121: Ter Arkh. 2007;79(6):25-30.

[Glomerular filtration rate is an indicator of endothelial function at early
stages of chronic kidney disease]

[Article in Russian]

Smirnov AV, Petrishchev NN, Panina IIu, Rumiantsev ASh, Degtereva OA, Tugusheva
FA, Menshutina MA.

AIM: To study effects of glomerular filtration rate (GFR) reduction on
endothelial function in patients at early stages of chronic renal kidney (CKD).
MATERIAL AND METHODS: Endothelial function of 101 patients with CKD of stage
I-III was examined using reactive hyperemia test, dopplerography of skin vessels 
with ionophoresis of acetylcholin and nitroglycerin, lipidogram parameters,
homocistein and annexin A5 levels, intima-media complex thickness of the common
carotid artery, echocardiography findings. RESULTS: Cardiovascular complications 
risk factors were found in all the patients: increased body mass index, arterial 
hypertension, dyslipoproteinemia, hyperhomocysteinemia. Reduced GFR (under 90
ml/min) is an independent factor of atherosclerosis risk. CONCLUSION: GFR
reduction corresponding to CRD of stage II is accompanied with enhancement of
apoptosis and development of vasomotor endothelial dysfunction that in
combination with risk factors contribute to development of a preclinical
atherosclerosis phase.

Publication Types: 
    English Abstract

Mesh Terms:
    Adult
    Annexins/blood
    Biological Markers/blood
    Cardiovascular Diseases/diagnosis
    Cardiovascular Diseases/etiology*
    Cardiovascular Diseases/physiopathology
    Carotid Artery, Common/physiopathology
    Carotid Artery, Common/ultrasonography
    Disease Progression
    Endothelium, Vascular/physiopathology*
    Female
    Glomerular Filtration Rate/physiology*
    Homocysteine/blood
    Humans
    Kidney Failure, Chronic/blood
    Kidney Failure, Chronic/complications
    Kidney Failure, Chronic/physiopathology*
    Male
    Middle Aged
    Prognosis
    Risk Factors
    Tunica Intima/ultrasonography
    Ultrasonography, Doppler

Substances:
    Annexins
    Biological Markers
    Homocysteine

PMID: 17684962 [PubMed - indexed for MEDLINE]

122: Klin Lab Diagn. 2007 Jun;(6):14-7.

[A procedure for determining the oxidative modification of apolipoproteins in
low-density lipoproteins]

[Article in Russian]

Ragino IuI, Polonskaia IaV, Sadovskiĭ EV.

The purpose of the present study was to develop a new procedure for estimating
the oxidative modification of apolipoproteins in low-density lipoproteins (LDLs).
The procedure was developed to use blood serum from 153 males aged 45-65 years,
including 69 patients with coronary angiography-verified coronary atherosclerosis
and 84 males from a representative sample from Novosibirsk residents of the same 
age. The new procedure is as follows: a rapid method for isolating serum LDLs,
their apolipoprotein (apoLP) protein measurement by the Lowry procedure, their
precipitation, a reaction with 2,4-dinitrophenylhydrazine in 2 M HCl solution, by
subsequently rinsing in the ethanol:ethyl acetate (1:1) solution, dissolving the 
precipitate in 8 M urea, and by determining the level of the resultant
dinitrophenylhydrazones by spectrophotometry at 363 nm, followed by conversion to
LDL concentration of apoLP. The procedure is of informative value for the degree 
of oxidative LDL modification of apoLP under oxidative stress; it is technically 
simple, takes little time, and shows a good reproducibility. The values of
determined oxidized LDL apoLP by the developed procedure highly positively
correlated with the estimates of an oxidized total blood protein fraction and
with the values of endothelial dysfunction and did not with the parameters of
blood LDL peroxidation. The detected elevated oxidation LDL apoLP in males with
coronary atherosclerosis suggests that this index is an additional marker of
potentially atherogenic LDL changes.

Publication Types: 
    English Abstract

Mesh Terms:
    Aged
    Apolipoproteins/blood*
    Biological Markers/blood
    Coronary Artery Disease/blood*
    Humans
    Lipoproteins, LDL/blood*
    Male
    Middle Aged
    Oxidation-Reduction
    Oxidative Stress*
    Protein Processing, Post-Translational*
    Reproducibility of Results
    Siberia
    Spectrophotometry, Ultraviolet

Substances:
    Apolipoproteins
    Biological Markers
    Lipoproteins, LDL

PMID: 17682473 [PubMed - indexed for MEDLINE]

123: Bioorg Khim. 2007 May-Jun;33(3):297-309.

[Oxysterols: genesis and basic functions]

[Article in Russian]

Antonchik AV, Zhabinskiĭ VN, Khripach VA.

The structural peculiarities of the most widespread oxysterols, the products of
oxidative transformations of cholesterol are discussed. The transformations
proceed with the participation of enzymatic systems of the body or as a result of
various nonenzymatic reactions. The pathways of their formation from cholesterol 
are also considered. The role of oxysterols in the maintenance of cholesterol
homeostasis and in the development of atherosclerosis is reviewed. The
possibility of using oxysterols as markers of pathological processes is
demonstrated.

