ACTL7A_N PF16840 Domain 14 101 63.4 65 14.41 Changed Actin-like protein 7A N-terminus Adhes-Ig_like PF09085 Domain 10 169 108.6 60 28.8 Changed Adhesion molecule, immunoglobulin-like Albumin_I PF08027 Domain 2 48 34.8 61 27.66 Changed Albumin I chain b Albumin_I_a PF16720 Domain 1 98 47.5 59 37.35 Changed Albumin I chain a Arc_C PF18162 Domain 1 157 82.9 86 20.89 Changed Arc C-lobe Arc_MA PF19284 Domain 4 161 107.6 83 26.42 Changed Arc MA domain AUDH_Cupin PF18637 Domain 16 93 145.5 41 21.94 Changed Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain Bac_GH3_C PF18034 Domain 11 105 137.8 41 26.05 Changed Bacterial Glycosyl hydrolase family 3 C-terminal domain Bac_RepA_C PF18008 Domain 7 65 88 44 29.96 Changed Replication initiator protein A C-terminal domain BaffR-Tall_bind PF09256 Domain 9 133 29.7 55 14.97 Changed BAFF-R, TALL-1 binding BCMA-Tall_bind PF09257 Domain 7 174 36.7 62 18.01 Changed BCMA, TALL-1 binding bCoV_NAB PF16251 Domain 2 46 116.3 46 2.02 Changed Betacoronavirus nucleic acid-binding (NAB) BOFC_N PF08977 Domain 15 188 50.8 42 29.62 Changed Bypass of Forespore C, N terminal CAP18_C PF12153 Domain 9 75 27.4 48 15.43 Changed LPS binding domain of CAP18 (C terminal) CBD_PlyG PF12123 Domain 7 42 45 43 17.13 Changed PlyG Cell wall binding domain CBM77 PF18283 Domain 13 96 108.1 42 11.82 Changed Carbohydrate binding module 77 CBM_5_12_2 PF14600 Domain 10 195 59 47 7.11 Changed Cellulose-binding domain CD4-extracel PF09191 Domain 20 171 108.2 50 24.14 Changed CD4, extracellular CENP-B_dimeris PF09026 Domain 1 117 92.5 63 18.64 Changed Centromere protein B dimerisation domain CholecysA-Rec_N PF09193 Domain 3 171 48 65 11.32 Changed Cholecystokinin A receptor, N-terminal CLIP_SPH_Scar PF18399 Domain 20 131 65.1 54 6.02 Changed Clip-domain serine protease homolog Scarface ColG_sub PF18496 Domain 13 54 115.8 44 11.44 Changed Collagenase G catalytic helper subdomain Colipase PF01114 Domain 7 187 39 65 35.04 Changed Colipase, N-terminal domain CoV_NSP15_N PF19219 Domain 19 78 61 57 0.96 Changed Coronavirus replicase NSP15, N-terminal oligomerisation CoV_NSP4_C PF16348 Domain 5 115 95.9 48 1.66 Changed Coronavirus replicase NSP4, C-terminal CoV_NSP7 PF08716 Domain 5 109 83.9 51 1.46 Changed Coronavirus replicase NSP7 CoV_NSP9 PF08710 Domain 5 115 110.3 48 1.91 Changed Coronavirus replicase NSP9 Crystall_4 PF17945 Domain 10 52 89 54 29.86 Changed Beta/Gamma crystallin Csd3_N PF18059 Domain 8 77 83.6 42 20.58 Changed Csd3 N-terminal CxC7 PF18866 Domain 3 45 61.7 51 18.77 Changed CxC7 like cysteine cluster associated with KDZ transposases DarA_C PF18789 Domain 28 136 67.1 42 22.78 Changed Defence against restriction A C-terminal Defensin_1 PF00323 Domain 36 196 28.9 44 30.81 Changed Mammalian defensin DNA_ligase_C PF17879 Domain 1 161 71.4 49 27.67 Changed DNA ligase C-terminal domain Doppel PF11466 Domain 7 86 30 73 16.53 Changed Prion-like protein Doppel DpnI_C PF17726 Domain 13 105 69.1 41 22.46 Changed Dam-replacing HTH domain DR2241 PF18069 Domain 25 144 108.3 41 28.43 Changed DR2241 stabilising domain DSX_dimer