00 inositol pentakisphosphate kinase activity (GO:0120517) 2 0 .00 - < 0.01 1.00E00 1.00E00 diacylglycerol lipase activity (GO:0120516) 3 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid-CoA ligase activity (GO:0120515) 25 0 .01 - < 0.01 1.00E00 1.00E00 microtubule lateral binding (GO:0099609) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-serine-phosphatidylcholine phosphatidyltransferase activity (GO:0106258) 1 0 .00 - < 0.01 1.00E00 1.00E00 ligand-gated calcium channel activity (GO:0099604) 28 0 .01 - < 0.01 1.00E00 1.00E00 hydroperoxy icosatetraenoate dehydratase activity (GO:0106256) 7 0 .00 - < 0.01 1.00E00 1.00E00 hydroperoxy icosatetraenoate isomerase activity (GO:0106255) 2 0 .00 - < 0.01 1.00E00 1.00E00 neurotransmitter receptor regulator activity (GO:0099602) 19 0 .01 - < 0.01 1.00E00 1.00E00 lipid sensor activity (GO:0106254) 1 0 .00 - < 0.01 1.00E00 1.00E00 hydroxypyruvate reductase (NADPH) activity (GO:0120509) 1 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid omega-1 hydroxylase activity (GO:0120502) 4 0 .00 - < 0.01 1.00E00 1.00E00 chemokine receptor binding (GO:0042379) 72 0 .02 - < 0.01 1.00E00 1.00E00 F-actin monooxygenase activity (GO:0120501) 3 0 .00 - < 0.01 1.00E00 1.00E00 L-serine-phosphatidylethanolamine phosphatidyltransferase activity (GO:0106245) 2 0 .00 - < 0.01 1.00E00 1.00E00 GTP cyclohydrolase binding (GO:0044549) 1 0 .00 - < 0.01 1.00E00 1.00E00 S100 protein binding (GO:0044548) 14 0 .00 - < 0.01 1.00E00 1.00E00 DNA topoisomerase binding (GO:0044547) 4 0 .00 - < 0.01 1.00E00 1.00E00 L-cystine L-cysteine-lyase (deaminating) (GO:0044540) 1 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate 12(R)-lipoxygenase activity (GO:0106237) 1 0 .00 - < 0.01 1.00E00 1.00E00 ceramide-1-phosphate phosphatase activity (GO:0106235) 3 0 .00 - < 0.01 1.00E00 1.00E00 active borate transmembrane transporter activity (GO:0046715) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD-dependent protein-lysine depropionylase activity (GO:0106231) 2 0 .00 - < 0.01 1.00E00 1.00E00 GDP-4-dehydro-D-rhamnose reductase activity (GO:0042356) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone glutaryltransferase activity (GO:0106229) 1 0 .00 - < 0.01 1.00E00 1.00E00 5'-3' RNA helicase activity (GO:0032574) 2 0 .00 - < 0.01 1.00E00 1.00E00 peptide glutaryltransferase activity (GO:0106228) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptide 2-hydroxyisobutyryltransferase activity (GO:0106226) 2 0 .00 - < 0.01 1.00E00 1.00E00 lactose binding (GO:0030395) 3 0 .00 - < 0.01 1.00E00 1.00E00 natural killer cell lectin-like receptor binding (GO:0046703) 8 0 .00 - < 0.01 1.00E00 1.00E00 lncRNA binding (GO:0106222) 23 0 .01 - < 0.01 1.00E00 1.00E00 dGTP binding (GO:0032567) 1 0 .00 - < 0.01 1.00E00 1.00E00 zinc ion sensor activity (GO:0106219) 1 0 .00 - < 0.01 1.00E00 1.00E00 dATP binding (GO:0032564) 1 0 .00 - < 0.01 1.00E00 1.00E00 guanyl ribonucleotide binding (GO:0032561) 404 0 .12 - < 0.01 1.00E00 1.00E00 guanyl deoxyribonucleotide binding (GO:0032560) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity (GO:0106211) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-17E receptor binding (GO:0030380) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K16 deacetylase activity, hydrolytic mechanism (GO:0034739) 10 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol O-acyltransferase activity (GO:0034736) 3 0 .00 - < 0.01 1.00E00 1.00E00 adenyl ribonucleotide binding (GO:0032559) 1522 0 .44 - < 0.01 1.00E00 1.00E00 adenyl deoxyribonucleotide binding (GO:0032558) 2 0 .00 - < 0.01 1.00E00 1.00E00 pyrimidine ribonucleotide binding (GO:0032557) 3 0 .00 - < 0.01 1.00E00 1.00E00 pyrimidine deoxyribonucleotide binding (GO:0032556) 1 0 .00 - < 0.01 1.00E00 1.00E00 purine ribonucleotide binding (GO:0032555) 1873 0 .55 - < 0.01 1.00E00 1.00E00 purine deoxyribonucleotide binding (GO:0032554) 3 0 .00 - < 0.01 1.00E00 1.00E00 ribonucleotide binding (GO:0032553) 1890 0 .55 - < 0.01 1.00E00 1.00E00 neurotensin receptor activity, non-G protein-coupled (GO:0030379) 1 0 .00 - < 0.01 1.00E00 1.00E00 deoxyribonucleotide binding (GO:0032552) 4 0 .00 - < 0.01 1.00E00 1.00E00 serine racemase activity (GO:0030378) 1 0 .00 - < 0.01 1.00E00 1.00E00 urokinase plasminogen activator receptor activity (GO:0030377) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucagon-like peptide 1 receptor activity (GO:0044508) 1 0 .00 - < 0.01 1.00E00 1.00E00 translation repressor activity (GO:0030371) 30 0 .01 - < 0.01 1.00E00 1.00E00 heparan sulfate N-acetylglucosaminyltransferase activity (GO:0042328) 2 0 .00 - < 0.01 1.00E00 1.00E00 orexin receptor binding (GO:0042324) 1 0 .00 - < 0.01 1.00E00 1.00E00 ribonucleoside binding (GO:0032549) 3 0 .00 - < 0.01 1.00E00 1.00E00 gamma-glutamyl-peptidase activity (GO:0034722) 1 0 .00 - < 0.01 1.00E00 1.00E00 guanine nucleotide transmembrane transporter activity (GO:0001409) 5 0 .00 - < 0.01 1.00E00 1.00E00 ICAM-3 receptor activity (GO:0030369) 3 0 .00 - < 0.01 1.00E00 1.00E00 sulfiredoxin activity (GO:0032542) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-17 receptor activity (GO:0030368) 8 0 .00 - < 0.01 1.00E00 1.00E00 molybdopterin synthase activity (GO:0030366) 1 0 .00 - < 0.01 1.00E00 1.00E00 type III transforming growth factor beta receptor binding (GO:0034714) 4 0 .00 - < 0.01 1.00E00 1.00E00 type I transforming growth factor beta receptor binding (GO:0034713) 11 0 .00 - < 0.01 1.00E00 1.00E00 inhibin binding (GO:0034711) 4 0 .00 - < 0.01 1.00E00 1.00E00 melanin-concentrating hormone activity (GO:0030354) 3 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity (GO:0030352) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity (GO:0030351) 2 0 .00 - < 0.01 1.00E00 1.00E00 iron-responsive element binding (GO:0030350) 3 0 .00 - < 0.01 1.00E00 1.00E00 phosphate ion binding (GO:0042301) 12 0 .00 - < 0.01 1.00E00 1.00E00 peptide transmembrane transporter activity (GO:1904680) 8 0 .00 - < 0.01 1.00E00 1.00E00 tripeptidase activity (GO:0034701) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity (GO:0008499) 12 0 .00 - < 0.01 1.00E00 1.00E00 protoheme IX farnesyltransferase activity (GO:0008495) 1 0 .00 - < 0.01 1.00E00 1.00E00 syntaxin-3 binding (GO:0030348) 2 0 .00 - < 0.01 1.00E00 1.00E00 translation activator activity (GO:0008494) 14 0 .00 - < 0.01 1.00E00 1.00E00 tetracycline transmembrane transporter activity (GO:0008493) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein phosphatase 2B binding (GO:0030346) 7 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of tooth enamel (GO:0030345) 6 0 .00 - < 0.01 1.00E00 1.00E00 vitamin D3 25-hydroxylase activity (GO:0030343) 4 0 .00 - < 0.01 1.00E00 1.00E00 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity (GO:0030342) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA demethylase activity (GO:1990984) 2 0 .00 - < 0.01 1.00E00 1.00E00 alpha-aminoacyl-tRNA binding (GO:1904678) 3 0 .00 - < 0.01 1.00E00 1.00E00 connexin binding (GO:0071253) 5 0 .00 - < 0.01 1.00E00 1.00E00 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity (GO:0008489) 3 0 .00 - < 0.01 1.00E00 1.00E00 gamma-glutamyl carboxylase activity (GO:0008488) 1 0 .00 - < 0.01 1.00E00 1.00E00 diphosphoinositol-polyphosphate diphosphatase activity (GO:0008486) 5 0 .00 - < 0.01 1.00E00 1.00E00 CMP-N-acetylneuraminate monooxygenase activity (GO:0030338) 1 0 .00 - < 0.01 1.00E00 1.00E00 sulfuric ester hydrolase activity (GO:0008484) 17 0 .00 - < 0.01 1.00E00 1.00E00 DNA polymerase processivity factor activity (GO:0030337) 3 0 .00 - < 0.01 1.00E00 1.00E00 transaminase activity (GO:0008483) 25 0 .01 - < 0.01 1.00E00 1.00E00 sulfite oxidase activity (GO:0008482) 1 0 .00 - < 0.01 1.00E00 1.00E00 sphingosine kinase activity (GO:0008481) 3 0 .00 - < 0.01 1.00E00 1.00E00 sarcosine dehydrogenase activity (GO:0008480) 1 0 .00 - < 0.01 1.00E00 1.00E00 cyclin binding (GO:0030332) 34 0 .01 - < 0.01 1.00E00 1.00E00 nuclear estrogen receptor binding (GO:0030331) 40 0 .01 - < 0.01 1.00E00 1.00E00 tRNA-guanosine(34) queuine transglycosylase activity (GO:0008479) 2 0 .00 - < 0.01 1.00E00 1.00E00 pyridoxal kinase activity (GO:0008478) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-tyrosine sulfotransferase activity (GO:0008476) 2 0 .00 - < 0.01 1.00E00 1.00E00 procollagen-lysine 5-dioxygenase activity (GO:0008475) 3 0 .00 - < 0.01 1.00E00 1.00E00 palmitoyl-(protein) hydrolase activity (GO:0008474) 14 0 .00 - < 0.01 1.00E00 1.00E00 muramyl dipeptide binding (GO:0032500) 1 0 .00 - < 0.01 1.00E00 1.00E00 O-acetyl-ADP-ribose deacetylase activity (GO:0061463) 4 0 .00 - < 0.01 1.00E00 1.00E00 3-methylbutanoyl-CoA dehydrogenase activity (GO:0008470) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase III general transcription initiation factor activity (GO:0000995) 12 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase III core binding (GO:0000994) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II complex binding (GO:0000993) 36 0 .01 - < 0.01 1.00E00 1.00E00 RNA polymerase III cis-regulatory region sequence-specific DNA binding (GO:0000992) 7 0 .00 - < 0.01 1.00E00 1.00E00 histone arginine N-methyltransferase activity (GO:0008469) 3 0 .00 - < 0.01 1.00E00 1.00E00 L-arginine transmembrane transporter activity (GO:0061459) 13 0 .00 - < 0.01 1.00E00 1.00E00 [heparan sulfate]-glucosamine 3-sulfotransferase activity (GO:0008467) 7 0 .00 - < 0.01 1.00E00 1.00E00 glycogenin glucosyltransferase activity (GO:0008466) 2 0 .00 - < 0.01 1.00E00 1.00E00 hydroxypyruvate reductase (NADH) activity (GO:0008465) 1 0 .00 - < 0.01 1.00E00 1.00E00 dTDP-glucose 4,6-dehydratase activity (GO:0008460) 1 0 .00 - < 0.01 1.00E00 1.00E00 cis-regulatory region sequence-specific DNA binding (GO:0000987) 1147 0 .33 - < 0.01 1.00E00 1.00E00 G-rich single-stranded DNA binding (GO:1990955) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981) 1329 0 .39 - < 0.01 1.00E00 1.00E00 L-cysteine-S-conjugate N-acetyltransferase activity (GO:0047198) 1 0 .00 - < 0.01 1.00E00 1.00E00 long-chain-alcohol O-fatty-acyltransferase activity (GO:0047196) 2 0 .00 - < 0.01 1.00E00 1.00E00 1-alkylglycerophosphocholine O-acetyltransferase activity (GO:0047192) 3 0 .00 - < 0.01 1.00E00 1.00E00 chondroitin 6-sulfotransferase activity (GO:0008459) 2 0 .00 - < 0.01 1.00E00 1.00E00 1-alkylglycerophosphocholine O-acyltransferase activity (GO:0047191) 1 0 .00 - < 0.01 1.00E00 1.00E00 carnitine O-octanoyltransferase activity (GO:0008458) 3 0 .00 - < 0.01 1.00E00 1.00E00 2-acylglycerophosphocholine O-acyltransferase activity (GO:0047190) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-N-acetylgalactosaminidase activity (GO:0008456) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity (GO:0008455) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity (GO:0008454) 3 0 .00 - < 0.01 1.00E00 1.00E00 alanine-glyoxylate transaminase activity (GO:0008453) 3 0 .00 - < 0.01 1.00E00 1.00E00 RNA ligase activity (GO:0008452) 2 0 .00 - < 0.01 1.00E00 1.00E00 heparanase activity (GO:0030305) 2 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin ligase inhibitor activity (GO:1990948) 11 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979) 20 0 .01 - < 0.01 1.00E00 1.00E00 RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978) 1120 0 .33 - < 0.01 1.00E00 1.00E00 RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977) 1337 0 .39 - < 0.01 1.00E00 1.00E00 transcription cis-regulatory region binding (GO:0000976) 1442 0 .42 - < 0.01 1.00E00 1.00E00 cerebroside-sulfatase activity (GO:0004098) 1 0 .00 - < 0.01 1.00E00 1.00E00 catalase activity (GO:0004096) 3 0 .00 - < 0.01 1.00E00 1.00E00 carnitine O-palmitoyltransferase activity (GO:0004095) 3 0 .00 - < 0.01 1.00E00 1.00E00 carnitine O-acetyltransferase activity (GO:0004092) 1 0 .00 - < 0.01 1.00E00 1.00E00 carbonyl reductase (NADPH) activity (GO:0004090) 10 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylneuraminate 9-O-acetyltransferase activity (GO:0047186) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-acylglycerophosphocholine O-acyltransferase activity (GO:0047184) 8 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylglucosamine-6-sulfatase activity (GO:0008449) 3 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylglucosamine-6-phosphate deacetylase activity (GO:0008448) 1 0 .00 - < 0.01 1.00E00 1.00E00 GDP-mannose 4,6-dehydratase activity (GO:0008446) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-aspartate oxidase activity (GO:0008445) 1 0 .00 - < 0.01 1.00E00 1.00E00 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity (GO:0008444) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphofructokinase activity (GO:0008443) 7 0 .00 - < 0.01 1.00E00 1.00E00 3-hydroxyisobutyrate dehydrogenase activity (GO:0008442) 1 0 .00 - < 0.01 1.00E00 1.00E00 3'(2'),5'-bisphosphate nucleotidase activity (GO:0008441) 2 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,4,5-trisphosphate 3-kinase activity (GO:0008440) 4 0 .00 - < 0.01 1.00E00 1.00E00 splicing factor binding (GO:1990935) 6 0 .00 - < 0.01 1.00E00 1.00E00 carbonate dehydratase activity (GO:0004089) 15 0 .00 - < 0.01 1.00E00 1.00E00 mRNA N6-methyladenosine dioxygenase activity (GO:1990931) 2 0 .00 - < 0.01 1.00E00 1.00E00 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (GO:0004088) 2 0 .00 - < 0.01 1.00E00 1.00E00 mRNA N1-methyladenosine dioxygenase activity (GO:1990930) 1 0 .00 - < 0.01 1.00E00 1.00E00 carbamoyl-phosphate synthase (ammonia) activity (GO:0004087) 2 0 .00 - < 0.01 1.00E00 1.00E00 branched-chain-amino-acid transaminase activity (GO:0004084) 2 0 .00 - < 0.01 1.00E00 1.00E00 U7 snRNA binding (GO:0071209) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone pre-mRNA DCP binding (GO:0071208) 4 0 .00 - < 0.01 1.00E00 1.00E00 bisphosphoglycerate mutase activity (GO:0004082) 4 0 .00 - < 0.01 1.00E00 1.00E00 histone pre-mRNA stem-loop binding (GO:0071207) 2 0 .00 - < 0.01 1.00E00 1.00E00 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (GO:0004081) 3 0 .00 - < 0.01 1.00E00 1.00E00 platelet-activating factor acetyltransferase activity (GO:0047179) 4 0 .00 - < 0.01 1.00E00 1.00E00 riboflavin binding (GO:1902444) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylcholine-retinol O-acyltransferase activity (GO:0047173) 1 0 .00 - < 0.01 1.00E00 1.00E00 serum response element binding (GO:0010736) 1 0 .00 - < 0.01 1.00E00 1.00E00 maleylacetoacetate isomerase activity (GO:0016034) 1 0 .00 - < 0.01 1.00E00 1.00E00 thyrotropin-releasing hormone activity (GO:0008437) 1 0 .00 - < 0.01 1.00E00 1.00E00 JUN kinase binding (GO:0008432) 11 0 .00 - < 0.01 1.00E00 1.00E00 vitamin E binding (GO:0008431) 4 0 .00 - < 0.01 1.00E00 1.00E00 selenium binding (GO:0008430) 9 0 .00 - < 0.01 1.00E00 1.00E00 biotin--[biotin carboxyl-carrier protein] ligase activity (GO:0004077) 1 0 .00 - < 0.01 1.00E00 1.00E00 biotin carboxylase activity (GO:0004075) 1 0 .00 - < 0.01 1.00E00 1.00E00 biliverdin reductase [NAD(P)+] activity (GO:0004074) 2 0 .00 - < 0.01 1.00E00 1.00E00 aspartate carbamoyltransferase activity (GO:0004070) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-alkenylglycerophosphoethanolamine O-acyltransferase activity (GO:0047166) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylethanolamine binding (GO:0008429) 17 0 .00 - < 0.01 1.00E00 1.00E00 ribonuclease inhibitor activity (GO:0008428) 3 0 .00 - < 0.01 1.00E00 1.00E00 calcium-dependent protein kinase inhibitor activity (GO:0008427) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein kinase C inhibitor activity (GO:0008426) 3 0 .00 - < 0.01 1.00E00 1.00E00 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (GO:0008425) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycoprotein 6-alpha-L-fucosyltransferase activity (GO:0008424) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-glucosidase activity (GO:0008422) 5 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat phosphatase activity (GO:0008420) 81 0 .02 - < 0.01 1.00E00 1.00E00 L-aspartate:2-oxoglutarate aminotransferase activity (GO:0004069) 3 0 .00 - < 0.01 1.00E00 1.00E00 aspartate 1-decarboxylase activity (GO:0004068) 2 0 .00 - < 0.01 1.00E00 1.00E00 asparaginase activity (GO:0004067) 2 0 .00 - < 0.01 1.00E00 1.00E00 asparagine synthase (glutamine-hydrolyzing) activity (GO:0004066) 2 0 .00 - < 0.01 1.00E00 1.00E00 arylsulfatase activity (GO:0004065) 14 0 .00 - < 0.01 1.00E00 1.00E00 arylesterase activity (GO:0004064) 6 0 .00 - < 0.01 1.00E00 1.00E00 aryldialkylphosphatase activity (GO:0004063) 2 0 .00 - < 0.01 1.00E00 1.00E00 aryl sulfotransferase activity (GO:0004062) 9 0 .00 - < 0.01 1.00E00 1.00E00 arylformamidase activity (GO:0004061) 1 0 .00 - < 0.01 1.00E00 1.00E00 arylamine N-acetyltransferase activity (GO:0004060) 3 0 .00 - < 0.01 1.00E00 1.00E00 plasmalogen synthase activity (GO:0047159) 2 0 .00 - < 0.01 1.00E00 1.00E00 peptidoglycan immune receptor activity (GO:0016019) 5 0 .00 - < 0.01 1.00E00 1.00E00 cyclosporin A binding (GO:0016018) 16 0 .00 - < 0.01 1.00E00 1.00E00 morphogen activity (GO:0016015) 7 0 .00 - < 0.01 1.00E00 1.00E00 RNA lariat debranching enzyme activity (GO:0008419) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-N-terminal asparagine amidohydrolase activity (GO:0008418) 2 0 .00 - < 0.01 1.00E00 1.00E00 betaine-homocysteine S-methyltransferase activity (GO:0047150) 1 0 .00 - < 0.01 1.00E00 1.00E00 fucosyltransferase activity (GO:0008417) 13 0 .00 - < 0.01 1.00E00 1.00E00 RIG-I binding (GO:0039552) 4 0 .00 - < 0.01 1.00E00 1.00E00 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity (GO:0008413) 2 0 .00 - < 0.01 1.00E00 1.00E00 4-hydroxybenzoate polyprenyltransferase activity (GO:0008412) 1 0 .00 - < 0.01 1.00E00 1.00E00 CoA-transferase activity (GO:0008410) 5 0 .00 - < 0.01 1.00E00 1.00E00 miRNA binding (GO:0035198) 33 0 .01 - < 0.01 1.00E00 1.00E00 siRNA binding (GO:0035197) 12 0 .00 - < 0.01 1.00E00 1.00E00 aralkylamine N-acetyltransferase activity (GO:0004059) 1 0 .00 - < 0.01 1.00E00 1.00E00 aromatic-L-amino-acid decarboxylase activity (GO:0004058) 1 0 .00 - < 0.01 1.00E00 1.00E00 arginyl-tRNA--protein transferase activity (GO:0004057) 1 0 .00 - < 0.01 1.00E00 1.00E00 argininosuccinate lyase activity (GO:0004056) 1 0 .00 - < 0.01 1.00E00 1.00E00 argininosuccinate synthase activity (GO:0004055) 1 0 .00 - < 0.01 1.00E00 1.00E00 arginase activity (GO:0004053) 3 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate 12(S)-lipoxygenase activity (GO:0004052) 4 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate 5-lipoxygenase activity (GO:0004051) 2 0 .00 - < 0.01 1.00E00 1.00E00 apyrase activity (GO:0004050) 3 0 .00 - < 0.01 1.00E00 1.00E00 diacylglycerol binding (GO:0019992) 14 0 .00 - < 0.01 1.00E00 1.00E00 2-acylglycerol-3-phosphate O-acyltransferase activity (GO:0047144) 9 0 .00 - < 0.01 1.00E00 1.00E00 phospholipase A2 activator activity (GO:0016005) 2 0 .00 - < 0.01 1.00E00 1.00E00 5'-3' exonuclease activity (GO:0008409) 18 0 .01 - < 0.01 1.00E00 1.00E00 phospholipase activator activity (GO:0016004) 20 0 .01 - < 0.01 1.00E00 1.00E00 3'-5' exonuclease activity (GO:0008408) 60 0 .02 - < 0.01 1.00E00 1.00E00 arachidonate 11,12-epoxygenase activity (GO:0008405) 2 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate 14,15-epoxygenase activity (GO:0008404) 3 0 .00 - < 0.01 1.00E00 1.00E00 25-hydroxycholecalciferol-24-hydroxylase activity (GO:0008403) 1 0 .00 - < 0.01 1.00E00 1.00E00 retinoic acid 4-hydroxylase activity (GO:0008401) 10 0 .00 - < 0.01 1.00E00 1.00E00 aminomethyltransferase activity (GO:0004047) 2 0 .00 - < 0.01 1.00E00 1.00E00 catalytic activity, acting on RNA (GO:0140098) 402 0 .12 - < 0.01 1.00E00 1.00E00 aminoacylase activity (GO:0004046) 5 0 .00 - < 0.01 1.00E00 1.00E00 catalytic activity, acting on DNA (GO:0140097) 251 0 .07 - < 0.01 1.00E00 1.00E00 aminoacyl-tRNA hydrolase activity (GO:0004045) 5 0 .00 - < 0.01 1.00E00 1.00E00 catalytic activity, acting on a protein (GO:0140096) 2311 0 .67 - < 0.01 1.00E00 1.00E00 amidophosphoribosyltransferase activity (GO:0004044) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-aminoadipate-semialdehyde dehydrogenase activity (GO:0004043) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-glutamate N-acetyltransferase activity (GO:0004042) 1 0 .00 - < 0.01 1.00E00 1.00E00 amidase activity (GO:0004040) 4 0 .00 - < 0.01 1.00E00 1.00E00 membrane curvature sensor activity (GO:0140090) 3 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-9 binding (GO:0019983) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-disulfide reductase [NAD(P)H] activity (GO:0047134) 9 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-6 binding (GO:0019981) 2 0 .00 - < 0.01 1.00E00 1.00E00 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity (GO:0047131) 1 0 .00 - < 0.01 1.00E00 1.00E00 saccharopine dehydrogenase (NADP+, L-lysine-forming) activity (GO:0047130) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3S10 kinase activity (GO:0035175) 244 0 .07 - < 0.01 1.00E00 1.00E00 allantoicase activity (GO:0004037) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone kinase activity (GO:0035173) 254 0 .07 - < 0.01 1.00E00 1.00E00 alkaline phosphatase activity (GO:0004035) 4 0 .00 - < 0.01 1.00E00 1.00E00 aldose 1-epimerase activity (GO:0004034) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-amino-acid N-acetyltransferase activity (GO:0140085) 8 0 .00 - < 0.01 1.00E00 1.00E00 aldo-keto reductase (NADPH) activity (GO:0004033) 36 1 .01 + 95.28 1.05E-02 1.00E00 ATP-dependent protein-DNA unloader activity (GO:0140083) 1 0 .00 - < 0.01 1.00E00 1.00E00 aldehyde oxidase activity (GO:0004031) 3 0 .00 - < 0.01 1.00E00 1.00E00 SUMO-ubiquitin ligase activity (GO:0140082) 1 0 .00 - < 0.01 1.00E00 1.00E00 aldehyde dehydrogenase [NAD(P)+] activity (GO:0004030) 18 0 .01 - < 0.01 1.00E00 1.00E00 glycosylated region protein binding (GO:0140081) 3 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-2 binding (GO:0019976) 3 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-17 binding (GO:0019975) 1 0 .00 - < 0.01 1.00E00 1.00E00 thiomorpholine-carboxylate dehydrogenase activity (GO:0047127) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-12 binding (GO:0019972) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-11 binding (GO:0019970) 4 0 .00 - < 0.01 1.00E00 1.00E00 dihydrosphingosine-1-phosphate phosphatase activity (GO:0070780) 2 0 .00 - < 0.01 1.00E00 1.00E00 aldehyde dehydrogenase (NAD+) activity (GO:0004029) 17 0 .00 - < 0.01 1.00E00 1.00E00 3-chloroallyl aldehyde dehydrogenase activity (GO:0004028) 5 0 .00 - < 0.01 1.00E00 1.00E00 alcohol sulfotransferase activity (GO:0004027) 4 0 .00 - < 0.01 1.00E00 1.00E00 class I DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0140078) 8 0 .00 - < 0.01 1.00E00 1.00E00 mRNA regulatory element binding translation repressor activity (GO:0000900) 17 0 .00 - < 0.01 1.00E00 1.00E00 alcohol dehydrogenase (NAD+) activity (GO:0004022) 23 0 .01 - < 0.01 1.00E00 1.00E00 interleukin-10 binding (GO:0019969) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-alanine:2-oxoglutarate aminotransferase activity (GO:0004021) 2 0 .00 - < 0.01 1.00E00 1.00E00 adenylylsulfate kinase activity (GO:0004020) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-1 binding (GO:0019966) 9 0 .00 - < 0.01 1.00E00 1.00E00 hydrogen peroxide channel activity (GO:0140070) 3 0 .00 - < 0.01 1.00E00 1.00E00 type II interferon binding (GO:0019964) 1 0 .00 - < 0.01 1.00E00 1.00E00 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity (GO:0047115) 3 0 .00 - < 0.01 1.00E00 1.00E00 type I interferon binding (GO:0019962) 2 0 .00 - < 0.01 1.00E00 1.00E00 interferon binding (GO:0019961) 3 0 .00 - < 0.01 1.00E00 1.00E00 C-X3-C chemokine binding (GO:0019960) 5 0 .00 - < 0.01 1.00E00 1.00E00 protein-N-terminal glutamine amidohydrolase activity (GO:0070773) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenylosuccinate synthase activity (GO:0004019) 2 0 .00 - < 0.01 1.00E00 1.00E00 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity (GO:0004018) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone butyryltransferase activity (GO:0140069) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenylate kinase activity (GO:0004017) 9 0 .00 - < 0.01 1.00E00 1.00E00 histone crotonyltransferase activity (GO:0140068) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenylate cyclase activity (GO:0004016) 11 0 .00 - < 0.01 1.00E00 1.00E00 adenosylmethionine decarboxylase activity (GO:0004014) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptide butyryltransferase activity (GO:0140065) 2 0 .00 - < 0.01 1.00E00 1.00E00 adenosylhomocysteinase activity (GO:0004013) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptide crotonyltransferase activity (GO:0140064) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-8 binding (GO:0019959) 3 0 .00 - < 0.01 1.00E00 1.00E00 C-X-C chemokine binding (GO:0019958) 6 0 .00 - < 0.01 1.00E00 1.00E00 C-C chemokine binding (GO:0019957) 24 0 .01 - < 0.01 1.00E00 1.00E00 chemokine binding (GO:0019956) 33 0 .01 - < 0.01 1.00E00 1.00E00 cytokine binding (GO:0019955) 143 0 .04 - < 0.01 1.00E00 1.00E00 4-trimethylammoniobutyraldehyde dehydrogenase activity (GO:0047105) 1 0 .00 - < 0.01 1.00E00 1.00E00 aminomuconate-semialdehyde dehydrogenase activity (GO:0047102) 1 0 .00 - < 0.01 1.00E00 1.00E00 branched-chain alpha-keto acid dehydrogenase activity (GO:0047101) 4 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type putrescine transporter activity (GO:0015594) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenosine kinase activity (GO:0004001) 1 0 .00 - < 0.01 1.00E00 1.00E00 SUMO activating enzyme activity (GO:0019948) 2 0 .00 - < 0.01 1.00E00 1.00E00 adenosine deaminase activity (GO:0004000) 12 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K16ac reader activity (GO:0140046) 2 0 .00 - < 0.01 1.00E00 1.00E00 serotonin receptor activity (GO:0099589) 19 0 .01 - < 0.01 1.00E00 1.00E00 C2H2 zinc finger domain binding (GO:0070742) 14 0 .00 - < 0.01 1.00E00 1.00E00 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration (GO:0099583) 2 0 .00 - < 0.01 1.00E00 1.00E00 mannose transmembrane transporter activity (GO:0015578) 1 0 .00 - < 0.01 1.00E00 1.00E00 tubulin-glutamic acid ligase activity (GO:0070740) 10 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol phosphate binding (GO:1901981) 185 0 .05 - < 0.01 1.00E00 1.00E00 ubiquitin-modified protein reader activity (GO:0140036) 19 0 .01 - < 0.01 1.00E00 1.00E00 ubiquitin-like protein reader activity (GO:0140035) 22 0 .01 - < 0.01 1.00E00 1.00E00 methylation-dependent protein binding (GO:0140034) 72 0 .02 - < 0.01 1.00E00 1.00E00 acetylation-dependent protein binding (GO:0140033) 22 0 .01 - < 0.01 1.00E00 1.00E00 glycosylation-dependent protein binding (GO:0140032) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphorylation-dependent protein binding (GO:0140031) 10 0 .00 - < 0.01 1.00E00 1.00E00 modification-dependent protein binding (GO:0140030) 169 0 .05 - < 0.01 1.00E00 1.00E00 protein-glutamic acid ligase activity (GO:0070739) 10 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential (GO:0099579) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein-glycine ligase activity, initiating (GO:0070736) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein-glycine ligase activity (GO:0070735) 3 0 .00 - < 0.01 1.00E00 1.00E00 AMPylase activity (GO:0070733) 2 0 .00 - < 0.01 1.00E00 1.00E00 efflux transmembrane transporter activity (GO:0015562) 16 0 .00 - < 0.01 1.00E00 1.00E00 cyclin-dependent protein kinase activating kinase regulator activity (GO:0019914) 1 0 .00 - < 0.01 1.00E00 1.00E00 cyclin-dependent protein kinase activating kinase activity (GO:0019912) 1 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of myelin sheath (GO:0019911) 11 0 .00 - < 0.01 1.00E00 1.00E00 L-leucine binding (GO:0070728) 7 0 .00 - < 0.01 1.00E00 1.00E00 calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration (GO:0099567) 1 0 .00 - < 0.01 1.00E00 1.00E00 C4-dicarboxylate transmembrane transporter activity (GO:0015556) 15 0 .00 - < 0.01 1.00E00 1.00E00 propionate transmembrane transporter activity (GO:0015552) 1 0 .00 - < 0.01 1.00E00 1.00E00 dIDP phosphatase activity (GO:0097383) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K14ac reader activity (GO:0140015) 2 0 .00 - < 0.01 1.00E00 1.00E00 D-aspartate transmembrane transporter activity (GO:0140010) 1 0 .00 - < 0.01 1.00E00 1.00E00 syntaxin binding (GO:0019905) 61 0 .02 - < 0.01 1.00E00 1.00E00 protein domain specific binding (GO:0019904) 635 0 .19 - < 0.01 1.00E00 1.00E00 protein phosphatase binding (GO:0019903) 145 0 .04 - < 0.01 1.00E00 1.00E00 phosphatase binding (GO:0019902) 192 0 .06 - < 0.01 1.00E00 1.00E00 protein kinase binding (GO:0019901) 702 0 .20 - < 0.01 1.00E00 1.00E00 kinase binding (GO:0019900) 781 0 .23 - < 0.01 1.00E00 1.00E00 poly-purine tract binding (GO:0070717) 31 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K18 