Publication Types: 
    English Abstract
    Review

Mesh Terms:
    Animals
    Arteriosclerosis/metabolism
    Biological Markers/metabolism
    Biological Transport, Active
    Cholesterol/metabolism*
    Homeostasis
    Humans
    Hydroxycholesterols/chemistry
    Hydroxycholesterols/metabolism*
    Lipid Metabolism
    Liver/metabolism
    Oxidation-Reduction

Substances:
    Biological Markers
    Hydroxycholesterols
    Cholesterol

PMID: 17682385 [PubMed - indexed for MEDLINE]

124: Angiol Sosud Khir. 2007;13(1):152-5.

[Aneurysmal degeneration of the autovenous carotid-subclavian bypass: experience 
with the treatment, review of literature]

[Article in Russian]

Galkin PV, Mitroshin GE, Antonov GI, Miklashevich ER.

Tsentral'nyĭ Voennyĭ Klinicheskiĭ Gospital' im. A. A. Vishnevskogo, otdelenie
neĭrososudistoĭ khirurgii, Krasnogorsk, Rossiia.

The authors describe an experience gained with successful surgical treatment of a
73-year-old patient with a genuine aneurysm of the autoveinous carotid-subclavian
bypass, iwelve years ago the patient was operated on for stenosing
atherosclerosis of the coronary and left subclavian arteries (SCA). Aneurysm
emergence was consequent on the use of v.saphena magna as a bypass in the given
<<position>> and was not associated with appreciable circulatory disorders in the
left upper limb. However, its further existence was conjugated with the risk of
rupture and bleeding. Examination (duplex scanning, angiography) confirmed the
diagnosis of aneurysm. Besides, critical stenosis of segment I of the left SCA
and opening of the left internal carotid artery (ICA) were verified as well. The 
patient was operated on: the first stage involved angioplasty and stenting of
segment I of the left SCA; the second stage involved carotid endarterectomy on
the left, resection of bypass aneurysm together with its disengagement. On
control angiography performed 11 months later the patency of the reconstructed
arteries appeared satisfactory; stenosis was not recorded. The given case
demonstrates a modern approach to the treatment of patients with coexistent
vascular pathology (atherosclerotic stenosis plus aneurysm).

Publication Types: 
    English Abstract
    Review

Mesh Terms:
    Aged
    Arteriovenous Fistula/pathology*
    Arteriovenous Fistula/surgery*
    Carotid Arteries/surgery*
    Cerebral Revascularization/methods*
    Humans
    Male
    Subclavian Artery/surgery*

PMID: 17679988 [PubMed - indexed for MEDLINE]

125: Angiol Sosud Khir. 2007;13(1):25-30.

[Indices of antioxidant system of blood in differential diagnosis of obliterating
atherosclerosis and obliterating thromboangiitis of the lower limbs]

[Article in Russian]

Alukhanian OA, Abramov IuG, Korochanskaia SP.

Advanced Medical Training Department, Kuban State Medical Academy, Municipal
Clinical Hospital # 3, Krasnodar, Russia.

The work was aimed at elucidating the role of the indices of the antioxidant
system (AOS) of the blood and nitrogen oxide content in differential diagnosis of
atherosclerosis obiiterans (AO) and thromboangiitis obiiterans (TO) of the lower 
extremities. Presented herein are the findings of examining a total of one
hundred and thirteen 30-to-45-year-old patients (of these, 60 had TO and 53 had
AO) with various level of occlusion (from the femoropoplietal segment to the
aortoiliac zone) and the stage of chronic arterial insufficiency (CAI IIA-IV).
The control group was composed of 30 apparently healthy age-matched male
subjects. Besides the clinical, laboratory and special instrumental methods of
study, we determined the parameters of the AOS of blood and the content of
nitrogen oxide degradation products. It was determined that the directedness and 
pronouncedness of deviations in the parameters of the AOS and nitrogen oxide from
the physiological norm depended on not only the aetiology of the disease
involved, but on the degree of tissue hypoxia predetermined by the stage of CAI
of the lower limbs. For differential diagnosis between AO and TO, the most
informative should be considered the coefficient: SOD activity/catalase activity,
index of peroxide-luminol-dependent chemiluminescence and the content of nitrogen
oxide degradation products.

Publication Types: 
    English Abstract

Mesh Terms:
    Adult
    Antioxidants/metabolism*
    Arteriosclerosis Obliterans*/diagnosis
    Arteriosclerosis Obliterans*/metabolism
    Arteriosclerosis Obliterans*/physiopathology
    Biological Markers
    Catalase/metabolism
    Free Radicals/blood*
    Humans
    Male
    Middle Aged
    Nitrogen Dioxide/blood
    Thromboangiitis Obliterans*/diagnosis
    Thromboangiitis Obliterans*/metabolism
    Thromboangiitis Obliterans*/physiopathology

Substances:
    Antioxidants
    Biological Markers
    Free Radicals
    Nitrogen Dioxide
    Catalase

PMID: 17679972 [PubMed - indexed for MEDLINE]

126: Angiol Sosud Khir. 2007;13(1):17-23.