PF08828 Domain 10 109 47.3 53 15.52 Changed Doublesex dimerisation domain DUF1882 PF08966 Domain 9 58 72.8 49 40.53 Changed Domain of unknown function (DUF1882) DUF1964 PF09244 Domain 4 41 67.6 46 13.64 Changed Domain of unknown function (DUF1964) DUF1968 PF09291 Domain 13 127 79.3 42 43.37 Changed Domain of unknown function (DUF1968) DUF1970 PF09301 Domain 2 53 108.2 42 23.15 Changed Domain of unknown function (DUF1970) DUF3848 PF12959 Domain 11 178 94 43 42.25 Changed Protein of unknown function (DUF3848) DUF3944 PF13099 Domain 9 74 34.6 44 14.8 Changed Domain of unknown function (DUF3944) DUF4973 PF16343 Domain 9 71 130.9 47 39.28 Changed Domain of unknown function (DUF4973) DUF5624 PF18538 Domain 21 52 131.1 41 26.04 Changed Domain of unknown function (DUF5624) DUF5628 PF18621 Domain 10 64 109.8 57 32.27 Changed Family of unknown function (DUF5628) DUF5631 PF18645 Domain 16 69 94.5 49 23.61 Changed Family of unknown function (DUF5631) DUF5632 PF18646 Domain 10 71 79.2 54 19.4 Changed Family of unknown function (DUF5632) DUF6321 PF19846 Domain 19 98 70.4 55 22.11 Changed Domain of unknown function (DUF6321) DUF6436 PF20029 Domain 67 176 58.9 42 31.97 Changed Domain of unknown function (DUF6436) DUF6743 PF20528 Domain 8 62 69.8 74 28.4 New Domain of unknown function (DUF6743) DUF6752 PF20537 Domain 46 93 52.4 44 40.71 New Domain of unknown function (DUF6752) EAGR_box PF16713 Domain 22 43 34 43 9.34 Changed Enriched in aromatic and glycine Residues box EKAL PF17986 Domain 2 42 52.6 56 7.11 Changed EMP3-KAHRP-like N-terminal domain EKLF_TAD2 PF16833 Domain 11 97 27 68 7.45 Changed Erythroid krueppel-like transcription factor, transactivation 2 EpCAM_N PF18635 Domain 11 127 32.6 72 10.44 Changed Epithelial cell adhesion molecule N-terminal domain Epiglycanin_C PF14654 Domain 4 113 79.1 53 13.57 Changed Mucin, catalytic, TM and cytoplasmic tail region Ezh2_MCSS PF18600 Domain 21 151 52.3 51 4.62 Changed MCSS domain EZH2_N PF18601 Domain 18 151 78.5 56 6.84 Changed EZH2 N-terminal domain Fer4_2 PF12797 Domain 190 76 22.1 41 8.95 Changed 4Fe-4S binding domain Fer4_23 PF18009 Domain 6 142 82.7 51 21.62 Changed 4Fe-4S iron-sulfur cluster binding domain Fibrinogen_aC PF12160 Domain 10 156 67.4 47 8.38 Changed Fibrinogen alpha C domain GAGA PF09237 Domain 2 186 46.1 42 9.8 Changed GAGA factor Gag_p17 PF00540 Domain 3 68 132.1 55 14.79 Changed gag gene protein p17 (matrix protein) GAIN_A PF18619 Domain 12 160 47.7 73 6.85 Changed GPCR-Autoproteolysis-INducing (GAIN) subdomain A Gal11_ABD1 PF18535 Domain 7 49 84 42 8.4 Changed Gal11 activator-binding domain (ABD1) H-K_ATPase_N PF09040 Domain 2 145 40.7 83 3.93 Changed Gastric H+/K+-ATPase, N terminal domain Head_binding PF09008 Domain 4 71 108.5 51 17.86 Changed Head binding HetR_C PF18460 Domain 8 91 79.1 63 26.25 Changed Heterocyst differentiation regulator C-terminal Hood domain HJURP_mid PF12346 Domain 13 141 114.2 63 16.54 Changed Holliday junction recognition protein-associated repeat HMw1_D2 PF18254 Domain 5 70 87.7 49 14.22 Changed HMW1 domain 2 HP1451_C PF18472 Domain 