RID: AR9023GK114 Job Title:P03300:RecName: Full=Genome polyprotein; Contains:... Program: BLASTP Subject:RecName: Full=Genome polyprotein; Contains: RecName: Full=Leader protease; Short=Lpro; Contains: RecName: Full=Protein VP0; AltName: Full=VP4-VP2; Contains: RecName: Full=Protein VP4; AltName: Full=P1A; AltName: Full=Virion protein 4; Contains: RecName: Full=Protein VP2; AltName: Full=P1B; AltName: Full=Virion protein 2; Contains: RecName: Full=Protein VP3; AltName: Full=P1C; AltName: Full=Virion protein 3; Contains: RecName: Full=Protein VP1; AltName: Full=P1D; AltName: Full=Virion protein 1; Contains: RecName: Full=Protein 2A; Short=P2A; AltName: Full=P52; Contains: RecName: Full=Protein 2B; Short=P2B; Contains: RecName: Full=Protein 2C; Short=P2C; Contains: RecName: Full=Protein 3A; Short=P3A; Contains: RecName: Full=Protein 3B-1; Short=P3B-1; AltName: Full=Genome-linked protein VPg1; Contains: RecName: Full=Protein 3B-2; Short=P3B-2; AltName: Full=Genome-linked protein VPg2; Contains: RecName: Full=Protein 3B-3; Short=P3B-3; AltName: Full=Genome-linked protein VPg3; Contains: RecName: Full=Protease 3C; AltName: Full=Picornain 3C; Short=P3C; AltName: Full=Protease P20B; Contains: RecName: Full=RNA-directed RNA polymerase 3D-POL; Short=P3D-POL; AltName: Full=P56A [Foot-and-mouth disease virus (strain A10-61)] ID: P03306.2(amino acid) Length: 2332 Query #1: RecName: Full=Genome polyprotein; Contains: RecName: Full=P1; Contains: RecName: Full=Capsid protein VP0; AltName: Full=VP4-VP2; Contains: RecName: Full=Capsid protein VP4; AltName: Full=P1A; AltName: Full=Virion protein 4; Contains: RecName: Full=Capsid protein VP2; AltName: Full=P1B; AltName: Full=Virion protein 2; Contains: RecName: Full=Capsid protein VP3; AltName: Full=P1C; AltName: Full=Virion protein 3; Contains: RecName: Full=Capsid protein VP1; AltName: Full=P1D; AltName: Full=Virion protein 1; Contains: RecName: Full=P2; Contains: RecName: Full=Protease 2A; Short=P2A; AltName: Full=Picornain 2A; AltName: Full=Protein 2A; Contains: RecName: Full=Protein 2B; Short=P2B; Contains: RecName: Full=Protein 2C; Short=P2C; Contains: RecName: Full=P3; Contains: RecName: Full=Protein 3AB; Contains: RecName: Full=Protein 3A; Short=P3A; Contains: RecName: Full=Viral protein genome-linked; Short=VPg; AltName: Full=Protein 3B; Short=P3B; Contains: RecName: Full=Protein 3CD; Contains: RecName: Full=Protease 3C; Short=P3C; Contains: RecName: Full=RNA-directed RNA polymerase; Short=RdRp; AltName: Full=3D polymerase; Short=3Dpol; AltName: Full=Protein 3D; Short=3D [Human poliovirus 1 Mahoney] Query ID: sp|P03300.3 Length: 2209 Sequences producing significant alignments: Max Total Query E Per. Description Score Score cover Value Ident Accession RecName: Full=Genome polyprotein; Contains: RecName: Full=Lead... 250 566 67% 5e-70 28.68 P03306.2 Alignments: >RecName: Full=Genome polyprotein; Contains: RecName: Full=Leader protease; Short=Lpro; Contains: RecName: Full=Protein VP0; AltName: Full=VP4-VP2; Contains: RecName: Full=Protein VP4; AltName: Full=P1A; AltName: Full=Virion protein 4; Contains: RecName: Full=Protein VP2; AltName: Full=P1B; AltName: Full=Virion protein 2; Contains: RecName: Full=Protein VP3; AltName: Full=P1C; AltName: Full=Virion protein 3; Contains: RecName: Full=Protein VP1; AltName: Full=P1D; AltName: Full=Virion protein 1; Contains: RecName: Full=Protein 2A; Short=P2A; AltName: Full=P52; Contains: RecName: Full=Protein 2B; Short=P2B; Contains: RecName: Full=Protein 2C; Short=P2C; Contains: RecName: Full=Protein 3A; Short=P3A; Contains: RecName: Full=Protein 3B-1; Short=P3B-1; AltName: Full=Genome-linked protein VPg1; Contains: RecName: Full=Protein 3B-2; Short=P3B-2; AltName: Full=Genome-linked protein VPg2; Contains: RecName: Full=Protein 3B-3; Short=P3B-3; AltName: Full=Genome-linked protein VPg3; Contains: RecName: Full=Protease 3C; AltName: Full=Picornain 3C; Short=P3C; AltName: Full=Protease P20B; Contains: RecName: Full=RNA-directed RNA polymerase 3D-POL; Short=P3D-POL; AltName: Full=P56A [Foot-and-mouth disease virus (strain A10-61)] Sequence ID: P03306.2 Length: 2332 Range 1: 1684 to 2327 Score:250 bits(638), Expect:5e-70, Method:Compositional matrix adjust., Identities:189/659(29%), Positives:322/659(48%), Gaps:59/659(8%) Query 1594 GVHDNVAILPTH--ASPGESIVIDGKEVEILDAKALEDQ---AGTNL--EITIITLKRNE 1646 GV ++P H A + I++DG+ + D + E + G ++ + +I L R Sbjct 1684 GVFGTAYLVPRHLFAEKYDKIMLDGRAMTDSDYRVFEFEIKVKGQDMLSDAALIVLHRGN 1743 Query 1647 KFRDIRPHI--PTQITETNDGVLIVNTSKYPNMYVPVGAVTEQG-YLNLGGRQTARTLMY 1703 RDI H ++ + V +VN + + A+T + + + G Y Sbjct 1744 CVRDITKHFRDTARMKKGTPVVGVVNNADVGRLIFSGEALTYKDIVVCMDGDTMPGLFAY 1803 Query 1704 NFPTRAGQCGGVITCTGK----VIGMHVGGNGSHGFAAALKRSYFTQSQGEIQWMRPSKE 1759 TRAG CGG + ++G H G G+ + + RS + + + P E Sbjct 1804 KAATRAGYCGGAVLAKDGADTFIVGTHSAGGNGVGYCSCVSRSMLQKMKAHVD-PEPHHE 1862 Query 1760 VGYPI--------INAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRLKTD--FEEAIFSK 1809 G + ++ KTKL P+ + VF PA L+ DPRL ++ IFSK Sbjct 1863 -GLIVDTRDVEERVHVMRKTKLAPTVAYGVFNPEFGPAALSNKDPRLNEGVVLDDVIFSK 1921 Query 1810 YVGN-KITEVDEYM-KEAVDHYAGQLMS-LDINTEQMCLEDAMYGTDGLEALDLSTSAGY 1866 + G+ K+TE D+ + + YA +L S L + + +A+ G DGL+A++ T+ G Sbjct 1922 HKGDAKMTEEDKALFRRCAADYASRLHSVLGTANAPLSIYEAIKGVDGLDAMEPDTAPGL 1981 Query 1867 PYVAMGKKKRDILNKQTR----DTKEMQKLLDTYGINLPLVTYVKDELRSKTKVEQGKSR 1922 P+ GK++ +++ + + + KL++ T++KDE+R KV GK+R Sbjct 1982 PWALQGKRRGALIDFENGTVGPEVEAALKLMEKREYKFACQTFLKDEIRPMEKVRAGKTR 2041 Query 1923 LIEASSLNDSVAMRMAFGNLYAAFHKNPGVITGSAVGCDPDLFWSKIPVLMEE--KLFAF 1980 +++ + + +M G A H N G GSAVGC+PD+ W + + ++ Sbjct 2042 IVDVLPVEHILYTKMMIGRFCAQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDV 2101 Query 1981 DYTGYDASLSPAWFEALKMVLEKI-----GFGDRVDYI-DYLNHSHHLYKNKTYCVKGGM 2034 DY+ +DA+ +A+ ++ E++ GF ++I L ++ H Y+NK V+GGM Sbjct 2102 DYSAFDANHCS---DAMNIMFEEVFRTDFGFHPNAEWILKTLVNTEHAYENKRITVEGGM 2158 Query 2035 PSGCSGTSIFNSMINNLIIRTLLLKTYKGIDLDHLKMIAYGDDVIASYPHEVDASLLAQS 2094 PSGCS TSI N+++NN+ + L + Y+G++LD MI+YGDD++ + +++D L Sbjct 2159 PSGCSATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDFEALKPH 2218 Query 2095 GKDYGLTMTPADKS----ATFETVTWENVTFLKRFFRADEKYPFLIHPVMPMKEIHESIR 2150 K G T+TPADKS +++T +VTFLKR F D F PVM K + + Sbjct 2219 FKSLGQTITPADKSDKGFVLGQSIT--DVTFLKRHFHMDYGTGFY-KPVMASKTLEAILS 2275 Query 2151 WTKDPRNT-QDHVRSLCLLAWHNGEEEYNKFLAKIRSVPIGRALLLPEYSTLYRRWLDS 2208 + + R T Q+ + S+ LA H+G +EY + P +P Y +LY RW+++ Sbjct 2276 FAR--RGTIQEKLISVAGLAVHSGPDEYRRLFE-----PFQGLFEIPSYRSLYLRWVNA 2327 Range 2: 1121 to 1383 Score:157 bits(397), Expect:9e-42, Method:Compositional matrix adjust., Identities:106/283(37%), Positives:147/283(51%), Gaps:26/283(9%) Query 1143 KGLEWVSNKISKFIDWLKEKIIPQARDKLEFVTKLRQLEMLENQISTIHQSCPSQEHQEI 1202 K EW+ I DW+K I + + FVT + + + ++ +E +E Sbjct 1121 KNGEWLVKLILAIRDWIKAWIASEEK----FVTMTDLVPGILEKQRDLNDPGKYKEAKEW 1176 Query 1203 LFNNVRWLSIQSK--RFAPLYAVEAKRIQKLEHTINNYIQFKSKHRIEPVCLLVHGSPGT 1260 L +N R ++S A L V A SK R EPV + + G G Sbjct 1177 L-DNARQACLKSGNVHIANLCKVVAPA--------------PSKSRPEPVVVCLRGKSGQ 1221 Query 1261 GKSVATNLIARAIAER---ENTSTYSLPPDPSHFDGYKQQGVVIMDDLNQNPDGADMKLF 1317 GKS N++A+AI+ S + PPDP HFDGY QQ VV+MDDL QNPDG D K F Sbjct 1222 GKSFLANVLAQAISTHFTGRIDSVWYCPPDPDHFDGYNQQTVVVMDDLGQNPDGKDFKYF 1281 Query 1318 CQMVSTVEFIPPMASLEEKGILFTSNYVLASTN-SSRISPPTVAHSDALARRFAFDMDIQ 1376 QMVST FIPPMASLE+KG F S ++A+TN S +P T+ DAL RRF FD+D+ Sbjct 1282 AQMVSTTGFIPPMASLEDKGKPFNSKVIIATTNLYSGFTPRTMVCPDALNRRFHFDIDVS 1341 