[Pathophysiological characteristics of microcirculatory disorders in chronic
arterial ischaemia of lower limbs]

[Article in Russian]

Kozlov VI, Azizov GA.

Russian University of Friendship of Peoples, Chair of Laser Medicine, Moscow,
Russia.

Presented herein are the findings of studying the peculiarities of the systemic
and regional haemodynamics in patients with obliterating atherosclerosis of the
arteries of the lower limbs. We examined a total of 186 patients with stage I-IV 
chronic arterial ischaemia of the lower extremities using the following methods: 
computer-assisted TV microscopy of the vessels of the conjunctiva of the eyeball 
and of the skin of the lower limbs, laser Doppler flowmetry (LDF) and
transcutaneous determination of oxygen tension. Revealed were: spastic,
congestive, Presented herein are the findings of studying the peculiarities of
the systemic and regional haemodynamics in patients with obliterating
atherosclerosis of the arteries of the lower limbs. We examined a total of 186
patients with stage I-IV chronic arterial ischaemia of the lower extremities
using the following methods: computer-assisted TV microscopy of the vessels of
the conjunctiva of the eyeball and of the skin of the lower limbs, laser Doppler 
flowmetry (LDF) and transcutaneous determination of oxygen tension. Revealed
were: spastic, congestive, spastic-atonic and stasic forms of microcirculatory
disorders. It was determined that microcirculatory disorders in obliterating
atherosclerosis of the lower limbs are systemic, to be revealed both in the
extremities affected and in the conjunctiva of the eyeball. A
pathophysiologically substantiated classification of microcirculatory disorders
is proposed herein.

Publication Types: 
    English Abstract

Mesh Terms:
    Adult
    Aged
    Chronic Disease
    Female
    Humans
    Ischemia/diagnosis
    Ischemia/physiopathology*
    Laser-Doppler Flowmetry
    Lower Extremity/blood supply*
    Lower Extremity/physiopathology*
    Male
    Microcirculation/physiology
    Middle Aged
    Severity of Illness Index

PMID: 17679971 [PubMed - indexed for MEDLINE]

127: Angiol Sosud Khir. 2006;12(4):127-32.

[Functional flowmetry in determining the indications for reconstructive surgical 
interventions on the major arteries of the pelvis and lower limbs]

[Article in Russian]

Kuznetsov MR, Koshkin VM, Rodionov SV, Virganskiĭ AO, Moskalenko EP, Golosnitskiĭ
PY, Dobrianskiĭ MV.

State Educational Facility of Postgraduate Medical Training Russian State Medical
University, Moscow, Russia.

The work was based on the findings of the examination and surgical management of 
69 patients with obliterating atherosclerosis of the lower limbs with various
degree of chronic arterial insufficiency. The authors analyzed the main causes
promoting development of early reocclusion of the bypasses and prostheses
following reconstructive surgical operations. They also proved the role of high
peripheral vascular resistance and, in particular, diminished functional
possibilities of the microcirculatory-bed vessels in the genesis of early
reocclusions in patients with chronic arterial insufficiency of the lower limbs. 
They also suggested a new technique of determining the carrying capacity of the
microcirculatory channel, the use of which in the preoperative period makes it
possible to predict development of early thrombotic complications, and in some
cases to wisely abstain from carrying out a reconstructive vascular intervention 
due to high risk of its poor outcomes. It is preferable for such patients to
undergo conservative pathogenetic preoperative therapy aimed at improving the
functional possibilities of the microcirculatory vessels.

Publication Types: 
    English Abstract

Mesh Terms:
    Angiography
    Arterial Occlusive Diseases/diagnosis
    Arterial Occlusive Diseases/physiopathology*
    Arterial Occlusive Diseases/surgery
    Blood Flow Velocity/physiology*
    Female
    Humans
    Leg/blood supply*
    Male
    Middle Aged
    Pelvis/blood supply*
    Preoperative Care/methods*
    Prognosis
    Severity of Illness Index
    Ultrasonography, Doppler
    Vascular Resistance/physiology*
    Vascular Surgical Procedures/methods*

PMID: 17679966 [PubMed - indexed for MEDLINE]

128: Angiol Sosud Khir. 2006;12(4):11-5.

[Endothelial function and cellular morphology and functionality inischemic limbs 
during drug therapy of obliterative atherosclerosis]

[Article in Russian]

Katelnitskiĭ II, Pleskachev SA, Katelnitskiĭ II, Matsionis AS, Povilaĭtite PE.

Rostov State Medical University, Rostov-on-Don, Russia. katelnizkji@mail.ru

The aim of the study was to develop a rationale for Vasaprostan monotherapy of
ischemia in patients with obliterative lesions in lower limb arteries. The
assessment of blood cell ultrastructure revealed deformation of erythrocytes and 
platelets, aggregation of platelets and platelets with red cells, evidencing
severe rheological alterations and increased incidence of thrombotic events in
patients with critical ischemia. Vasaprostan monotherapy was more effective then 
combined therapy without prostaglandin E1. In patients with lower limb occlusive 
arterial lesions and different ischemic grades Vasaprostan alleviated endothelial
dysfunction and normalized different morphological and functional parameters of
erythrocytes and platelets. The trend toward ultrastructural normalization was
evident in all patients after Vasaprostan administration. This trend was proved
by changes in elemental composition of erythrocytes. CONCLUSION: Vasaprostan is
beneficial for patients with obliterative lesions in lower limb arteries and can 
be used as monotherapy or preoperative management for stimulation of volumetric
blood flow and blood supply of ischemic tissues.

