| Image | 3D structure | Amount of sequences | Description |
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2639 | Contains only one domain. |
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677 | Pleckstrin homology domain function:
This domain can bind phosphatidylinositol lipids within biological membranes and proteins. Through different interactions, PH domain plays an important role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. |
Chosen taxon: Eukaryota
Chosen subtaxa: Fungi, Metazoa
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Using the third .py script and Jalview,
I was able to create .jvp file with 2 groups (as for 2 domain architectures) with 40 seqeunces (20 from Fungi, 20 from Metazoa) in each of them.
A part of my alignment
Download Jalview alignment
Even from the picture above could be noticed that the second group sequences are more conservative (conservation threshold was set to 100% for both groups).
What is more, many conservative columns from the first group and the second are the same because of a similar structure.
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WIth coloured lines I marked similar groups, sometimes clades (e.g light green M, which is next to light blue F). A division by domain architecures is not strict, but quite discernible: left part is almost all 1, while the right contains mostly 2's, it means that the architectures were formed before taxons because there is no strict division (left-right i mean) in Metazoa-Fungi taxons.
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