Query 1377 VMNEYSRDGKLNMAMATEMCKNCHQPANFKRCCPLVCGKAIQL 1419 + Y + KL++ A E + + A F+ C L+ G A+++ Sbjct 1342 AKDGYKINNKLDIIKALEDT-HTNPVAMFQYDCALLNGMAVEM 1383 Range 3: 298 to 718 Score:122 bits(307), Expect:3e-31, Method:Compositional matrix adjust., Identities:130/494(26%), Positives:200/494(40%), Gaps:81/494(16%) Query 80 DRVLQLTLGNSTITTQEAANSVVAYGRWPEYLRDSEANPVDQPTEPDVA-ACRFYTLDTV 138 DR+L G++T TTQ + V YG E D A P E V A RF+ Sbjct 298 DRILTTRNGHTTSTTQSSVG--VTYGYSTE--EDHVAGPNTSGLETRVVQAERFFKKFLF 353 Query 139 SWTKESR-GWWWKLPDALRDMGLFGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVP 197 WT + G+ KL G+FG + + R+G+ V V ++F+ G Sbjct 354 DWTTDKPFGYLTKLELPTDHHGVFGHLVDSYAYMRNGWDVEVSAVGNQFNGG-------- 405 Query 198 EMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPARRFCPVDYLLGNGTLLG 257 CL M ++ + EK Y L Sbjct 406 --CL-----LVAMVPEWKAFDTREK-------------------------YQLT------ 427 Query 258 NAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIP 317 +FPHQ I+ RTN A + +PY+ D KH W + ++ L+PL ++ ++P+I Sbjct 428 ---LFPHQFISPRTNMTAHITVPYLGVNRYDQYKKHKPWTLVVMVLSPLTVSNTAAPQIK 484 Query 318 ITLTIAPMCCEFNGLRNITLPRLQGL-PVMNTPGSNQYLTADNFQSPCALPEFDVTPPID 376 + IAP G LP +G+ PV G +T D + + P + Sbjct 485 VYANIAPTYVHVAG----ELPSKEGIFPVACADGYGGLVTTDPKTADPVYGKVYNPPKTN 540 Query 377 IPGEVKNMMELAE-IDTMIPFDLSATKKNTMEMYRVRLSDKPHTDDPILCLSLSPASDPR 435 PG N++++AE T + FD + Y V +D D +L + Sbjct 541 YPGRFTNLLDVAEACPTFLRFD-------DGKPYVVTRAD----DTRLLAKFDVSLAAKH 589 Query 436 LSHTMLGEILNYYTHWAGSLKFTFLFCGFMMATGKLLVSYAPPGAD-PPKKRKEAMLGTH 494 +S+T L I YYT ++G++ F+F G + + +V+Y PPG + PP +EA H Sbjct 590 MSNTYLSGIAQYYTQYSGTINLHFMFTGSTDSKARYMVAYIPPGVETPPDTPEEAAHCIH 649 Query 495 VIWDIGLQSSCTMVVPWISNTTYRQTIDDSFTE---GGYISVFYQTRIVVPLSTPREMDI 551 WD GL S T +P++S Y T D+ G++ V+ T T + Sbjct 650 AEWDTGLNSKFTFSIPYVSAADYAYTASDTAETTNVQGWVCVYQITHGKAENDT-----L 704 Query 552 LGFVSACNDFSVRL 565 L SA DF +RL Sbjct 705 LVSASAGKDFELRL 718 Range 4: 811 to 917 Score:36.2 bits(82), Expect:7e-05, Method:Compositional matrix adjust., Identities:30/128(23%), Positives:52/128(40%), Gaps:28/128(21%) Query 736 IMYVPPGAPVPEKWDDYTWQTSSNPSIFYTYGTAP-ARISVPYVGISNAYSHFYDGFSKV 794 + +VP GAP + +SNP+ Y AP R+++PY + YDG +K Sbjct 811 LTWVPNGAP------EAALSNTSNPT---AYNKAPFTRLALPYTAPHRVLATVYDGTNKY 861 Query 795 PLKDQSAALGDSLYGAASLNDFGILAVRVVN------DHNPTKVTSKIRVYLKPKHIRVW 848 D + D G +A RV ++ + + + ++ K ++ Sbjct 862 SASDSRSG------------DLGSIAARVATQLPASFNYGAIQAQAIHELLVRMKRAELY 909 Query 849 CPRPPRAV 856 CPRP A+ Sbjct 910 CPRPLLAI 917