PMID- 3075131
OWN - NLM
STAT- MEDLINE
DA  - 19890802
DCOM- 19890802
LR  - 20131121
IS  - 0893-133X (Print)
IS  - 0006-3223 (Linking)
VI  - 1
IP  - 3
DP  - 1988 Sep
TI  - The current status of the dopamine hypothesis of schizophrenia.
PG  - 179-86
AB  - The dopamine hypothesis of schizophrenia is still almost entirely based on
      pharmacologic evidence. Even though a disturbed dopamine function has not yet
      been established beyond doubt in schizophrenia, recent basic research on
      dopaminergic mechanisms opens up possibilities for the development of more
      sophisticated pharmacologic tools, capable of discovering subtypes of dopamine
      receptors, which may turn out to be abnormal in schizophrenia. Such tools may
      also prove therapeutically useful. Schizophrenia is probably a heterogeneous
      group of disorders with mixed biopathology. To facilitate the search for
      nondopaminergic mechanisms of possible pathogenetic importance in subgroups of
      schizophrenia, a hypothetical model is presented that tries to explain the role
      of subcortical dopaminergic pathways for mental functions and their interaction
      with other systems. It is proposed that corticostriatothalamocortical negative
      feedback loops, also involving the mesencephalic reticular formation, are
      modulated by mesostriatal dopamine pathways to control a thalamic filter
      mechanism. The psychotomimetic actions of dopaminergic agents and phencyclidine
      may be due to interference with these feedback mechanisms.
FAU - Carlsson, A
AU  - Carlsson A
AD  - Department of Pharmacology, University of Goteborg, Sweden.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - UNITED STATES
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Receptors, Dopamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain/physiology/*physiopathology
MH  - Dopamine/*physiology
MH  - Feedback
MH  - Humans
MH  - Models, Neurological
MH  - Receptors, Dopamine/*physiology
MH  - Schizophrenia/etiology/*physiopathology
RF  - 40
EDAT- 1988/09/01
MHDA- 1988/09/01 00:01
CRDT- 1988/09/01 00:00
AID - 0893-133X(88)90012-7 [pii]
PST - ppublish
SO  - Neuropsychopharmacology. 1988 Sep;1(3):179-86.