deacetylase activity, NAD-dependent (GO:0097372) 5 0 .00 - < 0.01 1.00E00 1.00E00 MDM2/MDM4 family protein binding (GO:0097371) 12 0 .00 - < 0.01 1.00E00 1.00E00 histone H4 reader activity (GO:0140008) 5 0 .00 - < 0.01 1.00E00 1.00E00 histone H3 reader activity (GO:0140006) 9 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K20me2 reader activity (GO:0140005) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K4me3 reader activity (GO:0140002) 1 0 .00 - < 0.01 1.00E00 1.00E00 sterol desaturase activity (GO:0070704) 2 0 .00 - < 0.01 1.00E00 1.00E00 sialic acid:proton symporter activity (GO:0015538) 1 0 .00 - < 0.01 1.00E00 1.00E00 BMP receptor binding (GO:0070700) 13 0 .00 - < 0.01 1.00E00 1.00E00 carbohydrate derivative binding (GO:0097367) 2253 0 .66 - < 0.01 1.00E00 1.00E00 protein O-acetylglucosaminyltransferase activity (GO:0097363) 3 0 .00 - < 0.01 1.00E00 1.00E00 calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (GO:1905060) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration (GO:0099534) 2 0 .00 - < 0.01 1.00E00 1.00E00 hexose-phosphate:phosphate antiporter activity (GO:0015526) 3 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential (GO:0099530) 6 0 .00 - < 0.01 1.00E00 1.00E00 P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (GO:1905059) 1 0 .00 - < 0.01 1.00E00 1.00E00 P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration (GO:1905056) 1 0 .00 - < 0.01 1.00E00 1.00E00 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential (GO:0099529) 56 0 .02 - < 0.01 1.00E00 1.00E00 G protein-coupled neurotransmitter receptor activity (GO:0099528) 11 0 .00 - < 0.01 1.00E00 1.00E00 digestive hormone activity (GO:0046659) 1 0 .00 - < 0.01 1.00E00 1.00E00 cyclic-GMP-AMP hydrolase activity (GO:0106177) 1 0 .00 - < 0.01 1.00E00 1.00E00 galactose:proton symporter activity (GO:0015517) 1 0 .00 - < 0.01 1.00E00 1.00E00 ISG15 transferase activity (GO:0042296) 4 0 .00 - < 0.01 1.00E00 1.00E00 URM1 activating enzyme activity (GO:0042292) 1 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels (GO:0099511) 4 0 .00 - < 0.01 1.00E00 1.00E00 calcium ion binding involved in regulation of cytosolic calcium ion concentration (GO:0099510) 2 0 .00 - < 0.01 1.00E00 1.00E00 mRNA N-acetyltransferase activity (GO:0106162) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutamate:sodium symporter activity (GO:0015501) 5 0 .00 - < 0.01 1.00E00 1.00E00 MHC class II protein binding (GO:0042289) 6 0 .00 - < 0.01 1.00E00 1.00E00 MHC class I protein binding (GO:0042288) 19 0 .01 - < 0.01 1.00E00 1.00E00 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (GO:1905030) 4 0 .00 - < 0.01 1.00E00 1.00E00 MHC protein binding (GO:0042287) 40 0 .01 - < 0.01 1.00E00 1.00E00 xylosyltransferase activity (GO:0042285) 11 0 .00 - < 0.01 1.00E00 1.00E00 sphingolipid delta-4 desaturase activity (GO:0042284) 2 0 .00 - < 0.01 1.00E00 1.00E00 dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity (GO:0042283) 1 0 .00 - < 0.01 1.00E00 1.00E00 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity (GO:0042281) 1 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508) 11 0 .00 - < 0.01 1.00E00 1.00E00 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) 16 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-arginine 3-dioxygenase activity (GO:0106157) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-lysine 4-dioxygenase activity (GO:0106156) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-lysine 3-dioxygenase activity (GO:0106155) 1 0 .00 - < 0.01 1.00E00 1.00E00 7SK snRNA binding (GO:0097322) 9 0 .00 - < 0.01 1.00E00 1.00E00 peptide binding (GO:0042277) 245 0 .07 - < 0.01 1.00E00 1.00E00 caspase binding (GO:0089720) 13 0 .00 - < 0.01 1.00E00 1.00E00 sphingolipid binding (GO:0046625) 28 0 .01 - < 0.01 1.00E00 1.00E00 sphingolipid transporter activity (GO:0046624) 19 0 .01 - < 0.01 1.00E00 1.00E00 sphingolipid floppase activity (GO:0046623) 3 0 .00 - < 0.01 1.00E00 1.00E00 P-TEFb complex binding (GO:0106140) 4 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity (GO:0089715) 1 0 .00 - < 0.01 1.00E00 1.00E00 Sec61 translocon complex binding (GO:0106138) 1 0 .00 - < 0.01 1.00E00 1.00E00 IkappaB kinase complex binding (GO:0106137) 2 0 .00 - < 0.01 1.00E00 1.00E00 purine phosphoribosyltransferase activity (GO:0106130) 2 0 .00 - < 0.01 1.00E00 1.00E00 receptor signaling protein tyrosine kinase activator activity (GO:0030298) 5 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane receptor protein tyrosine kinase activator activity (GO:0030297) 18 0 .01 - < 0.01 1.00E00 1.00E00 protein tyrosine kinase activator activity (GO:0030296) 34 0 .01 - < 0.01 1.00E00 1.00E00 protein kinase activator activity (GO:0030295) 143 0 .04 - < 0.01 1.00E00 1.00E00 receptor signaling protein tyrosine kinase inhibitor activity (GO:0030294) 1 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane receptor protein tyrosine kinase inhibitor activity (GO:0030293) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein tyrosine kinase inhibitor activity (GO:0030292) 9 0 .00 - < 0.01 1.00E00 1.00E00 protein serine/threonine kinase inhibitor activity (GO:0030291) 49 0 .01 - < 0.01 1.00E00 1.00E00 sphingolipid activator protein activity (GO:0030290) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K4me/H3K4me2/H3K4me3 demethylase activity (GO:0034647) 5 0 .00 - < 0.01 1.00E00 1.00E00 nuclear estrogen receptor activity (GO:0030284) 4 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of skin epidermis (GO:0030280) 37 0 .01 - < 0.01 1.00E00 1.00E00 glutathione transmembrane transporter activity (GO:0034634) 7 0 .00 - < 0.01 1.00E00 1.00E00 retinol transmembrane transporter activity (GO:0034632) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K9 demethylase activity (GO:0032454) 14 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K4 demethylase activity (GO:0032453) 8 0 .00 - < 0.01 1.00E00 1.00E00 histone demethylase activity (GO:0032452) 30 0 .01 - < 0.01 1.00E00 1.00E00 demethylase activity (GO:0032451) 40 0 .01 - < 0.01 1.00E00 1.00E00 Ala-tRNA(Thr) hydrolase activity (GO:0106105) 1 0 .00 - < 0.01 1.00E00 1.00E00 clathrin binding (GO:0030276) 46 0 .01 - < 0.01 1.00E00 1.00E00 LRR domain binding (GO:0030275) 16 0 .00 - < 0.01 1.00E00 1.00E00 LIM domain binding (GO:0030274) 6 0 .00 - < 0.01 1.00E00 1.00E00 melanin-concentrating hormone receptor activity (GO:0030273) 1 0 .00 - < 0.01 1.00E00 1.00E00 5-formyltetrahydrofolate cyclo-ligase activity (GO:0030272) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA hairpin binding (GO:0032448) 1 0 .00 - < 0.01 1.00E00 1.00E00 glyoxylate reductase (NADPH) activity (GO:0030267) 1 0 .00 - < 0.01 1.00E00 1.00E00 2-alkenal reductase [NAD(P)+] activity (GO:0032440) 1 0 .00 - < 0.01 1.00E00 1.00E00 arginine binding (GO:0034618) 8 0 .00 - < 0.01 1.00E00 1.00E00 tetrahydrobiopterin binding (GO:0034617) 4 0 .00 - < 0.01 1.00E00 1.00E00 oligoribonucleotidase activity (GO:0034611) 1 0 .00 - < 0.01 1.00E00 1.00E00 guanylate cyclase inhibitor activity (GO:0030251) 1 0 .00 - < 0.01 1.00E00 1.00E00 guanylate cyclase activator activity (GO:0030250) 7 0 .00 - < 0.01 1.00E00 1.00E00 netrin receptor binding (GO:1990890) 2 0 .00 - < 0.01 1.00E00 1.00E00 RNA cap trimethylguanosine synthase activity (GO:0071164) 1 0 .00 - < 0.01 1.00E00 1.00E00 pyruvate dehydrogenase (NAD+) activity (GO:0034604) 6 0 .00 - < 0.01 1.00E00 1.00E00 pyruvate dehydrogenase [NAD(P)+] activity (GO:0034603) 6 0 .00 - < 0.01 1.00E00 1.00E00 oxoglutarate dehydrogenase (NAD+) activity (GO:0034602) 1 0 .00 - < 0.01 1.00E00 1.00E00 acetyltransferase activator activity (GO:0010698) 10 0 .00 - < 0.01 1.00E00 1.00E00 beta-N-acetylgalactosaminidase activity (GO:0032428) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxoglutarate dehydrogenase [NAD(P)+] activity (GO:0034601) 1 0 .00 - < 0.01 1.00E00 1.00E00 GBD domain binding (GO:0032427) 2 0 .00 - < 0.01 1.00E00 1.00E00 sterol 14-demethylase activity (GO:0008398) 1 0 .00 - < 0.01 1.00E00 1.00E00 sterol 12-alpha-hydroxylase activity (GO:0008397) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxysterol 7-alpha-hydroxylase activity (GO:0008396) 2 0 .00 - < 0.01 1.00E00 1.00E00 guanylate cyclase regulator activity (GO:0030249) 8 0 .00 - < 0.01 1.00E00 1.00E00 purine-rich negative regulatory element binding (GO:0032422) 4 0 .00 - < 0.01 1.00E00 1.00E00 steroid hydroxylase activity (GO:0008395) 27 1 .01 + > 100 7.85E-03 1.00E00 polysaccharide binding (GO:0030247) 26 0 .01 - < 0.01 1.00E00 1.00E00 carbohydrate binding (GO:0030246) 279 0 .08 - < 0.01 1.00E00 1.00E00 H4K20me3 modified histone binding (GO:1990889) 2 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate epoxygenase activity (GO:0008392) 15 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate monooxygenase activity (GO:0008391) 17 0 .00 - < 0.01 1.00E00 1.00E00 testosterone 16-alpha-hydroxylase activity (GO:0008390) 1 0 .00 - < 0.01 1.00E00 1.00E00 18S rRNA cytidine N-acetyltransferase activity (GO:1990883) 1 0 .00 - < 0.01 1.00E00 1.00E00 coumarin 7-hydroxylase activity (GO:0008389) 2 0 .00 - < 0.01 1.00E00 1.00E00 steroid 7-alpha-hydroxylase activity (GO:0008387) 3 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol monooxygenase (side-chain-cleaving) activity (GO:0008386) 1 0 .00 - < 0.01 1.00E00 1.00E00 IkappaB kinase activity (GO:0008384) 3 0 .00 - < 0.01 1.00E00 1.00E00 nitric-oxide synthase regulator activity (GO:0030235) 7 0 .00 - < 0.01 1.00E00 1.00E00 mechanosensitive monoatomic ion channel activity (GO:0008381) 19 0 .01 - < 0.01 1.00E00 1.00E00 enzyme regulator activity (GO:0030234) 1372 0 .40 - < 0.01 1.00E00 1.00E00 deoxynucleotide transmembrane transporter activity (GO:0030233) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AK5 acetyltransferase activity (GO:0043999) 20 0 .01 - < 0.01 1.00E00 1.00E00 histone H2A acetyltransferase activity (GO:0043998) 22 0 .01 - < 0.01 1.00E00 1.00E00 histone H4K12 acetyltransferase activity (GO:0043997) 28 0 .01 - < 0.01 1.00E00 1.00E00 histone H4K8 acetyltransferase activity (GO:0043996) 28 0 .01 - < 0.01 1.00E00 1.00E00 histone H4K5 acetyltransferase activity (GO:0043995) 28 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K23 acetyltransferase activity (GO:0043994) 20 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K18 acetyltransferase activity (GO:0043993) 20 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K9 acetyltransferase activity (GO:0043992) 20 0 .01 - < 0.01 1.00E00 1.00E00 ceramide 1-phosphate transfer activity (GO:1902388) 7 0 .00 - < 0.01 1.00E00 1.00E00 ceramide 1-phosphate binding (GO:1902387) 7 0 .00 - < 0.01 1.00E00 1.00E00 MutSbeta complex binding (GO:0032408) 2 0 .00 - < 0.01 1.00E00 1.00E00 MutSalpha complex binding (GO:0032407) 7 0 .00 - < 0.01 1.00E00 1.00E00 MutLbeta complex binding (GO:0032406) 2 0 .00 - < 0.01 1.00E00 1.00E00 thioredoxin peroxidase activity (GO:0008379) 6 0 .00 - < 0.01 1.00E00 1.00E00 MutLalpha complex binding (GO:0032405) 6 0 .00 - < 0.01 1.00E00 1.00E00 galactosyltransferase activity (GO:0008378) 31 0 .01 - < 0.01 1.00E00 1.00E00 mismatch repair complex binding (GO:0032404) 11 0 .00 - < 0.01 1.00E00 1.00E00 acetylgalactosaminyltransferase activity (GO:0008376) 34 0 .01 - < 0.01 1.00E00 1.00E00 very-low-density lipoprotein particle receptor activity (GO:0030229) 4 0 .00 - < 0.01 1.00E00 1.00E00 acetylglucosaminyltransferase activity (GO:0008375) 43 0 .01 - < 0.01 1.00E00 1.00E00 lipoprotein particle receptor activity (GO:0030228) 18 0 .01 - < 0.01 1.00E00 1.00E00 O-acyltransferase activity (GO:0008374) 55 0 .02 - < 0.01 1.00E00 1.00E00 sialyltransferase activity (GO:0008373) 21 0 .01 - < 0.01 1.00E00 1.00E00 apolipoprotein receptor activity (GO:0030226) 3 0 .00 - < 0.01 1.00E00 1.00E00 chemoattractant activity involved in axon guidance (GO:1902379) 2 0 .00 - < 0.01 1.00E00 1.00E00 semaphorin receptor binding (GO:0030215) 24 0 .01 - < 0.01 1.00E00 1.00E00 methionyl-initiator methionine tRNA binding (GO:1990856) 1 0 .00 - < 0.01 1.00E00 1.00E00 5'-deoxyribose-5-phosphate lyase activity (GO:0051575) 8 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat kinase activity (GO:0008353) 10 0 .00 - < 0.01 1.00E00 1.00E00 promoter-specific chromatin binding (GO:1990841) 71 0 .02 - < 0.01 1.00E00 1.00E00 ketosteroid monooxygenase activity (GO:0047086) 5 0 .00 - < 0.01 1.00E00 1.00E00 MAP kinase kinase kinase kinase activity (GO:0008349) 6 0 .00 - < 0.01 1.00E00 1.00E00 poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends (GO:1990838) 1 0 .00 - < 0.01 1.00E00 1.00E00 sequence-specific double-stranded DNA binding (GO:1990837) 1514 0 .44 - < 0.01 1.00E00 1.00E00 3-hydroxypropionyl-CoA dehydratase activity (GO:0043956) 1 0 .00 - < 0.01 1.00E00 1.00E00 threonine racemase activity (GO:0018114) 1 0 .00 - < 0.01 1.00E00 1.00E00 gamma-butyrobetaine dioxygenase activity (GO:0008336) 1 0 .00 - < 0.01 1.00E00 1.00E00 C-rich single-stranded DNA binding (GO:1990829) 1 0 .00 - < 0.01 1.00E00 1.00E00 low voltage-gated calcium channel activity (GO:0008332) 2 0 .00 - < 0.01 1.00E00 1.00E00 high voltage-gated calcium channel activity (GO:0008331) 14 0 .00 - < 0.01 1.00E00 1.00E00 thioesterase binding (GO:0031996) 10 0 .00 - < 0.01 1.00E00 1.00E00 protein tyrosine/threonine phosphatase activity (GO:0008330) 8 0 .00 - < 0.01 1.00E00 1.00E00 insulin-like growth factor II binding (GO:0031995) 8 0 .00 - < 0.01 1.00E00 1.00E00 insulin-like growth factor I binding (GO:0031994) 13 0 .00 - < 0.01 1.00E00 1.00E00 sequence-specific mRNA binding (GO:1990825) 13 0 .00 - < 0.01 1.00E00 1.00E00 metal cluster binding (GO:0051540) 76 0 .02 - < 0.01 1.00E00 1.00E00 phospholipid-hydroperoxide glutathione peroxidase activity (GO:0047066) 4 0 .00 - < 0.01 1.00E00 1.00E00 methyl-CpG binding (GO:0008327) 31 0 .01 - < 0.01 1.00E00 1.00E00 monoatomic cation transmembrane transporter activity (GO:0008324) 649 0 .19 - < 0.01 1.00E00 1.00E00 poly(A) RNA polymerase activity (GO:1990817) 12 0 .00 - < 0.01 1.00E00 1.00E00 protein transmembrane transporter activity (GO:0008320) 27 0 .01 - < 0.01 1.00E00 1.00E00 DNA/DNA annealing activity (GO:1990814) 8 0 .00 - < 0.01 1.00E00 1.00E00 4 iron, 4 sulfur cluster binding (GO:0051539) 45 0 .01 - < 0.01 1.00E00 1.00E00 3 iron, 4 sulfur cluster binding (GO:0051538) 3 0 .00 - < 0.01 1.00E00 1.00E00 2 iron, 2 sulfur cluster binding (GO:0051537) 27 0 .01 - < 0.01 1.00E00 1.00E00 iron-sulfur cluster binding (GO:0051536) 75 0 .02 - < 0.01 1.00E00 1.00E00 vitamin-K-epoxide reductase (warfarin-insensitive) activity (GO:0047058) 1 0 .00 - < 0.01 1.00E00 1.00E00 vitamin-K-epoxide reductase (warfarin-sensitive) activity (GO:0047057) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein prenyltransferase activity (GO:0008318) 7 0 .00 - < 0.01 1.00E00 1.00E00 Unclassified (UNCLASSIFIED) 2300 0 .67 - < 0.01 1.00E00 1.00E00 7S RNA binding (GO:0008312) 7 0 .00 - < 0.01 1.00E00 1.00E00 double-stranded DNA 3'-5' DNA exonuclease activity (GO:0008311) 6 0 .00 - < 0.01 1.00E00 1.00E00 single-stranded DNA 3'-5' DNA exonuclease activity (GO:0008310) 7 0 .00 - < 0.01 1.00E00 1.00E00 inositol hexakisphosphate 5-kinase activity (GO:0000832) 5 0 .00 - < 0.01 1.00E00 1.00E00 inositol hexakisphosphate 6-kinase activity (GO:0000831) 1 0 .00 - < 0.01 1.00E00 1.00E00 NFAT protein binding (GO:0051525) 6 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol binding (GO:0035091) 283 0 .08 - < 0.01 1.00E00 1.00E00 enzyme binding (GO:0019899) 2090 0 .61 - < 0.01 1.00E00 1.00E00 suramin binding (GO:0043924) 2 0 .00 - < 0.01 1.00E00 1.00E00 kinesin binding (GO:0019894) 43 0 .01 - < 0.01 1.00E00 1.00E00 androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity (GO:0047044) 9 0 .00 - < 0.01 1.00E00 1.00E00 androsterone dehydrogenase (B-specific) activity (GO:0047042) 1 0 .00 - < 0.01 1.00E00 1.00E00 double-stranded DNA exodeoxyribonuclease activity (GO:0008309) 8 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated monoatomic anion channel activity (GO:0008308) 17 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of muscle (GO:0008307) 42 0 .01 - < 0.01 1.00E00 1.00E00 diphosphoinositol pentakisphosphate kinase activity (GO:0000829) 5 0 .00 - < 0.01 1.00E00 1.00E00 DNA binding, bending (GO:0008301) 20 0 .01 - < 0.01 1.00E00 1.00E00 inositol hexakisphosphate kinase activity (GO:0000828) 8 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,3,4,5,6-pentakisphosphate kinase activity (GO:0000827) 5 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,3,4,5-tetrakisphosphate 6-kinase activity (GO:0000825) 2 0 .00 - < 0.01 1.00E00 1.00E00 nuclear mineralocorticoid receptor binding (GO:0031962) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,4,5,6-tetrakisphosphate 3-kinase activity (GO:0000824) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,4,5-trisphosphate 6-kinase activity (GO:0000823) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol hexakisphosphate binding (GO:0000822) 4 0 .00 - < 0.01 1.00E00 1.00E00 DNA-7-methylguanine glycosylase activity (GO:0043916) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-seryl-tRNA(Sec) kinase activity (GO:0043915) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein phosphatase regulator activity (GO:0019888) 109 0 .03 - < 0.01 1.00E00 1.00E00 protein kinase regulator activity (GO:0019887) 262 0 .08 - < 0.01 1.00E00 1.00E00 type II activin receptor binding (GO:0070699) 2 0 .00 - < 0.01 1.00E00 1.00E00 type I activin receptor binding (GO:0070698) 2 0 .00 - < 0.01 1.00E00 1.00E00 activin receptor binding (GO:0070697) 11 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane receptor protein serine/threonine kinase binding (GO:0070696) 24 0 .01 - < 0.01 1.00E00 1.00E00 5-hydroxymethyl-dUMP N-hydrolase activity (GO:0070694) 2 0 .00 - < 0.01 1.00E00 1.00E00 very long-chain fatty acid-CoA ligase activity (GO:0031957) 10 0 .00 - < 0.01 1.00E00 1.00E00 medium-chain fatty acid-CoA ligase activity (GO:0031956) 10 0 .00 - < 0.01 1.00E00 1.00E00 short-chain fatty acid-CoA ligase activity (GO:0031955) 4 0 .00 - < 0.01 1.00E00 1.00E00 diacylglycerol diphosphate phosphatase activity (GO:0000810) 3 0 .00 - < 0.01 1.00E00 1.00E00 D-tyrosyl-tRNA(Tyr) deacylase activity (GO:0051500) 2 0 .00 - < 0.01 1.00E00 1.00E00 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity (GO:0047024) 6 0 .00 - < 0.01 1.00E00 1.00E00 sodium channel inhibitor activity (GO:0019871) 8 0 .00 - < 0.01 1.00E00 1.00E00 androsterone dehydrogenase [NAD(P)+] activity (GO:0047023) 8 0 .00 - < 0.01 1.00E00 1.00E00 potassium channel inhibitor activity (GO:0019870) 7 0 .00 - < 0.01 1.00E00 1.00E00 7-beta-hydroxysteroid dehydrogenase (NADP+) activity (GO:0047022) 1 0 .00 - < 0.01 1.00E00 1.00E00 15-hydroxyprostaglandin dehydrogenase (NADP+) activity (GO:0047021) 1 0 .00 - < 0.01 1.00E00 1.00E00 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity (GO:0047020) 2 0 .00 - < 0.01 1.00E00 1.00E00 methylated histone binding (GO:0035064) 70 0 .02 - < 0.01 1.00E00 1.00E00 chloride channel inhibitor activity (GO:0019869) 7 0 .00 - < 0.01 1.00E00 1.00E00 immunoglobulin binding (GO:0019865) 26 0 .01 - < 0.01 1.00E00 1.00E00 prostaglandin F synthase activity (GO:0047017) 2 0 .00 - < 0.01 1.00E00 1.00E00 IgG binding (GO:0019864) 11 0 .00 - < 0.01 1.00E00 1.00E00 cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity (GO:0047016) 1 0 .00 - < 0.01 1.00E00 1.00E00 IgE binding (GO:0019863) 5 0 .00 - < 0.01 1.00E00 1.00E00 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity (GO:0047015) 1 0 .00 - < 0.01 1.00E00 1.00E00 IgA binding (GO:0019862) 3 0 .00 - < 0.01 1.00E00 1.00E00 inositol 1,4,5 trisphosphate binding (GO:0070679) 12 0 .00 - < 0.01 1.00E00 1.00E00 preprotein binding (GO:0070678) 1 0 .00 - < 0.01 1.00E00 1.00E00 hypoxanthine oxidase activity (GO:0070675) 1 0 .00 - < 0.01 1.00E00 1.00E00 hypoxanthine dehydrogenase activity (GO:0070674) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcium channel inhibitor activity (GO:0019855) 13 0 .00 - < 0.01 1.00E00 1.00E00 formate transmembrane transporter activity (GO:0015499) 1 0 .00 - < 0.01 1.00E00 1.00E00 pantothenate:sodium symporter activity (GO:0015498) 1 0 .00 - < 0.01 1.00E00 1.00E00 gamma-aminobutyric acid:proton symporter activity (GO:0015495) 1 0 .00 - < 0.01 1.00E00 1.00E00 rRNA binding (GO:0019843) 65 0 .02 - < 0.01 1.00E00 1.00E00 vitamin binding (GO:0019842) 148 0 .04 - < 0.01 1.00E00 1.00E00 retinol binding (GO:0019841) 16 0 .00 - < 0.01 1.00E00 1.00E00 isoprenoid binding (GO:0019840) 39 0 .01 - < 0.01 1.00E00 1.00E00 high-density lipoprotein particle receptor binding (GO:0070653) 3 0 .00 - < 0.01 1.00E00 1.00E00 putrescine transmembrane transporter activity (GO:0015489) 4 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol binding (GO:0015485) 55 0 .02 - < 0.01 1.00E00 1.00E00 histone acetyltransferase binding (GO:0035035) 24 0 .01 - < 0.01 1.00E00 1.00E00 histone acetyltransferase regulator activity (GO:0035034) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone deacetylase regulator activity (GO:0035033) 7 0 .00 - < 0.01 1.00E00 1.00E00 growth factor binding (GO:0019838) 136 0 .04 - < 0.01 1.00E00 1.00E00 phospholipase A2 inhibitor activity (GO:0019834) 4 0 .00 - < 0.01 1.00E00 1.00E00 vitamin D response element binding (GO:0070644) 3 0 .00 - < 0.01 1.00E00 1.00E00 ATPase-coupled monoatomic cation transmembrane transporter activity (GO:0019829) 54 0 .02 - < 0.01 1.00E00 1.00E00 aspartic-type endopeptidase inhibitor activity (GO:0019828) 6 0 .00 - < 0.01 1.00E00 1.00E00 oxygen sensor activity (GO:0019826) 5 0 .00 - < 0.01 1.00E00 1.00E00 oxygen binding (GO:0019825) 32 1 .01 + > 100 9.29E-03 1.00E00 G-protein activated inward rectifier potassium channel activity (GO:0015467) 4 0 .00 - < 0.01 1.00E00 1.00E00 acetylcholine receptor activity (GO:0015464) 20 0 .01 - < 0.01 1.00E00 1.00E00 phosphatidylinositol 3-kinase regulator activity (GO:0035014) 12 0 .00 - < 0.01 1.00E00 1.00E00 cocaine binding (GO:0019811) 1 0 .00 - < 0.01 1.00E00 1.00E00 proteasome binding (GO:0070628) 18 0 .01 - < 0.01 1.00E00 1.00E00 putrescine binding (GO:0019810) 1 0 .00 - < 0.01 1.00E00 1.00E00 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity (GO:0070626) 1 0 .00 - < 0.01 1.00E00 1.00E00 potassium channel regulator activity (GO:0015459) 58 0 .02 - < 0.01 1.00E00 1.00E00 polyamine oxidase activity (GO:0046592) 2 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreduction-driven active transmembrane transporter activity (GO:0015453) 66 0 .02 - < 0.01 1.00E00 1.00E00 protein-transporting ATPase activity (GO:0015450) 1 0 .00 - < 0.01 1.00E00 1.00E00 1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005) 7 0 .00 - < 0.01 1.00E00 1.00E00 spermidine binding (GO:0019809) 2 0 .00 - < 0.01 1.00E00 1.00E00 polyamine binding (GO:0019808) 3 0 .00 - < 0.01 1.00E00 1.00E00 aspartoacylase activity (GO:0019807) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcium-induced calcium release activity (GO:0048763) 5 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AR3 methyltransferase activity (GO:0070612) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3R2 methyltransferase activity (GO:0070611) 8 0 .00 - < 0.01 1.00E00 1.00E00 monoatomic cation efflux transmembrane transporter activity (GO:0046583) 2 0 .00 - < 0.01 1.00E00 1.00E00 P-type magnesium transporter activity (GO:0015444) 1 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type peptide transporter activity (GO:0015440) 3 0 .00 - < 0.01 1.00E00 1.00E00 long-chain-alcohol oxidase activity (GO:0046577) 1 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type heme transporter activity (GO:0015439) 1 0 .00 - < 0.01 1.00E00 1.00E00 all-trans-decaprenyl-diphosphate synthase activity (GO:0097269) 2 0 .00 - < 0.01 1.00E00 1.00E00 lactonohydrolase activity (GO:0046573) 3 0 .00 - < 0.01 1.00E00 1.00E00 MHC class Ib protein binding, via antigen binding groove (GO:0023030) 2 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type peptide antigen transporter activity (GO:0015433) 2 0 .00 - < 0.01 1.00E00 1.00E00 methylthioribulose 1-phosphate dehydratase activity (GO:0046570) 1 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type bile acid transporter activity (GO:0015432) 4 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type glutathione S-conjugate transporter activity (GO:0015431) 8 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-like protein conjugating enzyme binding (GO:0044390) 36 0 .01 - < 0.01 1.00E00 1.00E00 alcohol-forming long-chain fatty acyl-CoA reductase activity (GO:0102965) 2 0 .00 - < 0.01 1.00E00 1.00E00 MHC class Ib protein binding (GO:0023029) 8 0 .00 - < 0.01 1.00E00 1.00E00 MHC class II protein complex binding (GO:0023026) 27 0 .01 - < 0.01 1.00E00 1.00E00 MHC class Ib protein complex binding (GO:0023025) 4 0 .00 - < 0.01 1.00E00 1.00E00 MHC class I protein complex binding (GO:0023024) 7 0 .00 - < 0.01 1.00E00 1.00E00 MHC protein complex binding (GO:0023023) 37 0 .01 - < 0.01 1.00E00 1.00E00 20-aldehyde-leukotriene B4 20-monooxygenase activity (GO:0097259) 2 0 .00 - < 0.01 1.00E00 1.00E00 20-hydroxy-leukotriene B4 omega oxidase activity (GO:0097258) 2 0 .00 - < 0.01 1.00E00 1.00E00 leukotriene B4 12-hydroxy dehydrogenase activity (GO:0097257) 1 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-like protein ligase binding (GO:0044389) 321 0 .09 - < 0.01 1.00E00 1.00E00 small protein activating enzyme binding (GO:0044388) 5 0 .00 - < 0.01 1.00E00 1.00E00 GATOR1 complex binding (GO:0106080) 1 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type oligopeptide transporter activity (GO:0015421) 1 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type vitamin B12 transporter activity (GO:0015420) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone succinyltransferase activity (GO:0106078) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-L-arabinofuranosidase activity (GO:0046556) 2 0 .00 - < 0.01 1.00E00 1.00E00 peptide N-succinyltransferase activity (GO:0106075) 1 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type polyamine transporter activity (GO:0015417) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-malate dehydrogenase (NADP+) activity (GO:0046554) 1 0 .00 - < 0.01 1.00E00 1.00E00 dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity (GO:0106073) 2 0 .00 - < 0.01 1.00E00 1.00E00 non-sequence-specific DNA binding, bending (GO:0044378) 2 0 .00 - < 0.01 1.00E00 1.00E00 flavonoid binding (GO:0097243) 2 0 .00 - < 0.01 1.00E00 1.00E00 NuRD complex binding (GO:0120325) 3 0 .00 - < 0.01 1.00E00 1.00E00 ABC-type manganese transporter activity (GO:0015410) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity (GO:0034597) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol phosphate 4-phosphatase activity (GO:0034596) 10 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol phosphate 5-phosphatase activity (GO:0034595) 14 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol trisphosphate phosphatase activity (GO:0034594) 11 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol bisphosphate phosphatase activity (GO:0034593) 27 0 .01 - < 0.01 1.00E00 1.00E00 L-hydroxyproline transmembrane transporter activity (GO:0034590) 1 0 .00 - < 0.01 1.00E00 1.00E00 long-chain fatty acid omega-1 hydroxylase activity (GO:0120319) 4 0 .00 - < 0.01 1.00E00 1.00E00 piRNA binding (GO:0034584) 7 0 .00 - < 0.01 1.00E00 1.00E00 histamine N-methyltransferase activity (GO:0046539) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA 2'-O-methyltransferase activity (GO:0106050) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone lactyltransferase (CoA-dependent) activity (GO:0120301) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptide lactyltransferase (CoA-dependent) activity (GO:0120300) 3 0 .00 - < 0.01 1.00E00 1.00E00 lysophosphatidic acid acyltransferase activity (GO:0042171) 23 0 .01 - < 0.01 1.00E00 1.00E00 HECT domain binding (GO:0032399) 1 0 .00 - < 0.01 1.00E00 1.00E00 activating MHC class I receptor activity (GO:0032397) 2 0 .00 - < 0.01 1.00E00 1.00E00 inhibitory MHC class I receptor activity (GO:0032396) 13 0 .00 - < 0.01 1.00E00 1.00E00 MHC class II receptor activity (GO:0032395) 10 0 .00 - < 0.01 1.00E00 1.00E00 MHC class Ib receptor activity (GO:0032394) 7 0 .00 - < 0.01 1.00E00 1.00E00 MHC class I receptor activity (GO:0032393) 18 0 .01 - < 0.01 1.00E00 1.00E00 glucosyltransferase activity (GO:0046527) 19 0 .01 - < 0.01 1.00E00 1.00E00 D-xylulose reductase activity (GO:0046526) 1 0 .00 - < 0.01 1.00E00 1.00E00 xylosylprotein 4-beta-galactosyltransferase activity (GO:0046525) 1 0 .00 - < 0.01 1.00E00 1.00E00 S-methyl-5-thioribose-1-phosphate isomerase activity (GO:0046523) 1 0 .00 - < 0.01 1.00E00 1.00E00 SH2 domain binding (GO:0042169) 41 0 .01 - < 0.01 1.00E00 1.00E00 acetylcholine binding (GO:0042166) 10 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-12 alpha subunit binding (GO:0042164) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-12 beta