Analysis Type: PANTHER Overrepresentation Test (Released 20240226) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.10536401 Released 2024-01-17 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO biological process complete Homo sapiens - REFLIST (20592) upload_1 (46) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) tryptophan catabolic process (GO:0006569) 9 9 .02 + > 100 6.02E-25 4.17E-22 indole-containing compound catabolic process (GO:0042436) 9 9 .02 + > 100 6.02E-25 3.99E-22 tryptophan catabolic process to kynurenine (GO:0019441) 5 5 .01 + > 100 4.44E-14 1.69E-11 response to polycyclic arene (GO:1903165) 2 2 .00 + > 100 4.88E-06 5.60E-04 anthranilate metabolic process (GO:0043420) 3 3 .01 + > 100 1.04E-08 1.69E-06 response to 3-methylcholanthrene (GO:1904681) 2 2 .00 + > 100 4.88E-06 5.55E-04 indole-containing compound biosynthetic process (GO:0042435) 5 5 .01 + > 100 4.44E-14 1.65E-11 serotonin biosynthetic process (GO:0042427) 3 3 .01 + > 100 1.04E-08 1.67E-06 quinolinate biosynthetic process (GO:0019805) 3 3 .01 + > 100 1.04E-08 1.66E-06 melatonin biosynthetic process (GO:0030187) 2 2 .00 + > 100 4.88E-06 5.51E-04 melatonin metabolic process (GO:0030186) 2 2 .00 + > 100 4.88E-06 5.47E-04 'de novo' NAD biosynthetic process from tryptophan (GO:0034354) 6 6 .01 + > 100 8.85E-17 4.22E-14 L-kynurenine catabolic process (GO:0097053) 4 4 .01 + > 100 2.18E-11 6.04E-09 kynurenic acid biosynthetic process (GO:0034276) 2 2 .00 + > 100 4.88E-06 5.43E-04 kynurenic acid metabolic process (GO:0034275) 2 2 .00 + > 100 4.88E-06 5.39E-04 indolalkylamine biosynthetic process (GO:0046219) 2 2 .00 + > 100 4.88E-06 5.35E-04 indolalkylamine metabolic process (GO:0006586) 13 12 .03 + > 100 4.18E-32 7.07E-29 tryptophan metabolic process (GO:0006568) 11 10 .02 + > 100 1.19E-26 1.13E-23 kynurenine metabolic process (GO:0070189) 11 10 .02 + > 100 1.19E-26 1.06E-23 'de novo' NAD biosynthetic process (GO:0034627) 7 6 .02 + > 100 6.19E-16 2.77E-13 L-kynurenine metabolic process (GO:0097052) 7 6 .02 + > 100 6.19E-16 2.69E-13 quinolinate metabolic process (GO:0046874) 4 3 .01 + > 100 4.17E-08 6.29E-06 L-lysine catabolic process to acetyl-CoA via saccharopine (GO:0033512) 3 2 .01 + > 100 1.46E-05 1.47E-03 indole-containing compound metabolic process (GO:0042430) 23 15 .05 + > 100 6.42E-36 4.90E-32 primary amino compound biosynthetic process (GO:1901162) 5 3 .01 + > 100 1.04E-07 1.51E-05 aromatic amino acid family catabolic process (GO:0009074) 16 9 .04 + > 100 6.80E-21 3.84E-18 L-lysine catabolic process (GO:0019477) 4 2 .01 + > 100 2.92E-05 2.84E-03 L-lysine catabolic process to acetyl-CoA (GO:0019474) 4 2 .01 + > 100 2.92E-05 2.82E-03 dibenzo-p-dioxin metabolic process (GO:0018894) 4 2 .01 + > 100 2.92E-05 2.80E-03 protein succinylation (GO:0018335) 4 2 .01 + > 100 2.92E-05 2.78E-03 histone succinylation (GO:0106077) 4 2 .01 + > 100 2.92E-05 2.77E-03 9-cis-retinoic acid metabolic process (GO:0042905) 4 2 .01 + > 100 2.92E-05 2.75E-03 9-cis-retinoic acid biosynthetic process (GO:0042904) 4 2 .01 + > 100 2.92E-05 2.73E-03 L-lysine metabolic process (GO:0046440) 4 2 .01 + > 100 2.92E-05 2.71E-03 benzene-containing compound metabolic process (GO:0042537) 26 12 .06 + > 100 3.04E-26 2.44E-23 aromatic amino acid metabolic process (GO:0009072) 31 12 .07 + > 100 4.41E-25 3.20E-22 amino-acid betaine biosynthetic process (GO:0006578) 6 2 .01 + > 100 7.28E-05 6.45E-03 hydrogen peroxide biosynthetic process (GO:0050665) 10 3 .02 + > 100 1.24E-06 1.64E-04 serotonin metabolic process (GO:0042428) 10 3 .02 + > 100 1.24E-06 1.63E-04 lysine catabolic process (GO:0006554) 7 2 .02 + > 100 1.02E-04 8.62E-03 primary amino compound metabolic process (GO:1901160) 14 4 .03 + > 100 2.15E-08 3.34E-06 omega-hydroxylase P450 pathway (GO:0097267) 11 3 .02 + > 100 1.70E-06 2.20E-04 lysine metabolic process (GO:0006553) 8 2 .02 + > 100 1.36E-04 1.12E-02 retinoic acid biosynthetic process (GO:0002138) 8 2 .02 + > 100 1.36E-04 1.12E-02 dicarboxylic acid biosynthetic process (GO:0043650) 12 3 .03 + > 100 2.26E-06 2.80E-04 ketone catabolic process (GO:0042182) 16 4 .04 + > 100 3.89E-08 5.93E-06 NAD biosynthetic process (GO:0009435) 25 6 .06 + > 100 1.52E-11 4.29E-09 pyridine-containing compound biosynthetic process (GO:0072525) 31 7 .07 + > 100 4.35E-13 1.54E-10 non-proteinogenic amino acid catabolic process (GO:0170044) 18 4 .04 + 99.48 6.52E-08 9.64E-06 diterpenoid biosynthetic process (GO:0016102) 9 2 .02 + 99.48 1.74E-04 1.42E-02 pyridine nucleotide biosynthetic process (GO:0019363) 27 6 .06 + 99.48 2.53E-11 6.65E-09 nicotinamide nucleotide biosynthetic process (GO:0019359) 27 6 .06 + 99.48 2.53E-11 6.54E-09 catecholamine catabolic process (GO:0042424) 10 2 .02 + 89.53 2.17E-04 1.70E-02 dopamine catabolic process (GO:0042420) 10 2 .02 + 89.53 2.17E-04 1.69E-02 catechol-containing compound catabolic process (GO:0019614) 10 2 .02 + 89.53 2.17E-04 1.68E-02 toxin metabolic process (GO:0009404) 15 3 .03 + 89.53 4.66E-06 5.38E-04 amino-acid betaine metabolic process (GO:0006577) 16 3 .04 + 83.93 5.72E-06 6.19E-04 amide catabolic process (GO:0043605) 16 3 .04 + 83.93 5.72E-06 6.14E-04 amine metabolic process (GO:0009308) 102 19 .23 + 83.39 1.01E-32 1.92E-29 ammonium ion metabolic process (GO:0097164) 22 4 .05 + 81.39 1.55E-07 2.23E-05 2-oxoglutarate metabolic process (GO:0006103) 17 3 .04 + 79.00 6.94E-06 7.40E-04 reactive oxygen species biosynthetic process (GO:1903409) 17 3 .04 + 79.00 6.94E-06 7.35E-04 alpha-amino acid catabolic process (GO:1901606) 87 15 .19 + 77.18 3.15E-25 2.40E-22 acetyl-CoA