Publication Types: 
    English Abstract

Mesh Terms:
    Atherosclerosis/complications*
    Atherosclerosis/drug therapy
    Blood Platelets/ultrastructure
    Endothelium, Vascular/physiopathology*
    Endothelium, Vascular/ultrastructure*
    Erythrocyte Deformability/drug effects
    Erythrocytes/drug effects
    Erythrocytes/ultrastructure
    Humans
    Ischemia/etiology*
    Ischemia/pathology
    Ischemia/physiopathology
    Leg/blood supply*
    Microscopy, Electron
    Platelet Aggregation/drug effects
    Treatment Outcome
    Vasodilation/drug effects*
    Vasodilator Agents/therapeutic use*

Substances:
    Vasodilator Agents

PMID: 17679953 [PubMed - indexed for MEDLINE]

129: Zh Evol Biokhim Fiziol. 2007 Mar-Apr;43(2):155-61.

[Content of the main lipid components in blood serum lipoproteins of human and of
various animal species]

[Article in Russian]

Lizenko MV, Regerand TI, Bakhirev AM, Petrovskiĭ VI, Lizenko EI.

Using precipitation method, low-density (LDL) and high-density (HDL2 and HDL3)
lipoproteins were isolated from blood serum of human (donors, patients with
ischemic heart) diseases--IHD, with bronchial asthma--BA, with chronic
obstructive bronchitis--COB), of mammals predisposed (pig, rabbit) and resistant 
(rat, mink, Arctic fox) to atherosclerosis, of birds (hen, pigeon), of bony fish 
(trout, white-fish, pike-perch, pike, bream, burbot), and of cartilaginous fish
(sturgeon, white sturgeon). From each lipoprotein group, lipids were extracted,
separated by thin-layer chromatography, and analyzed quantitatively by the
spectrophotometric method. In phosphatidylcholine and HDL2 cholesterol esters,
bound fatty acids (FA) were determined by the method of gas-liquid
chromatography. The main amount of total cholesterol has been established to be
concentrated in human LDL, especially in the cases of IHD, and in LDL in mammals 
predisposed to atherosclerosis. In mammals resistant to atherosclerosis and in
fish the almost entire cholesterol was revealed in HDL. The phospholipid content 
in HDL was lower in patients with pathologies and in mammals predisposed to
atherosclerosis, while the highest content--in fish and mammals resistant to
atherosclerosis. In homoiothermal animals and in human the main FA amount in HDL 
was represented by the omega6-series. Acids of the omega3-series amounted to a
negligible percentage, especially in IHD. On the contrary, the HDL FA composition
of poikilothermal animals (fish) had a very high content of polyunsaturated FA of
the omega3-series. A conclusion is made that composition of lipid components in
animal lipoproteins by the example of several studied species and of human has a 
non-stable character and is submitted to changes. Their most pronounced
modifications with a negative trend took place in human LDL and HDL in IHD.

Publication Types: 
    English Abstract

Mesh Terms:
    Animals
    Asthma/metabolism
    Atherosclerosis/metabolism
    Birds
    Bronchitis, Chronic/metabolism
    Cholesterol/blood*
    Fatty Acids, Unsaturated/blood*
    Fishes
    Foxes
    Humans
    Lipoproteins, HDL/blood*
    Lipoproteins, LDL/blood*
    Mink
    Myocardial Ischemia/metabolism
    Phospholipids/blood*
    Rabbits
    Rats
    Species Specificity
    Swine

Substances:
    Fatty Acids, Unsaturated
    Lipoproteins, HDL
    Lipoproteins, LDL
    Phospholipids
    Cholesterol

PMID: 17674708 [PubMed - indexed for MEDLINE]

130: Ter Arkh. 2007;79(5):9-14.

[Cardiovascular diseases in rheumatoid arthritis]

[Article in Russian]

Popkova TV, Khelkovskaia AN, Mach ES, Aleksandrova EN, Novikov AA, Novikova DS,
Nasonov EL.