subunit binding (GO:0042163) 1 0 .00 - < 0.01 1.00E00 1.00E00 telomeric DNA binding (GO:0042162) 38 0 .01 - < 0.01 1.00E00 1.00E00 tRNA pseudouridine synthase activity (GO:0106029) 8 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on carbon-sulfur bonds (GO:0046508) 1 0 .00 - < 0.01 1.00E00 1.00E00 extracellular matrix constituent, lubricant activity (GO:0030197) 4 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane transporter binding (GO:0044325) 138 0 .04 - < 0.01 1.00E00 1.00E00 retinoic acid-responsive element binding (GO:0044323) 6 0 .00 - < 0.01 1.00E00 1.00E00 fumarylpyruvate hydrolase activity (GO:0034545) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228) 433 0 .13 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-4,5-bisphosphate phosphatase activity (GO:0106019) 12 0 .00 - < 0.01 1.00E00 1.00E00 DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227) 268 0 .08 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,5-bisphosphate phosphatase activity (GO:0106018) 16 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,4-bisphosphate phosphatase activity (GO:0106017) 4 0 .00 - < 0.01 1.00E00 1.00E00 transcription coactivator binding (GO:0001223) 46 0 .01 - < 0.01 1.00E00 1.00E00 transcription corepressor binding (GO:0001222) 49 0 .01 - < 0.01 1.00E00 1.00E00 transcription coregulator binding (GO:0001221) 117 0 .03 - < 0.01 1.00E00 1.00E00 nitric oxide transmembrane transporter activity (GO:0030184) 1 0 .00 - < 0.01 1.00E00 1.00E00 rRNA primary transcript binding (GO:0042134) 3 0 .00 - < 0.01 1.00E00 1.00E00 fructose 1,6-bisphosphate 1-phosphatase activity (GO:0042132) 2 0 .00 - < 0.01 1.00E00 1.00E00 thiamine phosphate phosphatase activity (GO:0042131) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidized pyrimidine DNA binding (GO:0032358) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidized purine DNA binding (GO:0032357) 10 0 .00 - < 0.01 1.00E00 1.00E00 oxidized DNA binding (GO:0032356) 11 0 .00 - < 0.01 1.00E00 1.00E00 (4S)-4-hydroxy-2-oxoglutarate aldolase activity (GO:0106009) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-binding transcription repressor activity (GO:0001217) 279 0 .08 - < 0.01 1.00E00 1.00E00 2-oxoglutaramate amidase activity (GO:0106008) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-binding transcription activator activity (GO:0001216) 439 0 .13 - < 0.01 1.00E00 1.00E00 cytoskeletal protein-membrane anchor activity (GO:0106006) 4 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled glutamate receptor activity (GO:0098988) 9 0 .00 - < 0.01 1.00E00 1.00E00 troponin C binding (GO:0030172) 3 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated proton channel activity (GO:0030171) 1 0 .00 - < 0.01 1.00E00 1.00E00 pyridoxal phosphate binding (GO:0030170) 55 0 .02 - < 0.01 1.00E00 1.00E00 low-density lipoprotein particle binding (GO:0030169) 17 0 .00 - < 0.01 1.00E00 1.00E00 PDZ domain binding (GO:0030165) 83 0 .02 - < 0.01 1.00E00 1.00E00 synaptic receptor adaptor activity (GO:0030160) 4 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of postsynaptic actin cytoskeleton (GO:0098973) 11 0 .00 - < 0.01 1.00E00 1.00E00 tetrahydrofolyl-poly(glutamate) polymer binding (GO:1904493) 1 0 .00 - < 0.01 1.00E00 1.00E00 eukaryotic initiation factor eIF2 binding (GO:0071074) 3 0 .00 - < 0.01 1.00E00 1.00E00 Ac-Asp-Glu binding (GO:1904492) 1 0 .00 - < 0.01 1.00E00 1.00E00 box H/ACA snoRNA binding (GO:0034513) 4 0 .00 - < 0.01 1.00E00 1.00E00 box C/D sno(s)RNA binding (GO:0034512) 1 0 .00 - < 0.01 1.00E00 1.00E00 U3 snoRNA binding (GO:0034511) 11 0 .00 - < 0.01 1.00E00 1.00E00 signaling receptor complex adaptor activity (GO:0030159) 52 0 .02 - < 0.01 1.00E00 1.00E00 protein xylosyltransferase activity (GO:0030158) 2 0 .00 - < 0.01 1.00E00 1.00E00 benzodiazepine receptor binding (GO:0030156) 5 0 .00 - < 0.01 1.00E00 1.00E00 molybdenum ion binding (GO:0030151) 4 0 .00 - < 0.01 1.00E00 1.00E00 postsynaptic neurotransmitter receptor activity (GO:0098960) 69 0 .02 - < 0.01 1.00E00 1.00E00 single-stranded DNA exodeoxyribonuclease activity (GO:0008297) 11 0 .00 - < 0.01 1.00E00 1.00E00 3'-5'-DNA exonuclease activity (GO:0008296) 17 0 .00 - < 0.01 1.00E00 1.00E00 calcium- and calmodulin-responsive adenylate cyclase activity (GO:0008294) 2 0 .00 - < 0.01 1.00E00 1.00E00 manganese ion binding (GO:0030145) 68 0 .02 - < 0.01 1.00E00 1.00E00 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity (GO:0030144) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein tyrosine kinase binding (GO:1990782) 117 0 .03 - < 0.01 1.00E00 1.00E00 protein-L-histidine N-tele-methyltransferase activity (GO:0018064) 2 0 .00 - < 0.01 1.00E00 1.00E00 lipid binding (GO:0008289) 860 1 .25 + 3.99 2.26E-01 1.00E00 boss receptor activity (GO:0008288) 49 0 .01 - < 0.01 1.00E00 1.00E00 sulfonylurea receptor activity (GO:0008281) 2 0 .00 - < 0.01 1.00E00 1.00E00 D-aminoacyl-tRNA deacylase activity (GO:0051499) 2 0 .00 - < 0.01 1.00E00 1.00E00 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity (GO:0043891) 2 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylgalactosamine-6-sulfatase activity (GO:0043890) 1 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) 12 0 .00 - < 0.01 1.00E00 1.00E00 protein methyltransferase activity (GO:0008276) 95 0 .03 - < 0.01 1.00E00 1.00E00 calcium, potassium:sodium antiporter activity (GO:0008273) 5 0 .00 - < 0.01 1.00E00 1.00E00 secondary active sulfate transmembrane transporter activity (GO:0008271) 11 0 .00 - < 0.01 1.00E00 1.00E00 zinc ion binding (GO:0008270) 2153 0 .63 - < 0.01 1.00E00 1.00E00 arrestin family protein binding (GO:1990763) 10 0 .00 - < 0.01 1.00E00 1.00E00 osmolarity-sensing monoatomic cation channel activity (GO:1990760) 5 0 .00 - < 0.01 1.00E00 1.00E00 JAK pathway signal transduction adaptor activity (GO:0008269) 3 0 .00 - < 0.01 1.00E00 1.00E00 D3 vitamins binding (GO:1902271) 3 0 .00 - < 0.01 1.00E00 1.00E00 poly(U) RNA binding (GO:0008266) 26 0 .01 - < 0.01 1.00E00 1.00E00 molybdenum cofactor sulfurtransferase activity (GO:0008265) 1 0 .00 - < 0.01 1.00E00 1.00E00 pyrimidine-specific mismatch base pair DNA N-glycosylase activity (GO:0008263) 2 0 .00 - < 0.01 1.00E00 1.00E00 glial cell-derived neurotrophic factor receptor binding (GO:0030116) 4 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin ligase activator activity (GO:1990757) 10 0 .00 - < 0.01 1.00E00 1.00E00 succinyl-CoA:3-oxo-acid CoA-transferase activity (GO:0008260) 2 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-like ligase-substrate adaptor activity (GO:1990756) 123 0 .04 - < 0.01 1.00E00 1.00E00 HLA-C specific inhibitory MHC class I receptor activity (GO:0030110) 1 0 .00 - < 0.01 1.00E00 1.00E00 acireductone synthase activity (GO:0043874) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-lysine N6-myristoyltransferase activity (GO:0018030) 2 0 .00 - < 0.01 1.00E00 1.00E00 HLA-B specific inhibitory MHC class I receptor activity (GO:0030109) 2 0 .00 - < 0.01 1.00E00 1.00E00 HLA-A specific activating MHC class I receptor activity (GO:0030108) 1 0 .00 - < 0.01 1.00E00 1.00E00 3'-nucleotidase activity (GO:0008254) 1 0 .00 - < 0.01 1.00E00 1.00E00 HLA-A specific inhibitory MHC class I receptor activity (GO:0030107) 1 0 .00 - < 0.01 1.00E00 1.00E00 5'-nucleotidase activity (GO:0008253) 13 0 .00 - < 0.01 1.00E00 1.00E00 5'-deoxynucleotidase activity (GO:0002953) 3 0 .00 - < 0.01 1.00E00 1.00E00 nucleotidase activity (GO:0008252) 15 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of postsynaptic density (GO:0098919) 4 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-specific adenosine deaminase activity (GO:0008251) 8 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of synapse (GO:0098918) 30 0 .01 - < 0.01 1.00E00 1.00E00 leukotriene-C(4) hydrolase (GO:0002951) 2 0 .00 - < 0.01 1.00E00 1.00E00 ceramide phosphoethanolamine synthase activity (GO:0002950) 3 0 .00 - < 0.01 1.00E00 1.00E00 adenyl-nucleotide exchange factor activity (GO:0000774) 15 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidyl-N-methylethanolamine N-methyltransferase activity (GO:0000773) 1 0 .00 - < 0.01 1.00E00 1.00E00 methionine transmembrane transporter activity (GO:0043865) 1 0 .00 - < 0.01 1.00E00 1.00E00 calmodulin-lysine N-methyltransferase activity (GO:0018025) 1 0 .00 - < 0.01 1.00E00 1.00E00 omega peptidase activity (GO:0008242) 15 0 .00 - < 0.01 1.00E00 1.00E00 pseudouridine 5'-phosphatase activity (GO:1990738) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-dipeptidase activity (GO:0008241) 2 0 .00 - < 0.01 1.00E00 1.00E00 tripeptidyl-peptidase activity (GO:0008240) 3 0 .00 - < 0.01 1.00E00 1.00E00 cyclic nucleotide-activated monoatomic ion channel activity (GO:0043855) 11 0 .00 - < 0.01 1.00E00 1.00E00 dipeptidyl-peptidase activity (GO:0008239) 10 0 .00 - < 0.01 1.00E00 1.00E00 exopeptidase activity (GO:0008238) 103 0 .03 - < 0.01 1.00E00 1.00E00 metallopeptidase activity (GO:0008237) 186 0 .05 - < 0.01 1.00E00 1.00E00 serine-type peptidase activity (GO:0008236) 195 0 .06 - < 0.01 1.00E00 1.00E00 metalloexopeptidase activity (GO:0008235) 70 0 .02 - < 0.01 1.00E00 1.00E00 cysteine-type peptidase activity (GO:0008234) 185 0 .05 - < 0.01 1.00E00 1.00E00 peptidase activity (GO:0008233) 617 0 .18 - < 0.01 1.00E00 1.00E00 V1B vasopressin receptor binding (GO:0031895) 1 0 .00 - < 0.01 1.00E00 1.00E00 V1A vasopressin receptor binding (GO:0031894) 3 0 .00 - < 0.01 1.00E00 1.00E00 vasopressin receptor binding (GO:0031893) 3 0 .00 - < 0.01 1.00E00 1.00E00 type 2 vasoactive intestinal polypeptide receptor binding (GO:0031892) 2 0 .00 - < 0.01 1.00E00 1.00E00 type 1 vasoactive intestinal polypeptide receptor binding (GO:0031891) 2 0 .00 - < 0.01 1.00E00 1.00E00 vasoactive intestinal polypeptide receptor binding (GO:0031890) 2 0 .00 - < 0.01 1.00E00 1.00E00 Ras palmitoyltransferase activity (GO:0043849) 1 0 .00 - < 0.01 1.00E00 1.00E00 ADP-specific glucokinase activity (GO:0043843) 1 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled amine receptor activity (GO:0008227) 41 0 .01 - < 0.01 1.00E00 1.00E00 telomerase inhibitor activity (GO:0010521) 6 0 .00 - < 0.01 1.00E00 1.00E00 mRNA CDS binding (GO:1990715) 3 0 .00 - < 0.01 1.00E00 1.00E00 taste receptor binding (GO:0031883) 1 0 .00 - < 0.01 1.00E00 1.00E00 BH3 domain binding (GO:0051434) 6 0 .00 - < 0.01 1.00E00 1.00E00 melatonin binding (GO:1904408) 1 0 .00 - < 0.01 1.00E00 1.00E00 corticotropin-releasing hormone receptor 2 binding (GO:0051431) 4 0 .00 - < 0.01 1.00E00 1.00E00 corticotropin-releasing hormone receptor 1 binding (GO:0051430) 4 0 .00 - < 0.01 1.00E00 1.00E00 somatostatin receptor binding (GO:0031877) 1 0 .00 - < 0.01 1.00E00 1.00E00 corticotropin-releasing hormone receptor binding (GO:0051429) 6 0 .00 - < 0.01 1.00E00 1.00E00 proteinase activated receptor binding (GO:0031871) 3 0 .00 - < 0.01 1.00E00 1.00E00 peptide hormone receptor binding (GO:0051428) 21 0 .01 - < 0.01 1.00E00 1.00E00 thromboxane A2 receptor binding (GO:0031870) 1 0 .00 - < 0.01 1.00E00 1.00E00 hormone receptor binding (GO:0051427) 34 0 .01 - < 0.01 1.00E00 1.00E00 PTB domain binding (GO:0051425) 3 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-specific adenosine-37 deaminase activity (GO:0043829) 1 0 .00 - < 0.01 1.00E00 1.00E00 corticotropin-releasing hormone binding (GO:0051424) 2 0 .00 - < 0.01 1.00E00 1.00E00 tubulin N-acetyltransferase activity (GO:0019799) 1 0 .00 - < 0.01 1.00E00 1.00E00 procollagen-proline dioxygenase activity (GO:0019798) 8 0 .00 - < 0.01 1.00E00 1.00E00 procollagen-proline 3-dioxygenase activity (GO:0019797) 3 0 .00 - < 0.01 1.00E00 1.00E00 EP4 subtype prostaglandin E2 receptor binding (GO:0031867) 1 0 .00 - < 0.01 1.00E00 1.00E00 heparin binding (GO:0008201) 171 0 .05 - < 0.01 1.00E00 1.00E00 ion channel inhibitor activity (GO:0008200) 43 0 .01 - < 0.01 1.00E00 1.00E00 prostanoid receptor binding (GO:0031862) 2 0 .00 - < 0.01 1.00E00 1.00E00 prolactin-releasing peptide receptor binding (GO:0031861) 1 0 .00 - < 0.01 1.00E00 1.00E00 (R,R)-butanediol dehydrogenase activity (GO:0000721) 1 0 .00 - < 0.01 1.00E00 1.00E00 SUMO transferase activity (GO:0019789) 28 0 .01 - < 0.01 1.00E00 1.00E00 NEDD8 transferase activity (GO:0019788) 6 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-like protein transferase activity (GO:0019787) 479 0 .14 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity (GO:0043813) 7 0 .00 - < 0.01 1.00E00 1.00E00 protein-phosphatidylethanolamide deconjugating activity (GO:0019786) 4 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-4-phosphate phosphatase activity (GO:0043812) 4 0 .00 - < 0.01 1.00E00 1.00E00 ISG15-specific peptidase activity (GO:0019785) 2 0 .00 - < 0.01 1.00E00 1.00E00 deNEDDylase activity (GO:0019784) 6 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-like protein peptidase activity (GO:0019783) 128 0 .04 - < 0.01 1.00E00 1.00E00 ISG15 activating enzyme activity (GO:0019782) 1 0 .00 - < 0.01 1.00E00 1.00E00 NEDD8 activating enzyme activity (GO:0019781) 2 0 .00 - < 0.01 1.00E00 1.00E00 FAT10 activating enzyme activity (GO:0019780) 1 0 .00 - < 0.01 1.00E00 1.00E00 type 1 parathyroid hormone receptor binding (GO:0031857) 1 0 .00 - < 0.01 1.00E00 1.00E00 parathyroid hormone receptor binding (GO:0031856) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxytocin receptor binding (GO:0031855) 1 0 .00 - < 0.01 1.00E00 1.00E00 orexigenic neuropeptide QRFP receptor binding (GO:0031854) 1 0 .00 - < 0.01 1.00E00 1.00E00 mu-type opioid receptor binding (GO:0031852) 2 0 .00 - < 0.01 1.00E00 1.00E00 kappa-type opioid receptor binding (GO:0031851) 1 0 .00 - < 0.01 1.00E00 1.00E00 CH domain binding (GO:0051401) 1 0 .00 - < 0.01 1.00E00 1.00E00 Atg8 activating enzyme activity (GO:0019779) 1 0 .00 - < 0.01 1.00E00 1.00E00 BH domain binding (GO:0051400) 9 0 .00 - < 0.01 1.00E00 1.00E00 Atg12 activating enzyme activity (GO:0019778) 1 0 .00 - < 0.01 1.00E00 1.00E00 Atg12 transferase activity (GO:0019777) 2 0 .00 - < 0.01 1.00E00 1.00E00 Atg8-family ligase activity (GO:0019776) 3 0 .00 - < 0.01 1.00E00 1.00E00 low-affinity IgG receptor activity (GO:0019772) 2 0 .00 - < 0.01 1.00E00 1.00E00 high-affinity IgG receptor activity (GO:0019771) 1 0 .00 - < 0.01 1.00E00 1.00E00 IgG receptor activity (GO:0019770) 7 0 .00 - < 0.01 1.00E00 1.00E00 olfactory receptor binding (GO:0031849) 6 0 .00 - < 0.01 1.00E00 1.00E00 neuropeptide Y receptor binding (GO:0031841) 4 0 .00 - < 0.01 1.00E00 1.00E00 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity (GO:0000703) 2 0 .00 - < 0.01 1.00E00 1.00E00 type 2 neuromedin U receptor binding (GO:0031840) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidized base lesion DNA N-glycosylase activity (GO:0000702) 4 0 .00 - < 0.01 1.00E00 1.00E00 purine-specific mismatch base pair DNA N-glycosylase activity (GO:0000701) 2 0 .00 - < 0.01 1.00E00 1.00E00 mismatch base pair DNA N-glycosylase activity (GO:0000700) 4 0 .00 - < 0.01 1.00E00 1.00E00 low-affinity IgE receptor activity (GO:0019769) 1 0 .00 - < 0.01 1.00E00 1.00E00 high-affinity IgE receptor activity (GO:0019768) 1 0 .00 - < 0.01 1.00E00 1.00E00 IgE receptor activity (GO:0019767) 3 0 .00 - < 0.01 1.00E00 1.00E00 IgA receptor activity (GO:0019766) 1 0 .00 - < 0.01 1.00E00 1.00E00 immunoglobulin receptor activity (GO:0019763) 14 0 .00 - < 0.01 1.00E00 1.00E00 5-methylcytosine dioxygenase activity (GO:0070579) 3 0 .00 - < 0.01 1.00E00 1.00E00 lysine-acetylated histone binding (GO:0070577) 21 0 .01 - < 0.01 1.00E00 1.00E00 vitamin D 24-hydroxylase activity (GO:0070576) 3 0 .00 - < 0.01 1.00E00 1.00E00 metallodipeptidase activity (GO:0070573) 8 0 .00 - < 0.01 1.00E00 1.00E00 type 1 neuromedin U receptor binding (GO:0031839) 1 0 .00 - < 0.01 1.00E00 1.00E00 substance K receptor binding (GO:0031837) 3 0 .00 - < 0.01 1.00E00 1.00E00 neuromedin K receptor binding (GO:0031836) 2 0 .00 - < 0.01 1.00E00 1.00E00 pseudouridine synthase activity (GO:0009982) 13 0 .00 - < 0.01 1.00E00 1.00E00 substance P receptor binding (GO:0031835) 2 0 .00 - < 0.01 1.00E00 1.00E00 neurokinin receptor binding (GO:0031834) 3 0 .00 - < 0.01 1.00E00 1.00E00 uridylyltransferase activity (GO:0070569) 7 0 .00 - < 0.01 1.00E00 1.00E00 guanylyltransferase activity (GO:0070568) 7 0 .00 - < 0.01 1.00E00 1.00E00 cytidylyltransferase activity (GO:0070567) 9 0 .00 - < 0.01 1.00E00 1.00E00 adenylyltransferase activity (GO:0070566) 30 0 .01 - < 0.01 1.00E00 1.00E00 enterobactin binding (GO:1903981) 2 0 .00 - < 0.01 1.00E00 1.00E00 primary active transmembrane transporter activity (GO:0015399) 164 0 .05 - < 0.01 1.00E00 1.00E00 cyclase activity (GO:0009975) 22 0 .01 - < 0.01 1.00E00 1.00E00 nucleobase:monoatomic cation symporter activity (GO:0015391) 4 0 .00 - < 0.01 1.00E00 1.00E00 purine-specific nucleoside:sodium symporter activity (GO:0015390) 1 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled serotonin receptor binding (GO:0031821) 3 0 .00 - < 0.01 1.00E00 1.00E00 nicotinic acid receptor activity (GO:0070553) 2 0 .00 - < 0.01 1.00E00 1.00E00 pyrimidine- and adenosine-specific:sodium symporter activity (GO:0015389) 4 0 .00 - < 0.01 1.00E00 1.00E00 endoribonuclease activity, cleaving siRNA-paired mRNA (GO:0070551) 1 0 .00 - < 0.01 1.00E00 1.00E00 potassium:proton antiporter activity (GO:0015386) 14 0 .00 - < 0.01 1.00E00 1.00E00 sodium:proton antiporter activity (GO:0015385) 16 0 .00 - < 0.01 1.00E00 1.00E00 peptide histaminyltransferase activity (GO:0120299) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptide noradrenalinyltransferase activity (GO:0120298) 1 0 .00 - < 0.01 1.00E00 1.00E00 sulfate:bicarbonate antiporter activity (GO:0015383) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone dopaminyltransferase activity (GO:0120297) 1 0 .00 - < 0.01 1.00E00 1.00E00 sodium:sulfate symporter activity (GO:0015382) 2 0 .00 - < 0.01 1.00E00 1.00E00 peptide dopaminyltransferase activity (GO:0120296) 1 0 .00 - < 0.01 1.00E00 1.00E00 P2Y1 nucleotide receptor binding (GO:0031812) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone serotonyltransferase activity (GO:0120295) 1 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled nucleotide receptor binding (GO:0031811) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptide serotonyltransferase activity (GO:0120294) 1 0 .00 - < 0.01 1.00E00 1.00E00 nitric-oxide synthase binding (GO:0050998) 11 0 .00 - < 0.01 1.00E00 1.00E00 quaternary ammonium group binding (GO:0050997) 40 0 .01 - < 0.01 1.00E00 1.00E00 L-glutamine aminotransferase activity (GO:0070548) 3 0 .00 - < 0.01 1.00E00 1.00E00 potassium:chloride symporter activity (GO:0015379) 9 0 .00 - < 0.01 1.00E00 1.00E00 sodium:chloride symporter activity (GO:0015378) 16 0 .00 - < 0.01 1.00E00 1.00E00 chloride:monoatomic cation symporter activity (GO:0015377) 22 0 .01 - < 0.01 1.00E00 1.00E00 glycine:sodium symporter activity (GO:0015375) 3 0 .00 - < 0.01 1.00E00 1.00E00 neutral, basic amino acid:sodium:chloride symporter activity (GO:0015374) 1 0 .00 - < 0.01 1.00E00 1.00E00 monoatomic anion:sodium symporter activity (GO:0015373) 18 0 .01 - < 0.01 1.00E00 1.00E00 galactose:sodium symporter activity (GO:0015371) 1 0 .00 - < 0.01 1.00E00 1.00E00 type 5 metabotropic glutamate receptor binding (GO:0031802) 6 0 .00 - < 0.01 1.00E00 1.00E00 solute:sodium symporter activity (GO:0015370) 79 0 .02 - < 0.01 1.00E00 1.00E00 type 3 metabotropic glutamate receptor binding (GO:0031800) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein serine/threonine kinase binding (GO:0120283) 18 0 .01 - < 0.01 1.00E00 1.00E00 linoleic acid binding (GO:0070539) 1 0 .00 - < 0.01 1.00E00 1.00E00 oleic acid binding (GO:0070538) 3 0 .00 - < 0.01 1.00E00 1.00E00 calcium:proton antiporter activity (GO:0015369) 2 0 .00 - < 0.01 1.00E00 1.00E00 calcium:monoatomic cation antiporter activity (GO:0015368) 12 0 .00 - < 0.01 1.00E00 1.00E00 oxoglutarate:malate antiporter activity (GO:0015367) 1 0 .00 - < 0.01 1.00E00 1.00E00 K63-linked polyubiquitin modification-dependent protein binding (GO:0070530) 25 0 .01 - < 0.01 1.00E00 1.00E00 high-affinity sodium:dicarboxylate symporter activity (GO:0015362) 1 0 .00 - < 0.01 1.00E00 1.00E00 low-affinity sodium:dicarboxylate symporter activity (GO:0015361) 1 0 .00 - < 0.01 1.00E00 1.00E00 virus coreceptor activity (GO:0120274) 1 0 .00 - < 0.01 1.00E00 1.00E00 11-beta-hydroxysteroid dehydrogenase (NADP+) activity (GO:0070524) 1 0 .00 - < 0.01 1.00E00 1.00E00 11-beta-hydroxysteroid dehydrogenase (NAD+) activity (GO:0070523) 1 0 .00 - < 0.01 1.00E00 1.00E00 secondary active monocarboxylate transmembrane transporter activity (GO:0015355) 19 0 .01 - < 0.01 1.00E00 1.00E00 calcium-dependent protein serine/threonine kinase activity (GO:0009931) 21 0 .01 - < 0.01 1.00E00 1.00E00 methotrexate transmembrane transporter activity (GO:0015350) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein-cysteine S-acyltransferase activity (GO:0019707) 26 0 .01 - < 0.01 1.00E00 1.00E00 protein-cysteine S-palmitoyltransferase activity (GO:0019706) 26 0 .01 - < 0.01 1.00E00 1.00E00 protein-cysteine S-myristoyltransferase activity (GO:0019705) 6 0 .00 - < 0.01 1.00E00 1.00E00 death domain binding (GO:0070513) 9 0 .00 - < 0.01 1.00E00 1.00E00 thyroid hormone transmembrane transporter activity (GO:0015349) 8 0 .00 - < 0.01 1.00E00 1.00E00 sodium-independent organic anion transmembrane transporter activity (GO:0015347) 17 0 .00 - < 0.01 1.00E00 1.00E00 mitochondrial ribosome binding (GO:0097177) 10 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid elongase activity (GO:0009922) 7 0 .00 - < 0.01 1.00E00 1.00E00 siderophore-iron transmembrane transporter activity (GO:0015343) 1 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid omega-hydroxylase activity (GO:0120250) 8 0 .00 - < 0.01 1.00E00 1.00E00 high-density lipoprotein particle receptor activity (GO:0070506) 2 0 .00 - < 0.01 1.00E00 1.00E00 peptide:proton symporter activity (GO:0015333) 4 0 .00 - < 0.01 1.00E00 1.00E00 sulfur carrier activity (GO:0097163) 1 0 .00 - < 0.01 1.00E00 1.00E00 MADS box domain binding (GO:0097162) 1 0 .00 - < 0.01 1.00E00 1.00E00 DH domain binding (GO:0097161) 1 0 .00 - < 0.01 1.00E00 1.00E00 polychlorinated biphenyl binding (GO:0097160) 1 0 .00 - < 0.01 1.00E00 1.00E00 2-iminopropanoate deaminase activity (GO:0120243) 1 0 .00 - < 0.01 1.00E00 1.00E00 2-iminobutanoate deaminase activity (GO:0120242) 1 0 .00 - < 0.01 1.00E00 1.00E00 2-iminobutanoate/2-iminopropanoate deaminase (GO:0120241) 1 0 .00 - < 0.01 1.00E00 1.00E00 cystine:glutamate antiporter activity (GO:0015327) 1 0 .00 - < 0.01 1.00E00 1.00E00 pre-mRNA intronic pyrimidine-rich binding (GO:0097158) 2 0 .00 - < 0.01 1.00E00 1.00E00 pre-mRNA intronic binding (GO:0097157) 13 0 .00 - < 0.01 1.00E00 1.00E00 odorant binding (GO:0005549) 113 0 .03 - < 0.01 1.00E00 1.00E00 phospholipid transporter activity (GO:0005548) 71 0 .02 - < 0.01 1.00E00 1.00E00 recombinase activator activity (GO:0120230) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547) 41 0 .01 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-4,5-bisphosphate binding (GO:0005546) 86 0 .03 - < 0.01 1.00E00 1.00E00 1-phosphatidylinositol binding (GO:0005545) 14 0 .00 - < 0.01 1.00E00 1.00E00 calcium-dependent phospholipid binding (GO:0005544) 54 0 .02 - < 0.01 1.00E00 1.00E00 phospholipid binding (GO:0005543) 497 0 .14 - < 0.01 1.00E00 1.00E00 folic acid binding (GO:0005542) 12 0 .00 - < 0.01 1.00E00 1.00E00 hyaluronic acid binding (GO:0005540) 24 0 .01 - < 0.01 1.00E00 1.00E00 inorganic molecular entity transmembrane transporter activity (GO:0015318) 734 0 .21 - < 0.01 1.00E00 1.00E00 phosphate:proton symporter activity (GO:0015317) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase I general transcription initiation factor activity (GO:0001181) 8 0 .00 - < 0.01 1.00E00 1.00E00 organophosphate:phosphate antiporter activity (GO:0015315) 6 0 .00 - < 0.01 1.00E00 1.00E00 acyl-CoA binding (GO:0120227) 18 0 .01 - < 0.01 1.00E00 1.00E00 polyamine:proton antiporter activity (GO:0015312) 1 0 .00 - < 0.01 1.00E00 1.00E00 monoamine:proton antiporter activity (GO:0015311) 4 0 .00 - < 0.01 1.00E00 1.00E00 coenzyme A binding (GO:0120225) 3 0 .00 - < 0.01 1.00E00 1.00E00 deoxyribonuclease inhibitor activity (GO:0060703) 3 0 .00 - < 0.01 1.00E00 1.00E00 glycosaminoglycan binding (GO:0005539) 241 0 .07 - < 0.01 1.00E00 1.00E00 D-mannose binding (GO:0005537) 25 0 .01 - < 0.01 1.00E00 1.00E00 D-glucose binding (GO:0005536) 11 0 .00 - < 0.01 1.00E00 1.00E00 galactose binding (GO:0005534) 4 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase I general transcription initiation factor binding (GO:0001179) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-glucose uniporter activity (GO:0015304) 1 0 .00 - < 0.01 1.00E00 1.00E00 FK506 binding (GO:0005528) 10 0 .00 - < 0.01 1.00E00 1.00E00 macrolide binding (GO:0005527) 12 0 .00 - < 0.01 1.00E00 1.00E00 GTP binding (GO:0005525) 382 0 .11 - < 0.01 1.00E00 1.00E00 5-methyltetrahydrofolate-dependent methyltransferase activity (GO:0042084) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATP binding (GO:0005524) 1479 0 .43 - < 0.01 1.00E00 1.00E00 5,10-methylenetetrahydrofolate-dependent methyltransferase activity (GO:0042083) 1 0 .00 - < 0.01 1.00E00 1.00E00 tropomyosin binding (GO:0005523) 15 0 .00 - < 0.01 1.00E00 1.00E00 profilin binding (GO:0005522) 10 0 .00 - < 0.01 1.00E00 1.00E00 lamin binding (GO:0005521) 16 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity (GO:0034485) 8 0 .00 - < 0.01 1.00E00 1.00E00 insulin-like growth factor binding (GO:0005520) 19 0 .01 - < 0.01 1.00E00 1.00E00 heparan sulfate sulfotransferase activity (GO:0034483) 15 0 .00 - < 0.01 1.00E00 1.00E00 chondroitin 2-sulfotransferase activity (GO:0034482) 1 0 .00 - < 0.01 1.00E00 1.00E00 chondroitin sulfotransferase activity (GO:0034481) 7 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylcholine phospholipase C activity (GO:0034480) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase I cis-regulatory region sequence-specific DNA binding (GO:0001165) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase I core promoter sequence-specific DNA binding (GO:0001164) 10 0 .00 - < 0.01 1.00E00 1.00E00 leptomycin B binding (GO:1901707) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase I transcription regulatory region sequence-specific DNA binding (GO:0001163) 11 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding (GO:0001162) 8 0 .00 - < 0.01 1.00E00 1.00E00 intronic transcription regulatory region sequence-specific DNA binding (GO:0001161) 11 0 .00 - < 0.01 1.00E00 1.00E00 salt transmembrane transporter activity (GO:1901702) 9 0 .00 - < 0.01 1.00E00 1.00E00 cytoskeletal regulatory protein binding (GO:0005519) 1 0 .00 - < 0.01 1.00E00 1.00E00 collagen binding (GO:0005518) 72 0 .02 - < 0.01 1.00E00 1.00E00 calmodulin binding (GO:0005516) 208 0 .06 - < 0.01 1.00E00 1.00E00 protein binding (GO:0005515) 14720 5 4.29 + 1.17 1.00E00 1.00E00 double-stranded RNA-specific ribonuclease activity (GO:0032296) 2 0 .00 - < 0.01 1.00E00 1.00E00 TFIIIC-class transcription factor complex binding (GO:0001156) 2 0 .00 - < 0.01 1.00E00 1.00E00 scaffold protein binding (GO:0097110) 70 0 .02 - < 0.01 1.00E00 1.00E00 calcium ion binding (GO:0005509) 707 0 .21 - < 0.01 1.00E00 1.00E00 copper ion binding (GO:0005507) 62 0 .02 - < 0.01 1.00E00 1.00E00 iron ion binding (GO:0005506) 154 1 .04 + 22.27 4.41E-02 1.00E00 fatty acid binding (GO:0005504) 47 0 .01 - < 0.01 1.00E00 1.00E00 all-trans retinal binding (GO:0005503) 5 0 .00 - < 0.01 1.00E00 1.00E00 11-cis retinal binding (GO:0005502) 7 0 .00 - < 0.01 1.00E00 1.00E00 retinoid binding (GO:0005501) 38 0 .01 - < 0.01 1.00E00 1.00E00 transcription termination site sequence-specific DNA binding (GO:0001147) 2 0 .00 - < 0.01 1.00E00 1.00E00 neuroligin family protein binding (GO:0097109) 5 0 .00 - < 0.01 1.00E00 1.00E00 hedgehog family protein binding (GO:0097108) 3 0 .00 - < 0.01 1.00E00 1.00E00 supercoiled DNA binding (GO:0097100) 5 0 .00 - < 0.01 1.00E00 1.00E00 chemoattractant activity (GO:0042056) 41 0 .01 - < 0.01 1.00E00 1.00E00 histone methyltransferase activity (GO:0042054) 67 0 .02 - < 0.01 1.00E00 1.00E00 3'-5' RNA helicase activity (GO:0034458) 7 0 .00 - < 0.01 1.00E00 1.00E00 dynactin binding (GO:0034452) 12 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-ubiquitin ligase activity (GO:0034450) 16 0 .00 - < 0.01 1.00E00 1.00E00 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity (GO:0046404) 4 0 .00 - < 0.01 1.00E00 1.00E00 polynucleotide 3'-phosphatase activity (GO:0046403) 2 0 .00 - < 0.01 1.00E00 1.00E00 neurexin family protein binding (GO:0042043) 15 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3-phosphate binding (GO:0032266) 48 0 .01 - < 0.01 1.00E00 1.00E00 ATPase inhibitor activity (GO:0042030) 6 0 .00 - < 0.01 1.00E00 1.00E00 bis(5'-adenosyl)-pentaphosphatase activity (GO:0034432) 6 0 .00 - < 0.01 1.00E00 1.00E00 bis(5'-adenosyl)-hexaphosphatase