Genomic environment

Database GO

COG for FBPase

My protein: fructose 1,6-bisphosphatase - FBPase - ALX49872.1 (descroption; fasta).

COG (Clusters of Ortologous Groups of proteins) search:
Program: CDD (Conserved Domain Database)
Result:

COG ID: COG1494
E-value: 0e+00
Interval: 1-320 (protein lenght 322)
COG name: Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase or related protein
Function group: Carbohydrate transport and metabolism

Visualisation of genomic environment of FBPase

Gene Neighborhood Analysis:
Program: COGNAT (COmparative Gene Neighborhood Analysis Tool)

Search for COG: COG1494
Neighborhood Size: 9
Occurrence Threshold: 10% (OT > 15% didn't find any neighboring genes)
Taxonomy: No

Result you can see below.

Figure 1. The first group of neighboring genes.

Figure 2. The second group of neighboring genes.

Neighboring genes don't relate to fructose-1,6-bisphosphate metabolism, so I think there isn't static genomic environment. Bacteria have similar genomic environment of Fructose-1,6-bisphosphatase gene belong to Alphaproteobacteria (fig 1) or Actinobacteria (fig 2). So this architecture can be called as "linked genes", but it isn't a group of genes coding macromolecular complex.

FBPase in GO terms

The FBPase protein was quieried with AmiGO BLAST against its database to find the most similar available protein. The best finding has p-value of 1.9e-124; it is a fructose-1,6-bisphosphatase, class II (BA_5576; Uniprot: Q81JW7; Pfam: PF03320) from Bacillus anthracis str. Ames. I think GO terms can be associated with FBPase protein (see table 1).

Table 1. Go terms related to Q81JW7.

Point GO ID Term Evidence

Biological process GO:0030388 Fructose 1,6-bisphosphate metabolic process ISS

Biological process GO:0006094 Gluconeogenesis ISS

Molecular function GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity ISS

ISS means, that Inferred from Sequence or structural Similarity i.e. from manual analysis of genome annotation or from structural similarity with experimentally characterized gene products.

Term 4

← Pr10 Pr 12 →