RID: 6A45367B016 Job Title:Q65EX3:RecName: Full=Cyclo(L-leucyl-L-leucyl)... Program: BLASTP Query: RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName: Full=Cyclodileucine synthase; AltName: Full=Cyclodipeptide synthase; Short=CDPS [Bacillus licheniformis DSM 13 = ATCC 14580] ID: Q65EX3.1(amino acid) Length: 249 Database: swissprot Non-redundant UniProtKB/SwissProt sequences Sequences producing significant alignments: Scientific Common Max Total Query E Per. Acc. Description Name Name Taxid Score Score cover Value Ident Len Accession RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName:... Bacillus lic... NA 279010 514 514 100% 0.0 100.00 249 Q65EX3.1 RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName:... Bacillus sub... NA 224308 356 356 99% 1e-124 70.45 248 O34351.1 RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName:... Staphylococc... NA 279808 209 209 92% 5e-67 42.06 234 Q4L2X9.1 RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName:... Photorhabdus... NA 243265 160 160 89% 7e-48 35.11 234 Q7N9M5.1 RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName:... Corynebacter... NA 306537 124 124 85% 7e-34 33.03 216 Q4JVS0.1 RecName: Full=Cyclo(L-leucyl-L-phenylalanyl) synthase; AltName... Streptomyces... NA 1971 90.5 90.5 93% 9e-21 28.63 239 Q8GED7.1 RecName: Full=Cyclo(L-tyrosyl-L-tyrosyl) synthase; AltName:... Mycobacteriu... NA 83331 82.0 82.0 88% 3e-17 27.11 289 P9WPF8.1 Alignments: >RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName: Full=Cyclodileucine synthase; AltName: Full=Cyclodipeptide synthase; Short=CDPS [Bacillus licheniformis DSM 13 = ATCC 14580] Sequence ID: Q65EX3.1 Length: 249 Range 1: 1 to 249 Score:514 bits(1324), Expect:0.0, Method:Compositional matrix adjust., Identities:249/249(100%), Positives:249/249(100%), Gaps:0/249(0%) Query 1 MTELIMESKHQLFKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQ 60 MTELIMESKHQLFKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQ Sbjct 1 MTELIMESKHQLFKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQ 60 Query 61 SVSVLLAGKEAANLLEALGTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPEDIHTFSDF 120 SVSVLLAGKEAANLLEALGTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPEDIHTFSDF Sbjct 61 SVSVLLAGKEAANLLEALGTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPEDIHTFSDF 120 Query 121 ANQTAYRNLRMEVEAAFFDQTHFRNACLEMSHAAILGRARGTRMDVVEVSADMLELAVEY 180 ANQTAYRNLRMEVEAAFFDQTHFRNACLEMSHAAILGRARGTRMDVVEVSADMLELAVEY Sbjct 121 ANQTAYRNLRMEVEAAFFDQTHFRNACLEMSHAAILGRARGTRMDVVEVSADMLELAVEY 180 Query 181 VIAELPFFIAAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMVSEADERVE 240 VIAELPFFIAAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMVSEADERVE Sbjct 181 VIAELPFFIAAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMVSEADERVE 240 Query 241 SKSMQEERV 249 SKSMQEERV Sbjct 241 SKSMQEERV 249 >RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName: Full=Cyclodileucine synthase; AltName: Full=Cyclodipeptide synthase; Short=CDPS [Bacillus subtilis subsp. subtilis str. 168] Sequence ID: O34351.1 Length: 248 Range 1: 1 to 247 Score:356 bits(914), Expect:1e-124, Method:Compositional matrix adjust., Identities:174/247(70%), Positives:201/247(81%), Gaps:0/247(0%) Query 1 MTELIMESKHQLFKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQ 60 MT ++ E + F E LT+NC EI +RRRHVLVGISPFNSRFSEDYI+RLI WA +F+ Sbjct 