activity (GO:0034431) 5 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of presynaptic active zone (GO:0098882) 7 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-23 receptor activity (GO:0042020) 2 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of postsynaptic specialization (GO:0098879) 5 0 .00 - < 0.01 1.00E00 1.00E00 L-malate dehydrogenase (NAD+) activity (GO:0030060) 4 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration (GO:0098872) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-23 binding (GO:0042019) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-22 receptor activity (GO:0042018) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-22 binding (GO:0042017) 1 0 .00 - < 0.01 1.00E00 1.00E00 heparan sulfate binding (GO:1904399) 9 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-20 binding (GO:0042015) 3 0 .00 - < 0.01 1.00E00 1.00E00 bisphosphoglycerate 3-phosphatase activity (GO:0034417) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-16 receptor activity (GO:0042012) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-16 binding (GO:0042011) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-15 receptor activity (GO:0042010) 3 0 .00 - < 0.01 1.00E00 1.00E00 aliphatic amine dehydrogenase activity (GO:0030058) 3 0 .00 - < 0.01 1.00E00 1.00E00 palmitoleyl hydrolase activity (GO:1990699) 1 0 .00 - < 0.01 1.00E00 1.00E00 palmitoleoyltransferase activity (GO:1990698) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-18 receptor activity (GO:0042008) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-18 binding (GO:0042007) 2 0 .00 - < 0.01 1.00E00 1.00E00 ferric iron binding (GO:0008199) 11 0 .00 - < 0.01 1.00E00 1.00E00 ferrous iron binding (GO:0008198) 26 0 .01 - < 0.01 1.00E00 1.00E00 phosphatidate phosphatase activity (GO:0008195) 14 0 .00 - < 0.01 1.00E00 1.00E00 UDP-glycosyltransferase activity (GO:0008194) 145 0 .04 - < 0.01 1.00E00 1.00E00 tRNA guanylyltransferase activity (GO:0008193) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA guanylyltransferase activity (GO:0008192) 2 0 .00 - < 0.01 1.00E00 1.00E00 metalloendopeptidase inhibitor activity (GO:0008191) 14 0 .00 - < 0.01 1.00E00 1.00E00 eukaryotic initiation factor 4E binding (GO:0008190) 10 0 .00 - < 0.01 1.00E00 1.00E00 riboflavin transmembrane transporter activity (GO:0032217) 6 0 .00 - < 0.01 1.00E00 1.00E00 glucosaminyl-phosphatidylinositol O-acyltransferase activity (GO:0032216) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H4 acetyltransferase activity (GO:0010485) 33 0 .01 - < 0.01 1.00E00 1.00E00 neuropeptide receptor activity (GO:0008188) 48 0 .01 - < 0.01 1.00E00 1.00E00 histone H3 acetyltransferase activity (GO:0010484) 27 0 .01 - < 0.01 1.00E00 1.00E00 poly-pyrimidine tract binding (GO:0008187) 29 0 .01 - < 0.01 1.00E00 1.00E00 ATP-dependent activity, acting on RNA (GO:0008186) 79 0 .02 - < 0.01 1.00E00 1.00E00 glycogen phosphorylase activity (GO:0008184) 3 0 .00 - < 0.01 1.00E00 1.00E00 sequence-specific single stranded DNA binding (GO:0098847) 14 0 .00 - < 0.01 1.00E00 1.00E00 glycine oxidase activity (GO:0043799) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-actinin binding (GO:0051393) 28 0 .01 - < 0.01 1.00E00 1.00E00 tRNA N4-acetyltransferase activity (GO:0051392) 1 0 .00 - < 0.01 1.00E00 1.00E00 glyceraldehyde oxidoreductase activity (GO:0043795) 1 0 .00 - < 0.01 1.00E00 1.00E00 adenylate cyclase binding (GO:0008179) 12 0 .00 - < 0.01 1.00E00 1.00E00 succinate dehydrogenase (quinone) activity (GO:0008177) 3 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (guanine(46)-N7)-methyltransferase activity (GO:0008176) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA methyltransferase activity (GO:0008175) 33 0 .01 - < 0.01 1.00E00 1.00E00 mRNA methyltransferase activity (GO:0008174) 14 0 .00 - < 0.01 1.00E00 1.00E00 RNA methyltransferase activity (GO:0008173) 67 0 .02 - < 0.01 1.00E00 1.00E00 S-methyltransferase activity (GO:0008172) 11 0 .00 - < 0.01 1.00E00 1.00E00 O-methyltransferase activity (GO:0008171) 24 0 .01 - < 0.01 1.00E00 1.00E00 N-methyltransferase activity (GO:0008170) 98 0 .03 - < 0.01 1.00E00 1.00E00 extracellular matrix constituent conferring elasticity (GO:0030023) 9 0 .00 - < 0.01 1.00E00 1.00E00 extracellular matrix structural constituent conferring compression resistance (GO:0030021) 22 0 .01 - < 0.01 1.00E00 1.00E00 extracellular matrix structural constituent conferring tensile strength (GO:0030020) 44 0 .01 - < 0.01 1.00E00 1.00E00 norepinephrine binding (GO:0051380) 4 0 .00 - < 0.01 1.00E00 1.00E00 C-methyltransferase activity (GO:0008169) 6 0 .00 - < 0.01 1.00E00 1.00E00 nerve growth factor receptor activity (GO:0010465) 2 0 .00 - < 0.01 1.00E00 1.00E00 methyltransferase activity (GO:0008168) 205 0 .06 - < 0.01 1.00E00 1.00E00 protein tyrosine phosphatase activator activity (GO:0008160) 5 0 .00 - < 0.01 1.00E00 1.00E00 epinephrine binding (GO:0051379) 6 0 .00 - < 0.01 1.00E00 1.00E00 serotonin binding (GO:0051378) 10 0 .00 - < 0.01 1.00E00 1.00E00 mannose-ethanolamine phosphotransferase activity (GO:0051377) 3 0 .00 - < 0.01 1.00E00 1.00E00 BMP receptor activity (GO:0098821) 14 0 .00 - < 0.01 1.00E00 1.00E00 FATZ binding (GO:0051373) 5 0 .00 - < 0.01 1.00E00 1.00E00 muscle alpha-actinin binding (GO:0051371) 15 0 .00 - < 0.01 1.00E00 1.00E00 cytidine kinase activity (GO:0043771) 4 0 .00 - < 0.01 1.00E00 1.00E00 hedgehog receptor activity (GO:0008158) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein phosphatase 1 binding (GO:0008157) 26 0 .01 - < 0.01 1.00E00 1.00E00 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity (GO:0033989) 1 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of bone (GO:0008147) 2 0 .00 - < 0.01 1.00E00 1.00E00 sulfotransferase activity (GO:0008146) 53 0 .02 - < 0.01 1.00E00 1.00E00 endopeptidase regulator activity (GO:0061135) 197 0 .06 - < 0.01 1.00E00 1.00E00 peptidase regulator activity (GO:0061134) 234 0 .07 - < 0.01 1.00E00 1.00E00 poly(A) binding (GO:0008143) 25 0 .01 - < 0.01 1.00E00 1.00E00 D-dopachrome decarboxylase activity (GO:0033981) 1 0 .00 - < 0.01 1.00E00 1.00E00 endopeptidase activator activity (GO:0061133) 27 0 .01 - < 0.01 1.00E00 1.00E00 oxysterol binding (GO:0008142) 16 0 .00 - < 0.01 1.00E00 1.00E00 nitrite reductase activity (GO:0098809) 8 0 .00 - < 0.01 1.00E00 1.00E00 mRNA cap binding (GO:0098808) 4 0 .00 - < 0.01 1.00E00 1.00E00 cAMP response element binding protein binding (GO:0008140) 10 0 .00 - < 0.01 1.00E00 1.00E00 2-methylbutanoate-CoA ligase activity (GO:0043759) 1 0 .00 - < 0.01 1.00E00 1.00E00 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity (GO:0043754) 1 0 .00 - < 0.01 1.00E00 1.00E00 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity (GO:0010437) 1 0 .00 - < 0.01 1.00E00 1.00E00 carotenoid dioxygenase activity (GO:0010436) 2 0 .00 - < 0.01 1.00E00 1.00E00 nuclear localization sequence binding (GO:0008139) 25 0 .01 - < 0.01 1.00E00 1.00E00 protein tyrosine/serine/threonine phosphatase activity (GO:0008138) 27 0 .01 - < 0.01 1.00E00 1.00E00 NADH dehydrogenase (ubiquinone) activity (GO:0008137) 41 0 .01 - < 0.01 1.00E00 1.00E00 translation factor activity, RNA binding (GO:0008135) 84 0 .02 - < 0.01 1.00E00 1.00E00 transcription factor binding (GO:0008134) 594 0 .17 - < 0.01 1.00E00 1.00E00 type 2 metabotropic glutamate receptor binding (GO:0031799) 2 0 .00 - < 0.01 1.00E00 1.00E00 type 1 metabotropic glutamate receptor binding (GO:0031798) 1 0 .00 - < 0.01 1.00E00 1.00E00 primary methylamine oxidase activity (GO:0008131) 9 0 .00 - < 0.01 1.00E00 1.00E00 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) 53 0 .02 - < 0.01 1.00E00 1.00E00 methyl-CpNpG binding (GO:0010428) 1 0 .00 - < 0.01 1.00E00 1.00E00 quercetin 2,3-dioxygenase activity (GO:0008127) 1 0 .00 - < 0.01 1.00E00 1.00E00 acetylesterase activity (GO:0008126) 5 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol-5,6-oxide hydrolase activity (GO:0033963) 2 0 .00 - < 0.01 1.00E00 1.00E00 4-alpha-hydroxytetrahydrobiopterin dehydratase activity (GO:0008124) 2 0 .00 - < 0.01 1.00E00 1.00E00 polyprenyldihydroxybenzoate methyltransferase activity (GO:0010420) 1 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol 7-alpha-monooxygenase activity (GO:0008123) 1 0 .00 - < 0.01 1.00E00 1.00E00 motilin receptor binding (GO:0031788) 1 0 .00 - < 0.01 1.00E00 1.00E00 cis-stilbene-oxide hydrolase activity (GO:0033961) 1 0 .00 - < 0.01 1.00E00 1.00E00 ubiquinol-cytochrome-c reductase activity (GO:0008121) 7 0 .00 - < 0.01 1.00E00 1.00E00 ceramide glucosyltransferase activity (GO:0008120) 1 0 .00 - < 0.01 1.00E00 1.00E00 type 5 melanocortin receptor binding (GO:0031783) 2 0 .00 - < 0.01 1.00E00 1.00E00 type 4 melanocortin receptor binding (GO:0031782) 4 0 .00 - < 0.01 1.00E00 1.00E00 type 3 melanocortin receptor binding (GO:0031781) 4 0 .00 - < 0.01 1.00E00 1.00E00 corticotropin hormone receptor binding (GO:0031780) 2 0 .00 - < 0.01 1.00E00 1.00E00 G/U mismatch-specific uracil-DNA glycosylase activity (GO:0043739) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-3-methylbase glycosylase activity (GO:0043733) 1 0 .00 - < 0.01 1.00E00 1.00E00 thiopurine S-methyltransferase activity (GO:0008119) 1 0 .00 - < 0.01 1.00E00 1.00E00 chenodeoxycholic acid binding (GO:1902122) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetyllactosaminide alpha-2,3-sialyltransferase activity (GO:0008118) 3 0 .00 - < 0.01 1.00E00 1.00E00 lithocholic acid binding (GO:1902121) 1 0 .00 - < 0.01 1.00E00 1.00E00 sphinganine-1-phosphate aldolase activity (GO:0008117) 1 0 .00 - < 0.01 1.00E00 1.00E00 prostaglandin-I synthase activity (GO:0008116) 1 0 .00 - < 0.01 1.00E00 1.00E00 sarcosine oxidase activity (GO:0008115) 1 0 .00 - < 0.01 1.00E00 1.00E00 melanocortin receptor binding (GO:0031779) 5 0 .00 - < 0.01 1.00E00 1.00E00 peptide-methionine (S)-S-oxide reductase activity (GO:0008113) 2 0 .00 - < 0.01 1.00E00 1.00E00 nicotinamide N-methyltransferase activity (GO:0008112) 1 0 .00 - < 0.01 1.00E00 1.00E00 type 1 melanin-concentrating hormone receptor binding (GO:0031777) 3 0 .00 - < 0.01 1.00E00 1.00E00 glutamate-cysteine ligase regulator activity (GO:1990609) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-methylacyl-CoA racemase activity (GO:0008111) 1 0 .00 - < 0.01 1.00E00 1.00E00 melanin-concentrating hormone receptor binding (GO:0031776) 3 0 .00 - < 0.01 1.00E00 1.00E00 kisspeptin receptor binding (GO:0031773) 1 0 .00 - < 0.01 1.00E00 1.00E00 type 2 orexin receptor binding (GO:0031772) 1 0 .00 - < 0.01 1.00E00 1.00E00 type 1 orexin receptor binding (GO:0031771) 1 0 .00 - < 0.01 1.00E00 1.00E00 growth hormone-releasing hormone receptor binding (GO:0031770) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcidiol binding (GO:1902118) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity (GO:0008109) 3 0 .00 - < 0.01 1.00E00 1.00E00 UDP-glucose:hexose-1-phosphate uridylyltransferase activity (GO:0008108) 1 0 .00 - < 0.01 1.00E00 1.00E00 galactoside 2-alpha-L-fucosyltransferase activity (GO:0008107) 2 0 .00 - < 0.01 1.00E00 1.00E00 alcohol dehydrogenase (NADP+) activity (GO:0008106) 30 1 .01 + > 100 8.72E-03 1.00E00 glucagon receptor binding (GO:0031769) 2 0 .00 - < 0.01 1.00E00 1.00E00 ghrelin receptor binding (GO:0031768) 1 0 .00 - < 0.01 1.00E00 1.00E00 gastric inhibitory polypeptide receptor binding (GO:0031767) 2 0 .00 - < 0.01 1.00E00 1.00E00 type 3 galanin receptor binding (GO:0031766) 2 0 .00 - < 0.01 1.00E00 1.00E00 type 2 galanin receptor binding (GO:0031765) 2 0 .00 - < 0.01 1.00E00 1.00E00 type 1 galanin receptor binding (GO:0031764) 1 0 .00 - < 0.01 1.00E00 1.00E00 galanin receptor binding (GO:0031763) 2 0 .00 - < 0.01 1.00E00 1.00E00 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity (GO:0043716) 1 0 .00 - < 0.01 1.00E00 1.00E00 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity (GO:0043715) 1 0 .00 - < 0.01 1.00E00 1.00E00 oligosaccharide binding (GO:0070492) 17 0 .00 - < 0.01 1.00E00 1.00E00 endogalactosaminidase activity (GO:0033931) 1 0 .00 - < 0.01 1.00E00 1.00E00 Edg-2 lysophosphatidic acid receptor binding (GO:0031755) 2 0 .00 - < 0.01 1.00E00 1.00E00 endothelial differentiation G protein-coupled receptor binding (GO:0031753) 2 0 .00 - < 0.01 1.00E00 1.00E00 D5 dopamine receptor binding (GO:0031752) 2 0 .00 - < 0.01 1.00E00 1.00E00 D4 dopamine receptor binding (GO:0031751) 1 0 .00 - < 0.01 1.00E00 1.00E00 D3 dopamine receptor binding (GO:0031750) 2 0 .00 - < 0.01 1.00E00 1.00E00 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity (GO:0033925) 1 0 .00 - < 0.01 1.00E00 1.00E00 D2 dopamine receptor binding (GO:0031749) 3 0 .00 - < 0.01 1.00E00 1.00E00 D1 dopamine receptor binding (GO:0031748) 7 0 .00 - < 0.01 1.00E00 1.00E00 type B gastrin/cholecystokinin receptor binding (GO:0031741) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucan 1,3-alpha-glucosidase activity (GO:0033919) 1 0 .00 - < 0.01 1.00E00 1.00E00 cholecystokinin receptor binding (GO:0031739) 1 0 .00 - < 0.01 1.00E00 1.00E00 CX3C chemokine receptor binding (GO:0031737) 3 0 .00 - < 0.01 1.00E00 1.00E00 blue light photoreceptor activity (GO:0009882) 2 0 .00 - < 0.01 1.00E00 1.00E00 CCR10 chemokine receptor binding (GO:0031735) 3 0 .00 - < 0.01 1.00E00 1.00E00 photoreceptor activity (GO:0009881) 17 0 .00 - < 0.01 1.00E00 1.00E00 endoribonuclease inhibitor activity (GO:0060698) 2 0 .00 - < 0.01 1.00E00 1.00E00 CCR7 chemokine receptor binding (GO:0031732) 2 0 .00 - < 0.01 1.00E00 1.00E00 CCR6 chemokine receptor binding (GO:0031731) 10 0 .00 - < 0.01 1.00E00 1.00E00 CCR5 chemokine receptor binding (GO:0031730) 7 0 .00 - < 0.01 1.00E00 1.00E00 hyaluronoglucuronidase activity (GO:0033906) 2 0 .00 - < 0.01 1.00E00 1.00E00 estrogen 16-alpha-hydroxylase activity (GO:0101020) 9 0 .00 - < 0.01 1.00E00 1.00E00 tubulin-dependent ATPase activity (GO:0070463) 1 0 .00 - < 0.01 1.00E00 1.00E00 CCR4 chemokine receptor binding (GO:0031729) 1 0 .00 - < 0.01 1.00E00 1.00E00 antiporter activity (GO:0015297) 136 0 .04 - < 0.01 1.00E00 1.00E00 CCR3 chemokine receptor binding (GO:0031728) 5 0 .00 - < 0.01 1.00E00 1.00E00 monoatomic anion:monoatomic cation symporter activity (GO:0015296) 25 0 .01 - < 0.01 1.00E00 1.00E00 CCR2 chemokine receptor binding (GO:0031727) 5 0 .00 - < 0.01 1.00E00 1.00E00 solute:proton symporter activity (GO:0015295) 24 0 .01 - < 0.01 1.00E00 1.00E00 CCR1 chemokine receptor binding (GO:0031726) 6 0 .00 - < 0.01 1.00E00 1.00E00 solute:monoatomic cation symporter activity (GO:0015294) 116 0 .03 - < 0.01 1.00E00 1.00E00 symporter activity (GO:0015293) 146 0 .04 - < 0.01 1.00E00 1.00E00 CXCR5 chemokine receptor binding (GO:0031724) 1 0 .00 - < 0.01 1.00E00 1.00E00 uniporter activity (GO:0015292) 9 0 .00 - < 0.01 1.00E00 1.00E00 CXCR4 chemokine receptor binding (GO:0031723) 1 0 .00 - < 0.01 1.00E00 1.00E00 secondary active transmembrane transporter activity (GO:0015291) 288 0 .08 - < 0.01 1.00E00 1.00E00 hemoglobin alpha binding (GO:0031721) 5 0 .00 - < 0.01 1.00E00 1.00E00 haptoglobin binding (GO:0031720) 9 0 .00 - < 0.01 1.00E00 1.00E00 porin activity (GO:0015288) 6 0 .00 - < 0.01 1.00E00 1.00E00 type 1 cannabinoid receptor binding (GO:0031718) 1 0 .00 - < 0.01 1.00E00 1.00E00 cannabinoid receptor binding (GO:0031717) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcitonin receptor binding (GO:0031716) 2 0 .00 - < 0.01 1.00E00 1.00E00 C5L2 anaphylatoxin chemotactic receptor binding (GO:0031715) 1 0 .00 - < 0.01 1.00E00 1.00E00 C5a anaphylatoxin chemotactic receptor binding (GO:0031714) 1 0 .00 - < 0.01 1.00E00 1.00E00 ligand-gated sodium channel activity (GO:0015280) 18 0 .01 - < 0.01 1.00E00 1.00E00 bradykinin receptor binding (GO:0031711) 2 0 .00 - < 0.01 1.00E00 1.00E00 neuromedin B receptor binding (GO:0031710) 1 0 .00 - < 0.01 1.00E00 1.00E00 cobalt ion binding (GO:0050897) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein histidine phosphatase activity (GO:0101006) 1 0 .00 - < 0.01 1.00E00 1.00E00 deubiquitinase activity (GO:0101005) 116 0 .03 - < 0.01 1.00E00 1.00E00 store-operated calcium channel activity (GO:0015279) 10 0 .00 - < 0.01 1.00E00 1.00E00 intracellularly gated calcium channel activity (GO:0015278) 16 0 .00 - < 0.01 1.00E00 1.00E00 kainate selective glutamate receptor activity (GO:0015277) 5 0 .00 - < 0.01 1.00E00 1.00E00 endothelin B receptor binding (GO:0031708) 3 0 .00 - < 0.01 1.00E00 1.00E00 ligand-gated monoatomic ion channel activity (GO:0015276) 185 0 .05 - < 0.01 1.00E00 1.00E00 endothelin A receptor binding (GO:0031707) 1 0 .00 - < 0.01 1.00E00 1.00E00 stretch-activated, monoatomic cation-selective, calcium channel activity (GO:0015275) 3 0 .00 - < 0.01 1.00E00 1.00E00 bombesin receptor binding (GO:0031705) 4 0 .00 - < 0.01 1.00E00 1.00E00 sulfur compound transmembrane transporter activity (GO:1901682) 63 0 .02 - < 0.01 1.00E00 1.00E00 apelin receptor binding (GO:0031704) 2 0 .00 - < 0.01 1.00E00 1.00E00 sulfur compound binding (GO:1901681) 271 0 .08 - < 0.01 1.00E00 1.00E00 ATP-activated inward rectifier potassium channel activity (GO:0015272) 6 0 .00 - < 0.01 1.00E00 1.00E00 type 2 angiotensin receptor binding (GO:0031703) 2 0 .00 - < 0.01 1.00E00 1.00E00 outward rectifier potassium channel activity (GO:0015271) 25 0 .01 - < 0.01 1.00E00 1.00E00 type 1 angiotensin receptor binding (GO:0031702) 6 0 .00 - < 0.01 1.00E00 1.00E00 angiotensin receptor binding (GO:0031701) 9 0 .00 - < 0.01 1.00E00 1.00E00 adrenomedullin receptor binding (GO:0031700) 1 0 .00 - < 0.01 1.00E00 1.00E00 vitamin D binding (GO:0005499) 7 0 .00 - < 0.01 1.00E00 1.00E00 androgen binding (GO:0005497) 5 0 .00 - < 0.01 1.00E00 1.00E00 steroid binding (GO:0005496) 109 1 .03 + 31.47 3.14E-02 1.00E00 calcium-activated potassium channel activity (GO:0015269) 12 0 .00 - < 0.01 1.00E00 1.00E00 channel activity (GO:0015267) 508 0 .15 - < 0.01 1.00E00 1.00E00 urea channel activity (GO:0015265) 3 0 .00 - < 0.01 1.00E00 1.00E00 methylammonium channel activity (GO:0015264) 1 0 .00 - < 0.01 1.00E00 1.00E00 binding (GO:0005488) 16747 6 4.88 + 1.23 6.01E-01 1.00E00 intraciliary transport particle B binding (GO:0120170) 5 0 .00 - < 0.01 1.00E00 1.00E00 SNAP receptor activity (GO:0005484) 37 0 .01 - < 0.01 1.00E00 1.00E00 soluble NSF attachment protein activity (GO:0005483) 3 0 .00 - < 0.01 1.00E00 1.00E00 glycerol channel activity (GO:0015254) 6 0 .00 - < 0.01 1.00E00 1.00E00 proton channel activity (GO:0015252) 28 0 .01 - < 0.01 1.00E00 1.00E00 water channel activity (GO:0015250) 15 0 .00 - < 0.01 1.00E00 1.00E00 intraciliary transport particle A binding (GO:0120160) 3 0 .00 - < 0.01 1.00E00 1.00E00 pyruvate secondary active transmembrane transporter activity (GO:0005477) 1 0 .00 - < 0.01 1.00E00 1.00E00 carnitine:O-acyl-L-carnitine antiporter activity (GO:0005476) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATP:ADP antiporter activity (GO:0005471) 5 0 .00 - < 0.01 1.00E00 1.00E00 R-SMAD binding (GO:0070412) 26 0 .01 - < 0.01 1.00E00 1.00E00 I-SMAD binding (GO:0070411) 16 0 .00 - < 0.01 1.00E00 1.00E00 aminophospholipid flippase activity (GO:0015247) 7 0 .00 - < 0.01 1.00E00 1.00E00 co-SMAD binding (GO:0070410) 12 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid transmembrane transporter activity (GO:0015245) 19 0 .01 - < 0.01 1.00E00 1.00E00 calcium-dependent carbohydrate binding (GO:0120153) 1 0 .00 - < 0.01 1.00E00 1.00E00 UDP-xylose transmembrane transporter activity (GO:0005464) 1 0 .00 - < 0.01 1.00E00 1.00E00 UDP-N-acetylgalactosamine transmembrane transporter activity (GO:0005463) 2 0 .00 - < 0.01 1.00E00 1.00E00 UDP-N-acetylglucosamine transmembrane transporter activity (GO:0005462) 5 0 .00 - < 0.01 1.00E00 1.00E00 UDP-glucuronate transmembrane transporter activity (GO:0005461) 2 0 .00 - < 0.01 1.00E00 1.00E00 UDP-glucose transmembrane transporter activity (GO:0005460) 2 0 .00 - < 0.01 1.00E00 1.00E00 sphingolipid C4-monooxygenase activity (GO:0102772) 1 0 .00 - < 0.01 1.00E00 1.00E00 NADH binding (GO:0070404) 3 0 .00 - < 0.01 1.00E00 1.00E00 NAD+ binding (GO:0070403) 17 0 .00 - < 0.01 1.00E00 1.00E00 NADPH binding (GO:0070402) 17 0 .00 - < 0.01 1.00E00 1.00E00 thiamine transmembrane transporter activity (GO:0015234) 7 0 .00 - < 0.01 1.00E00 1.00E00 pantothenate transmembrane transporter activity (GO:0015233) 1 0 .00 - < 0.01 1.00E00 1.00E00 formylglycine-generating oxidase activity (GO:0120147) 1 0 .00 - < 0.01 1.00E00 1.00E00 heme transmembrane transporter activity (GO:0015232) 9 0 .00 - < 0.01 1.00E00 1.00E00 sulfatide binding (GO:0120146) 6 0 .00 - < 0.01 1.00E00 1.00E00 FAD transmembrane transporter activity (GO:0015230) 2 0 .00 - < 0.01 1.00E00 1.00E00 UDP-galactose transmembrane transporter activity (GO:0005459) 3 0 .00 - < 0.01 1.00E00 1.00E00 GDP-mannose transmembrane transporter activity (GO:0005458) 1 0 .00 - < 0.01 1.00E00 1.00E00 GDP-fucose transmembrane transporter activity (GO:0005457) 1 0 .00 - < 0.01 1.00E00 1.00E00 CMP-N-acetylneuraminate transmembrane transporter activity (GO:0005456) 1 0 .00 - < 0.01 1.00E00 1.00E00 solute:inorganic anion antiporter activity (GO:0005452) 33 0 .01 - < 0.01 1.00E00 1.00E00 extracellular matrix binding (GO:0050840) 67 0 .02 - < 0.01 1.00E00 1.00E00 basal RNA polymerase II transcription machinery binding (GO:0001099) 60 0 .02 - < 0.01 1.00E00 1.00E00 basal transcription machinery binding (GO:0001098) 60 0 .02 - < 0.01 1.00E00 1.00E00 TFIIH-class transcription factor complex binding (GO:0001097) 3 0 .00 - < 0.01 1.00E00 1.00E00 TFIIF-class transcription factor complex binding (GO:0001096) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-ascorbic acid transmembrane transporter activity (GO:0015229) 2 0 .00 - < 0.01 1.00E00 1.00E00 TFIID-class transcription factor complex binding (GO:0001094) 10 0 .00 - < 0.01 1.00E00 1.00E00 coenzyme A transmembrane transporter activity (GO:0015228) 3 0 .00 - < 0.01 1.00E00 1.00E00 TFIIB-class transcription factor binding (GO:0001093) 4 0 .00 - < 0.01 1.00E00 1.00E00 O-acyl-L-carnitine transmembrane transporter activity (GO:0015227) 1 0 .00 - < 0.01 1.00E00 1.00E00 carnitine transmembrane transporter activity (GO:0015226) 7 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II general transcription initiation factor binding (GO:0001091) 24 0 .01 - < 0.01 1.00E00 1.00E00 biotin transmembrane transporter activity (GO:0015225) 3 0 .00 - < 0.01 1.00E00 1.00E00 choline transmembrane transporter activity (GO:0015220) 9 0 .00 - < 0.01 1.00E00 1.00E00 protein folding chaperone (GO:0044183) 76 0 .02 - < 0.01 1.00E00 1.00E00 cell adhesion molecule binding (GO:0050839) 558 0 .16 - < 0.01 1.00E00 1.00E00 very-long-chain enoyl-CoA reductase activity (GO:0102758) 1 0 .00 - < 0.01 1.00E00 1.00E00 pyruvate transmembrane transporter activity (GO:0050833) 6 0 .00 - < 0.01 1.00E00 1.00E00 NADPH phosphatase activity (GO:0102757) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-1,3-galactosyltransferase activity (GO:0048531) 14 0 .00 - < 0.01 1.00E00 1.00E00 pyrimidine nucleotide transmembrane transporter activity (GO:0015218) 2 0 .00 - < 0.01 1.00E00 1.00E00 ADP transmembrane transporter activity (GO:0015217) 11 0 .00 - < 0.01 1.00E00 1.00E00 purine nucleotide transmembrane transporter activity (GO:0015216) 26 0 .01 - < 0.01 1.00E00 1.00E00 nucleotide transmembrane transporter activity (GO:0015215) 30 0 .01 - < 0.01 1.00E00 1.00E00 pyrimidine nucleoside transmembrane transporter activity (GO:0015214) 8 0 .00 - < 0.01 1.00E00 1.00E00 uridine transmembrane transporter activity (GO:0015213) 6 0 .00 - < 0.01 1.00E00 1.00E00 cytidine transmembrane transporter activity (GO:0015212) 4 0 .00 - < 0.01 1.00E00 1.00E00 purine nucleoside transmembrane transporter activity (GO:0015211) 4 0 .00 - < 0.01 1.00E00 1.00E00 uracil transmembrane transporter activity (GO:0015210) 3 0 .00 - < 0.01 1.00E00 1.00E00 sodium:phosphate symporter activity (GO:0005436) 12 0 .00 - < 0.01 1.00E00 1.00E00 calcium:sodium antiporter activity (GO:0005432) 9 0 .00 - < 0.01 1.00E00 1.00E00 guanine transmembrane transporter activity (GO:0015208) 4 0 .00 - < 0.01 1.00E00 1.00E00 adenine transmembrane transporter activity (GO:0015207) 5 0 .00 - < 0.01 1.00E00 1.00E00 nucleobase transmembrane transporter activity (GO:0015205) 11 0 .00 - < 0.01 1.00E00 1.00E00 cardiolipin binding (GO:1901612) 14 0 .00 - < 0.01 1.00E00 1.00E00 urea transmembrane transporter activity (GO:0015204) 8 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylglycerol binding (GO:1901611) 18 0 .01 - < 0.01 1.00E00 1.00E00 polyamine transmembrane transporter activity (GO:0015203) 10 0 .00 - < 0.01 1.00E00 1.00E00 methylammonium transmembrane transporter activity (GO:0015200) 2 0 .00 - < 0.01 1.00E00 1.00E00 proton-dependent oligopeptide secondary active transmembrane transporter activity (GO:0005427) 2 0 .00 - < 0.01 1.00E00 1.00E00 4-aminobutyrate:2-oxoglutarate transaminase activity (GO:0034386) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphothreonine residue binding (GO:0050816) 3 0 .00 - < 0.01 1.00E00 1.00E00 phosphoserine residue binding (GO:0050815) 10 0 .00 - < 0.01 1.00E00 1.00E00 GABA receptor binding (GO:0050811) 18 0 .01 - < 0.01 1.00E00 1.00E00 regulatory region RNA binding (GO:0001069) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity (GO:0102732) 1 0 .00 - < 0.01 1.00E00 1.00E00 transcription regulatory region nucleic acid binding (GO:0001067) 1443 0 .42 - < 0.01 1.00E00 1.00E00 ubiquitin-protein transferase activator activity (GO:0097027) 16 0 .00 - < 0.01 1.00E00 1.00E00 SMAD binding (GO:0046332) 79 0 .02 - < 0.01 1.00E00 1.00E00 DNA-3'-diphospho-5'-guanosine diphosphatase (GO:0120108) 1 0 .00 - < 0.01 1.00E00 1.00E00 fructose 6-phosphate aldolase activity (GO:0097023) 1 0 .00 - < 0.01 1.00E00 1.00E00 COPII receptor activity (GO:0097020) 2 0 .00 - < 0.01 1.00E00 1.00E00 amino acid:monoatomic cation symporter activity (GO:0005416) 29 0 .01 - < 0.01 1.00E00 1.00E00 nucleoside:sodium symporter activity (GO:0005415) 4 0 .00 - < 0.01 1.00E00 1.00E00 D-glucose:sodium symporter activity (GO:0005412) 6 0 .00 - < 0.01 1.00E00 1.00E00 acrosin binding (GO:0032190) 5 0 .00 - < 0.01 1.00E00 1.00E00 L27 domain binding (GO:0097016) 3 0 .00 - < 0.01 1.00E00 1.00E00 alpha-sialidase activity (GO:0016997) 4 0 .00 - < 0.01 1.00E00 1.00E00 lipoate synthase activity (GO:0016992) 1 0 .00 - < 0.01 1.00E00 1.00E00 carbohydrate:monoatomic cation symporter activity (GO:0005402) 15 0 .00 - < 0.01 1.00E00 1.00E00 SUMO polymer binding (GO:0032184) 6 0 .00 - < 0.01 1.00E00 1.00E00 SUMO binding (GO:0032183) 17 0 .00 - < 0.01 1.00E00 1.00E00 core promoter sequence-specific DNA binding (GO:0001046) 43 0 .01 - < 0.01 1.00E00 1.00E00 ubiquitin-like protein binding (GO:0032182) 121 0 .04 - < 0.01 1.00E00 1.00E00 dinucleotide repeat insertion binding (GO:0032181) 2 0 .00 - < 0.01 1.00E00 1.00E00 gluconokinase activity (GO:0046316) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase I core binding (GO:0001042) 4 0 .00 - < 0.01 1.00E00 1.00E00 adipokinetic hormone binding (GO:0097004) 2 0 .00 - < 0.01 1.00E00 1.00E00 adipokinetic hormone receptor activity (GO:0097003) 4 0 .00 - < 0.01 1.00E00 1.00E00 ceramide binding (GO:0097001) 19 0 .01 - < 0.01 1.00E00 1.00E00 mRNA 5'-diphosphatase activity (GO:0034353) 1 0 .00 - < 0.01 1.00E00 1.00E00 GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity (GO:0102704) 1 0 .00 - < 0.01 1.00E00 1.00E00 thiol oxidase activity (GO:0016972) 6 0 .00 - < 0.01 1.00E00 1.00E00 flavin-dependent sulfhydryl oxidase activity (GO:0016971) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein deglycase activity (GO:0036524) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase III general transcription initiation factor binding (GO:0001025) 3 0 .00 - < 0.01 1.00E00 1.00E00 alpha-2 macroglobulin receptor activity (GO:0016964) 1 0 .00 - < 0.01 1.00E00 1.00E00 short-chain carboxylesterase activity (GO:0034338) 6 0 .00 - < 0.01 1.00E00 1.00E00 DNA negative supercoiling activity (GO:0034335) 3 0 .00 - < 0.01 1.00E00 1.00E00 mitochondrial promoter sequence-specific DNA binding (GO:0001018) 2 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase III transcription regulatory region sequence-specific DNA binding (GO:0001016) 8 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity (GO:0001010) 1 0 .00 - < 0.01 1.00E00 1.00E00 mechanosensitive potassium channel activity (GO:0098782) 3 0 .00 - < 0.01 1.00E00 1.00E00 prosaposin receptor activity (GO:0036505) 2 0 .00 - < 0.01 1.00E00 1.00E00 vasoactive intestinal polypeptide receptor activity (GO:0004999) 3 0 .00 - < 0.01 1.00E00 1.00E00 transferrin receptor activity (GO:0004998) 2 0 .00 - < 0.01 1.00E00 1.00E00 thyrotropin-releasing hormone receptor activity (GO:0004997) 1 0 .00 - < 0.01 1.00E00 1.00E00 thyroid-stimulating hormone receptor activity (GO:0004996) 2 0 .00 - < 0.01 1.00E00 1.00E00 tachykinin receptor activity (GO:0004995) 3 0 .00 - < 0.01 1.00E00 1.00E00 somatostatin receptor activity (GO:0004994) 5 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled serotonin receptor activity (GO:0004993) 13 0 .00 - < 0.01 1.00E00 1.00E00 succinate-semialdehyde dehydrogenase binding (GO:0032145) 1 0 .00 - < 0.01 1.00E00 1.00E00 platelet activating factor receptor activity (GO:0004992) 3 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase III type 3 promoter sequence-specific DNA binding (GO:0001006) 6 0 .00 - < 0.01 1.00E00 1.00E00 parathyroid hormone receptor activity (GO:0004991) 2 0 .00 - < 0.01 1.00E00 1.00E00 single thymine insertion binding (GO:0032143) 2 0 .00 - < 0.01 1.00E00 1.00E00 oxytocin receptor activity (GO:0004990) 1 0 .00 - < 0.01 1.00E00 1.00E00 single guanine insertion binding (GO:0032142) 3 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase III type 2 promoter sequence-specific DNA binding (GO:0001003) 3 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase III type 1 promoter sequence-specific DNA binding (GO:0001002) 3 0 .00 - < 0.01 1.00E00 1.00E00 molecular function regulator activity (GO:0098772) 2270 0 .66 - < 0.01 1.00E00 1.00E00 natriuretic peptide receptor activity (GO:0016941) 3 0 .00 - < 0.01 1.00E00 1.00E00 FBXO family protein binding (GO:0098770) 2 0 .00 - < 0.01 1.00E00 1.00E00 nicotinate riboside kinase activity (GO:0034317) 2 0 .00 - < 0.01 1.00E00 1.00E00 dinucleotide insertion or deletion binding (GO:0032139) 3 0 .00 - < 0.01 1.00E00 1.00E00 single base insertion or deletion binding (GO:0032138) 4 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled opioid receptor activity (GO:0004985) 7 0 .00 - < 0.01 1.00E00 1.00E00 guanine/thymine mispair binding (GO:0032137) 3 0 .00 - < 0.01 1.00E00 1.00E00 olfactory receptor activity (GO:0004984) 438 0 .13 - < 0.01 1.00E00 1.00E00 neuropeptide Y receptor activity (GO:0004983) 10 0 .00 - < 0.01 1.00E00 1.00E00 DNA insertion or deletion binding (GO:0032135) 6 0 .00 - < 0.01 1.00E00 1.00E00 N-formyl peptide receptor activity (GO:0004982) 5 0 .00 - < 0.01 1.00E00 1.00E00 melanocyte-stimulating hormone receptor activity (GO:0004980) 3 0 .00 - < 0.01 1.00E00 1.00E00 3' overhang single-stranded DNA endodeoxyribonuclease activity (GO:1990599) 4 0 .00 - < 0.01 1.00E00 1.00E00 short-chain fatty acyl-CoA dehydrogenase activity (GO:0016937) 4 0 .00 - < 0.01 1.00E00 1.00E00 galactoside binding (GO:0016936) 7 0 .00 - < 0.01 1.00E00 1.00E00 mast cell secretagogue receptor activity (GO:1990595) 1 0 .00 - < 0.01 1.00E00 1.00E00 extracellularly glycine-gated chloride channel activity (GO:0016934) 4 0 .00 - < 0.01 1.00E00 1.00E00 extracellularly glycine-gated ion channel activity (GO:0016933) 4 0 .00 - < 0.01 1.00E00 1.00E00 BAT3 complex binding (GO:1904288) 4 0 .00 - < 0.01 1.00E00 1.00E00 beta-endorphin receptor activity (GO:0004979) 1 0 .00 - < 0.01 1.00E00 1.00E00 corticotropin receptor activity (GO:0004978) 1 0 .00 - < 0.01 1.00E00 1.00E00 melanocortin receptor activity (GO:0004977) 6 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K9 deacetylase activity, hydrolytic mechanism (GO:0032129) 11 0 .00 - < 0.01 1.00E00 1.00E00 leukotriene receptor activity (GO:0004974) 4 0 .00 - < 0.01 1.00E00 1.00E00 NMDA glutamate receptor activity (GO:0004972) 7 0 .00 - < 0.01 1.00E00 1.00E00 AMPA glutamate receptor activity (GO:0004971) 6 0 .00 - < 0.01 1.00E00 1.00E00 5S rRNA binding (GO:0008097) 9 0 .00 - < 0.01 1.00E00 1.00E00 glutamate-gated receptor activity (GO:0004970) 18 0 .01 - < 0.01 1.00E00 1.00E00 ATP-dependent activity, acting on DNA (GO:0008094) 120 0 .03 - < 0.01 1.00E00 1.00E00 cytoskeletal anchor activity (GO:0008093) 24 0 .01 - < 0.01 1.00E00 1.00E00 deSUMOylase activity (GO:0016929) 7 0 .00 - < 0.01 1.00E00 1.00E00 cytoskeletal protein binding (GO:0008092) 1002 0 .29 - < 0.01 1.00E00 1.00E00 phospholipase D activator activity (GO:1990583) 2 0 .00 - < 0.01 1.00E00 1.00E00 nuclear receptor binding (GO:0016922) 137 0 .04 - < 0.01 1.00E00 1.00E00 pyroglutamyl-peptidase activity (GO:0016920) 2 0 .00 - < 0.01 1.00E00 1.00E00 calcitriol binding (GO:1902098) 1 0 .00 - < 0.01 1.00E00 1.00E00 histamine receptor activity (GO:0004969) 6 0 .00 - < 0.01 1.00E00 1.00E00 gonadotropin-releasing hormone receptor activity (GO:0004968) 3 0 .00 - < 0.01 1.00E00 1.00E00 glucagon receptor activity (GO:0004967) 3 0 .00 - < 0.01 1.00E00 1.00E00 galanin receptor activity (GO:0004966) 4 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled GABA receptor activity (GO:0004965) 3 0 .00 - < 0.01 1.00E00 1.00E00 luteinizing hormone receptor activity (GO:0004964) 1 0 .00 - < 0.01 1.00E00 1.00E00 follicle-stimulating hormone receptor activity (GO:0004963) 1 0 .00 - < 0.01 1.00E00 1.00E00 double-stranded methylated DNA binding (GO:0010385) 6 0 .00 - < 0.01 1.00E00 1.00E00 endothelin receptor activity (GO:0004962) 3 0 .00 - < 0.01 1.00E00 1.00E00 thromboxane A2 receptor activity (GO:0004961) 1 0 .00 - < 0.01 1.00E00 1.00E00 thromboxane receptor activity (GO:0004960) 1 0 .00 - < 0.01 1.00E00 1.00E00 growth factor activity (GO:0008083) 162 0 .05 - < 0.01 1.00E00 1.00E00 retinal binding (GO:0016918) 19 0 .01 - < 0.01 1.00E00 1.00E00 phosphoric diester hydrolase activity (GO:0008081) 87 0 .03 - < 0.01 1.00E00 1.00E00 GABA receptor activity (GO:0016917) 23 0 .01 - < 0.01 1.00E00 1.00E00 N-acetyltransferase activity (GO:0008080) 67 0 .02 - < 0.01 1.00E00 1.00E00 follicle-stimulating hormone activity (GO:0016913) 2 0 .00 - < 0.01 1.00E00 1.00E00 prostaglandin F receptor activity (GO:0004958) 2 0 .00 - < 0.01 1.00E00 1.00E00 prostaglandin E receptor activity (GO:0004957) 5 0 .00 - < 0.01 1.00E00 1.00E00 prostaglandin D receptor activity (GO:0004956) 2 0 .00 - < 0.01 1.00E00 1.00E00 prostaglandin receptor activity (GO:0004955) 10 0 .00 - < 0.01 1.00E00 1.00E00 prostanoid receptor activity (GO:0004954) 11 0 .00 - < 0.01 1.00E00 1.00E00 icosanoid receptor activity (GO:0004953) 15 0 .00 - < 0.01 1.00E00 1.00E00 translation termination factor activity (GO:0008079) 7 0 .00 - < 0.01 1.00E00 1.00E00 dopamine neurotransmitter receptor activity (GO:0004952) 5 0 .00 - < 0.01 1.00E00 1.00E00 cholecystokinin receptor activity (GO:0004951) 2 0 .00 - < 0.01 1.00E00 1.00E00 chemokine receptor activity (GO:0004950) 26 0 .01 - < 0.01 1.00E00 1.00E00 ornithine decarboxylase inhibitor activity (GO:0008073) 3 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled acetylcholine receptor activity (GO:0016907) 5 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the aldehyde or oxo group of donors (GO:0016903) 46 0 .01 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor (GO:0016901) 2 0 .00 - < 0.01 1.00E00 1.00E00 NAD binding (GO:0051287) 54 0 .02 - < 0.01 1.00E00 1.00E00 P-type divalent copper transporter activity (GO:0043682) 2 0 .00 - < 0.01 1.00E00 1.00E00 cannabinoid receptor activity (GO:0004949) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K4 trimethyltransferase activity (GO:0140999) 10 0 .00 - < 0.01 1.00E00 1.00E00 calcitonin receptor activity (GO:0004948) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H2B kinase activity (GO:0140998) 244 0 .07 - < 0.01 1.00E00 1.00E00 bradykinin receptor activity (GO:0004947) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H4 kinase activity (GO:0140997) 244 0 .07 - < 0.01 1.00E00 1.00E00 bombesin receptor activity (GO:0004946) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H3 kinase activity (GO:0140996) 250 0 .07 - < 0.01 1.00E00 1.00E00 angiotensin type II receptor activity (GO:0004945) 4 0 .00 - < 0.01 1.00E00 1.00E00 histone H2A kinase activity (GO:0140995) 244 0 .07 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat modifying activity (GO:0140994) 127 0 .04 - < 0.01 1.00E00 1.00E00 histone modifying activity (GO:0140993) 555 0 .16 - < 0.01 1.00E00 1.00E00 extracellularly glutamate-gated chloride channel activity (GO:0008068) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta2-adrenergic receptor activity (GO:0004941) 2 0 .00 - < 0.01 1.00E00 1.00E00 beta1-adrenergic receptor activity (GO:0004940) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutamate receptor activity (GO:0008066) 26 0 .01 - < 0.01 1.00E00 1.00E00 chitin binding (GO:0008061) 8 0 .00 - < 0.01 1.00E00 1.00E00 beta-adrenergic receptor activity (GO:0004939) 4 0 .00 - < 0.01 1.00E00 1.00E00 alpha2-adrenergic receptor activity (GO:0004938) 3 0 .00 - < 0.01 1.00E00 1.00E00 ADP:phosphate antiporter activity (GO:0140988) 2 0 .00 - < 0.01 1.00E00 1.00E00 alpha1-adrenergic receptor activity (GO:0004937) 3 0 .00 - < 0.01 1.00E00 1.00E00 ATP:phosphate antiporter activity (GO:0140987) 3 0 .00 - < 0.01 1.00E00 1.00E00 alpha-adrenergic receptor activity (GO:0004936) 6 0 .00 - < 0.01 1.00E00 1.00E00 adrenergic receptor activity (GO:0004935) 10 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K12 methyltransferase activity (GO:0140984) 9 0 .00 - < 0.01 1.00E00 1.00E00 ribonuclease T2 activity (GO:0033897) 1 0 .00 - < 0.01 1.00E00 1.00E00 calcium:manganese antiporter activity (GO:0140983) 1 0 .00 - < 0.01 1.00E00 1.00E00 extracellularly ATP-gated monoatomic cation channel activity (GO:0004931) 7 0 .00 - < 0.01 1.00E00 1.00E00 medium-chain fatty acid omega-hydroxylase activity (GO:0140981) 1 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled receptor activity (GO:0004930) 880 0 .26 - < 0.01 1.00E00 1.00E00 CP2 mannose-ethanolamine phosphotransferase activity (GO:0051267) 1 0 .00 - < 0.01 1.00E00 1.00E00 diolein transacylation activity (GO:0051265) 3 0 .00 - < 0.01 1.00E00 1.00E00 mono-olein transacylation activity (GO:0051264) 3 0 .00 - < 0.01 1.00E00 1.00E00 mitochondrial large ribosomal subunit binding (GO:0140978) 4 0 .00 - < 0.01 1.00E00 1.00E00 lithium:proton antiporter activity (GO:0010348) 1 0 .00 - < 0.01 1.00E00 1.00E00 prolactin receptor activity (GO:0004925) 2 0 .00 - < 0.01 1.00E00 1.00E00 N-sulfoglucosamine-3-sulfatase activity (GO:0033889) 1 0 .00 - < 0.01 1.00E00 1.00E00 oncostatin-M receptor activity (GO:0004924) 3 0 .00 - < 0.01 1.00E00 1.00E00 leukemia inhibitory factor receptor activity (GO:0004923) 2 0 .00 - < 0.01 1.00E00 1.00E00 calcium sensitive guanylate cyclase activator activity (GO:0008048) 5 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-11 receptor activity (GO:0004921) 4 0 .00 - < 0.01 1.00E00 1.00E00 enzyme activator activity (GO:0008047) 636 0 .19 - < 0.01 1.00E00 1.00E00 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity (GO:0033885) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-10 receptor activity (GO:0004920) 2 0 .00 - < 0.01 1.00E00 1.00E00 axon guidance receptor activity (GO:0008046) 11 0 .00 - < 0.01 1.00E00 1.00E00 pyridoxal phosphatase activity (GO:0033883) 3 0 .00 - < 0.01 1.00E00 1.00E00 carboxyl-O-methyltransferase activity (GO:0010340) 6 0 .00 - < 0.01 1.00E00 1.00E00 choloyl-CoA hydrolase activity (GO:0033882) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-9 receptor activity (GO:0004919) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-8 receptor activity (GO:0004918) 2 0 .00 - < 0.01 1.00E00 1.00E00 polyspecific organic cation:proton antiporter activity (GO:0140968) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-7 receptor activity (GO:0004917) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-6 receptor activity (GO:0004915) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-5 receptor activity (GO:0004914) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-4 receptor activity (GO:0004913) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-3 receptor activity (GO:0004912) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-2 receptor activity (GO:0004911) 3 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-1, type II, blocking receptor activity (GO:0004910) 2 0 .00 - < 0.01 1.00E00 1.00E00 high-density lipoprotein particle binding (GO:0008035) 11 0 .00 - < 0.01 1.00E00 1.00E00 beta-3 adrenergic receptor binding (GO:0031699) 2 0 .00 - < 0.01 1.00E00 1.00E00 beta-2 adrenergic receptor binding (GO:0031698) 6 0 .00 - < 0.01 1.00E00 1.00E00 beta-1 adrenergic receptor binding (GO:0031697) 3 0 .00 - < 0.01 1.00E00 1.00E00 alpha-2C adrenergic receptor binding (GO:0031696) 2 0 .00 - < 0.01 1.00E00 1.00E00 alpha-2B adrenergic receptor binding (GO:0031695) 1 0 .00 - < 0.01 1.00E00 1.00E00 alpha-2A adrenergic receptor binding (GO:0031694) 5 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1B adrenergic receptor binding (GO:0031692) 1 0 .00 - < 0.01 1.00E00 1.00E00 adrenergic receptor binding (GO:0031690) 18 0 .01 - < 0.01 1.00E00 1.00E00 interleukin-1, type I, activating receptor activity (GO:0004909) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-1 receptor activity (GO:0004908) 7 0 .00 - < 0.01 1.00E00 1.00E00 type II interferon receptor activity (GO:0004906) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K79 trimethyltransferase activity (GO:0140956) 1 0 .00 - < 0.01 1.00E00 1.00E00 type I interferon receptor activity (GO:0004905) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K36 trimethyltransferase activity (GO:0140955) 6 0 .00 - < 0.01 1.00E00 1.00E00 interferon receptor activity (GO:0004904) 5 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K36 dimethyltransferase activity (GO:0140954) 4 0 .00 - < 0.01 1.00E00 1.00E00 growth hormone receptor activity (GO:0004903) 2 0 .00 - < 0.01 1.00E00 1.00E00 Fas-activated serine/threonine kinase activity (GO:0033867) 1 0 .00 - < 0.01 1.00E00 1.00E00 monocarboxylic acid transmembrane transporter activity (GO:0008028) 71 0 .02 - < 0.01 1.00E00 1.00E00 histone H3K27 dimethyltransferase activity (GO:0140952) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K27 trimethyltransferase activity (GO:0140951) 3 0 .00 - < 0.01 1.00E00 1.00E00 erythropoietin receptor activity (GO:0004900) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H2A deubiquitinase activity (GO:0140950) 6 0 .00 - < 0.01 1.00E00 1.00E00 UMP kinase activity (GO:0033862) 3 0 .00 - < 0.01 1.00E00 1.00E00 A2A adenosine receptor binding (GO:0031687) 3 0 .00 - < 0.01 1.00E00 1.00E00 single-stranded 3'-5' DNA helicase activity (GO:1990518) 47 0 .01 - < 0.01 1.00E00 1.00E00 A1 adenosine receptor binding (GO:0031686) 2 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled photoreceptor activity (GO:0008020) 15 0 .00 - < 0.01 1.00E00 1.00E00 adenosine receptor binding (GO:0031685) 7 0 .00 - < 0.01 1.00E00 1.00E00 G-protein beta/gamma-subunit complex binding (GO:0031683) 23 0 .01 - < 0.01 1.00E00 1.00E00 G-protein gamma-subunit binding (GO:0031682) 2 0 .00 - < 0.01 1.00E00 1.00E00 G-protein beta-subunit binding (GO:0031681) 23 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K9 trimethyltransferase activity (GO:0140949) 5 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K9 monomethyltransferase activity (GO:0140948) 6 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K9me2 methyltransferase activity (GO:0140947) 7 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K4 dimethyltransferase activity (GO:0140946) 1 0 .00 - < 0.01 1.00E00 1.00E00 citrate-L-glutamate ligase activity (GO:0072591) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K4 monomethyltransferase activity (GO:0140945) 8 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylgalactosamine kinase activity (GO:0033858) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetyl-L-aspartate-L-glutamate ligase activity (GO:0072590) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K20 monomethyltransferase activity (GO:0140944) 6 0 .00 - < 0.01 1.00E00 1.00E00 5-diphosphoinositol pentakisphosphate 1-kinase activity (GO:0033857) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K20 trimethyltransferase activity (GO:0140943) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-5-phosphate binding (GO:0010314) 21 0 .01 - < 0.01 1.00E00 1.00E00 microtubule binding (GO:0008017) 279 0 .08 - < 0.01 1.00E00 1.00E00 histone H4K20me methyltransferase activity (GO:0140941) 4 0 .00 - < 0.01 1.00E00 1.00E00 histone H2A methyltransferase activity (GO:0140940) 10 0 .00 - < 0.01 1.00E00 1.00E00 beta-catenin binding (GO:0008013) 107 0 .03 - < 0.01 1.00E00 1.00E00 histone H4 methyltransferase activity (GO:0140939) 21 0 .01 - < 0.01 1.00E00 1.00E00 histone H3 methyltransferase activity (GO:0140938) 47 0 .01 - < 0.01 1.00E00 1.00E00 acireductone dioxygenase [iron(II)-requiring] activity (GO:0010309) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H4K12 deacetylase activity, hydrolytic mechanism (GO:0140937) 11 0 .00 - < 0.01 1.00E00 1.00E00 acireductone dioxygenase (Ni2+-requiring) activity (GO:0010308) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H2B deubiquitinase activity (GO:0140936) 4 0 .00 - < 0.01 1.00E00 1.00E00 histone deubiquitinase activity (GO:0140934) 8 0 .00 - < 0.01 1.00E00 1.00E00 chemokine activity (GO:0008009) 48 0 .01 - < 0.01 1.00E00 1.00E00 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity (GO:0140933) 5 0 .00 - < 0.01 1.00E00 1.00E00 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity (GO:0140932) 2 0 .00 - < 0.01 1.00E00 1.00E00 neutral L-amino acid:sodium:chloride symporter activity (GO:0140931) 1 0 .00 - < 0.01 1.00E00 1.00E00 fructose:sodium symporter activity (GO:0140930) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity (GO:0033842) 2 0 .00 - < 0.01 1.00E00 1.00E00 alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity (GO:0033840) 3 0 .00 - < 0.01 1.00E00 1.00E00 phosphoprotein binding (GO:0051219) 93 0 .03 - < 0.01 1.00E00 1.00E00 dioxygenase activity (GO:0051213) 93 0 .03 - < 0.01 1.00E00 1.00E00 mannose:sodium symporter activity (GO:0140929) 1 0 .00 - < 0.01 1.00E00 1.00E00 poly-ADP-D-ribose binding (GO:0072572) 7 0 .00 - < 0.01 1.00E00 1.00E00 L-kynurenine transmembrane transporter activity (GO:0140926) 1 0 .00 - < 0.01 1.00E00 1.00E00 mono-ADP-D-ribose binding (GO:0072571) 1 0 .00 - < 0.01 1.00E00 1.00E00 ADP-D-ribose binding (GO:0072570) 3 0 .00 - < 0.01 1.00E00 1.00E00 aspartate:glutamate, proton antiporter activity (GO:0000515) 2 0 .00 - < 0.01 1.00E00 1.00E00 3-sulfino-L-alanine: proton, glutamate antiporter activity (GO:0000514) 2 0 .00 - < 0.01 1.00E00 1.00E00 H2A-H2B histone complex chaperone activity (GO:0000511) 1 0 .00 - < 0.01 1.00E00 1.00E00 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity (GO:0033829) 3 0 .00 - < 0.01 1.00E00 1.00E00 membrane destabilizing activity (GO:0140912) 3 0 .00 - < 0.01 1.00E00 1.00E00 pore-forming activity (GO:0140911) 3 0 .00 - < 0.01 1.00E00 1.00E00 procollagen glucosyltransferase activity (GO:0033823) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K122 acetyltransferase activity (GO:0140908) 20 0 .01 - < 0.01 1.00E00 1.00E00 halogenase activity (GO:0140906) 1 0 .00 - < 0.01 1.00E00 1.00E00 lipoyl(octanoyl) transferase activity (GO:0033819) 1 0 .00 - < 0.01 1.00E00 1.00E00 haloperoxidase activity (GO:0140905) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3R26 methyltransferase activity (GO:0140903) 8 0 .00 - < 0.01 1.00E00 1.00E00 L-glutamine:sodium symporter activity (GO:0140902) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-asparagine:sodium symporter activity (GO:0140901) 1 0 .00 - < 0.01 1.00E00 1.00E00 propanoyl-CoA C-acyltransferase activity (GO:0033814) 1 0 .00 - < 0.01 1.00E00 1.00E00 chloride:bicarbonate antiporter activity (GO:0140900) 12 0 .00 - < 0.01 1.00E00 1.00E00 ATPase regulator activity (GO:0060590) 50 0 .01 - < 0.01 1.00E00 1.00E00 L-cysteine desulfhydrase activity (GO:0080146) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-tyrosine binding (GO:0072545) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-DOPA binding (GO:0072544) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein phosphatase activator activity (GO:0072542) 24 0 .01 - < 0.01 1.00E00 1.00E00 peroxynitrite reductase activity (GO:0072541) 1 0 .00 - < 0.01 1.00E00 1.00E00 amino-acid betaine transmembrane transporter activity (GO:0015199) 4 0 .00 - < 0.01 1.00E00 1.00E00 opioid receptor binding (GO:0031628) 7 0 .00 - < 0.01 1.00E00 1.00E00 L-tryptophan transmembrane transporter activity (GO:0015196) 3 0 .00 - < 0.01 1.00E00 1.00E00 L-threonine transmembrane transporter activity (GO:0015195) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-serine transmembrane transporter activity (GO:0015194) 9 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin protein ligase binding (GO:0031625) 301 0 .09 - < 0.01 1.00E00 1.00E00 nucleoside-triphosphatase regulator activity (GO:0060589) 493 0 .14 - < 0.01 1.00E00 1.00E00 L-proline transmembrane transporter activity (GO:0015193) 7 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin conjugating enzyme binding (GO:0031624) 30 0 .01 - < 0.01 1.00E00 1.00E00 L-phenylalanine transmembrane transporter activity (GO:0015192) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-methionine transmembrane transporter activity (GO:0015191) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-leucine transmembrane transporter activity (GO:0015190) 6 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid 2-hydroxylase activity (GO:0080132) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-lysine transmembrane transporter activity (GO:0015189) 9 0 .00 - < 0.01 1.00E00 1.00E00 L-isoleucine transmembrane transporter activity (GO:0015188) 3 0 .00 - < 0.01 1.00E00 1.00E00 glycine transmembrane transporter activity (GO:0015187) 10 0 .00 - < 0.01 1.00E00 1.00E00 L-glutamine transmembrane transporter activity (GO:0015186) 9 0 .00 - < 0.01 1.00E00 1.00E00 gamma-aminobutyric acid transmembrane transporter activity (GO:0015185) 9 0 .00 - < 0.01 1.00E00 1.00E00 L-cystine transmembrane transporter activity (GO:0015184) 4 0 .00 - < 0.01 1.00E00 1.00E00 L-aspartate transmembrane transporter activity (GO:0015183) 9 0 .00 - < 0.01 1.00E00 1.00E00 L-asparagine transmembrane transporter activity (GO:0015182) 4 0 .00 - < 0.01 1.00E00 1.00E00 L-alanine transmembrane transporter activity (GO:0015180) 9 0 .00 - < 0.01 1.00E00 1.00E00 crotonyl-CoA hydratase activity (GO:0120092) 2 0 .00 - < 0.01 1.00E00 1.00E00 AMP transmembrane transporter activity (GO:0080122) 2 0 .00 - < 0.01 1.00E00 1.00E00 toxin transmembrane transporter activity (GO:0019534) 8 0 .00 - < 0.01 1.00E00 1.00E00 oxalate transmembrane transporter activity (GO:0019531) 10 0 .00 - < 0.01 1.00E00 1.00E00 Roundabout binding (GO:0048495) 6 0 .00 - < 0.01 1.00E00 1.00E00 gap junction channel activity involved in cell communication by electrical coupling (GO:1903763) 7 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of postsynapse (GO:0099186) 23 0 .01 - < 0.01 1.00E00 1.00E00 structural constituent of postsynaptic intermediate filament cytoskeleton (GO:0099184) 3 0 .00 - < 0.01 1.00E00 1.00E00 L-amino acid transmembrane transporter activity (GO:0015179) 62 0 .02 - < 0.01 1.00E00 1.00E00 structural constituent of presynapse (GO:0099181) 1 0 .00 - < 0.01 1.00E00 1.00E00 neutral L-amino acid transmembrane transporter activity (GO:0015175) 41 0 .01 - < 0.01 1.00E00 1.00E00 basic amino acid transmembrane transporter activity (GO:0015174) 21 0 .01 - < 0.01 1.00E00 1.00E00 aromatic amino acid transmembrane transporter activity (GO:0015173) 11 0 .00 - < 0.01 1.00E00 1.00E00 acidic amino acid transmembrane transporter activity (GO:0015172) 18 0 .01 - < 0.01 1.00E00 1.00E00 amino acid transmembrane transporter activity (GO:0015171) 102 0 .03 - < 0.01 1.00E00 1.00E00 Rho-dependent protein serine/threonine kinase activity (GO:0072518) 244 0 .07 - < 0.01 1.00E00 1.00E00 P-type sodium:potassium-exchanging transporter activity (GO:0005391) 7 0 .00 - < 0.01 1.00E00 1.00E00 RAGE receptor binding (GO:0050786) 11 0 .00 - < 0.01 1.00E00 1.00E00 advanced glycation end-product receptor activity (GO:0050785) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta-tubulin binding (GO:0048487) 42 0 .01 - < 0.01 1.00E00 1.00E00 dopamine receptor binding (GO:0050780) 15 0 .00 - < 0.01 1.00E00 1.00E00 3'-flap-structured DNA binding (GO:0070337) 1 0 .00 - < 0.01 1.00E00 1.00E00 flap-structured DNA binding (GO:0070336) 2 0 .00 - < 0.01 1.00E00 1.00E00 aspartate binding (GO:0070335) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycerol transmembrane transporter activity (GO:0015168) 8 0 .00 - < 0.01 1.00E00 1.00E00 polyol transmembrane transporter activity (GO:0015166) 12 0 .00 - < 0.01 1.00E00 1.00E00 pyrimidine nucleotide-sugar transmembrane transporter activity (GO:0015165) 11 0 .00 - < 0.01 1.00E00 1.00E00 glucuronoside transmembrane transporter activity (GO:0015164) 1 0 .00 - < 0.01 1.00E00 1.00E00 P-type calcium transporter activity (GO:0005388) 9 0 .00 - < 0.01 1.00E00 1.00E00 zinc ion transmembrane transporter activity (GO:0005385) 26 0 .01 - < 0.01 1.00E00 1.00E00 manganese ion transmembrane transporter activity (GO:0005384) 9 0 .00 - < 0.01 1.00E00 1.00E00 iron ion transmembrane transporter activity (GO:0005381) 10 0 .00 - < 0.01 1.00E00 1.00E00 very-low-density lipoprotein particle receptor binding (GO:0070326) 4 0 .00 - < 0.01 1.00E00 1.00E00 lipoprotein particle receptor binding (GO:0070325) 31 0 .01 - < 0.01 1.00E00 1.00E00 thyroid hormone binding (GO:0070324) 5 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid derivative binding (GO:1901567) 16 0 .00 - < 0.01 1.00E00 1.00E00 oligosaccharide transmembrane transporter activity (GO:0015157) 4 0 .00 - < 0.01 1.00E00 1.00E00 inward rectifier potassium channel inhibitor activity (GO:0070320) 1 0 .00 - < 0.01 1.00E00 1.00E00 disaccharide transmembrane transporter activity (GO:0015154) 4 0 .00 - < 0.01 1.00E00 1.00E00 glucose-6-phosphate transmembrane transporter activity (GO:0015152) 3 0 .00 - < 0.01 1.00E00 1.00E00 alpha-glucoside transmembrane transporter activity (GO:0015151) 2 0 .00 - < 0.01 1.00E00 1.00E00 fucose transmembrane transporter activity (GO:0015150) 3 0 .00 - < 0.01 1.00E00 1.00E00 copper ion transmembrane transporter activity (GO:0005375) 7 0 .00 - < 0.01 1.00E00 1.00E00 water transmembrane transporter activity (GO:0005372) 18 0 .01 - < 0.01 1.00E00 1.00E00 tricarboxylate secondary active transmembrane transporter activity (GO:0005371) 1 0 .00 - < 0.01 1.00E00 1.00E00 hexose transmembrane transporter activity (GO:0015149) 22 0 .01 - < 0.01 1.00E00 1.00E00 pentose transmembrane transporter activity (GO:0015146) 2 0 .00 - < 0.01 1.00E00 1.00E00 monosaccharide transmembrane transporter activity (GO:0015145) 24 0 .01 - < 0.01 1.00E00 1.00E00 carbohydrate transmembrane transporter activity (GO:0015144) 38 0 .01 - < 0.01 1.00E00 1.00E00 urate transmembrane transporter activity (GO:0015143) 9 0 .00 - < 0.01 1.00E00 1.00E00 tricarboxylic acid transmembrane transporter activity (GO:0015142) 4 0 .00 - < 0.01 1.00E00 1.00E00 succinate transmembrane transporter activity (GO:0015141) 5 0 .00 - < 0.01 1.00E00 1.00E00 malate transmembrane transporter activity (GO:0015140) 3 0 .00 - < 0.01 1.00E00 1.00E00 ribitol beta-1,4-xylosyltransferase activity (GO:0120053) 1 0 .00 - < 0.01 1.00E00 1.00E00 taurine:sodium symporter activity (GO:0005369) 3 0 .00 - < 0.01 1.00E00 1.00E00 taurine transmembrane transporter activity (GO:0005368) 5 0 .00 - < 0.01 1.00E00 1.00E00 myo-inositol:sodium symporter activity (GO:0005367) 2 0 .00 - < 0.01 1.00E00 1.00E00 myo-inositol:proton symporter activity (GO:0005366) 1 0 .00 - < 0.01 1.00E00 1.00E00 myo-inositol transmembrane transporter activity (GO:0005365) 4 0 .00 - < 0.01 1.00E00 1.00E00 low-affinity D-glucose:sodium symporter activity (GO:0005362) 2 0 .00 - < 0.01 1.00E00 1.00E00 low-density lipoprotein particle receptor binding (GO:0050750) 26 0 .01 - < 0.01 1.00E00 1.00E00 fatty aldehyde dehydrogenase (NAD+) activity (GO:0102673) 3 0 .00 - < 0.01 1.00E00 1.00E00 alpha-ketoglutarate transmembrane transporter activity (GO:0015139) 6 0 .00 - < 0.01 1.00E00 1.00E00 fumarate transmembrane transporter activity (GO:0015138) 1 0 .00 - < 0.01 1.00E00 1.00E00 intracellularly ATP-gated ion channel activity (GO:0099142) 1 0 .00 - < 0.01 1.00E00 1.00E00 citrate transmembrane transporter activity (GO:0015137) 4 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidic acid binding (GO:0070300) 24 0 .01 - < 0.01 1.00E00 1.00E00 sialic acid transmembrane transporter activity (GO:0015136) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucuronate transmembrane transporter activity (GO:0015135) 1 0 .00 - < 0.01 1.00E00 1.00E00 U6 snRNA (adenine-(43)-N(6))-methyltransferase activity (GO:0120048) 1 0 .00 - < 0.01 1.00E00 1.00E00 prostaglandin transmembrane transporter activity (GO:0015132) 12 0 .00 - < 0.01 1.00E00 1.00E00 oxaloacetate transmembrane transporter activity (GO:0015131) 2 0 .00 - < 0.01 1.00E00 1.00E00 mevalonate transmembrane transporter activity (GO:0015130) 1 0 .00 - < 0.01 1.00E00 1.00E00 dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity (GO:0052926) 1 0 .00 - < 0.01 1.00E00 1.00E00 dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity (GO:0052925) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-glucose:proton symporter activity (GO:0005356) 2 0 .00 - < 0.01 1.00E00 1.00E00 all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity (GO:0052923) 2 0 .00 - < 0.01 1.00E00 