metabolic process (GO:0006084) 29 5 .06 + 77.18 5.07E-09 9.20E-07 biogenic amine metabolic process (GO:0006576) 93 16 .21 + 77.02 6.84E-27 6.95E-24 epoxygenase P450 pathway (GO:0019373) 18 3 .04 + 74.61 8.32E-06 8.68E-04 phenol-containing compound catabolic process (GO:0019336) 12 2 .03 + 74.61 3.18E-04 2.35E-02 fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) 12 2 .03 + 74.61 3.18E-04 2.34E-02 ethanol catabolic process (GO:0006068) 12 2 .03 + 74.61 3.18E-04 2.33E-02 carnitine metabolic process (GO:0009437) 12 2 .03 + 74.61 3.18E-04 2.32E-02 amino acid catabolic process (GO:0009063) 108 17 .24 + 70.46 7.10E-28 8.33E-25 aspartate family amino acid catabolic process (GO:0009068) 13 2 .03 + 68.87 3.75E-04 2.68E-02 amine catabolic process (GO:0009310) 20 3 .04 + 67.15 1.16E-05 1.18E-03 cellular biogenic amine catabolic process (GO:0042402) 20 3 .04 + 67.15 1.16E-05 1.18E-03 non-proteinogenic amino acid metabolic process (GO:0170041) 69 10 .15 + 64.88 3.35E-16 1.55E-13 acetyl-CoA biosynthetic process (GO:0006085) 14 2 .03 + 63.95 4.37E-04 3.11E-02 branched-chain amino acid catabolic process (GO:0009083) 22 3 .05 + 61.04 1.56E-05 1.54E-03 fatty acid beta-oxidation (GO:0006635) 60 8 .13 + 59.69 7.66E-13 2.65E-10 terpenoid biosynthetic process (GO:0016114) 15 2 .03 + 59.69 5.03E-04 3.52E-02 primary alcohol catabolic process (GO:0034310) 15 2 .03 + 59.69 5.03E-04 3.50E-02 hydrogen peroxide metabolic process (GO:0042743) 41 5 .09 + 54.59 3.14E-08 4.83E-06 L-amino acid catabolic process (GO:0170035) 58 7 .13 + 54.03 4.75E-11 1.17E-08 response to vitamin A (GO:0033189) 17 2 .04 + 52.66 6.50E-04 4.44E-02 response to corticosterone (GO:0051412) 17 2 .04 + 52.66 6.50E-04 4.42E-02 cellular ketone metabolic process (GO:0042180) 88 10 .20 + 50.87 4.31E-15 1.83E-12 retinal metabolic process (GO:0042574) 18 2 .04 + 49.74 7.30E-04 4.88E-02 regulation of catecholamine metabolic process (GO:0042069) 18 2 .04 + 49.74 7.30E-04 4.86E-02 regulation of dopamine metabolic process (GO:0042053) 18 2 .04 + 49.74 7.30E-04 4.84E-02 branched-chain amino acid metabolic process (GO:0009081) 28 3 .06 + 47.96 3.29E-05 3.04E-03 organic acid catabolic process (GO:0016054) 232 24 .52 + 46.31 3.29E-35 1.67E-31 carboxylic acid catabolic process (GO:0046395) 232 24 .52 + 46.31 3.29E-35 1.25E-31 dopamine metabolic process (GO:0042417) 31 3 .07 + 43.32 4.49E-05 4.10E-03 NAD metabolic process (GO:0019674) 62 6 .14 + 43.32 4.96E-09 9.10E-07 fatty acid oxidation (GO:0019395) 84 8 .19 + 42.63 1.25E-11 3.61E-09 regulation of amine metabolic process (GO:0033238) 32 3 .07 + 41.97 4.94E-05 4.46E-03 lipid oxidation (GO:0034440) 90 8 .20 + 39.79 2.21E-11 6.01E-09 fatty acid catabolic process (GO:0009062) 91 8 .20 + 39.35 2.42E-11 6.46E-09 cellular aldehyde metabolic process (GO:0006081) 69 6 .15 + 38.93 9.55E-09 1.57E-06 secondary metabolic process (GO:0019748) 47 4 .10 + 38.10 3.62E-06 4.28E-04 organic hydroxy compound catabolic process (GO:1901616) 59 5 .13 + 37.94 2.03E-07 2.82E-05 phenol-containing compound biosynthetic process (GO:0046189) 37 3 .08 + 36.30 7.69E-05 6.73E-03 alpha-amino acid metabolic process (GO:1901605) 211 17 .47 + 36.07 1.06E-22 6.47E-20 biogenic amine biosynthetic process (GO:0042401) 38 3 .08 + 35.34 8.33E-05 7.26E-03 monocarboxylic acid catabolic process (GO:0072329) 116 9 .26 + 34.73 3.86E-12 1.20E-09 acyl-CoA metabolic process (GO:0006637) 91 7 .20 + 34.43 1.21E-09 2.56E-07 amine biosynthetic process (GO:0009309) 39 3 .09 + 34.43 9.01E-05 7.80E-03 thioester metabolic process (GO:0035383) 91 7 .20 + 34.43 1.21E-09 2.53E-07 response to copper ion (GO:0046688) 39 3 .09 + 34.43 9.01E-05 7.76E-03 small molecule catabolic process (GO:0044282) 354 27 .79 + 34.14 2.57E-36 3.92E-32 amino acid metabolic process (GO:0006520) 291 22 .65 + 33.84 5.27E-29 6.69E-26 estrogen metabolic process (GO:0008210) 40 3 .09 + 33.57 9.73E-05 8.28E-03 acyl-CoA biosynthetic process (GO:0071616) 42 3 .09 + 31.98 1.13E-04 9.49E-03 thioester biosynthetic process (GO:0035384) 42 3 .09 + 31.98 1.13E-04 9.44E-03 dicarboxylic acid metabolic process (GO:0043648) 89 6 .20 + 30.18 4.48E-08 6.69E-06 pyridine-containing compound metabolic process (GO:0072524) 126 8 .28 + 28.42 3.37E-10 7.79E-08 primary alcohol metabolic process (GO:0034308) 96 6 .21 + 27.98 7.06E-08 1.04E-05 catecholamine metabolic process (GO:0006584) 49 3 .11 + 27.41 1.79E-04 1.45E-02 catechol-containing compound metabolic process (GO:0009712) 49 3 .11 + 27.41 1.79E-04 1.44E-02 purine nucleoside bisphosphate metabolic process (GO:0034032) 118 7 .26 + 26.56 7.54E-09 1.32E-06 ribonucleoside bisphosphate metabolic process (GO:0033875) 118 7 .26 + 26.56 7.54E-09 1.31E-06 nucleoside bisphosphate metabolic process (GO:0033865) 118 7 .26 + 26.56 7.54E-09 1.29E-06 pyridine nucleotide metabolic process (GO:0019362) 119 7 .27 + 26.33 8.00E-09 1.35E-06 nicotinamide nucleotide metabolic process (GO:0046496) 119 7 .27 + 26.33 8.00E-09 1.34E-06 purine nucleoside bisphosphate biosynthetic process (GO:0034033) 52 3 .12 + 25.83 2.14E-04 1.70E-02 ribonucleoside bisphosphate biosynthetic process (GO:0034030) 52 3 .12 + 25.83 2.14E-04 1.69E-02 nucleoside bisphosphate biosynthetic process (GO:0033866) 52 3 .12 + 25.83 2.14E-04 1.68E-02 L-amino acid metabolic process (GO:0170033) 159 9 .36 + 25.34 6.70E-11 1.60E-08 retinol metabolic process (GO:0042572) 53 3 .12 + 25.34 2.26E-04 1.74E-02 diterpenoid metabolic process (GO:0016101) 89 5 .20 + 25.15 1.60E-06 2.09E-04 proteinogenic amino acid catabolic process (GO:0170040) 54 3 .12 + 24.87 2.39E-04 1.82E-02 