AIM: To examine the significance of conventional cardiovascular factors of risk
and immunoinflammatory markers in development of vascular atherosclerosis in
rheumatoid arthritis (RA). MATERIAL AND METHODS: Conventional cardiovascular risk
factors were evaluated in 103 RA patients (85 females and 18 males, mean age 46.3
years, duration of the disease 75 months). Forty six controls (32 females and 14 
males) had no rheumatic diseases. Vascular atherosclerosis was diagnosed at
ultrasonic scanning of the carotid arteries. Highly sensitive C-reactive protein 
(hsCRP) concentration in the blood serum was measured with highly sensitive
enzyme immunoassay. RESULTS: No differences by the rate of conventional
cardiovascular risk factors between the groups were identified except arterial
hypertension. Cardiovascular complications (ischemic heart disease, myocardial
infarction, transient ischemic attacks) occurred more frequently in RA patients. 
Intima/media complex (IMC) thickness differences between the groups were not
registered. Atherosclerotic plaques were detected more often in RA patients. In
RA patients there was a correlation between IMC thickness in the carotid arteries
and age (p = 0.00001), systolic blood pressure (p = 0.001) and diastolic blood
pressure (p = 0.01), concentration of blood cholesterol (C) (p = 0.03) and total 
coronary risk (TCR) (p = 0.003). Correlation between carotid artery IMC
thickness, duration and activity of the disease, RA systemic manifestations was
not detected (p > 0.05). A mean concentration of hsCRP in RA was higher than in
the controls: 2.8 (4.4-25.6) mg/l and 1.3 (0.6-2.7) mg/ml, respectively (p =
0.001). A positive correlation existed between concentration of hsCRP and DAS4 (p
= 0.0004) and negative--with C concentration (p = 0.01), LDL C, HDL C (p = 0.02).
Increased concentration of hsCRP, IMC thickness in the carotid arteries,
existence of atherosclerotic plaques and clinical picture of vascular
atherosclerosis related insignificantly. CONCLUSION: RA patients often suffer
from cardiovascular pathology. Immunological markers of inflammation, primarily, 
hsCRP, in addition to conventional cardiovascular risk factors are essential in
development of vascular atherosclerosis.

Publication Types: 
    English Abstract

Mesh Terms:
    Adult
    Arthritis, Rheumatoid/blood
    Arthritis, Rheumatoid/complications*
    Arthritis, Rheumatoid/drug therapy
    Arthritis, Rheumatoid/immunology
    Atherosclerosis/blood
    Atherosclerosis/etiology*
    Atherosclerosis/immunology
    Atherosclerosis/ultrasonography
    C-Reactive Protein/analysis
    Cardiovascular Diseases/blood
    Cardiovascular Diseases/etiology*
    Cardiovascular Diseases/immunology
    Cardiovascular Diseases/ultrasonography
    Carotid Arteries/ultrasonography
    Cholesterol/blood
    Female
    Humans
    Male
    Middle Aged
    Predictive Value of Tests
    Risk Factors
    Triglycerides/blood

Substances:
    Triglycerides
    Cholesterol
    C-Reactive Protein

PMID: 17672067 [PubMed - indexed for MEDLINE]

131: Arkh Patol. 2007 Mar-Apr;69(2):20-3.

[Activity of prostaglandin synthetase in human arteries in atherosclerosis
(histochemical study)]

[Article in Russian]

Cherpachenko NM, Drobkova IP, Zhdanov VS.

Synthesis of prostaglandin-synthetase at the stage of development of lipid spots 
and plaques is increased and the degree of this depends on the cell response.
Increase of PgS depends on the number of cells in the intima and adventicia. Pg
synthesis in vessels is decreasing at the stage at the fibrous plaques formation.

Publication Types: 
    English Abstract

Mesh Terms:
    Adult
    Aged
    Aorta, Thoracic/enzymology*
    Aorta, Thoracic/pathology
    Atherosclerosis/enzymology*
    Atherosclerosis/pathology
    Autopsy
    Carotid Arteries/enzymology*
    Carotid Arteries/pathology
    Coronary Vessels/enzymology*
    Coronary Vessels/pathology
    Female
    Humans
    Immunohistochemistry
    Male
    Middle Aged
    Prostaglandin-Endoperoxide Synthases/metabolism*

Substances:
    Prostaglandin-Endoperoxide Synthases

PMID: 17642186 [PubMed - indexed for MEDLINE]

132: Angiol Sosud Khir. 2006;12(3):98-103.

[Methods of medical and surgical correction of atherosclerotic aorto-arterial
pathology in management of malignant neoplasms]

[Article in Russian]

Fokin AA, Vazhenin AV, Lukin AA, Tereshin OS, Korolev VN, Mironchenko MN.

South Urals Scientific Centre, Russian Academy of Medical Sciences, Urals State
Medical Academy of Advanced Medical Training, Russian Ministry of Public Health, 
Regional Oncological Dispensary, Chelyabinsk, Russia.

The article deals with 6 -year experience of the Centre of Oncoangiosurgery of
the Chelyabinsk Regional Oncological Dispensary in treatment of patients with
concomitant malignant neoplasms and atherosclerotic lesions to the aorta and
arteries. The authors analyze therapeutic outcomes in a total of 158 patients. Of
these, 81 patients were subjected to surgical correction of the blood flow. The
presence of a clinically significant atherosclerotic lesion of the aorta and
peripheral arteries in a patient should not be interpreted as an absolute or
relative contraindication to contraindication combined treatment of the tumour
concerned. In the majority of cases, atherosclerotic occlusion of femoral and
tibial arteries was treated conservatively, using <<vasaprostan>>. In
manifestation of an atherosclerotic lesion to the carotid arteries, aorta and
iliac arteries, surgical correction of the blood flow was used more often.
Usually, vascular reconstruction was carried out first. Simultaneous
interventions were performed in 16 patients; three patients died. The technique
of operations on the aorta and arteries was traditional, while for
revascularization in peripheral lesions to the arteries of the limbs more
frequently compromising methods were used (sympathectomy, profundoplasty, local
endarterectomy) on the background of prostaglandin E1 infusions.

