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- GENOME
- The genome is 7277 bases in length with a G+C content of ~35%. Two structural genes are present: L1 and L2. The non structural genes are found on the opposite strand. The L1 gene encodes a protein with 506 residues and the L2 encodes a protein with 470 residues. The two non structural genes T (742 amino acid residues) and t (224 amino acid residues). The structural proteins resemble those of the pappiloma viruses while the T and t antigens resemble those of the polyoma viruses.
- EVOLUTION
- These viruses evolved via a recombination event between a papilloma virus and a polyoma virus between 10 million years ago and 50 million years ago.
- CLINICAL
- These viruses were isolated from and are thought to cause a progressively debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis syndrome. The lesions that occur in this disease are irregular thickenings and masses over the skin of the digits, body, pouch, and mucocutaneous junctions of the lips and conjunctiva. Cases have been described in both captive and wild individuals.
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