phenol-containing compound metabolic process (GO:0018958) 94 5 .21 + 23.81 2.10E-06 2.63E-04 lipid modification (GO:0030258) 170 9 .38 + 23.70 1.22E-10 2.86E-08 arachidonic acid metabolic process (GO:0019369) 59 3 .13 + 22.76 3.11E-04 2.31E-02 terpenoid metabolic process (GO:0006721) 100 5 .22 + 22.38 2.86E-06 3.49E-04 response to cadmium ion (GO:0046686) 61 3 .14 + 22.02 3.43E-04 2.47E-02 retinoid metabolic process (GO:0001523) 84 4 .19 + 21.32 3.69E-05 3.39E-03 reactive oxygen species metabolic process (GO:0072593) 110 5 .25 + 20.35 4.57E-06 5.32E-04 cellular lipid catabolic process (GO:0044242) 205 9 .46 + 19.65 6.45E-10 1.43E-07 monocarboxylic acid metabolic process (GO:0032787) 528 23 1.18 + 19.50 7.54E-25 4.79E-22 aromatic compound catabolic process (GO:0019439) 399 17 .89 + 19.07 5.71E-18 2.90E-15 organic cyclic compound catabolic process (GO:1901361) 427 18 .95 + 18.87 5.83E-19 3.06E-16 carboxylic acid metabolic process (GO:0019752) 801 32 1.79 + 17.88 5.90E-35 1.80E-31 xenobiotic metabolic process (GO:0006805) 126 5 .28 + 17.76 8.88E-06 9.15E-04 fatty acid derivative metabolic process (GO:1901568) 76 3 .17 + 17.67 6.54E-04 4.43E-02 purine nucleotide biosynthetic process (GO:0006164) 230 9 .51 + 17.52 1.78E-09 3.57E-07 protein acylation (GO:0043543) 77 3 .17 + 17.44 6.80E-04 4.58E-02 oxoacid metabolic process (GO:0043436) 823 32 1.84 + 17.41 1.41E-34 3.58E-31 organic acid metabolic process (GO:0006082) 830 32 1.85 + 17.26 1.85E-34 4.02E-31 purine-containing compound biosynthetic process (GO:0072522) 240 9 .54 + 16.79 2.59E-09 4.93E-07 isoprenoid metabolic process (GO:0006720) 135 5 .30 + 16.58 1.24E-05 1.25E-03 fatty acid metabolic process (GO:0006631) 327 12 .73 + 16.43 5.05E-12 1.54E-09 electron transport chain (GO:0022900) 167 6 .37 + 16.08 1.86E-06 2.38E-04 monocarboxylic acid biosynthetic process (GO:0072330) 170 6 .38 + 15.80 2.06E-06 2.60E-04 hormone metabolic process (GO:0042445) 208 7 .46 + 15.07 3.72E-07 5.10E-05 nucleotide biosynthetic process (GO:0009165) 269 9 .60 + 14.98 7.00E-09 1.26E-06 nucleoside phosphate biosynthetic process (GO:1901293) 271 9 .61 + 14.87 7.47E-09 1.32E-06 lipid catabolic process (GO:0016042) 306 10 .68 + 14.63 1.15E-09 2.47E-07 heterocycle catabolic process (GO:0046700) 379 12 .85 + 14.17 2.82E-11 7.15E-09 purine nucleotide metabolic process (GO:0006163) 466 14 1.04 + 13.45 9.42E-13 3.19E-10 sterol metabolic process (GO:0016125) 135 4 .30 + 13.26 2.33E-04 1.78E-02 cellular catabolic process (GO:0044248) 1132 33 2.53 + 13.05 8.68E-32 1.32E-28 cellular nitrogen compound catabolic process (GO:0044270) 378 11 .84 + 13.03 5.18E-10 1.18E-07 response to toxic substance (GO:0009636) 243 7 .54 + 12.90 1.06E-06 1.41E-04 carboxylic acid biosynthetic process (GO:0046394) 278 8 .62 + 12.88 1.67E-07 