1.00E00 galactose transmembrane transporter activity (GO:0005354) 4 0 .00 - < 0.01 1.00E00 1.00E00 fructose transmembrane transporter activity (GO:0005353) 8 0 .00 - < 0.01 1.00E00 1.00E00 carbohydrate:proton symporter activity (GO:0005351) 7 0 .00 - < 0.01 1.00E00 1.00E00 pyrimidine nucleobase transmembrane transporter activity (GO:0005350) 7 0 .00 - < 0.01 1.00E00 1.00E00 lactate transmembrane transporter activity (GO:0015129) 6 0 .00 - < 0.01 1.00E00 1.00E00 bilirubin transmembrane transporter activity (GO:0015127) 1 0 .00 - < 0.01 1.00E00 1.00E00 canalicular bile acid transmembrane transporter activity (GO:0015126) 1 0 .00 - < 0.01 1.00E00 1.00E00 estrogen binding (GO:0099130) 1 0 .00 - < 0.01 1.00E00 1.00E00 bile acid transmembrane transporter activity (GO:0015125) 21 0 .01 - < 0.01 1.00E00 1.00E00 nitric-oxide synthase inhibitor activity (GO:0036487) 2 0 .00 - < 0.01 1.00E00 1.00E00 dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity (GO:0052918) 1 0 .00 - < 0.01 1.00E00 1.00E00 dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase (GO:0052917) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATP transmembrane transporter activity (GO:0005347) 14 0 .00 - < 0.01 1.00E00 1.00E00 purine ribonucleotide transmembrane transporter activity (GO:0005346) 19 0 .01 - < 0.01 1.00E00 1.00E00 purine nucleobase transmembrane transporter activity (GO:0005345) 10 0 .00 - < 0.01 1.00E00 1.00E00 oxygen carrier activity (GO:0005344) 13 0 .00 - < 0.01 1.00E00 1.00E00 organic acid:sodium symporter activity (GO:0005343) 35 0 .01 - < 0.01 1.00E00 1.00E00 organic acid transmembrane transporter activity (GO:0005342) 190 0 .06 - < 0.01 1.00E00 1.00E00 RS domain binding (GO:0050733) 5 0 .00 - < 0.01 1.00E00 1.00E00 hexose phosphate transmembrane transporter activity (GO:0015119) 3 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II C-terminal domain binding (GO:0099122) 10 0 .00 - < 0.01 1.00E00 1.00E00 thiosulfate transmembrane transporter activity (GO:0015117) 1 0 .00 - < 0.01 1.00E00 1.00E00 sulfate transmembrane transporter activity (GO:0015116) 15 0 .00 - < 0.01 1.00E00 1.00E00 nitrate transmembrane transporter activity (GO:0015112) 1 0 .00 - < 0.01 1.00E00 1.00E00 iodide transmembrane transporter activity (GO:0015111) 6 0 .00 - < 0.01 1.00E00 1.00E00 peroxidase inhibitor activity (GO:0036479) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-dopa decarboxylase activator activity (GO:0036478) 1 0 .00 - < 0.01 1.00E00 1.00E00 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity (GO:0052909) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucagon family peptide binding (GO:0120022) 1 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol transfer activity (GO:0120020) 25 0 .01 - < 0.01 1.00E00 1.00E00 nucleotide-sugar transmembrane transporter activity (GO:0005338) 13 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (guanine(37)-N1)-methyltransferase activity (GO:0052906) 1 0 .00 - < 0.01 1.00E00 1.00E00 nucleoside transmembrane transporter activity (GO:0005337) 10 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (guanosine(9)-N1)-methyltransferase activity (GO:0052905) 3 0 .00 - < 0.01 1.00E00 1.00E00 serotonin:sodium:chloride symporter activity (GO:0005335) 3 0 .00 - < 0.01 1.00E00 1.00E00 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity (GO:0052903) 1 0 .00 - < 0.01 1.00E00 1.00E00 norepinephrine:sodium symporter activity (GO:0005334) 3 0 .00 - < 0.01 1.00E00 1.00E00 tyrosine 3-monooxygenase activator activity (GO:0036470) 1 0 .00 - < 0.01 1.00E00 1.00E00 spermine oxidase activity (GO:0052901) 1 0 .00 - < 0.01 1.00E00 1.00E00 gamma-aminobutyric acid:sodium:chloride symporter activity (GO:0005332) 6 0 .00 - < 0.01 1.00E00 1.00E00 dopamine:sodium symporter activity (GO:0005330) 3 0 .00 - < 0.01 1.00E00 1.00E00 chloride transmembrane transporter activity (GO:0015108) 120 0 .03 - < 0.01 1.00E00 1.00E00 bicarbonate transmembrane transporter activity (GO:0015106) 32 0 .01 - < 0.01 1.00E00 1.00E00 phosphatidylcholine transfer activity (GO:0120019) 6 0 .00 - < 0.01 1.00E00 1.00E00 arsenite transmembrane transporter activity (GO:0015105) 1 0 .00 - < 0.01 1.00E00 1.00E00 ceramide transfer activity (GO:0120017) 8 0 .00 - < 0.01 1.00E00 1.00E00 inorganic anion transmembrane transporter activity (GO:0015103) 164 0 .05 - < 0.01 1.00E00 1.00E00 sphingolipid transfer activity (GO:0120016) 9 0 .00 - < 0.01 1.00E00 1.00E00 sterol transfer activity (GO:0120015) 32 0 .01 - < 0.01 1.00E00 1.00E00 organic cation transmembrane transporter activity (GO:0015101) 82 0 .02 - < 0.01 1.00E00 1.00E00 phospholipid transfer activity (GO:0120014) 26 0 .01 - < 0.01 1.00E00 1.00E00 vanadium ion transmembrane transporter activity (GO:0015100) 1 0 .00 - < 0.01 1.00E00 1.00E00 lipid transfer activity (GO:0120013) 65 0 .02 - < 0.01 1.00E00 1.00E00 L-dopa decarboxylase activity (GO:0036468) 1 0 .00 - < 0.01 1.00E00 1.00E00 5-hydroxy-L-tryptophan decarboxylase activity (GO:0036467) 1 0 .00 - < 0.01 1.00E00 1.00E00 neurotransmitter:sodium symporter activity (GO:0005328) 1 0 .00 - < 0.01 1.00E00 1.00E00 neurotransmitter transmembrane transporter activity (GO:0005326) 20 0 .01 - < 0.01 1.00E00 1.00E00 TRAIL receptor activity (GO:0036463) 1 0 .00 - < 0.01 1.00E00 1.00E00 long-chain fatty acid transmembrane transporter activity (GO:0005324) 16 0 .00 - < 0.01 1.00E00 1.00E00 BLOC-2 complex binding (GO:0036461) 2 0 .00 - < 0.01 1.00E00 1.00E00 ion channel regulator activity (GO:0099106) 160 0 .05 - < 0.01 1.00E00 1.00E00 potassium channel activator activity (GO:0099104) 7 0 .00 - < 0.01 1.00E00 1.00E00 channel activator activity (GO:0099103) 10 0 .00 - < 0.01 1.00E00 1.00E00 carbohydrate derivative transmembrane transporter activity (GO:1901505) 53 0 .02 - < 0.01 1.00E00 1.00E00 hepatocyte growth factor binding (GO:0036458) 1 0 .00 - < 0.01 1.00E00 1.00E00 lipid transporter activity (GO:0005319) 182 0 .05 - < 0.01 1.00E00 1.00E00 L-methionine-(S)-S-oxide reductase activity (GO:0036456) 1 0 .00 - < 0.01 1.00E00 1.00E00 high-affinity phosphate:sodium symporter activity (GO:0005316) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphate transmembrane transporter activity (GO:0005315) 24 0 .01 - < 0.01 1.00E00 1.00E00 high-affinity L-glutamate transmembrane transporter activity (GO:0005314) 5 0 .00 - < 0.01 1.00E00 1.00E00 L-glutamate transmembrane transporter activity (GO:0005313) 14 0 .00 - < 0.01 1.00E00 1.00E00 dicarboxylic acid transmembrane transporter activity (GO:0005310) 31 0 .01 - < 0.01 1.00E00 1.00E00 epidermal growth factor binding (GO:0048408) 4 0 .00 - < 0.01 1.00E00 1.00E00 platelet-derived growth factor binding (GO:0048407) 11 0 .00 - < 0.01 1.00E00 1.00E00 nerve growth factor binding (GO:0048406) 6 0 .00 - < 0.01 1.00E00 1.00E00 CARD domain binding (GO:0050700) 15 0 .00 - < 0.01 1.00E00 1.00E00 brain-derived neurotrophic factor binding (GO:0048403) 4 0 .00 - < 0.01 1.00E00 1.00E00 SAM domain binding (GO:0032093) 2 0 .00 - < 0.01 1.00E00 1.00E00 Pyrin domain binding (GO:0032090) 2 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor (GO:0016899) 3 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor (GO:0016898) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA exonuclease activity, producing 5'-phosphomonoesters (GO:0016896) 39 0 .01 - < 0.01 1.00E00 1.00E00 DNA exonuclease activity, producing 5'-phosphomonoesters (GO:0016895) 26 0 .01 - < 0.01 1.00E00 1.00E00 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters (GO:0016894) 17 0 .00 - < 0.01 1.00E00 1.00E00 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters (GO:0016893) 48 0 .01 - < 0.01 1.00E00 1.00E00 RNA endonuclease activity, producing 3'-phosphomonoesters (GO:0016892) 7 0 .00 - < 0.01 1.00E00 1.00E00 RNA endonuclease activity, producing 5'-phosphomonoesters (GO:0016891) 38 0 .01 - < 0.01 1.00E00 1.00E00 site-specific endodeoxyribonuclease activity, specific for altered base (GO:0016890) 2 0 .00 - < 0.01 1.00E00 1.00E00 creatine:sodium symporter activity (GO:0005309) 1 0 .00 - < 0.01 1.00E00 1.00E00 creatine transmembrane transporter activity (GO:0005308) 4 0 .00 - < 0.01 1.00E00 1.00E00 choline:sodium symporter activity (GO:0005307) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-valine transmembrane transporter activity (GO:0005304) 1 0 .00 - < 0.01 1.00E00 1.00E00 citrate synthase activity (GO:0036440) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-tyrosine transmembrane transporter activity (GO:0005302) 1 0 .00 - < 0.01 1.00E00 1.00E00 NACHT domain binding (GO:0032089) 2 0 .00 - < 0.01 1.00E00 1.00E00 DNA endonuclease activity, producing 3'-phosphomonoesters (GO:0016889) 9 0 .00 - < 0.01 1.00E00 1.00E00 endodeoxyribonuclease activity, producing 5'-phosphomonoesters (GO:0016888) 15 0 .00 - < 0.01 1.00E00 1.00E00 ATP hydrolysis activity (GO:0016887) 419 0 .12 - < 0.01 1.00E00 1.00E00 ligase activity, forming phosphoric ester bonds (GO:0016886) 8 0 .00 - < 0.01 1.00E00 1.00E00 ligase activity, forming carbon-carbon bonds (GO:0016885) 7 0 .00 - < 0.01 1.00E00 1.00E00 carbon-nitrogen ligase activity, with glutamine as amido-N-donor (GO:0016884) 10 0 .00 - < 0.01 1.00E00 1.00E00 cyclo-ligase activity (GO:0016882) 2 0 .00 - < 0.01 1.00E00 1.00E00 acid-amino acid ligase activity (GO:0016881) 22 0 .01 - < 0.01 1.00E00 1.00E00 acid-ammonia (or amide) ligase activity (GO:0016880) 2 0 .00 - < 0.01 1.00E00 1.00E00 K48-linked polyubiquitin modification-dependent protein binding (GO:0036435) 10 0 .00 - < 0.01 1.00E00 1.00E00 dCMP kinase activity (GO:0036431) 4 0 .00 - < 0.01 1.00E00 1.00E00 CMP kinase activity (GO:0036430) 4 0 .00 - < 0.01 1.00E00 1.00E00 ligase activity, forming carbon-nitrogen bonds (GO:0016879) 48 0 .01 - < 0.01 1.00E00 1.00E00 acid-thiol ligase activity (GO:0016878) 31 0 .01 - < 0.01 1.00E00 1.00E00 ligase activity, forming carbon-sulfur bonds (GO:0016877) 41 0 .01 - < 0.01 1.00E00 1.00E00 ligase activity, forming carbon-oxygen bonds (GO:0016875) 41 0 .01 - < 0.01 1.00E00 1.00E00 ligase activity (GO:0016874) 167 0 .05 - < 0.01 1.00E00 1.00E00 histone H2BS14 kinase activity (GO:0044025) 244 0 .07 - < 0.01 1.00E00 1.00E00 intramolecular lyase activity (GO:0016872) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AS1 kinase activity (GO:0044024) 244 0 .07 - < 0.01 1.00E00 1.00E00 histone H4S1 kinase activity (GO:0044023) 244 0 .07 - < 0.01 1.00E00 1.00E00 histone H3S28 kinase activity (GO:0044022) 244 0 .07 - < 0.01 1.00E00 1.00E00 histone H4R3 methyltransferase activity (GO:0044020) 10 0 .00 - < 0.01 1.00E00 1.00E00 L-phosphoserine phosphatase activity (GO:0036424) 1 0 .00 - < 0.01 1.00E00 1.00E00 mitochondrial transcription factor activity (GO:0034246) 4 0 .00 - < 0.01 1.00E00 1.00E00 intramolecular aminotransferase activity (GO:0016869) 1 0 .00 - < 0.01 1.00E00 1.00E00 intramolecular phosphotransferase activity (GO:0016868) 10 0 .00 - < 0.01 1.00E00 1.00E00 intramolecular transferase activity (GO:0016866) 28 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K36 acetyltransferase activity (GO:0044018) 20 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K27 acetyltransferase activity (GO:0044017) 20 0 .01 - < 0.01 1.00E00 1.00E00 intramolecular oxidoreductase activity, transposing S-S bonds (GO:0016864) 18 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K4 acetyltransferase activity (GO:0044016) 20 0 .01 - < 0.01 1.00E00 1.00E00 inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels (GO:0098695) 1 0 .00 - < 0.01 1.00E00 1.00E00 intramolecular oxidoreductase activity, transposing C=C bonds (GO:0016863) 15 0 .00 - < 0.01 1.00E00 1.00E00 histone H2BK12 acetyltransferase activity (GO:0044015) 20 0 .01 - < 0.01 1.00E00 1.00E00 intramolecular oxidoreductase activity, interconverting keto- and enol-groups (GO:0016862) 7 0 .00 - < 0.01 1.00E00 1.00E00 histone H2BK5 acetyltransferase activity (GO:0044014) 20 0 .01 - < 0.01 1.00E00 1.00E00 intramolecular oxidoreductase activity, interconverting aldoses and ketoses (GO:0016861) 6 0 .00 - < 0.01 1.00E00 1.00E00 histone H2B acetyltransferase activity (GO:0044013) 21 0 .01 - < 0.01 1.00E00 1.00E00 intramolecular oxidoreductase activity (GO:0016860) 52 0 .02 - < 0.01 1.00E00 1.00E00 histone H2AK9 acetyltransferase activity (GO:0044012) 20 0 .01 - < 0.01 1.00E00 1.00E00 protein kinase A regulatory subunit binding (GO:0034237) 26 0 .01 - < 0.01 1.00E00 1.00E00 protein kinase A catalytic subunit binding (GO:0034236) 14 0 .00 - < 0.01 1.00E00 1.00E00 GPI anchor binding (GO:0034235) 8 0 .00 - < 0.01 1.00E00 1.00E00 bile acid binding (GO:0032052) 10 0 .00 - < 0.01 1.00E00 1.00E00 clathrin light chain binding (GO:0032051) 7 0 .00 - < 0.01 1.00E00 1.00E00 clathrin heavy chain binding (GO:0032050) 11 0 .00 - < 0.01 1.00E00 1.00E00 cis-trans isomerase activity (GO:0016859) 43 0 .01 - < 0.01 1.00E00 1.00E00 hydroxyphenylpyruvate reductase activity (GO:0047995) 1 0 .00 - < 0.01 1.00E00 1.00E00 racemase and epimerase activity, acting on carbohydrates and derivatives (GO:0016857) 11 0 .00 - < 0.01 1.00E00 1.00E00 hydroxymethylglutaryl-CoA hydrolase activity (GO:0047994) 1 0 .00 - < 0.01 1.00E00 1.00E00 racemase and epimerase activity, acting on amino acids and derivatives (GO:0016855) 2 0 .00 - < 0.01 1.00E00 1.00E00 hydroxylysine kinase activity (GO:0047992) 1 0 .00 - < 0.01 1.00E00 1.00E00 racemase and epimerase activity (GO:0016854) 18 0 .01 - < 0.01 1.00E00 1.00E00 isomerase activity (GO:0016853) 180 0 .05 - < 0.01 1.00E00 1.00E00 histone H3K14 acetyltransferase activity (GO:0036408) 26 0 .01 - < 0.01 1.00E00 1.00E00 template-free RNA nucleotidyltransferase (GO:0098680) 1 0 .00 - < 0.01 1.00E00 1.00E00 translation factor activity (GO:0180051) 85 0 .02 - < 0.01 1.00E00 1.00E00 arachidonate 8(S)-lipoxygenase activity (GO:0036403) 2 0 .00 - < 0.01 1.00E00 1.00E00 proteasome-activating activity (GO:0036402) 6 0 .00 - < 0.01 1.00E00 1.00E00 ethanolamine transmembrane transporter activity (GO:0034228) 4 0 .00 - < 0.01 1.00E00 1.00E00 ciliary neurotrophic factor receptor activity (GO:0004897) 4 0 .00 - < 0.01 1.00E00 1.00E00 cytokine receptor activity (GO:0004896) 97 0 .03 - < 0.01 1.00E00 1.00E00 GABA-A receptor activity (GO:0004890) 19 0 .01 - < 0.01 1.00E00 1.00E00 histone H3K14 deacetylase activity, NAD-dependent (GO:0032041) 5 0 .00 - < 0.01 1.00E00 1.00E00 hydroxyacid-oxoacid transhydrogenase activity (GO:0047988) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphorus-oxygen lyase activity (GO:0016849) 24 0 .01 - < 0.01 1.00E00 1.00E00 carbon-sulfur lyase activity (GO:0016846) 15 0 .00 - < 0.01 1.00E00 1.00E00 homocysteine desulfhydrase activity (GO:0047982) 1 0 .00 - < 0.01 1.00E00 1.00E00 amidine-lyase activity (GO:0016842) 7 0 .00 - < 0.01 1.00E00 1.00E00 ammonia-lyase activity (GO:0016841) 5 0 .00 - < 0.01 1.00E00 1.00E00 carbon-nitrogen lyase activity (GO:0016840) 12 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane signaling receptor activity (GO:0004888) 1330 0 .39 - < 0.01 1.00E00 1.00E00 protein N-acetyltransferase activity (GO:0034212) 51 0 .01 - < 0.01 1.00E00 1.00E00 myosin II heavy chain binding (GO:0032038) 3 0 .00 - < 0.01 1.00E00 1.00E00 GTP-dependent protein kinase activity (GO:0034211) 1 0 .00 - < 0.01 1.00E00 1.00E00 myosin heavy chain binding (GO:0032036) 14 0 .00 - < 0.01 1.00E00 1.00E00 nuclear glucocorticoid receptor activity (GO:0004883) 1 0 .00 - < 0.01 1.00E00 1.00E00 myosin II head/neck binding (GO:0032034) 1 0 .00 - < 0.01 1.00E00 1.00E00 hepoxilin-epoxide hydrolase activity (GO:0047977) 1 0 .00 - < 0.01 1.00E00 1.00E00 carbon-oxygen lyase activity, acting on phosphates (GO:0016838) 3 0 .00 - < 0.01 1.00E00 1.00E00 guanosine phosphorylase activity (GO:0047975) 2 0 .00 - < 0.01 1.00E00 1.00E00 hydro-lyase activity (GO:0016836) 60 0 .02 - < 0.01 1.00E00 1.00E00 carbon-oxygen lyase activity (GO:0016835) 78 0 .02 - < 0.01 1.00E00 1.00E00 guanidinopropionase activity (GO:0047972) 1 0 .00 - < 0.01 1.00E00 1.00E00 guanidinobutyrase activity (GO:0047971) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxo-acid-lyase activity (GO:0016833) 7 0 .00 - < 0.01 1.00E00 1.00E00 aldehyde-lyase activity (GO:0016832) 9 0 .00 - < 0.01 1.00E00 1.00E00 carboxy-lyase activity (GO:0016831) 35 0 .01 - < 0.01 1.00E00 1.00E00 histone H4K8 deacetylase activity, hydrolytic mechanism (GO:0180033) 10 0 .00 - < 0.01 1.00E00 1.00E00 carbon-carbon lyase activity (GO:0016830) 52 0 .02 - < 0.01 1.00E00 1.00E00 histone H4K5 deacetylase activity, hydrolytic mechanism (GO:0180032) 10 0 .00 - < 0.01 1.00E00 1.00E00 inositol phosphate kinase activity (GO:0180030) 11 0 .00 - < 0.01 1.00E00 1.00E00 nuclear receptor activity (GO:0004879) 59 0 .02 - < 0.01 1.00E00 1.00E00 complement component C5a receptor activity (GO:0004878) 3 0 .00 - < 0.01 1.00E00 1.00E00 complement component C3b receptor activity (GO:0004877) 1 0 .00 - < 0.01 1.00E00 1.00E00 myosin tail binding (GO:0032029) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycolipid floppase activity (GO:0034202) 1 0 .00 - < 0.01 1.00E00 1.00E00 complement component C3a receptor activity (GO:0004876) 1 0 .00 - < 0.01 1.00E00 1.00E00 myosin head/neck binding (GO:0032028) 2 0 .00 - < 0.01 1.00E00 1.00E00 complement receptor activity (GO:0004875) 12 0 .00 - < 0.01 1.00E00 1.00E00 myosin light chain binding (GO:0032027) 8 0 .00 - < 0.01 1.00E00 1.00E00 asialoglycoprotein receptor activity (GO:0004873) 2 0 .00 - < 0.01 1.00E00 1.00E00 glyoxylate oxidase activity (GO:0047969) 1 0 .00 - < 0.01 1.00E00 1.00E00 lyase activity (GO:0016829) 201 0 .06 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on acid sulfur-nitrogen bonds (GO:0016826) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycine N-choloyltransferase activity (GO:0047963) 1 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on acid phosphorus-nitrogen bonds (GO:0016825) 2 0 .00 - < 0.01 1.00E00 1.00E00 glycine N-benzoyltransferase activity (GO:0047962) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycine N-acyltransferase activity (GO:0047961) 5 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances (GO:0016823) 3 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on acid carbon-carbon bonds (GO:0016822) 3 0 .00 - < 0.01 1.00E00 1.00E00 U6 snRNA 2'-O-ribose methyltransferase activity (GO:0180021) 1 0 .00 - < 0.01 1.00E00 1.00E00 membrane bending activity (GO:0180020) 1 0 .00 - < 0.01 1.00E00 1.00E00 cysteine-type endopeptidase inhibitor activity (GO:0004869) 37 0 .01 - < 0.01 1.00E00 1.00E00 serine-type endopeptidase inhibitor activity (GO:0004867) 102 0 .03 - < 0.01 1.00E00 1.00E00 endopeptidase inhibitor activity (GO:0004866) 169 0 .05 - < 0.01 1.00E00 1.00E00 protein serine/threonine phosphatase inhibitor activity (GO:0004865) 15 0 .00 - < 0.01 1.00E00 1.00E00 protein phosphatase inhibitor activity (GO:0004864) 54 0 .02 - < 0.01 1.00E00 1.00E00 cAMP-dependent protein kinase inhibitor activity (GO:0004862) 10 0 .00 - < 0.01 1.00E00 1.00E00 cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861) 13 0 .00 - < 0.01 1.00E00 1.00E00 protein kinase inhibitor activity (GO:0004860) 87 0 .03 - < 0.01 1.00E00 1.00E00 glycine:2-oxoglutarate aminotransferase activity (GO:0047958) 1 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides (GO:0016819) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycerol dehydrogenase (NADP+) activity (GO:0047956) 2 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 808 0 .24 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on acid anhydrides (GO:0016817) 808 0 .24 - < 0.01 1.00E00 1.00E00 glycerol-2-phosphatase activity (GO:0047954) 2 0 .00 - < 0.01 1.00E00 1.00E00 K11-linked deubiquitinase activity (GO:0180017) 1 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines (GO:0016814) 34 0 .01 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines (GO:0016813) 10 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides (GO:0016812) 15 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (GO:0016811) 67 0 .02 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (GO:0016810) 129 0 .04 - < 0.01 1.00E00 1.00E00 cadherin binding involved in cell-cell adhesion (GO:0098641) 18 0 .01 - < 0.01 1.00E00 1.00E00 integrin binding involved in cell-matrix adhesion (GO:0098640) 5 0 .00 - < 0.01 1.00E00 1.00E00 prosthetic group binding (GO:0051192) 1 0 .00 - < 0.01 1.00E00 1.00E00 phospholipase inhibitor activity (GO:0004859) 12 0 .00 - < 0.01 1.00E00 1.00E00 enzyme inhibitor activity (GO:0004857) 432 0 .13 - < 0.01 1.00E00 1.00E00 D-xylulokinase activity (GO:0004856) 1 0 .00 - < 0.01 1.00E00 1.00E00 xanthine oxidase activity (GO:0004855) 1 0 .00 - < 0.01 1.00E00 1.00E00 xanthine dehydrogenase activity (GO:0004854) 1 0 .00 - < 0.01 1.00E00 1.00E00 uroporphyrinogen decarboxylase activity (GO:0004853) 1 0 .00 - < 0.01 1.00E00 1.00E00 uroporphyrinogen-III synthase activity (GO:0004852) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-28 receptor binding (GO:0032003) 1 0 .00 - < 0.01 1.00E00 1.00E00 uridine phosphorylase activity (GO:0004850) 2 0 .00 - < 0.01 1.00E00 1.00E00 glutamine N-acyltransferase activity (GO:0047946) 2 0 .00 - < 0.01 1.00E00 1.00E00 collagen binding involved in cell-matrix adhesion (GO:0098639) 5 0 .00 - < 0.01 1.00E00 1.00E00 cysteine-type carboxypeptidase activity (GO:0016807) 3 0 .00 - < 0.01 1.00E00 1.00E00 broad specificity neutral L-amino acid:basic L-amino acid antiporter activity (GO:0180009) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity (GO:0180008) 80 0 .02 - < 0.01 1.00E00 1.00E00 dipeptidase activity (GO:0016805) 17 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity (GO:0180007) 80 0 .02 - < 0.01 1.00E00 1.00E00 glucuronolactone reductase activity (GO:0047941) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity (GO:0180006) 80 0 .02 - < 0.01 1.00E00 1.00E00 ether hydrolase activity (GO:0016803) 12 0 .00 - < 0.01 1.00E00 1.00E00 cell-matrix adhesion mediator activity (GO:0098634) 9 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity (GO:0180005) 80 0 .02 - < 0.01 1.00E00 1.00E00 collagen fibril binding (GO:0098633) 3 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity (GO:0180004) 80 0 .02 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on ether bonds (GO:0016801) 12 0 .00 - < 0.01 1.00E00 1.00E00 cell-cell adhesion mediator activity (GO:0098632) 58 0 .02 - < 0.01 1.00E00 1.00E00 S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity (GO:0180003) 1 0 .00 - < 0.01 1.00E00 1.00E00 cell adhesion mediator activity (GO:0098631) 78 0 .02 - < 0.01 1.00E00 1.00E00 leptin receptor binding (GO:1990460) 4 0 .00 - < 0.01 1.00E00 1.00E00 histone methyltransferase inhibitor activity (GO:0180000) 1 0 .00 - < 0.01 1.00E00 1.00E00 uridine kinase activity (GO:0004849) 4 0 .00 - < 0.01 1.00E00 1.00E00 mechanoreceptor activity (GO:0140897) 1 0 .00 - < 0.01 1.00E00 1.00E00 uracil DNA N-glycosylase activity (GO:0004844) 4 0 .00 - < 0.01 1.00E00 1.00E00 cysteine-type deubiquitinase activity (GO:0004843) 108 0 .03 - < 0.01 1.00E00 1.00E00 neutral amino acid, sodium:proton antiporter activity (GO:0140893) 1 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-protein transferase activity (GO:0004842) 449 0 .13 - < 0.01 1.00E00 1.00E00 sodium,bicarbonate:chloride antiporter activity (GO:0140892) 3 0 .00 - < 0.01 1.00E00 1.00E00 L-glucuronate reductase activity (GO:0047939) 2 0 .00 - < 0.01 1.00E00 1.00E00 glucose 1-dehydrogenase [NAD(P)+] activity (GO:0047936) 1 0 .00 - < 0.01 1.00E00 1.00E00 transferrin receptor binding (GO:1990459) 12 0 .00 - < 0.01 1.00E00 1.00E00 glucose 1-dehydrogenase (NADP+) activity (GO:0047935) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucose 1-dehydrogenase (NAD+) activity (GO:0047934) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucose-1,6-bisphosphate synthase activity (GO:0047933) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucosamine kinase activity (GO:0047931) 1 0 .00 - < 0.01 1.00E00 1.00E00 O-phosphoseryl-tRNA(Sec) selenium transferase activity (GO:0098621) 1 0 .00 - < 0.01 1.00E00 1.00E00 linear polyubiquitin binding (GO:1990450) 4 0 .00 - < 0.01 1.00E00 1.00E00 heme binding (GO:0020037) 142 1 .04 + 24.15 4.07E-02 1.00E00 histone H2AXS139 kinase activity (GO:0035979) 244 0 .07 - < 0.01 1.00E00 1.00E00 ubiquitin activating enzyme activity (GO:0004839) 3 0 .00 - < 0.01 1.00E00 1.00E00 L-tyrosine-2-oxoglutarate transaminase activity (GO:0004838) 1 0 .00 - < 0.01 1.00E00 1.00E00 tubulin-tyrosine ligase activity (GO:0004835) 1 0 .00 - < 0.01 1.00E00 1.00E00 thyroxine 5-deiodinase activity (GO:0033798) 2 0 .00 - < 0.01 1.00E00 1.00E00 tryptophan 2,3-dioxygenase activity (GO:0004833) 3 0 .00 - < 0.01 1.00E00 1.00E00 valine-tRNA ligase activity (GO:0004832) 2 0 .00 - < 0.01 1.00E00 1.00E00 tyrosine-tRNA ligase activity (GO:0004831) 2 0 .00 - < 0.01 1.00E00 1.00E00 tryptophan-tRNA ligase activity (GO:0004830) 2 0 .00 - < 0.01 1.00E00 1.00E00 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity (GO:0033791) 1 0 .00 - < 0.01 1.00E00 1.00E00 selenocysteine-tRNA ligase activity (GO:0098619) 1 0 .00 - < 0.01 1.00E00 1.00E00 exon-exon junction complex binding (GO:1990448) 1 0 .00 - < 0.01 1.00E00 1.00E00 U2 snRNP binding (GO:1990447) 2 0 .00 - < 0.01 1.00E00 1.00E00 U1 snRNP binding (GO:1990446) 7 0 .00 - < 0.01 1.00E00 1.00E00 F-box domain binding (GO:1990444) 3 0 .00 - < 0.01 1.00E00 1.00E00 sequence-specific DNA binding (GO:0043565) 1631 0 .48 - < 0.01 1.00E00 1.00E00 threonine-tRNA ligase activity (GO:0004829) 3 0 .00 - < 0.01 1.00E00 1.00E00 serine-tRNA ligase activity (GO:0004828) 2 0 .00 - < 0.01 1.00E00 1.00E00 insulin receptor substrate binding (GO:0043560) 13 0 .00 - < 0.01 1.00E00 1.00E00 proline-tRNA ligase activity (GO:0004827) 2 0 .00 - < 0.01 1.00E00 1.00E00 phenylalanine-tRNA ligase activity (GO:0004826) 4 0 .00 - < 0.01 1.00E00 1.00E00 methionine-tRNA ligase activity (GO:0004825) 2 0 .00 - < 0.01 1.00E00 1.00E00 lysine-tRNA ligase activity (GO:0004824) 1 0 .00 - < 0.01 1.00E00 1.00E00 leucine-tRNA ligase activity (GO:0004823) 2 0 .00 - < 0.01 1.00E00 1.00E00 cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity (GO:0033787) 1 0 .00 - < 0.01 1.00E00 1.00E00 isoleucine-tRNA ligase activity (GO:0004822) 2 0 .00 - < 0.01 1.00E00 1.00E00 histidine-tRNA ligase activity (GO:0004821) 2 0 .00 - < 0.01 1.00E00 1.00E00 glycine-tRNA ligase activity (GO:0004820) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase inhibitor activity (GO:0140870) 1 0 .00 - < 0.01 1.00E00 1.00E00 25-hydroxycholesterol 7-alpha-hydroxylase activity (GO:0033783) 1 0 .00 - < 0.01 1.00E00 1.00E00 GDP-mannose 3,5-epimerase activity (GO:0047918) 1 0 .00 - < 0.01 1.00E00 1.00E00 24S-hydroxycholesterol 7-alpha-hydroxylase activity (GO:0033782) 3 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol 24-hydroxylase activity (GO:0033781) 1 0 .00 - < 0.01 1.00E00 1.00E00 MAP kinase serine/threonine phosphatase activity (GO:1990439) 80 0 .02 - < 0.01 1.00E00 1.00E00 ganglioside galactosyltransferase activity (GO:0047915) 1 0 .00 - < 0.01 1.00E00 1.00E00 selenocystathionine gamma-lyase activity (GO:0098606) 1 0 .00 - < 0.01 1.00E00 1.00E00 extracellular matrix protein binding (GO:1990430) 5 0 .00 - < 0.01 1.00E00 1.00E00 insulin binding (GO:0043559) 5 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylethanolamine transfer activity (GO:1904121) 3 0 .00 - < 0.01 1.00E00 1.00E00 glutamine-tRNA ligase activity (GO:0004819) 2 0 .00 - < 0.01 1.00E00 1.00E00 glutamate-tRNA ligase activity (GO:0004818) 2 0 .00 - < 0.01 1.00E00 1.00E00 cysteine-tRNA ligase activity (GO:0004817) 2 0 .00 - < 0.01 1.00E00 1.00E00 asparagine-tRNA ligase activity (GO:0004816) 2 0 .00 - < 0.01 1.00E00 1.00E00 aspartate-tRNA ligase activity (GO:0004815) 2 0 .00 - < 0.01 1.00E00 1.00E00 arginine-tRNA ligase activity (GO:0004814) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AK129 ubiquitin ligase activity (GO:0140864) 2 0 .00 - < 0.01 1.00E00 1.00E00 alanine-tRNA ligase activity (GO:0004813) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AK127 ubiquitin ligase activity (GO:0140863) 2 0 .00 - < 0.01 1.00E00 1.00E00 aminoacyl-tRNA ligase activity (GO:0004812) 41 0 .01 - < 0.01 1.00E00 1.00E00 histone H2AK119 ubiquitin ligase activity (GO:0140862) 4 0 .00 - < 0.01 1.00E00 1.00E00 CCA tRNA nucleotidyltransferase activity (GO:0004810) 1 0 .00 - < 0.01 1.00E00 1.00E00 polyubiquitin modification-dependent protein binding (GO:0031593) 59 0 .02 - < 0.01 1.00E00 1.00E00 glyoxalase (glycolic acid-forming) activity (GO:1990422) 1 0 .00 - < 0.01 1.00E00 1.00E00 17-hydroxyprogesterone 21-hydroxylase activity (GO:0103069) 1 0 .00 - < 0.01 1.00E00 1.00E00 leukotriene C4 gamma-glutamyl transferase activity (GO:0103068) 5 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol 3-kinase binding (GO:0043548) 26 0 .01 - < 0.01 1.00E00 1.00E00 molybdopterin cofactor binding (GO:0043546) 6 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AK15 ubiquitin ligase activity (GO:0140858) 1 0 .00 - < 0.01 1.00E00 1.00E00 triose-phosphate