Publication Types: 
    Case Reports
    English Abstract

Mesh Terms:
    Adult
    Aged
    Aged, 80 and over
    Aortic Aneurysm/epidemiology*
    Aortic Aneurysm/surgery
    Aortic Aneurysm/therapy*
    Atherosclerosis/epidemiology*
    Atherosclerosis/surgery
    Atherosclerosis/therapy*
    Constriction, Pathologic/epidemiology
    Constriction, Pathologic/radiography
    Constriction, Pathologic/surgery
    Female
    Femoral Artery/radiography
    Femoral Artery/surgery
    Humans
    Male
    Middle Aged
    Neoplasms/blood supply*
    Neoplasms/epidemiology*
    Vascular Surgical Procedures/methods*

PMID: 17641621 [PubMed - indexed for MEDLINE]

133: Angiol Sosud Khir. 2006;12(3):91-7.

[Twelve-year experience of bioprosthesis implantation into infrainguinal
arteries]

[Article in Russian]

Barbarash LS, Ivanov SV, Zhuravleva IIu, Anufriev AI, Kazachek IaV, Kudriavtseva 
IuA, Zinets MG.

Research Manufacturing Task Laboratory of Reconstructive Surgery of Heart and
Vessels with Clinics, Siberian Division of Russian Academy of Medical Sciences,
Kemerovo, Russia.

The study presents the results of 315 infrainguinal artery reconstructions with
bioprostheses from bovine internal mammary artery treated with 5% solution of
diepoxide (trade name "KemAngioprosthesis"). Primary patency of
KemAngioprostheses was 37.5% (n=239) in above-knee and 7.4% (n=52) in below-knee 
femoropopliteal bypasses in 8-year period, as well as 14.9% (n=24) in
femorotibial bypass in 4.5-year period. Primary patency was significantly worse
in cases of poor outflow from legs, lower limb critical ischemia, in cases of
"end-to-side" anastomosis type, as well as in patients with concomitant ischemic 
heart disease and hypertension. KemAngioprostheses demonstrated no new or unknown
complications. The most common complication was thrombosis (45.1%); infections
occurred in 4.1%, hemorrhage - in 1% and biodegradation manifested by aneurysms
and ectasia - in 1.9% cases. Indications for KemAngioprosthesis implantations
include severe, limb-threatening ischemia with unavailable autologous vein or
simultaneous two-segment arterial reconstructions in grade III-IV acute or
chronic ischemia. Besides, KemAngioprostheses can be successfully used in
above-knee femoropopliteal reconstructions.

Publication Types: 
    Clinical Trial
    English Abstract

Mesh Terms:
    Adult
    Aged
    Arteries/surgery*
    Atherosclerosis/physiopathology*
    Atherosclerosis/surgery*
    Bioprosthesis*
    Chronic Disease
    Female
    Humans
    Ischemia/surgery
    Lower Extremity/blood supply*
    Lower Extremity/surgery*
    Male
    Middle Aged

PMID: 17641620 [PubMed - indexed for MEDLINE]

134: Angiol Sosud Khir. 2006;12(3):35-9.

[Chronic bacterial-and-viral vasculitis as a possible risk factor of disordered
stability of the coronary atherosclerosis course]

[Article in Russian]

Kvantaliani TG, Pargalava NSh, Tsiklauri PA, Abzianidze TG.

Institute of Cardiology named after Academician M D Tsinamdzgvrishvili,
Scientific Research Laboratory Test House of Physicians, Centre of Angiology and 
Vascular Surgery named after N K Bokhua, Tbilisi, Georgia.

In order to assess the real significance of some plasma and vascular indices in
disorders of the stable course of coronary heart disease (CHD) in chronic
bacterial- and viral infection-invasion, we determined the blood plasma lipid
hydrogen peroxide (LHP) activity, a direct index of the lipid peroxidation
degree, and measured the concentration of specific antibodies to Chlamydia
pneumoniae (C. pneunoniae), herpes simplex virus type 1 (HSV-1), cytomegalovirus 
(CMV) and Epstein-Barr virus (EBV) by means of the enzyme-linked immunosorbent
assay (ELISA). We examined a total of 70 patients presenting with CHD combined
with a concomitant infection both with a stable course of the disease (Group One)
and acute coronary syndrome (Group Two), as well as 50 infected people without
verified signs of coronary atherosclerosis (Group Three). The comparison group
consisted of patients with CHD, being seronegative for the causative agents
referred to above. The condition of the major vessels was appropriately assessed 
by means of duplex ultrasonography (DU). Resulting from the findings of the
carried out investigation, we singled out a triad of symptoms characteristic of
the transformation of the chronic infectious process into the recurrent phase,
which for the CHD patients with the presence of the conventional risk factors of 
atherosclerosis might become a cause of the disordered stable course of the
disease and development of acute ischaemic attacks. The revealed alterations
seemed to have been based upon an infectious-origin inflammatory lesion of the
vessels, which was duly confirmed by duplex ultrasonography.

