Acholeplasma laidlawii strain PG-8A

Вариант запроса на PubMed: Acholeplasma laidlawii PG-8A 2000:2011[dp]. Результат: 2 статьи. Можно искать сразу: Acholeplasma laidlawii PG-8A & "complete genome"[ti] 2000:2011[dp].

Итак, статья: Complete genome and proteome of Acholeplasma laidlawii.

Авторы: Lazarev VN, Levitskii SA, Basovskii YI, Chukin MM, Akopian TA, Vereshchagin VV, Kostrjukova ES, Kovaleva GY, Kazanov MD, Malko DB, Vitreschak AG, Sernova NV, Gelfand MS, Demina IA, Serebryakova MV, Galyamina MA, Vtyurin NN, Rogov SI, Alexeev DG, Ladygina VG, Govorun VM.

Abstract (полная статья недоступна, поэтому привожу это).

We present the complete genome sequence and proteogenomic map for Acholeplasma laidlawii PG-8A (class Mollicutes, order Acholeplasmatales, family Acholeplasmataceae). The genome of A. laidlawii is represented by a single 1,496,992-bp circular chromosome with an average G+C content of 31 mol%. This is the longest genome among the Mollicutes with a known nucleotide sequence. It contains genes of polymerase type I, SOS response, and signal transduction systems, as well as RNA regulatory elements, riboswitches, and T boxes. This demonstrates a significant capability for the regulation of gene expression and mutagenic response to stress. Acholeplasma laidlawii and phytoplasmas are the only Mollicutes known to use the universal genetic code, in which UGA is a stop codon. Within the Mollicutes group, only the sterol-nonrequiring Acholeplasma has the capacity to synthesize saturated fatty acids de novo. Proteomic data were used in the primary annotation of the genome, validating expression of many predicted proteins. We also detected posttranslational modifications of A. laidlawii proteins: phosphorylation and acylation. Seventy-four candidate phosphorylated proteins were found: 16 candidates are proteins unique to A. laidlawii, and 11 of them are surface-anchored or integral membrane proteins, which implies the presence of active signaling pathways. Among 20 acylated proteins, 14 contained palmitic chains, and six contained stearic chains. No residue of linoleic or oleic acid was observed. Acylated proteins were components of mainly sugar and inorganic ion transport systems and were surface-anchored proteins with unknown functions.

Идентификаторы: 21784942 (PMID: 21784942 [PubMed - in process] PMCID: PMC3165704 [Available on 2012/3/1])


Scientific classification

Kingdom: Bacteria

Division: Firmicutes

Class: Mollicutes

Order: Acholeplasmatales

Family: Acholeplasmataceae

Genus: Acholeplasma

Species: Acholeplasma laidlawii

Acholeplasma laidlawii PG-8A

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