Analysis Type: PANTHER Overrepresentation Test (Released 20240807) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.15066566 Released 2025-03-16 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO biological process complete Homo sapiens - REFLIST (20580) upload_1 (21) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) amino acid catabolic process (GO:0009063) 109 13 .11 + > 100 2.42E-25 5.97E-22 organic acid metabolic process (GO:0006082) 796 19 .81 + 23.39 2.30E-25 6.82E-22 oxoacid metabolic process (GO:0043436) 788 19 .80 + 23.63 1.90E-25 7.02E-22 carboxylic acid catabolic process (GO:0046395) 228 15 .23 + 64.47 1.49E-25 7.38E-22 organic acid catabolic process (GO:0016054) 228 15 .23 + 64.47 1.49E-25 1.11E-21 carboxylic acid metabolic process (GO:0019752) 766 19 .78 + 24.31 1.10E-25 1.63E-21 alpha-amino acid metabolic process (GO:1901605) 189 14 .19 + 72.59 2.05E-24 3.79E-21 amino acid metabolic process (GO:0006520) 270 15 .28 + 54.44 2.01E-24 4.25E-21 alpha-amino acid catabolic process (GO:1901606) 96 12 .10 + > 100 1.48E-23 2.43E-20 proteinogenic amino acid metabolic process (GO:0170039) 155 13 .16 + 82.19 2.90E-23 4.30E-20 small molecule catabolic process (GO:0044282) 354 15 .36 + 41.53 1.26E-22 1.69E-19 proteinogenic amino acid catabolic process (GO:0170040) 75 11 .08 + > 100 2.40E-22 2.96E-19 small molecule metabolic process (GO:0044281) 1576 19 1.61 + 11.81 1.03E-19 1.17E-16 dicarboxylic acid metabolic process (GO:0043648) 97 10 .10 + > 100 1.13E-18 1.20E-15 glycine metabolic process (GO:0006544) 13 6 .01 + > 100 8.79E-16 8.68E-13 L-amino acid catabolic process (GO:0170035) 75 8 .08 + > 100 4.15E-15 3.84E-12 non-proteinogenic amino acid catabolic process (GO:0170044) 18 6 .02 + > 100 9.48E-15 8.26E-12 L-amino acid metabolic process (GO:0170033) 154 9 .16 + 57.27 1.58E-14 1.30E-11 non-proteinogenic amino acid metabolic process (GO:0170041) 60 7 .06 + > 100 1.40E-13 1.09E-10 serine family amino acid metabolic process (GO:0009069) 31 6 .03 + > 100 3.73E-13 2.76E-10 catabolic process (GO:0009056) 2040 16 2.08 + 7.69 1.03E-12 7.28E-10 2-oxoglutarate metabolic process (GO:0006103) 18 5 .02 + > 100 5.62E-12 3.79E-09 glyoxylate metabolic process (GO:0046487) 8 4 .01 + > 100 5.59E-11 3.60E-08 serine family amino acid catabolic process (GO:0009071) 12 4 .01 + > 100 3.94E-10 2.43E-07 glyoxylate catabolic process (GO:0009436) 3 3 .00 + > 100 9.16E-10 5.02E-07 glycine catabolic process (GO:0006546) 3 3 .00 + > 100 9.16E-10 5.22E-07 glycine decarboxylation via glycine cleavage system (GO:0019464) 3 3 .00 + > 100 9.16E-10 5.43E-07 proline catabolic process (GO:0006562) 4 3 .00 + > 100 3.66E-09 1.87E-06 4-hydroxyproline catabolic process (GO:0019470) 4 3 .00 + > 100 3.66E-09 1.94E-06 alanine metabolic process (GO:0006522) 5 3 .01 + > 100 9.14E-09 4.11E-06 glutamine family amino acid catabolic process (GO:0009065) 24 4 .02 + > 100 8.40E-09 4.15E-06 alanine catabolic process (GO:0006524) 5 3 .01 + > 100 9.14E-09 4.23E-06 glycine biosynthetic process (GO:0006545) 5 3 .01 + > 100 9.14E-09 4.37E-06 4-hydroxyproline metabolic process (GO:0019471) 6 3 .01 + > 100 1.83E-08 7.96E-06 monocarboxylic acid metabolic process (GO:0032787) 509 8 .52 + 15.40 2.03E-08 8.60E-06 metabolic process (GO:0008152) 7642 20 7.80 + 2.56 3.32E-08 1.37E-05 modified amino acid