29 77 66.8 51 23.05 Changed HP1451 C-terminal domain HscB_4_cys PF18256 Domain 9 199 26.8 72 12.8 Changed Co-chaperone HscB tetracysteine metal binding motif HTH_49 PF18010 Domain 1 67 29.1 64 16.07 Changed Cry35Ab1 HTH C-terminal domain HTH_54 PF18607 Domain 9 55 90.9 52 23 Changed ParA helix turn helix domain HTH_55 PF18622 Domain 3 58 103.7 80 16.79 Changed RctB helix turn helix domain Ig_C19orf38 PF17737 Domain 7 179 88.9 48 32.88 Changed Ig domain in C19orf38 (HIDE1) Il13Ra_Ig PF18001 Domain 8 159 94.2 60 21.92 Changed Interleukin-13 receptor subunit alpha Ig-like domain IMP2_C PF18591 Domain 6 43 62.8 42 32.96 Changed Immune Mapped Protein 2 (IMP2) C-terminal domain Involucrin_N PF10583 Domain 9 81 68.2 68 17.31 Changed Involucrin of squamous epithelia N-terminus KfrB PF18790 Domain 19 44 60.4 42 44.74 Changed KfrB protein Kisspeptin PF15152 Domain 8 104 73.2 57 42.47 Changed Kisspeptin KorB_C PF06613 Domain 6 57 58.3 45 16.41 Changed KorB C-terminal beta-barrel domain LIFR_N PF18207 Domain 33 198 78.1 43 7.42 Changed Leukemia inhibitory factor receptor N-terminal domain LPD11 PF18824 Domain 23 63 68.1 47 8.02 Changed Large polyvalent protein-associated domain 11 LPD15 PF18828 Domain 19 56 97.6 52 10.61 Changed Large polyvalent-protein-associated domain 15 LPD26 PF18842 Domain 13 56 60.2 48 7.5 Changed Large polyvalent protein associated domain 26 LPD5 PF18799 Domain 14 50 145.9 43 5.58 Changed Large polyvalent protein-associated domain 5 MapZ_C2 PF18708 Domain 21 93 86 50 15.34 Changed MapZ extracellular C-terminal domain 2 MCR PF18509 Domain 26 100 28.5 44 11.96 Changed Magnetochrome domain MCR_alpha PF02249 Domain 13 85 128.8 61 22.94 Changed Methyl-coenzyme M reductase alpha subunit, C-terminal domain MotA_activ PF09114 Domain 1 45 95.3 60 44.76 Changed Transcription factor MotA, activation domain Myelin-PO_C PF10570 Domain 3 150 62.5 82 24.81 Changed Myelin-PO cytoplasmic C-term p65 binding region NES_C_h PF18208 Domain 7 59 107.6 50 16.74 Changed Nicking enzyme C-terminal middle helical domain NmU-R2_C_term PF19285 Domain 29 178 66.2 54 16.71 Changed Neuromedin-U receptor 2, C-terminal Ole_e_6 PF09253 Domain 8 126 38.1 44 41.13 Changed Pollen allergen Ole e 6 partial_CstF PF15861 Domain 8 61 61.1 47 7.81 Changed Partial cleavage stimulation factor domain PBCV_basic_adap PF08789 Domain 9 120 34.9 42 18.79 Changed PBCV-specific basic adaptor domain PCSK9_C2 PF18464 Domain 15 158 63.9 44 9.56 Changed Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain Peripla_BP_7 PF18610 Domain 5 93 71 77 16.64 Changed Periplasmic binding protein domain Phage_int_SAM_6 PF18644 Domain 15 60 131.9 49 37.34 Changed Phage integrase SAM-like domain Phage_tube_C PF20608 Domain 9 59 80.2 57 18.12 New Phage tail tube protein C-terminal domain PNPase_C PF12111 Domain 15 167 36.6 47 3.61 Changed Polyribonucleotide phosphorylase C terminal PnpCD_PnpD_N PF18191 Domain 1 65 149.3 64 44.65 Changed Hydroquinone 1,2-dioxygenase large subunit N-terminal Pox_polyA_pol PF03296 Domain 7 45 149.8 57 30.7 Changed Poxvirus poly(A) polymerase