1 MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFSEDYIYRLIGWAKAQFK 60 Query 61 SVSVLLAGKEAANLLEALGTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPEDIHTFSDF 120 SVSVLLAG EAANLLEALGTP GKAERKVRKEVSRNRRFAE+AL AHGG+P+ IHTFSDF Sbjct 61 SVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAERALVAHGGDPKAIHTFSDF 120 Query 121 ANQTAYRNLRMEVEAAFFDQTHFRNACLEMSHAAILGRARGTRMDVVEVSADMLELAVEY 180 + AY+ LR EVE AFF+Q HFR+ACL+MS AI+GRARG + + EVS DML LAVEY Sbjct 121 IDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRARGVSLMMEEVSEDMLNLAVEY 180 Query 181 VIAELPFFIAAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMVSEADERVE 240 VIAELPFFI APDIL VEETLLAYHRPWKLGE+IS +EF++ MRPNQGYL+V E + + Sbjct 181 VIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHEFSICMRPNQGYLIVQEMAQMLS 240 Query 241 SKSMQEE 247 K + E Sbjct 241 EKRITSE 247 >RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName: Full=Cyclodileucine synthase; AltName: Full=Cyclodipeptide synthase; Short=CDPS [Staphylococcus haemolyticus JCSC1435] Sequence ID: Q4L2X9.1 Length: 234 Range 1: 2 to 233 Score:209 bits(533), Expect:5e-67, Method:Compositional matrix adjust., Identities:98/233(42%), Positives:150/233(64%), Gaps:3/233(1%) Query 11 QLFKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQSVSVLLAGKE 70 Q FK + LT+NC +I +R++HV++GISPF S+++E YI ++I WA F S+LLAG+E Sbjct 2 QNFKVDFLTKNCKQIYQRKKHVILGISPFTSKYNESYIRKIIQWANSNFDDFSILLAGEE 61 Query 71 AANLLEALGTPHGKAERKVRKEVSRNRRFAE-KALEAHGGNPEDIHTFSDFANQTAYRNL 129 + NLLE LG KA +KVRKE+ R RF E + ++ + IH FSDF N Y ++ Sbjct 62 SKNLLECLGYSSSKANQKVRKEIKRQIRFCEDEIIKCNKTITNRIHRFSDFKNNIYYIDI 121 Query 130 RMEVEAAFFDQTHFRNACLEMSHAAILGRARGTRMDVVEVSADMLELAVEYVIAELPFFI 189 + F ++F+N+CL+MS A+ + + +E++ + LE A +YV+AELPFF+ Sbjct 122 YKTIVDQFNTDSNFKNSCLKMSLQALQSKGKNVNTS-IEITDETLEYAAQYVLAELPFFL 180 Query 190 AAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMVSE-ADERVES 241 A I+ +ETL+AYH PW+LG I ++F +KM QGY++++E D V+S Sbjct 181 NANPIINTQETLMAYHAPWELGTNIINDQFNLKMNEKQGYIILTEKGDNYVKS 233 >RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName: Full=Cyclodileucine synthase; AltName: Full=Cyclodipeptide synthase; Short=CDPS [Photorhabdus laumondii subsp. laumondii TTO1] Sequence ID: Q7N9M5.1 Length: 234 Range 1: 9 to 233 Score:160 bits(406), Expect:7e-48, Method:Compositional matrix adjust., Identities:79/225(35%), Positives:133/225(59%), Gaps:3/225(1%) Query 13 FKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQSVSVLLAG-KEA 71 F + T C++I+++ H L+GISPFNSRFS+DY+ LI W+ F+ V +LL +EA Sbjct 9 FTVQGETSRCDQIIQKGDHALIGISPFNSRFSKDYVVDLIQWSSHYFRQVDILLPCEREA 68 Query 72 ANLLEALGTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPEDIHT--FSDFANQTAYRNL 129 + LL A G + KA +K +E+ R+ R + + + I FSDF+ Y++L Sbjct 69 SRLLVASGIDNVKAIKKTHREIRRHLRNLDYVISTATLKSKQIRVIQFSDFSLNHDYQSL 128 Query 130 RMEVEAAFFDQTHFRNACLEMSHAAILGRARGTRMDVVEVSADMLELAVEYVIAELPFFI 189 + +VE AF + F+ +CL+MS AI GR +GT ++ ++ A+ Y+ AE+PF++ Sbjct 129 KTQVENAFNESESFKKSCLDMSFQAIKGRLKGTGQYFGQIDLQLVYKALPYIFAEIPFYL 188 Query 190 AAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMVSE 234 P +LGV+ + L YHRPW +G+ + + +++ Q Y +V++ Sbjct 189 NTPRLLGVKYSTLLYHRPWSIGKGLFNGSYPIQVADKQSYGIVTQ 233 >RecName: Full=Cyclo(L-leucyl-L-leucyl) synthase; AltName: Full=Cyclodileucine synthase; AltName: Full=Cyclodipeptide synthase; Short=CDPS [Corynebacterium jeikeium K411] Sequence ID: Q4JVS0.1 Length: 216 Range 1: 5 to 215 Score:124 bits(312), Expect:7e-34, Method:Compositional matrix adjust., Identities:72/218(33%), Positives:115/218(52%), Gaps:12/218(5%) Query 28 RRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQSVSVLLAGKEAANLLEALGTPHGKAER 87 ++ H++VG+SPFN RF+ +++ W F +V VL G+ + +LL + GTP G+A+R Sbjct 5 KQEHLIVGVSPFNPRFTPEWLSSAFQWGAERFNTVDVLHPGEISMSLLTSTGTPLGRAKR 64 Query 88 KVRKEVSRNRRFAEKALEAHG-----GNPEDIHTFSDFANQTAYRNLRMEVEAAFFDQTH 142 KVR++ +R+ R E ALE G G P I SD+ +Y+ R V A F + Sbjct 65 KVRQQCNRDMRNVEHALEISGIKLGRGKPVLI---SDYLQTQSYQCRRRSVIAEFQNNQI 121 Query 143 FRNACLEMSHAAILGRARGTRMDVVEVSADMLELAVEYVIAELPFFIAAPDILGVEETLL 202 F++AC MS AA R R T V + D +E AV+Y+ ELP + D+ E L Sbjct 122 FQDACRAMSRAACQSRLRVTN---VNIEPD-IETAVKYIFDELPAYTHCSDLFEYETAAL 177 Query 203 AYHRPWKLGEQISRNEFAVKMRPNQGYLMVSEADERVE 240 Y W +G+ I +++ PN ++++ E ++ Sbjct 178 GYPTEWPIGKLIESGLTSLERDPNSSFIVIDFEKELID 215 >RecName: Full=Cyclo(L-leucyl-L-phenylalanyl) synthase; AltName: Full=Cyclodipeptide synthase; Short=CDPS [Streptomyces noursei] Sequence ID: Q8GED7.1 Length: 239 Range 1: 2 to 230 Score:90.5 bits(223), Expect:9e-21, Method:Compositional matrix adjust., Identities:67/234(29%), Positives:109/234(46%), Gaps:7/234(2%) Query 1 MTELIMESKHQLFKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQ 60 + L+ H + + E L I +R H L+GIS NS FS+ L+ WA + F+ Sbjct 2 LAGLVPAPDHGM-REEILGDRSRLIRQRGEHALIGISAGNSYFSQKNTVMLLQWAGQRFE 60 Query 61 SVSVLLAGKEAANLLEALGTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPE--DIHTFS 118 V+ +L A G +AER V++ + RR ++LE+ G + E + + S Sbjct 61 RTDVVYVDTHIDEMLIADGRSAQEAERSVKRTLKDLRRRLRRSLESVGDHAERFRVRSLS 120 Query 119 DFANQTAYRNLRMEVEAAFFDQTHFRNACLEMSHAAILGRARGTRMDVVEVSADMLELAV 178 + YR +R + AF + F AC +M A ++ R D V +SA+ L + Sbjct 121 ELQETPEYRAVRERTDRAFEEDAEFATACEDMVRAVVMNRP----GDGVGISAEHLRAGL 176 Query 179 EYVIAELPFFIAAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMV 232 YV+AE P F +P + V ++L YH + +SR E + Q Y++V Sbjct 177 NYVLAEAPLFADSPGVFSVPSSVLCYHIDTPITAFLSRRETGFRAAEGQAYVVV 230 >RecName: Full=Cyclo(L-tyrosyl-L-tyrosyl) synthase; AltName: Full=Cyclodipeptide synthase; Short=CDPS; AltName: Full=Cyclodityrosine synthase [Mycobacterium tuberculosis CDC1551] Sequence ID: P9WPF8.1 Length: 289 >RecName: Full=Cyclo(L-tyrosyl-L-tyrosyl) synthase; AltName: Full=Cyclodipeptide synthase; Short=CDPS; AltName: Full=Cyclodityrosine synthase [Mycobacterium tuberculosis H37Rv] Sequence ID: P9WPF9.1 Length: 289 Range 1: 64 to 282 Score:82.0 bits(201), Expect:3e-17, Method:Compositional matrix adjust., Identities:61/225(27%), Positives:94/225(41%), Gaps:10/225(4%) Query 13 FKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQSVSVLLAGKEAA 72 F TQ C I H ++G+SP NS FS + L W + F V + A Sbjct 64 FLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVA 123 Query 73 NLLEALGTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPED----IHTFSDFANQTAYRN 128 EALG +A RK K + R A+ + +P + S+F + AYR Sbjct 124 ESYEALGDSAIEARRKAVKNIRGVR--AKITTTVNELDPAGARLCVRPMSEFQSNEAYRE 181 Query 129 LRMEVEAAFFDQTHFRNACLEMSHAAILGRARGTRMDVVEVSADMLELAVEYVIAELPFF 188 L ++ D R C ++ L G R +A ++ ++Y+ AE P F Sbjct 182 LHADLLTRLKDDEDLRAVCQDLVR-RFLSTKVGPRQG---ATATQEQVCMDYICAEAPLF 237 Query 189 IAAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMVS 233 + P ILGV +L YH+ L E + ++ NQG+ +V+ Sbjct 238 LDTPAILGVPSSLNCYHQSLPLAEMLYARGSGLRASRNQGHAIVT 282