2.36E-05 organic acid biosynthetic process (GO:0016053) 281 8 .63 + 12.74 1.81E-07 2.53E-05 organic hydroxy compound metabolic process (GO:1901615) 494 14 1.10 + 12.69 2.07E-12 6.71E-10 purine-containing compound metabolic process (GO:0072521) 498 14 1.11 + 12.58 2.31E-12 7.33E-10 proteinogenic amino acid metabolic process (GO:0170039) 144 4 .32 + 12.43 2.98E-04 2.24E-02 olefinic compound metabolic process (GO:0120254) 147 4 .33 + 12.18 3.22E-04 2.34E-02 nucleotide metabolic process (GO:0009117) 529 14 1.18 + 11.85 5.19E-12 1.55E-09 nucleoside phosphate metabolic process (GO:0006753) 537 14 1.20 + 11.67 6.34E-12 1.86E-09 cellular response to xenobiotic stimulus (GO:0071466) 194 5 .43 + 11.54 7.06E-05 6.33E-03 cellular respiration (GO:0045333) 195 5 .44 + 11.48 7.24E-05 6.45E-03 response to nutrient (GO:0007584) 160 4 .36 + 11.19 4.44E-04 3.15E-02 aerobic respiration (GO:0009060) 164 4 .37 + 10.92 4.88E-04 3.43E-02 generation of precursor metabolites and energy (GO:0006091) 412 10 .92 + 10.87 1.98E-08 3.11E-06 alcohol metabolic process (GO:0006066) 331 8 .74 + 10.82 6.28E-07 8.47E-05 nucleobase-containing small molecule metabolic process (GO:0055086) 608 14 1.36 + 10.31 3.31E-11 8.28E-09 sulfur compound metabolic process (GO:0006790) 313 7 .70 + 10.01 5.64E-06 6.14E-04 small molecule metabolic process (GO:0044281) 1640 36 3.66 + 9.83 3.58E-31 4.96E-28 purine ribonucleotide metabolic process (GO:0009150) 384 8 .86 + 9.33 1.91E-06 2.43E-04 response to xenobiotic stimulus (GO:0009410) 434 9 .97 + 9.28 4.17E-07 5.67E-05 organic substance catabolic process (GO:1901575) 1635 33 3.65 + 9.04 1.34E-26 1.14E-23 ribonucleotide metabolic process (GO:0009259) 406 8 .91 + 8.82 2.89E-06 3.49E-04 response to metal ion (GO:0010038) 363 7 .81 + 8.63 1.48E-05 1.47E-03 steroid metabolic process (GO:0008202) 262 5 .59 + 8.54 2.87E-04 2.17E-02 ribose phosphate metabolic process (GO:0019693) 420 8 .94 + 8.53 3.71E-06 4.35E-04 energy derivation by oxidation of organic compounds (GO:0015980) 265 5 .59 + 8.45 3.03E-04 2.26E-02 organonitrogen compound catabolic process (GO:1901565) 1126 21 2.52 + 8.35 4.88E-15 1.96E-12 catabolic process (GO:0009056) 1938 35 4.33 + 8.08 4.28E-27 4.66E-24 small molecule biosynthetic process (GO:0044283) 469 8 1.05 + 7.64 8.32E-06 8.63E-04 organophosphate biosynthetic process (GO:0090407) 551 9 1.23 + 7.31 3.00E-06 3.60E-04 organophosphate metabolic process (GO:0019637) 942 15 2.10 + 7.13 9.73E-10 2.12E-07 response to inorganic substance (GO:0010035) 528 8 1.18 + 6.78 1.96E-05 1.93E-03 cellular lipid metabolic process (GO:0044255) 928 14 2.07 + 6.75 8.06E-09 1.33E-06 heterocycle biosynthetic process (GO:0018130) 1014 15 2.27 + 6.62 2.66E-09 5.01E-07 aromatic compound biosynthetic process (GO:0019438) 1024 15 2.29 + 6.56 3.04E-09 