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PDB ID or protein name

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  2ZW3 » Connexin 26 gap junction channel (beta-2 protein)

2zw3 » Connexin 26 gap junction channel (beta-2 protein)
<images/proteins/2zw3.gif>
Magnify 2zw3 » Connexin 26 gap junction channel (beta-2 protein)Enlarged
view of image <images/proteins/2zw3.gif>
3D view in Chime <chime.php?pdbid=2zw3>, Jmol
<http://firstglance.jmol.org/fg.htm?mol=http://opm.phar.umich.edu/pdb/2zw3.pdb>
or Webmol <webmol.php?pdbid=2zw3>

gray dot

Download Coordinates <pdb/2zw3.pdb>

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/Topology in Eukaryotic plasma membrane/
Topology	*extracellular side*
*cytoplasmic side*

    * /Type:/ 1. Transmembrane <classes.php?type=1> (2 classes)
    * /Class:/ 1.1. Alpha-helical transmembrane
      <superfamilies.php?class=1> (57 superfamilies)
    * /Superfamily:/ 1.1.52. Gap junction-forming connexin
      <families.php?superfamily=215> (1 family) 1.A.24 (TCDB)
      <http://www.tcdb.org/tcdb/index.php?tc=1.A.24>
    * /Family:/ 1.1.52.01. Connexin <families.php?family=302> (1
      protein) 1.A.24 (TCDB) <http://www.tcdb.org/tcdb/index.php?tc=1.A.24>
    * /Species:/ /Spodoptera frugiperda <species.php?species=Spodoptera
      frugiperda>/ (1 protein)
    * /Localization:/ Eukaryotic plasma membrane
      <localization.php?localization=Eukaryotic plasma membrane> (199
      proteins)

2zw3 » Connexin 26 gap junction channel (beta-2 protein)
*Hydrophobic Thickness* 	32.5 ± 1.3 Å
*Tilt Angle* 	0 ± 1°
*ΔG_transfer * 	-170.5 kcal/mol
*Links to 2zw3* 	PDB Sum
<http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=2zw3>,
SCOP <http://scop.mrc-lmb.cam.ac.uk/scop/pdb.cgi?disp=scop&id=2zw3>, MSD
<http://www.ebi.ac.uk/msd-srv/msdlite/atlas/summary/2zw3.html>, OCA
<http://bip.weizmann.ac.il/oca-bin/ocashort?id=2zw3>, MMDB
<http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=2zw3>, Dali
<http://ekhidna.biocenter.helsinki.fi/dali/daliquery?find=2zw3>
*Topology* 	subunit A (N-terminus cytoplasmic)
*Resolution* 	3.50 Å
*Related PDB Sum entries* 	1txh
<http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1txh&sourceid=OPM>,
1xir
<http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1xir&sourceid=OPM>

*Number of TM Secondary Structures* 	24

6 transmembrane subunits
*A* - Tilt: 20° - Segments: 1( 22- 45), 2( 73- 91), 3( 137- 157), 4(
187- 211)
*B* - Tilt: 19° - Segments: 1( 22- 45), 2( 73- 91), 3( 137- 157), 4(
187- 211)
*C* - Tilt: 19° - Segments: 1( 22- 45), 2( 73- 91), 3( 137- 157), 4(
187- 211)
*D* - Tilt: 19° - Segments: 1( 22- 45), 2( 73- 91), 3( 137- 157), 4(
187- 211)
*E* - Tilt: 19° - Segments: 1( 22- 45), 2( 73- 91), 3( 137- 157), 4(
187- 211)
*F* - Tilt: 19° - Segments: 1( 22- 45), 2( 73- 91), 3( 137- 157), 4(
187- 211)


Copyright © 2005- Andrei Lomize <mailto:almz@umich.edu>, Mikhail Lomize
<mailto:mlomize@umich.edu> and Irina Pogozheva <mailto:irinap@umich.edu>
University of Michigan, Ann Arbor, MI 48109 USA
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