Publication Types: 
    English Abstract

Mesh Terms:
    Adult
    Aged
    Chlamydia Infections/microbiology
    Chronic Disease
    Coronary Artery Disease/microbiology*
    Coronary Artery Disease/ultrasonography
    Coronary Artery Disease/virology
    Cytomegalovirus Infections/virology
    Echocardiography, Doppler
    Enzyme-Linked Immunosorbent Assay
    Epstein-Barr Virus Infections/virology
    Female
    Herpes Simplex/virology
    Herpesvirus 1, Human/isolation & purification
    Humans
    Lipid Peroxidation/physiology
    Male
    Middle Aged
    Risk Factors
    Vasculitis/microbiology*
    Vasculitis/ultrasonography
    Vasculitis/virology

PMID: 17641612 [PubMed - indexed for MEDLINE]

135: Angiol Sosud Khir. 2006;12(3):29-32.

[Antioxidant and metabolic therapy of lower limb chronic obliterative arterial
disease]

[Article in Russian]

Koshkin VM, Murav'ev SV, Dadova LV, Kalashov PB.

Faculty Surgery Clinics, Russian State Medical University, Moscow, Russia.

Metabolic therapy is one of several therapeutic strategies that can be used in
patients with lower limb chronic obliterative arterial disease (COAD). Tanakan
(EGb76) has demonstrated high efficiency and safety in 9 controlled clinical
trials and author's clinical series in patients with lower limb COAD. Improvement
with significant increase of pain-free walking distance and beneficial safety
profile was observed in all cases. Tanakan (EGb76) is highly effective
conventional therapeutic agent for memory and attention disorders, dizziness and 
balance disturbances in adults and elderly patients. Given a common concomitance 
of these disorders and lower limb COAD, Tanakan can be recommended as a drug of
choice for treatment of chronic obliterative arteriopathy.

Publication Types: 
    English Abstract
    Review

Mesh Terms:
    Antioxidants/therapeutic use*
    Arteriosclerosis Obliterans/drug therapy*
    Arteriosclerosis Obliterans/physiopathology*
    Atherosclerosis
    Chronic Disease
    Humans
    Lower Extremity/blood supply*
    Plant Extracts/therapeutic use
    Vasodilator Agents/therapeutic use

Substances:
    Antioxidants
    Ginkgo biloba extract 761
    Plant Extracts
    Vasodilator Agents

PMID: 17641611 [PubMed - indexed for MEDLINE]

136: Vestn Rentgenol Radiol. 2006 Jul-Aug;(4):24-8.

[Color duplex scanning in the evaluation of endovascular interventions into
autovenous shunts]

[Article in Russian]

Maliutina ED.

The paper describes a role of color duplex scanning (CDS) in the assessment of
results of endovascular interventions into autovenous shunts, including in situ
ones. From 2000 to 2005, the unit of vascular surgery of Clinical Hospital No. 83
performed 148 femoropopliteal and femototibial repairs, including the in situ
technique, in 138 patients with atherosclerosis obliterans and stenotic and
occlusive changes in the femoropopliteal segment and shin arteries. CDS
monitoring revealed 42 shunts with hemodynamically significant changes, which was
an indication for preventive endovascular operations --balloon angioplasty (BAG) 
and in one case for autovenous shunt stenting. According to CDS data, an adequate
endovascular intervention with restoration of the geometry of shunts or their
anastomoses was performed in 40 (95.2%) cases, by recording the great
bloodstream; there were hemodynamically significant complications (residual
stenoses) in 2 (4.8%) cases and hemodynamically insignificant ones in 5 (12%). In
the late period, hemodynamically significant complications (thromboses and
restenoses of an angioplasty site) and insignificant restenoses were detected in 
14 (33%) and 5 (12%) cases, respectively. After endovascular intervention,
supplemented shunt patency was 40.89 +/- 18.5% with the average follow-up length 
of 23.3 +/- 2.3 months. Based on the complications detected at a hospital stage
and in the late follow-up period after preventive primary endovascular
intervention, 10 endovascular reinterventions were performed, which increased
patency time in the group of endovascular reinterventions into the shunts by 19.6
+/- 3.8 months. Thus, the developed echosemiotics of shunts, including an in-situ
autovenous shunt permits evaluation of the state of a shunt and the hemodynamic
significance of the found changes in due time and early at surgery. CDS
monitoring makes it possible to specify indications for preventive operations, to
choose a repeated reparative procedure in a patient with thromboses of
femoropopliteal and femorotibial segments.