isomerase activity (GO:0004807) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3T45 kinase activity (GO:0140857) 245 0 .07 - < 0.01 1.00E00 1.00E00 triacylglycerol lipase activity (GO:0004806) 24 0 .01 - < 0.01 1.00E00 1.00E00 histone H3S57 kinase activity (GO:0140855) 244 0 .07 - < 0.01 1.00E00 1.00E00 transposase activity (GO:0004803) 2 0 .00 - < 0.01 1.00E00 1.00E00 cholesterol-protein transferase activity (GO:0140853) 3 0 .00 - < 0.01 1.00E00 1.00E00 transketolase activity (GO:0004802) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone ubiquitin ligase activity (GO:0140852) 13 0 .00 - < 0.01 1.00E00 1.00E00 transaldolase activity (GO:0004801) 1 0 .00 - < 0.01 1.00E00 1.00E00 steroid dehydrogenase activity, acting on the CH-CH group of donors (GO:0033765) 3 0 .00 - < 0.01 1.00E00 1.00E00 thyroxine 5'-deiodinase activity (GO:0004800) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone H2B C-terminal K residue ubiquitin ligase activity (GO:0140850) 1 0 .00 - < 0.01 1.00E00 1.00E00 metal cation:proton antiporter activity (GO:0051139) 26 0 .01 - < 0.01 1.00E00 1.00E00 protein serine/threonine kinase activator activity (GO:0043539) 76 0 .02 - < 0.01 1.00E00 1.00E00 inositol 1,3,4,5 tetrakisphosphate binding (GO:0043533) 5 0 .00 - < 0.01 1.00E00 1.00E00 angiostatin binding (GO:0043532) 4 0 .00 - < 0.01 1.00E00 1.00E00 ADP binding (GO:0043531) 38 0 .01 - < 0.01 1.00E00 1.00E00 adenosine 5'-monophosphoramidase activity (GO:0043530) 4 0 .00 - < 0.01 1.00E00 1.00E00 amino acid:monoatomic cation antiporter activity (GO:0140848) 5 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity (GO:0140843) 2 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity (GO:0140842) 2 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II C-terminal domain O-GlcNAc transferase activity (GO:0140841) 2 0 .00 - < 0.01 1.00E00 1.00E00 indoleamine 2,3-dioxygenase activity (GO:0033754) 2 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity (GO:0140840) 36 0 .01 - < 0.01 1.00E00 1.00E00 adrenomedullin binding (GO:1990409) 2 0 .00 - < 0.01 1.00E00 1.00E00 calcitonin gene-related peptide binding (GO:1990407) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein antigen binding (GO:1990405) 7 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-protein mono-ADP-ribosyltransferase activity (GO:1990404) 23 0 .01 - < 0.01 1.00E00 1.00E00 mitochondrial ribosomal large subunit rRNA binding (GO:1990400) 1 0 .00 - < 0.01 1.00E00 1.00E00 ketoreductase activity (GO:0045703) 1 0 .00 - < 0.01 1.00E00 1.00E00 hepoxilin A3 synthase activity (GO:0051120) 1 0 .00 - < 0.01 1.00E00 1.00E00 5S rDNA binding (GO:0080084) 3 0 .00 - < 0.01 1.00E00 1.00E00 leucine zipper domain binding (GO:0043522) 11 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity (GO:0140839) 36 0 .01 - < 0.01 1.00E00 1.00E00 mRNA 3'-UTR AU-rich region binding (GO:0035925) 30 0 .01 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity (GO:0140838) 36 0 .01 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat S7 kinase activity (GO:0140837) 6 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat S5 kinase activity (GO:0140836) 6 0 .00 - < 0.01 1.00E00 1.00E00 histone H4R3 demethylase activity (GO:0033749) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat T4 kinase activity (GO:0140835) 6 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat S2 kinase activity (GO:0140834) 6 0 .00 - < 0.01 1.00E00 1.00E00 RNA polymerase II CTD heptapeptide repeat Y1 kinase activity (GO:0140833) 6 0 .00 - < 0.01 1.00E00 1.00E00 histone H3R2 demethylase activity (GO:0033746) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-histidine, sodium:proton antiporter activity (GO:0140832) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-methionine-(R)-S-oxide reductase activity (GO:0033745) 3 0 .00 - < 0.01 1.00E00 1.00E00 L-asparagine, sodium:proton antiporter activity (GO:0140831) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-methionine:thioredoxin-disulfide S-oxidoreductase activity (GO:0033744) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-glutamine, sodium:proton antiporter activity (GO:0140830) 2 0 .00 - < 0.01 1.00E00 1.00E00 peptide-methionine (R)-S-oxide reductase activity (GO:0033743) 4 0 .00 - < 0.01 1.00E00 1.00E00 sugar transmembrane transporter activity (GO:0051119) 26 0 .01 - < 0.01 1.00E00 1.00E00 ATPase binding (GO:0051117) 86 0 .03 - < 0.01 1.00E00 1.00E00 cellobiose glucosidase activity (GO:0080079) 1 0 .00 - < 0.01 1.00E00 1.00E00 kinetochore binding (GO:0043515) 6 0 .00 - < 0.01 1.00E00 1.00E00 bicarbonate:monoatomic anion antiporter activity (GO:0140829) 12 0 .00 - < 0.01 1.00E00 1.00E00 metal cation:monoatomic cation antiporter activity (GO:0140828) 41 0 .01 - < 0.01 1.00E00 1.00E00 zinc chaperone activity (GO:0140827) 1 0 .00 - < 0.01 1.00E00 1.00E00 zinc:proton antiporter activity (GO:0140826) 4 0 .00 - < 0.01 1.00E00 1.00E00 lactoperoxidase activity (GO:0140825) 4 0 .00 - < 0.01 1.00E00 1.00E00 thioredoxin-dependent peroxiredoxin activity (GO:0140824) 6 0 .00 - < 0.01 1.00E00 1.00E00 histone H2BS36 kinase activity (GO:0140823) 244 0 .07 - < 0.01 1.00E00 1.00E00 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity (GO:0140822) 1 0 .00 - < 0.01 1.00E00 1.00E00 aspartate dehydrogenase activity (GO:0033735) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidosqualene cyclase activity (GO:0031559) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-acylphosphatidylethanolamine-specific phospholipase D activity (GO:0070290) 1 0 .00 - < 0.01 1.00E00 1.00E00 fructose-1-phosphatase activity (GO:0103026) 2 0 .00 - < 0.01 1.00E00 1.00E00 ITPase activity (GO:0103023) 1 0 .00 - < 0.01 1.00E00 1.00E00 mRNA 5'-triphosphate monophosphatase activity (GO:0140818) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-histone H3S10 serine ADP-ribosyltransferase activity (GO:0140817) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-histone H2BS6 serine ADP-ribosyltransferase activity (GO:0140816) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-protein-histidine ADP-ribosyltransferase activity (GO:0140815) 1 0 .00 - < 0.01 1.00E00 1.00E00 ferritin receptor activity (GO:0070287) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AR3 arginine deiminase activity (GO:0140811) 4 0 .00 - < 0.01 1.00E00 1.00E00 histone H1R54 arginine deiminase activity (GO:0140810) 4 0 .00 - < 0.01 1.00E00 1.00E00 aldehyde dehydrogenase (NADP+) activity (GO:0033721) 2 0 .00 - < 0.01 1.00E00 1.00E00 pyridoxal binding (GO:0070280) 1 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-proline 4-dioxygenase activity (GO:0031545) 8 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-proline 3-dioxygenase activity (GO:0031544) 4 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-proline dioxygenase activity (GO:0031543) 12 0 .00 - < 0.01 1.00E00 1.00E00 bubble DNA binding (GO:0000405) 8 0 .00 - < 0.01 1.00E00 1.00E00 heteroduplex DNA loop binding (GO:0000404) 1 0 .00 - < 0.01 1.00E00 1.00E00 Y-form DNA binding (GO:0000403) 4 0 .00 - < 0.01 1.00E00 1.00E00 four-way junction DNA binding (GO:0000400) 18 0 .01 - < 0.01 1.00E00 1.00E00 histone H4R3 arginine deiminase activity (GO:0140809) 4 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-protein-tyrosine ADP-ribosyltransferase activity (GO:0140808) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-protein-glutamate ADP-ribosyltransferase activity (GO:0140807) 12 0 .00 - < 0.01 1.00E00 1.00E00 vitamin B6 binding (GO:0070279) 56 0 .02 - < 0.01 1.00E00 1.00E00 NAD+-protein-aspartate ADP-ribosyltransferase activity (GO:0140806) 13 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-protein-serine ADP-ribosyltransferase activity (GO:0140805) 2 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-protein-lysine ADP-ribosyltransferase activity (GO:0140804) 5 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-protein-cysteine ADP-ribosyltransferase activity (GO:0140803) 6 0 .00 - < 0.01 1.00E00 1.00E00 NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity (GO:0140802) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AXY142 kinase activity (GO:0140801) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-4-phosphate binding (GO:0070273) 31 0 .01 - < 0.01 1.00E00 1.00E00 gamma-aminobutyric acid:proton antiporter activity (GO:0140800) 1 0 .00 - < 0.01 1.00E00 1.00E00 thyrotropin-releasing hormone receptor binding (GO:0031531) 3 0 .00 - < 0.01 1.00E00 1.00E00 gonadotropin-releasing hormone receptor binding (GO:0031530) 2 0 .00 - < 0.01 1.00E00 1.00E00 GDP-D-glucose phosphorylase activity (GO:0080048) 1 0 .00 - < 0.01 1.00E00 1.00E00 16-hydroxypalmitate dehydrogenase activity (GO:0103002) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor (GO:0052890) 12 0 .00 - < 0.01 1.00E00 1.00E00 hexose:proton symporter activity (GO:0009679) 2 0 .00 - < 0.01 1.00E00 1.00E00 nickel cation transmembrane transporter activity (GO:0015099) 1 0 .00 - < 0.01 1.00E00 1.00E00 3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity (GO:0033703) 2 0 .00 - < 0.01 1.00E00 1.00E00 molybdate ion transmembrane transporter activity (GO:0015098) 1 0 .00 - < 0.01 1.00E00 1.00E00 5'-tyrosyl-DNA phosphodiesterase activity (GO:0070260) 1 0 .00 - < 0.01 1.00E00 1.00E00 potassium:sodium symporter activity (GO:0009674) 3 0 .00 - < 0.01 1.00E00 1.00E00 low-affinity phosphate transmembrane transporter activity (GO:0009673) 1 0 .00 - < 0.01 1.00E00 1.00E00 magnesium ion transmembrane transporter activity (GO:0015095) 20 0 .01 - < 0.01 1.00E00 1.00E00 lead ion transmembrane transporter activity (GO:0015094) 1 0 .00 - < 0.01 1.00E00 1.00E00 ferrous iron transmembrane transporter activity (GO:0015093) 6 0 .00 - < 0.01 1.00E00 1.00E00 all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity (GO:0052885) 1 0 .00 - < 0.01 1.00E00 1.00E00 all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity (GO:0052884) 1 0 .00 - < 0.01 1.00E00 1.00E00 tyrosyl-DNA phosphodiesterase activity (GO:0070259) 2 0 .00 - < 0.01 1.00E00 1.00E00 sucrose:monoatomic cation symporter activity (GO:0009669) 4 0 .00 - < 0.01 1.00E00 1.00E00 ligand-gated monoatomic anion channel activity (GO:0099095) 47 0 .01 - < 0.01 1.00E00 1.00E00 ligand-gated monoatomic cation channel activity (GO:0099094) 137 0 .04 - < 0.01 1.00E00 1.00E00 pristanate-CoA ligase activity (GO:0070251) 2 0 .00 - < 0.01 1.00E00 1.00E00 cobalt ion transmembrane transporter activity (GO:0015087) 2 0 .00 - < 0.01 1.00E00 1.00E00 cadmium ion transmembrane transporter activity (GO:0015086) 3 0 .00 - < 0.01 1.00E00 1.00E00 calcium ion transmembrane transporter activity (GO:0015085) 145 0 .04 - < 0.01 1.00E00 1.00E00 sodium ion transmembrane transporter activity (GO:0015081) 165 0 .05 - < 0.01 1.00E00 1.00E00 silver ion transmembrane transporter activity (GO:0015080) 1 0 .00 - < 0.01 1.00E00 1.00E00 FMN reductase (NADH) activity (GO:0052874) 1 0 .00 - < 0.01 1.00E00 1.00E00 FMN reductase (NADPH) activity (GO:0052873) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol-3,5-bisphosphate binding (GO:0080025) 28 0 .01 - < 0.01 1.00E00 1.00E00 WW domain binding (GO:0050699) 24 0 .01 - < 0.01 1.00E00 1.00E00 proteoglycan sulfotransferase activity (GO:0050698) 28 0 .01 - < 0.01 1.00E00 1.00E00 alpha-tocopherol omega-hydroxylase activity (GO:0052871) 1 0 .00 - < 0.01 1.00E00 1.00E00 galactose 3-O-sulfotransferase activity (GO:0050694) 4 0 .00 - < 0.01 1.00E00 1.00E00 LBD domain binding (GO:0050693) 7 0 .00 - < 0.01 1.00E00 1.00E00 DNA binding domain binding (GO:0050692) 4 0 .00 - < 0.01 1.00E00 1.00E00 potassium ion transmembrane transporter activity (GO:0015079) 161 0 .05 - < 0.01 1.00E00 1.00E00 proton transmembrane transporter activity (GO:0015078) 185 0 .05 - < 0.01 1.00E00 1.00E00 monoatomic ion transmembrane transporter activity (GO:0015075) 765 0 .22 - < 0.01 1.00E00 1.00E00 oleate transmembrane transporter activity (GO:1901480) 2 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate omega-hydroxylase activity (GO:0052869) 5 0 .00 - < 0.01 1.00E00 1.00E00 alcohol-forming very long-chain fatty acyl-CoA reductase activity (GO:0080019) 2 0 .00 - < 0.01 1.00E00 1.00E00 proline:sodium symporter activity (GO:0005298) 5 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol phosphate phosphatase activity (GO:0052866) 34 0 .01 - < 0.01 1.00E00 1.00E00 proline:proton symporter activity (GO:0005297) 2 0 .00 - < 0.01 1.00E00 1.00E00 neutral L-amino acid:sodium symporter activity (GO:0005295) 8 0 .00 - < 0.01 1.00E00 1.00E00 high-affinity lysine transmembrane transporter activity (GO:0005292) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-histidine transmembrane transporter activity (GO:0005290) 5 0 .00 - < 0.01 1.00E00 1.00E00 AF-1 domain binding (GO:0050683) 1 0 .00 - < 0.01 1.00E00 1.00E00 AF-2 domain binding (GO:0050682) 4 0 .00 - < 0.01 1.00E00 1.00E00 nuclear androgen receptor binding (GO:0050681) 26 0 .01 - < 0.01 1.00E00 1.00E00 histone-dependent DNA binding (GO:0099077) 1 0 .00 - < 0.01 1.00E00 1.00E00 glycine amidinotransferase activity (GO:0015068) 1 0 .00 - < 0.01 1.00E00 1.00E00 amidinotransferase activity (GO:0015067) 1 0 .00 - < 0.01 1.00E00 1.00E00 azole transmembrane transporter activity (GO:1901474) 14 0 .00 - < 0.01 1.00E00 1.00E00 high-affinity L-arginine transmembrane transporter activity (GO:0005289) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD(P)HX epimerase activity (GO:0052856) 2 0 .00 - < 0.01 1.00E00 1.00E00 high-affinity basic amino acid transmembrane transporter activity (GO:0005287) 1 0 .00 - < 0.01 1.00E00 1.00E00 S-nitrosoglutathione reductase (NADH) activity (GO:0080007) 2 0 .00 - < 0.01 1.00E00 1.00E00 amino acid:sodium symporter activity (GO:0005283) 23 0 .01 - < 0.01 1.00E00 1.00E00 ferric-chelate reductase (NADPH) activity (GO:0052851) 3 0 .00 - < 0.01 1.00E00 1.00E00 amino acid:proton symporter activity (GO:0005280) 6 0 .00 - < 0.01 1.00E00 1.00E00 sulfide:quinone oxidoreductase activity (GO:0070224) 1 0 .00 - < 0.01 1.00E00 1.00E00 thrombin-activated receptor activity (GO:0015057) 5 0 .00 - < 0.01 1.00E00 1.00E00 corticotrophin-releasing factor receptor activity (GO:0015056) 2 0 .00 - < 0.01 1.00E00 1.00E00 secretin receptor activity (GO:0015055) 1 0 .00 - < 0.01 1.00E00 1.00E00 gastrin receptor activity (GO:0015054) 1 0 .00 - < 0.01 1.00E00 1.00E00 beta3-adrenergic receptor activity (GO:0015052) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity (GO:0052848) 2 0 .00 - < 0.01 1.00E00 1.00E00 acetylcholine:proton antiporter activity (GO:0005278) 1 0 .00 - < 0.01 1.00E00 1.00E00 acetylcholine transmembrane transporter activity (GO:0005277) 4 0 .00 - < 0.01 1.00E00 1.00E00 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity (GO:0052845) 2 0 .00 - < 0.01 1.00E00 1.00E00 amine transmembrane transporter activity (GO:0005275) 8 0 .00 - < 0.01 1.00E00 1.00E00 inositol diphosphate pentakisphosphate diphosphatase activity (GO:0052842) 2 0 .00 - < 0.01 1.00E00 1.00E00 inositol bisdiphosphate tetrakisphosphate diphosphatase activity (GO:0052841) 2 0 .00 - < 0.01 1.00E00 1.00E00 sodium channel activity (GO:0005272) 52 0 .02 - < 0.01 1.00E00 1.00E00 inositol diphosphate tetrakisphosphate diphosphatase activity (GO:0052840) 2 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor (GO:0050664) 17 0 .00 - < 0.01 1.00E00 1.00E00 NADP binding (GO:0050661) 55 1 .02 + 62.36 1.59E-02 1.00E00 flavin adenine dinucleotide binding (GO:0050660) 87 0 .03 - < 0.01 1.00E00 1.00E00 diphosphoinositol tetrakisphosphate kinase activity (GO:0052839) 3 0 .00 - < 0.01 1.00E00 1.00E00 inositol 5-diphosphate pentakisphosphate 5-kinase activity (GO:0052836) 3 0 .00 - < 0.01 1.00E00 1.00E00 potassium channel activity (GO:0005267) 125 0 .04 - < 0.01 1.00E00 1.00E00 inositol-3,4,6-trisphosphate 1-kinase activity (GO:0052835) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol monophosphate phosphatase activity (GO:0052834) 3 0 .00 - < 0.01 1.00E00 1.00E00 inositol monophosphate 4-phosphatase activity (GO:0052833) 3 0 .00 - < 0.01 1.00E00 1.00E00 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity (GO:0050659) 2 0 .00 - < 0.01 1.00E00 1.00E00 inositol monophosphate 3-phosphatase activity (GO:0052832) 2 0 .00 - < 0.01 1.00E00 1.00E00 calcium channel activity (GO:0005262) 129 0 .04 - < 0.01 1.00E00 1.00E00 3'-phosphoadenosine 5'-phosphosulfate binding (GO:0050656) 10 0 .00 - < 0.01 1.00E00 1.00E00 monoatomic cation channel activity (GO:0005261) 340 0 .10 - < 0.01 1.00E00 1.00E00 intracellularly ATP-gated chloride channel activity (GO:0005260) 1 0 .00 - < 0.01 1.00E00 1.00E00 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity (GO:0102571) 1 0 .00 - < 0.01 1.00E00 1.00E00 NADPH-adrenodoxin reductase activity (GO:0015039) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutathione disulfide oxidoreductase activity (GO:0015038) 5 0 .00 - < 0.01 1.00E00 1.00E00 disulfide oxidoreductase activity (GO:0015036) 41 0 .01 - < 0.01 1.00E00 1.00E00 protein-disulfide reductase activity (GO:0015035) 35 0 .01 - < 0.01 1.00E00 1.00E00 inositol-1,3,4-trisphosphate 1-phosphatase activity (GO:0052829) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol-3,4-bisphosphate 4-phosphatase activity (GO:0052828) 2 0 .00 - < 0.01 1.00E00 1.00E00 peptidyl-dipeptidase inhibitor activity (GO:0060422) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol pentakisphosphate phosphatase activity (GO:0052827) 2 0 .00 - < 0.01 1.00E00 1.00E00 inositol hexakisphosphate 2-phosphatase activity (GO:0052826) 1 0 .00 - < 0.01 1.00E00 1.00E00 thiocyanate peroxidase activity (GO:0036393) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA-3-methylguanine glycosylase activity (GO:0052822) 1 0 .00 - < 0.01 1.00E00 1.00E00 testosterone 6-beta-hydroxylase activity (GO:0050649) 6 0 .00 - < 0.01 1.00E00 1.00E00 chloride channel activity (GO:0005254) 82 0 .02 - < 0.01 1.00E00 1.00E00 DNA-7-methyladenine glycosylase activity (GO:0052821) 1 0 .00 - < 0.01 1.00E00 1.00E00 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding (GO:0050648) 1 0 .00 - < 0.01 1.00E00 1.00E00 monoatomic anion channel activity (GO:0005253) 102 0 .03 - < 0.01 1.00E00 1.00E00 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding (GO:0050647) 1 0 .00 - < 0.01 1.00E00 1.00E00 open rectifier potassium channel activity (GO:0005252) 1 0 .00 - < 0.01 1.00E00 1.00E00 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding (GO:0050646) 1 0 .00 - < 0.01 1.00E00 1.00E00 delayed rectifier potassium channel activity (GO:0005251) 25 0 .01 - < 0.01 1.00E00 1.00E00 A-type (transient outward) potassium channel activity (GO:0005250) 4 0 .00 - < 0.01 1.00E00 1.00E00 ceramide floppase activity (GO:0099038) 2 0 .00 - < 0.01 1.00E00 1.00E00 coreceptor activity (GO:0015026) 61 0 .02 - < 0.01 1.00E00 1.00E00 glucuronate-2-sulfatase activity (GO:0015024) 1 0 .00 - < 0.01 1.00E00 1.00E00 glucuronosyltransferase activity (GO:0015020) 34 0 .01 - < 0.01 1.00E00 1.00E00 voltage-gated potassium channel activity (GO:0005249) 98 0 .03 - < 0.01 1.00E00 1.00E00 very long-chain fatty acyl-CoA hydrolase activity (GO:0052817) 2 0 .00 - < 0.01 1.00E00 1.00E00 long-chain fatty acyl-CoA hydrolase activity (GO:0052816) 14 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated sodium channel activity (GO:0005248) 21 0 .01 - < 0.01 1.00E00 1.00E00 medium-chain fatty acyl-CoA hydrolase activity (GO:0052815) 2 0 .00 - < 0.01 1.00E00 1.00E00 CDP phosphatase activity (GO:0036384) 4 0 .00 - < 0.01 1.00E00 1.00E00 voltage-gated chloride channel activity (GO:0005247) 11 0 .00 - < 0.01 1.00E00 1.00E00 medium-chain fatty aldehyde dehydrogenase (NAD+) activity (GO:0052814) 3 0 .00 - < 0.01 1.00E00 1.00E00 calcium channel regulator activity (GO:0005246) 53 0 .02 - < 0.01 1.00E00 1.00E00 voltage-gated calcium channel activity (GO:0005245) 43 0 .01 - < 0.01 1.00E00 1.00E00 voltage-gated monoatomic ion channel activity (GO:0005244) 172 0 .05 - < 0.01 1.00E00 1.00E00 gap junction channel activity (GO:0005243) 22 0 .01 - < 0.01 1.00E00 1.00E00 1-phosphatidylinositol-5-kinase activity (GO:0052810) 3 0 .00 - < 0.01 1.00E00 1.00E00 inward rectifier potassium channel activity (GO:0005242) 28 0 .01 - < 0.01 1.00E00 1.00E00 protein-(glutamine-N5) methyltransferase activity (GO:0102559) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA NAD-cap (NMN-forming) hydrolase activity (GO:0110153) 2 0 .00 - < 0.01 1.00E00 1.00E00 acetyl-CoA C-myristoyltransferase activity (GO:0050633) 3 0 .00 - < 0.01 1.00E00 1.00E00 RNA NAD+-cap (NAD+-forming) hydrolase activity (GO:0110152) 1 0 .00 - < 0.01 1.00E00 1.00E00 propionyl-CoA C2-trimethyltridecanoyltransferase activity (GO:0050632) 1 0 .00 - < 0.01 1.00E00 1.00E00 heparan-alpha-glucosaminide N-acetyltransferase activity (GO:0015019) 1 0 .00 - < 0.01 1.00E00 1.00E00 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity (GO:0015018) 3 0 .00 - < 0.01 1.00E00 1.00E00 heparan sulfate N-sulfotransferase activity (GO:0015016) 4 0 .00 - < 0.01 1.00E00 1.00E00 glutathione hydrolase activity (GO:0036374) 8 0 .00 - < 0.01 1.00E00 1.00E00 inhibitory extracellular ligand-gated monoatomic ion channel activity (GO:0005237) 4 0 .00 - < 0.01 1.00E00 1.00E00 L-fucose mutarotase activity (GO:0036373) 1 0 .00 - < 0.01 1.00E00 1.00E00 extracellularly glutamate-gated ion channel activity (GO:0005234) 2 0 .00 - < 0.01 1.00E00 1.00E00 excitatory extracellular ligand-gated monoatomic ion channel activity (GO:0005231) 36 0 .01 - < 0.01 1.00E00 1.00E00 extracellular ligand-gated monoatomic ion channel activity (GO:0005230) 73 0 .02 - < 0.01 1.00E00 1.00E00 apolipoprotein A-I receptor binding (GO:0034191) 4 0 .00 - < 0.01 1.00E00 1.00E00 apolipoprotein receptor binding (GO:0034190) 7 0 .00 - < 0.01 1.00E00 1.00E00 WD40-repeat domain binding (GO:0071987) 4 0 .00 - < 0.01 1.00E00 1.00E00 intracellularly calcium-gated chloride channel activity (GO:0005229) 19 0 .01 - < 0.01 1.00E00 1.00E00 intracellular sodium-activated potassium channel activity (GO:0005228) 2 0 .00 - < 0.01 1.00E00 1.00E00 calcium-activated cation channel activity (GO:0005227) 26 0 .01 - < 0.01 1.00E00 1.00E00 very-low-density lipoprotein particle binding (GO:0034189) 5 0 .00 - < 0.01 1.00E00 1.00E00 volume-sensitive anion channel activity (GO:0005225) 11 0 .00 - < 0.01 1.00E00 1.00E00 apolipoprotein A-I receptor activity (GO:0034188) 2 0 .00 - < 0.01 1.00E00 1.00E00 intracellularly cGMP-activated cation channel activity (GO:0005223) 7 0 .00 - < 0.01 1.00E00 1.00E00 apolipoprotein A-I binding (GO:0034186) 5 0 .00 - < 0.01 1.00E00 1.00E00 intracellularly cAMP-activated cation channel activity (GO:0005222) 9 0 .00 - < 0.01 1.00E00 1.00E00 apolipoprotein binding (GO:0034185) 18 0 .01 - < 0.01 1.00E00 1.00E00 intracellularly cyclic nucleotide-activated monoatomic cation channel activity (GO:0005221) 11 0 .00 - < 0.01 1.00E00 1.00E00 inositol 1,4,5-trisphosphate-gated calcium channel activity (GO:0005220) 3 0 .00 - < 0.01 1.00E00 1.00E00 Delta24-sterol reductase activity (GO:0050614) 1 0 .00 - < 0.01 1.00E00 1.00E00 Delta14-sterol reductase activity (GO:0050613) 2 0 .00 - < 0.01 1.00E00 1.00E00 methylarsonate reductase activity (GO:0050610) 2 0 .00 - < 0.01 1.00E00 1.00E00 ryanodine-sensitive calcium-release channel activity (GO:0005219) 3 0 .00 - < 0.01 1.00E00 1.00E00 intracellularly ligand-gated monoatomic ion channel activity (GO:0005217) 29 0 .01 - < 0.01 1.00E00 1.00E00 monoatomic ion channel activity (GO:0005216) 447 0 .13 - < 0.01 1.00E00 1.00E00 transporter activity (GO:0005215) 1254 0 .37 - < 0.01 1.00E00 1.00E00 structural constituent of eye lens (GO:0005212) 23 0 .01 - < 0.01 1.00E00 1.00E00 calcium-dependent protein binding (GO:0048306) 80 0 .02 - < 0.01 1.00E00 1.00E00 tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity (GO:0102524) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity (GO:0102522) 1 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-4-demethylwyosine synthase activity (GO:0102521) 2 0 .00 - < 0.01 1.00E00 1.00E00 hydrolase activity, hydrolyzing N-glycosyl compounds (GO:0016799) 39 0 .01 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on glycosyl bonds (GO:0016798) 130 0 .04 - < 0.01 1.00E00 1.00E00 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters (GO:0016796) 62 0 .02 - < 0.01 1.00E00 1.00E00 phosphoric triester hydrolase activity (GO:0016795) 2 0 .00 - < 0.01 1.00E00 1.00E00 diphosphoric monoester hydrolase activity (GO:0016794) 1 0 .00 - < 0.01 1.00E00 1.00E00 triphosphoric monoester hydrolase activity (GO:0016793) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatase activity (GO:0016791) 272 0 .08 - < 0.01 1.00E00 1.00E00 thiolester hydrolase activity (GO:0016790) 44 0 .01 - < 0.01 1.00E00 1.00E00 extracellular matrix structural constituent (GO:0005201) 168 0 .05 - < 0.01 1.00E00 1.00E00 structural constituent of cytoskeleton (GO:0005200) 114 0 .03 - < 0.01 1.00E00 1.00E00 hydrolase activity, acting on ester bonds (GO:0016788) 769 0 .22 - < 0.01 1.00E00 1.00E00 hydrolase activity (GO:0016787) 2440 0 .71 - < 0.01 1.00E00 1.00E00 selenotransferase activity (GO:0016785) 1 0 .00 - < 0.01 1.00E00 1.00E00 3-mercaptopyruvate sulfurtransferase activity (GO:0016784) 2 0 .00 - < 0.01 1.00E00 1.00E00 sulfurtransferase activity (GO:0016783) 10 0 .00 - < 0.01 1.00E00 1.00E00 transferase activity, transferring sulphur-containing groups (GO:0016782) 70 0 .02 - < 0.01 1.00E00 1.00E00 phosphotransferase activity, paired acceptors (GO:0016781) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphotransferase activity, for other substituted phosphate groups (GO:0016780) 22 0 .01 - < 0.01 1.00E00 1.00E00 placental growth factor receptor activity (GO:0036332) 49 0 .01 - < 0.01 1.00E00 1.00E00 FAD binding (GO:0071949) 41 0 .01 - < 0.01 1.00E00 1.00E00 nucleotidyltransferase activity (GO:0016779) 150 0 .04 - < 0.01 1.00E00 1.00E00 diphosphotransferase activity (GO:0016778) 4 0 .00 - < 0.01 1.00E00 1.00E00 phosphotransferase activity, phosphate group as acceptor (GO:0016776) 40 0 .01 - < 0.01 1.00E00 1.00E00 phosphotransferase activity, nitrogenous group as acceptor (GO:0016775) 6 0 .00 - < 0.01 1.00E00 1.00E00 phosphotransferase activity, carboxyl group as acceptor (GO:0016774) 3 0 .00 - < 0.01 1.00E00 1.00E00 phosphotransferase activity, alcohol group as acceptor (GO:0016773) 671 0 .20 - < 0.01 1.00E00 1.00E00 transferase activity, transferring phosphorus-containing groups (GO:0016772) 895 0 .26 - < 0.01 1.00E00 1.00E00 Arp2/3 complex binding (GO:0071933) 14 0 .00 - < 0.01 1.00E00 1.00E00 transferase activity, transferring nitrogenous groups (GO:0016769) 30 0 .01 - < 0.01 1.00E00 1.00E00 palmitoyl hydrolase activity (GO:0098599) 14 0 .00 - < 0.01 1.00E00 1.00E00 spermine synthase activity (GO:0016768) 1 0 .00 - < 0.01 1.00E00 1.00E00 transferase activity, transferring alkyl or aryl (other than methyl) groups (GO:0016765) 61 0 .02 - < 0.01 1.00E00 1.00E00 pentosyltransferase activity (GO:0016763) 49 0 .01 - < 0.01 1.00E00 1.00E00 tyrosyl-RNA phosphodiesterase activity (GO:0036317) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol 3-kinase catalytic subunit binding (GO:0036313) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol 3-kinase regulatory subunit binding (GO:0036312) 11 0 .00 - < 0.01 1.00E00 1.00E00 ATP-dependent DNA/DNA annealing activity (GO:0036310) 5 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K4 deacetylase activity, NAD-dependent (GO:0141222) 5 0 .00 - < 0.01 1.00E00 1.00E00 histone deacetylase activity, hydrolytic mechanism (GO:0141221) 12 0 .00 - < 0.01 1.00E00 1.00E00 hexosyltransferase activity (GO:0016758) 196 0 .06 - < 0.01 1.00E00 1.00E00 flavonol 3-sulfotransferase activity (GO:0047894) 3 0 .00 - < 0.01 1.00E00 1.00E00 glycosyltransferase activity (GO:0016757) 266 0 .08 - < 0.01 1.00E00 1.00E00 aminoacyltransferase activity (GO:0016755) 496 0 .14 - < 0.01 1.00E00 1.00E00 S-succinyltransferase activity (GO:0016751) 1 0 .00 - < 0.01 1.00E00 1.00E00 NAD-dependent protein lysine deacylase activity (GO:0141218) 7 0 .00 - < 0.01 1.00E00 1.00E00 N-acetyltaurine hydrolase activity (GO:0141215) 1 0 .00 - < 0.01 1.00E00 1.00E00 thymidylate synthase activity (GO:0004799) 1 0 .00 - < 0.01 1.00E00 1.00E00 dTMP kinase activity (GO:0004798) 2 0 .00 - < 0.01 1.00E00 1.00E00 thymidine kinase activity (GO:0004797) 2 0 .00 - < 0.01 1.00E00 1.00E00 thromboxane-A synthase activity (GO:0004796) 2 0 .00 - < 0.01 1.00E00 1.00E00 threonine deaminase activity (GO:0004794) 2 0 .00 - < 0.01 1.00E00 1.00E00 threonine aldolase activity (GO:0004793) 1 0 .00 - < 0.01 1.00E00 1.00E00 thiosulfate-cyanide sulfurtransferase activity (GO:0004792) 3 0 .00 - < 0.01 1.00E00 1.00E00 dipeptide transmembrane transporter activity (GO:0071916) 5 0 .00 - < 0.01 1.00E00 1.00E00 thioredoxin-disulfide reductase (NADPH) activity (GO:0004791) 7 0 .00 - < 0.01 1.00E00 1.00E00 thioether S-methyltransferase activity (GO:0004790) 1 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid peroxidase activity (GO:0047888) 1 0 .00 - < 0.01 1.00E00 1.00E00 