5.66E-07 regulation of hormone levels (GO:0010817) 550 8 1.23 + 6.51 2.63E-05 2.57E-03 organic cyclic compound biosynthetic process (GO:1901362) 1150 16 2.57 + 6.23 1.63E-09 3.32E-07 lipid metabolic process (GO:0006629) 1238 17 2.77 + 6.15 5.20E-10 1.17E-07 organonitrogen compound biosynthetic process (GO:1901566) 1360 17 3.04 + 5.60 2.19E-09 4.28E-07 response to nutrient levels (GO:0031667) 486 6 1.09 + 5.53 7.05E-04 4.73E-02 cellular nitrogen compound biosynthetic process (GO:0044271) 1539 18 3.44 + 5.24 1.79E-09 3.54E-07 amide metabolic process (GO:0043603) 828 9 1.85 + 4.87 7.60E-05 6.69E-03 cellular aromatic compound metabolic process (GO:0006725) 2971 29 6.64 + 4.37 5.14E-14 1.87E-11 organic cyclic compound metabolic process (GO:1901360) 3226 31 7.21 + 4.30 4.35E-15 1.79E-12 nucleobase-containing compound biosynthetic process (GO:0034654) 938 9 2.10 + 4.30 1.96E-04 1.57E-02 response to organic cyclic compound (GO:0014070) 848 8 1.89 + 4.22 5.20E-04 3.59E-02 phosphate-containing compound metabolic process (GO:0006796) 1711 15 3.82 + 3.92 2.51E-06 3.09E-04 phosphorus metabolic process (GO:0006793) 1737 15 3.88 + 3.87 3.03E-06 3.61E-04 heterocycle metabolic process (GO:0046483) 2931 24 6.55 + 3.67 1.42E-09 2.92E-07 response to oxygen-containing compound (GO:1901700) 1554 12 3.47 + 3.46 1.14E-04 9.47E-03 cellular nitrogen compound metabolic process (GO:0034641) 3288 25 7.34 + 3.40 2.42E-09 4.66E-07 organonitrogen compound metabolic process (GO:1901564) 4671 35 10.43 + 3.35 2.24E-14 8.77E-12 cellular metabolic process (GO:0044237) 6416 42 14.33 + 2.93 1.89E-17 9.27E-15 biosynthetic process (GO:0009058) 4016 25 8.97 + 2.79 1.55E-07 2.21E-05 organic substance metabolic process (GO:0071704) 7437 46 16.61 + 2.77 4.13E-21 2.42E-18 metabolic process (GO:0008152) 7979 46 17.82 + 2.58 1.06E-19 5.77E-17 cellular biosynthetic process (GO:0044249) 3866 22 8.64 + 2.55 7.13E-06 7.49E-04 primary metabolic process (GO:0044238) 6944 39 15.51 + 2.51 1.21E-12 3.99E-10 nitrogen compound metabolic process (GO:0006807) 6426 36 14.35 + 2.51 6.48E-11 1.57E-08 nucleobase-containing compound metabolic process (GO:0006139) 2743 15 6.13 + 2.45 6.21E-04 4.26E-02 organic substance biosynthetic process (GO:1901576) 3964 20 8.86 + 2.26 1.98E-04 1.58E-02 response to chemical (GO:0042221) 3780 19 8.44 + 2.25 3.37E-04 2.43E-02 cellular process (GO:0009987) 14948 44 33.39 + 1.32 9.55E-05 8.17E-03 regulation of biological process (GO:0050789) 11722 14 26.19 - .53 4.60E-04 3.24E-02 regulation of cellular process (GO:0050794) 11167 13 24.95 - .52 5.13E-04 3.55E-02 cell communication (GO:0007154) 5262 2 11.75 - .17 2.74E-04 2.08E-02 signal transduction (GO:0007165) 4789 1 10.70 - .09 1.45E-04 1.19E-02 signaling (GO:0023052) 5109 1 11.41 - .09 4.89E-05 4.44E-03