RID: G11956NY016	
Job Title:RNA-directed RNA polymerase nsp12				
Program: BLASTP 
Query: RNA-directed RNA polymerase nsp12 ID: lcl|Query_76910(amino acid) Length: 934
Database: swissprot Non-redundant UniProtKB/SwissProt sequences
	
Sequences producing significant alignments:
                                                                  Scientific      Common                     Max    Total Query   E   Per.   Acc.                        
Description                                                       Name            Name            Taxid      Score  Score cover Value Ident  Len        Accession        
RecName: Full=Replicase polyprotein 1ab; Short=pp1ab; AltName:... Berne virus     NA              11156      122    122   56%   1e-26 24.26  6857       P0C6V7.1         

Alignments:

>RecName: Full=Replicase polyprotein 1ab; Short=pp1ab; AltName: Full=ORF1ab polyprotein; Contains: RecName: Full=Non-structural protein 1; Short=nsp1; Contains: RecName: Full=Non-structural protein 2; Short=nsp2; Contains: RecName: Full=3C-like serine proteinase; Short=3CLSP; AltName: Full=M-PRO; AltName: Full=nsp3; AltName: Full=p27; Contains: RecName: Full=Non-structural protein 4; Short=nsp4; Contains: RecName: Full=Non-structural protein 5; Short=nsp5; Contains: RecName: Full=Non-structural protein 6; Short=nsp6; Contains: RecName: Full=Non-structural protein 7; Short=nsp7; Contains: RecName: Full=Non-structural protein 8; Short=nsp8; Contains: RecName: Full=RNA-directed RNA polymerase; Short=Pol; Short=RdRp; AltName: Full=nsp10; AltName: Full=p100; Contains: RecName: Full=Helicase; Short=Hel; AltName: Full=nsp11; AltName: Full=p67; Contains: RecName: Full=Exoribonuclease; Short=ExoN; AltName: Full=nsp12; Contains: RecName: Full=Non-structural protein 13; Short=nsp13; Contains: RecName: Full=Uridylate-specific endoribonuclease; AltName: Full=NendoU; AltName: Full=nsp14; Contains: RecName: Full=Putative 2'-O-methyl transferase; AltName: Full=nsp15 [Berne virus]
Sequence ID: P0C6V7.1 Length: 6857
Range 1: 4883 to 5383

Score:122 bits(305), Expect:1e-26, 
Method:Compositional matrix adjust., 
Identities:131/540(24%), Positives:219/540(40%), Gaps:47/540(8%)

Query  395   TPCFSVAALTTGLTFQTVRPGNFNKDFYDFVVSKGFFKEGSSV--TLRHFFFAQDGHAAI  452
             TP  SV          +         FYD  + +     G       ++F++  +   A+
Sbjct  4883  TPAISVGEGVYAANVPSASATKQKIPFYDVGLCQELTDAGVDCGEAFKYFYYLSNPAGAL  4942

Query  453   TDYSYYAYNLPTMCDIKQMLFCMEVVDRYFEIYDGGCLNASEVIVNNLDKSAGHPFNKFG  512
              D  YY Y        K +    + + R  E Y    +N          + +    N  G
Sbjct  4943  ADVCYYDYQGTGFYSPKLLAGVYDFMKRVTECYR---INERFTYEQAKPRKSSMGINITG  4999

Query  513   -KARVYYESLSYQEQDELFAMTKRNVLPTITQMNLKYAISAKNRARTVAGVSILSTMTNR  571
              +    Y +L  +    LF   ++  LP  T++  K+A+SAK RARTV+  S +++   R
Sbjct  5000  YQQDAVYRALGPENIARLFEYAQKAPLPFCTKIITKFALSAKARARTVSSCSFIASTIFR  5059

Query  572   QYHQKMLKSM---AATRGSTCVIGTTKFYGGWDFMLKTLYKDVDNPHLMGWDYPKCDRAM  628
               H+ +   M   A   G  C+IG +K+   +   LK  Y  ++   + G DY KCDR  
Sbjct  5060  FAHKPVTSKMVEVAQNSGGFCLIGVSKYGLKFSKFLKDKYGAIEGFDVFGSDYTKCDRTF  5119

Query  629   PNMCRIFASLILARKHSTCCTNTDRFYRLANECAQVLSEYVLCGGGYYVKPGGTSSGDAT  688
             P   R   + +L           ++ +   NE    + + +LC G    KPGGTSSGDAT
Sbjct  5120  PLSFRALTAALLYELGEW----DEKSWLYLNEVNSYMLDTMLCDGMLLNKPGGTSSGDAT  5175

Query  689   TAYANSVFNILQATTANVSALMG--ANGNTIVDEEVKDMQFELYVNVYRKSQPDPKFVDR  746
             TA++N+ +N +         ++   + GN ++     +        V+     D +F   
Sbjct  5176  TAHSNTFYNYMVHYVVAFKTILSDLSEGNKVMRIAAHNAYTTGDYQVFNTLLED-QFQTN  5234

Query  747   YYAFLNKHFSMMILSDDGVVCYNSDYATKGYIASIQNFKETLYYQNNVFMSEAKCWVETD  806
             Y  FLN       LSDD  + ++   A K  I + +NF   L    +  + + K W    
Sbjct  5235  Y--FLN------FLSDDSFI-FSKPEALK--IFTCENFSNKLQTILHTKVDQTKSW---S  5280

Query  807   LKKGPHEFCSQHTLFIKDGDDGYFLPYPDPSRILSAGCFVDDIVKTDGTLMVERFVSLAI  866
              K    EFCS H   IK   + +FL  P   R+L++   +D +   D   M  RFV++  
Sbjct  5281  TKGHIEEFCSAH--IIKTDGEYHFL--PSRGRLLASLLILDKLSDVDIYYM--RFVAILC  5334

Query  867   DAYPLTKHDDPEYQNVFWVYLQYIEKLYKDLTGHMLDSYSVMLCGDNSAKFWEESFYRDL  926
             ++   +++    +  +F V+L  +++  KD             C     +  E  FY +L
Sbjct  5335  ESAVYSRYQPEFFNGLFQVFLDKVQQFRKDYC-----------CDPCPPQLLEREFYENL  5383