citrate secondary active transmembrane transporter activity (GO:0071913) 1 0 .00 - < 0.01 1.00E00 1.00E00 N-succinyltransferase activity (GO:0016749) 2 0 .00 - < 0.01 1.00E00 1.00E00 succinyltransferase activity (GO:0016748) 3 0 .00 - < 0.01 1.00E00 1.00E00 acyltransferase activity, transferring groups other than amino-acyl groups (GO:0016747) 227 0 .07 - < 0.01 1.00E00 1.00E00 acyltransferase activity (GO:0016746) 729 0 .21 - < 0.01 1.00E00 1.00E00 estradiol 17-alpha-dehydrogenase [NAD(P)+] activity (GO:0047881) 1 0 .00 - < 0.01 1.00E00 1.00E00 transketolase or transaldolase activity (GO:0016744) 5 0 .00 - < 0.01 1.00E00 1.00E00 carboxyl- or carbamoyltransferase activity (GO:0016743) 2 0 .00 - < 0.01 1.00E00 1.00E00 hydroxymethyl-, formyl- and related transferase activity (GO:0016742) 8 0 .00 - < 0.01 1.00E00 1.00E00 transferase activity, transferring one-carbon groups (GO:0016741) 216 0 .06 - < 0.01 1.00E00 1.00E00 transferase activity (GO:0016740) 2249 0 .66 - < 0.01 1.00E00 1.00E00 NAD-dependent protein lysine delactylase activity (GO:0141208) 2 0 .00 - < 0.01 1.00E00 1.00E00 peptide lactyltransferase (ATP-dependent) activity (GO:0141207) 2 0 .00 - < 0.01 1.00E00 1.00E00 non-ribosomal peptide synthetase activity (GO:1904091) 1 0 .00 - < 0.01 1.00E00 1.00E00 thiamine diphosphokinase activity (GO:0004788) 1 0 .00 - < 0.01 1.00E00 1.00E00 UTP thiamine diphosphokinase activity (GO:0141200) 1 0 .00 - < 0.01 1.00E00 1.00E00 superoxide dismutase activity (GO:0004784) 5 0 .00 - < 0.01 1.00E00 1.00E00 sulfinoalanine decarboxylase activity (GO:0004782) 2 0 .00 - < 0.01 1.00E00 1.00E00 sulfate adenylyltransferase (ATP) activity (GO:0004781) 2 0 .00 - < 0.01 1.00E00 1.00E00 dolichyldiphosphatase activity (GO:0047874) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor (GO:0016731) 2 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on iron-sulfur proteins as donors (GO:0016730) 2 0 .00 - < 0.01 1.00E00 1.00E00 sulfate adenylyltransferase activity (GO:0004779) 2 0 .00 - < 0.01 1.00E00 1.00E00 succinyl-CoA hydrolase activity (GO:0004778) 2 0 .00 - < 0.01 1.00E00 1.00E00 succinate-semialdehyde dehydrogenase (NAD+) activity (GO:0004777) 1 0 .00 - < 0.01 1.00E00 1.00E00 succinate-CoA ligase (GDP-forming) activity (GO:0004776) 2 0 .00 - < 0.01 1.00E00 1.00E00 succinate-CoA ligase (ADP-forming) activity (GO:0004775) 2 0 .00 - < 0.01 1.00E00 1.00E00 succinate-CoA ligase activity (GO:0004774) 3 0 .00 - < 0.01 1.00E00 1.00E00 steryl-sulfatase activity (GO:0004773) 1 0 .00 - < 0.01 1.00E00 1.00E00 sterol O-acyltransferase activity (GO:0004772) 3 0 .00 - < 0.01 1.00E00 1.00E00 sterol ester esterase activity (GO:0004771) 8 0 .00 - < 0.01 1.00E00 1.00E00 dimethylglycine dehydrogenase activity (GO:0047865) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor (GO:0016728) 5 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor (GO:0016727) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor (GO:0016726) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on CH or CH2 groups (GO:0016725) 11 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on metal ions, oxygen as acceptor (GO:0016724) 6 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor (GO:0016723) 5 0 .00 - < 0.01 1.00E00 1.00E00 diiodophenylpyruvate reductase activity (GO:0047860) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on metal ions (GO:0016722) 16 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on superoxide radicals as acceptor (GO:0016721) 5 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-specific protease binding (GO:1990381) 18 0 .01 - < 0.01 1.00E00 1.00E00 K48-linked deubiquitinase activity (GO:1990380) 19 0 .01 - < 0.01 1.00E00 1.00E00 steroid Delta-isomerase activity (GO:0004769) 4 0 .00 - < 0.01 1.00E00 1.00E00 stearoyl-CoA 9-desaturase activity (GO:0004768) 3 0 .00 - < 0.01 1.00E00 1.00E00 sphingomyelin phosphodiesterase activity (GO:0004767) 6 0 .00 - < 0.01 1.00E00 1.00E00 spermidine synthase activity (GO:0004766) 1 0 .00 - < 0.01 1.00E00 1.00E00 L-serine-pyruvate transaminase activity (GO:0004760) 1 0 .00 - < 0.01 1.00E00 1.00E00 FMN binding (GO:0010181) 15 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (GO:0016717) 11 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen (GO:0016716) 9 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen (GO:0016715) 5 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen (GO:0016714) 7 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (GO:0016713) 10 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712) 47 1 .01 + 72.98 1.36E-02 1.00E00 flavonoid 3'-monooxygenase activity (GO:0016711) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein-membrane adaptor activity (GO:0043495) 47 0 .01 - < 0.01 1.00E00 1.00E00 serine C-palmitoyltransferase activity (GO:0004758) 5 0 .00 - < 0.01 1.00E00 1.00E00 sepiapterin reductase (NADP+) activity (GO:0004757) 1 0 .00 - < 0.01 1.00E00 1.00E00 selenide, water dikinase activity (GO:0004756) 2 0 .00 - < 0.01 1.00E00 1.00E00 saccharopine dehydrogenase (NAD+, L-lysine-forming) activity (GO:0004754) 1 0 .00 - < 0.01 1.00E00 1.00E00 saccharopine dehydrogenase activity (GO:0004753) 1 0 .00 - < 0.01 1.00E00 1.00E00 ribose-5-phosphate isomerase activity (GO:0004751) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-ribulose-phosphate 3-epimerase activity (GO:0004750) 2 0 .00 - < 0.01 1.00E00 1.00E00 deoxyuridine phosphorylase activity (GO:0047847) 2 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709) 35 0 .01 - < 0.01 1.00E00 1.00E00 2-oxoglutarate-dependent dioxygenase activity (GO:0016706) 60 0 .02 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705) 183 1 .05 + 18.74 5.22E-02 1.00E00 dCTP diphosphatase activity (GO:0047840) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702) 24 0 .01 - < 0.01 1.00E00 1.00E00 protein-folding chaperone binding (GO:0051087) 134 0 .04 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen (GO:0016701) 25 0 .01 - < 0.01 1.00E00 1.00E00 butanol dehydrogenase (NAD+) activity (GO:1990362) 1 0 .00 - < 0.01 1.00E00 1.00E00 ligand-modulated transcription factor activity (GO:0098531) 60 0 .02 - < 0.01 1.00E00 1.00E00 unfolded protein binding (GO:0051082) 123 0 .04 - < 0.01 1.00E00 1.00E00 ribose phosphate diphosphokinase activity (GO:0004749) 3 0 .00 - < 0.01 1.00E00 1.00E00 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor (GO:0004748) 3 0 .00 - < 0.01 1.00E00 1.00E00 glycine:proton antiporter activity (GO:0140799) 1 0 .00 - < 0.01 1.00E00 1.00E00 ribokinase activity (GO:0004747) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H3R26 arginine deiminase activity (GO:0140798) 4 0 .00 - < 0.01 1.00E00 1.00E00 histone H3R17 arginine deiminase activity (GO:0140797) 4 0 .00 - < 0.01 1.00E00 1.00E00 all-trans-retinol dehydrogenase (NAD+) activity (GO:0004745) 20 0 .01 - < 0.01 1.00E00 1.00E00 histone H3R8 arginine deiminase activity (GO:0140796) 4 0 .00 - < 0.01 1.00E00 1.00E00 histone H3R2 arginine deiminase activity (GO:0140795) 4 0 .00 - < 0.01 1.00E00 1.00E00 pyruvate kinase activity (GO:0004743) 2 0 .00 - < 0.01 1.00E00 1.00E00 histone arginine deiminase activity (GO:0140794) 4 0 .00 - < 0.01 1.00E00 1.00E00 dihydrolipoyllysine-residue acetyltransferase activity (GO:0004742) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AXY142 phosphatase activity (GO:0140793) 89 0 .03 - < 0.01 1.00E00 1.00E00 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity (GO:0004741) 5 0 .00 - < 0.01 1.00E00 1.00E00 pyruvate dehydrogenase (acetyl-transferring) kinase activity (GO:0004740) 5 0 .00 - < 0.01 1.00E00 1.00E00 histone H2AXS140 phosphatase activity (GO:0140791) 80 0 .02 - < 0.01 1.00E00 1.00E00 D-xylose 1-dehydrogenase (NADP+) activity (GO:0047837) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-sorbitol dehydrogenase (acceptor) activity (GO:0047833) 1 0 .00 - < 0.01 1.00E00 1.00E00 second spliceosomal transesterification activity (GO:0000386) 1 0 .00 - < 0.01 1.00E00 1.00E00 S-adenosyl-L-methionine binding (GO:1904047) 20 0 .01 - < 0.01 1.00E00 1.00E00 death effector domain binding (GO:0035877) 4 0 .00 - < 0.01 1.00E00 1.00E00 pyruvate dehydrogenase (acetyl-transferring) activity (GO:0004739) 3 0 .00 - < 0.01 1.00E00 1.00E00 pyruvate dehydrogenase activity (GO:0004738) 6 0 .00 - < 0.01 1.00E00 1.00E00 histone phosphatase activity (GO:0140789) 135 0 .04 - < 0.01 1.00E00 1.00E00 L-glutamate uniporter activity (GO:0140788) 3 0 .00 - < 0.01 1.00E00 1.00E00 phosphate ion uniporter activity (GO:0140787) 2 0 .00 - < 0.01 1.00E00 1.00E00 pyruvate carboxylase activity (GO:0004736) 1 0 .00 - < 0.01 1.00E00 1.00E00 DNA 5'-adenosine monophosphate hydrolase activity (GO:0033699) 1 0 .00 - < 0.01 1.00E00 1.00E00 pyrroline-5-carboxylate reductase activity (GO:0004735) 4 0 .00 - < 0.01 1.00E00 1.00E00 amino acid sensor activity (GO:0140785) 2 0 .00 - < 0.01 1.00E00 1.00E00 dITP diphosphatase activity (GO:0035870) 2 0 .00 - < 0.01 1.00E00 1.00E00 pyridoxamine phosphate oxidase activity (GO:0004733) 1 0 .00 - < 0.01 1.00E00 1.00E00 metal ion sensor activity (GO:0140784) 23 0 .01 - < 0.01 1.00E00 1.00E00 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor (GO:0033695) 4 0 .00 - < 0.01 1.00E00 1.00E00 purine-nucleoside phosphorylase activity (GO:0004731) 3 0 .00 - < 0.01 1.00E00 1.00E00 D-lysine 5,6-aminomutase activity (GO:0047826) 1 0 .00 - < 0.01 1.00E00 1.00E00 sialic acid binding (GO:0033691) 22 0 .01 - < 0.01 1.00E00 1.00E00 hypotaurine monooxygenase activity (GO:0047822) 6 0 .00 - < 0.01 1.00E00 1.00E00 D-glutamate oxidase activity (GO:0047821) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-glutamate cyclase activity (GO:0047820) 1 0 .00 - < 0.01 1.00E00 1.00E00 oxygen-dependent protoporphyrinogen oxidase activity (GO:0004729) 1 0 .00 - < 0.01 1.00E00 1.00E00 microtubule stabilizing activity (GO:0140778) 1 0 .00 - < 0.01 1.00E00 1.00E00 non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) 88 0 .03 - < 0.01 1.00E00 1.00E00 protein-containing complex stabilizing activity (GO:0140777) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein tyrosine phosphatase activity (GO:0004725) 97 0 .03 - < 0.01 1.00E00 1.00E00 protein-containing complex destabilizing activity (GO:0140776) 16 0 .00 - < 0.01 1.00E00 1.00E00 calcium-dependent protein serine/threonine phosphatase activity (GO:0004723) 82 0 .02 - < 0.01 1.00E00 1.00E00 NAD-dependent protein depalmitoylase activity (GO:0140774) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein serine/threonine phosphatase activity (GO:0004722) 102 0 .03 - < 0.01 1.00E00 1.00E00 NAD-dependent protein demyristoylase activity (GO:0140773) 2 0 .00 - < 0.01 1.00E00 1.00E00 phosphoprotein phosphatase activity (GO:0004721) 174 0 .05 - < 0.01 1.00E00 1.00E00 protein-lysine 6-oxidase activity (GO:0004720) 5 0 .00 - < 0.01 1.00E00 1.00E00 G-rich strand telomeric DNA binding (GO:0098505) 10 0 .00 - < 0.01 1.00E00 1.00E00 NF-kappaB binding (GO:0051059) 32 0 .01 - < 0.01 1.00E00 1.00E00 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity (GO:0004719) 3 0 .00 - < 0.01 1.00E00 1.00E00 protein ADP-ribosyltransferase-substrate adaptor activity (GO:0140768) 4 0 .00 - < 0.01 1.00E00 1.00E00 enzyme-substrate adaptor activity (GO:0140767) 141 0 .04 - < 0.01 1.00E00 1.00E00 3'-5' DNA/RNA helicase activity (GO:0033679) 1 0 .00 - < 0.01 1.00E00 1.00E00 non-membrane spanning protein tyrosine kinase activity (GO:0004715) 45 0 .01 - < 0.01 1.00E00 1.00E00 Krueppel-associated box domain binding (GO:0035851) 2 0 .00 - < 0.01 1.00E00 1.00E00 5'-3' DNA/RNA helicase activity (GO:0033678) 1 0 .00 - < 0.01 1.00E00 1.00E00 transmembrane receptor protein tyrosine kinase activity (GO:0004714) 60 0 .02 - < 0.01 1.00E00 1.00E00 histone H3K56 deacetylase activity, NAD-dependent (GO:0140765) 5 0 .00 - < 0.01 1.00E00 1.00E00 DNA/RNA helicase activity (GO:0033677) 4 0 .00 - < 0.01 1.00E00 1.00E00 protein tyrosine kinase activity (GO:0004713) 140 0 .04 - < 0.01 1.00E00 1.00E00 protein serine/threonine/tyrosine kinase activity (GO:0004712) 43 0 .01 - < 0.01 1.00E00 1.00E00 ribosomal protein S6 kinase activity (GO:0004711) 244 0 .07 - < 0.01 1.00E00 1.00E00 cytidylate cyclase activity (GO:0047805) 1 0 .00 - < 0.01 1.00E00 1.00E00 cysteine-S-conjugate beta-lyase activity (GO:0047804) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-cysteine transaminase activity (GO:0047801) 2 0 .00 - < 0.01 1.00E00 1.00E00 cysteamine dioxygenase activity (GO:0047800) 1 0 .00 - < 0.01 1.00E00 1.00E00 nucleosomal DNA binding (GO:0031492) 41 0 .01 - < 0.01 1.00E00 1.00E00 nucleosome binding (GO:0031491) 73 0 .02 - < 0.01 1.00E00 1.00E00 chromatin DNA binding (GO:0031490) 124 0 .04 - < 0.01 1.00E00 1.00E00 MAP kinase kinase kinase activity (GO:0004709) 27 0 .01 - < 0.01 1.00E00 1.00E00 MAP kinase kinase activity (GO:0004708) 16 0 .00 - < 0.01 1.00E00 1.00E00 histone H3K56 methyltransferase activity (GO:0140759) 9 0 .00 - < 0.01 1.00E00 1.00E00 MAP kinase activity (GO:0004707) 16 0 .00 - < 0.01 1.00E00 1.00E00 JUN kinase kinase kinase activity (GO:0004706) 20 0 .01 - < 0.01 1.00E00 1.00E00 JUN kinase activity (GO:0004705) 14 0 .00 - < 0.01 1.00E00 1.00E00 G protein-coupled receptor kinase activity (GO:0004703) 7 0 .00 - < 0.01 1.00E00 1.00E00 histone octamer slider activity (GO:0140751) 6 0 .00 - < 0.01 1.00E00 1.00E00 nucleosome array spacer activity (GO:0140750) 5 0 .00 - < 0.01 1.00E00 1.00E00 myosin V binding (GO:0031489) 17 0 .00 - < 0.01 1.00E00 1.00E00 RNA 7-methylguanosine cap binding (GO:0000340) 12 0 .00 - < 0.01 1.00E00 1.00E00 RNA transmembrane transporter activity (GO:0051033) 2 0 .00 - < 0.01 1.00E00 1.00E00 nucleic acid transmembrane transporter activity (GO:0051032) 2 0 .00 - < 0.01 1.00E00 1.00E00 phlorizin hydrolase activity (GO:0140749) 1 0 .00 - < 0.01 1.00E00 1.00E00 RNA cap binding (GO:0000339) 20 0 .01 - < 0.01 1.00E00 1.00E00 3-hydroxyanthranilate 3,4-dioxygenase activity (GO:0000334) 1 0 .00 - < 0.01 1.00E00 1.00E00 Rho GDP-dissociation inhibitor binding (GO:0051022) 3 0 .00 - < 0.01 1.00E00 1.00E00 MRF binding (GO:0043426) 5 0 .00 - < 0.01 1.00E00 1.00E00 GDP-dissociation inhibitor binding (GO:0051021) 3 0 .00 - < 0.01 1.00E00 1.00E00 GTPase binding (GO:0051020) 315 0 .09 - < 0.01 1.00E00 1.00E00 bHLH transcription factor binding (GO:0043425) 32 0 .01 - < 0.01 1.00E00 1.00E00 3-phosphoinositide-dependent protein kinase binding (GO:0043423) 1 0 .00 - < 0.01 1.00E00 1.00E00 protein kinase B binding (GO:0043422) 10 0 .00 - < 0.01 1.00E00 1.00E00 mitogen-activated protein kinase binding (GO:0051019) 28 0 .01 - < 0.01 1.00E00 1.00E00 protein kinase A binding (GO:0051018) 53 0 .02 - < 0.01 1.00E00 1.00E00 actin filament binding (GO:0051015) 209 0 .06 - < 0.01 1.00E00 1.00E00 microtubule minus-end binding (GO:0051011) 13 0 .00 - < 0.01 1.00E00 1.00E00 microtubule plus-end binding (GO:0051010) 21 0 .01 - < 0.01 1.00E00 1.00E00 histone H2AS121 kinase activity (GO:0072371) 244 0 .07 - < 0.01 1.00E00 1.00E00 nuclease inhibitor activity (GO:0140721) 6 0 .00 - < 0.01 1.00E00 1.00E00 Hsp27 protein binding (GO:0051008) 1 0 .00 - < 0.01 1.00E00 1.00E00 corticotropin-releasing hormone receptor activity (GO:0043404) 2 0 .00 - < 0.01 1.00E00 1.00E00 structural constituent of egg coat (GO:0035804) 4 0 .00 - < 0.01 1.00E00 1.00E00 deubiquitinase activator activity (GO:0035800) 7 0 .00 - < 0.01 1.00E00 1.00E00 growth hormone activity (GO:0070186) 1 0 .00 - < 0.01 1.00E00 1.00E00 histone chaperone activity (GO:0140713) 13 0 .00 - < 0.01 1.00E00 1.00E00 DNA polymerase binding (GO:0070182) 21 0 .01 - < 0.01 1.00E00 1.00E00 small ribosomal subunit rRNA binding (GO:0070181) 8 0 .00 - < 0.01 1.00E00 1.00E00 large ribosomal subunit rRNA binding (GO:0070180) 6 0 .00 - < 0.01 1.00E00 1.00E00 nicotinamide-nucleotide adenylyltransferase activity (GO:0000309) 3 0 .00 - < 0.01 1.00E00 1.00E00 8-hydroxy-2'-deoxyguanosine DNA binding (GO:1905773) 3 0 .00 - < 0.01 1.00E00 1.00E00 histone H3T3 kinase activity (GO:0072354) 244 0 .07 - < 0.01 1.00E00 1.00E00 L-aspartate N-acetyltransferase activity (GO:0017188) 1 0 .00 - < 0.01 1.00E00 1.00E00 cyclic GMP-AMP binding (GO:0140702) 2 0 .00 - < 0.01 1.00E00 1.00E00 receptor serine/threonine kinase binding (GO:0033612) 30 0 .01 - < 0.01 1.00E00 1.00E00 mitogen-activated protein kinase kinase kinase binding (GO:0031435) 16 0 .00 - < 0.01 1.00E00 1.00E00 mitogen-activated protein kinase kinase binding (GO:0031434) 10 0 .00 - < 0.01 1.00E00 1.00E00 telethonin binding (GO:0031433) 7 0 .00 - < 0.01 1.00E00 1.00E00 titin binding (GO:0031432) 13 0 .00 - < 0.01 1.00E00 1.00E00 modified amino acid transmembrane transporter activity (GO:0072349) 32 0 .01 - < 0.01 1.00E00 1.00E00 NAADP-sensitive calcium-release channel activity (GO:0072345) 5 0 .00 - < 0.01 1.00E00 1.00E00 CCR4-NOT complex binding (GO:1905762) 3 0 .00 - < 0.01 1.00E00 1.00E00 SCF ubiquitin ligase complex binding (GO:1905761) 1 0 .00 - < 0.01 1.00E00 1.00E00 modified amino acid binding (GO:0072341) 89 0 .03 - < 0.01 1.00E00 1.00E00 diphthine-ammonia ligase activity (GO:0017178) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol N-acetylglucosaminyltransferase activity (GO:0017176) 3 0 .00 - < 0.01 1.00E00 1.00E00 glycine N-methyltransferase activity (GO:0017174) 1 0 .00 - < 0.01 1.00E00 1.00E00 cysteine dioxygenase activity (GO:0017172) 1 0 .00 - < 0.01 1.00E00 1.00E00 serine hydrolase activity (GO:0017171) 199 0 .06 - < 0.01 1.00E00 1.00E00 alkali metal ion binding (GO:0031420) 19 0 .01 - < 0.01 1.00E00 1.00E00 CDP-alcohol phosphatidyltransferase activity (GO:0017169) 8 0 .00 - < 0.01 1.00E00 1.00E00 5-oxoprolinase (ATP-hydrolyzing) activity (GO:0017168) 1 0 .00 - < 0.01 1.00E00 1.00E00 vinculin binding (GO:0017166) 12 0 .00 - < 0.01 1.00E00 1.00E00 aryl hydrocarbon receptor binding (GO:0017162) 8 0 .00 - < 0.01 1.00E00 1.00E00 cobalamin binding (GO:0031419) 10 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,3,4-trisphosphate 4-phosphatase activity (GO:0017161) 2 0 .00 - < 0.01 1.00E00 1.00E00 L-ascorbic acid binding (GO:0031418) 20 0 .01 - < 0.01 1.00E00 1.00E00 pantetheine hydrolase activity (GO:0017159) 2 0 .00 - < 0.01 1.00E00 1.00E00 quinine 3-monooxygenase activity (GO:0050591) 1 0 .00 - < 0.01 1.00E00 1.00E00 volume-sensitive chloride channel activity (GO:0072320) 5 0 .00 - < 0.01 1.00E00 1.00E00 semaphorin receptor activity (GO:0017154) 13 0 .00 - < 0.01 1.00E00 1.00E00 sodium:dicarboxylate symporter activity (GO:0017153) 3 0 .00 - < 0.01 1.00E00 1.00E00 DEAD/H-box RNA helicase binding (GO:0017151) 8 0 .00 - < 0.01 1.00E00 1.00E00 tRNA dihydrouridine synthase activity (GO:0017150) 4 0 .00 - < 0.01 1.00E00 1.00E00 carboxylic acid binding (GO:0031406) 186 0 .05 - < 0.01 1.00E00 1.00E00 lipoic acid binding (GO:0031405) 1 0 .00 - < 0.01 1.00E00 1.00E00 chloride ion binding (GO:0031404) 14 0 .00 - < 0.01 1.00E00 1.00E00 lithium ion binding (GO:0031403) 2 0 .00 - < 0.01 1.00E00 1.00E00 sodium ion binding (GO:0031402) 8 0 .00 - < 0.01 1.00E00 1.00E00 structural molecule activity (GO:0005198) 797 0 .23 - < 0.01 1.00E00 1.00E00 4-hydroxymandelate synthase activity (GO:0050585) 1 0 .00 - < 0.01 1.00E00 1.00E00 X11-like protein binding (GO:0042988) 1 0 .00 - < 0.01 1.00E00 1.00E00 SUMO-specific endopeptidase activity (GO:0070139) 5 0 .00 - < 0.01 1.00E00 1.00E00 ubiquitin-like protein-specific endopeptidase activity (GO:0070137) 5 0 .00 - < 0.01 1.00E00 1.00E00 Wnt-protein binding (GO:0017147) 31 0 .01 - < 0.01 1.00E00 1.00E00 acetate ester transmembrane transporter activity (GO:1901375) 4 0 .00 - < 0.01 1.00E00 1.00E00 chondroitin hydrolase activity (GO:0052757) 1 0 .00 - < 0.01 1.00E00 1.00E00 neurohypophyseal hormone activity (GO:0005185) 2 0 .00 - < 0.01 1.00E00 1.00E00 neuropeptide hormone activity (GO:0005184) 31 0 .01 - < 0.01 1.00E00 1.00E00 GDP-mannose hydrolase activity (GO:0052751) 1 0 .00 - < 0.01 1.00E00 1.00E00 gonadotropin hormone-releasing hormone activity (GO:0005183) 2 0 .00 - < 0.01 1.00E00 1.00E00 GDP-L-fucose synthase activity (GO:0050577) 1 0 .00 - < 0.01 1.00E00 1.00E00 ornithine decarboxylase regulator activity (GO:0042979) 5 0 .00 - < 0.01 1.00E00 1.00E00 ornithine decarboxylase activator activity (GO:0042978) 2 0 .00 - < 0.01 1.00E00 1.00E00 1,5-anhydro-D-fructose reductase activity (GO:0050571) 1 0 .00 - < 0.01 1.00E00 1.00E00 peroxisome proliferator activated receptor binding (GO:0042975) 10 0 .00 - < 0.01 1.00E00 1.00E00 mitogen-activated protein kinase p38 binding (GO:0048273) 7 0 .00 - < 0.01 1.00E00 1.00E00 nuclear retinoic acid receptor binding (GO:0042974) 25 0 .01 - < 0.01 1.00E00 1.00E00 histone deacetylase activity, NAD-dependent (GO:0017136) 7 0 .00 - < 0.01 1.00E00 1.00E00 fibroblast growth factor binding (GO:0017134) 23 0 .01 - < 0.01 1.00E00 1.00E00 transforming growth factor beta receptor activity, type III (GO:0070123) 13 0 .00 - < 0.01 1.00E00 1.00E00 methionine adenosyltransferase regulator activity (GO:0048270) 1 0 .00 - < 0.01 1.00E00 1.00E00 poly(C) RNA binding (GO:0017130) 1 0 .00 - < 0.01 1.00E00 1.00E00 heterocyclic compound binding (GO:1901363) 2284 1 .67 + 1.50 5.06E-01 1.00E00 hormone activity (GO:0005179) 133 0 .04 - < 0.01 1.00E00 1.00E00 integrin binding (GO:0005178) 161 0 .05 - < 0.01 1.00E00 1.00E00 inositol phosphate phosphatase activity (GO:0052745) 20 0 .01 - < 0.01 1.00E00 1.00E00 phosphatidylinositol monophosphate phosphatase activity (GO:0052744) 18 0 .01 - < 0.01 1.00E00 1.00E00 ErbB-2 class receptor binding (GO:0005176) 3 0 .00 - < 0.01 1.00E00 1.00E00 inositol tetrakisphosphate phosphatase activity (GO:0052743) 8 0 .00 - < 0.01 1.00E00 1.00E00 CD27 receptor binding (GO:0005175) 1 0 .00 - < 0.01 1.00E00 1.00E00 phosphatidylinositol kinase activity (GO:0052742) 26 0 .01 - < 0.01 1.00E00 1.00E00 CD40 receptor binding (GO:0005174) 2 0 .00 - < 0.01 1.00E00 1.00E00 (R)-limonene 6-monooxygenase activity (GO:0052741) 2 0 .00 - < 0.01 1.00E00 1.00E00 protein-glutamine glutaminase activity (GO:0050568) 1 0 .00 - < 0.01 1.00E00 1.00E00 stem cell factor receptor binding (GO:0005173) 4 0 .00 - < 0.01 1.00E00 1.00E00 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity (GO:0050567) 3 0 .00 - < 0.01 1.00E00 1.00E00 vascular endothelial growth factor receptor binding (GO:0005172) 13 0 .00 - < 0.01 1.00E00 1.00E00 hepatocyte growth factor receptor binding (GO:0005171) 2 0 .00 - < 0.01 1.00E00 1.00E00 neurotrophin TRKC receptor binding (GO:0005170) 1 0 .00 - < 0.01 1.00E00 1.00E00 triglyceride binding (GO:0017129) 4 0 .00 - < 0.01 1.00E00 1.00E00 ciliary neurotrophic factor binding (GO:0070119) 1 0 .00 - < 0.01 1.00E00 1.00E00 glutamate-tRNA(Gln) ligase activity (GO:0050561) 1 0 .00 - < 0.01 1.00E00 1.00E00 phospholipid scramblase activity (GO:0017128) 21 0 .01 - < 0.01 1.00E00 1.00E00 aspartate-tRNA(Asn) ligase activity (GO:0050560) 1 0 .00 - < 0.01 1.00E00 1.00E00 deoxycytidyl transferase activity (GO:0017125) 1 0 .00 - < 0.01 1.00E00 1.00E00 SH3 domain binding (GO:0017124) 115 0 .03 - < 0.01 1.00E00 1.00E00 neurotrophin TRKB receptor binding (GO:0005169) 1 0 .00 - < 0.01 1.00E00 1.00E00 neurotrophin TRKA receptor binding (GO:0005168) 6 0 .00 - < 0.01 1.00E00 1.00E00 tRNA (cytidine-3-)-methyltransferase activity (GO:0052735) 4 0 .00 - < 0.01 1.00E00 1.00E00 neurotrophin TRK receptor binding (GO:0005167) 6 0 .00 - < 0.01 1.00E00 1.00E00 neurotrophin p75 receptor binding (GO:0005166) 1 0 .00 - < 0.01 1.00E00 1.00E00 neurotrophin receptor binding (GO:0005165) 12 0 .00 - < 0.01 1.00E00 1.00E00 phosphoethanolamine phosphatase activity (GO:0052732) 2 0 .00 - < 0.01 1.00E00 1.00E00 tumor necrosis factor receptor binding (GO:0005164) 31 0 .01 - < 0.01 1.00E00 1.00E00 phosphocholine phosphatase activity (GO:0052731) 1 0 .00 - < 0.01 1.00E00 1.00E00 nerve growth factor receptor binding (GO:0005163) 5 0 .00 - < 0.01 1.00E00 1.00E00 platelet-derived growth factor receptor binding (GO:0005161) 14 0 .00 - < 0.01 1.00E00 1.00E00 transforming growth factor beta receptor binding (GO:0005160) 26 0 .01 - < 0.01 1.00E00 1.00E00 3'-flap endonuclease activity (GO:0048257) 1 0 .00 - < 0.01 1.00E00 1.00E00 flap endonuclease activity (GO:0048256) 8 0 .00 - < 0.01 1.00E00 1.00E00 lipoyltransferase activity (GO:0017118) 1 0 .00 - < 0.01 1.00E00 1.00E00 single-stranded DNA helicase activity (GO:0017116) 58 0 .02 - < 0.01 1.00E00 1.00E00 dihydropyrimidine dehydrogenase (NADP+) activity (GO:0017113) 1 0 .00 - < 0.01 1.00E00 1.00E00 ribonucleoside triphosphate phosphatase activity (GO:0017111) 746 0 .22 - < 0.01 1.00E00 1.00E00 nucleoside diphosphate phosphatase activity (GO:0017110) 17 0 .00 - < 0.01 1.00E00 1.00E00 insulin-like growth factor receptor binding (GO:0005159) 16 0 .00 - < 0.01 1.00E00 1.00E00 insulin receptor binding (GO:0005158) 23 0 .01 - < 0.01 1.00E00 1.00E00 inositol-1,3,4-trisphosphate 5-kinase activity (GO:0052726) 1 0 .00 - < 0.01 1.00E00 1.00E00 macrophage colony-stimulating factor receptor binding (GO:0005157) 3 0 .00 - < 0.01 1.00E00 1.00E00 inositol-1,3,4-trisphosphate 6-kinase activity (GO:0052725) 1 0 .00 - < 0.01 1.00E00 1.00E00 inositol hexakisphosphate 1-kinase activity (GO:0052723) 4 0 .00 - < 0.01 1.00E00 1.00E00 fatty acid in-chain hydroxylase activity (GO:0052722) 1 0 .00 - < 0.01 1.00E00 1.00E00 epidermal growth factor receptor binding (GO:0005154) 35 0 .01 - < 0.01 1.00E00 1.00E00 interleukin-8 receptor binding (GO:0005153) 3 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-1 receptor antagonist activity (GO:0005152) 3 0 .00 - < 0.01 1.00E00 1.00E00 class II DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0052720) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-1, type II receptor binding (GO:0005151) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-1, type I receptor binding (GO:0005150) 2 0 .00 - < 0.01 1.00E00 1.00E00 arachidonate binding (GO:0050544) 7 0 .00 - < 0.01 1.00E00 1.00E00 CXCR3 chemokine receptor binding (GO:0048248) 5 0 .00 - < 0.01 1.00E00 1.00E00 icosatetraenoic acid binding (GO:0050543) 7 0 .00 - < 0.01 1.00E00 1.00E00 icosanoid binding (GO:0050542) 8 0 .00 - < 0.01 1.00E00 1.00E00 glucoside transmembrane transporter activity (GO:0042947) 3 0 .00 - < 0.01 1.00E00 1.00E00 5'-flap endonuclease activity (GO:0017108) 7 0 .00 - < 0.01 1.00E00 1.00E00 phytanoyl-CoA dioxygenase activity (GO:0048244) 1 0 .00 - < 0.01 1.00E00 1.00E00 D-amino acid transmembrane transporter activity (GO:0042943) 1 0 .00 - < 0.01 1.00E00 1.00E00 catecholamine binding (GO:1901338) 13 0 .00 - < 0.01 1.00E00 1.00E00 tRNA-specific adenosine-34 deaminase activity (GO:0052717) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-1 receptor binding (GO:0005149) 16 0 .00 - < 0.01 1.00E00 1.00E00 prolactin receptor binding (GO:0005148) 2 0 .00 - < 0.01 1.00E00 1.00E00 oncostatin-M receptor binding (GO:0005147) 1 0 .00 - < 0.01 1.00E00 1.00E00 kininogen binding (GO:0030984) 1 0 .00 - < 0.01 1.00E00 1.00E00 leukemia inhibitory factor receptor binding (GO:0005146) 2 0 .00 - < 0.01 1.00E00 1.00E00 mismatched DNA binding (GO:0030983) 14 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-13 receptor binding (GO:0005144) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-12 receptor binding (GO:0005143) 5 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-11 receptor binding (GO:0005142) 1 0 .00 - < 0.01 1.00E00 1.00E00 ATP:ATP adenylyltransferase activity (GO:0141192) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-10 receptor binding (GO:0005141) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-9 receptor binding (GO:0005140) 1 0 .00 - < 0.01 1.00E00 1.00E00 tripeptide transmembrane transporter activity (GO:0042937) 9 0 .00 - < 0.01 1.00E00 1.00E00 deaminated glutathione amidase activity (GO:0110050) 1 0 .00 - < 0.01 1.00E00 1.00E00 enterobactin transmembrane transporter activity (GO:0042931) 1 0 .00 - < 0.01 1.00E00 1.00E00 bicarbonate binding (GO:0071890) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-7 receptor binding (GO:0005139) 2 0 .00 - < 0.01 1.00E00 1.00E00 taurine binding (GO:0030977) 1 0 .00 - < 0.01 1.00E00 1.00E00 thiamine pyrophosphate binding (GO:0030976) 8 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-6 receptor binding (GO:0005138) 7 0 .00 - < 0.01 1.00E00 1.00E00 thiamine binding (GO:0030975) 1 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-5 receptor binding (GO:0005137) 2 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-4 receptor binding (GO:0005136) 3 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-3 receptor binding (GO:0005135) 2 0 .00 - < 0.01 1.00E00 1.00E00 UFM1-modified protein reader activity (GO:0141185) 3 0 .00 - < 0.01 1.00E00 1.00E00 interleukin-2 receptor binding (GO:0005134) 5 0 .00 - < 0.01 1.00E00 1.00E00 receptor tyrosine kinase binding (GO:0030971) 81 0 .02 - < 0.01 1.00E00 1.00E00 type II interferon receptor binding (GO:0005133) 2 0 .00 - < 0.01 1.00E00 1.00E00 acyloxyacyl hydrolase activity (GO:0050528) 1 0 .00 - < 0.01 1.00E00 1.00E00 type I interferon receptor binding (GO:0005132) 16 0 .00 - < 0.01 1.00E00 1.00E00