catabolic process (GO:0042219) 34 4 .03 + > 100 3.64E-08 1.46E-05 aspartate family amino acid metabolic process (GO:0009066) 38 4 .04 + > 100 5.78E-08 2.25E-05 monocarboxylic acid catabolic process (GO:0072329) 111 5 .11 + 44.14 7.92E-08 3.01E-05 proteinogenic amino acid biosynthetic process (GO:0170038) 42 4 .04 + 93.33 8.74E-08 3.24E-05 proline metabolic process (GO:0006560) 10 3 .01 + > 100 1.09E-07 3.95E-05 aspartate family amino acid catabolic process (GO:0009068) 11 3 .01 + > 100 1.50E-07 5.30E-05 alpha-amino acid biosynthetic process (GO:1901607) 50 4 .05 + 78.40 1.79E-07 6.17E-05 pyruvate family amino acid metabolic process (GO:0009078) 13 3 .01 + > 100 2.60E-07 8.76E-05 aldehyde catabolic process (GO:0046185) 14 3 .01 + > 100 3.31E-07 1.09E-04 serine family amino acid biosynthetic process (GO:0009070) 15 3 .02 + > 100 4.13E-07 1.33E-04 amino acid biosynthetic process (GO:0008652) 63 4 .06 + 62.22 4.59E-07 1.45E-04 glutamine family amino acid metabolic process (GO:0009064) 64 4 .07 + 61.25 4.89E-07 1.51E-04 aldehyde metabolic process (GO:0006081) 68 4 .07 + 57.65 6.25E-07 1.89E-04 modified amino acid metabolic process (GO:0006575) 179 5 .18 + 27.37 8.56E-07 2.54E-04 glycine biosynthetic process, by transamination of glyoxylate (GO:0019265) 2 2 .00 + > 100 9.92E-07 2.83E-04 D-amino acid catabolic process (GO:0019478) 2 2 .00 + > 100 9.92E-07 2.88E-04 aspartate catabolic process (GO:0006533) 3 2 .00 + > 100 2.97E-06 8.16E-04 proline catabolic process to glutamate (GO:0010133) 3 2 .00 + > 100 2.97E-06 8.31E-04 glutamate metabolic process (GO:0006536) 31 3 .03 + 94.84 4.04E-06 1.09E-03 tricarboxylic acid cycle (GO:0006099) 33 3 .03 + 89.09 4.90E-06 1.30E-03 D-amino acid metabolic process (GO:0046416) 4 2 .00 + > 100 5.94E-06 1.49E-03 L-alanine metabolic process (GO:0042851) 4 2 .00 + > 100 5.94E-06 1.52E-03 carboxylic acid biosynthetic process (GO:0046394) 268 5 .27 + 18.28 6.19E-06 1.53E-03 L-alanine catabolic process (GO:0042853) 4 2 .00 + > 100 5.94E-06 1.54E-03 energy derivation by oxidation of organic compounds (GO:0015980) 270 5 .28 + 18.15 6.42E-06 1.56E-03 organic acid biosynthetic process (GO:0016053) 271 5 .28 + 18.08 6.53E-06 1.56E-03 primary metabolic process (GO:0044238) 6778 17 6.92 + 2.46 8.45E-06 1.99E-03 sulfur compound metabolic process (GO:0006790) 314 5 .32 + 15.61 1.33E-05 3.09E-03 aerobic respiration (GO:0009060) 161 4 .16 + 24.35 1.95E-05 4.44E-03 generation of precursor metabolites and energy (GO:0006091) 371 5 .38 + 13.21 2.97E-05 6.67E-03 aspartate metabolic process (GO:0006531) 9 2 .01 + > 100 3.55E-05 7.86E-03 cellular respiration (GO:0045333) 189 4 .19 + 20.74 3.65E-05 7.95E-03 succinyl-CoA metabolic process (GO:0006104) 10 2 .01 + > 100 4.44E-05 9.54E-03 pyruvate metabolic process (GO:0006090) 72 3 .07 + 40.83 5.22E-05 1.10E-02 pyruvate family amino acid catabolic process (GO:0009080) 11 2 .01 + > 100 5.42E-05 1.13E-02 small molecule biosynthetic process (GO:0044283) 466 5 .48 + 10.52 8.78E-05 1.81E-02 thioester metabolic process (GO:0035383) 92 3 .09 + 31.96 1.08E-04 2.17E-02 acyl-CoA metabolic process (GO:0006637) 92 3 .09 + 31.96 1.08E-04 2.20E-02 purine-containing compound metabolic process (GO:0072521) 506 5 .52 + 9.68 1.29E-04 2.56E-02 dicarboxylic acid catabolic process (GO:0043649) 17 2 .02 + > 100 1.34E-04 2.61E-02