Publication Types: 
    English Abstract

Mesh Terms:
    Arterial Occlusive Diseases*/physiopathology
    Arterial Occlusive Diseases*/surgery
    Arterial Occlusive Diseases*/ultrasonography
    Arteriovenous Shunt, Surgical/methods
    Blood Flow Velocity/physiology
    Female
    Femoral Artery*
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Popliteal Artery*
    Reproducibility of Results
    Retrospective Studies
    Saphenous Vein/transplantation*
    Tibial Arteries*
    Treatment Outcome
    Ultrasonography, Doppler, Color*

PMID: 17639614 [PubMed - indexed for MEDLINE]

137: Ter Arkh. 2007;79(4):10-4.

[Myocardial contractility evaluation by radionuclide 4D-tomoventriculography in
patients with ischemic heart disease]

[Article in Russian]

Belenkov IuN, Sergienko VB, Bugriĭ ME.

AIM: To estimate the capabilities of the new technique radionuclide
4D-tomoventriculography (4D-RTVG) versus conventional methods, such as
radionuclide equilibrium ventriculography (REVG), ECG-synchronized single photon 
emission computerized tomography (SPECT), and echocardiography (EchoCG), in the
evaluation of systolic and diastolic dysfunction in patients with coronary heart 
disease (CHD). MATERIALS AND METHODS: The study included 29 patients (19 males
and 10 females) aged 43 to 66 years who had CHD. The diagnosis of CHD was
established on the basis of coronary angiographic findings when the signs of
coronary atherosclerosis were found. All the patients underwent 4D-RTVG, REVG,
myocardial ECG-synchronized SPECT, and Echo CG. RESULTS: There was a strong
correlation of the values obtained by 4D-RTVG versus REVG and EchoCG when
ejection fraction and left ventricular (LV) end-diastolic volume and the indices 
reflecting LV blood filling and ejection velocity were estimated. The correlation
between the values provided by 4D-RTVG and myocardial ECG-synchronized SPECT
females was slightly weaker. CONCLUSION: The findings suggest that 4D-RTVG is
highly reliable in evaluating both LV systolic and diastolic functions. That fact
the technique is easy-to-use and mini-invasive shows that it may be clinically
applied.

Publication Types: 
    Comparative Study
    English Abstract

Mesh Terms:
    Adult
    Aged
    Diastole
    Echocardiography
    Electrocardiography
    Female
    Heart/physiopathology
    Heart/radionuclide imaging*
    Humans
    Male
    Middle Aged
    Myocardial Contraction/physiology*
    Myocardial Ischemia/physiopathology
    Myocardial Ischemia/radionuclide imaging*
    Radionuclide Ventriculography
    Sensitivity and Specificity
    Systole
    Technetium Tc 99m Sestamibi/diagnostic use
    Tomography, Emission-Computed, Single-Photon
    Ventricular Function, Left/physiology

Substances:
    Technetium Tc 99m Sestamibi

PMID: 17564011 [PubMed - indexed for MEDLINE]

138: Zh Vopr Neirokhir Im N N Burdenko. 2007 Jan-Mar;(1):36-9; discussion 39.

[Venous thromboembolic events in neurosurgical patients. Part I. Analysis of
their incidence on the basis of autopsy material]

[Article in Russian]

Markina MS, Lubnin AIu, Korshunov AG, Kozlov AV.

Mesh Terms:
    Adult
    Age Factors
    Atherosclerosis/complications
    Atherosclerosis/epidemiology
    Autopsy
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Moscow/epidemiology
    Neurosurgical Procedures/adverse effects
    Neurosurgical Procedures/mortality
    Neurosurgical Procedures/statistics & numerical data*
    Postoperative Complications/epidemiology
    Postoperative Complications/etiology
    Postoperative Complications/mortality
    Pulmonary Artery/pathology
    Thromboembolism/epidemiology*
    Thromboembolism/etiology
    Thromboembolism/mortality
    Venous Thrombosis/diagnosis
    Venous Thrombosis/epidemiology*
    Venous Thrombosis/mortality

PMID: 17526251 [PubMed - indexed for MEDLINE]

139: Patol Fiziol Eksp Ter. 2007 Jan-Mar;(1):18-21.

[Role of lysosomal enzymes in the genesis of major clinical and
pathophysiological syndromes: facts and hypotheses]

[Article in Russian]

Efremov AV, Ruiatkina LA, Tsygankova OV, Bondareva ZG.

Publication Types: 
    Review

Mesh Terms:
    Animals
    Apoptosis
    Atherosclerosis/enzymology
    Atherosclerosis/etiology
    Cardiovascular Diseases/enzymology*
    Cardiovascular Diseases/etiology
    Enzymes/physiology*
    Humans
    Lysosomes/enzymology*
    Lysosomes/pathology

Substances:
    Enzymes

PMID: 17526212 [PubMed - indexed for MEDLINE]

140: Ter Arkh. 2007;79(3):84-92.

[Systemic vasculitis and atherosclerosis]

[Article in Russian]

Shilkina NP, Driazhenkova IV.

Publication Types: 
    Review

Mesh Terms:
    Atherosclerosis*/diagnosis
    Atherosclerosis*/etiology
    Atherosclerosis*/immunology
    Diagnosis, Differential
    Humans
    Vasculitis*/diagnosis
    Vasculitis*/etiology
    Vasculitis*/immunology

PMID: 17526204 [PubMed - indexed for MEDLINE]