nucleotidyltransferase domain PUB_1 PF18486 Domain 4 183 64.5 83 6.17 Changed PNGase/UBA- or UBX-containing domain Qn_am_d_aIV PF09100 Domain 12 133 132.9 45 24.56 Changed Quinohemoprotein amine dehydrogenase, alpha subunit domain IV RcsD_ABL PF16359 Domain 11 112 103.1 48 12.18 Changed RcsD-ABL domain RDM PF11002 Domain 16 153 41.9 63 13.99 Changed RFPL defining motif (RDM) RecO_N_2 PF13114 Domain 11 75 71.4 47 34.21 Changed RecO N terminal RelB_leu_zip PF16180 Domain 5 118 77.4 74 14.51 Changed RelB leucine zipper Rieske_3 PF18465 Domain 19 155 93.9 48 11.37 Changed Rieske 3Fe-4S RKP_N PF19322 Domain 30 184 134.2 52 11.23 Changed E3 ubiquitin-protein ligase RKP N-terminus RVT_connect PF06815 Domain 2 44 101.7 63 7.94 Changed Reverse transcriptase connection domain SAM_DrpA PF18255 Domain 8 44 62.1 48 22.41 Changed DNA processing protein A sterile alpha motif domain SepRS_C PF18006 Domain 23 58 33.7 44 6.32 Changed O-phosphoseryl-tRNA synthetase C-terminal domain SNN_cytoplasm PF09051 Domain 2 190 26.2 87 28.92 Changed Stannin cytoplasmic SNN_transmemb PF09049 Domain 2 194 31.9 96 35.27 Changed Stannin transmembrane SpuA_C PF18033 Domain 7 139 92 42 6.07 Changed SpuA C-terminal SSSPR-51 PF18877 Domain 11 103 48.6 44 10.11 Changed SSSPR-51 domain STAT2_C PF12188 Domain 7 141 55.5 75 6.63 Changed Signal transducer and activator of transcription 2 C terminal Sugarporin_N PF11471 Domain 10 105 30.9 46 6.25 Changed Maltoporin periplasmic N-terminal extension T4_Gp59_N PF08993 Domain 2 146 91.9 42 44.19 Changed T4 gene Gp59 loader of gp41 DNA helicase Tcell_CD4_C PF12104 Domain 1 165 27 66 6.16 Changed T cell CD4 receptor C terminal region Thiol_cytolys_C PF17440 Domain 9 74 100.5 50 21.45 Changed Thiol-activated cytolysin beta sandwich domain Top6b_C PF18000 Domain 16 146 110 43 14.06 Changed Type 2 DNA topoisomerase 6 subunit B C-terminal domain T_Ag_DNA_bind PF02217 Domain 11 94 94.3 44 13.85 Changed Origin of replication binding protein Urease_linker PF18473 Domain 13 178 33 44 4.22 Changed Urease subunit beta-alpha linker domain Vexin PF15505 Domain 7 168 74 59 40.72 Changed Vexin domain VirDNA-topo-I_N PF09266 Domain 10 45 57.4 51 18.03 Changed Viral DNA topoisomerase I, N-terminal VitD-bind_III PF09164 Domain 11 195 64.1 59 13.59 Changed Vitamin D binding protein, domain III Vitelline_membr PF10542 Domain 7 104 36.3 70 25.27 Changed Vitelline membrane cysteine-rich region YMF19_C PF06449 Domain 2 134 48.5 79 28.15 Changed ATP synthase YMF19, C-terminal zf-C2H2_10 PF16588 Domain 22 92 22.2 52 11.89 Changed C2H2 zinc-finger zf-CCCH_8 PF18633 Domain 5 127 27.9 77 2.95 Changed Zinc-finger antiviral protein (ZAP) zinc finger domain 3 zf-CCHC_5 PF14787 Domain 5 186 34 44 5.95 Changed GAG-polyprotein viral zinc-finger zf-RAG1 PF10426 Domain 6 164 30 67 2.9 Changed Recombination-activating protein 1 zinc-finger domain zf-WRNIP1_ubi PF18279 Domain 1 101 21 90 3.34 Changed Werner helicase-interacting protein 1 ubiquitin-binding domain ZoocinA_TRD PF16775 Domain 4 181 79.3 51 37 Changed Target recognition domain of lytic exoenzyme